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The generalisability of these reports is limited by their design and scale. This study aimed to assess whether vitamin D supplementation improved IBS symptoms in a UK community setting.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a randomised, double-blind, placebo-controlled study. Participants were recruited from the community in winter months between December 2017 and March 2019. 135 participants received either vitamin D (3,000\u00a0IU <jats:italic>p.d<\/jats:italic>.) or placebo for 12\u00a0weeks. The primary outcome measure was change in IBS symptom severity; secondary outcomes included change in IBS-related quality of life.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The participants were analysed on an intent-to-treat basis. 60% of participants were vitamin D deficient or insufficient at baseline. Although vitamin D levels increased in the intervention arm relative to placebo (45.1\u2009\u00b1\u200932.88\u00a0nmol\/L <jats:italic>vs<\/jats:italic> 3.1\u2009\u00b1\u200926.15\u00a0nmol\/L; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was no difference in the change of IBS symptom severity between the active and placebo trial arms (\u2212\u00a062.5\u2009\u00b1\u200991.57 <jats:italic>vs<\/jats:italic> \u2013 75.2\u2009\u00b1\u200984.35, <jats:italic>p<\/jats:italic>\u2009=\u20090.426) over time. Similarly there was no difference between trial arms in \u03c4he change in quality of life (\u2212\u00a07.7\u2009\u00b1\u200925.36 <jats:italic>vs<\/jats:italic> \u2013 11.31\u2009\u00b1\u200925.02, <jats:italic>p<\/jats:italic>\u2009=\u20090.427).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>There is no case for advocating use of vitamin D in the management of IBS symptoms. The prevalence of vitamin D insufficiency suggests routine screening and supplementation should be implemented in this population for general health reasons.<\/jats:p>\n                <jats:p>This trial was retrospectively registered with ISRCTN (ISRCTN13277340) on 24th April 2018 after recruiting had been initiated.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00394-021-02633-w","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T11:02:55Z","timestamp":1627642975000},"page":"299-308","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-9853","authenticated-orcid":false,"given":"Claire E.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-7549","authenticated-orcid":false,"given":"Elizabeth A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-2228","authenticated-orcid":false,"given":"Bernard M.","family":"Corfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"2633_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2147\/clep.s40245","volume":"6","author":"C Canavan","year":"2014","unstructured":"Canavan C, West J, Card T (2014) The epidemiology of irritable bowel syndrome. 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