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We investigated whether plasma SAAs (methionine, total cysteine (tCys), total homocysteine, cystathionine and total glutathione) are related to specific fat depots.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Methods<\/jats:title>\n              <jats:p>We examined cross-sectional subsets from the CODAM cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009470, 61.3% men, median [IQR]: 67 [61, 71] years) and The Maastricht Study (DMS; <jats:italic>n<\/jats:italic>\u2009=\u2009371, 53.4% men, 63 [55, 68] years), enriched with (pre)diabetic individuals. SAAs were measured in fasting EDTA plasma with LC\u2013MS\/MS. Outcomes comprised BMI, skinfolds, waist circumference (WC), dual-energy X-ray absorptiometry (DXA, DMS), body composition, abdominal subcutaneous and visceral adipose tissues (CODAM: ultrasound, DMS: MRI) and liver fat (estimated, in CODAM, or MRI-derived, in DMS, liver fat percentage and fatty liver disease). Associations were examined with linear or logistic regressions adjusted for relevant confounders with z-standardized primary exposures and outcomes.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Results<\/jats:title>\n              <jats:p>Methionine was associated with all measures of liver fat, e.g<jats:italic>.,<\/jats:italic> fatty liver disease [CODAM: OR\u2009=\u20091.49 (95% CI 1.19, 1.88); DMS: OR\u2009=\u20091.51 (1.09, 2.14)], but not with other fat depots. tCys was associated with overall obesity, e.g., BMI [CODAM: <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.19 (0.09, 0.28); DMS: <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.24 (0.14, 0.34)]; peripheral adiposity, e.g., biceps and triceps skinfolds [CODAM: <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.15 (0.08, 0.23); DMS: <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.20 (0.12, 0.29)]; and central adiposity, e.g., WC [CODAM: <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.16 (0.08, 0.25); DMS: <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.17 (0.08, 0.27)]. Associations of tCys with VAT and liver fat were inconsistent. Other SAAs were not associated with body fat.<\/jats:p>\n            <\/jats:sec><jats:sec>\n              <jats:title>Conclusion<\/jats:title>\n              <jats:p>Plasma concentrations of methionine and tCys showed distinct associations with different fat depots, with similar strengths in the two cohorts.<\/jats:p>\n            <\/jats:sec>","DOI":"10.1007\/s00394-022-03041-4","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T08:03:03Z","timestamp":1667376183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9218-3849","authenticated-orcid":false,"given":"Elena C.","family":"Tore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8624-860X","authenticated-orcid":false,"given":"Amany K.","family":"Elshorbagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2327-4712","authenticated-orcid":false,"given":"Frans C. 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