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The bone turnover markers osteocalcin (OC), C-terminal telopeptides of type 1 collagen (CTX) and total alkaline phosphatase were quantified in serum along with urinary creatinine corrected deoxypyridinoline (DPD\/Cr) and CTX\/Cr and the CTX:OC ratio calculated. Total serum n-6 PUFA (LA\u2009+\u2009AA) and n\u2009\u2212\u20093 LCPUFA (ALA\u2009+\u2009EPA\u2009+\u2009DPA\u2009+\u2009DHA) were measured and the n\u2009\u2212\u20096:n\u2009\u2212\u20093 ratio was calculated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean (SD) age and body mass index (BMI) were 61 (6.4) years and 27.4 (4.8) kg\/m<jats:sup>2<\/jats:sup>, respectively with participants being 12.6 (7.6) years post-menopause. Multiple regression analysis identified no association between n-3 LCPUFA and any of the measures of T-score or BMD albeit a significant positive association between total n\u2009\u2212\u20093 LCPUFA and femur BMD (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.287; <jats:italic>p<\/jats:italic>\u2009=\u20090.043) was observed within those women with a low n\u2009\u2212\u20096:n\u2009\u2212\u20093 ratio. There was a significant inverse association between ALA and urinary DPD\/Cr (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u2212\u20090.141; <jats:italic>p<\/jats:italic>\u2009=\u20090.016).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A favourable low n\u2009\u2212\u20096:n\u2009\u2212\u20093 ratio was associated with higher femur BMD and a higher n\u2009\u2212\u20093 LCPUFA (ALA) was associated with lower bone resorption. These results support a beneficial role for n\u2009\u2212\u20093 LCPUFA in reducing postmenopausal bone resorption and favourably influencing BMD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial number &amp; date of registration<\/jats:title>\n                <jats:p>ISRCTN63118444, 2nd October 2009, \u201cRetrospectively registered\u201d.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00394-022-02933-9","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T21:02:32Z","timestamp":1659214952000},"page":"95-104","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Associations of long chain polyunsaturated fatty acids with bone mineral density and bone turnover in postmenopausal women"],"prefix":"10.1007","volume":"62","clinical-trial-number":[{"clinical-trial-number":"isrctn63118444","registry":"10.18810\/isrctn"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-1300","authenticated-orcid":false,"given":"Orlagh","family":"Feehan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0479-3314","authenticated-orcid":false,"given":"Pamela Jane","family":"Magee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2251-5251","authenticated-orcid":false,"given":"Laura Kirsty","family":"Pourshahidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-8602","authenticated-orcid":false,"given":"David John","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3891-6543","authenticated-orcid":false,"given":"Mary Martina","family":"Slevin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-162X","authenticated-orcid":false,"given":"Philip James","family":"Allsopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3219-7595","authenticated-orcid":false,"given":"Marie Catherine","family":"Conway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1633-2873","authenticated-orcid":false,"given":"J J","family":"Strain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-3991","authenticated-orcid":false,"given":"Emeir Mary","family":"McSorley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"issue":"6","key":"2933_CR1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3390\/nu8060376","volume":"8","author":"MC Kruger","year":"2016","unstructured":"Kruger MC, Wolber FM (2016) Osteoporosis: modern paradigms for last century\u2019s bones. 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