{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:09:34Z","timestamp":1780556974387,"version":"3.54.1"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["974159"],"award-info":[{"award-number":["974159"]}]},{"name":"Australian National Health and Medical Research Council","award":["991407"],"award-info":[{"award-number":["991407"]}]},{"name":"Australian National Health and Medical Research Council","award":["211069"],"award-info":[{"award-number":["211069"]}]},{"name":"Australian National Health and Medical Research Council","award":["262120"],"award-info":[{"award-number":["262120"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00394-021-02784-w","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:05:01Z","timestamp":1642982701000},"page":"1957-1964","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Associations between intake of dietary flavonoids and the 10-year incidence of tinnitus in older adults"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2007-9054","authenticated-orcid":false,"given":"Diana","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua R.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola P.","family":"Bondonno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine P.","family":"Bondonno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McAlpine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Burlutsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giriraj S.","family":"Shekhawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bamini","family":"Gopinath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"2784_CR1","volume-title":"The epidemiology of tinnitus","author":"D Adrian","year":"2000","unstructured":"Adrian D, Refaie A (2000) The epidemiology of tinnitus. Singular"},{"key":"2784_CR2","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1055\/s-0040-1715975","volume":"13","author":"DM Nondahl","year":"2002","unstructured":"Nondahl DM, Cruickshanks KJ, Wiley TL et al (2002) Prevalence and 5-year incidence of tinnitus among older adults: the epidemiology of hearing loss study. J Am Acad Audiol 13:323\u2013331","journal-title":"J Am Acad Audiol"},{"key":"2784_CR3","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1177\/0194599814545325","volume":"151","author":"DE Tunkel","year":"2014","unstructured":"Tunkel DE, Bauer CA, Sun GH et al (2014) Clinical practice guideline: tinnitus. Otolaryngol Head Neck Surg 151:S1\u2013S40","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2784_CR4","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/AUD.0b013e3181cdb2a2","volume":"31","author":"B Gopinath","year":"2010","unstructured":"Gopinath B, McMahon CM, Rochtchina E et al (2010) Incidence, persistence, and progression of tinnitus symptoms in older adults: the blue mountains hearing study. Ear Hear 31:407\u2013412. https:\/\/doi.org\/10.1097\/AUD.0b013e3181cdb2a2","journal-title":"Ear Hear"},{"key":"2784_CR5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.31128\/AJGP-12-17-4420","volume":"47","author":"AA Esmaili","year":"2018","unstructured":"Esmaili AA, Renton J (2018) A review of tinnitus. Aust J Gen Pract 47:205\u2013208","journal-title":"Aust J Gen Pract"},{"key":"2784_CR6","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.amjmed.2010.02.015","volume":"123","author":"J Shargorodsky","year":"2010","unstructured":"Shargorodsky J, Curhan GC, Farwell WR (2010) Prevalence and characteristics of tinnitus among US adults. Am J Med 123:711\u2013718. https:\/\/doi.org\/10.1016\/j.amjmed.2010.02.015","journal-title":"Am J Med"},{"key":"2784_CR7","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3109\/14992027.2010.551220","volume":"50","author":"DM Nondahl","year":"2011","unstructured":"Nondahl DM, Cruickshanks KJ, Huang GH et al (2011) Tinnitus and its risk factors in the Beaver Dam Offspring Study. Int J Audiol 50:313\u2013320. https:\/\/doi.org\/10.3109\/14992027.2010.551220","journal-title":"Int J Audiol"},{"key":"2784_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/265861","volume":"2010","author":"F Martines","year":"2010","unstructured":"Martines F, Bentivegna D, di Piazza F et al (2010) Investigation of tinnitus patients in Italy: clinical and audiological characteristics. Int J Otolaryngol 2010:1\u20138. https:\/\/doi.org\/10.1155\/2010\/265861","journal-title":"Int J Otolaryngol"},{"key":"2784_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00278-010-0791-2","volume":"56","author":"C Weise","year":"2011","unstructured":"Weise C (2011) Tinnitus. Psychotherapeut 56:61\u201378. https:\/\/doi.org\/10.1007\/s00278-010-0791-2","journal-title":"Psychotherapeut"},{"key":"2784_CR10","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1056\/NEJMra013395","volume":"347","author":"AH Lockwood","year":"2002","unstructured":"Lockwood AH, Salvi RJ, Burkard RF (2002) Tinnitus. N Engl J Med 347:904\u2013910. https:\/\/doi.org\/10.1056\/NEJMra013395","journal-title":"N Engl J Med"},{"key":"2784_CR11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.4081\/audiores.2019.222","volume":"9","author":"A Szibor","year":"2019","unstructured":"Szibor A, M\u00e4kitie A, Aarnisalo AA (2019) Tinnitus and suicide: an unresolved relation. Audiol Res 9:10\u201313. https:\/\/doi.org\/10.4081\/audiores.2019.222","journal-title":"Audiol Res"},{"key":"2784_CR12","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1177\/0194599819835178","volume":"161","author":"JW Salazar","year":"2019","unstructured":"Salazar JW, Meisel K, Smith ER et al (2019) Depression in patients with tinnitus: a systematic review. Otolaryngol Head Neck Surg 161:28\u201335. https:\/\/doi.org\/10.1177\/0194599819835178","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2784_CR13","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1097\/MOO.0b013e32833c718d","volume":"18","author":"MD Seidman","year":"2010","unstructured":"Seidman MD, Standring RT, Dornhoffer JL (2010) Tinnitus: current understanding and contemporary management. Curr Opin Otolaryngol Head Neck Surg 18:363\u2013368","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"2784_CR14","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.3390\/nu12113297","volume":"12","author":"B Gopinath","year":"2020","unstructured":"Gopinath B, McMahon CM, Lewis JR et al (2020) Associations between intake of dietary flavonoids and 10-year incidence of age-related hearing loss. Nutrients 12:3297. https:\/\/doi.org\/10.3390\/nu12113297","journal-title":"Nutrients"},{"key":"2784_CR15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.annepidem.2009.09.002","volume":"20","author":"B Gopinath","year":"2010","unstructured":"Gopinath B, McMahon CM, Rochtchina E et al (2010) Risk factors and impacts of incident tinnitus in older adults. Ann Epidemiol 20:129\u2013135. https:\/\/doi.org\/10.1016\/j.annepidem.2009.09.002","journal-title":"Ann Epidemiol"},{"key":"2784_CR16","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1097\/01.AUD.0000100204.08771.3D","volume":"24","author":"D Sindhusake","year":"2003","unstructured":"Sindhusake D, Golding M, Newall P et al (2003) Risk factors for tinnitus in a population of older adults: the blue mountains hearing study. Ear Hear 24:501\u2013507. https:\/\/doi.org\/10.1097\/01.AUD.0000100204.08771.3D","journal-title":"Ear Hear"},{"key":"2784_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183192","author":"CP Shih","year":"2017","unstructured":"Shih CP, Lin HC, Chung CH et al (2017) Increased risk of tinnitus in patients with chronic kidney disease: a nationwide, population-based cohort study. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0183192","journal-title":"PLoS ONE"},{"key":"2784_CR18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.31128\/AJGP-07-18-4643","volume":"48","author":"M Hofmeister","year":"2019","unstructured":"Hofmeister M (2019) Do dietary factors significantly influence tinnitus? Aust J Gen Pract 48:153\u2013157. https:\/\/doi.org\/10.31128\/AJGP-07-18-4643","journal-title":"Aust J Gen Pract"},{"key":"2784_CR19","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1080\/14992027.2017.1331049","volume":"56","author":"C Spankovich","year":"2017","unstructured":"Spankovich C, Bishop C, Johnson MF et al (2017) Relationship between dietary quality, tinnitus and hearing level: data from the national health and nutrition examination survey, 1999\u20132002. Int J Audiol 56:716\u2013722. https:\/\/doi.org\/10.1080\/14992027.2017.1331049","journal-title":"Int J Audiol"},{"key":"2784_CR20","doi-asserted-by":"publisher","first-page":"158","DOI":"10.21053\/ceo.2017.01221","volume":"11","author":"DY Lee","year":"2018","unstructured":"Lee DY, Kim YH (2018) Relationship between diet and tinnitus: Korea national health and nutrition examination survey. Clin Exp Otorhinolaryngol 11:158\u2013165. https:\/\/doi.org\/10.21053\/ceo.2017.01221","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"2784_CR21","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.3390\/nu12113291","volume":"12","author":"M Tomanic","year":"2020","unstructured":"Tomanic M, Belojevic G, Jovanovic A et al (2020) Dietary factors and tinnitus among adolescents. Nutrients 12:3291. https:\/\/doi.org\/10.3390\/nu12113291","journal-title":"Nutrients"},{"key":"2784_CR22","first-page":"1","volume-title":"Flavonoids\u2014food sources, health benefits, and mechanisms involved","author":"A Koz\u0142owska","year":"2018","unstructured":"Koz\u0142owska A, Szostak-W\u0119gierek D (2018) Flavonoids\u2014food sources, health benefits, and mechanisms involved. Springer, Cham, pp 1\u201327"},{"key":"2784_CR23","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3109\/14992020309078348","volume":"42","author":"D Sindhusake","year":"2003","unstructured":"Sindhusake D, Mitchell P, Newall P et al (2003) Prevalence and characteristics of tinnitus in older adults: the blue mountains hearing study. Int J Audiol 42:289\u2013294. https:\/\/doi.org\/10.3109\/14992020309078348","journal-title":"Int J Audiol"},{"key":"2784_CR24","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1093\/oxfordjournals.aje.a114780","volume":"127","author":"WC Willett","year":"1988","unstructured":"Willett WC, Sampson L, Browne ML et al (1988) The use of a self-administered questionnaire to assess diet four years in the past. Am J Epidemiol 127:188\u2013199","journal-title":"Am J Epidemiol"},{"key":"2784_CR25","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1017\/S1368980007001103","volume":"11","author":"AW Barclay","year":"2008","unstructured":"Barclay AW, Flood VM, Brand-Miller JC, Mitchell P (2008) Validity of carbohydrate, glycaemic index and glycaemic load data obtained using a semi-quantitative food-frequency questionnaire. Public Health Nutr 11:573\u2013580. https:\/\/doi.org\/10.1017\/S1368980007001103","journal-title":"Public Health Nutr"},{"key":"2784_CR26","first-page":"37","volume":"60","author":"VM Flood","year":"2008","unstructured":"Flood VM, Smith W, Rochtchina E, Wang JJ, Mitchell P (2008) Assembling a nutrient database for a large cohort study: blue mountains eye study. Food Aust 60:37\u201340","journal-title":"Food Aust"},{"key":"2784_CR27","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/j.1467-842X.1998.tb01414.x","volume":"22","author":"W Smith","year":"1998","unstructured":"Smith W, Mitchell P, Reay EM et al (1998) Validity and reproducibility of a self-administered food frequency questionnaire in older people. Aust N Z J Public Health 22:456\u2013463. https:\/\/doi.org\/10.1111\/j.1467-842X.1998.tb01414.x","journal-title":"Aust N Z J Public Health"},{"key":"2784_CR28","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/0002-8223(93)91754-E","volume":"93","author":"D Feskanich","year":"1993","unstructured":"Feskanich D, Rimm EB, Giovannucci EL et al (1993) Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire. J Am Diet Assoc 93:790\u2013796. https:\/\/doi.org\/10.1016\/0002-8223(93)91754-E","journal-title":"J Am Diet Assoc"},{"key":"2784_CR29","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1093\/AJCN\/85.3.895","volume":"85","author":"PJ Mink","year":"2007","unstructured":"Mink PJ, Scrafford CG, Barraj LM et al (2007) Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr 85:895\u2013909. https:\/\/doi.org\/10.1093\/AJCN\/85.3.895","journal-title":"Am J Clin Nutr"},{"key":"2784_CR30","volume-title":"USDA database for the flavonoid content of selected foods; release 3.1","author":"U.S. Department for Agriculture","year":"2014","unstructured":"U.S. Department for Agriculture (2014) USDA database for the flavonoid content of selected foods; release 3.1. Agriculture Research Services, Washington"},{"key":"2784_CR31","volume-title":"USDA database for isoflavone content of selected foods; release 2.0","author":"U.S. Department for Agriculture","year":"2008","unstructured":"U.S. Department for Agriculture (2008) USDA database for isoflavone content of selected foods; release 2.0. Agricultural Research Services, Washington"},{"key":"2784_CR32","volume-title":"USDA database for the proanthocyanidin content of selected foods","author":"U.S. Department for Agriculture","year":"2015","unstructured":"U.S. Department for Agriculture (2015) USDA database for the proanthocyanidin content of selected foods. Agricultural Research Services, Washington"},{"key":"2784_CR33","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/OXFORDJOURNALS.AJE.A114366","volume":"124","author":"W Willett","year":"1986","unstructured":"Willett W, Stampfer MJ (1986) Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 124:17\u201327. https:\/\/doi.org\/10.1093\/OXFORDJOURNALS.AJE.A114366","journal-title":"Am J Epidemiol"},{"key":"2784_CR34","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.bcp.2007.11.002","volume":"75","author":"WM Loke","year":"2008","unstructured":"Loke WM, Proudfoot JM, Stewart S et al (2008) Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity. Biochem Pharmacol 75:1045\u20131053. https:\/\/doi.org\/10.1016\/j.bcp.2007.11.002","journal-title":"Biochem Pharmacol"},{"key":"2784_CR35","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1741-7015-9-80","volume":"9","author":"C Borghi","year":"2011","unstructured":"Borghi C, Cosentino ER, Rinaldi ER et al (2011) Tinnitus in elderly patients and prognosis of mild-to-moderate congestive heart failure: a cross-sectional study with a long-term extension of the clinical follow-up. BMC Med 9:80. https:\/\/doi.org\/10.1186\/1741-7015-9-80","journal-title":"BMC Med"},{"key":"2784_CR36","unstructured":"How Does Loud Noise Cause Hearing Loss? | NCEH | CDC. https:\/\/www.cdc.gov\/nceh\/hearing_loss\/how_does_loud_noise_cause_hearing_loss.html. Accessed 25 Feb 2021"},{"key":"2784_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108999","volume":"116","author":"A Rauf","year":"2019","unstructured":"Rauf A, Imran M, Abu-Izneid T et al (2019) Proanthocyanidins: a comprehensive review. Biomed Pharmacother 116:108999","journal-title":"Biomed Pharmacother"},{"key":"2784_CR38","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.1016\/B0-12-227055-X\/00914-7","volume-title":"Encyclopedia of food sciences and nutrition","author":"M Murkovic","year":"2003","unstructured":"Murkovic M (2003) Phenolic compounds. Encyclopedia of food sciences and nutrition. Elsevier, pp 4507\u20134514"},{"key":"2784_CR39","doi-asserted-by":"publisher","first-page":"12134","DOI":"10.1038\/s41598-020-69243-0","volume":"10","author":"H te Chu","year":"2020","unstructured":"te Chu H, Liang C-S, Yeh TC et al (2020) Tinnitus and risk of Alzheimer\u2019s and Parkinson\u2019s disease: a retrospective nationwide population-based cohort study. Sci Rep 10:12134. https:\/\/doi.org\/10.1038\/s41598-020-69243-0","journal-title":"Sci Rep"},{"key":"2784_CR40","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12640-009-9000-x","volume":"15","author":"YJ Wang","year":"2009","unstructured":"Wang YJ, Thomas P, Zhong JH et al (2009) Consumption of grape seed extract prevents amyloid-\u03b2 deposition and attenuates inflammation in brain of an Alzheimer\u2019s disease mouse. Neurotox Res 15:3\u201314. https:\/\/doi.org\/10.1007\/s12640-009-9000-x","journal-title":"Neurotox Res"},{"key":"2784_CR41","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3233\/JAD-2010-1221","volume":"19","author":"MP Murphy","year":"2010","unstructured":"Murphy MP, Levine H (2010) Alzheimer\u2019s disease and the amyloid-\u03b2 peptide. J Alzheimer\u2019s Dis 19:311\u2013323","journal-title":"J Alzheimer\u2019s Dis"},{"key":"2784_CR42","doi-asserted-by":"publisher","first-page":"427","DOI":"10.18632\/aging.100899","volume":"8","author":"Y Omata","year":"2016","unstructured":"Omata Y, Tharasegaran S, Lim YM et al (2016) Expression of amyloid-\u03b2 in mouse cochlear hair cells causes an earlyonset auditory defect in high-frequency sound perception. Aging 8:427\u2013439. https:\/\/doi.org\/10.18632\/aging.100899","journal-title":"Aging"},{"issue":"3","key":"2784_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003852.pub3","volume":"2013","author":"MP Hilton","year":"2013","unstructured":"Hilton MP, Zimmermann EF, Hunt WT (2013) Ginkgo biloba for tinnitus. Cochrane Database Syst Rev 2013(3):CD003852. https:\/\/doi.org\/10.1002\/14651858.CD003852.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"2784_CR44","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00253-003-1527-9","volume":"64","author":"J Smith","year":"2004","unstructured":"Smith J, Luo Y (2004) Studies on molecular mechanisms of Ginkgo biloba extract. Appl Microbiol Biotechnol 64:465\u2013472","journal-title":"Appl Microbiol Biotechnol"},{"key":"2784_CR45","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1001\/archneur.55.11.1409","volume":"55","author":"BS Oken","year":"1998","unstructured":"Oken BS, Storzbach DM, Kaye JA (1998) The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol 55:1409\u20131415","journal-title":"Arch Neurol"},{"key":"2784_CR46","doi-asserted-by":"publisher","first-page":"441","DOI":"10.2147\/NDT.S22793","volume":"7","author":"A von Boetticher","year":"2011","unstructured":"von Boetticher A (2011) Ginkgo biloba extract in the treatment of tinnitus: a systematic review. Neuropsychiatr Dis Treat 7:441\u2013447","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2784_CR47","doi-asserted-by":"publisher","first-page":"188","DOI":"10.5414\/CPP40188","volume":"40","author":"C Morgenstern","year":"2002","unstructured":"Morgenstern C, Biermann E (2002) The efficacy of Ginkgo special extract EGb 761 in patients with tinnitus. Int J Clin Pharmacol Ther 40:188\u2013197. https:\/\/doi.org\/10.5414\/CPP40188","journal-title":"Int J Clin Pharmacol Ther"},{"key":"2784_CR48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1136\/bmj.322.7278.73","volume":"322","author":"S Drew","year":"2001","unstructured":"Drew S, Davies E (2001) Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebo controlled trial. BMJ 322:73\u201375. https:\/\/doi.org\/10.1136\/bmj.322.7278.73","journal-title":"BMJ"},{"key":"2784_CR49","first-page":"625","volume":"48","author":"K Gohil","year":"2002","unstructured":"Gohil K, Packer L (2002) Global gene expression analysis identifies cell and tissue specific actions of Ginkgo biloba extract, EGb 761. Cell Mol Biol 48:625\u2013631","journal-title":"Cell Mol Biol"},{"key":"2784_CR50","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3233\/jad-2003-5404","volume":"5","author":"JV Smith","year":"2003","unstructured":"Smith JV, Luo Y (2003) Elevation of oxidative free radicals in Alzheimer\u2019s disease models can be attenuated by Ginkgo biloba extract EGb 761. J Alzheimer\u2019s Dis 5:287\u2013300. https:\/\/doi.org\/10.3233\/jad-2003-5404","journal-title":"J Alzheimer\u2019s Dis"},{"key":"2784_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep14633","volume":"5","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Chen S, Mei H et al (2015) Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. Sci Rep 5:1\u201313. https:\/\/doi.org\/10.1038\/srep14633","journal-title":"Sci Rep"},{"key":"2784_CR52","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0079-6123(07)66029-4","volume":"166","author":"P Enrico","year":"2007","unstructured":"Enrico P, Sirca D, Mereu M (2007) Antioxidants, minerals, vitamins, and herbal remedies in tinnitus therapy. Prog Brain Res 166:323\u2013330","journal-title":"Prog Brain Res"},{"key":"2784_CR53","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/ajcn\/nqy114","volume":"108","author":"B Gopinath","year":"2018","unstructured":"Gopinath B, Liew G, Kifley A et al (2018) Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration. Am J Clin Nutr 108:381\u2013387. https:\/\/doi.org\/10.1093\/ajcn\/nqy114","journal-title":"Am J Clin Nutr"},{"key":"2784_CR54","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/J.CLNU.2019.01.004","volume":"39","author":"NP Bondonno","year":"2020","unstructured":"Bondonno NP, Lewis JR, Blekkenhorst LC et al (2020) Association of flavonoids and flavonoid-rich foods with all-cause mortality: The Blue Mountains Eye Study. Clin Nutr 39:141\u2013150. https:\/\/doi.org\/10.1016\/J.CLNU.2019.01.004","journal-title":"Clin Nutr"},{"key":"2784_CR55","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/AJCN\/69.2.261","volume":"69","author":"K Klipstein-Grobusch","year":"1999","unstructured":"Klipstein-Grobusch K, Geleijnse JM, den Breeijen JH et al (1999) Dietary antioxidants and risk of myocardial infarction in the elderly: the Rotterdam Study. Am J Clin Nutr 69:261\u2013266. https:\/\/doi.org\/10.1093\/AJCN\/69.2.261","journal-title":"Am J Clin Nutr"},{"key":"2784_CR56","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.3945\/AJCN.2008.27064","volume":"89","author":"MF Engberink","year":"2009","unstructured":"Engberink MF, Hendriksen MAH, Schouten EG et al (2009) Inverse association between dairy intake and hypertension: the Rotterdam Study. Am J Clin Nutr 89:1877\u20131883. https:\/\/doi.org\/10.3945\/AJCN.2008.27064","journal-title":"Am J Clin Nutr"},{"key":"2784_CR57","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1093\/AJCN\/75.5.880","volume":"75","author":"JM Geleijnse","year":"2002","unstructured":"Geleijnse JM, Launer LJ, van der Kuip DAM et al (2002) Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study. Am J Clin Nutr 75:880\u2013886. https:\/\/doi.org\/10.1093\/AJCN\/75.5.880","journal-title":"Am J Clin Nutr"},{"key":"2784_CR58","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1001\/jama.294.24.3101","volume":"294","author":"R van Leeuwen","year":"2005","unstructured":"van Leeuwen R, Boekhoorn S, Vingerling JR et al (2005) Dietary intake of antioxidants and risk of age-related macular degeneration. J Am Med Assoc 294:3101\u20133107. https:\/\/doi.org\/10.1001\/jama.294.24.3101","journal-title":"J Am Med Assoc"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-021-02784-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-021-02784-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-021-02784-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T04:07:26Z","timestamp":1652501246000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-021-02784-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,24]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["2784"],"URL":"https:\/\/doi.org\/10.1007\/s00394-021-02784-w","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,24]]},"assertion":[{"value":"15 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors declared a conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The BMHS was conducted in accordance with the Declaration of Helsinki and was approved by The University of Sydney Human Research Ethics Committee (Reference: HREC 9826).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from each participant prior to enrolment.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written informed consent was obtained from each participant prior to enrolment about publication of study findings.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publication"}}]}}