{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:21:20Z","timestamp":1786980080033,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s00394-023-03292-9","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T11:03:58Z","timestamp":1704193438000},"page":"777-784","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of a prebiotic formulation on the composition of the faecal microbiota of people with functional constipation"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-135X","authenticated-orcid":false,"given":"Rene","family":"Erhardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Steels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna E.","family":"Harnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Wong","family":"Taing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Steadman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"issue":"2","key":"3292_CR1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.5694\/mja18.00241","volume":"209","author":"CJ Black","year":"2018","unstructured":"Black CJ, Ford AC (2018) Chronic idiopathic constipation in adults: epidemiology, pathophysiology, diagnosis and clinical management. Med J Aust 209(2):86\u201391","journal-title":"Med J Aust"},{"key":"3292_CR2","unstructured":"The Rome Foundation (2016) Rome IV criteria. https:\/\/theromefoundation.org\/rome-iv\/rome-iv-criteria\/. Accessed 02\/04\/2022 2022"},{"issue":"7164","key":"3292_CR3","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/nature06244","volume":"449","author":"PJ Turnbaugh","year":"2007","unstructured":"Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI (2007) The human microbiome project. Nature 449(7164):804\u2013810. https:\/\/doi.org\/10.1038\/nature06244","journal-title":"Nature"},{"issue":"1","key":"3292_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13073-016-0307-y","volume":"8","author":"J Lloyd-Price","year":"2016","unstructured":"Lloyd-Price J, AbuAli G, Huttenhower C (2016) The healthy human microbiome. Genome Med 8(1):51. https:\/\/doi.org\/10.1186\/s13073-016-0307-y","journal-title":"Genome Med"},{"issue":"1","key":"3292_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1136\/gutjnl-2015-309618","volume":"65","author":"D Vandeputte","year":"2016","unstructured":"Vandeputte D, Falony G, Vieira-Silva S, Tito RY, Joossens M, Raes J (2016) Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates. Gut 65(1):57\u201362. https:\/\/doi.org\/10.1136\/gutjnl-2015-309618","journal-title":"Gut"},{"issue":"8","key":"3292_CR6","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","volume":"14","author":"GR Gibson","year":"2017","unstructured":"Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G (2017) Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14(8):491\u2013502. https:\/\/doi.org\/10.1038\/nrgastro.2017.75","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"3292_CR7","unstructured":"British Nutrition Foundation (2022) The science of fibre. https:\/\/www.nutrition.org.uk\/healthy-sustainable-diets\/starchy-foods-sugar-and-fibre\/fibre\/?level=Health%20professional. Accessed May 07 2022"},{"key":"3292_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/nu14010137","author":"D Plamada","year":"2021","unstructured":"Plamada D, Vodnar DC (2021) Polyphenols-gut microbiota interrelationship: a transition to a new generation of prebiotics. Nutrients. https:\/\/doi.org\/10.3390\/nu14010137","journal-title":"Nutrients"},{"issue":"7","key":"3292_CR9","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1097\/MCG.0000000000000723","volume":"51","author":"F Azpiroz","year":"2017","unstructured":"Azpiroz F, Molne L, Mendez S, Nieto A, Manichanh C, Mego M, Accarino A, Santos J, Sailer M, Theis S, Guarner F (2017) Effect of chicory-derived inulin on abdominal sensations and bowel motor function. J Clin Gastroenterol 51(7):619\u2013625. https:\/\/doi.org\/10.1097\/MCG.0000000000000723","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"3292_CR10","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1039\/c0fo00101e","volume":"2","author":"J Slavin","year":"2011","unstructured":"Slavin J, Feirtag J (2011) Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects. Food Funct 2(1):72\u201377. https:\/\/doi.org\/10.1039\/c0fo00101e","journal-title":"Food Funct"},{"issue":"2","key":"3292_CR11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.12938\/bmfh.18-013","volume":"38","author":"Y Sakai","year":"2019","unstructured":"Sakai Y, Seki N, Hamano H, Ochi H, Abe F, Shimizu F, Masuda K, Iino H (2019) A study of the prebiotic effect of lactulose at low dosages in healthy Japanese women. Biosci Microbiota Food Health 38(2):69\u201372","journal-title":"Biosci Microbiota Food Health"},{"issue":"10","key":"3292_CR12","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1017\/S0007114511004697","volume":"107","author":"GE Walton","year":"2012","unstructured":"Walton GE, van den Heuvel EG, Kosters MH, Rastall RA, Tuohy KM, Gibson GR (2012) A randomised crossover study investigating the effects of galacto-oligosaccharides on the faecal microbiota in men and women over 50 years of age. Brit J Nutr 107(10):1466\u20131475. https:\/\/doi.org\/10.1017\/S0007114511004697","journal-title":"Brit J Nutr"},{"issue":"6","key":"3292_CR13","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1017\/S0007114522003853","volume":"130","author":"R Erhardt","year":"2023","unstructured":"Erhardt R, Harnett JE, Steels E, Steadman KJ (2023) Functional constipation and the effect of prebiotics on the gut microbiota: a review. Br J Nutr 130(6):1015\u20131023. https:\/\/doi.org\/10.1017\/S0007114522003853","journal-title":"Br J Nutr"},{"issue":"2","key":"3292_CR14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.aimed.2023.05.001","volume":"10","author":"E Steels","year":"2023","unstructured":"Steels E, Erhardt R, Harnett JE, Vigar V, Steadman KJ (2023) Efficacy of a prebiotic formulation for treatment of functional constipation and associated gastrointestinal symptoms in adults: a randomised controlled trial. AIMED 10(2):43\u201350. https:\/\/doi.org\/10.1016\/j.aimed.2023.05.001","journal-title":"AIMED"},{"issue":"1","key":"3292_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s43705-021-00014-2","volume":"1","author":"AL Pribyl","year":"2021","unstructured":"Pribyl AL, Parks DH, Angel NZ, Boyd JA, Hasson AG, Fang L, MacDonald SL, Wills BA, Wood DLA, Krause L, Tyson GW, Hugenholtz P (2021) Critical evaluation of faecal microbiome preservation using metagenomic analysis. ISME Commun 1(1):s43705-43021-00014-43702. https:\/\/doi.org\/10.1038\/s43705-021-00014-2","journal-title":"ISME Commun"},{"key":"3292_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.643682","volume":"12","author":"DH Parks","year":"2021","unstructured":"Parks DH, Rigato F, Vera-Wolf P, Krause L, Hugenholtz P, Tyson GW, Wood DLA (2021) Evaluation of the Microba community profiler for taxonomic profiling of metagenomic datasets from the human gut microbiome. Front Microbiol 12:643682. https:\/\/doi.org\/10.3389\/fmicb.2021.643682","journal-title":"Front Microbiol"},{"key":"3292_CR17","unstructured":"GTDB (2022) Genome Taxonomy DataBase,. Australian Centre for Ecogenomics. https:\/\/gtdb.ecogenomic.org\/. 2022"},{"key":"3292_CR18","unstructured":"Uni Prot (2022) Uni Ref. Uniprot consortium. https:\/\/www.uniprot.org\/help\/uniref. Accessed Sep 28 2022"},{"issue":"25","key":"3292_CR19","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/455481a","volume":"455","author":"F Hugenholtz","year":"2008","unstructured":"Hugenholtz F, Tyson G (2008) Metagenomics. Nature 455(25):481\u2013483","journal-title":"Nature"},{"key":"3292_CR20","unstructured":"Food Works (2022) Foodworks 10 Professional. Xyris. https:\/\/xyris.com.au\/products\/foodworks-10-professional\/. Accessed Oct 22 2022"},{"key":"3292_CR21","unstructured":"Statology (2022) Shannon diversity index. Statology. https:\/\/www.statology.org\/shannon-diversity-index\/. Accessed Oct 14 2022"},{"key":"3292_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0300-6","volume-title":"Linear mixed models for longitudinal data","author":"G Molenberghs","year":"2000","unstructured":"Molenberghs G, Verbeke G (2000) Linear mixed models for longitudinal data. Springer, New York. https:\/\/doi.org\/10.1007\/978-1-4419-0300-6"},{"key":"3292_CR23","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1152\/ajpregu.2000.279.1.R1","volume":"279","author":"D Curran-Everett","year":"2000","unstructured":"Curran-Everett D (2000) Multiple comparisons: philosophies and illustrations. Am J Physiol Regulatory Integrative Comp Physiol 279:R1\u2013R8","journal-title":"Am J Physiol Regulatory Integrative Comp Physiol"},{"key":"3292_CR24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.foodres.2018.07.043","volume":"115","author":"NB Danneskiold-Samsoe","year":"2019","unstructured":"Danneskiold-Samsoe NB, de Freitas D, Queiroz Barros H, Santos R, Bicas JL, Cazarin CBB, Madsen L, Kristiansen K, Pastore GM, Brix S, Marostica Junior MR (2019) Interplay between food and gut microbiota in health and disease. Food Res Int 115:23\u201331. https:\/\/doi.org\/10.1016\/j.foodres.2018.07.043","journal-title":"Food Res Int"},{"issue":"7","key":"3292_CR25","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1136\/gutjnl-2019-319654","volume":"69","author":"TS Ghosh","year":"2020","unstructured":"Ghosh TS, Rampelli S, Jeffery IB, Santoro A, Neto M, Capri M, Giampieri E, Jennings A, Candela M, Turroni S, Zoetendal EG, Hermes GDA, Elodie C, Meunier N, Brugere CM, Pujos-Guillot E, Berendsen AM, De Groot L, Feskins EJM, Kaluza J, Pietruszka B, Bielak MJ, Comte B, Maijo-Ferre M, Nicoletti C, De Vos WM, Fairweather-Tait S, Cassidy A, Brigidi P, Franceschi C, O\u2019Toole PW (2020) Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries. Gut 69(7):1218\u20131228. https:\/\/doi.org\/10.1136\/gutjnl-2019-319654","journal-title":"Gut"},{"issue":"4","key":"3292_CR26","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1089\/omi.2018.0013","volume":"22","author":"I Laudadio","year":"2018","unstructured":"Laudadio I, Fulci V, Palone F, Stronati L, Cucchiara S, Carissimi C (2018) Quantitative assessment of shotgun metagenomics and 16S rDNA amplicon sequencing in the study of human gut microbiome. OMICS 22(4):248\u2013254. https:\/\/doi.org\/10.1089\/omi.2018.0013","journal-title":"OMICS"},{"issue":"9","key":"3292_CR27","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1136\/gutjnl-2020-323877","volume":"70","author":"F Asnicar","year":"2021","unstructured":"Asnicar F, Leeming ER, Dimidi E, Mazidi M, Franks PW, Al Khatib H, Valdes AM, Davies R, Bakker E, Francis L, Chan A, Gibson R, Hadjigeorgiou G, Wolf J, Spector TD, Segata N, Berry SE (2021) Blue poo: impact of gut transit time on the gut microbiome using a novel marker. Gut 70(9):1665\u20131674. https:\/\/doi.org\/10.1136\/gutjnl-2020-323877","journal-title":"Gut"},{"issue":"4","key":"3292_CR28","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nm.4517","volume":"24","author":"JA Gilbert","year":"2018","unstructured":"Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R (2018) Current understanding of the human microbiome. Nat Med 24(4):392\u2013400. https:\/\/doi.org\/10.1038\/nm.4517","journal-title":"Nat Med"},{"issue":"Suppl","key":"3292_CR29","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1017\/S0007114514004127","volume":"113","author":"Z Xu","year":"2015","unstructured":"Xu Z, Knight R (2015) Dietary effects on human gut microbiome diversity. Brit J Nutr 113(Suppl):S1-5. https:\/\/doi.org\/10.1017\/S0007114514004127","journal-title":"Brit J Nutr"},{"issue":"1","key":"3292_CR30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12967-017-1175-y","volume":"15","author":"RK Singh","year":"2017","unstructured":"Singh RK, Chang HW, Yan D, Lee KM, Ucmak D, Wong K, Abrouk M, Farahnik B, Nakamura M, Zhu TH, Bhutani T, Liao W (2017) Influence of diet on the gut microbiome and implications for human health. J Transl Med 15(1):73. https:\/\/doi.org\/10.1186\/s12967-017-1175-y","journal-title":"J Transl Med"},{"issue":"1","key":"3292_CR31","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s40168-020-00856-3","volume":"8","author":"GCA Amos","year":"2020","unstructured":"Amos GCA, Logan A, Anwar S, Fritzsche M, Mate R, Bleazard T, Rijpkema S (2020) Developing standards for the microbiome field. Microbiome 8(1):98. https:\/\/doi.org\/10.1186\/s40168-020-00856-3","journal-title":"Microbiome"},{"key":"3292_CR32","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65088","volume":"10","author":"F Beghini","year":"2021","unstructured":"Beghini F, McIver LJ, Blanco-Miguez A, Dubois L, Asnicar F, Maharjan S, Mailyan A, Manghi P, Scholz M, Thomas AM, Valles-Colomer M, Weingart G, Zhang Y, Zolfo M, Huttenhower C, Franzosa EA, Segata N (2021) Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3. Elife 10:eLife.65088. https:\/\/doi.org\/10.7554\/eLife.65088","journal-title":"Elife"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-023-03292-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-023-03292-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-023-03292-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T02:05:24Z","timestamp":1710727524000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-023-03292-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,2]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["3292"],"URL":"https:\/\/doi.org\/10.1007\/s00394-023-03292-9","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,2]]},"assertion":[{"value":"10 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and the guidelines of the National Health and Medical Research Council of Australia. Ethics approval was obtained from the National Institute of Integrative Medicine, Human Research Ethics Committee (approval number 0075E_2020) and ratified by the Office of Research Ethics of The University of Queensland (2020002481 \/ 0074E_2020). The trial was registered with the Australia New Zealand Clinical Trials Registry, ACTRN12620001247965.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}