{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:17:30Z","timestamp":1774261050701,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100013955","name":"Astellas Pharma, Netherlands","doi-asserted-by":"publisher","award":["TransplantLines Biobank"],"award-info":[{"award-number":["TransplantLines Biobank"]}],"id":[{"id":"10.13039\/501100013955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013955","name":"Astellas Pharma, Netherlands","doi-asserted-by":"publisher","award":["Cohort study"],"award-info":[{"award-number":["Cohort study"]}],"id":[{"id":"10.13039\/501100013955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020068","name":"Topconsortium voor Kennis en Innovatie","doi-asserted-by":"publisher","award":["PPP-2019-032"],"award-info":[{"award-number":["PPP-2019-032"]}],"id":[{"id":"10.13039\/501100020068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020068","name":"Topconsortium voor Kennis en Innovatie","doi-asserted-by":"publisher","award":["PPP-2022-015"],"award-info":[{"award-number":["PPP-2022-015"]}],"id":[{"id":"10.13039\/501100020068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007560","name":"Chiesi Farmaceutici","doi-asserted-by":"publisher","award":["PA-SP\/PRJ-2020-9136"],"award-info":[{"award-number":["PA-SP\/PRJ-2020-9136"]}],"id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["14939"],"award-info":[{"award-number":["14939"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Vitamin C deficiency is associated with excess mortality in kidney transplant recipients (KTR). We aim to evaluate plasma vitamin C status at different post-transplantation moments and assess the main characteristics associated with vitamin C deficiency in KTR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Plasma vitamin C was assessed in 598 KTR at 3-, 6-, 12-, 24-, and 60-months post-transplantation, 374 late KTR with a functioning graft\u2009\u2265\u20091\u00a0year, and 395 potential donors. Vitamin C deficiency was defined as plasma vitamin C\u2009\u2264\u200928\u00a0\u00b5mol\/L. Diet was assessed by a 177-item food frequency questionnaire. Data on vitamin C-containing supplements use were extracted from patient records and verified\u00a0with the patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Vitamin C deficiency ranged from 46% (6-months post-transplantation) to 30% (\u2265\u20091\u00a0year post-transplantation). At all time points, KTR had lower plasma vitamin C than potential donors (30\u201341 \u00b5mol\/L vs 58\u00a0\u00b5mol\/L). In cross-sectional analyses of the 953 KTR at their first visit\u2009\u2265\u200912\u00a0months after transplantation (55\u2009\u00b1\u200914\u00a0years, 62% male, eGFR 55\u2009\u00b1\u200919\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup>), the characteristics with the strongest association with vitamin C deficiency were diabetes and smoking (OR 2.67 [95% CI 1.84\u20133.87] and OR 1.84 [95% CI 1.16\u20132.91], respectively). Dietary vitamin C intake and vitamin C supplementation were associated with lower odds (OR per 100\u00a0mg\/day 0.38, 95% CI 0.24\u20130.61 and OR 0.21, 95% CI 0.09\u20130.44, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Vitamin C deficiency is frequent among KTR regardless of the time after transplantation, especially among those with diabetes and active smokers. The prevalence of vitamin C deficiency was lower among KTR with higher vitamin C intake, both dietary and supplemented. Further research is warranted to assess whether correcting this modifiable risk factor could improve survival in KTR.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00394-024-03426-7","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T16:02:27Z","timestamp":1716998547000},"page":"2357-2366","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin C deficiency after kidney transplantation: a cohort and cross-sectional study of the TransplantLines biobank"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4693-5974","authenticated-orcid":false,"given":"Manuela","family":"Yepes-Calder\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"van der Veen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Mart\u00edn del Campo S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daan","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo G.","family":"Sotomayor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim J.","family":"Knobbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel J.","family":"Vos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Corpeleijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin H.","family":"de Borst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan J. 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