{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:42:00Z","timestamp":1789987320780,"version":"4.0.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["478550\/2009-0"],"award-info":[{"award-number":["478550\/2009-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/20268-0"],"award-info":[{"award-number":["2010\/20268-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/19321-9"],"award-info":[{"award-number":["2012\/19321-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s00394-018-1851-6","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T05:58:44Z","timestamp":1541570324000},"page":"3059-3068","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A proteomics\u2013metabolomics approach indicates changes in hypothalamic glutamate\u2013GABA metabolism of adult female rats submitted to intrauterine growth restriction"],"prefix":"10.1007","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7088-0187","authenticated-orcid":false,"given":"Amanda P.","family":"Pedroso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P. S.","family":"Dornellas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana P.","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josias F.","family":"Pagotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila M.","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia M. O.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Klawitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Christians","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre K.","family":"Tashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3071-9134","authenticated-orcid":false,"given":"Eliane Beraldi","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,7]]},"reference":[{"key":"1851_CR1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1056\/NEJM197608122950701","volume":"295","author":"GP Ravelli","year":"1976","unstructured":"Ravelli GP, Stein ZA, Susser MW (1976) Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 295:349\u2013353. \nhttps:\/\/doi.org\/10.1056\/NEJM197608122950701","journal-title":"N Engl J Med"},{"key":"1851_CR2","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1136\/bmj.303.6809.1019","volume":"303","author":"CN Hales","year":"1991","unstructured":"Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C, Winter PD (1991) Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 303:1019\u20131022","journal-title":"BMJ"},{"key":"1851_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1136\/bmj.306.6869.24","volume":"306","author":"CM Law","year":"1993","unstructured":"Law CM, de Swiet M, Osmond C, Favers PM, Barker DJ, Cruddas AM, Fall CH (1993) Initiation of hypertension in utero and its amplification throughout life. BMJ 306:24\u201327","journal-title":"BMJ"},{"key":"1851_CR4","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1161\/01.CIR.94.6.1310","volume":"94","author":"GC Curhan","year":"1996","unstructured":"Curhan GC, Chertow GM, Willet WC, Spiegelman D, Colditz GA, Manson JE, Speizer FE, Stampfer MJ (1996) Birth weight and adult hypertension and obesity in women. Circulation 94:1310\u20131315. \nhttps:\/\/doi.org\/10.1161\/01.CIR.94.6.1310","journal-title":"Circulation"},{"key":"1851_CR5","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1161\/01.CIR.94.12.3246","volume":"94","author":"GC Curhan","year":"1996","unstructured":"Curhan GC, Willet WC, Rimm EB, Spiegleman D, Ascherio AL, Stampfer MJ (1996) Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation 94:3246\u20133250. \nhttps:\/\/doi.org\/10.1161\/01.CIR.94.12.3246","journal-title":"Circulation"},{"key":"1851_CR6","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.earlhumdev.2006.07.001","volume":"82","author":"T Roseboom","year":"2006","unstructured":"Roseboom T, de Rooij S, Painter R (2006) The Dutch famine and its long term consequences for adult health. Early Hum Dev 82:485\u2013491. \nhttps:\/\/doi.org\/10.1016\/j.earlhumdev.2006.07.001","journal-title":"Early Hum Dev"},{"key":"1851_CR7","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/BF00400248","volume":"35","author":"CN Hales","year":"1992","unstructured":"Hales CN, Barker DJP (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35:595\u2013601","journal-title":"Diabetologia"},{"key":"1851_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/bmb\/60.1.5","volume":"60","author":"C Hales","year":"2001","unstructured":"Hales C, Barker D (2001) The thrifty phenotype hypothesis. Br Med Bull 60:5\u201320","journal-title":"Br Med Bull"},{"key":"1851_CR9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1152\/ajpendo.2000.279.1.E83","volume":"279","author":"M Vickers","year":"2000","unstructured":"Vickers M, Breier B, Cutfield WS, Hofman PL, Gluckman PD (2000) Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol Endocrinol Metab 279:83\u201387. \nhttps:\/\/doi.org\/10.1152\/ajpendo.2000.279.1.E83","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1851_CR10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1177\/1933719107303983","volume":"14","author":"M Desai","year":"2007","unstructured":"Desai M, Gayle D, Han G, Ross MG (2007) Programmed hyperphagia due to reduced anorexigenic mechanisms in intrauterine growth-restricted offspring. Reprod Sci 14:329\u2013337. \nhttps:\/\/doi.org\/10.1177\/1933719107303983","journal-title":"Reprod Sci"},{"key":"1851_CR11","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1093\/jn\/130.10.2582","volume":"130","author":"A Plagemann","year":"2000","unstructured":"Plagemann A, Harder T, Rake A, Melchior K, Rohde W, D\u00f6rner G (2000) Hypothalamic nuclei are malformed in weanling offspring of low protein malnourished rat dams. J Nutr 130:2582\u20132589. \nhttps:\/\/doi.org\/10.1093\/jn\/130.10.2582","journal-title":"J Nutr"},{"key":"1851_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1054\/npep.1999.0778","volume":"34","author":"A Plagemann","year":"2000","unstructured":"Plagemann A, Waas T, Harder T, Rittel F, Ziska T, Rohde W (2000) Hypothalamic neuropeptide Y levels in weanling offspring of low-protein malnourished mother rats. Neuropeptides 34:1\u20136. \nhttps:\/\/doi.org\/10.1054\/npep.1999.0778","journal-title":"Neuropeptides"},{"key":"1851_CR13","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1210\/en.2007-1263","volume":"149","author":"F Delahaye","year":"2008","unstructured":"Delahaye F, Breton C, Risold PY, Enache M, Dutriez-Casteloot I, Laborie C, Lesage J, Vieau D (2008) Maternal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups. Endocrinology 149:470\u2013475. \nhttps:\/\/doi.org\/10.1210\/en.2007-1263","journal-title":"Endocrinology"},{"key":"1851_CR14","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1093\/ajcn\/70.5.811","volume":"70","author":"ACJ Ravelli","year":"1999","unstructured":"Ravelli ACJ, van der Meulen JHP, Osmond C, Barker DJP, Blecker OP (1999) Obesity at the age of 50 y in men and women exposed to famine prenatally. Am J Clin Nutr 70:811\u2013816. \nhttps:\/\/doi.org\/10.1093\/ajcn\/70.5.811","journal-title":"Am J Clin Nutr"},{"key":"1851_CR15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1743-7075-7-69","volume":"7","author":"M Palou","year":"2010","unstructured":"Palou M, Priego T, S\u00e1nchez J, Palou A, Pic\u00f3 C (2010) Sexual dimorphism in the lasting effects of moderate caloric restriction during gestation on energy homeostasis in rats is related with fetal programming of insulin and leptin resistance. Nutr Metab 7:69\u201379. \nhttps:\/\/doi.org\/10.1186\/1743-7075-7-69","journal-title":"Nutr Metab"},{"key":"1851_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2012.00436","volume":"3","author":"C Pic\u00f3","year":"2012","unstructured":"Pic\u00f3 C, Palou M, Priego T, S\u00e1nchez J, Palou A (2012) Metabolic programming of obesity by energy restriction during the perinatal period: different outcomes depending on gender and period, type and severity of restriction. Front Physiol 3:1\u201314. \nhttps:\/\/doi.org\/10.3389\/fphys.2012.00436","journal-title":"Front Physiol"},{"key":"1851_CR17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12953-015-0088-z","volume":"13","author":"AP Souza","year":"2015","unstructured":"Souza AP, Pedroso AP, Watanabe RL, Dornellas AP, Boldarine VT, Laure HJ, Nascimento CM, Oyama LM, Rosa JC, Ribeiro EB (2015) Gender-specific effects of intrauterine growth restriction on the adipose tissue of adult rats: a proteomic approach. Proteome Sci 13:32\u201346. \nhttps:\/\/doi.org\/10.1186\/s12953-015-0088-z","journal-title":"Proteome Sci"},{"key":"1851_CR18","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.nut.2006.07.002","volume":"22","author":"FLC Sardinha","year":"2006","unstructured":"Sardinha FLC, Telles MM, Albuquerque KT, Oyama LM, Guimar\u00e3es PA, Santos OF, Ribeiro EB (2006) Gender difference in the effect of intrauterine malnutrition on the central anorexigenic action of insulin in adult rats. Nutrition 22:1152\u20131161. \nhttps:\/\/doi.org\/10.1016\/j.nut.2006.07.002","journal-title":"Nutrition"},{"key":"1851_CR19","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1021\/acs.jproteome.6b00923","volume":"16","author":"AP Pedroso","year":"2017","unstructured":"Pedroso AP, Souza AP, Dornellas APS, Oyama LM, Nascimento CM, Santos GM, Rosa JC, Bertolla RP, Klawitter J, Christians U, Tashima AK, Ribeiro EB (2017) Intrauterine growth restriction programs the hypothalamus of adult male rats: integrated analysis of proteomic and metabolomics data. J Proteome Res 16:1515\u20131525. \nhttps:\/\/doi.org\/10.1021\/acs.jproteome.6b00923","journal-title":"J Proteome Res"},{"key":"1851_CR20","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1074\/mcp.M500230-MCP200","volume":"5","author":"JC Silva","year":"2006","unstructured":"Silva JC, Gorenstein MV, Li GZ, Vissers JPC, Geromanos SJ (2006) Absolute quantification of proteins by LCMSE: a virtue of parallel MS acquisition. Mol Cell Proteom 5:144\u2013156. \nhttps:\/\/doi.org\/10.1074\/mcp.M500230-MCP200","journal-title":"Mol Cell Proteom"},{"key":"1851_CR21","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nprot.2012.024","volume":"7","author":"M Yuan","year":"2012","unstructured":"Yuan M, Breitkopf SB, Yang X, Asara JM (2012) A positive\/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue. Nat Protoc 7:872\u2013881. \nhttps:\/\/doi.org\/10.1038\/nprot.2012.024","journal-title":"Nat Protoc"},{"key":"1851_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.rmed.2016.10.011","volume":"121","author":"W Checkley","year":"2016","unstructured":"Checkley W, Deza MP, Klawitter J, Romero KM, Klawitter J, Pollard SL, Wise RA, Christians U, Hansel NN (2016) Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches. Respir Med 121:59\u201366. \nhttps:\/\/doi.org\/10.1016\/j.rmed.2016.10.011","journal-title":"Respir Med"},{"key":"1851_CR23","doi-asserted-by":"publisher","first-page":"D380","DOI":"10.1093\/nar\/gkv1277","volume":"44","author":"D Szklarczyk","year":"2016","unstructured":"Szklarczyk D, Santos A, von Mering C, Jensen LJ, Bork P, Kuhn M (2016) STITCH 5: augmenting protein\u2013chemical interaction networks with tissue and affinity data. Nucleic Acids Res 44:D380\u2013D384. \nhttps:\/\/doi.org\/10.1093\/nar\/gkv1277","journal-title":"Nucleic Acids Res"},{"key":"1851_CR24","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1093\/bioinformatics\/btr499","volume":"27","author":"A Kamburov","year":"2011","unstructured":"Kamburov A, Cavill R, Ebbels TMD, Herwig R, Keun HC (2011) Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA. Bioinformatics 27:2917\u20132918. \nhttps:\/\/doi.org\/10.1093\/bioinformatics\/btr499","journal-title":"Bioinformatics"},{"key":"1851_CR25","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1017\/S0007114508061503","volume":"101","author":"LC P\u00f4rto","year":"2009","unstructured":"P\u00f4rto LC, Sardinha FL, Telles MM, Guimar\u00e3es RB, Albuquerque KT, Andrade IS, Oyama LM, Nascimento CM, Santos OF, Ribeiro EB (2009) Impairment of the serotonergic control of feeding in adult female rats exposed to intra-uterine malnutrition. Br J Nutr 101:1255\u20131261. \nhttps:\/\/doi.org\/10.1017\/S0007114508061503","journal-title":"Br J Nutr"},{"key":"1851_CR26","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1159\/000341437","volume":"30","author":"MA Landgraf","year":"2012","unstructured":"Landgraf MA, Landgraf RG, Silva RC, Semedo P, C\u00e2mara NOS, Fortes ZB (2012) Intrauterine undernourishment alters TH1\/TH2 cytokine balance and attenuates lung allergic inflammation in Wistar rats. Cell Physiol Biochem 30:552\u2013562. \nhttps:\/\/doi.org\/10.1159\/000341437","journal-title":"Cell Physiol Biochem"},{"key":"1851_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijdevneu.2015.12.002","volume":"49","author":"A Tungalagsuvd","year":"2016","unstructured":"Tungalagsuvd A, Matsuzaki T, Iwasa T, Munkhzaya M, Yiliyasi M, Kawami T, Kato T, Kuwahara A, Irahara M (2016) The expression of orexigenic and anorexigenic factors in middle-aged female rats that had been subjected to prenatal undernutrition. Int J Dev Neurosc 49:1\u20135. \nhttps:\/\/doi.org\/10.1016\/j.ijdevneu.2015.12.002","journal-title":"Int J Dev Neurosc"},{"key":"1851_CR28","doi-asserted-by":"publisher","first-page":"E663","DOI":"10.1152\/ajpendo.00461.2004","volume":"288","author":"H Guan","year":"2005","unstructured":"Guan H, Arany E, van Beek JP, Chamson-Reig A, Thyssen S, Hill DJ, Yang K (2005) Adipose tissue gene expression profiling reveals distinct molecular pathways that define visceral adiposity in offspring of maternal protein-restricted rats. Am J Physiol Endocrinol Metab 288:E663\u2013E673. \nhttps:\/\/doi.org\/10.1152\/ajpendo.00461.2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1851_CR29","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.mce.2008.06.020","volume":"297","author":"RH Jones","year":"2009","unstructured":"Jones RH, Ozanne SE (2009) Fetal programming of glucose-insulin metabolism. Mol Cell Endocrinol 297:4\u20139. \nhttps:\/\/doi.org\/10.1016\/j.mce.2008.06.020","journal-title":"Mol Cell Endocrinol"},{"key":"1851_CR30","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1463-1326.2012.01653.x","volume":"14","author":"MS Martin-Gronert","year":"2012","unstructured":"Martin-Gronert MS, Ozanne SE (2012) Metabolic programming of insulin action and secretion. Diabetes Obes Metab 14:29\u201339. \nhttps:\/\/doi.org\/10.1111\/j.1463-1326.2012.01653.x","journal-title":"Diabetes Obes Metab"},{"key":"1851_CR31","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1210\/en.2012-1640","volume":"154","author":"M Garg","year":"2013","unstructured":"Garg M, Thamotharan M, Dai Y, Lagishetty V, Matveyenko AV, Lee WN, Devaskar SU (2013) Glucose intolerance and lipid metabolic adaptations in response to intrauterine and postnatal calorie restriction in male adult rats. Endocrinology 154:102\u2013113. \nhttps:\/\/doi.org\/10.1210\/en.2012-1640","journal-title":"Endocrinology"},{"key":"1851_CR32","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.1210\/en.2004-1520","volume":"146","author":"CT Souza de","year":"2005","unstructured":"de Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, Saad MJ, Velloso LA (2005) Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146:4192\u20134199. \nhttps:\/\/doi.org\/10.1210\/en.2004-1520","journal-title":"Endocrinology"},{"key":"1851_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jnutbio.2016.08.008","volume":"42","author":"HC Cesar","year":"2017","unstructured":"Cesar HC, Pisani LP (2017) Fatty-acid-mediated hypothalami inflammation and epigenetic programming. J Nutr Biochem 42:1\u20136. \nhttps:\/\/doi.org\/10.1016\/j.jnutbio.2016.08.008","journal-title":"J Nutr Biochem"},{"key":"1851_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijdevneu.2015.04.004","volume":"44","author":"T Iwasa","year":"2015","unstructured":"Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kuwahara A, Yasui T, Irahara M (2015) Prenatal undernutrition increases the febrile response to lipopolysaccharides in adulthood in male rats. Int J Dev Neurosc 44:1\u20135. \nhttps:\/\/doi.org\/10.1016\/j.ijdevneu.2015.04.004","journal-title":"Int J Dev Neurosc"},{"key":"1851_CR35","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/jcbfm.2012.22","volume":"32","author":"M Hage El","year":"2012","unstructured":"El Hage M, Masson J, Conjard-Duplany A, Ferrier B, Baverel G, Martin G (2012) Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomics study with carbon 13 NMR. J Cereb Blood Flow Metab 32:816\u2013824. \nhttps:\/\/doi.org\/10.1038\/jcbfm.2012.22","journal-title":"J Cereb Blood Flow Metab"},{"key":"1851_CR36","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/jnc.12812","volume":"131","author":"U Sonnewald","year":"2014","unstructured":"Sonnewald U (2014) Glutamate synthesis has to be matched by its degradation\u2014where do all the carbons go? J Neurochem 131:399\u2013406. \nhttps:\/\/doi.org\/10.1111\/jnc.12812","journal-title":"J Neurochem"},{"key":"1851_CR37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1385\/MN:22:1-3:021","volume":"22","author":"B Hassel","year":"2000","unstructured":"Hassel B (2000) Carboxylation and anaplerosis in neurons and glia. Mol Neurobiol 22:21\u201340. \nhttps:\/\/doi.org\/10.1385\/MN:22:1-3:021","journal-title":"Mol Neurobiol"},{"key":"1851_CR38","doi-asserted-by":"publisher","first-page":"2498S","DOI":"10.1093\/jn\/131.9.2498S","volume":"131","author":"KL Behar","year":"2001","unstructured":"Behar KL, Rothman DL (2001) In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyric acid cycling in rodent and human cortex: the central role of glutamine. J Nutr 131:2498S\u20132504S. \nhttps:\/\/doi.org\/10.1093\/jn\/131.9.2498S","journal-title":"J Nutr"},{"key":"1851_CR39","doi-asserted-by":"publisher","first-page":"929","DOI":"10.2174\/156802606777323719","volume":"6","author":"A Schousboe","year":"2006","unstructured":"Schousboe A, Waagepetersen HS (2006) Glial modulation of GABAergic and glutamatergic neurotransmission. Curr Top Med Chem 6:929\u2013934. \nhttps:\/\/doi.org\/10.2174\/156802606777323719","journal-title":"Curr Top Med Chem"},{"key":"1851_CR40","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1159\/000112551","volume":"1","author":"AJ Patel","year":"1978","unstructured":"Patel AJ, del Vecchio M, Atkinson DJ (1978) Effect of undernutrition on the regional development of transmitter enzymes: glutamate decarboxylase and choline acetyltransferase. Dev Neurosc 1:41\u201353. \nhttps:\/\/doi.org\/10.1159\/000112551","journal-title":"Dev Neurosc"},{"key":"1851_CR41","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/BF01000530","volume":"8","author":"C Chanez","year":"1993","unstructured":"Chanez C, Rabin O, Heroux M, Giguere JF (1993) Cerebral amino acid changes in an animal model of intrauterine growth retardation. Metab Brain Dis 8:61\u201372","journal-title":"Metab Brain Dis"},{"key":"1851_CR42","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/pmic.201200376","volume":"12","author":"PC Guest","year":"2012","unstructured":"Guest PC, Urday S, Ma D, Stelzhammer V, Harris LW, Amess B, Pietsch S, Ohein C, Ozanne SE, Bahn S (2012) Proteomic analysis of the maternal protein restriction rat model for schizophrenia: identification of translational changes in hormonal signaling pathways and glutamate neurotransmission. Proteomics 12:358\u20133589. \nhttps:\/\/doi.org\/10.1002\/pmic.201200376","journal-title":"Proteomics"},{"key":"1851_CR43","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1038\/jcbfm.2010.61","volume":"30","author":"RM Sickmann","year":"2010","unstructured":"Sickmann RM, Waagepetersen HS, Schousboe A, Benie AJ, Bouman SD (2010) Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. J Cereb Blood Flow Metab 30:1527\u20131537. \nhttps:\/\/doi.org\/10.1038\/jcbfm.2010.61","journal-title":"J Cereb Blood Flow Metab"},{"key":"1851_CR44","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.physbeh.2011.04.046","volume":"104","author":"BG Stanley","year":"2011","unstructured":"Stanley BG, Urstadt KR, Charles JR, Kee T (2011) Glutamate and GABA in lateral hypothalamic mechanisms controlling food intake. Physiol Behav 104:40\u201346. \nhttps:\/\/doi.org\/10.1016\/j.physbeh.2011.04.046","journal-title":"Physiol Behav"},{"key":"1851_CR45","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.neuropharm.2013.10.033","volume":"79","author":"JR Charles","year":"2014","unstructured":"Charles JR, Duva MA, Ramirez GJ, Lara RL, Yang CR, Stanley BG (2014) Activation of lateral hypothalamic mGlu1 and mGlu5 receptors elicits feeding in rats. Neuropharmacology 79:59\u201365. \nhttps:\/\/doi.org\/10.1016\/j.neuropharm.2013.10.033","journal-title":"Neuropharmacology"},{"key":"1851_CR46","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.cmet.2007.04.001","volume":"5","author":"Q Tong","year":"2007","unstructured":"Tong Q, Ye C, McCrimmon RJ, Dhilon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB (2007) Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5:383\u2013393. \nhttps:\/\/doi.org\/10.1016\/j.cmet.2007.04.001","journal-title":"Cell Metab"},{"key":"1851_CR47","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.neuroscience.2015.09.044","volume":"310","author":"DE Rivera-Aponte","year":"2015","unstructured":"Rivera-Aponte DE, M\u00e9ndez-Gonz\u00e1les MP, Rivera-Pag\u00e1n AF, Kucheryavykh YV, Kucheryavykh LY, Skatchkov SN, Eaton MJ (2015) Hyperglycemia reduces functional expression of astrocytic Kir4.1 channels and glial glutamate uptake. Neuroscience 310:216\u2013223. \nhttps:\/\/doi.org\/10.1016\/j.neuroscience.2015.09.044","journal-title":"Neuroscience"},{"key":"1851_CR48","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13041-016-0223-5","volume":"9","author":"Y Zheng","year":"2016","unstructured":"Zheng Y, Yang Y, Dong B, Zheng H, Lin X, Du Y, Li X, Zhao L, Gao H (2016) Metabonomic profiles delineate potential role of glutamate-glutamine cycle in db\/db mice with diabetes-associated cognitive decline. Mol Brain 9:40\u201348. \nhttps:\/\/doi.org\/10.1186\/s13041-016-0223-5","journal-title":"Mol Brain"},{"key":"1851_CR49","doi-asserted-by":"publisher","first-page":"7604","DOI":"10.1523\/JNEUROSCI.5328-03.2004","volume":"24","author":"A Kalsbeek","year":"2004","unstructured":"Kalsbeek A, La Fleus S, Van Heijningen C, Buijs RM (2004) Suprachiasmatic GABAergic inputs to the paraventricular nucleus control plasma glucose concentrations in the rat via sympathetic innervation of the liver. J Neurosci 24:7604\u20137613. \nhttps:\/\/doi.org\/10.1523\/JNEUROSCI.5328-03.2004","journal-title":"J Neurosci"},{"key":"1851_CR50","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.cell.2012.09.020","volume":"151","author":"D Kong","year":"2012","unstructured":"Kong D, Tong Q, Ye C, Koda S, Fuller PM, Krashes MJ, Vong L, Ray RS, Olson DP, Lowell BB (2012) GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell 151:645\u2013657. \nhttps:\/\/doi.org\/10.1016\/j.cell.2012.09.020","journal-title":"Cell"},{"key":"1851_CR51","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1111\/ejn.13076","volume":"42","author":"MS Dicken","year":"2015","unstructured":"Dicken MS, Hughes AR, Hentges ST (2015) Gad1 mRNA as a reliable indicator of altered GABA release from orexigenic neurons in the hypothalamus. Eur J Neurosci 42:2644\u20132653. \nhttps:\/\/doi.org\/10.1111\/ejn.13076","journal-title":"Eur J Neurosci"},{"key":"1851_CR52","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.cmet.2005.05.005","volume":"1","author":"S Yura","year":"2005","unstructured":"Yura S, Itoh H, Sagawa N, Yamamoto H, Masuzaki H, Nakao K, Kawamura M, Takemura M, Kakui K, Ogawa Y, Fujii S (2005) Role of premature leptin surge in obesity resulting from intrauterine undernutrition. Cell Metab 1:371\u2013378. \nhttps:\/\/doi.org\/10.1016\/j.cmet.2005.05.005","journal-title":"Cell Metab"},{"key":"1851_CR53","doi-asserted-by":"publisher","first-page":"e30616","DOI":"10.1371\/journal.pone.0030616","volume":"7","author":"B Coup\u00e9","year":"2012","unstructured":"Coup\u00e9 B, Grit J, Hulin P, Randuineau G, Parnet P (2012) Postnatal growth after intrauterine growth restriction alters central leptin signal and energy homeostasis. PLoS One 7:e30616. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0030616","journal-title":"PLoS One"},{"key":"1851_CR54","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1210\/en.2014-1412","volume":"155","author":"MC Evans","year":"2014","unstructured":"Evans MC, Rizwan MZ, Anderson GM (2014) Insulin action on GABA neurons is a critical regulator of energy balance but not fertility in mice. Endocrinology 155:4368\u20134379. \nhttps:\/\/doi.org\/10.1210\/en.2014-1412","journal-title":"Endocrinology"},{"key":"1851_CR55","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neuron.2011.05.028","volume":"71","author":"L Vong","year":"2011","unstructured":"Vong L, Ye C, Yang Z, Choi B, Chua SJ, Lowell BB (2011) Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71:142\u2013154. \nhttps:\/\/doi.org\/10.1016\/j.neuron.2011.05.028","journal-title":"Neuron"},{"key":"1851_CR56","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.1172\/JCI64102","volume":"122","author":"E Fuente-Mart\u00edn","year":"2012","unstructured":"Fuente-Mart\u00edn E, Garc\u00eda-C\u00e1ceres C, Granado M, de Ceballos ML, S\u00e1nchez-Garrido M, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Ariz\u00f3n P, D\u00edaz F, Argente J, Horvath TL, Chowen J (2012) Leptin regulates glutamate and glucose transporters in hypothalami astrocytes. J Clin Investig 122:3900\u20133913. \nhttps:\/\/doi.org\/10.1172\/JCI64102","journal-title":"J Clin Investig"},{"key":"1851_CR57","doi-asserted-by":"publisher","first-page":"e1001506","DOI":"10.1371\/journal.pbio.1001506","volume":"11","author":"V Nordstr\u00f6m","year":"2013","unstructured":"Nordstr\u00f6m V, Willersh\u00e4user M, Herzer S, Rozman J, von B und Halbach, Meldner O, Rothermel S, Kaden U, Roth S, Waldeck FC, Gretz C, de Angelis N, Draguhn MH, Klingenspor A, Gr\u00f6ne M, Jannemann HJ R (2013) Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. PLoS Biol 11:e1001506. \nhttps:\/\/doi.org\/10.1371\/journal.pbio.1001506","journal-title":"PLoS Biol"},{"key":"1851_CR58","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ijdevneu.2017.01.005","volume":"57","author":"D Garc\u00eda-Contreras","year":"2017","unstructured":"Garc\u00eda-Contreras D, Valent D, V\u00e1zquez-G\u00f3mez M, Arroyo L, Isabel B, Astiz S, Bassols A, Gonzalez-Bulnes A (2017) Fetal growth-retardation and brain-sparing by malnutrition are associated to changes in neurotransmitters profile. Int J Dev Neurosci 57:72\u201376. \nhttps:\/\/doi.org\/10.1016\/j.ijdevneu.2017.01.005","journal-title":"Int J Dev Neurosci"},{"key":"1851_CR59","doi-asserted-by":"publisher","first-page":"e0174307","DOI":"10.1371\/journal.pone.0174307","volume":"12","author":"MT Ram\u00edrez-L\u00f3pez","year":"2017","unstructured":"Ram\u00edrez-L\u00f3pez MT, V\u00e1zquez M, Lomazzo E, Hofmann C, Blanco RN, Al\u00e9n F, Ant\u00f3n M, Decara J, Arco R, Orio L, Su\u00e1rez J, Lutz B, G\u00f3mez de Heras R, Bindila L, Rodr\u00edguez de Fonseca F (2017) A moderate diet restriction during pregnancy alters the levels of the endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of the rat offspring in a sex-specific manner. PLoS One 12:e0174307. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0174307","journal-title":"PLoS One"},{"key":"1851_CR60","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0304-3940(84)90493-2","volume":"50","author":"M Frankfurt","year":"1984","unstructured":"Frankfurt M, Fuchs E, Wuttke W (1984) Sex differences in \u03b3-aminobutyric acid and glutamate concentration in discrete rat brain nuclei. Neurosci Lett 50:245\u2013250. \nhttps:\/\/doi.org\/10.1016\/0304-3940(84)90493-2","journal-title":"Neurosci Lett"},{"key":"1851_CR61","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1530\/JOE-14-0600","volume":"224","author":"NS Dellschaft","year":"2015","unstructured":"Dellschaft NS, Alexandre-Gouabau MC, Gardner DS, Antignac JP, Keisler DH, Budge H, Symonds ME, Sebert SP (2015) Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring. J Endocrinol 224:171\u2013182. \nhttps:\/\/doi.org\/10.1530\/JOE-14-0600","journal-title":"J Endocrinol"},{"issue":"17","key":"1851_CR62","doi-asserted-by":"publisher","first-page":"30313","DOI":"10.1016\/j.neures.2017.11.007","volume":"S0168-0102","author":"M Kobayashi","year":"2017","unstructured":"Kobayashi M, Shimizu-Okabe C, Kim J, Kobayashi S, Matsushita M, Masuzaki H, Takayama C (2017) Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior. Neurosci Res S0168-0102(17):30313\u201330319. \nhttps:\/\/doi.org\/10.1016\/j.neures.2017.11.007","journal-title":"Neurosci Res"},{"key":"1851_CR63","doi-asserted-by":"publisher","first-page":"R1283","DOI":"10.1152\/ajpregu.00148.2006","volume":"291","author":"Z Song","year":"2006","unstructured":"Song Z, Routh VH (2006) Recurrent hypoglycemia reduces the glucose sensitivity of glucose-inhibited neurons in the ventromedial hypothalamus nucleus. Am J Physiol Regul Integr Comp Physiol 291:R1283\u2013R1287. \nhttps:\/\/doi.org\/10.1152\/ajpregu.00148.2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1851_CR64","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.molmet.2016.08.002","volume":"5","author":"AM Santiago","year":"2016","unstructured":"Santiago AM, Clegg DJ, Routh VH (2016) Estrogens modulate ventrolateral ventromedial hypothalamic glucose-inhibited neurons. Mol Metab 5:823\u2013833. \nhttps:\/\/doi.org\/10.1016\/j.molmet.2016.08.002","journal-title":"Mol Metab"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-018-1851-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-018-1851-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-018-1851-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T03:13:46Z","timestamp":1573269226000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-018-1851-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,7]]},"references-count":64,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1851"],"URL":"https:\/\/doi.org\/10.1007\/s00394-018-1851-6","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,7]]},"assertion":[{"value":"21 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}