{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:01:47Z","timestamp":1791583307623,"version":"4.3.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s00394-024-03520-w","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T07:30:15Z","timestamp":1732779015000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The probiotic Lactobacillus plantarum alleviates colitis by modulating gut microflora to activate PPAR\u03b3 and inhibit MAPKs\/NF-\u03baB"],"prefix":"10.1007","volume":"64","author":[{"given":"Rongxin","family":"Zang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaodong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"issue":"7152","key":"3520_CR1","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature06005","volume":"448","author":"RJ Xavier","year":"2007","unstructured":"Xavier RJ, Podolsky DK (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature 448(7152):427\u2013434. https:\/\/doi.org\/10.1038\/nature06005. PubMed PMID: WOS:000248302700038","journal-title":"Nature"},{"key":"3520_CR2","doi-asserted-by":"publisher","DOI":"10.1039\/d3fo05583c","author":"CY Mo","year":"2024","unstructured":"Mo CY, Liu RF, Yang ZH, Ma AM (2024) Polysaccharide from mycelium improves DSS-induced colitis in mice by regulating inflammatory cytokines, oxidative stress and gut microbiota. Food Funct. https:\/\/doi.org\/10.1039\/d3fo05583c. PubMed PMID: WOS:001185736000001","journal-title":"Food Funct"},{"issue":"2","key":"3520_CR3","doi-asserted-by":"publisher","first-page":"709","DOI":"10.26599\/FSHW.2022.9250060","volume":"13","author":"BY Mao","year":"2024","unstructured":"Mao BY, Guo WL, Cui SM, Zhang QX, Zhao JX, Tang X, et al. displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice. Food Sci Hum Well. 2024;13(2):709\u2009\u2212\u200920. https:\/\/doi.org\/10.26599\/Fshw.2022.9250060. PubMed PMID: WOS:001097179300004.","journal-title":"Food Sci Hum Well"},{"issue":"8","key":"3520_CR4","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.bbadis.2011.04.005","volume":"1812","author":"RM Gadaleta","year":"2011","unstructured":"Gadaleta RM, Oldenburg B, Willemsen ECL, Spit M, Murzilli S, Salvatore L et al (2011) Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-\u03baB signaling in the intestine. Bba-Mol Basis Dis 1812(8):851\u2013858. https:\/\/doi.org\/10.1016\/j.bbadis.2011.04.005. PubMed PMID: WOS:000292350400007","journal-title":"Bba-Mol Basis Dis"},{"key":"3520_CR5","doi-asserted-by":"publisher","unstructured":"Marchiano S, Biagioli M, Roselli R, Zampella A, Di Giorgio C, Bordoni M et al (2022) Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1\/FXR signaling. Bba-Mol Cell Biol L. 1867(11). doi: ARTN 159218 https:\/\/doi.org\/10.1016\/j.bbalip.2022.159218. PubMed PMID: WOS:000861090000001","DOI":"10.1016\/j.bbalip.2022.159218"},{"key":"3520_CR6","doi-asserted-by":"publisher","unstructured":"Chen Q, Mei CX, Guo M, Wang BT, Chen HQ, Zhao JX et al (2024) CCFM1180 attenuates obesity induced by estrogen deficiency by activating estrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites. Food Sci Hum Well 13(2):765\u2013777 https:\/\/doi.org\/10.26599\/Fshw.2022.9250065. PubMed PMID: WOS:001097179300009","DOI":"10.26599\/Fshw.2022.9250065"},{"key":"3520_CR7","doi-asserted-by":"publisher","unstructured":"Li ZL, Guo Q, Lin FQ, Li CT, Yan L, Zhou HO et al (2024) Lactobacillus plantarum supernatant inhibits growth of Riemerella anatipestifer and mediates intestinal antimicrobial defense in Muscovy ducks. Poult Sci 103(2). https:\/\/doi.org\/10.1016\/j.psj.2023.103216. PubMed PMID: WOS:001134457300001","DOI":"10.1016\/j.psj.2023.103216"},{"issue":"4","key":"3520_CR8","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1556\/066.2023.00174","volume":"52","author":"MW Wang","year":"2023","unstructured":"Wang MW, She F, Song J, Liu YQ, Long XY, Zhao X et al (2023) Preventive effect of Lactobacillus plantarum YS1 isolated from naturally fermented yoghurt on carrageenan-induced thrombosis in mice. Acta Aliment Hung 52(4):623\u2013635 PubMed PMID: WOS:001124999300013","journal-title":"Acta Aliment Hung"},{"key":"3520_CR9","doi-asserted-by":"publisher","unstructured":"Quagebeur R, Dalile B, Raes J, Van Oudenhove L, Verbeke K, Vrieze E (2023) The role of short-chain fatty acids (SCFAs) in regulating stress responses, eating behavior, and nutritional state in anorexia nervosa: protocol for a randomized controlled trial. J Eat Disord. 11(1). doi: ARTN 191 https:\/\/doi.org\/10.1186\/s40337-023-00917-6. PubMed PMID: WOS:001088062700002","DOI":"10.1186\/s40337-023-00917-6"},{"key":"3520_CR10","doi-asserted-by":"publisher","unstructured":"Zhou R, Wang LY, Li YD, Wu HH, Lu LP, Zang RX et al (2024) Effects of tail Vegetable Fermented feed on the growth and Rumen Microbiota of lambs. Animals-Basel. 14(2). doi: ARTN 303 https:\/\/doi.org\/10.3390\/ani14020303. PubMed PMID: WOS:001151701700001.","DOI":"10.3390\/ani14020303"},{"issue":"3","key":"3520_CR11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000490864","volume":"34","author":"IBD Insight APP Explaining","year":"2018","unstructured":"IBD Insight APP Explaining (2018) Chronic-inflammatory bowel disease in patient interview. Visc Med 34(3):231 PubMed PMID: WOS:000437399400015","journal-title":"Visc Med"},{"key":"3520_CR12","doi-asserted-by":"publisher","DOI":"10.1039\/d3fo04670b","author":"TX Ao","year":"2024","unstructured":"Ao TX, Huang HR, Zheng B, Chen Y, Xie JH, Hu XB et al (2024) Ameliorative effect of bound polyphenols in mung bean coat dietary fiber on DSS-induced ulcerative colitis in mice: the intestinal barrier and intestinal flora. Food Funct. https:\/\/doi.org\/10.1039\/d3fo04670b. PubMed PMID: WOS:001184718400001","journal-title":"Food Funct"},{"key":"3520_CR13","doi-asserted-by":"publisher","unstructured":"Shi RR, Yu FZ, Hu XY, Liu Y, Jin YY, Ren HL et al (2023) Protective effect of subsp. SC-5 on Dextran Sulfate Sodium-Induced Colitis in mice. Foods 12(4). https:\/\/doi.org\/10.3390\/foods12040897. PubMed PMID: WOS:000939554800001","DOI":"10.3390\/foods12040897"},{"key":"3520_CR14","doi-asserted-by":"publisher","unstructured":"Yu FZ, Hu XY, Ren HL, Wang XX, Shi RR, Guo J et al (2024) Protective effect of synbiotic combination of and olive oil extract tyrosol in a murine model of ulcerative colitis. J Transl Med. 22(1). doi: ARTN 308 https:\/\/doi.org\/10.1186\/s12967-024-05026-9. PubMed PMID: WOS:001190989100004","DOI":"10.1186\/s12967-024-05026-9"},{"issue":"6","key":"3520_CR15","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1039\/d4fo90024c","volume":"15","author":"H Li","year":"2024","unstructured":"Li H, Christman LM, Yagiz Y, Washington TL, Wang GP, Gu LW (2024) Dealcoholized muscadine wine was partially effective in preventing and treating dextran sulfate sodium-induced colitis and restoring gut dysbiosis in mice (retraction of 14, Pg 5994, 2023). Food Funct 15(6):3214. https:\/\/doi.org\/10.1039\/d4fo90024c. PubMed PMID: WOS:001178173400001","journal-title":"Food Funct"},{"key":"3520_CR16","doi-asserted-by":"publisher","unstructured":"Phage therapy suppresses gut inflammation in IBD. Nat Biotechnol (2022);40(9):1327-. https:\/\/doi.org\/10.1038\/s41587-022-01477-x. PubMed PMID: WOS:000852896400014","DOI":"10.1038\/s41587-022-01477-x"},{"key":"3520_CR17","doi-asserted-by":"publisher","unstructured":"Kang CS, Ban M, Choi EJ, Moon HG, Jeon JS, Kim DK et al (2013) Extracellular Vesicles Derived from Gut Microbiota, Especially, Protect the Progression of Dextran Sulfate Sodium-Induced Colitis. Plos One. 8(10). doi: ARTN e76520 https:\/\/doi.org\/10.1371\/journal.pone.0076520. PubMed PMID: WOS:000326152300006","DOI":"10.1371\/journal.pone.0076520"},{"key":"3520_CR18","doi-asserted-by":"publisher","unstructured":"Li YX, Lv L, Li SL, Qian HH (2024) Gentianine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibition of TLR4\/NLRP3-mediated pyroptosis. Int Immunopharmacol 126. https:\/\/doi.org\/10.1016\/j.intimp.2023.111214. PubMed PMID: WOS:001121722300001","DOI":"10.1016\/j.intimp.2023.111214"},{"key":"3520_CR19","doi-asserted-by":"publisher","unstructured":"Miao ZW, Chen LP, Feng H, Gu MJ, Yan J, Xu Y et al (2021) Baitouweng Decoction Ameliorates Ulcerative Colitis in Mice Partially Attributed to Regulating Th17\/Treg Balance and Restoring Intestinal Epithelial Barrier. Front Pharmacol. 11. doi: ARTN 531117 https:\/\/doi.org\/10.3389\/fphar.2020.531117. PubMed PMID: WOS:000611184700001","DOI":"10.3389\/fphar.2020.531117"},{"key":"3520_CR20","doi-asserted-by":"publisher","unstructured":"Cao JH, Qin L, Zhang LP, Wang K, Yao MK, Qu CF et al (2024) Protective effect of cellulose and soluble dietary fiber from by-products on regulating inflammatory responses, gut microbiota, and SCFAs production in colitis mice. Int J Biol Macromol 267. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.131214. PubMed PMID: WOS:001226654300001","DOI":"10.1016\/j.ijbiomac.2024.131214"},{"key":"3520_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00871-3","author":"C Danne","year":"2023","unstructured":"Danne C, Skerniskyte J, Marteyn B, Sokol H (2023) Neutrophils: from IBD to the gut microbiota. Nat Rev Gastro Hepat. https:\/\/doi.org\/10.1038\/s41575-023-00871-3. PubMed PMID: WOS:001126844400001","journal-title":"Nat Rev Gastro Hepat"},{"key":"3520_CR22","doi-asserted-by":"publisher","unstructured":"Weidner JIBD (2023) Who Knows Best? Digest Dis Sci. https:\/\/doi.org\/10.1007\/s10620-023-08193-9. PubMed PMID: WOS:001123725000005","DOI":"10.1007\/s10620-023-08193-9"},{"key":"3520_CR23","doi-asserted-by":"publisher","unstructured":"Okada K, Yokota J, Yamashita T, Inui T, Kishimoto W, Nakase H et al (2024) Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study. Drug Metab Pharmacok 54. https:\/\/doi.org\/10.1016\/j.dmpk.2023.100532. PubMed PMID: WOS:001135527000001","DOI":"10.1016\/j.dmpk.2023.100532"},{"issue":"2","key":"3520_CR24","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.ijfoodmicro.2008.09.010","volume":"128","author":"K Hatakka","year":"2008","unstructured":"Hatakka K, Holma R, El-Nezami H, Suomalainen T, Kuisma M, Saxelin M et al (2008) The influence of LC705 together with ssp JS on potentially carcinogenic bacterial activity in human colon. Int J Food Microbiol 128(2):406\u2013410 PubMed PMID: WOS:000261668100032","journal-title":"Int J Food Microbiol"},{"key":"3520_CR25","doi-asserted-by":"publisher","unstructured":"Wang JW, Wu Z, Huang YL, Jin L, Xu JY, Yao ZY et al (2024) IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6-dependent STAT3 pathway. Environ Toxicol. doi: https:\/\/doi.org\/10.1002\/tox.24106. PubMed PMID: WOS:001134726100001.","DOI":"10.1002\/tox.24106"},{"issue":"2","key":"3520_CR26","doi-asserted-by":"publisher","first-page":"698","DOI":"10.26599\/FSHW.2022.9250059","volume":"13","author":"HY Zhang","year":"2024","unstructured":"Zhang HY, Wang GQ, Xiong ZQ, Liao Z, Qian YY, Song X et al (2024) AR495 improves stress-induced irritable bowel syndrome in rats by targeting gut microbiota and mast cell-PAR2-TRPV1 signaling pathway. Food Sci Hum Well 13(2):698\u2013708 \/Fshw.2022.9250059. PubMed PMID: WOS:001097179300003","journal-title":"Food Sci Hum Well"},{"key":"3520_CR27","doi-asserted-by":"publisher","unstructured":"Konishi H, Fujiya M, Tanaka H, Ueno N, Moriichi K, Sasajima J et al (2016) Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis. Nat Commun. 7. doi: ARTN 12365 https:\/\/doi.org\/10.1038\/ncomms12365. PubMed PMID: WOS:000381525400001","DOI":"10.1038\/ncomms12365"},{"key":"3520_CR28","doi-asserted-by":"publisher","unstructured":"Johnson JS, Spakowicz DJ, Hong BY, Petersen LM, Demkowicz P, Chen L et al (2019) Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis. Nat Commun. 10. doi: ARTN 5029. https:\/\/doi.org\/10.1038\/s41467-019-13036-1. PubMed PMID: WOS:000494635700001","DOI":"10.1038\/s41467-019-13036-1"},{"issue":"5","key":"3520_CR29","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1093\/ibd\/izy318","volume":"25","author":"DAM Pedrogo","year":"2019","unstructured":"Pedrogo DAM, Chen J, Hillmann B, Jeraldo P, Al-Ghalith G, Taneja V et al (2019) An increased abundance of Clostridiaceae characterizes arthritis in inflammatory bowel disease and rheumatoid arthritis: a cross-sectional study. Inflamm Bowel Dis 25(5):902\u2013913. https:\/\/doi.org\/10.1093\/ibd\/izy318. PubMed PMID: WOS:000472798900020","journal-title":"Inflamm Bowel Dis"},{"key":"3520_CR30","doi-asserted-by":"publisher","unstructured":"Isokpehi RD, McInnis DS, Destefano AM, Johnson GS, Walker AD, Hall YA et al (2021) Bioinformatics Investigations of Universal Stress Proteins from Mercury-Methylating. Microorganisms. 9(8). doi: ARTN 1780 https:\/\/doi.org\/10.3390\/microorganisms9081780. PubMed PMID: WOS:000689535400001","DOI":"10.3390\/microorganisms9081780"},{"key":"3520_CR31","doi-asserted-by":"publisher","unstructured":"Lee KI, Jo Y, Yuk HJ, Kim SY, Kim H, Kim HJ et al (2024) Potential Phytotherapy of DSS-Induced Colitis: Ameliorating Reactive Oxygen Species-Mediated Necroptosis and Gut Dysbiosis with a New Bunge Variety-Daehong. Antioxidants-Basel. 13(3). doi: ARTN 340 https:\/\/doi.org\/10.3390\/antiox13030340. PubMed PMID: WOS:001191956200001","DOI":"10.3390\/antiox13030340"},{"issue":"7","key":"3520_CR32","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1039\/d3fo04419j","volume":"15","author":"CH Liu","year":"2024","unstructured":"Liu CH, Qi XF, Liu XL, Sun Y, Mao KD, Shen GQ et al (2024) Anti-inflammatory probiotics HF05 and HF06 synergistically alleviate ulcerative colitis and secondary liver injury. Food Funct 15(7):3765\u20133777. https:\/\/doi.org\/10.1039\/d3fo04419j. PubMed PMID: WOS:001195342500001","journal-title":"Food Funct"},{"key":"3520_CR33","doi-asserted-by":"publisher","unstructured":"Farhadipour M, Arnauts K, Clarysse M, Thijs T, Liszt K, van der Schueren B et al (2023) SCFAs switch stem cell fate through HDAC inhibition to improve barrier integrity in 3D intestinal organoids from patients with obesity. Iscience. 26(12). doi: ARTN 108517 https:\/\/doi.org\/10.1016\/j.isci.2023.108517. PubMed PMID: WOS:001134600000001","DOI":"10.1016\/j.isci.2023.108517"},{"issue":"12","key":"3520_CR34","doi-asserted-by":"publisher","first-page":"4801","DOI":"10.1016\/j.apsb.2023.09.010","volume":"13","author":"KK Zhang","year":"2023","unstructured":"Zhang KK, Chen LJ, Yang JZ, Liu JL, Li JH, Liu Y et al (2023) Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner. Acta Pharm Sin B 13(12):4801\u20134822. https:\/\/doi.org\/10.1016\/j.apsb.2023.09.010. PubMed PMID: WOS:001125953000001","journal-title":"Acta Pharm Sin B"},{"key":"3520_CR35","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02065-23","author":"JT Yang","year":"2023","unstructured":"Yang JT, Qin KL, Sun YP, Yang XJ (2023) Microbiota-accessible fiber activates short-chain fatty acid and bile acid metabolism to improve intestinal mucus barrier in broiler chickens. Microbiol Spectr. https:\/\/doi.org\/10.1128\/spectrum.02065-23. PubMed PMID: WOS:001127044100012","journal-title":"Microbiol Spectr"},{"key":"3520_CR36","doi-asserted-by":"publisher","unstructured":"Yan QZ, Jia SN, Li DF, Yang JL (2023) The role and mechanism of action of microbiota-derived short-chain fatty acids in neutrophils: From the activation to becoming potential biomarkers. Biomed Pharmacother. 169. doi: ARTN 115821 https:\/\/doi.org\/10.1016\/j.biopha.2023.115821. PubMed PMID: WOS:001112258700001","DOI":"10.1016\/j.biopha.2023.115821"},{"key":"3520_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105925","author":"F Yang","year":"2024","unstructured":"Yang F, Liu C, Lu XY, Liu SW, Zhang YX, Yu Y et al (2024) Improves postmenopausal osteoporosis through gut microbiota and short-chain fatty acids. J Funct Foods. 112. doi: ARTN 105925 https:\/\/doi.org\/10.1016\/j.jff.2023.105925","journal-title":"J Funct Foods"},{"key":"3520_CR38","doi-asserted-by":"publisher","unstructured":"Zhang MY, Pi YJ, Ma LT, Li FT, Luo J, Cai YY et al (2023) Effects of ginseng on short-chain fatty acids and intestinal microbiota in rats with spleen-qi deficiency based on gas chromatography-mass spectrometry and 16s rRNA technology. Rapid Commun Mass Sp. 37(23). doi: ARTN e9640 https:\/\/doi.org\/10.1002\/rcm.9640. PubMed PMID: WOS:001074749500001.","DOI":"10.1002\/rcm.9640"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-024-03520-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-024-03520-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-024-03520-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T09:26:16Z","timestamp":1739611576000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-024-03520-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["3520"],"URL":"https:\/\/doi.org\/10.1007\/s00394-024-03520-w","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,28]]},"assertion":[{"value":"11 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"32"}}