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We therefore aimed at investigating the association between Mg and vitamin D status in a large cohort of adult individuals with a high prevalence of deficient\/insufficient vitamin D and Mg status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We used data from the Ludwigshafen Risk and Cardiovascular Health Study (<jats:italic>n<\/jats:italic>\u2009=\u20092,286) to analyze differences according to serum Mg status in circulating 25-hydroxyvitamin D [25(OH)D] (primary endpoint), 24,25-dihydroxyvitamin D<jats:sub>3<\/jats:sub> [24,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>], vitamin D metabolite ratio and calcitriol, and odds ratios for deficient or insufficient 25(OH)D (secondary endpoints). We performed unadjusted and risk score (RS) adjusted and matched analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Of the study cohort (average age\u2009&gt;\u200960 years), one third was 25(OH)D deficient (&lt;\u200912 ng\/mL), one third 25(OH)D insufficient (12 to &lt;\u200920 ng\/mL), about 10% Mg deficient (&lt;\u20090.75 mmol\/L) and additional 40% potentially Mg deficient (0.75 to 0.85 mmol\/L). In adjusted\/matched analyses, 25(OH)D was only non-significantly lower in Mg deficient or insufficient groups versus their respective control group (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Only the RS-adjusted, but not the RS-matched odds ratio of 25(OH)D deficiency was significantly lower for the group with adequate versus deficient\/potentially deficient Mg status (0.83; 95%CI: 0.69\u20130.99), and only the RS-matched, but not the RS-adjusted odds ratio of 25(OH)D insufficiency was significantly lower for non-deficient versus deficient Mg status (0.69; 95%CI: 0.48\u20130.99). Other adjusted or matched secondary endpoints did not differ significantly between subgroups of Mg status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our data indicate only little effect between Mg and vitamin D status in adults with high prevalence of vitamin D deficiency and insufficiency.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00394-024-03559-9","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T14:16:31Z","timestamp":1734358591000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between magnesium and vitamin D status in adults with high prevalence of vitamin D deficiency and insufficiency"],"prefix":"10.1007","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-6554","authenticated-orcid":false,"given":"Armin","family":"Zittermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-0779","authenticated-orcid":false,"given":"Sieglinde","family":"Zelzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-7275","authenticated-orcid":false,"given":"Markus","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-8946","authenticated-orcid":false,"given":"Marcus","family":"Kleber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-1311","authenticated-orcid":false,"given":"Winfried","family":"Maerz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sefan","family":"Pilz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"issue":"3","key":"3559_CR1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","volume":"357","author":"MF Holick","year":"2007","unstructured":"Holick MF (2007) Vitamin D deficiency. 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