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Cognitive performance was evaluated using a neurophysiological test battery (CANTAB) and CBF was measured using magnetic resonance imaging perfusion method Arterial Spin Labeling (ASL). Serum samples were collected to determine brain-derived neurotrophic factor (BDNF) concentrations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Anthropometrics, and energy and nutrient intakes remained stable throughout the trial. NWT-03 was well tolerated, and compliance was excellent (median: 99%; range: 87\u2013103%). No overall intervention effects were observed on cognitive performance or CBF, but post-hoc analyses revealed significant improvements on executive function in women, but not men. Specifically, a reduction of 74\u00a0ms in reaction latency on the multitasking task (95% CI: \u2212134 to \u221215; <jats:italic>p<\/jats:italic>\u2009=\u20090.02), a reduction of 9 between errors (95%CI: \u221214 to \u22123; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and a reduction of 9 total errors (95%CI: \u221215 to \u22123; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) on the spatial working memory task were found in women. No intervention effects were observed on serum BDNF concentrations (<jats:italic>p<\/jats:italic>\u2009=\u20090.31).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Long-term consumption of NWT-03 improved multitasking abilities and working memory in women with elevated SCF. Brain vascular function remained unaffected. Sex differences in executive function require additional clarification.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00394-024-03394-y","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T12:01:47Z","timestamp":1714824107000},"page":"2095-2107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Long-term effects of an egg-protein hydrolysate on cognitive performance and brain vascular function: a double-blind randomized controlled trial in adults with elevated subjective cognitive failures"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9749-0404","authenticated-orcid":false,"given":"Micah S.","family":"Adams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8908-3580","authenticated-orcid":false,"given":"Ronald P.","family":"Mensink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1570-9608","authenticated-orcid":false,"given":"Jogchum","family":"Plat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-5776","authenticated-orcid":false,"given":"Peter J.","family":"Joris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"3394_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.2044-8260.1982.tb01421.x","volume":"21","author":"DE Broadbent","year":"1982","unstructured":"Broadbent DE, Cooper PF, FizGerald P et al (1982) The Cognitive Failures Questionnaire (CFQ) and its correlates. 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