{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:16:49Z","timestamp":1789395409763,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Cherry Marketing Institute"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s00394-018-1848-1","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T06:24:05Z","timestamp":1540880645000},"page":"3035-3046","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Montmorency tart cherry protects against age-related bone loss in female C57BL\/6 mice and demonstrates some anabolic effects"],"prefix":"10.1007","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7296-8534","authenticated-orcid":false,"given":"Brenda J.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica K.","family":"Crockett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pitipa","family":"Chongwatpol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Graef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rendina-Ruedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edralin A.","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"1848_CR1","first-page":"646","volume":"81","author":"AD Woolf","year":"2003","unstructured":"Woolf AD, Pfleger B (2003) Burden of major musculoskeletal conditions. Bull World Health Organ 81:646\u2013656","journal-title":"Bull World Health Organ"},{"key":"1848_CR2","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.ecl.2005.07.009","volume":"34","author":"S Khosla","year":"2005","unstructured":"Khosla S, Riggs BL (2005) Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am 34:1015\u20131030","journal-title":"Endocrinol Metab Clin North Am"},{"key":"1848_CR3","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","volume":"17","author":"O Johnell","year":"2006","unstructured":"Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726\u20131733","journal-title":"Osteoporos Int"},{"key":"1848_CR4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-4933-2-14","volume":"2","author":"L Ginaldi","year":"2005","unstructured":"Ginaldi L, Di Benedetto MC, De Martinis M (2005) Osteoporosis, inflammation and ageing. Immun Ageing 2:14","journal-title":"Immun Ageing"},{"key":"1848_CR5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/er.2009-0024","volume":"31","author":"SC Manolagas","year":"2010","unstructured":"Manolagas SC (2010) From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 31:266\u2013300","journal-title":"Endocr Rev"},{"key":"1848_CR6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/jbmr.262","volume":"26","author":"S Khosla","year":"2011","unstructured":"Khosla S, Melton LJ, Riggs III BL (2011) The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed? J Bone Miner Res 26:441\u2013451","journal-title":"J Bone Miner Res"},{"key":"1848_CR7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1210\/edrv.23.3.0465","volume":"23","author":"BL Riggs","year":"2002","unstructured":"Riggs BL, Khosla S, Melton LJ III (2002) Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23:279\u2013302","journal-title":"Endocr Rev"},{"key":"1848_CR8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00774-015-0656-4","volume":"33","author":"DA Callaway","year":"2015","unstructured":"Callaway DA, Jiang JX (2015) Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases. J Bone Miner Metab 33:359\u2013370","journal-title":"J Bone Miner Metab"},{"key":"1848_CR9","doi-asserted-by":"crossref","first-page":"27285","DOI":"10.1074\/jbc.M702810200","volume":"282","author":"M Almeida","year":"2007","unstructured":"Almeida M, Han L, Martin-Millan M, Plotkin LI, Stewart SA, Roberson PK, Kousteni S, O\u2019Brien CA, Bellido T, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC (2007) Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem 282:27285\u201327297","journal-title":"J Biol Chem"},{"key":"1848_CR10","doi-asserted-by":"crossref","first-page":"15087","DOI":"10.1073\/pnas.0703610104","volume":"104","author":"F Grassi","year":"2007","unstructured":"Grassi F, Tell G, Robbie-Ryan M, Gao Y, Terauchi M, Yang X, Romanello M, Jones DP, Weitzmann MN, Pacifici R (2007) Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation. Proc Natl Acad Sci USA 104:15087\u201315092","journal-title":"Proc Natl Acad Sci USA"},{"key":"1848_CR11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bone.2013.10.005","volume":"58","author":"BJ Smith","year":"2014","unstructured":"Smith BJ, Bu SY, Wang Y, Rendina E, Lim YF, Marlow D, Clarke SL, Cullen DM, Lucas EA (2014) A comparative study of the bone metabolic response to dried plum supplementation and PTH treatment in adult, osteopenic ovariectomized rat. Bone 58:151\u2013159","journal-title":"Bone"},{"key":"1848_CR12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00223-011-9477-1","volume":"88","author":"CL Shen","year":"2011","unstructured":"Shen CL, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK (2011) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats. Calcif Tissue Int 88:455\u2013463","journal-title":"Calcif Tissue Int"},{"key":"1848_CR13","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1017\/S000711451100119X","volume":"106","author":"S Hooshmand","year":"2011","unstructured":"Hooshmand S, Chai SC, Saadat RL, Payton ME, Brummel-Smith K, Arjmandi BH (2011) Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br J Nutr 106:923\u2013930","journal-title":"Br J Nutr"},{"key":"1848_CR14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jsfa.4579","volume":"92","author":"SS Chiang","year":"2012","unstructured":"Chiang SS, Liao JW, Pan TM (2012) Effect of bioactive compounds in lactobacilli-fermented soy skim milk on femoral bone microstructure of aging mice. J Sci Food Agric 92:328\u2013335","journal-title":"J Sci Food Agric"},{"key":"1848_CR15","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.3945\/jn.110.124198","volume":"140","author":"BP Halloran","year":"2010","unstructured":"Halloran BP, Wronski TJ, VonHerzen DC, Chu V, Xia X, Pingel JE, Williams AA, Smith BJ (2010) Dietary dried plum increases bone mass in adult and aged male mice. J Nutr 140:1781\u20131787","journal-title":"J Nutr"},{"key":"1848_CR16","doi-asserted-by":"crossref","first-page":"e24486","DOI":"10.1371\/journal.pone.0024486","volume":"6","author":"J Zhang","year":"2011","unstructured":"Zhang J, Lazarenko OP, Blackburn ML, Shankar K, Badger TM, Ronis MJ, Chen JR (2011) Feeding blueberry diets in early life prevent senescence of osteoblasts and bone loss in ovariectomized adult female rats. PLOS One 6:e24486","journal-title":"PLOS One"},{"key":"1848_CR17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/ajcn\/77.2.449","volume":"77","author":"M Tahiri","year":"2003","unstructured":"Tahiri M, Tressol JC, Arnaud J, Bornet FR, Bouteloup-Demange C, Feillet-Coudray C, Brandolini M, Ducros V, Pepin D, Brouns F, Roussel AM, Rayssiguier Y, Coudray C (2003) Effect of short-chain fructooligosaccharides on intestinal calcium absorption and calcium status in postmenopausal women: a stable-isotope study. Am J Clin Nutr 77:449\u2013457","journal-title":"Am J Clin Nutr"},{"key":"1848_CR18","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1021\/jf2009777","volume":"59","author":"CM Weaver","year":"2011","unstructured":"Weaver CM, Martin BR, Nakatsu CH, Armstrong AP, Clavijo A, McCabe LD, McCabe GP, Duignan S, Schoterman MH, van den Heuvel EG (2011) Galactooligosaccharides improve mineral absorption and bone properties in growing rats through gut fermentation. J Agric Food Chem 59:6501\u20136510","journal-title":"J Agric Food Chem"},{"key":"1848_CR19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/jn\/134.2.399","volume":"134","author":"TA Zafar","year":"2004","unstructured":"Zafar TA, Weaver CM, Zhao Y, Martin BR, Wastney ME (2004) Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats. J Nutr 134:399\u2013402","journal-title":"J Nutr"},{"key":"1848_CR20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jnutbio.2007.11.012","volume":"20","author":"SY Bu","year":"2009","unstructured":"Bu SY, Hunt TS, Smith BJ (2009) Dried plum polyphenols attenuate the detrimental effects of TNF-alpha on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I. J Nutr Biochem 20:35\u201344","journal-title":"J Nutr Biochem"},{"key":"1848_CR21","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00223-008-9139-0","volume":"82","author":"SY Bu","year":"2008","unstructured":"Bu SY, Lerner M, Stoecker BJ, Boldrin E, Brackett DJ, Lucas EA, Smith BJ (2008) Dried plum polyphenols inhibit osteoclastogenesis by downregulating NFATc1 and inflammatory mediators. Calcif Tissue Int 82:475\u2013488","journal-title":"Calcif Tissue Int"},{"key":"1848_CR22","doi-asserted-by":"crossref","first-page":"e70438","DOI":"10.1371\/journal.pone.0070438","volume":"8","author":"J Zhang","year":"2013","unstructured":"Zhang J, Lazarenko OP, Kang J, Blackburn ML, Ronis MJ, Badger TM, Chen JR (2013) Feeding blueberry diets to young rats dose-dependently inhibits bone resorption through suppression of RANKL in stromal cells. Plos One 8:e70438","journal-title":"Plos One"},{"key":"1848_CR23","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.bone.2006.05.024","volume":"39","author":"M Franklin","year":"2006","unstructured":"Franklin M, Bu SY, Lerner MR, Lancaster EA, Bellmer D, Marlow D, Lightfoot SA, Arjmandi BH, Brackett DJ, Lucas EA, Smith BJ (2006) Dried plum prevents bone loss in a male osteoporosis model via IGF-I and the RANK pathway. Bone 39:1331\u20131342","journal-title":"Bone"},{"key":"1848_CR24","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.bbrc.2010.09.053","volume":"401","author":"X He","year":"2010","unstructured":"He X, Andersson G, Lindgren U, Li Y (2010) Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production. Biochem Biophys Res Commun 401:356\u2013362","journal-title":"Biochem Biophys Res Commun"},{"key":"1848_CR25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jnutbio.2017.09.014","volume":"55","author":"JL Graef","year":"2017","unstructured":"Graef JL, Rendina-Ruedy E, Crockett EK, Ouyang P, King JB, Cichewicz RH, Lucas EA, Smith BJ (2017) Select phenolic fractions from dried plum enhance osteoblast activity through BMP-2 signaling. J Nutr Biochem 55:59\u201367","journal-title":"J Nutr Biochem"},{"key":"1848_CR26","unstructured":"USDA Nation (2014) Nutrient database for standard reference, release 27"},{"key":"1848_CR27","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1080\/10942912.2012.680221","volume":"17","author":"R Jovanovic-Malinovska","year":"2014","unstructured":"Jovanovic-Malinovska R, Kuzmanova S, Winkelhausen E (2014) Oligosaccharide profile in furits and vegetables as sources of prebiotics and functional foods. Int J Food Prop 17:949\u2013965","journal-title":"Int J Food Prop"},{"key":"1848_CR28","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3390\/nu6020829","volume":"6","author":"PG Bell","year":"2014","unstructured":"Bell PG, Walshe IH, Davison GW, Stevenson E, Howatson G (2014) Montmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cycling. Nutrients 6:829\u2013843","journal-title":"Nutrients"},{"key":"1848_CR29","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1089\/jmf.2008.0270","volume":"12","author":"EM Seymour","year":"2009","unstructured":"Seymour EM, Lewis SK, Urcuyo-Llanes DE, Tanone II, Kirakosyan A, Kaufman PB, Bolling SF (2009) Regular tart cherry intake alters abdominal adiposity, adipose gene transcription, and inflammation in obesity-prone rats fed a high fat diet. J Med Food 12:935\u2013942","journal-title":"J Med Food"},{"key":"1848_CR30","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1021\/jf8032039","volume":"57","author":"V Mulabagal","year":"2009","unstructured":"Mulabagal V, Lang GA, DeWitt DL, Dalavoy SS, Nair MG (2009) Anthocyanin content, lipid peroxidation and cyclooxygenase enzyme inhibitory activities of sweet and sour cherries. J Agric Food Chem 57:1239\u20131246","journal-title":"J Agric Food Chem"},{"key":"1848_CR31","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.1021\/jf0107508","volume":"49","author":"NP Seeram","year":"2001","unstructured":"Seeram NP, Bourquin LD, Nair MG (2001) Degradation products of cyanidin glycosides from tart cherries and their bioactivities. J Agric Food Chem 49:4924\u20134929","journal-title":"J Agric Food Chem"},{"key":"1848_CR32","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1089\/jmf.2007.658","volume":"11","author":"EM Seymour","year":"2008","unstructured":"Seymour EM, Singer AA, Kirakosyan A, Urcuyo-Llanes DE, Kaufman PB, Bolling SF (2008) Altered hyperlipidemia, hepatic steatosis, and hepatic peroxisome proliferator-activated receptors in rats with intake of tart cherry. J Med Food 11:252\u2013259","journal-title":"J Med Food"},{"key":"1848_CR33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3940(02)00583-9","volume":"194","author":"SY Kang","year":"2003","unstructured":"Kang SY, Seeram NP, Nair MG, Bourquin LD (2003) Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. Cancer Lett 194:13\u201319","journal-title":"Cancer Lett"},{"key":"1848_CR34","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1359\/jbmr.070507","volume":"22","author":"V Glatt","year":"2007","unstructured":"Glatt V, Canalis E, Stadmeyer L, Bouxsein ML (2007) Age-related changes in trabecular architecture differ in female and male C57BL\/6J mice. J Bone Miner Res 22:1197\u20131207","journal-title":"J Bone Miner Res"},{"key":"1848_CR35","doi-asserted-by":"crossref","first-page":"e60569","DOI":"10.1371\/journal.pone.0060569","volume":"8","author":"E Rendina","year":"2013","unstructured":"Rendina E, Hembree KD, Davis MR, Marlow D, Clarke SL, Halloran BP, Lucas EA, Smith BJ (2013) Dried plum\u2019s unique capacity to reverse bone loss and alter bone metabolism in postmenopausal osteoporosis model. Plos One 8:e60569","journal-title":"Plos One"},{"key":"1848_CR36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jnutbio.2010.10.010","volume":"23","author":"E Rendina","year":"2012","unstructured":"Rendina E, Lim YF, Marlow D, Wang Y, Clarke SL, Kuvibidila S, Lucas EA, Smith BJ (2012) Dietary supplementation with dried plum prevents ovariectomy-induced bone Loss in C57BL\/6 mice and modulates the immune response. J Nutr Biochem 23:60\u201368","journal-title":"J Nutr Biochem"},{"key":"1848_CR37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2003.12.073","volume":"314","author":"XC Bai","year":"2004","unstructured":"Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ (2004) Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun 314:197\u2013207","journal-title":"Biochem Biophys Res Commun"},{"key":"1848_CR38","doi-asserted-by":"crossref","first-page":"27438","DOI":"10.1074\/jbc.M109.023572","volume":"284","author":"M Almeida","year":"2009","unstructured":"Almeida M, Ambrogini E, Han L, Manolagas SC, Jilka RL (2009) Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem 284:27438\u201327448","journal-title":"J Biol Chem"},{"key":"1848_CR39","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1182\/blood-2004-09-3662","volume":"106","author":"NK Lee","year":"2005","unstructured":"Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY (2005) A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 106:852\u2013859","journal-title":"Blood"},{"key":"1848_CR40","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1016\/j.bbagen.2014.08.001","volume":"1840","author":"Z Zhang","year":"2014","unstructured":"Zhang Z, Zhang J, Xiao J (2014) Selenoproteins and selenium status in bone physiology and pathology. Biochim Biophys Acta 1840:3246\u20133256","journal-title":"Biochim Biophys Acta"},{"key":"1848_CR41","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1210\/en.2004-1021","volume":"146","author":"JM Lean","year":"2005","unstructured":"Lean JM, Jagger CJ, Kirstein B, Fuller K, Chambers TJ (2005) Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology 146:728\u2013735","journal-title":"Endocrinology"},{"key":"1848_CR42","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00774-013-0493-2","volume":"32","author":"KA Staines","year":"2014","unstructured":"Staines KA, Zhu D, Farquharson C, MacRae VE (2014) Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling. J Bone Miner Metab 32:240\u2013251","journal-title":"J Bone Miner Metab"},{"key":"1848_CR43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.foodchem.2014.08.114","volume":"171","author":"A Kirakosyan","year":"2015","unstructured":"Kirakosyan A, Seymour EM, Wolforth J, McNish R, Kaufman PB, Bolling SF (2015) Tissue bioavailability of anthocyanins from whole tart cherry in healthy rats. Food Chem 171:26\u201331","journal-title":"Food Chem"},{"key":"1848_CR44","doi-asserted-by":"crossref","first-page":"H105","DOI":"10.1111\/j.1750-3841.2012.02681.x","volume":"77","author":"B Ou","year":"2012","unstructured":"Ou B, Bosak KN, Brickner PR, Iezzoni DG, Seymour EM (2012) Processed tart cherry products\u2014comparative phytochemical content, in vitro antioxidant capacity and in vitro anti-inflammatory activity. J Food Sci 77:H105\u2013H112","journal-title":"J Food Sci"},{"key":"1848_CR45","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s00223-013-9819-2","volume":"94","author":"BJ Smith","year":"2014","unstructured":"Smith BJ, Graef JL, Wronski TJ, Rendina E, Williams AA, Clark KA, Clarke SL, Lucas EA, Halloran BP (2014) Effects of dried plum supplementation on bone metabolism in adult C57BL\/6 male mice. Calcif Tissue Int 94:442\u2013453","journal-title":"Calcif Tissue Int"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-018-1848-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-018-1848-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-018-1848-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T03:12:03Z","timestamp":1573269123000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-018-1848-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,30]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1848"],"URL":"https:\/\/doi.org\/10.1007\/s00394-018-1848-1","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,30]]},"assertion":[{"value":"8 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors, B. J. Smith, E.K. Crockett, P. Chongwatpol, J. L. Graef, E. Rendina-Ruedy, S. L. Clarke and E. A. Lucas, have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}