{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:50:36Z","timestamp":1776873036022,"version":"3.51.2"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Health Department of the Government of Navarra","award":["61\/2015"],"award-info":[{"award-number":["61\/2015"]}]},{"DOI":"10.13039\/501100012514","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red-Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n","doi-asserted-by":"publisher","award":["CB12\/03\/3002"],"award-info":[{"award-number":["CB12\/03\/3002"]}],"id":[{"id":"10.13039\/501100012514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","award":["FPU17\/06330"],"award-info":[{"award-number":["FPU17\/06330"]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s00394-020-02370-6","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T12:02:54Z","timestamp":1598616174000},"page":"1769-1780","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Dietary intake of specific amino acids and liver status in subjects with nonalcoholic fatty liver disease: fatty liver in obesity (FLiO) study"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9906-9996","authenticated-orcid":false,"given":"Cristina","family":"Galarregui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3468-8045","authenticated-orcid":false,"given":"Irene","family":"Cantero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertha Araceli","family":"Marin-Alejandre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Ignacio","family":"Monreal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Elorz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1527-0092","authenticated-orcid":false,"given":"Alberto","family":"Benito-Boillos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-3073","authenticated-orcid":false,"given":"Jos\u00e9 Ignacio","family":"Herrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"de la O","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7684-2787","authenticated-orcid":false,"given":"Miguel","family":"Ruiz-Canela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4441-6572","authenticated-orcid":false,"given":"Helen Hermana M.","family":"Hermsdorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-9436","authenticated-orcid":false,"given":"Josefina","family":"Bressan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6940-0761","authenticated-orcid":false,"given":"Josep A.","family":"Tur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-6941","authenticated-orcid":false,"given":"J. Alfredo","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3926-0892","authenticated-orcid":false,"given":"M. Angeles","family":"Zulet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6475-5387","authenticated-orcid":false,"given":"Itziar","family":"Abete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"2370_CR1","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/hep.29367","volume":"67","author":"N Chalasani","year":"2018","unstructured":"Chalasani N, Younossi Z, Lavine JE et al (2018) The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology 67:328\u2013357","journal-title":"Hepatology"},{"key":"2370_CR2","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1016\/j.cgh.2015.07.029","volume":"13","author":"A Ahmed","year":"2015","unstructured":"Ahmed A, Wong RJ, Harrison SA (2015) Nonalcoholic fatty liver disease review: diagnosis, treatment, and outcomes. Clin Gastroenterol Hepato 13:2062\u20132070. https:\/\/doi.org\/10.1016\/j.cgh.2015.07.029","journal-title":"Clin Gastroenterol Hepato"},{"key":"2370_CR3","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/j.clnu.2017.06.027","volume":"37","author":"I Cantero","year":"2018","unstructured":"Cantero I, Abete I, Babio N et al (2018) Dietary inflammatory index and liver status in subjects with different adiposity levels within the PREDIMED trial. Clin Nutr 37:1736\u20131743. https:\/\/doi.org\/10.1016\/j.clnu.2017.06.027","journal-title":"Clin Nutr"},{"key":"2370_CR4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00018-018-2947-0","volume":"76","author":"F Bessone","year":"2019","unstructured":"Bessone F, Razori MV, Roma MG (2019) Molecular pathways of nonalcoholic fatty liver disease development and progression. Cell Mol Life Sci 76:99\u2013128","journal-title":"Cell Mol Life Sci"},{"key":"2370_CR5","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","volume":"62","author":"CD Byrne","year":"2015","unstructured":"Byrne CD, Targher G (2015) NAFLD: a multisystem disease. J Hepatol 62:S47\u2013S64","journal-title":"J Hepatol"},{"key":"2370_CR6","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1146\/annurev-physiol-021115-105331","volume":"78","author":"JT Haas","year":"2016","unstructured":"Haas JT, Francque S, Staels B (2016) Pathophysiology and mechanisms of nonalcoholic fatty liver disease. Annu Rev Physiol 78:181\u2013205. https:\/\/doi.org\/10.1146\/annurev-physiol-021115-105331","journal-title":"Annu Rev Physiol"},{"key":"2370_CR7","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1002\/hep.25772","volume":"56","author":"R Loomba","year":"2012","unstructured":"Loomba R, Abraham M, Unalp A et al (2012) Nonalcoholic steatohepatitis clinical research network. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology 56:943\u2013951. https:\/\/doi.org\/10.1002\/hep.25772","journal-title":"Hepatology"},{"key":"2370_CR8","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.clnu.2011.02.009","volume":"30","author":"P Tessari","year":"2011","unstructured":"Tessari P, Cecchet D, Cosma A et al (2011) Insulin resistance of amino acid and protein metabolism in type 2 diabetes. Clin Nutr 30:267\u2013372. https:\/\/doi.org\/10.1016\/j.clnu.2011.02.009","journal-title":"Clin Nutr"},{"key":"2370_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s12328-018-0841-9","volume":"11","author":"Y Seko","year":"2018","unstructured":"Seko Y, Yamaguchi K, Itoh Y (2018) The genetic backgrounds in nonalcoholic fatty liver disease. Clin J Gastroenterol 11:97\u2013102","journal-title":"Clin J Gastroenterol"},{"key":"2370_CR10","first-page":"1","volume":"11","author":"BA Marin-Alejandre","year":"2019","unstructured":"Marin-Alejandre BA, Abete I, Cantero I et al (2019) Association between sleep disturbances and liver status in obese subjects with nonalcoholic fatty liver disease: a comparison with healthy controls. Nutrients 11:1\u201316","journal-title":"Nutrients"},{"key":"2370_CR11","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s41569-018-0026-8","volume":"15","author":"L Fontana","year":"2018","unstructured":"Fontana L (2018) Interventions to promote cardiometabolic health and slow cardiovascular ageing. Nat Rev Cardiol 15:566\u2013577","journal-title":"Nat Rev Cardiol"},{"key":"2370_CR12","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1089\/ars.2016.6776","volume":"26","author":"S Spahis","year":"2017","unstructured":"Spahis S, Delvin E, Borys JM et al (2017) Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis. Antioxidants Redox Signal 26:519\u2013541. https:\/\/doi.org\/10.1089\/ars.2016.6776","journal-title":"Antioxidants Redox Signal"},{"key":"2370_CR13","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8162421","author":"A Alisi","year":"2017","unstructured":"Alisi A, Carpino G, Oliveira FL et al (2017) The role of tissue macrophage-mediated inflammation on NAFLD pathogenesis and its clinical implications. Med Inflamm. https:\/\/doi.org\/10.1155\/2017\/8162421","journal-title":"Med Inflamm"},{"key":"2370_CR14","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.3390\/nu11102543","volume":"11","author":"BA Marin-Alejandre","year":"2019","unstructured":"Marin-Alejandre BA, Abete I, Cantero I et al (2019) The metabolic and hepatic impact of two personalized dietary strategies in subjects with obesity and nonalcoholic fatty liver disease: the fatty liver in obesity (FLiO) randomized controlled trial. Nutrients 11:2543. https:\/\/doi.org\/10.3390\/nu11102543","journal-title":"Nutrients"},{"key":"2370_CR15","first-page":"1","volume":"11","author":"R Sch\u00fcbel","year":"2019","unstructured":"Sch\u00fcbel R, Nonnenmacher T, Sookthai D et al (2019) Similar weight loss induces greater improvements in insulin sensitivity and liver function among individuals with NAFLD compared to individuals without NAFLD. Nutrients 11:1\u201312","journal-title":"Nutrients"},{"key":"2370_CR16","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00394012-0355-z","volume":"52","author":"V Volynets","year":"2013","unstructured":"Volynets V, Machann J, K\u00fcper MA et al (2013) A moderate weight reduction through dietary intervention decreases hepatic fat content in patients with non-alcoholic fatty liver disease (NAFLD): a pilot study. Eur J Nutr 52:527\u2013535. https:\/\/doi.org\/10.1007\/s00394012-0355-z","journal-title":"Eur J Nutr"},{"key":"2370_CR17","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.3390\/nu11102359","volume":"11","author":"G Recaredo","year":"2019","unstructured":"Recaredo G, Marin-Alejandre BA, Cantero I et al (2019) Association between different animal protein sources and liver status in obese subjects with non-alcoholic fatty liver disease: fatty liver in obesity (FLiO) study. Nutrients 11:2359. https:\/\/doi.org\/10.3390\/nu11102359","journal-title":"Nutrients"},{"key":"2370_CR18","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1017\/S000711451800137X","volume":"120","author":"CN Katsagoni","year":"2018","unstructured":"Katsagoni CN, Papatheodoridis GV, Ioannidou P et al (2018) Improvements in clinical characteristics of patients with non-alcoholic fatty liver disease, after an intervention based on the Mediterranean lifestyle: a randomised controlled clinical trial. Br J Nutr 120:164\u2013175","journal-title":"Br J Nutr"},{"key":"2370_CR19","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/advances\/nmz023","volume":"10","author":"DL Katz","year":"2019","unstructured":"Katz DL, Doughty KN, Geagan K et al (2019) Perspective: the public health case for modernizing the definition of protein quality. Adv Nutr 10:755\u2013764","journal-title":"Adv Nutr"},{"key":"2370_CR20","doi-asserted-by":"publisher","first-page":"16838","DOI":"10.1038\/s41598-017-17047-0","volume":"4","author":"F Teymoori","year":"2017","unstructured":"Teymoori F, Asghari G, Mirmiran P et al (2017) Dietary amino acids and incidence of hypertension: a principle component analysis approach. Sci Rep 4:16838. https:\/\/doi.org\/10.1038\/s41598-017-17047-0","journal-title":"Sci Rep"},{"key":"2370_CR21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5041\/RMMJ.10337","volume":"9","author":"C Grajeda-Iglesias","year":"2018","unstructured":"Grajeda-Iglesias C, Aviram M (2018) Specific amino acids affect cardiovascular diseases and atherogenesis via protection against macrophage foam cell formation: review article. Rambam Maimonides Med J 9:3. https:\/\/doi.org\/10.5041\/RMMJ.10337","journal-title":"Rambam Maimonides Med J"},{"key":"2370_CR22","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1007\/s00394-017-1533-9","volume":"57","author":"SE Hanvold","year":"2018","unstructured":"Hanvold SE, Vinknes KJ, Bastani NE et al (2018) Plasma amino acids, adiposity, and weight change after gastric bypass surgery: are amino acids associated with weight regain? Eur J Nutr 57:2629\u20132637. https:\/\/doi.org\/10.1007\/s00394-017-1533-9","journal-title":"Eur J Nutr"},{"key":"2370_CR23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/hep.29465","volume":"67","author":"M Gaggini","year":"2018","unstructured":"Gaggini M, Carli F, Rosso C et al (2018) Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance. Hepatology 67:145\u2013158. https:\/\/doi.org\/10.1002\/hep.29465","journal-title":"Hepatology"},{"key":"2370_CR24","doi-asserted-by":"publisher","first-page":"8334","DOI":"10.3390\/molecules19068334","volume":"19","author":"JI Toohey","year":"2014","unstructured":"Toohey JI (2014) Sulfur amino acids in diet-induced fatty liver: A new perspective based on recent findings. Molecules 19:8334\u20138349. https:\/\/doi.org\/10.3390\/molecules19068334","journal-title":"Molecules"},{"key":"2370_CR25","doi-asserted-by":"publisher","first-page":"7392","DOI":"10.3748\/wjg.v20.i23.7392","volume":"20","author":"SS Lee","year":"2014","unstructured":"Lee SS, Park SH (2014) Radiologic evaluation of nonalcoholic fatty liver disease. World J Gastroenterol 20:7392\u20137402","journal-title":"World J Gastroenterol"},{"key":"2370_CR26","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/hep.24376","volume":"54","author":"AJ Sanyal","year":"2011","unstructured":"Sanyal AJ, Brunt EM, Kleiner DE et al (2011) Endpoints and clinical trial design for nonalcoholic steatohepatitis. Hepatology 54:344\u2013353","journal-title":"Hepatology"},{"key":"2370_CR27","first-page":"16","volume":"26","author":"MA Zulet","year":"2011","unstructured":"Zulet MA, Bondia-Pons I, Abete I et al (2011) The reduction of the metabolic syndrome in Navarra-Spain (RESMENA S) study: a multidisciplinary strategy based on chrononutrition and nutritional education, together with dietetic and psychological control. Nutr Hosp 26:16\u201326","journal-title":"Nutr Hosp"},{"key":"2370_CR28","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"WT Friedewald","year":"1972","unstructured":"Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499\u2013502","journal-title":"Clin Chem"},{"key":"2370_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4067\/S0034-98872002001100004","volume":"130","author":"AM Acosta","year":"2002","unstructured":"Acosta AM, Escalona M, Maiz A (2002) Determinaci\u00f3n del \u00edndice de resistencia insul\u00ednica mediante HOMA en una poblaci\u00f3n de la Regi\u00f3n Metropolitana de Chile. Rev M\u00e9d Chile 130:17","journal-title":"Rev M\u00e9d Chile"},{"key":"2370_CR30","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ypmed.2016.01.022","volume":"86","author":"D Navarro-Gonz\u00e1lez","year":"2016","unstructured":"Navarro-Gonz\u00e1lez D, S\u00e1nchez-\u00cd\u00f1igo L, Pastrana-Delgado J et al (2016) Triglyceride-glucose index (TyG index) in comparison with fasting plasma glucose improved diabetes prediction in patients with normal fasting glucose: the Vascular-Metabolic CUN cohort. Prev Med (Baltim) 86:99\u2013105. https:\/\/doi.org\/10.1016\/j.ypmed.2016.01.022","journal-title":"Prev Med (Baltim)"},{"key":"2370_CR31","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1148\/radiol.252308208488","volume":"252","author":"N Pineda","year":"2009","unstructured":"Pineda N, Sharma P, Xu Q et al (2009) Measurement of hepatic lipid: High-speed T2-corrected multiecho acquisition at 1H MR spectroscopy - a rapid and accurate technique. Radiology 252:568\u2013576. https:\/\/doi.org\/10.1148\/radiol.252308208488","journal-title":"Radiology"},{"key":"2370_CR32","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/22.3.512","volume":"22","author":"JM Martin-Moreno","year":"1993","unstructured":"Martin-Moreno JM, Boyle P, Gorgojo L et al (1993) Development and validation of a food frequency questionnaire in Spain. Int J Epidemiol 22:512\u2013519","journal-title":"Int J Epidemiol"},{"key":"2370_CR33","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1017\/S0007114509993837","volume":"103","author":"JD Fern\u00e1ndez-Ballart","year":"2010","unstructured":"Fern\u00e1ndez-Ballart JD, Pi\u00f1ol JL, Zazpe I et al (2010) Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain. Br J Nutr 103:1808\u20131816","journal-title":"Br J Nutr"},{"key":"2370_CR34","volume-title":"Food Composition and Nutrition Tables","author":"SW Souci","year":"2008","unstructured":"Souci SW, Fachmann W, Kraut H (2008) Food Composition and Nutrition Tables. Medpharm, Swedon"},{"key":"2370_CR35","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.clnu.2013.11.011","volume":"33","author":"A Perez-Cornago","year":"2014","unstructured":"Perez-Cornago A, Lopez-Legarrea P, de la Iglesia R et al (2014) Longitudinal relationship of diet and oxidative stress with depressive symptoms in patients with metabolic s\u00edndrome after following a weight loss treatment: the RESMENA project. Clin Nutr 33:1061\u20131067. https:\/\/doi.org\/10.1016\/j.clnu.2013.11.011","journal-title":"Clin Nutr"},{"key":"2370_CR36","doi-asserted-by":"publisher","first-page":"E3662","DOI":"10.3390\/ijms19113662","volume":"19","author":"C Galarregui","year":"2018","unstructured":"Galarregui C, Zulet MA, Cantero I et al (2018) Interplay of glycemic index, glycemic load, and dietary antioxidant capacity with insulin resistance in subjects with a cardiometabolic risk profile. Int J Mol Sci 19:E3662. https:\/\/doi.org\/10.3390\/ijms19113662","journal-title":"Int J Mol Sci"},{"key":"2370_CR37","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1007\/s00394-018-1778-y","volume":"58","author":"D Tric\u00f2","year":"2019","unstructured":"Tric\u00f2 D, Frascerra S, Baldi S et al (2019) The insulinotropic effect of a high-protein nutrient preload is mediated by the increase of plasma amino acids in type 2 diabetes. Eur J Nutr 58:2253\u20132261. https:\/\/doi.org\/10.1007\/s00394-018-1778-y","journal-title":"Eur J Nutr"},{"key":"2370_CR38","volume-title":"Subcommittee on the Tenth Edition of the Recommended Dietary Allowances Protein and Amino Acids","author":"National Research Council (US)","year":"1989","unstructured":"National Research Council (US) (1989) Subcommittee on the Tenth Edition of the Recommended Dietary Allowances Protein and Amino Acids. Recommended Dietary Allowances, Washington DC"},{"key":"2370_CR39","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ebiom.2016.10.013","volume":"13","author":"F Zhang","year":"2016","unstructured":"Zhang F, Zhao S, Yan W et al (2016) Branched chain amino acids cause liver injury in obese\/diabetic mice by promoting adipocyte lipolysis and inhibiting hepatic autophagy. EBioMedicine 13:157\u2013167. https:\/\/doi.org\/10.1016\/j.ebiom.2016.10.013","journal-title":"EBioMedicine"},{"key":"2370_CR40","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1017\/S0007114517001568","volume":"117","author":"M Isanejad","year":"2017","unstructured":"Isanejad M, LaCroix AZ, Thomson CA et al (2017) Branched-chain amino acid, meat intake and risk of type 2 diabetes in the Women\u2019s Health Initiative. Br J Nutr 117:1523\u20131530","journal-title":"Br J Nutr"},{"key":"2370_CR41","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1007\/s00394-018-1882-z","volume":"58","author":"PL Valenzuela","year":"2019","unstructured":"Valenzuela PL, Morales JS, Emanuele E et al (2019) Supplements with purported effects on muscle mass and strength. Eur J Nutr 58:2983\u20133008. https:\/\/doi.org\/10.1007\/s00394-018-1882-z","journal-title":"Eur J Nutr"},{"key":"2370_CR42","doi-asserted-by":"publisher","first-page":"390","DOI":"10.3389\/fphys.2017.00390","volume":"8","author":"SR Jackman","year":"2017","unstructured":"Jackman SR, Witard OC, Philp A et al (2017) Branched-chain amino acid ingestion stimulates muscle myofibrillar protein synthesis following resistance exercise in humans. Front Physiol 8:390","journal-title":"Front Physiol"},{"key":"2370_CR43","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1007\/s00535-015-1067-y","volume":"50","author":"T Beppu","year":"2015","unstructured":"Beppu T, Nitta H, Hayashi H et al (2015) Effect of branched-chain amino acid supplementation on functional liver regeneration in patients undergoing portal vein embolization and sequential hepatectomy: a randomized controlled trial. J Gastroenterol 50:1197\u20131205. https:\/\/doi.org\/10.1007\/s00535-015-1067-y","journal-title":"J Gastroenterol"},{"key":"2370_CR44","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/wsbm.1219","volume":"5","author":"JSA Mattick","year":"2013","unstructured":"Mattick JSA, Kamisoglu K, Ierapetritou MG et al (2013) Branched-chain amino acid supplementation: impact on signaling and relevance to critical illness. Wiley Interdiscip Rev Syst Biol Med 5:449\u2013460. https:\/\/doi.org\/10.1002\/wsbm.1219","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"2370_CR45","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.metabol.2016.12.013","volume":"69","author":"T Honda","year":"2016","unstructured":"Honda T, Ishigami M, Luo F et al (2016) Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. Metabolism 69:177\u2013187. https:\/\/doi.org\/10.1016\/j.metabol.2016.12.013","journal-title":"Metabolism"},{"key":"2370_CR46","doi-asserted-by":"publisher","first-page":"18191","DOI":"10.18632\/oncotarget.15304","volume":"8","author":"K Takegoshi","year":"2017","unstructured":"Takegoshi K, Honda M, Okada H et al (2017) Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model. Oncotarget 8:18191\u201318205. https:\/\/doi.org\/10.18632\/oncotarget.15304","journal-title":"Oncotarget"},{"key":"2370_CR47","doi-asserted-by":"publisher","first-page":"e77899","DOI":"10.1371\/journal.pone.0077899","volume":"8","author":"JH Cha","year":"2013","unstructured":"Cha JH, Bae SH, Kim HL et al (2013) Branched-chain amino acids ameliorate fibrosis and suppress tumor growth in a rat model of hepatocellular carcinoma with liver cirrhosis. PLoS ONE 8:e77899. https:\/\/doi.org\/10.1371\/journal.pone.0077899","journal-title":"PLoS ONE"},{"key":"2370_CR48","first-page":"1","volume":"1","author":"E Buzzetti","year":"2019","unstructured":"Buzzetti E, Petta S, Manuguerra R et al (2019) Evaluating the association of serum ferritin and hepatic iron with disease severity in non-alcoholic fatty liver disease. Liver Int 1:1\u201310","journal-title":"Liver Int"},{"key":"2370_CR49","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000614","author":"de la OV, Zazpe I, Ruiz-Canela M,","year":"2019","unstructured":"de la OV, Zazpe I, Ruiz-Canela M, (2019) Effect of branched-chain amino acid supplementation, dietary intake and circulating levels in cardiometabolic diseases: an updated review. Curr Opin Clin Nutr Metab Care. https:\/\/doi.org\/10.1097\/MCO.0000000000000614","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2370_CR50","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.numecd.2017.07.006","volume":"27","author":"A Ntzouvani","year":"2017","unstructured":"Ntzouvani A, Nomikos T, Panagiotakos D et al (2017) Amino acid profile and metabolic syndrome in a male Mediterranean population: a cross-sectional study. Nutr Metab Cardiovasc Dis 27:1021\u20131030","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2370_CR51","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.2337\/dc14-3082","volume":"38","author":"JM Fer\u0144andez-Real","year":"2015","unstructured":"Fer\u0144andez-Real JM, Mcclain D, Review MM (2015) Mechanisms linking glucose homeostasis and iron metabolism toward the onset and progression of type 2 diabetes. Diabetes Care 38:2169\u20132176. https:\/\/doi.org\/10.2337\/dc14-3082","journal-title":"Diabetes Care"},{"key":"2370_CR52","doi-asserted-by":"publisher","first-page":"8112","DOI":"10.3748\/wjg.v22.i36.8112","volume":"22","author":"LJ Britton","year":"2016","unstructured":"Britton LJ, Subramaniam VN, Crawford DHG (2016) Iron and non-alcoholic fatty liver disease. World J Gastroenterol 22:8112\u20138122. https:\/\/doi.org\/10.3748\/wjg.v22.i36.8112","journal-title":"World J Gastroenterol"},{"key":"2370_CR53","doi-asserted-by":"publisher","first-page":"90","DOI":"10.15171\/mejdd.2018.96","volume":"10","author":"SR Modares Mousavi","year":"2018","unstructured":"Modares Mousavi SR, Geramizadeh B, Anushiravani A et al (2018) Correlation between serum ferritin level and histopathological disease severity in non-alcoholic fatty liver disease. Middle East J Dig Dis 10:90\u201395","journal-title":"Middle East J Dig Dis"},{"key":"2370_CR54","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1002\/hep4.1190","volume":"2","author":"L Britton","year":"2018","unstructured":"Britton L, Bridle K, Reiling J et al (2018) Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease. Hepatol Commun 2:644\u2013653","journal-title":"Hepatol Commun"},{"key":"2370_CR55","first-page":"1","volume":"13","author":"A McKay","year":"2018","unstructured":"McKay A, Wilman HR, Dennis A et al (2018) Measurement of liver iron by magnetic resonance imaging in the UK Biobank population. PLoS ONE 13:1\u201314","journal-title":"PLoS ONE"},{"key":"2370_CR56","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/nu11010173","volume":"11","author":"M Rousseau","year":"2019","unstructured":"Rousseau M, Gu\u00e9nard F, Garneau V et al (2019) Associations between dietary protein sources, plasma BCAA and short-chain acylcarnitine levels in adults. Nutrients 11:5. https:\/\/doi.org\/10.3390\/nu11010173","journal-title":"Nutrients"},{"key":"2370_CR57","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nrendo.2014.171","volume":"10","author":"CJ Lynch","year":"2014","unstructured":"Lynch CJ, Adams SH (2014) Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol 10:723\u2013736","journal-title":"Nat Rev Endocrinol"},{"key":"2370_CR58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17710-6","author":"M Mahbub","year":"2017","unstructured":"Mahbub M, Yamaguchi N, Takahashi H et al (2017) Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-017-17710-6","journal-title":"Sci Rep"},{"key":"2370_CR59","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030705","author":"EH van den Berg","year":"2019","unstructured":"van den Berg EH, Flores-Guerrero JL, Gruppen EG et al (2019) Non-alcoholic fatty liver disease and risk of incident type 2 diabetes: Role of circulating branched-chain amino acids. Nutrients. https:\/\/doi.org\/10.3390\/nu11030705","journal-title":"Nutrients"},{"key":"2370_CR60","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.bbrc.2003.07.012","volume":"313","author":"AJ Meijer","year":"2004","unstructured":"Meijer AJ, Dubbelhuis PF (2004) Amino acid signalling and the integration of metabolism. Biochem Biophys Res Commun 313:397\u2013403. https:\/\/doi.org\/10.1016\/j.bbrc.2003.07.012","journal-title":"Biochem Biophys Res Commun"},{"key":"2370_CR61","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1007\/s00125-018-4611-5","volume":"61","author":"M Ruiz-Canela","year":"2018","unstructured":"Ruiz-Canela M, Guasch-Ferre M, Toledo E et al (2018) Plasma branched chain\/ aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial. Diabetologia 61:1560\u20131571","journal-title":"Diabetologia"},{"key":"2370_CR62","doi-asserted-by":"publisher","first-page":"11348","DOI":"10.1074\/jbc.M109.075184","volume":"285","author":"MA Herman","year":"2010","unstructured":"Herman MA, She P, Peroni OD et al (2010) Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem 285:11348\u201311356. https:\/\/doi.org\/10.1074\/jbc.M109.075184","journal-title":"J Biol Chem"},{"key":"2370_CR63","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/s41586-019-1503","volume":"572","author":"T Yoneshiro","year":"2019","unstructured":"Yoneshiro T, Wang Q, Tajima K (2019) BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature 572:614\u2013619. https:\/\/doi.org\/10.1038\/s41586-019-1503","journal-title":"Nature"},{"key":"2370_CR64","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3748\/wjg.14.193","volume":"14","author":"Y Wei","year":"2008","unstructured":"Wei Y, Rector RS, Thyfault JP et al (2008) Nonalcoholic fatty liver disease and mitochondrial dysfunction. World J Gastroenterol 14:193\u2013199. https:\/\/doi.org\/10.3748\/wjg.14.193","journal-title":"World J Gastroenterol"},{"key":"2370_CR65","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1111\/hepr.13346","volume":"49","author":"E Kakazu","year":"2019","unstructured":"Kakazu E, Sano A, Morosawa T (2019) Branched chain amino acids are associated with the heterogeneity of the area of lipid droplets in hepatocytes of patients with non-alcoholic fatty liver disease. Hepatol Res 49:860\u2013871. https:\/\/doi.org\/10.1111\/hepr.13346","journal-title":"Hepatol Res"},{"key":"2370_CR66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138889","author":"S Cheng","year":"2015","unstructured":"Cheng S, Wiklund P, Autio R et al (2015) Adipose tissue dysfunction and altered systemic amino acid metabolism are associated with non-alcoholic fatty liver disease. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0138889","journal-title":"PLoS ONE"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-020-02370-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-020-02370-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-020-02370-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T23:45:27Z","timestamp":1630107927000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-020-02370-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2370"],"URL":"https:\/\/doi.org\/10.1007\/s00394-020-02370-6","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"assertion":[{"value":"10 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The present study has been approved by the Research Ethics Committee of the University of Navarra on 24 April 2015 (ref. 54\/2015).and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"All participants of the present study gave their informed consent prior to their inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All data and materials support their published claims and comply with field standards.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}}]}}