{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:09:49Z","timestamp":1790417389677,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R03DK099425"],"award-info":[{"award-number":["R03DK099425"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s00394-019-02019-z","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T10:06:46Z","timestamp":1559642806000},"page":"1641-1654","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["High-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice"],"prefix":"10.1007","volume":"59","author":[{"given":"Aaron M.","family":"Magnuson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Regan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea D.","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine K.","family":"Fouts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia M.","family":"Solt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve W.","family":"Dow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3232-6924","authenticated-orcid":false,"given":"Michelle T.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"issue":"6","key":"2019_CR1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/S0165-6147(03)00132-9","volume":"24","author":"M Lafontan","year":"2003","unstructured":"Lafontan M, Berlan M (2003) Do regional differences in adipocyte biology provide new pathophysiological insights? Trends Pharmacol Sci 24(6):276\u2013283. \nhttps:\/\/doi.org\/10.1016\/S0165-6147(03)00132-9","journal-title":"Trends Pharmacol Sci"},{"issue":"6","key":"2019_CR2","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1210\/jc.2006-1811","volume":"92","author":"I Harman-Boehm","year":"2007","unstructured":"Harman-Boehm I, Bl\u00fcher M, Redel H, Sion-Vardy N, Ovadia S, Avinoach E, Shai I, Kl\u00f6ting N, Stumvoll M, Bashan N, Rudich A (2007) Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity. J Clin Endocrinol Metab 92(6):2240\u20132247. \nhttps:\/\/doi.org\/10.1210\/jc.2006-1811","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019_CR3","doi-asserted-by":"publisher","first-page":"R113","DOI":"10.1530\/joe-14-0283","volume":"222","author":"M Mraz","year":"2014","unstructured":"Mraz M, Haluzik M (2014) The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol 222(3):R113\u2013R127. \nhttps:\/\/doi.org\/10.1530\/joe-14-0283","journal-title":"J Endocrinol"},{"issue":"2","key":"2019_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.beem.2013.02.005","volume":"27","author":"M Bl\u00fcher","year":"2013","unstructured":"Bl\u00fcher M (2013) Adipose tissue dysfunction contributes to obesity related metabolic diseases. Best Pract Res Clin Endocrinol Metab 27(2):163\u2013177. \nhttps:\/\/doi.org\/10.1016\/j.beem.2013.02.005","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"9","key":"2019_CR5","doi-asserted-by":"publisher","first-page":"E439","DOI":"10.1002\/oby.20135","volume":"21","author":"IJ Neeland","year":"2013","unstructured":"Neeland IJ, Ayers CR, Rohatgi AK, Turer AT, Berry JD, Das SR, Vega GL, Khera A, McGuire DK, Grundy SM, de Lemos JA (2013) Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults. Obesity 21(9):E439\u2013E447. \nhttps:\/\/doi.org\/10.1002\/oby.20135","journal-title":"Obesity"},{"issue":"3","key":"2019_CR6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000471488","volume":"10","author":"GH Goossens","year":"2017","unstructured":"Goossens GH (2017) The metabolic phenotype in obesity: fat mass, body fat distribution, and adipose tissue function. Obes Facts 10(3):207\u2013215","journal-title":"Obes Facts"},{"issue":"2","key":"2019_CR7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","volume":"105","author":"N Esser","year":"2014","unstructured":"Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N (2014) Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract 105(2):141\u2013150. \nhttps:\/\/doi.org\/10.1016\/j.diabres.2014.04.006","journal-title":"Diabetes Res Clin Pract"},{"issue":"7","key":"2019_CR8","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1161\/atvbaha.108.165100","volume":"28","author":"U Kintscher","year":"2008","unstructured":"Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, Fischer-Posovszky P, Barth TFE, Dragun D, Skurk T, Hauner H, Bl\u00fcher M, Unger T, Wolf A-M, Knippschild U, Hombach V, Marx N (2008) T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 28(7):1304\u20131310. \nhttps:\/\/doi.org\/10.1161\/atvbaha.108.165100","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"2019_CR9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1467-789X.2009.00623.x","volume":"11","author":"MM Ibrahim","year":"2010","unstructured":"Ibrahim MM (2010) Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev 11(1):11\u201318. \nhttps:\/\/doi.org\/10.1111\/j.1467-789X.2009.00623.x","journal-title":"Obes Rev"},{"issue":"1","key":"2019_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1742-4933-2-8","volume":"2","author":"F Licastro","year":"2005","unstructured":"Licastro F, Candore G, Lio D, Porcellini E, Colonna-Romano G, Franceschi C, Caruso C (2005) Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immunity Ageing 2(1):8. \nhttps:\/\/doi.org\/10.1186\/1742-4933-2-8","journal-title":"Immunity Ageing"},{"issue":"5","key":"2019_CR11","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1080\/01926230600867727","volume":"34","author":"CL Willard-Mack","year":"2006","unstructured":"Willard-Mack CL (2006) Normal structure, function, and histology of lymph nodes. Toxicol Pathol 34(5):409\u2013424. \nhttps:\/\/doi.org\/10.1080\/01926230600867727","journal-title":"Toxicol Pathol"},{"key":"2019_CR12","volume-title":"Lymphatics, lymph and the lymphomyeloid complex","author":"JM Yoffey","year":"1970","unstructured":"Yoffey JM, Courtice FC (1970) Lymphatics, lymph and the lymphomyeloid complex. Academic Press, London"},{"issue":"8","key":"2019_CR13","doi-asserted-by":"publisher","first-page":"e70703","DOI":"10.1371\/journal.pone.0070703","volume":"8","author":"ES Weitman","year":"2013","unstructured":"Weitman ES, Aschen SZ, Farias-Eisner G, Albano N, Cuzzone DA, Ghanta S, Zampell JC, Thorek D, Mehrara BJ (2013) Obesity impairs lymphatic fluid transport and dendritic cell migration to lymph nodes. PLoS One 8(8):e70703. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0070703","journal-title":"PLoS One"},{"issue":"5","key":"2019_CR14","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/ijo.2012.98","volume":"37","author":"N Arngrim","year":"2013","unstructured":"Arngrim N, Simonsen L, Holst JJ, Bulow J (2013) Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects: a possible link between obesity and local tissue inflammation[quest]. Int J Obes 37(5):748\u2013750. \nhttps:\/\/doi.org\/10.1038\/ijo.2012.98","journal-title":"Int J Obes"},{"issue":"6","key":"2019_CR15","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/j.1365-2036.2010.04407.x","volume":"32","author":"PY von der Weid","year":"2010","unstructured":"von der Weid PY, Rainey KJ (2010) Review article: lymphatic system and associated adipose tissue in the development of inflammatory bowel disease. Aliment Pharmacol Ther 32(6):697\u2013711. \nhttps:\/\/doi.org\/10.1111\/j.1365-2036.2010.04407.x","journal-title":"Aliment Pharmacol Ther"},{"key":"2019_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/cpr.12365","volume":"50","author":"A Magnuson","year":"2017","unstructured":"Magnuson A, Regan D, Fouts J, Booth A, Dow S, Foster M (2017) Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations. Cell Prolif 50:5","journal-title":"Cell Prolif"},{"issue":"45","key":"2019_CR17","doi-asserted-by":"publisher","first-page":"16315","DOI":"10.1073\/pnas.0506190102","volume":"102","author":"KA Soderberg","year":"2005","unstructured":"Soderberg KA, Payne GW, Sato A, Medzhitov R, Segal SS, Iwasaki A (2005) Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci USA 102(45):16315\u201316320. \nhttps:\/\/doi.org\/10.1073\/pnas.0506190102","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"2019_CR18","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/oby.2008.55","volume":"16","author":"CS Kim","year":"2008","unstructured":"Kim CS, Lee SC, Kim YM, Kim BS, Choi HS, Kawada T, Kwon BS, Yu R (2008) Visceral fat accumulation induced by a high-fat diet causes the atrophy of mesenteric lymph nodes in obese mice. Obesity 16(6):1261\u20131269. \nhttps:\/\/doi.org\/10.1038\/oby.2008.55","journal-title":"Obesity"},{"issue":"4","key":"2019_CR19","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.trsl.2014.05.001","volume":"164","author":"M Cavalera","year":"2014","unstructured":"Cavalera M, Wang J, Frangogiannis NG (2014) Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities. Transl Res 164(4):323\u2013335. \nhttps:\/\/doi.org\/10.1016\/j.trsl.2014.05.001","journal-title":"Transl Res"},{"issue":"4","key":"2019_CR20","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1161\/hypertensionaha.113.02419","volume":"63","author":"R Eschalier","year":"2014","unstructured":"Eschalier R, Rossignol P, Kearney-Schwartz A, Adamopoulos C, Karatzidou K, Fay R, Mandry D, Marie PY, Zannad F (2014) Features of cardiac remodeling, associated with blood pressure and fibrosis biomarkers, are frequent in subjects with abdominal obesity. Hypertension (Dallas, Tex: 1979) 63(4):740\u2013746. \nhttps:\/\/doi.org\/10.1161\/hypertensionaha.113.02419","journal-title":"Hypertension (Dallas, Tex: 1979)"},{"issue":"6","key":"2019_CR21","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/S0016-5085(00)70364-7","volume":"118","author":"V Ratziu","year":"2000","unstructured":"Ratziu V, Giral P, Charlotte F, Bruckert E, Thibault V, Theodorou I, Khalil L, Turpin G, Opolon P, Poynard T (2000) Liver fibrosis in overweight patients. Gastroenterology 118(6):1117\u20131123","journal-title":"Gastroenterology"},{"issue":"1","key":"2019_CR22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/kisup.2014.21","volume":"4","author":"K Sharma","year":"2014","unstructured":"Sharma K (2014) Obesity, oxidative stress, and fibrosis in chronic kidney disease. Kidney Int Suppl 4(1):113\u2013117. \nhttps:\/\/doi.org\/10.1038\/kisup.2014.21","journal-title":"Kidney Int Suppl"},{"issue":"6","key":"2019_CR23","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1172\/JCI45887","volume":"121","author":"K Sun","year":"2011","unstructured":"Sun K, Kusminski CM, Scherer PE (2011) Adipose tissue remodeling and obesity. J Clin Investig 121(6):2094","journal-title":"J Clin Investig"},{"issue":"1","key":"2019_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/obr.12229","volume":"16","author":"S O\u2019neill","year":"2015","unstructured":"O\u2019neill S, O\u2019driscoll L (2015) Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obes Rev 16(1):1\u201312","journal-title":"Obes Rev"},{"issue":"12","key":"2019_CR25","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.2337\/diacare.14.12.1132","volume":"14","author":"P Bj\u00f6rntorp","year":"1991","unstructured":"Bj\u00f6rntorp P (1991) Metabolic implications of body fat distribution. Diabetes Care 14(12):1132\u20131143","journal-title":"Diabetes Care"},{"key":"2019_CR26","doi-asserted-by":"publisher","first-page":"291546","DOI":"10.1155\/2013\/291546","volume":"2013","author":"G De Pergola","year":"2013","unstructured":"De Pergola G, Silvestris F (2013) Obesity as a major risk factor for cancer. J Obes 2013:291546. \nhttps:\/\/doi.org\/10.1155\/2013\/291546","journal-title":"J Obes"},{"issue":"8","key":"2019_CR27","first-page":"2258","volume":"7","author":"NA Bilecik","year":"2014","unstructured":"Bilecik NA, Tuna S, Samanc\u0131 N, Balc\u0131 N, Akba\u015f H (2014) Prevalence of metabolic syndrome in women with rheumatoid arthritis and effective factors. Int J Clin Exp Med 7(8):2258\u20132265","journal-title":"Int J Clin Exp Med"},{"issue":"2","key":"2019_CR28","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/ajg.2014.422","volume":"110","author":"CG Lee","year":"2015","unstructured":"Lee CG, Lee JK, Kang Y-S, Shin S, Kim JH, Lim YJ, Koh M-S, Lee JH, Kang HW (2015) Visceral abdominal obesity is associated with an increased risk of irritable bowel syndrome. Am J Gastroenterol 110(2):310","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"2019_CR29","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/oby.2006.43","volume":"14","author":"JL Kuk","year":"2006","unstructured":"Kuk JL, Katzmarzyk PT, Nichaman MZ, Church TS, Blair SN, Ross R (2006) Visceral fat is an independent predictor of all-cause mortality in men. Obesity 14(2):336\u2013341","journal-title":"Obesity"},{"issue":"16","key":"2019_CR30","doi-asserted-by":"publisher","first-page":"4467","DOI":"10.1128\/mcb.00192-09","volume":"29","author":"N Halberg","year":"2009","unstructured":"Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, Scherer PE (2009) Hypoxia-inducible factor 1\u03b1 induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 29(16):4467\u20134483. \nhttps:\/\/doi.org\/10.1128\/mcb.00192-09","journal-title":"Mol Cell Biol"},{"issue":"4","key":"2019_CR31","doi-asserted-by":"publisher","first-page":"E1118","DOI":"10.1152\/ajpendo.00435.2007","volume":"293","author":"J Ye","year":"2007","unstructured":"Ye J, Gao Z, Yin J, He Q (2007) Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob\/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293(4):E1118\u2013E1128. \nhttps:\/\/doi.org\/10.1152\/ajpendo.00435.2007","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"2019_CR32","doi-asserted-by":"publisher","first-page":"901","DOI":"10.2337\/db06-0911","volume":"56","author":"N Hosogai","year":"2007","unstructured":"Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M, Shimomura I (2007) Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56(4):901\u2013911. \nhttps:\/\/doi.org\/10.2337\/db06-0911","journal-title":"Diabetes"},{"issue":"5","key":"2019_CR33","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1128\/CVI.13.5.556-560.2006","volume":"13","author":"TW Schacker","year":"2006","unstructured":"Schacker TW, Brenchley JM, Beilman GJ, Reilly C, Pambuccian SE, Taylor J, Skarda D, Larson M, Douek DC, Haase AT (2006) Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection. Clin Vaccine Immunol 13(5):556\u2013560","journal-title":"Clin Vaccine Immunol"},{"issue":"1","key":"2019_CR34","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/imr.12079","volume":"254","author":"M Paiardini","year":"2013","unstructured":"Paiardini M, Muller-Trutwin M (2013) HIV-associated chronic immune activation. Immunol Rev 254(1):78\u2013101. \nhttps:\/\/doi.org\/10.1111\/imr.12079","journal-title":"Immunol Rev"},{"issue":"3","key":"2019_CR35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/cmi.2013.11","volume":"10","author":"N Niu","year":"2013","unstructured":"Niu N, Qin X (2013) New insights into IL-7 signaling pathways during early and late T cell development. Cell Mol Immunol 10(3):187\u2013189. \nhttps:\/\/doi.org\/10.1038\/cmi.2013.11","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"2019_CR36","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.4049\/jimmunol.1402520","volume":"194","author":"FD Brown","year":"2015","unstructured":"Brown FD, Turley SJ (2015) Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle. J Immunol 194(4):1389\u20131394. \nhttps:\/\/doi.org\/10.4049\/jimmunol.1402520","journal-title":"J Immunol"},{"issue":"3 Pt 1","key":"2019_CR37","first-page":"G384","volume":"261","author":"PR Kvietys","year":"1991","unstructured":"Kvietys PR, Specian RD, Grisham MB, Tso P (1991) Jejunal mucosal injury and restitution: role of hydrolytic products of food digestion. Am J Physiol 261(3 Pt 1):G384\u2013G391","journal-title":"Am J Physiol"},{"issue":"8","key":"2019_CR38","doi-asserted-by":"publisher","first-page":"e12191","DOI":"10.1371\/journal.pone.0012191","volume":"5","author":"S Ding","year":"2010","unstructured":"Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NM, Magness S, Jobin C, Lund PK (2010) High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One 5(8):e12191. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0012191","journal-title":"PLoS One"},{"issue":"7\u20138","key":"2019_CR39","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.nut.2015.02.006","volume":"31","author":"I Novotny Nunez","year":"2015","unstructured":"Novotny Nunez I, Maldonado Galdeano C, de Moreno de LeBlanc A, Perdigon G (2015) Lactobacillus casei CRL 431 administration decreases inflammatory cytokines in a diet-induced obese mouse model. Nutrition 31(7\u20138):1000\u20131007. \nhttps:\/\/doi.org\/10.1016\/j.nut.2015.02.006","journal-title":"Nutrition"},{"issue":"11","key":"2019_CR40","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1093\/jn\/131.11.2943","volume":"131","author":"H Yoshida","year":"2001","unstructured":"Yoshida H, Miura S, Kishikawa H, Hirokawa M, Nakamizo H, Nakatsumi RC, Suzuki H, Saito H, Ishii H (2001) Fatty acids enhance GRO\/CINC-1 and interleukin-6 production in rat intestinal epithelial cells. J Nutr 131(11):2943\u20132950","journal-title":"J Nutr"},{"issue":"12","key":"2019_CR41","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1111\/j.1440-1746.1998.tb00602.x","volume":"13","author":"S Miura","year":"1998","unstructured":"Miura S, Tsuzuki Y, Hokari R, Ishii H (1998) Modulation of intestinal immune system by dietary fat intake: relevance to Crohn\u2019s disease. J Gastroenterol Hepatol 13(12):1183\u20131190","journal-title":"J Gastroenterol Hepatol"},{"issue":"5","key":"2019_CR42","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/ijo.2012.98","volume":"37","author":"N Arngrim","year":"2013","unstructured":"Arngrim N, Simonsen L, Holst JJ, Bulow J (2013) Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects: a possible link between obesity and local tissue inflammation? Int J Obes (Lond) 37(5):748\u2013750. \nhttps:\/\/doi.org\/10.1038\/ijo.2012.98","journal-title":"Int J Obes (Lond)"},{"issue":"3","key":"2019_CR43","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1084\/jem.191.3.435","volume":"191","author":"FP Huang","year":"2000","unstructured":"Huang FP, Platt N, Wykes M, Major JR, Powell TJ, Jenkins CD, MacPherson GG (2000) A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med 191(3):435\u2013444","journal-title":"J Exp Med"},{"issue":"5","key":"2019_CR44","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1053\/j.gastro.2011.06.057","volume":"141","author":"JJ Worthington","year":"2011","unstructured":"Worthington JJ, Czajkowska BI, Melton AC, Travis MA (2011) Intestinal dendritic cells specialize to activate transforming growth factor-beta and induce Foxp3+ regulatory T cells via integrin alphavbeta8. Gastroenterology 141(5):1802\u20131812. \nhttps:\/\/doi.org\/10.1053\/j.gastro.2011.06.057","journal-title":"Gastroenterology"},{"issue":"2\u20133","key":"2019_CR45","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.1365-3083.2007.01975.x","volume":"66","author":"JB Sun","year":"2007","unstructured":"Sun JB, Czerkinsky C, Holmgren J (2007) Sublingual \u2018oral tolerance\u2019 induction with antigen conjugated to cholera toxin B subunit generates regulatory T cells that induce apoptosis and depletion of effector T cells. Scand J Immunol 66(2\u20133):278\u2013286. \nhttps:\/\/doi.org\/10.1111\/j.1365-3083.2007.01975.x","journal-title":"Scand J Immunol"},{"issue":"2","key":"2019_CR46","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.immuni.2011.01.016","volume":"34","author":"U Hadis","year":"2011","unstructured":"Hadis U, Wahl B, Schulz O, Hardtke-Wolenski M, Schippers A, Wagner N, Muller W, Sparwasser T, Forster R, Pabst O (2011) Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 34(2):237\u2013246. \nhttps:\/\/doi.org\/10.1016\/j.immuni.2011.01.016","journal-title":"Immunity"},{"issue":"3","key":"2019_CR47","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1084\/jem.20052016","volume":"203","author":"T Worbs","year":"2006","unstructured":"Worbs T, Bode U, Yan S, Hoffmann MW, Hintzen G, Bernhardt G, Forster R, Pabst O (2006) Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med 203(3):519\u2013527. \nhttps:\/\/doi.org\/10.1084\/jem.20052016","journal-title":"J Exp Med"},{"issue":"13","key":"2019_CR48","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1084\/jem.20091925","volume":"206","author":"O Schulz","year":"2009","unstructured":"Schulz O, Jaensson E, Persson EK, Liu X, Worbs T, Agace WW, Pabst O (2009) Intestinal CD103+, but not CX3CR51+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med 206(13):3101\u20133114. \nhttps:\/\/doi.org\/10.1084\/jem.20091925","journal-title":"J Exp Med"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-019-02019-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00394-019-02019-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-019-02019-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T16:29:39Z","timestamp":1589646579000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00394-019-02019-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["2019"],"URL":"https:\/\/doi.org\/10.1007\/s00394-019-02019-z","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,4]]},"assertion":[{"value":"27 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}