{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:40:00Z","timestamp":1788910800429,"version":"build-2803163510"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001554","name":"Massey University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001554","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Curcumin, a natural polyphenol extracted from turmeric, is a potent antioxidant and anti-inflammatory agent. In the past few decades, curcumin\u2019s ability to impact chronic inflammatory conditions such as metabolic syndrome, arthritis, and cancer has been widely researched, along with growing interest in understanding its role in exercise-induced muscle damage (EIMD). EIMD impacts individuals differently depending on the type (resistance exercise, high-intensity interval training, and running), intensity, and duration of the exercise. Exercise disrupts the muscles\u2019 ultrastructure, raises inflammatory cytokine levels, and can cause swelling in the affected limb, a reduction in range of motion (ROM), and a reduction in muscular force-producing capacity. This review focuses on the metabolism, pharmacokinetics of various brands of curcumin supplements, and the effect of curcumin supplementation on EIMD regarding muscle soreness, activity of creatine kinase (CK), and production of inflammatory markers. Curcumin supplementation in the dose range of 90\u20135000\u00a0mg\/day can decrease the subjective perception of muscle pain intensity, increase antioxidant capacity, and reduce CK activity, which reduces muscle damage when consumed close to exercise. Consumption of curcumin also improves muscle performance and has an anti-inflammatory effect, downregulating the production of pro-inflammatory cytokines, including TNF-<jats:italic>\u03b1<\/jats:italic>, IL-6, and IL-8. Curcumin may also improve oxidative capacity without hampering training adaptations in untrained and recreationally active individuals. The optimal curcumin dose to ameliorate EIMD is challenging to assess as its effect depends on the curcumin concentration in the supplement and its bioavailability.\n<\/jats:p>","DOI":"10.1007\/s00394-022-02943-7","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T22:04:56Z","timestamp":1657749896000},"page":"3835-3855","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-3185","authenticated-orcid":false,"given":"K.","family":"Nanavati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-3786","authenticated-orcid":false,"given":"K.","family":"Rutherfurd-Markwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0634-1984","authenticated-orcid":false,"given":"S. J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6221-3907","authenticated-orcid":false,"given":"N. C.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-1435","authenticated-orcid":false,"given":"A.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"issue":"9","key":"2943_CR1","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.3390\/nu11092147","volume":"11","author":"M Dei Cas","year":"2019","unstructured":"Dei Cas M, Ghidoni R (2019) Dietary Curcumin: Correlation between Bioavailability and Health Potential. Nutrients 11(9):2147. https:\/\/doi.org\/10.3390\/nu11092147","journal-title":"Nutrients"},{"issue":"12","key":"2943_CR2","doi-asserted-by":"publisher","first-page":"20091","DOI":"10.3390\/molecules191220091","volume":"19","author":"KI Priyadarsini","year":"2014","unstructured":"Priyadarsini KI (2014) The chemistry of curcumin: from extraction to therapeutic agent. Molecules 19(12):20091\u201320112. https:\/\/doi.org\/10.3390\/molecules191220091","journal-title":"Molecules"},{"key":"2943_CR3","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.biopha.2016.05.037","volume":"82","author":"Y Panahi","year":"2016","unstructured":"Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mend\u00eda LE, Majeed M, Sahebkar A (2016) Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: a post-hoc analysis of a randomized controlled trial. Biomed Pharmacother 82:578\u2013582. https:\/\/doi.org\/10.1016\/j.biopha.2016.05.037","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"2943_CR4","first-page":"337","volume":"15","author":"G Belcaro","year":"2010","unstructured":"Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G (2010) Efficacy and safety of Meriva\u00ae, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev 15(4):337\u2013344","journal-title":"Altern Med Rev"},{"issue":"1","key":"2943_CR5","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/2193-1801-2-56","volume":"2","author":"Y Henrotin","year":"2013","unstructured":"Henrotin Y, Priem F, Mobasheri A (2013) Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus 2(1):56. https:\/\/doi.org\/10.1186\/2193-1801-2-56","journal-title":"Springerplus"},{"issue":"10","key":"2943_CR6","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.phymed.2009.04.008","volume":"16","author":"Q Liu","year":"2009","unstructured":"Liu Q, Loo WT, Sze SC, Tong Y (2009) Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription. Phytomedicine 16(10):916\u2013922. https:\/\/doi.org\/10.1016\/j.phymed.2009.04.008","journal-title":"Phytomedicine"},{"issue":"6","key":"2943_CR7","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.3892\/or.2015.4279","volume":"34","author":"L Wu","year":"2015","unstructured":"Wu L, Guo L, Liang Y, Liu X, Jiang L, Wang L (2015) Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2\/STAT3 signaling pathway. Oncol Rep 34(6):3311\u20133317. https:\/\/doi.org\/10.3892\/or.2015.4279","journal-title":"Oncol Rep"},{"issue":"1","key":"2943_CR8","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","volume":"46","author":"S Prasad","year":"2014","unstructured":"Prasad S, Tyagi AK, Aggarwal BB (2014) Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat 46(1):2\u201318. https:\/\/doi.org\/10.4143\/crt.2014.46.1.2","journal-title":"Cancer Res Treat"},{"issue":"5","key":"2943_CR9","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1152\/jappl.1997.83.5.1482","volume":"83","author":"S Asp","year":"1997","unstructured":"Asp S, Rohde T, Richter EA (1997) Impaired muscle glycogen resynthesis after a marathon is not caused by decreased muscle GLUT-4 content. J Appl Physiol (1985) 83(5):1482\u20131485. https:\/\/doi.org\/10.1152\/jappl.1997.83.5.1482","journal-title":"J Appl Physiol (1985)"},{"issue":"(Pt 3)","key":"2943_CR10","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1113\/jphysiol.1995.sp020553","volume":"482","author":"S Asp","year":"1995","unstructured":"Asp S, Daugaard JR, Richter EA (1995) Eccentric exercise decreases glucose transporter GLUT4 protein in human skeletal muscle. J Physiol 482((Pt 3)):705\u2013712. https:\/\/doi.org\/10.1113\/jphysiol.1995.sp020553","journal-title":"J Physiol"},{"issue":"4","key":"2943_CR11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1080\/17461391.2013.783628","volume":"14","author":"DG Burt","year":"2014","unstructured":"Burt DG, Lamb K, Nicholas C, Twist C (2014) Effects of exercise-induced muscle damage on resting metabolic rate, sub-maximal running and post-exercise oxygen consumption. Eur J Sport Sci 14(4):337\u2013344. https:\/\/doi.org\/10.1080\/17461391.2013.783628","journal-title":"Eur J Sport Sci"},{"issue":"12","key":"2943_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243276","volume":"15","author":"JH Gomes","year":"2020","unstructured":"Gomes JH, Mendes RR, Franca CS, Da Silva-Grigoletto ME, Pereira da Silva DR, Antoniolli AR, de Oliveira ESAM, Quintans-J\u00fanior LJ (2020) Acute leucocyte, muscle damage, and stress marker responses to high-intensity functional training. PLoS ONE 15(12):e0243276. https:\/\/doi.org\/10.1371\/journal.pone.0243276","journal-title":"PLoS ONE"},{"issue":"2","key":"2943_CR13","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1123\/ijspp.2018-0882","volume":"15","author":"N Giovanelli","year":"2020","unstructured":"Giovanelli N, Biasutti L, Salvadego D, Alemayehu HK, Grassi B, Lazzer S (2020) Changes in skeletal muscle oxidative capacity after a trail running race. Int J Sports Physiol Perform 15(2):278\u2013284. https:\/\/doi.org\/10.1123\/ijspp.2018-0882","journal-title":"Int J Sports Physiol Perform"},{"key":"2943_CR14","doi-asserted-by":"publisher","unstructured":"Giovanelli N, Lazzer S, Cauci S (2020) Muscle damage and inflammatory status biomarkers after a 3-stage trail running race. J Sports Med Phys Fitness 60(11):1486\u20131492. https:\/\/doi.org\/10.23736\/s0022-4707.20.10997-6","DOI":"10.23736\/s0022-4707.20.10997-6"},{"issue":"12","key":"2943_CR15","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1007\/s40279-020-01355-z","volume":"50","author":"B Bontemps","year":"2020","unstructured":"Bontemps B, Vercruyssen F, Gruet M, Louis J (2020) Downhill running: what are the effects and how can we adapt? A narrative review? Sports Med 50(12):2083\u20132110. https:\/\/doi.org\/10.1007\/s40279-020-01355-z","journal-title":"Sports Med"},{"issue":"1","key":"2943_CR16","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2165\/00007256-200434010-00005","volume":"34","author":"C Byrne","year":"2004","unstructured":"Byrne C, Twist C, Eston R (2004) Neuromuscular function after exercise-induced muscle damage: theoretical and applied implications. Sports Med 34(1):49\u201369. https:\/\/doi.org\/10.2165\/00007256-200434010-00005","journal-title":"Sports Med"},{"issue":"2","key":"2943_CR17","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/mus.24077","volume":"49","author":"RD Hyldahl","year":"2014","unstructured":"Hyldahl RD, Hubal MJ (2014) Lengthening our perspective: morphological, cellular, and molecular responses to eccentric exercise. Muscle Nerve 49(2):155\u2013170. https:\/\/doi.org\/10.1002\/mus.24077","journal-title":"Muscle Nerve"},{"issue":"1","key":"2943_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13395-017-0142-x","volume":"7","author":"AL Mackey","year":"2017","unstructured":"Mackey AL, Kjaer M (2017) The breaking and making of healthy adult human skeletal muscle in vivo. Skelet Muscle 7(1):24. https:\/\/doi.org\/10.1186\/s13395-017-0142-x","journal-title":"Skelet Muscle"},{"key":"2943_CR19","doi-asserted-by":"publisher","unstructured":"Nakhostin-Roohi B, Nasirvand Moradlou A, Mahmoodi Hamidabad S, Ghanivand B (2016) The effect of curcumin supplementation on selected markers of Delayed Onset Muscle Soreness (DOMS). Ann Appl Sport Sci 4 (2):25\u201331. https:\/\/doi.org\/10.18869\/acadpub.aassjournal.4.2.25","DOI":"10.18869\/acadpub.aassjournal.4.2.25"},{"issue":"5","key":"2943_CR20","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1089\/jmf.2019.4533","volume":"23","author":"A Amalraj","year":"2020","unstructured":"Amalraj A, Divya C, Gopi S (2020) The effects of bioavailable curcumin (cureit) on delayed onset muscle soreness induced by eccentric continuous exercise: a randomized, placebo-controlled double-blind clinical study. J Med Food 23(5):545\u2013553. https:\/\/doi.org\/10.1089\/jmf.2019.4533","journal-title":"J Med Food"},{"issue":"8","key":"2943_CR21","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1007\/s00421-015-3152-6","volume":"115","author":"LM Nicol","year":"2015","unstructured":"Nicol LM, Rowlands DS, Fazakerly R, Kellett J (2015) Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol 115(8):1769\u20131777. https:\/\/doi.org\/10.1007\/s00421-015-3152-6","journal-title":"Eur J Appl Physiol"},{"issue":"4","key":"2943_CR22","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1111\/sms.13373","volume":"29","author":"Y Tanabe","year":"2019","unstructured":"Tanabe Y, Chino K, Ohnishi T, Ozawa H, Sagayama H, Maeda S, Takahashi H (2019) Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. Scand J Med Sci Sports 29(4):524\u2013534. https:\/\/doi.org\/10.1111\/sms.13373","journal-title":"Scand J Med Sci Sports"},{"issue":"1","key":"2943_CR23","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3177\/jnsv.65.82","volume":"65","author":"Y Tanabe","year":"2019","unstructured":"Tanabe Y, Chino K, Sagayama H, Lee HJ, Ozawa H, Maeda S, Takahashi H (2019) Effective timing of curcumin ingestion to attenuate eccentric exercise-induced muscle soreness in Men. J Nutr Sci Vitaminol (Tokyo) 65(1):82\u201389. https:\/\/doi.org\/10.3177\/jnsv.65.82","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"2943_CR24","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.bbacli.2016.02.003","volume":"5","author":"BK McFarlin","year":"2016","unstructured":"McFarlin BK, Venable AS, Henning AL, Sampson JN, Pennel K, Vingren JL, Hill DW (2016) Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin 5:72\u201378. https:\/\/doi.org\/10.1016\/j.bbacli.2016.02.003","journal-title":"BBA Clin"},{"issue":"6","key":"2943_CR25","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1055\/s-0033-1357185","volume":"35","author":"M Takahashi","year":"2014","unstructured":"Takahashi M, Suzuki K, Kim HK, Otsuka Y, Imaizumi A, Miyashita M, Sakamoto S (2014) Effects of curcumin supplementation on exercise-induced oxidative stress in humans. Int J Sports Med 35(6):469\u2013475. https:\/\/doi.org\/10.1055\/s-0033-1357185","journal-title":"Int J Sports Med"},{"key":"2943_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19390211.2019.1604604","volume":"17","author":"SA Basham","year":"2019","unstructured":"Basham SA, Waldman HS, Krings BM, Lamberth J, Smith JW, McAllister MJ (2019) Effect of curcumin supplementation on exercise-induced oxidative stress, inflammation, muscle damage, and muscle soreness. J Diet Suppl 17:1\u201314. https:\/\/doi.org\/10.1080\/19390211.2019.1604604","journal-title":"J Diet Suppl"},{"issue":"6","key":"2943_CR27","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/sj.bjp.0706923","volume":"149","author":"I Dey","year":"2006","unstructured":"Dey I, Lejeune M, Chadee K (2006) Prostaglandin E2 receptor distribution and function in the gastrointestinal tract. Br J Pharmacol 149(6):611\u2013623. https:\/\/doi.org\/10.1038\/sj.bjp.0706923","journal-title":"Br J Pharmacol"},{"issue":"12","key":"2943_CR28","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/BF03262309","volume":"42","author":"BJ Schoenfeld","year":"2012","unstructured":"Schoenfeld BJ (2012) The use of nonsteroidal anti-inflammatory drugs for exercise-induced muscle damage. Sports Med 42(12):1017\u20131028. https:\/\/doi.org\/10.1007\/BF03262309","journal-title":"Sports Med"},{"key":"2943_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-0-387-46401-5_1","volume":"595","author":"BB Aggarwal","year":"2007","unstructured":"Aggarwal BB, Sundaram C, Malani N, Ichikawa H (2007) Curcumin: the Indian solid gold. Adv Exp Med Biol 595:1\u201375. https:\/\/doi.org\/10.1007\/978-0-387-46401-5_1","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"2943_CR30","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1249\/00005768-199205000-00004","volume":"24","author":"PM Clarkson","year":"1992","unstructured":"Clarkson PM, Nosaka K, Braun B (1992) Muscle function after exercise-induced muscle damage and rapid adaptation. Med Sci Sports Exerc 24(5):512\u2013520","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"2943_CR31","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1254\/jphs.10126sc","volume":"114","author":"K Moriyuki","year":"2010","unstructured":"Moriyuki K, Sekiguchi F, Matsubara K, Nishikawa H, Kawabata A (2010) Curcumin Inhibits the proteinase-activated receptor-2-triggered prostaglandin E2 production by suppressing cyclooxygenase-2 upregulation and Akt-dependent activation of nuclear factor-\u03baB in human lung epithelial cells. J Pharmacol Sci 114(2):225\u2013229. https:\/\/doi.org\/10.1254\/jphs.10126sc","journal-title":"J Pharmacol Sci"},{"issue":"2","key":"2943_CR32","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1042\/bj2290409","volume":"229","author":"MK Bijsterbosch","year":"1985","unstructured":"Bijsterbosch MK, Duursma AM, Smit MJ, Bos OJ, Bouma JM, Gruber M (1985) Several dehydrogenases and kinases compete for endocytosis from plasma by rat tissues. Biochem J 229(2):409\u2013417. https:\/\/doi.org\/10.1042\/bj2290409","journal-title":"Biochem J"},{"issue":"18","key":"2943_CR33","doi-asserted-by":"publisher","first-page":"5135","DOI":"10.1113\/jp270654","volume":"594","author":"TL Merry","year":"2016","unstructured":"Merry TL, Ristow M (2016) Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? J Physiol 594(18):5135\u20135147. https:\/\/doi.org\/10.1113\/jp270654","journal-title":"J Physiol"},{"issue":"12","key":"2943_CR34","doi-asserted-by":"publisher","first-page":"4490","DOI":"10.1021\/ja809217u","volume":"131","author":"J Barry","year":"2009","unstructured":"Barry J, Fritz M, Brender JR, Smith PE, Lee DK, Ramamoorthy A (2009) Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin. J Am Chem Soc 131(12):4490\u20134498. https:\/\/doi.org\/10.1021\/ja809217u","journal-title":"J Am Chem Soc"},{"issue":"5","key":"2943_CR35","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s10787-019-00607-3","volume":"27","author":"K Kahkhaie","year":"2019","unstructured":"Kahkhaie K, Mirhosseini A, Aliabadi A, Mohammadi A, Mousavi M, Haftcheshmeh S, Sathyapalan T, Sahebkar A (2019) Curcumin: a modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology 27(5):885\u2013900. https:\/\/doi.org\/10.1007\/s10787-019-00607-3","journal-title":"Inflammopharmacology"},{"issue":"11","key":"2943_CR36","first-page":"2032","volume":"19","author":"A Noorafshan","year":"2013","unstructured":"Noorafshan A, Ashkani-Esfahani S (2013) A review of therapeutic effects of curcumin. Curr Pharm Des 19(11):2032\u20132046","journal-title":"Curr Pharm Des"},{"issue":"12","key":"2943_CR37","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1056\/NEJMoa1114287","volume":"367","author":"R Gold","year":"2012","unstructured":"Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Tornatore C, Sweetser MT, Yang M, Sheikh SI, Dawson KT (2012) Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 367(12):1098\u20131107. https:\/\/doi.org\/10.1056\/NEJMoa1114287","journal-title":"N Engl J Med"},{"issue":"4b","key":"2943_CR38","first-page":"2895","volume":"21","author":"AL Cheng","year":"2001","unstructured":"Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY (2001) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21(4b):2895\u20132900","journal-title":"Anticancer Res"},{"issue":"6","key":"2943_CR39","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.biotechadv.2014.04.004","volume":"32","author":"S Prasad","year":"2014","unstructured":"Prasad S, Gupta SC, Tyagi AK, Aggarwal BB (2014) Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv 32(6):1053\u20131064. https:\/\/doi.org\/10.1016\/j.biotechadv.2014.04.004","journal-title":"Biotechnol Adv"},{"issue":"6","key":"2943_CR40","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/mp700113r","volume":"4","author":"P Anand","year":"2007","unstructured":"Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4(6):807\u2013818. https:\/\/doi.org\/10.1021\/mp700113r","journal-title":"Mol Pharm"},{"issue":"5","key":"2943_CR41","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1248\/bpb.34.660","volume":"34","author":"H Sasaki","year":"2011","unstructured":"Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T (2011) Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull 34(5):660\u2013665. https:\/\/doi.org\/10.1248\/bpb.34.660","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"2943_CR42","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1021\/np1007262","volume":"74","author":"J Cuomo","year":"2011","unstructured":"Cuomo J, Appendino G, Dern AS, Schneider E, McKinnon TP, Brown MJ, Togni S, Dixon BM (2011) Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod 74(4):664\u2013669. https:\/\/doi.org\/10.1021\/np1007262","journal-title":"J Nat Prod"},{"issue":"3","key":"2943_CR43","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/mnfr.201300724","volume":"58","author":"C Schiborr","year":"2014","unstructured":"Schiborr C, Kocher A, Behnam D, Jandasek J, Toelstede S, Frank J (2014) The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res 58(3):516\u2013527. https:\/\/doi.org\/10.1002\/mnfr.201300724","journal-title":"Mol Nutr Food Res"},{"issue":"4","key":"2943_CR44","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1021\/jf9024807","volume":"58","author":"VS Gota","year":"2010","unstructured":"Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG (2010) Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem 58(4):2095\u20132099. https:\/\/doi.org\/10.1021\/jf9024807","journal-title":"J Agric Food Chem"},{"issue":"1","key":"2943_CR45","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1124\/pr.110.004044","volume":"66","author":"M Heger","year":"2014","unstructured":"Heger M, van Golen RF, Broekgaarden M, Michel MC (2014) The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer. Pharmacol Rev 66(1):222\u2013307. https:\/\/doi.org\/10.1124\/pr.110.004044","journal-title":"Pharmacol Rev"},{"issue":"16","key":"2943_CR46","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.1021\/acs.jafc.7b00943","volume":"65","author":"S Burapan","year":"2017","unstructured":"Burapan S, Kim M, Han J (2017) Curcuminoid demethylation as an alternative metabolism by human intestinal microbiota. J Agric Food Chem 65(16):3305\u20133310. https:\/\/doi.org\/10.1021\/acs.jafc.7b00943","journal-title":"J Agric Food Chem"},{"issue":"4","key":"2943_CR47","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.joim.2019.05.002","volume":"17","author":"R Jamwal","year":"2019","unstructured":"Jamwal R (2019) Corrigendum: bioavailable curcumin formulations: a review of pharmacokinetic studies in healthy volunteers. J Integr Med 17(4):310. https:\/\/doi.org\/10.1016\/j.joim.2019.05.002","journal-title":"J Integr Med"},{"issue":"1","key":"2943_CR48","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s12906-019-2699-x","volume":"19","author":"SJ Stohs","year":"2019","unstructured":"Stohs SJ, Chen CYO, Preuss HG, Ray SD, Bucci LR, Ji J, Ruff KJ (2019) The fallacy of enzymatic hydrolysis for the determination of bioactive curcumin in plasma samples as an indication of bioavailability: a comparative study. BMC Complement Altern Med 19(1):293. https:\/\/doi.org\/10.1186\/s12906-019-2699-x","journal-title":"BMC Complement Altern Med"},{"issue":"1","key":"2943_CR49","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.jff.2012.01.004","volume":"4","author":"K Im","year":"2012","unstructured":"Im K, Ravi A, Kumar D, Kuttan R, Maliakel B (2012) An enhanced bioavailable formulation of curcumin using fenugreek-derived soluble dietary fibre. J Funct Foods 4(1):348\u2013357. https:\/\/doi.org\/10.1016\/j.jff.2012.01.004","journal-title":"J Funct Foods"},{"issue":"4","key":"2943_CR50","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1055\/s-2006-957450","volume":"64","author":"G Shoba","year":"1998","unstructured":"Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS (1998) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64(4):353\u2013356. https:\/\/doi.org\/10.1055\/s-2006-957450","journal-title":"Planta Med"},{"key":"2943_CR51","doi-asserted-by":"publisher","first-page":"9159281","DOI":"10.1155\/2018\/9159281","volume":"2018","author":"NT Krishnareddy","year":"2018","unstructured":"Krishnareddy NT, Thomas JV, Nair SS, Mulakal JN, Maliakel BP, Krishnakumar M (2018) A novel curcumin-galactomannoside complex delivery system improves hepatic function markers in chronic alcoholics: a double-blinded, randomized placebo-controlled study. Biomed Res Int 2018:9159281. https:\/\/doi.org\/10.1155\/2018\/9159281","journal-title":"Biomed Res Int"},{"issue":"1","key":"2943_CR52","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12970-014-0066-3","volume":"12","author":"JN Sciberras","year":"2015","unstructured":"Sciberras JN, Galloway SD, Fenech A, Grech G, Farrugia C, Duca D, Mifsud J (2015) The effect of turmeric (Curcumin) supplementation on cytokine and inflammatory marker responses following 2 hours of endurance cycling. J Int Soc Sports Nutr 12(1):5. https:\/\/doi.org\/10.1186\/s12970-014-0066-3","journal-title":"J Int Soc Sports Nutr"},{"issue":"9","key":"2943_CR53","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1007\/s00421-015-3170-4","volume":"115","author":"Y Tanabe","year":"2015","unstructured":"Tanabe Y, Maeda S, Akazawa N, Zempo-Miyaki A, Choi Y, Ra SG, Imaizumi A, Otsuka Y, Nosaka K (2015) Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin. Eur J Appl Physiol 115(9):1949\u20131957. https:\/\/doi.org\/10.1007\/s00421-015-3170-4","journal-title":"Eur J Appl Physiol"},{"issue":"12","key":"2943_CR54","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.1519\/jsc.0000000000003852","volume":"34","author":"LP Herrick","year":"2020","unstructured":"Herrick LP, Goh J, Menke W, Campbell MS, Fleenor BS, Abel MG, Bergstrom HC (2020) Effects of curcumin and fenugreek soluble fiber on the physical working capacity at the fatigue threshold, peak oxygen consumption, and time to exhaustion. J Strength Cond Res 34(12):3346\u20133355. https:\/\/doi.org\/10.1519\/jsc.0000000000003852","journal-title":"J Strength Cond Res"},{"issue":"4","key":"2943_CR55","doi-asserted-by":"publisher","first-page":"337","DOI":"10.32098\/mltj.04.2013.16","volume":"3","author":"TA J\u00e4rvinen","year":"2013","unstructured":"J\u00e4rvinen TA, J\u00e4rvinen M, Kalimo H (2013) Regeneration of injured skeletal muscle after the injury. Muscles Ligaments Tendons J 3(4):337\u2013345","journal-title":"Muscles Ligaments Tendons J"},{"issue":"2","key":"2943_CR56","doi-asserted-by":"publisher","first-page":"S78","DOI":"10.1007\/s000110050284","volume":"47","author":"JR Vane","year":"1998","unstructured":"Vane JR, Botting RM (1998) Anti-inflammatory drugs and their mechanism of action. Inflamm Res 47(2):S78-87. https:\/\/doi.org\/10.1007\/s000110050284","journal-title":"Inflamm Res"},{"issue":"7","key":"2943_CR57","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.3390\/nu11071692","volume":"11","author":"R J\u00e4ger","year":"2019","unstructured":"J\u00e4ger R, Purpura M, Kerksick CM (2019) Eight weeks of a high dose of curcumin supplementation may attenuate performance decrements following muscle-damaging exercise. Nutrients 11(7):1692. https:\/\/doi.org\/10.3390\/nu11071692","journal-title":"Nutrients"},{"issue":"6","key":"2943_CR58","doi-asserted-by":"publisher","first-page":"R667","DOI":"10.1152\/ajpregu.00336.2011","volume":"302","author":"L Vella","year":"2012","unstructured":"Vella L, Caldow MK, Larsen AE, Tassoni D, Della Gatta PA, Gran P, Russell AP, Cameron-Smith D (2012) Resistance exercise increases NF-\u03baB activity in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol 302(6):R667-673. https:\/\/doi.org\/10.1152\/ajpregu.00336.2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"2943_CR59","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3390\/nu12020501","volume":"12","author":"D Fernandez-Lazaro","year":"2020","unstructured":"Fernandez-Lazaro D, Mielgo-Ayuso J, Seco Calvo J, Cordova Martinez A, Caballero Garcia A, Fernandez-Lazaro CI (2020) Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review. Nutrients 12(2):501. https:\/\/doi.org\/10.3390\/nu12020501","journal-title":"Nutrients"},{"key":"2943_CR60","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1113\/jphysiol.1986.sp016126","volume":"375","author":"DA Jones","year":"1986","unstructured":"Jones DA, Newham DJ, Round JM, Tolfree SE (1986) Experimental human muscle damage: morphological changes in relation to other indices of damage. J Physiol 375:435\u2013448. https:\/\/doi.org\/10.1113\/jphysiol.1986.sp016126","journal-title":"J Physiol"},{"issue":"1","key":"2943_CR61","first-page":"147","volume":"16","author":"B Delecroix","year":"2017","unstructured":"Delecroix B, Aba\u00efdia AE, Leduc C, Dawson B, Dupont G (2017) Curcumin and piperine supplementation and recovery following exercise induced muscle damage: a randomized controlled trial. J Sports Sci Med 16(1):147\u2013153","journal-title":"J Sports Sci Med"},{"issue":"1","key":"2943_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.csm.2007.09.005","volume":"27","author":"P Brancaccio","year":"2008","unstructured":"Brancaccio P, Maffulli N, Buonauro R, Limongelli FM (2008) Serum enzyme monitoring in sports medicine. Clin Sports Med 27(1):1\u201318, vii. https:\/\/doi.org\/10.1016\/j.csm.2007.09.005","journal-title":"Clin Sports Med"},{"key":"2943_CR63","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1093\/bmb\/ldm014","volume":"81\u201382","author":"P Brancaccio","year":"2007","unstructured":"Brancaccio P, Maffulli N, Limongelli FM (2007) Creatine kinase monitoring in sport medicine. Br Med Bull 81\u201382:209\u2013230. https:\/\/doi.org\/10.1093\/bmb\/ldm014","journal-title":"Br Med Bull"},{"issue":"6","key":"2943_CR64","doi-asserted-by":"publisher","first-page":"R2168","DOI":"10.1152\/ajpregu.00858.2006","volume":"292","author":"JM Davis","year":"2007","unstructured":"Davis JM, Murphy EA, Carmichael MD, Zielinski MR, Groschwitz CM, Brown AS, Gangemi JD, Ghaffar A, Mayer EP (2007) Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol 292(6):R2168-2173. https:\/\/doi.org\/10.1152\/ajpregu.00858.2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"2943_CR65","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1002\/cphy.c100054","volume":"1","author":"SK Powers","year":"2011","unstructured":"Powers SK, Ji LL, Kavazis AN, Jackson MJ (2011) Reactive oxygen species: impact on skeletal muscle. Compr Physiol 1(2):941\u2013969. https:\/\/doi.org\/10.1002\/cphy.c100054","journal-title":"Compr Physiol"},{"issue":"3","key":"2943_CR66","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1080\/19390211.2018.1515142","volume":"17","author":"MJ McAllister","year":"2020","unstructured":"McAllister MJ, Basham SA, Waldman HS, Smith JW, Butawan MB, Bloomer RJ (2020) Effects of curcumin on the oxidative stress response to a dual stress challenge in trained men. J Diet Suppl 17(3):261\u2013272. https:\/\/doi.org\/10.1080\/19390211.2018.1515142","journal-title":"J Diet Suppl"},{"key":"2943_CR67","first-page":"75","volume":"10","author":"L Hirose","year":"2004","unstructured":"Hirose L, Nosaka K, Newton M, Laveder A, Kano M, Peake J, Suzuki K (2004) Changes in inflammatory mediators following eccentric exercise of the elbow flexors. Exerc Immunol Rev 10:75\u201390","journal-title":"Exerc Immunol Rev"},{"key":"2943_CR68","doi-asserted-by":"publisher","first-page":"13595","DOI":"10.1038\/srep13595","volume":"5","author":"Y Ma","year":"2015","unstructured":"Ma Y, Zhao S, Shen S, Fang S, Ye Z, Shi Z, Hong A (2015) A novel recombinant slow-release TNF \u03b1-derived peptide effectively inhibits tumor growth and angiogensis. Sci Rep 5:13595. https:\/\/doi.org\/10.1038\/srep13595","journal-title":"Sci Rep"},{"issue":"2","key":"2943_CR69","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1152\/japplphysiol.00130.2004","volume":"98","author":"L Rosendal","year":"2005","unstructured":"Rosendal L, S\u00f8gaard K, Kjaer M, Sj\u00f8gaard G, Langberg H, Kristiansen J (2005) Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise. J Appl Physiol (1985) 98(2):477\u2013481. https:\/\/doi.org\/10.1152\/japplphysiol.00130.2004","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"2943_CR70","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1550-2783-11-31","volume":"11","author":"F Drobnic","year":"2014","unstructured":"Drobnic F, Riera J, Appendino G, Togni S, Franceschi F, Valle X, Pons A, Tur J (2014) Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva\u00ae): a randomised, placebo-controlled trial. J Int Soc Sports Nutr 11(1):31. https:\/\/doi.org\/10.1186\/1550-2783-11-31","journal-title":"J Int Soc Sports Nutr"},{"issue":"2","key":"2943_CR71","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1152\/japplphysiol.00572.2007","volume":"104","author":"MP Miles","year":"2008","unstructured":"Miles MP, Andring JM, Pearson SD, Gordon LK, Kasper C, Depner CM, Kidd JR (2008) Diurnal variation, response to eccentric exercise, and association of inflammatory mediators with muscle damage variables. J Appl Physiol (1985) 104(2):451\u2013458. https:\/\/doi.org\/10.1152\/japplphysiol.00572.2007","journal-title":"J Appl Physiol (1985)"},{"key":"2943_CR72","doi-asserted-by":"publisher","first-page":"5793817","DOI":"10.1155\/2020\/5793817","volume":"2020","author":"MJ Tavassolifar","year":"2020","unstructured":"Tavassolifar MJ, Vodjgani M, Salehi Z, Izad M (2020) The influence of reactive oxygen species in the immune system and pathogenesis of multiple sclerosis. Autoimmune Dis 2020:5793817. https:\/\/doi.org\/10.1155\/2020\/5793817","journal-title":"Autoimmune Dis"},{"issue":"6","key":"2943_CR73","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1055\/s-0028-1112144","volume":"30","author":"N Hattori","year":"2009","unstructured":"Hattori N, Hayashi T, Nakachi K, Ichikawa H, Goto C, Tokudome Y, Kuriki K, Hoshino H, Shibata K, Yamada N, Tokudome M, Suzuki S, Nagaya T, Kobayashi M, Tokudome S (2009) Changes of ROS during a two-day ultra-marathon race. Int J Sports Med 30(6):426\u2013429. https:\/\/doi.org\/10.1055\/s-0028-1112144","journal-title":"Int J Sports Med"},{"issue":"5","key":"2943_CR74","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.freeradbiomed.2010.12.009","volume":"51","author":"SK Powers","year":"2011","unstructured":"Powers SK, Nelson WB, Hudson MB (2011) Exercise-induced oxidative stress in humans: cause and consequences. Free Radic Biol Med 51(5):942\u2013950. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.12.009","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"2943_CR75","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.bcp.2012.07.022","volume":"84","author":"F Caputo","year":"2012","unstructured":"Caputo F, Vegliante R, Ghibelli L (2012) Redox modulation of the DNA damage response. Biochem Pharmacol 84(10):1292\u20131306. https:\/\/doi.org\/10.1016\/j.bcp.2012.07.022","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"2943_CR76","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1249\/MSS.0b013e3181f1ef48","volume":"43","author":"AH Goldfarb","year":"2011","unstructured":"Goldfarb AH, Garten RS, Cho C, Chee PD, Chambers LA (2011) Effects of a fruit\/berry\/vegetable supplement on muscle function and oxidative stress. Med Sci Sports Exerc 43(3):501\u2013508. https:\/\/doi.org\/10.1249\/MSS.0b013e3181f1ef48","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"2943_CR77","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1152\/japplphysiol.00953.2007","volume":"104","author":"LF Ferreira","year":"2008","unstructured":"Ferreira LF, Reid MB (2008) Muscle-derived ROS and thiol regulation in muscle fatigue. J Appl Physiol (1985) 104(3):853\u2013860. https:\/\/doi.org\/10.1152\/japplphysiol.00953.2007","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"2943_CR78","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1249\/00005768-198315010-00010","volume":"15","author":"JA Schwane","year":"1983","unstructured":"Schwane JA, Johnson SR, Vandenakker CB, Armstrong RB (1983) Delayed-onset muscular soreness and plasma CPK and LDH activities after downhill running. Med Sci Sports Exerc 15(1):51\u201356","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"2943_CR79","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1055\/s-2003-37197","volume":"24","author":"DS Willoughby","year":"2003","unstructured":"Willoughby DS, McFarlin B, Bois C (2003) Interleukin-6 expression after repeated bouts of eccentric exercise. Int J Sports Med 24(1):15\u201321. https:\/\/doi.org\/10.1055\/s-2003-37197","journal-title":"Int J Sports Med"},{"issue":"6 Pt 2","key":"2943_CR80","doi-asserted-by":"publisher","first-page":"R1214","DOI":"10.1152\/ajpregu.1990.259.6.R1214","volume":"259","author":"JG Cannon","year":"1990","unstructured":"Cannon JG, Orencole SF, Fielding RA, Meydani M, Meydani SN, Fiatarone MA, Blumberg JB, Evans WJ (1990) Acute phase response in exercise: interaction of age and vitamin E on neutrophils and muscle enzyme release. Am J Physiol 259(6 Pt 2):R1214-1219. https:\/\/doi.org\/10.1152\/ajpregu.1990.259.6.R1214","journal-title":"Am J Physiol"},{"issue":"3","key":"2943_CR81","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3109\/10715762.2010.532493","volume":"45","author":"U Singh","year":"2011","unstructured":"Singh U, Barik A, Singh BG, Priyadarsini KI (2011) Reactions of reactive oxygen species (ROS) with curcumin analogues: structure-activity relationship. Free Radic Res 45(3):317\u2013325. https:\/\/doi.org\/10.3109\/10715762.2010.532493","journal-title":"Free Radic Res"},{"key":"2943_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arr.2016.08.006","volume":"31","author":"P Soysal","year":"2016","unstructured":"Soysal P, Stubbs B, Lucato P, Luchini C, Solmi M, Peluso R, Sergi G, Isik AT, Manzato E, Maggi S, Maggio M, Prina AM, Cosco TD, Wu Y-T, Veronese N (2016) Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Res Rev 31:1\u20138. https:\/\/doi.org\/10.1016\/j.arr.2016.08.006","journal-title":"Ageing Res Rev"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-022-02943-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-022-02943-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-022-02943-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:13:42Z","timestamp":1666743222000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-022-02943-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,13]]},"references-count":82,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2943"],"URL":"https:\/\/doi.org\/10.1007\/s00394-022-02943-7","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,13]]},"assertion":[{"value":"29 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Krutika Nanavati, Ajmol Ali, Kay Rutherfurd-Markwick, Sung Je Lee and Nicolette Bishop declare that they have no conflicts of interest relevant to the content of this review.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}