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However, there is no consensus about the effects of dietary NO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> or beetroot (BR) juice supplementation on cognitive function.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The aim of this study was to evaluate the effects of a single dose of a chewable BR-based supplement on cognitive performance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A double-blind randomized placebo-controlled two-period crossover clinical trial was carried out based on the extension of the CONSORT guidelines for randomized crossover trials. A total of 44 participants (24\u00a0F; 20\u00a0M; 32.7 [12.5] years; 66.3 [9.0] kg; 170 [9.2] cm; 22.8 [1.4] kg\/m<jats:sup>2<\/jats:sup>) were randomly allocated to receive first either four BR-based chewable tablets (BR-CT) containing 3\u00a0g of a <jats:italic>Beta vulgaris<\/jats:italic> extract (RedNite<jats:sup>\u00ae<\/jats:sup>) or four tablets of a placebo (maltodextrin). A 4-day washout period was used before crossover. Ninety minutes after ingestion of the treatments, a neuropsychological testing battery was administered in each period. The trial was registered at clinicaltrials.gov NCT05509075.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Significant improvements with moderate effect size were found on memory consolidation at the short and long term only after BR-CT supplementation via the Rey Auditory Verbal Learning Test immediate (+\u200920.69%) and delayed (+\u200912.34%) recalls. Likewise, enhancement on both frontal lobe functions (+\u20092.57%) and cognitive flexibility (+\u200911.16%) were detected after BR-CT. There was no significant change (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) on verbal memory of short-term digits, working memory and information processing speed. Mixed results were found on mood and anxiety through the Beck Depression Inventory-II (BDI-II) and the State-Trait Anxiety Inventory (STAI-Y1 and STAI-Y2); however, sequence and period effects were seen on STAI-Y2.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The acute administration of a chewable BR-based supplement improves certain aspects of cognitive function in healthy females and males, particularly memory capacity and frontal skills.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00394-023-03265-y","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T16:02:29Z","timestamp":1698163349000},"page":"303-321","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Acute effects of a chewable beetroot-based supplement on cognitive performance: a double-blind randomized placebo-controlled crossover clinical trial"],"prefix":"10.1007","volume":"63","author":[{"given":"Maria Grazia","family":"Vaccaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo","family":"Innocenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Cione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Gallelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovambattista","family":"De Sarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A.","family":"Bonilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1668-7690","authenticated-orcid":false,"given":"Roberto","family":"Cannataro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"issue":"1","key":"3265_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cmet.2018.06.007","volume":"28","author":"JO Lundberg","year":"2018","unstructured":"Lundberg JO, Carlstrom M, Weitzberg E (2018) Metabolic effects of dietary nitrate in health and disease. 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