{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:31:22Z","timestamp":1790645482158,"version":"4.1.0"},"reference-count":136,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s00394-021-02491-6","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T12:06:07Z","timestamp":1612353967000},"page":"3567-3584","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Can diet modulate trimethylamine N-oxide (TMAO) production? What do we know so far?"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2489-1237","authenticated-orcid":false,"given":"Karen Salve","family":"Coutinho-Wolino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8507-2369","authenticated-orcid":false,"given":"Ludmila F. M.","family":"de F. Cardozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-3204","authenticated-orcid":false,"given":"Viviane","family":"de Oliveira Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6752-6056","authenticated-orcid":false,"given":"Denise","family":"Mafra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-2033","authenticated-orcid":false,"given":"Milena Barcza","family":"Stockler-Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"2491_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102393","author":"E Rinninella","year":"2019","unstructured":"Rinninella E, Cintoni M, Raoul P et al (2019) Food components and dietary habits: keys for a healthy gut microbiota composition. Nutrients. https:\/\/doi.org\/10.3390\/nu11102393","journal-title":"Nutrients"},{"key":"2491_CR2","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1159\/000490615","volume":"64","author":"S Kim","year":"2018","unstructured":"Kim S, Jazwinski SM (2018) The gut microbiota and healthy aging. Gerontology 64:513\u2013520. https:\/\/doi.org\/10.1159\/000490615","journal-title":"Gerontology"},{"key":"2491_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nature23889","volume":"550","author":"J Lloyd-Price","year":"2017","unstructured":"Lloyd-Price J, Mahurkar A, Rahnavard G et al (2017) Strains, functions and dynamics in the expanded Human Microbiome Project. Nature 550:61\u201366. https:\/\/doi.org\/10.1038\/nature23889","journal-title":"Nature"},{"key":"2491_CR4","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/febs.15217","volume":"287","author":"P Illiano","year":"2020","unstructured":"Illiano P, Brambilla R, Parolini C (2020) The mutual interplay of gut microbiota, diet and human disease. FEBS J 287:833\u2013855. https:\/\/doi.org\/10.1111\/febs.15217","journal-title":"FEBS J"},{"key":"2491_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2180-11-7","volume":"11","author":"AW Walker","year":"2011","unstructured":"Walker AW, Sanderson JD, Churcher C et al (2011) High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease. BMC Microbiol 11:7. https:\/\/doi.org\/10.1186\/1471-2180-11-7","journal-title":"BMC Microbiol"},{"key":"2491_CR6","first-page":"560","volume":"9","author":"EMM Quigley","year":"2013","unstructured":"Quigley EMM (2013) Gut bacteria in health and disease. Gastroenterol Hepatol (N Y) 9:560\u2013569","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"2491_CR7","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1007\/s00018-017-2509-x","volume":"74","author":"GA Weiss","year":"2017","unstructured":"Weiss GA, Hennet T (2017) Mechanisms and consequences of intestinal dysbiosis. Cell Mol Life Sci 74:2959\u20132977. https:\/\/doi.org\/10.1007\/s00018-017-2509-x","journal-title":"Cell Mol Life Sci"},{"key":"2491_CR8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nri.2017.7","volume":"17","author":"M Levy","year":"2017","unstructured":"Levy M, Kolodziejczyk AA, Thaiss CA, Elinav E (2017) Dysbiosis and the immune system. Nat Rev Immunol 17:219\u2013232. https:\/\/doi.org\/10.1038\/nri.2017.7","journal-title":"Nat Rev Immunol"},{"key":"2491_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030496","author":"D Mafra","year":"2019","unstructured":"Mafra D, Borges N, Alvarenga L et al (2019) Dietary components that may influence the disturbed gut microbiota in chronic kidney disease. Nutrients. https:\/\/doi.org\/10.3390\/nu11030496","journal-title":"Nutrients"},{"key":"2491_CR10","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1159\/000492511","volume":"48","author":"FS Pimenta","year":"2018","unstructured":"Pimenta FS, Luaces-Regueira M, Ton AM et al (2018) Mechanisms of action of kefir in chronic cardiovascular and metabolic diseases. Cell Physiol Biochem 48:1901\u20131914. https:\/\/doi.org\/10.1159\/000492511","journal-title":"Cell Physiol Biochem"},{"key":"2491_CR11","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2147\/BTT.S19099","volume":"5","author":"S Prakash","year":"2011","unstructured":"Prakash S, Rodes L, Coussa-Charley M, Tomaro-Duchesneau C (2011) Gut microbiota: next frontier in understanding human health and development of biotherapeutics. Biologics 5:71\u201386. https:\/\/doi.org\/10.2147\/BTT.S19099","journal-title":"Biologics"},{"key":"2491_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4634172","author":"Y Liu","year":"2020","unstructured":"Liu Y, Dai M (2020) Trimethylamine N-oxide generated by the gut microbiota is associated with vascular inflammation: new insights into atherosclerosis. Mediators Inflamm. https:\/\/doi.org\/10.1155\/2020\/4634172","journal-title":"Mediators Inflamm"},{"key":"2491_CR13","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1111\/jcmm.14195","volume":"23","author":"M Jin","year":"2019","unstructured":"Jin M, Qian Z, Yin J et al (2019) The role of intestinal microbiota in cardiovascular disease. J Cell Mol Med 23:2343\u20132350. https:\/\/doi.org\/10.1111\/jcmm.14195","journal-title":"J Cell Mol Med"},{"key":"2491_CR14","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1177\/1535370219826526","volume":"244","author":"MA Bryniarski","year":"2019","unstructured":"Bryniarski MA, Hamarneh F, Yacoub R (2019) The role of chronic kidney disease-associated dysbiosis in cardiovascular disease. Exp Biol Med (Maywood) 244:514\u2013525. https:\/\/doi.org\/10.1177\/1535370219826526","journal-title":"Exp Biol Med (Maywood)"},{"key":"2491_CR15","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nm.3145","volume":"19","author":"RA Koeth","year":"2013","unstructured":"Koeth RA, Wang Z, Levison BS et al (2013) Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 19:576\u2013585. https:\/\/doi.org\/10.1038\/nm.3145","journal-title":"Nat Med"},{"key":"2491_CR16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature09922","volume":"472","author":"Z Wang","year":"2011","unstructured":"Wang Z, Klipfell E, Bennett BJ et al (2011) Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472:57\u201363. https:\/\/doi.org\/10.1038\/nature09922","journal-title":"Nature"},{"key":"2491_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082340","author":"N Arias","year":"2020","unstructured":"Arias N, Arboleya S, Allison J et al (2020) The relationship between choline bioavailability from diet, intestinal microbiota composition, and its modulation of human diseases. Nutrients. https:\/\/doi.org\/10.3390\/nu12082340","journal-title":"Nutrients"},{"key":"2491_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02966","author":"S Rath","year":"2020","unstructured":"Rath S, Rud T, Pieper DH, Vital M (2020) Potential TMA-producing bacteria are ubiquitously found in mammalia. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2019.02966","journal-title":"Front Microbiol"},{"key":"2491_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00409","author":"J Wang","year":"2019","unstructured":"Wang J, Gu X, Yang J et al (2019) Gut microbiota dysbiosis and increased plasma LPS and TMAO levels in patients with preeclampsia. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2019.00409","journal-title":"Front Cell Infect Microbiol"},{"key":"2491_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01387-y","author":"K-Y Xu","year":"2017","unstructured":"Xu K-Y, Xia G-H, Lu J-Q et al (2017) Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-017-01387-y","journal-title":"Sci Rep"},{"key":"2491_CR21","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00209-19","author":"A Ben\u00edtez-P\u00e1ez","year":"2019","unstructured":"Ben\u00edtez-P\u00e1ez A, Kj\u00f8lb\u00e6k L, G\u00f3mez Del Pulgar EM et al (2019) A multi-omics approach to unraveling the microbiome-mediated effects of arabinoxylan oligosaccharides in overweight humans. mSystems. https:\/\/doi.org\/10.1128\/mSystems.00209-19","journal-title":"mSystems"},{"key":"2491_CR22","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.trsl.2016.07.007","volume":"179","author":"WHW Tang","year":"2017","unstructured":"Tang WHW, Hazen SL (2017) Microbiome, trimethylamine N-oxide, and cardiometabolic disease. Transl Res 179:108\u2013115. https:\/\/doi.org\/10.1016\/j.trsl.2016.07.007","journal-title":"Transl Res"},{"key":"2491_CR23","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.2174\/1381612823666170622095324","volume":"23","author":"J Oellgaard","year":"2017","unstructured":"Oellgaard J, Winther SA, Hansen TS et al (2017) Trimethylamine N-oxide (TMAO) as a new potential therapeutic target for insulin resistance and cancer. Curr Pharm Des 23:3699\u20133712. https:\/\/doi.org\/10.2174\/1381612823666170622095324","journal-title":"Curr Pharm Des"},{"key":"2491_CR24","doi-asserted-by":"publisher","first-page":"e1900257","DOI":"10.1002\/mnfr.201900257","volume":"63","author":"X Tan","year":"2019","unstructured":"Tan X, Liu Y, Long J et al (2019) Trimethylamine N-oxide aggravates liver steatosis through modulation of bile acid metabolism and inhibition of farnesoid X receptor signaling in nonalcoholic fatty liver disease. Mol Nutr Food Res 63:e1900257. https:\/\/doi.org\/10.1002\/mnfr.201900257","journal-title":"Mol Nutr Food Res"},{"key":"2491_CR25","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s13195-018-0451-2","volume":"10","author":"NM Vogt","year":"2018","unstructured":"Vogt NM, Romano KA, Darst BF et al (2018) The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer\u2019s disease. Alzheimers Res Ther 10:124. https:\/\/doi.org\/10.1186\/s13195-018-0451-2","journal-title":"Alzheimers Res Ther"},{"key":"2491_CR26","doi-asserted-by":"publisher","first-page":"4204","DOI":"10.1172\/JCI72331","volume":"124","author":"WHW Tang","year":"2014","unstructured":"Tang WHW, Hazen SL (2014) The contributory role of gut microbiota in cardiovascular disease. J Clin Invest 124:4204\u20134211. https:\/\/doi.org\/10.1172\/JCI72331","journal-title":"J Clin Invest"},{"key":"2491_CR27","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1146\/annurev-med-060513-093205","volume":"66","author":"JM Brown","year":"2015","unstructured":"Brown JM, Hazen SL (2015) The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu Rev Med 66:343\u2013359. https:\/\/doi.org\/10.1146\/annurev-med-060513-093205","journal-title":"Annu Rev Med"},{"key":"2491_CR28","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1161\/CIRCRESAHA.116.305360","volume":"116","author":"WHW Tang","year":"2015","unstructured":"Tang WHW, Wang Z, Kennedy DJ et al (2015) Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res 116:448\u2013455. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.305360","journal-title":"Circ Res"},{"key":"2491_CR29","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/joim.12328","volume":"277","author":"M Tr\u00f8seid","year":"2015","unstructured":"Tr\u00f8seid M, Ueland T, Hov JR et al (2015) Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure. J Intern Med 277:717\u2013726. https:\/\/doi.org\/10.1111\/joim.12328","journal-title":"J Intern Med"},{"key":"2491_CR30","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1093\/advances\/nmz012","volume":"10","author":"NA Kalagi","year":"2019","unstructured":"Kalagi NA, Abbott KA, Alburikan KA et al (2019) Modulation of circulating trimethylamine N-oxide concentrations by dietary supplements and pharmacological agents: a systematic review. Adv Nutr 10:876\u2013887. https:\/\/doi.org\/10.1093\/advances\/nmz012","journal-title":"Adv Nutr"},{"key":"2491_CR31","doi-asserted-by":"publisher","first-page":"745","DOI":"10.2215\/CJN.00600207","volume":"2","author":"DS Goldfarb","year":"2007","unstructured":"Goldfarb DS, Modersitzki F, Asplin JR (2007) A randomized, controlled trial of lactic acid bacteria for idiopathic hyperoxaluria. Clin J Am Soc Nephrol 2:745\u2013749. https:\/\/doi.org\/10.2215\/CJN.00600207","journal-title":"Clin J Am Soc Nephrol"},{"key":"2491_CR32","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1146\/annurev-nutr-071816-064732","volume":"37","author":"SH Zeisel","year":"2017","unstructured":"Zeisel SH, Warrier M (2017) Trimethylamine N-oxide, the microbiome, and heart and kidney disease. Annu Rev Nutr 37:157\u2013181. https:\/\/doi.org\/10.1146\/annurev-nutr-071816-064732","journal-title":"Annu Rev Nutr"},{"key":"2491_CR33","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1089\/ars.2012.4581","volume":"18","author":"D Del Rio","year":"2013","unstructured":"Del Rio D, Rodriguez-Mateos A, Spencer JPE et al (2013) Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 18:1818\u20131892. https:\/\/doi.org\/10.1089\/ars.2012.4581","journal-title":"Antioxid Redox Signal"},{"key":"2491_CR34","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","volume":"368","author":"WHW Tang","year":"2013","unstructured":"Tang WHW, Wang Z, Levison BS et al (2013) Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 368:1575\u20131584. https:\/\/doi.org\/10.1056\/NEJMoa1109400","journal-title":"N Engl J Med"},{"key":"2491_CR35","doi-asserted-by":"publisher","first-page":"26745","DOI":"10.1038\/srep26745","volume":"6","author":"E Randrianarisoa","year":"2016","unstructured":"Randrianarisoa E, Lehn-Stefan A, Wang X et al (2016) Relationship of serum trimethylamine N-oxide (TMAO) levels with early atherosclerosis in humans. Sci Rep 6:26745. https:\/\/doi.org\/10.1038\/srep26745","journal-title":"Sci Rep"},{"key":"2491_CR36","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.biopha.2017.11.016","volume":"97","author":"J Geng","year":"2018","unstructured":"Geng J, Yang C, Wang B et al (2018) Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK\/JNK pathway. Biomed Pharmacother 97:941\u2013947. https:\/\/doi.org\/10.1016\/j.biopha.2017.11.016","journal-title":"Biomed Pharmacother"},{"key":"2491_CR37","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","volume":"165","author":"W Zhu","year":"2016","unstructured":"Zhu W, Gregory JC, Org E et al (2016) Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk. Cell 165:111\u2013124. https:\/\/doi.org\/10.1016\/j.cell.2016.02.011","journal-title":"Cell"},{"key":"2491_CR38","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002767","author":"MM Seldin","year":"2016","unstructured":"Seldin MM, Meng Y, Qi H et al (2016) Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-\u03baB. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.115.002767","journal-title":"J Am Heart Assoc"},{"key":"2491_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103228","author":"M Canyelles","year":"2018","unstructured":"Canyelles M, Tondo M, Ced\u00f3 L et al (2018) Trimethylamine N-oxide: a link among diet, gut microbiota, gene regulation of liver and intestine cholesterol homeostasis and HDL function. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms19103228","journal-title":"Int J Mol Sci"},{"key":"2491_CR40","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1194\/jlr.M069807","volume":"57","author":"H Liu","year":"2016","unstructured":"Liu H, Pathak P, Boehme S, Chiang JYL (2016) Cholesterol 7\u03b1-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis. J Lipid Res 57:1831\u20131844. https:\/\/doi.org\/10.1194\/jlr.M069807","journal-title":"J Lipid Res"},{"key":"2491_CR41","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1186\/s12944-018-0939-6","volume":"17","author":"L Ding","year":"2018","unstructured":"Ding L, Chang M, Guo Y et al (2018) Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism. Lipids Health Dis 17:286. https:\/\/doi.org\/10.1186\/s12944-018-0939-6","journal-title":"Lipids Health Dis"},{"key":"2491_CR42","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s10157-015-1207-y","volume":"20","author":"A Mafune","year":"2016","unstructured":"Mafune A, Iwamoto T, Tsutsumi Y et al (2016) Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study. Clin Exp Nephrol 20:731\u2013739. https:\/\/doi.org\/10.1007\/s10157-015-1207-y","journal-title":"Clin Exp Nephrol"},{"key":"2491_CR43","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002816","author":"V Senthong","year":"2016","unstructured":"Senthong V, Wang Z, Li XS et al (2016) Intestinal microbiota-generated metabolite trimethylamine-N-oxide and 5-year mortality risk in stable coronary artery disease: the contributory role of intestinal microbiota in a COURAGE-Like Patient Cohort. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.115.002816","journal-title":"J Am Heart Assoc"},{"key":"2491_CR44","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.cardfail.2014.11.006","volume":"21","author":"WHW Tang","year":"2015","unstructured":"Tang WHW, Wang Z, Shrestha K et al (2015) Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure. J Card Fail 21:91\u201396. https:\/\/doi.org\/10.1016\/j.cardfail.2014.11.006","journal-title":"J Card Fail"},{"key":"2491_CR45","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1093\/eurheartj\/ehu002","volume":"35","author":"Z Wang","year":"2014","unstructured":"Wang Z, Tang WHW, Buffa JA et al (2014) Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur Heart J 35:904\u2013910. https:\/\/doi.org\/10.1093\/eurheartj\/ehu002","journal-title":"Eur Heart J"},{"key":"2491_CR46","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1093\/eurheartj\/ehx342","volume":"38","author":"GG Schiattarella","year":"2017","unstructured":"Schiattarella GG, Sannino A, Toscano E et al (2017) Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis. Eur Heart J 38:2948\u20132956. https:\/\/doi.org\/10.1093\/eurheartj\/ehx342","journal-title":"Eur Heart J"},{"key":"2491_CR47","doi-asserted-by":"publisher","first-page":"110856","DOI":"10.1016\/j.nut.2020.110856","volume":"78","author":"MA Farhangi","year":"2020","unstructured":"Farhangi MA (2020) Gut microbiota-dependent trimethylamine N-oxide and all-cause mortality: Findings from an updated systematic review and meta-analysis. Nutrition 78:110856. https:\/\/doi.org\/10.1016\/j.nut.2020.110856","journal-title":"Nutrition"},{"key":"2491_CR48","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190515","author":"M Rexidamu","year":"2019","unstructured":"Rexidamu M, Li H, Jin H, Huang J (2019) Serum levels of Trimethylamine-N-oxide in patients with ischemic stroke. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20190515","journal-title":"Biosci Rep"},{"key":"2491_CR49","first-page":"827","volume":"17","author":"M Tong","year":"2009","unstructured":"Tong M, Neusner A, Longato L et al (2009) Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer\u2019s disease. J Alzheimers Dis 17:827\u2013844","journal-title":"J Alzheimers Dis"},{"key":"2491_CR50","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3945\/ajcn.117.157107","volume":"106","author":"Z Shan","year":"2017","unstructured":"Shan Z, Sun T, Huang H et al (2017) Association between microbiota-dependent metabolite trimethylamine-N-oxide and type 2 diabetes. Am J Clin Nutr 106:888\u2013894. https:\/\/doi.org\/10.3945\/ajcn.117.157107","journal-title":"Am J Clin Nutr"},{"key":"2491_CR51","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/ajcn\/nqy116","volume":"108","author":"P Li","year":"2018","unstructured":"Li P, Zhong C, Li S et al (2018) Plasma concentration of trimethylamine-N-oxide and risk of gestational diabetes mellitus. Am J Clin Nutr 108:603\u2013610. https:\/\/doi.org\/10.1093\/ajcn\/nqy116","journal-title":"Am J Clin Nutr"},{"key":"2491_CR52","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1111\/obr.12843","volume":"20","author":"R Zhuang","year":"2019","unstructured":"Zhuang R, Ge X, Han L et al (2019) Gut microbe\u2013generated metabolite trimethylamine N-oxide and the risk of diabetes: A systematic review and dose-response meta-analysis. Obes Rev 20:883\u2013894. https:\/\/doi.org\/10.1111\/obr.12843","journal-title":"Obes Rev"},{"key":"2491_CR53","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","volume":"389","author":"AC Webster","year":"2017","unstructured":"Webster AC, Nagler EV, Morton RL, Masson P (2017) Chronic kidney disease. Lancet 389:1238\u20131252. https:\/\/doi.org\/10.1016\/S0140-6736(16)32064-5","journal-title":"Lancet"},{"key":"2491_CR54","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1042\/CS20171107","volume":"132","author":"WL Lau","year":"2018","unstructured":"Lau WL, Savoj J, Nakata MB, Vaziri ND (2018) Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins. Clin Sci (Lond) 132:509\u2013522. https:\/\/doi.org\/10.1042\/CS20171107","journal-title":"Clin Sci (Lond)"},{"key":"2491_CR55","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.semnephrol.2018.01.008","volume":"38","author":"DY Li","year":"2018","unstructured":"Li DY, Wilson Tang WH (2018) Contributory role of gut microbiota and their metabolites towards cardiovascular complications in chronic kidney disease. Semin Nephrol 38:193\u2013205. https:\/\/doi.org\/10.1016\/j.semnephrol.2018.01.008","journal-title":"Semin Nephrol"},{"key":"2491_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197237","author":"C-N Hsu","year":"2020","unstructured":"Hsu C-N, Yang H-W, Hou C-Y et al (2020) Maternal adenine-induced chronic kidney disease programs hypertension in adult male rat offspring: implications of nitric oxide and gut microbiome derived metabolites. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21197237","journal-title":"Int J Mol Sci"},{"key":"2491_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11110635","author":"CC Pelletier","year":"2019","unstructured":"Pelletier CC, Croyal M, Ene L et al (2019) Elevation of trimethylamine-N-oxide in chronic kidney disease: contribution of decreased glomerular filtration rate. Toxins (Basel). https:\/\/doi.org\/10.3390\/toxins11110635","journal-title":"Toxins (Basel)"},{"key":"2491_CR58","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1681\/ASN.2012101006","volume":"24","author":"EP Rhee","year":"2013","unstructured":"Rhee EP, Clish CB, Ghorbani A et al (2013) A combined epidemiologic and metabolomic approach improves CKD prediction. J Am Soc Nephrol 24:1330\u20131338. https:\/\/doi.org\/10.1681\/ASN.2012101006","journal-title":"J Am Soc Nephrol"},{"key":"2491_CR59","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1681\/ASN.2014111063","volume":"27","author":"JR Stubbs","year":"2016","unstructured":"Stubbs JR, House JA, Ocque AJ et al (2016) Serum trimethylamine-N-oxide is elevated in CKD and correlates with coronary atherosclerosis burden. J Am Soc Nephrol 27:305\u2013313. https:\/\/doi.org\/10.1681\/ASN.2014111063","journal-title":"J Am Soc Nephrol"},{"key":"2491_CR60","doi-asserted-by":"publisher","first-page":"e12768","DOI":"10.1111\/acel.12768","volume":"17","author":"D Li","year":"2018","unstructured":"Li D, Ke Y, Zhan R et al (2018) Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice. Aging Cell 17:e12768. https:\/\/doi.org\/10.1111\/acel.12768","journal-title":"Aging Cell"},{"key":"2491_CR61","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature18846","volume":"535","author":"JL Sonnenburg","year":"2016","unstructured":"Sonnenburg JL, B\u00e4ckhed F (2016) Diet-microbiota interactions as moderators of human metabolism. Nature 535:56\u201364. https:\/\/doi.org\/10.1038\/nature18846","journal-title":"Nature"},{"key":"2491_CR62","doi-asserted-by":"publisher","first-page":"6ra14","DOI":"10.1126\/scitranslmed.3000322","volume":"1","author":"PJ Turnbaugh","year":"2009","unstructured":"Turnbaugh PJ, Ridaura VK, Faith JJ et al (2009) the effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic Mice. Science Translational Medicine 1:6ra14. https:\/\/doi.org\/10.1126\/scitranslmed.3000322","journal-title":"Science Translational Medicine"},{"key":"2491_CR63","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12944-017-0653-9","volume":"17","author":"J Chen","year":"2018","unstructured":"Chen J, Guo Y, Gui Y, Xu D (2018) Physical exercise, gut, gut microbiota, and atherosclerotic cardiovascular diseases. Lipids Health Dis 17:17. https:\/\/doi.org\/10.1186\/s12944-017-0653-9","journal-title":"Lipids Health Dis"},{"key":"2491_CR64","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.3389\/fmicb.2017.02146","volume":"8","author":"M Lyu","year":"2017","unstructured":"Lyu M, Wang Y-F, Fan G-W et al (2017) Balancing herbal medicine and functional food for prevention and treatment of cardiometabolic diseases through modulating gut microbiota. Front Microbiol 8:2146. https:\/\/doi.org\/10.3389\/fmicb.2017.02146","journal-title":"Front Microbiol"},{"key":"2491_CR65","doi-asserted-by":"publisher","first-page":"223S","DOI":"10.1093\/ajcn\/81.1.223S","volume":"81","author":"V Cheynier","year":"2005","unstructured":"Cheynier V (2005) Polyphenols in foods are more complex than often thought. Am J Clin Nutr 81:223S-229S. https:\/\/doi.org\/10.1093\/ajcn\/81.1.223S","journal-title":"Am J Clin Nutr"},{"key":"2491_CR66","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1039\/b802662a","volume":"26","author":"A Crozier","year":"2009","unstructured":"Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26:1001\u20131043. https:\/\/doi.org\/10.1039\/b802662a","journal-title":"Nat Prod Rep"},{"key":"2491_CR67","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1038\/s41598-017-02200-6","volume":"7","author":"SM Henning","year":"2017","unstructured":"Henning SM, Yang J, shao P et al (2017) Health benefit of vegetable\/fruit juice-based diet: Role of microbiome. Sci Rep 7:2167. https:\/\/doi.org\/10.1038\/s41598-017-02200-6","journal-title":"Sci Rep"},{"key":"2491_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030497","author":"E Caro-G\u00f3mez","year":"2019","unstructured":"Caro-G\u00f3mez E, Sierra JA, Escobar JS et al (2019) green coffee extract improves cardiometabolic parameters and modulates gut microbiota in high-fat-diet-fed ApoE-\/- mice. Nutrients. https:\/\/doi.org\/10.3390\/nu11030497","journal-title":"Nutrients"},{"key":"2491_CR69","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1099\/mic.0.042127-0","volume":"156","author":"RA Kemperman","year":"2010","unstructured":"Kemperman RA, Bolca S, Roger LC, Vaughan EE (2010) Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities. Microbiology (Reading, Engl) 156:3224\u20133231. https:\/\/doi.org\/10.1099\/mic.0.042127-0","journal-title":"Microbiology (Reading, Engl)"},{"key":"2491_CR70","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1099\/mic.0.2007\/007807-0","volume":"153","author":"PD Stapleton","year":"2007","unstructured":"Stapleton PD, Shah S, Ehlert K et al (2007) The beta-lactam-resistance modifier (-)-epicatechin gallate alters the architecture of the cell wall of Staphylococcus aureus. Microbiology (Reading, Engl) 153:2093\u20132103. https:\/\/doi.org\/10.1099\/mic.0.2007\/007807-0","journal-title":"Microbiology (Reading, Engl)"},{"key":"2491_CR71","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00248-004-0180-x","volume":"50","author":"AH Smith","year":"2005","unstructured":"Smith AH, Zoetendal E, Mackie RI (2005) Bacterial mechanisms to overcome inhibitory effects of dietary tannins. Microb Ecol 50:197\u2013205. https:\/\/doi.org\/10.1007\/s00248-004-0180-x","journal-title":"Microb Ecol"},{"key":"2491_CR72","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092322","author":"D Cianciosi","year":"2018","unstructured":"Cianciosi D, Forbes-Hern\u00e1ndez TY, Afrin S et al (2018) Phenolic compounds in honey and their associated health benefits: a review. Molecules. https:\/\/doi.org\/10.3390\/molecules23092322","journal-title":"Molecules"},{"key":"2491_CR73","doi-asserted-by":"publisher","first-page":"3128951","DOI":"10.1155\/2016\/3128951","volume":"2016","author":"JA Sirerol","year":"2016","unstructured":"Sirerol JA, Rodr\u00edguez ML, Mena S et al (2016) Role of natural stilbenes in the prevention of cancer. Oxid Med Cell Longev 2016:3128951. https:\/\/doi.org\/10.1155\/2016\/3128951","journal-title":"Oxid Med Cell Longev"},{"key":"2491_CR74","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.fitote.2015.07.009","volume":"105","author":"F Messina","year":"2015","unstructured":"Messina F, Guglielmini G, Curini M et al (2015) Effect of substituted stilbenes on platelet function. Fitoterapia 105:228\u2013233. https:\/\/doi.org\/10.1016\/j.fitote.2015.07.009","journal-title":"Fitoterapia"},{"key":"2491_CR75","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/biof.1363","volume":"43","author":"D Barreca","year":"2017","unstructured":"Barreca D, Gattuso G, Bellocco E et al (2017) Flavanones: Citrus phytochemical with health-promoting properties. BioFactors 43:495\u2013506. https:\/\/doi.org\/10.1002\/biof.1363","journal-title":"BioFactors"},{"key":"2491_CR76","doi-asserted-by":"publisher","first-page":"e02210","DOI":"10.1128\/mBio.02210-15","volume":"7","author":"M Chen","year":"2016","unstructured":"Chen M, Yi L, Zhang Y et al (2016) Resveratrol attenuates trimethylamine-N-Oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota. mBio 7:e02210-02215. https:\/\/doi.org\/10.1128\/mBio.02210-15","journal-title":"mBio"},{"key":"2491_CR77","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010139","author":"G Annunziata","year":"2019","unstructured":"Annunziata G, Maisto M, Schisano C et al (2019) Effects of grape pomace polyphenolic extract (Taurisolo\u00ae) in reducing TMAO serum levels in humans: preliminary results from a randomized, placebo-controlled. Cross-Over Study Nutr. https:\/\/doi.org\/10.3390\/nu11010139","journal-title":"Cross-Over Study Nutr"},{"key":"2491_CR78","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3389\/fphar.2019.00575","volume":"10","author":"G Annunziata","year":"2019","unstructured":"Annunziata G, Maisto M, Schisano C et al (2019) Effect of grape pomace polyphenols with or without pectin on TMAO Serum levels assessed by LC\/MS-based assay: a preliminary clinical study on overweight\/obese subjects. Front Pharmacol 10:575. https:\/\/doi.org\/10.3389\/fphar.2019.00575","journal-title":"Front Pharmacol"},{"key":"2491_CR79","doi-asserted-by":"publisher","first-page":"6470","DOI":"10.1039\/c8fo01778f","volume":"9","author":"L Bresciani","year":"2018","unstructured":"Bresciani L, Dall\u2019Asta M, Favari C et al (2018) An in vitro exploratory study of dietary strategies based on polyphenol-rich beverages, fruit juices and oils to control trimethylamine production in the colon. Food Funct 9:6470\u20136483. https:\/\/doi.org\/10.1039\/c8fo01778f","journal-title":"Food Funct"},{"key":"2491_CR80","doi-asserted-by":"publisher","first-page":"e1900073","DOI":"10.1002\/mnfr.201900073","volume":"63","author":"C-N Hsu","year":"2019","unstructured":"Hsu C-N, Chang-Chien G-P, Lin S et al (2019) Targeting on gut microbial metabolite trimethylamine-N-oxide and short-chain fatty acid to prevent maternal high-fructose-diet-induced developmental programming of hypertension in adult male offspring. Mol Nutr Food Res 63:e1900073. https:\/\/doi.org\/10.1002\/mnfr.201900073","journal-title":"Mol Nutr Food Res"},{"key":"2491_CR81","doi-asserted-by":"publisher","first-page":"7174","DOI":"10.1039\/c9fo01465a","volume":"10","author":"Q Li","year":"2019","unstructured":"Li Q, Chen H, Zhang M et al (2019) Altered short chain fatty acid profiles induced by dietary fiber intervention regulate AMPK levels and intestinal homeostasis. Food Funct 10:7174\u20137187. https:\/\/doi.org\/10.1039\/c9fo01465a","journal-title":"Food Funct"},{"key":"2491_CR82","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112678","author":"D Angelino","year":"2019","unstructured":"Angelino D, Carregosa D, Domenech-Coca C et al (2019) 5-(Hydroxyphenyl)-\u03b3-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain: evidence from different in silico, in vitro and in vivo experimental models. Nutrients. https:\/\/doi.org\/10.3390\/nu11112678","journal-title":"Nutrients"},{"key":"2491_CR83","doi-asserted-by":"publisher","first-page":"124898","DOI":"10.1016\/j.foodchem.2019.05.172","volume":"297","author":"A Sinopoli","year":"2019","unstructured":"Sinopoli A, Calogero G, Bartolotta A (2019) Computational aspects of anthocyanidins and anthocyanins: a review. Food Chem 297:124898. https:\/\/doi.org\/10.1016\/j.foodchem.2019.05.172","journal-title":"Food Chem"},{"key":"2491_CR84","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.foodres.2018.02.016","volume":"107","author":"S Liu","year":"2018","unstructured":"Liu S, You L, Zhao Y, Chang X (2018) Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo. Food Res Int 107:73\u201383. https:\/\/doi.org\/10.1016\/j.foodres.2018.02.016","journal-title":"Food Res Int"},{"key":"2491_CR85","doi-asserted-by":"publisher","first-page":"7869","DOI":"10.1021\/acs.jafc.9b03092","volume":"67","author":"P-Y Chen","year":"2019","unstructured":"Chen P-Y, Li S, Koh Y-C et al (2019) Oolong tea extract and citrus peel polymethoxyflavones reduce transformation of l-carnitine to trimethylamine-N-oxide and decrease vascular inflammation in l-carnitine feeding mice. J Agric Food Chem 67:7869\u20137879. https:\/\/doi.org\/10.1021\/acs.jafc.9b03092","journal-title":"J Agric Food Chem"},{"key":"2491_CR86","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010122","author":"GC Tenore","year":"2019","unstructured":"Tenore GC, Caruso D, Buonomo G et al (2019) Lactofermented annurca apple puree as a functional food indicated for the control of plasma lipid and oxidative amine levels: results from a randomised clinical trial. Nutrients. https:\/\/doi.org\/10.3390\/nu11010122","journal-title":"Nutrients"},{"key":"2491_CR87","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082448","author":"T Lim","year":"2020","unstructured":"Lim T, Ryu J, Lee K et al (2020) Protective effects of black raspberry (Rubus occidentalis) extract against hypercholesterolemia and hepatic inflammation in rats fed high-fat and high-choline diets. Nutrients. https:\/\/doi.org\/10.3390\/nu12082448","journal-title":"Nutrients"},{"key":"2491_CR88","doi-asserted-by":"publisher","first-page":"5350","DOI":"10.1039\/c8fo00962g","volume":"9","author":"CJ Angiletta","year":"2018","unstructured":"Angiletta CJ, Griffin LE, Steele CN et al (2018) Impact of short-term flavanol supplementation on fasting plasma trimethylamine N-oxide concentrations in obese adults. Food Funct 9:5350\u20135361. https:\/\/doi.org\/10.1039\/c8fo00962g","journal-title":"Food Funct"},{"key":"2491_CR89","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.2174\/1389201020666181217142051","volume":"19","author":"E Bia\u0142ecka-Florja\u0144czyk","year":"2018","unstructured":"Bia\u0142ecka-Florja\u0144czyk E, Fabiszewska A, Zieniuk B (2018) Phenolic acids derivatives\u2014biotechnological methods of synthesis and bioactivity. Curr Pharm Biotechnol 19:1098\u20131113. https:\/\/doi.org\/10.2174\/1389201020666181217142051","journal-title":"Curr Pharm Biotechnol"},{"key":"2491_CR90","doi-asserted-by":"publisher","first-page":"e00370","DOI":"10.1016\/j.btre.2019.e00370","volume":"24","author":"N Kumar","year":"2019","unstructured":"Kumar N, Goel N (2019) Phenolic acids: natural versatile molecules with promising therapeutic applications. Biotechnol Rep (Amst) 24:e00370. https:\/\/doi.org\/10.1016\/j.btre.2019.e00370","journal-title":"Biotechnol Rep (Amst)"},{"key":"2491_CR91","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.fitote.2015.12.013","volume":"109","author":"Dall\u2019Acqua S, Stocchero M, Boschier","year":"2016","unstructured":"Dall\u2019Acqua S, Stocchero M, Boschiero I, et al (2016) New findings on the in vivo antioxidant activity of Curcuma longa extract by an integrated (1)H NMR and HPLC-MS metabolomic approach. Fitoterapia 109:125\u2013131. https:\/\/doi.org\/10.1016\/j.fitote.2015.12.013","journal-title":"Fitoterapia"},{"key":"2491_CR92","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010062","author":"A Dalla Via","year":"2019","unstructured":"Dalla Via A, Gargari G, Taverniti V et al (2019) Urinary TMAO levels are associated with the taxonomic composition of the gut microbiota and with the choline TMA-lyase gene (cutC) harbored by Enterobacteriaceae. Nutrients. https:\/\/doi.org\/10.3390\/nu12010062","journal-title":"Nutrients"},{"key":"2491_CR93","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1111\/bcp.13728","volume":"84","author":"G Latkovskis","year":"2018","unstructured":"Latkovskis G, Makarova E, Mazule M et al (2018) Loop diuretics decrease the renal elimination rate and increase the plasma levels of trimethylamine-N-oxide. Br J Clin Pharmacol 84:2634\u20132644. https:\/\/doi.org\/10.1111\/bcp.13728","journal-title":"Br J Clin Pharmacol"},{"key":"2491_CR94","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.jff.2015.04.001","volume":"15","author":"W-K Wu","year":"2015","unstructured":"Wu W-K, Panyod S, Ho C-T et al (2015) Dietary allicin reduces transformation of L-carnitine to TMAO through impact on gut microbiota. J Funct Foods 15:408\u2013417. https:\/\/doi.org\/10.1016\/j.jff.2015.04.001","journal-title":"J Funct Foods"},{"key":"2491_CR95","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jsbmb.2016.11.001","volume":"175","author":"M Kanhere","year":"2018","unstructured":"Kanhere M, Chassaing B, Gewirtz AT, Tangpricha V (2018) Role of vitamin D on gut microbiota in cystic fibrosis. J Steroid Biochem Mol Biol 175:82\u201387. https:\/\/doi.org\/10.1016\/j.jsbmb.2016.11.001","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2491_CR96","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600358","author":"R Obeid","year":"2017","unstructured":"Obeid R, Awwad HM, Kirsch SH et al (2017) Plasma trimethylamine-N-oxide following supplementation with vitamin D or D plus B vitamins. Mol Nutr Food Res. https:\/\/doi.org\/10.1002\/mnfr.201600358","journal-title":"Mol Nutr Food Res"},{"key":"2491_CR97","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/nu12051310","volume":"12","author":"LS Bislev","year":"2020","unstructured":"Bislev LS, Sundekilde UK, Kilic E et al (2020) Circulating levels of muscle-related metabolites increase in response to a daily moderately high dose of a vitamin D3 supplement in women with vitamin D insufficiency\u2014secondary analysis of a randomized placebo-controlled trial. Nutrients 12:1310. https:\/\/doi.org\/10.3390\/nu12051310","journal-title":"Nutrients"},{"key":"2491_CR98","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061310","author":"L Barrea","year":"2019","unstructured":"Barrea L, Muscogiuri G, Annunziata G et al (2019) A new light on vitamin D in obesity: a novel association with trimethylamine-N-oxide (TMAO). Nutrients. https:\/\/doi.org\/10.3390\/nu11061310","journal-title":"Nutrients"},{"key":"2491_CR99","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071675","author":"C Missailidis","year":"2019","unstructured":"Missailidis C, S\u00f8rensen N, Ashenafi S et al (2019) Vitamin D and phenylbutyrate supplementation does not modulate gut derived immune activation in HIV-1. Nutrients. https:\/\/doi.org\/10.3390\/nu11071675","journal-title":"Nutrients"},{"key":"2491_CR100","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092553","author":"LSA Augustin","year":"2020","unstructured":"Augustin LSA, Aas A-M, Astrup A et al (2020) dietary fibre consensus from the international carbohydrate quality consortium (ICQC). Nutrients. https:\/\/doi.org\/10.3390\/nu12092553","journal-title":"Nutrients"},{"key":"2491_CR101","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201700473","author":"Q Li","year":"2017","unstructured":"Li Q, Wu T, Liu R et al (2017) Soluble dietary fiber reduces trimethylamine metabolism via gut microbiota and co-regulates host AMPK pathways. Mol Nutr Food Res. https:\/\/doi.org\/10.1002\/mnfr.201700473","journal-title":"Mol Nutr Food Res"},{"key":"2491_CR102","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.3389\/fmicb.2017.01750","volume":"8","author":"W Cheng","year":"2017","unstructured":"Cheng W, Lu J, Li B et al (2017) Effect of functional oligosaccharides and ordinary dietary fiber on intestinal microbiota diversity. Front Microbiol 8:1750. https:\/\/doi.org\/10.3389\/fmicb.2017.01750","journal-title":"Front Microbiol"},{"key":"2491_CR103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196511","author":"W-C Liu","year":"2018","unstructured":"Liu W-C, Yang M-C, Wu Y-Y et al (2018) Lactobacillus plantarum reverse diabetes-induced Fmo3 and ICAM expression in mice through enteric dysbiosis-related c-Jun NH2-terminal kinase pathways. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0196511","journal-title":"PLoS ONE"},{"key":"2491_CR104","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1053\/j.jrn.2019.06.012","volume":"30","author":"E Hill","year":"2020","unstructured":"Hill E, Sapa H, Negrea L et al (2020) Effect of oat \u03b2-glucan supplementation on chronic kidney disease: a feasibility study. J Renal Nutr 30:208\u2013215. https:\/\/doi.org\/10.1053\/j.jrn.2019.06.012","journal-title":"J Renal Nutr"},{"key":"2491_CR105","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060793","author":"ME Baugh","year":"2018","unstructured":"Baugh ME, Steele CN, Angiletta CJ et al (2018) Inulin supplementation does not reduce plasma trimethylamine N-Oxide concentrations in individuals at risk for type 2 diabetes. Nutrients. https:\/\/doi.org\/10.3390\/nu10060793","journal-title":"Nutrients"},{"key":"2491_CR106","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.bpg.2015.12.001","volume":"30","author":"G Reid","year":"2016","unstructured":"Reid G (2016) Probiotics: definition, scope and mechanisms of action. Best Pract Res Clin Gastroenterol 30:17\u201325. https:\/\/doi.org\/10.1016\/j.bpg.2015.12.001","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2491_CR107","doi-asserted-by":"publisher","first-page":"4705","DOI":"10.1007\/s00253-020-10599-8","volume":"104","author":"K Fadhlaoui","year":"2020","unstructured":"Fadhlaoui K, Arnal M-E, Martineau M et al (2020) Archaea, specific genetic traits, and development of improved bacterial live biotherapeutic products: another face of next-generation probiotics. Appl Microbiol Biotechnol 104:4705\u20134716. https:\/\/doi.org\/10.1007\/s00253-020-10599-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"2491_CR108","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/1440-1681.13250","volume":"47","author":"J Moludi","year":"2020","unstructured":"Moludi J, Maleki V, Jafari-Vayghyan H et al (2020) Metabolic endotoxemia and cardiovascular disease: a systematic review about potential roles of prebiotics and probiotics. Clin Exp Pharmacol Physiol 47:927\u2013939. https:\/\/doi.org\/10.1111\/1440-1681.13250","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2491_CR109","doi-asserted-by":"publisher","first-page":"4299","DOI":"10.1039\/c8fo00349a","volume":"9","author":"L Qiu","year":"2018","unstructured":"Qiu L, Tao X, Xiong H et al (2018) Lactobacillus plantarum ZDY04 exhibits a strain-specific property of lowering TMAO via the modulation of gut microbiota in mice. Food Funct 9:4299\u20134309. https:\/\/doi.org\/10.1039\/c8fo00349a","journal-title":"Food Funct"},{"key":"2491_CR110","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.4014\/jmb.1703.03039","volume":"27","author":"L Qiu","year":"2017","unstructured":"Qiu L, Yang D, Tao X et al (2017) Enterobacter aerogenes ZDY01 attenuates choline-induced trimethylamine N-oxide levels by remodeling gut microbiota in mice. J Microbiol Biotechnol 27:1491\u20131499. https:\/\/doi.org\/10.4014\/jmb.1703.03039","journal-title":"J Microbiol Biotechnol"},{"key":"2491_CR111","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122908","author":"C-N Hsu","year":"2019","unstructured":"Hsu C-N, Hou C-Y, Chan JYH et al (2019) Hypertension programmed by perinatal high-fat diet: effect of maternal gut microbiota-targeted therapy. Nutrients. https:\/\/doi.org\/10.3390\/nu11122908","journal-title":"Nutrients"},{"key":"2491_CR112","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1161\/CIRCRESAHA.118.313565","volume":"123","author":"M Malik","year":"2018","unstructured":"Malik M, Suboc TM, Tyagi S et al (2018) Lactobacillus plantarum 299v supplementation improves vascular endothelial function and reduces inflammatory biomarkers in men with stable coronary artery disease. Circ Res 123:1091\u20131102. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313565","journal-title":"Circ Res"},{"key":"2491_CR113","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1007\/s12602-018-9411-1","volume":"11","author":"NA Borges","year":"2019","unstructured":"Borges NA, Stenvinkel P, Bergman P et al (2019) Effects of probiotic supplementation on trimethylamine-N-oxide plasma levels in hemodialysis patients: a pilot study. Probiotics Antimicrob Proteins 11:648\u2013654. https:\/\/doi.org\/10.1007\/s12602-018-9411-1","journal-title":"Probiotics Antimicrob Proteins"},{"key":"2491_CR114","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.atherosclerosis.2015.05.005","volume":"242","author":"NJ Tripolt","year":"2015","unstructured":"Tripolt NJ, Leber B, Triebl A et al (2015) Effect of Lactobacillus casei Shirota supplementation on trimethylamine-N-oxide levels in patients with metabolic syndrome: an open-label, randomized study. Atherosclerosis 242:141\u2013144. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2015.05.005","journal-title":"Atherosclerosis"},{"key":"2491_CR115","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1002\/oby.21212","volume":"23","author":"NE Boutagy","year":"2015","unstructured":"Boutagy NE, Neilson AP, Osterberg KL et al (2015) Probiotic supplementation and trimethylamine-N-oxide production following a high-fat diet. Obesity (Silver Spring) 23:2357\u20132363. https:\/\/doi.org\/10.1002\/oby.21212","journal-title":"Obesity (Silver Spring)"},{"key":"2491_CR116","doi-asserted-by":"publisher","first-page":"628","DOI":"10.18632\/aging.102645","volume":"12","author":"Q-J Wang","year":"2020","unstructured":"Wang Q-J, Shen Y-E, Wang X et al (2020) Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP\/PS1 mice. Aging 12:628\u2013649. https:\/\/doi.org\/10.18632\/aging.102645","journal-title":"Aging"},{"key":"2491_CR117","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-020-02278-1","author":"S Chen","year":"2020","unstructured":"Chen S, Jiang P, Yu D et al (2020) Effects of probiotic supplementation on serum trimethylamine-N-oxide level and gut microbiota composition in young males: a double-blinded randomized controlled trial. Eur J Nutr. https:\/\/doi.org\/10.1007\/s00394-020-02278-1","journal-title":"Eur J Nutr"},{"key":"2491_CR118","doi-asserted-by":"publisher","first-page":"105908","DOI":"10.1016\/j.ijantimicag.2020.105908","volume":"55","author":"C Montrucchio","year":"2020","unstructured":"Montrucchio C, De Nicol\u00f2 A, D\u2019Ettorre G et al (2020) Serum trimethylamine-N-oxide concentrations in people living with HIV and the effect of probiotic supplementation. Int J Antimicrob Agents 55:105908. https:\/\/doi.org\/10.1016\/j.ijantimicag.2020.105908","journal-title":"Int J Antimicrob Agents"},{"key":"2491_CR119","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/msb4100190","volume":"4","author":"F-PJ Martin","year":"2008","unstructured":"Martin F-PJ, Wang Y, Sprenger N et al (2008) Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol Syst Biol 4:157. https:\/\/doi.org\/10.1038\/msb4100190","journal-title":"Mol Syst Biol"},{"key":"2491_CR120","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00139","author":"K Chen","year":"2017","unstructured":"Chen K, Zheng X, Feng M et al (2017) Gut microbiota-dependent metabolite trimethylamine N-oxide contributes to cardiac dysfunction in western diet-induced obese mice. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2017.00139","journal-title":"Front Physiol"},{"key":"2491_CR121","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1136\/gutjnl-2018-317609","volume":"68","author":"Y Wan","year":"2019","unstructured":"Wan Y, Wang F, Yuan J et al (2019) Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial. Gut 68:1417\u20131429. https:\/\/doi.org\/10.1136\/gutjnl-2018-317609","journal-title":"Gut"},{"key":"2491_CR122","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1292\/jvms.19-0055","volume":"81","author":"A Mori","year":"2019","unstructured":"Mori A, Goto A, Kibe R et al (2019) Comparison of the effects of four commercially available prescription diet regimens on the fecal microbiome in healthy dogs. J Vet Med Sci 81:1783\u20131790. https:\/\/doi.org\/10.1292\/jvms.19-0055","journal-title":"J Vet Med Sci"},{"key":"2491_CR123","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.nutres.2015.07.002","volume":"35","author":"NE Boutagy","year":"2015","unstructured":"Boutagy NE, Neilson AP, Osterberg KL et al (2015) Short-term high-fat diet increases postprandial trimethylamine-N-oxide in humans. Nutr Res 35:858\u2013864. https:\/\/doi.org\/10.1016\/j.nutres.2015.07.002","journal-title":"Nutr Res"},{"key":"2491_CR124","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-02036-y","author":"A Genoni","year":"2019","unstructured":"Genoni A, Christophersen CT, Lo J et al (2019) Long-term Paleolithic diet is associated with lower resistant starch intake, different gut microbiota composition and increased serum TMAO concentrations. Eur J Nutr. https:\/\/doi.org\/10.1007\/s00394-019-02036-y","journal-title":"Eur J Nutr"},{"key":"2491_CR125","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1017\/S0007114516004165","volume":"116","author":"N Bergeron","year":"2016","unstructured":"Bergeron N, Williams PT, Lamendella R et al (2016) Diets high in resistant starch increase plasma levels of trimethylamine-N-oxide, a gut microbiome metabolite associated with CVD risk. Br J Nutr 116:2020\u20132029. https:\/\/doi.org\/10.1017\/S0007114516004165","journal-title":"Br J Nutr"},{"key":"2491_CR126","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1039\/c9fo00333a","volume":"10","author":"LE Griffin","year":"2019","unstructured":"Griffin LE, Djuric Z, Angiletta CJ et al (2019) A Mediterranean diet does not alter plasma trimethylamine N-oxide concentrations in healthy adults at risk for colon cancer. Food Funct 10:2138\u20132147. https:\/\/doi.org\/10.1039\/c9fo00333a","journal-title":"Food Funct"},{"key":"2491_CR127","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1002\/oby.22271","volume":"26","author":"MJ Leal-Witt","year":"2018","unstructured":"Leal-Witt MJ, Llobet M, Samino S et al (2018) Lifestyle intervention decreases urine trimethylamine N-oxide levels in prepubertal children with obesity. Obesity (Silver Spring) 26:1603\u20131610. https:\/\/doi.org\/10.1002\/oby.22271","journal-title":"Obesity (Silver Spring)"},{"key":"2491_CR128","doi-asserted-by":"publisher","first-page":"6675","DOI":"10.1039\/C9FO01853K","volume":"10","author":"F Wang","year":"2019","unstructured":"Wang F, Xu J, Jakovli\u0107 I et al (2019) Dietary betaine reduces liver lipid accumulation via improvement of bile acid and trimethylamine-N-oxide metabolism in blunt-snout bream. Food Funct 10:6675\u20136689. https:\/\/doi.org\/10.1039\/C9FO01853K","journal-title":"Food Funct"},{"key":"2491_CR129","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.numecd.2019.02.003","volume":"29","author":"JE Park","year":"2019","unstructured":"Park JE, Miller M, Rhyne J et al (2019) Differential effect of short-term popular diets on TMAO and other cardio-metabolic risk markers. Nutr Metab Cardiovasc Dis 29:513\u2013517. https:\/\/doi.org\/10.1016\/j.numecd.2019.02.003","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2491_CR130","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10020057","author":"R Th\u00f8gersen","year":"2020","unstructured":"Th\u00f8gersen R, Rasmussen MK, Sundekilde UK et al (2020) Background diet influences TMAO concentrations associated with red meat intake without influencing apparent hepatic TMAO-related activity in a porcine model. Metabolites. https:\/\/doi.org\/10.3390\/metabo10020057","journal-title":"Metabolites"},{"key":"2491_CR131","doi-asserted-by":"publisher","DOI":"10.3390\/nu11010179","author":"ML Erickson","year":"2019","unstructured":"Erickson ML, Malin SK, Wang Z et al (2019) Effects of lifestyle intervention on plasma trimethylamine N-oxide in obese adults. Nutrients. https:\/\/doi.org\/10.3390\/nu11010179","journal-title":"Nutrients"},{"key":"2491_CR132","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092207","author":"SM Mitchell","year":"2019","unstructured":"Mitchell SM, Milan AM, Mitchell CJ et al (2019) Protein intake at twice the RDA in older men increases circulatory concentrations of the microbiome metabolite trimethylamine-N-oxide (TMAO). Nutrients. https:\/\/doi.org\/10.3390\/nu11092207","journal-title":"Nutrients"},{"key":"2491_CR133","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1093\/ajcn\/nqaa203","volume":"112","author":"A Crimarco","year":"2020","unstructured":"Crimarco A, Springfield S, Petlura C et al (2020) A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood\u2014Meat Eating Alternative Trial (SWAP-MEAT). Am J Clin Nutr 112:1188\u20131199. https:\/\/doi.org\/10.1093\/ajcn\/nqaa203","journal-title":"Am J Clin Nutr"},{"key":"2491_CR134","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1080\/07315724.2017.1365026","volume":"37","author":"A Missimer","year":"2018","unstructured":"Missimer A, Fernandez ML, DiMarco DM et al (2018) Compared to an oatmeal breakfast, two eggs\/day increased plasma carotenoids and choline without increasing trimethyl amine N-oxide concentrations. J Am Coll Nutr 37:140\u2013148. https:\/\/doi.org\/10.1080\/07315724.2017.1365026","journal-title":"J Am Coll Nutr"},{"key":"2491_CR135","doi-asserted-by":"publisher","first-page":"108774","DOI":"10.1016\/j.foodres.2019.108774","volume":"128","author":"T Wu","year":"2020","unstructured":"Wu T, Gao Y, Hao J et al (2020) Capsanthin extract prevents obesity, reduces serum TMAO levels and modulates the gut microbiota composition in high-fat-diet induced obese C57BL\/6J mice. Food Res Int 128:108774. https:\/\/doi.org\/10.1016\/j.foodres.2019.108774","journal-title":"Food Res Int"},{"key":"2491_CR136","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031047","author":"L Bordoni","year":"2020","unstructured":"Bordoni L, Sawicka AK, Szarmach A et al (2020) A Pilot Study on the effects of l-carnitine and trimethylamine-N-oxide on platelet mitochondrial DNA methylation and CVD biomarkers in aged women. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21031047","journal-title":"Int J Mol Sci"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-021-02491-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-021-02491-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-021-02491-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T15:03:36Z","timestamp":1631545416000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-021-02491-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,3]]},"references-count":136,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["2491"],"URL":"https:\/\/doi.org\/10.1007\/s00394-021-02491-6","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,3]]},"assertion":[{"value":"24 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}