{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:52:46Z","timestamp":1790473966468,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Artificially sweetened and sugar-sweetened beverage consumptions have both been reported to be associated with type 2 diabetes mellitus (T2D) risk. The aim of the current study was to investigate the potential underlying associations with dynamic pancreatic \u03b2-cell function (BCF) and insulin sensitivity.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We evaluated cross-sectional associations in 2240 individuals (mean\u2009\u00b1\u2009SD age 59.6\u2009\u00b1\u20098.18, 49.4% male, 21.9% T2D) participating in a diabetes-enriched population-based cohort. Artificially sweetened and sugar-sweetened soft drinks and juice consumption were assessed by a food-frequency questionnaire. Glucose metabolism status, insulin sensitivity, and BCF were measured by a seven-point oral glucose tolerance test. Regression analyses were performed to assess associations of artificially and sugar-sweetened beverage consumption with measures of glucose homeostasis. Associations were adjusted for potential confounders, and additionally with and without total energy intake and BMI, as these variables could be mediators.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Moderate consumption of artificially sweetened soft drink was associated with lower \u03b2-cell glucose sensitivity [standardized beta (95% CI), \u2212\u20090.06 (\u2212\u20090.11, \u2212\u20090.02)], total insulin secretion [<jats:italic>\u03b2<\/jats:italic> \u2212\u20090.06 (\u2212\u20090.10, \u2212\u20090.02)], and with lower \u03b2-cell rate sensitivity [odds ratio (95% CI), 1.29 (1.03, 1.62)] compared to abstainers. Daily artificially sweetened soft drink consumption was associated with lower \u03b2-cell glucose sensitivity [<jats:italic>\u03b2<\/jats:italic> \u2212\u20090.05 (\u2212\u20090.09, 0.00)], and total insulin secretion [<jats:italic>\u03b2<\/jats:italic> \u2212\u20090.05 \u2212\u20090.09, \u2212\u20090.01)] compared to abstainers.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Moderate and daily consumption of artificially sweetened soft drinks was associated with lower BCF, but not with insulin sensitivity. No evidence was found for associations of sugar-sweetened soft drink and juice consumption with BCF or insulin sensitivity in this middle-aged population. Prospective studies are warranted to further investigate the associations of artificially and sugar-sweetened beverage consumption with non-fasting insulin sensitivity and multiple BCF aspects.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00394-019-02026-0","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T14:21:37Z","timestamp":1568038897000},"page":"1717-1727","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Association of artificially sweetened and sugar-sweetened soft drinks with \u03b2-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study"],"prefix":"10.1007","volume":"59","author":[{"given":"Louise J. C. J.","family":"den Biggelaar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone J. 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