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The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Concentrations of 134 metabolites of the Biocrates Absolute<jats:sup>IDQ<\/jats:sup> p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical trial registry<\/jats:title>\n                <jats:p>ClinicalTrials.gov Identifier: NCT03191110.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00394-021-02488-1","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T15:19:59Z","timestamp":1612538399000},"page":"3171-3184","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients"],"prefix":"10.1007","volume":"60","clinical-trial-number":[{"clinical-trial-number":"nct03191110","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Anne J. M. 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Ulrich (Director of the Comprehensive Cancer Center at Huntsman Cancer Institute, Salt Lake City, U.S.) oversees research funded by several pharmaceutical companies but has not received funding directly herself that could constitute a conflict to the current work. Where authors are identified as personnel of the International Agency for Research on Cancer \/ World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer \/ World Health Organization.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was performed in accordance with the Declaration of Helsinki. The COLON study was approved by the Committee of Research involving Human Subjects (region Arnhem-Nijmegen), the Netherlands. 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