{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:38:20Z","timestamp":1790617100033,"version":"4.1.0"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Instituto de Investigaci\u00f3n Nutricional"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s00394-024-03564-y","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T09:16:25Z","timestamp":1734772585000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A comparative analysis of heme vs non-heme iron administration: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1007","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1484-4581","authenticated-orcid":false,"given":"Mariano","family":"Gallo Ruelas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7266-5808","authenticated-orcid":false,"given":"Giancarlo","family":"Alvarado-Gamarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-156X","authenticated-orcid":false,"given":"Adolfo","family":"Aramburu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7146-7885","authenticated-orcid":false,"given":"Gandy","family":"Dolores-Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2524-0465","authenticated-orcid":false,"given":"Karen","family":"Cueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8890-8811","authenticated-orcid":false,"given":"Gabriela","family":"Rojas-Limache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1037-2417","authenticated-orcid":false,"given":"Carmen del Pilar","family":"Diaz-Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-7425","authenticated-orcid":false,"given":"Claudio F.","family":"Lanata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,21]]},"reference":[{"key":"3564_CR1","volume-title":"Iron deficiency anemia","author":"MJ Warner","year":"2024","unstructured":"Warner MJ, Kamran MT (2024) Iron deficiency anemia. StatPearls Publishing, Treasure Island"},{"key":"3564_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s13045-021-01202-2","volume":"14","author":"S Safiri","year":"2021","unstructured":"Safiri S, Kolahi A-A, Noori M et al (2021) Burden of anemia and its underlying causes in 204 countries and territories, 1990\u20132019: results from the Global Burden of Disease Study 2019. J Hematol OncolJ Hematol Oncol 14:185. https:\/\/doi.org\/10.1186\/s13045-021-01202-2","journal-title":"J Hematol OncolJ Hematol Oncol"},{"key":"3564_CR3","doi-asserted-by":"publisher","first-page":"777","DOI":"10.3390\/brainsci11060777","volume":"11","author":"W-M Kung","year":"2021","unstructured":"Kung W-M, Yuan S-P, Lin M-S et al (2021) Anemia and the risk of cognitive impairment: an updated systematic review and meta-analysis. Brain Sci 11:777. https:\/\/doi.org\/10.3390\/brainsci11060777","journal-title":"Brain Sci"},{"key":"3564_CR4","doi-asserted-by":"publisher","first-page":"e713","DOI":"10.1016\/S2352-3026(23)00160-6","volume":"10","author":"WM Gardner","year":"2023","unstructured":"Gardner WM, Razo C, McHugh TA et al (2023) Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990\u20132021: findings from the Global Burden of Disease Study 2021. Lancet Haematol 10:e713\u2013e734. https:\/\/doi.org\/10.1016\/S2352-3026(23)00160-6","journal-title":"Lancet Haematol"},{"key":"3564_CR5","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.2899","volume":"1","author":"F Yang","year":"2018","unstructured":"Yang F, Liu X, Zha P (2018) Trends in socioeconomic inequalities and prevalence of anemia among children and nonpregnant women in low- and middle-income countries. JAMA Netw Open 1:e182899. https:\/\/doi.org\/10.1001\/jamanetworkopen.2018.2899","journal-title":"JAMA Netw Open"},{"key":"3564_CR6","doi-asserted-by":"publisher","first-page":"20335","DOI":"10.1038\/s41598-023-46739-z","volume":"13","author":"AZ Alem","year":"2023","unstructured":"Alem AZ, Efendi F, McKenna L et al (2023) Prevalence and factors associated with anemia in women of reproductive age across low- and middle-income countries based on national data. Sci Rep 13:20335. https:\/\/doi.org\/10.1038\/s41598-023-46739-z","journal-title":"Sci Rep"},{"key":"3564_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101136","author":"J Sun","year":"2021","unstructured":"Sun J, Wu H, Zhao M et al (2021) Prevalence and changes of anemia among young children and women in 47 low- and middle-income countries, 2000\u20132018. ClinicalMedicine. https:\/\/doi.org\/10.1016\/j.eclinm.2021.101136","journal-title":"ClinicalMedicine"},{"key":"3564_CR8","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1017\/S1368980018001775","volume":"21","author":"S Moradi","year":"2018","unstructured":"Moradi S, Arghavani H, Issah A et al (2018) Food insecurity and anaemia risk: a systematic review and meta-analysis. Public Health Nutr 21:3067\u20133079. https:\/\/doi.org\/10.1017\/S1368980018001775","journal-title":"Public Health Nutr"},{"key":"3564_CR9","unstructured":"Accelerating anaemia reduction: a comprehensive framework for action. https:\/\/www.who.int\/publications-detail-redirect\/9789240074033. Accessed 1 Mar 2024"},{"key":"3564_CR10","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1016\/S0140-6736(10)62304-5","volume":"378","author":"Y Balarajan","year":"2011","unstructured":"Balarajan Y, Ramakrishnan U, \u00d6zaltin E et al (2011) Anaemia in low-income and middle-income countries. The Lancet 378:2123\u20132135. https:\/\/doi.org\/10.1016\/S0140-6736(10)62304-5","journal-title":"The Lancet"},{"key":"3564_CR11","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2022-010745","volume":"8","author":"CT Andersen","year":"2023","unstructured":"Andersen CT, Marsden DM, Duggan CP et al (2023) Oral iron supplementation and anaemia in children according to schedule, duration, dose and cosupplementation: a systematic review and meta-analysis of 129 randomised trials. BMJ Glob Health 8:e010745. https:\/\/doi.org\/10.1136\/bmjgh-2022-010745","journal-title":"BMJ Glob Health"},{"key":"3564_CR12","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jpeds.2019.12.040","volume":"219","author":"JM Powers","year":"2020","unstructured":"Powers JM, Nagel M, Raphael JL et al (2020) Barriers to and facilitators of iron therapy in children with iron deficiency anemia. J Pediatr 219:202\u2013208. https:\/\/doi.org\/10.1016\/j.jpeds.2019.12.040","journal-title":"J Pediatr"},{"key":"3564_CR13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.11604\/pamj.2019.34.211.16446","volume":"34","author":"FY Fouelifack","year":"2019","unstructured":"Fouelifack FY, Sama JD, Sone CE (2019) Assessment of adherence to iron supplementation among pregnant women in the Yaounde gynaeco-obstetric and paediatric hospital. Pan Afr Med J. 34:211. https:\/\/doi.org\/10.11604\/pamj.2019.34.211.16446","journal-title":"Pan Afr Med J."},{"key":"3564_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117383","volume":"10","author":"Z Tolkien","year":"2015","unstructured":"Tolkien Z, Stecher L, Mander AP et al (2015) Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS ONE 10:e0117383. https:\/\/doi.org\/10.1371\/journal.pone.0117383","journal-title":"PLoS ONE"},{"key":"3564_CR15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3390\/nu8020088","volume":"8","author":"S Hess","year":"2016","unstructured":"Hess S, Tecklenburg L, Eichler K (2016) Micronutrient fortified condiments and noodles to reduce anemia in children and adults\u2014a literature review and meta-analysis. Nutrients 8:88. https:\/\/doi.org\/10.3390\/nu8020088","journal-title":"Nutrients"},{"key":"3564_CR16","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1080\/14767058.2017.1406915","volume":"32","author":"S Iqbal","year":"2019","unstructured":"Iqbal S, Ekmekcioglu C (2019) Maternal and neonatal outcomes related to iron supplementation or iron status: a summary of meta-analyses. J Matern-Fetal Neonatal Med 32:1528\u20131540. https:\/\/doi.org\/10.1080\/14767058.2017.1406915","journal-title":"J Matern-Fetal Neonatal Med"},{"key":"3564_CR17","doi-asserted-by":"publisher","first-page":"3465","DOI":"10.1017\/S1368980019002179","volume":"22","author":"J Sadighi","year":"2019","unstructured":"Sadighi J, Nedjat S, Rostami R (2019) Systematic review and meta-analysis of the effect of iron-fortified flour on iron status of populations worldwide. Public Health Nutr 22:3465\u20133484. https:\/\/doi.org\/10.1017\/S1368980019002179","journal-title":"Public Health Nutr"},{"key":"3564_CR18","doi-asserted-by":"publisher","first-page":"513","DOI":"10.4103\/jfmpc.jfmpc_817_19","volume":"9","author":"R Athe","year":"2020","unstructured":"Athe R, Dwivedi R, Pati S et al (2020) Meta-analysis approach on iron fortification and its effect on pregnancy and its outcome through randomized, controlled trials. J Fam Med Prim Care 9:513. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_817_19","journal-title":"J Fam Med Prim Care"},{"key":"3564_CR19","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1017\/S1368980013000062","volume":"17","author":"R Athe","year":"2014","unstructured":"Athe R, Rao MVV, Nair KM (2014) Impact of iron-fortified foods on Hb concentration in children (<10 years): a systematic review and meta-analysis of randomized controlled trials. Public Health Nutr 17:579\u2013586. https:\/\/doi.org\/10.1017\/S1368980013000062","journal-title":"Public Health Nutr"},{"key":"3564_CR20","doi-asserted-by":"publisher","first-page":"5073","DOI":"10.3390\/nu15245073","volume":"15","author":"Y Sun","year":"2023","unstructured":"Sun Y, Ma J, Wei X et al (2023) Barriers to and facilitators of the implementation of a micronutrient powder program for children: a systematic review based on the consolidated framework for implementation research. Nutrients 15:5073. https:\/\/doi.org\/10.3390\/nu15245073","journal-title":"Nutrients"},{"key":"3564_CR21","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.3390\/antiox12051074","volume":"12","author":"VA Voltarelli","year":"2023","unstructured":"Voltarelli VA, Alves de Souza RW, Miyauchi K et al (2023) Heme: the lord of the iron ring. Antioxidants 12:1074. https:\/\/doi.org\/10.3390\/antiox12051074","journal-title":"Antioxidants"},{"key":"3564_CR22","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/S0271-5317(00)00215-3","volume":"20","author":"PA Seligman","year":"2000","unstructured":"Seligman PA, Moore GM, Schleicher RB (2000) Clinical studies of hip: an oral heme-iron product. Nutr Res 20:1279\u20131286. https:\/\/doi.org\/10.1016\/S0271-5317(00)00215-3","journal-title":"Nutr Res"},{"key":"3564_CR23","doi-asserted-by":"publisher","first-page":"4101","DOI":"10.3748\/wjg.14.4101","volume":"14","author":"AR West","year":"2008","unstructured":"West AR, Oates PS (2008) Mechanisms of heme iron absorption: current questions and controversies. World J Gastroenterol WJG 14:4101\u20134110. https:\/\/doi.org\/10.3748\/wjg.14.4101","journal-title":"World J Gastroenterol WJG"},{"key":"3564_CR24","doi-asserted-by":"publisher","first-page":"1461S","DOI":"10.3945\/ajcn.2010.28674F","volume":"91","author":"R Hurrell","year":"2010","unstructured":"Hurrell R, Egli I (2010) Iron bioavailability and dietary reference values. Am J Clin Nutr 91:1461S-1467S. https:\/\/doi.org\/10.3945\/ajcn.2010.28674F","journal-title":"Am J Clin Nutr"},{"key":"3564_CR25","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.3945\/jn.110.127209","volume":"140","author":"MF Young","year":"2010","unstructured":"Young MF, Griffin I, Pressman E et al (2010) Utilization of iron from an animal-based iron source is greater than that of ferrous sulfate in pregnant and nonpregnant women. J Nutr 140:2162\u20132166. https:\/\/doi.org\/10.3945\/jn.110.127209","journal-title":"J Nutr"},{"key":"3564_CR26","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/S0002-8223(21)07902-5","volume":"88","author":"ER Monsen","year":"1988","unstructured":"Monsen ER (1988) Iron nutrition and absorption: dietary factors which impact iron bioavailability. J Am Diet Assoc 88:786\u2013790","journal-title":"J Am Diet Assoc"},{"key":"3564_CR27","unstructured":"Chen Weilin, Wu Yuming, Li Zimin (2012) Effect of the heme iron supplement on improving nutritional anemia in women. Chin J Food Hygiene. pp 309\u2013311"},{"key":"3564_CR28","first-page":"167","volume":"2","author":"ZK Gaofeng","year":"2010","unstructured":"Gaofeng ZK, Lan S, Song Xintian Wu, Xiaogang ZJ (2010) A human trial study on the effect of heme iron capsule on improving iron deficiency anemia. Occupation Health Issue 2:167\u2013168","journal-title":"Occupation Health Issue"},{"key":"3564_CR29","first-page":"753","volume":"48","author":"M Fogelholm","year":"1994","unstructured":"Fogelholm M, Suominen M, Rita H (1994) Effects of low-dose iron supplementation in women with low serum ferritin concentration. Eur J Clin Nutr 48:753\u2013756","journal-title":"Eur J Clin Nutr"},{"key":"3564_CR30","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1093\/ajcn\/57.2.190","volume":"57","author":"T Walter","year":"1993","unstructured":"Walter T, Hertrampf E, Pizarro F et al (1993) Effect of bovine-hemoglobin-fortified cookies on iron status of schoolchildren: a nationwide program in Chile. Am J Clin Nutr 57:190\u2013194. https:\/\/doi.org\/10.1093\/ajcn\/57.2.190","journal-title":"Am J Clin Nutr"},{"key":"3564_CR31","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/s0272-6386(03)00658-9","volume":"42","author":"AR Nissenson","year":"2003","unstructured":"Nissenson AR, Berns JS, Sakiewicz P et al (2003) Clinical evaluation of heme iron polypeptide: sustaining a response to rHuEPO in hemodialysis patients. Am J Kidney Dis 42:325\u2013330. https:\/\/doi.org\/10.1016\/s0272-6386(03)00658-9","journal-title":"Am J Kidney Dis"},{"key":"3564_CR32","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.1093\/ndt\/gfs372","volume":"27","author":"KA Barraclough","year":"2012","unstructured":"Barraclough KA, Brown F, Hawley CM et al (2012) A randomized controlled trial of oral heme iron polypeptide versus oral iron supplementation for the treatment of anaemia in peritoneal dialysis patients: HEMATOCRIT trial. Nephrol Dial Transplant 27:4146\u20134153. https:\/\/doi.org\/10.1093\/ndt\/gfs372","journal-title":"Nephrol Dial Transplant"},{"key":"3564_CR33","doi-asserted-by":"publisher","first-page":"56","DOI":"10.5530\/ami.2017.4.11","volume":"4","author":"IA Abdelazim","year":"2017","unstructured":"Abdelazim IA, Abu-Faza M, Elbiaa AAM et al (2017) Heme iron polypeptide (Proferrin\u00ae-ES) versus iron saccharate complex (ferrosac) for treatment of iron deficiency anemia during pregnancy. Acta Medica Int 4:56. https:\/\/doi.org\/10.5530\/ami.2017.4.11","journal-title":"Acta Medica Int"},{"key":"3564_CR34","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s11695-017-2858-4","volume":"28","author":"RA Mischler","year":"2018","unstructured":"Mischler RA, Armah SM, Craig BA et al (2018) Comparison of oral iron supplement formulations for normalization of iron status following Roux-EN-y gastric bypass surgery: a randomized trial. Obes Surg 28:369\u2013377. https:\/\/doi.org\/10.1007\/s11695-017-2858-4","journal-title":"Obes Surg"},{"key":"3564_CR35","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1471-2369-14-64","volume":"14","author":"SP Nagaraju","year":"2013","unstructured":"Nagaraju SP, Cohn A, Akbari A et al (2013) Heme iron polypeptide for the treatment of iron deficiency anemia in non-dialysis chronic kidney disease patients: a randomized controlled trial. BMC Nephrol 14:64. https:\/\/doi.org\/10.1186\/1471-2369-14-64","journal-title":"BMC Nephrol"},{"key":"3564_CR36","doi-asserted-by":"publisher","first-page":"1606S","DOI":"10.3945\/ajcn.117.155887","volume":"106","author":"CM Pfeiffer","year":"2017","unstructured":"Pfeiffer CM, Looker AC (2017) Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges. Am J Clin Nutr 106:1606S-1614S. https:\/\/doi.org\/10.3945\/ajcn.117.155887","journal-title":"Am J Clin Nutr"},{"key":"3564_CR37","unstructured":"Assessing the iron status of populations: including literature reviews. https:\/\/www.who.int\/publications-detail-redirect\/9789241596107. Accessed 17 Feb 2024"},{"key":"3564_CR38","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"3564_CR39","unstructured":"Cochrane Handbook for Systematic Reviews of Interventions. https:\/\/training.cochrane.org\/handbook. Accessed 2 Mar 2024"},{"key":"3564_CR40","unstructured":"(2011) Definition of side effect - NCI Dictionary of Cancer Terms - NCI. https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/side-effect. Accessed 2 Jul 2024"},{"key":"3564_CR41","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1177\/0145445516673998","volume":"41","author":"D Drevon","year":"2017","unstructured":"Drevon D, Fursa SR, Malcolm AL (2017) Intercoder reliability and validity of WebPlotDigitizer in extracting graphed data. Behav Modif 41:323\u2013339. https:\/\/doi.org\/10.1177\/0145445516673998","journal-title":"Behav Modif"},{"key":"3564_CR42","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1093\/jn\/137.3.620","volume":"137","author":"JH Swain","year":"2007","unstructured":"Swain JH, Johnson LK, Hunt JR (2007) Electrolytic iron or ferrous sulfate increase body iron in women with moderate to low iron stores. J Nutr 137:620\u2013627. https:\/\/doi.org\/10.1093\/jn\/137.3.620","journal-title":"J Nutr"},{"key":"3564_CR43","doi-asserted-by":"publisher","first-page":"55","DOI":"10.12873\/441palomino","volume":"44","author":"LP Palomino Quispe","year":"2024","unstructured":"Palomino Quispe LP, Rom\u00e1n FP (2024) Comparative efficacy of supplement and dietary supplement in the treatment of iron deficiency anemia in Peruvian children. Nutr Clin Diet Hosp. 44:55\u201365. https:\/\/doi.org\/10.12873\/441palomino","journal-title":"Nutr Clin Diet Hosp."},{"key":"3564_CR44","unstructured":"RoB 2: A revised Cochrane risk-of-bias tool for randomized trials | Cochrane Bias. https:\/\/methods.cochrane.org\/bias\/resources\/rob-2-revised-cochrane-risk-bias-tool-randomized-trials. Accessed 2 Mar 2024"},{"key":"3564_CR45","unstructured":"Risk of bias tools\u2014Current version of RoB 2. https:\/\/www.riskofbias.info\/welcome\/rob-2-0-tool\/current-version-of-rob-2. Accessed 2 Mar 2024"},{"key":"3564_CR46","unstructured":"Effect of low-dose ferrous sulfate vs iron polysaccharide complex on hemoglobin concentration in young children with nutritional iron-deficiency anemia: a randomized clinical trial | Hematology | JAMA | JAMA Network. https:\/\/jamanetwork.com\/journals\/jama\/article-abstract\/2631530. Accessed 1 Jul 2024"},{"key":"3564_CR47","volume-title":"Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors","author":"M Ezzati","year":"2004","unstructured":"Ezzati M, Lopez AD, Rodgers AA, Murray CJL (2004) Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors. World Health Organization"},{"key":"3564_CR48","unstructured":"GRADE handbook. https:\/\/gdt.gradepro.org\/app\/handbook\/handbook.html. Accessed 9 Feb 2024"},{"key":"3564_CR49","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-024-01992-8","author":"AN \u0160mid","year":"2024","unstructured":"\u0160mid AN, Golja P, Had\u017ei\u0107 V et al (2024) Effects of oral iron supplementation on blood iron status in athletes: a systematic review, meta-analysis and meta-regression of randomized controlled trials. Sports Med. https:\/\/doi.org\/10.1007\/s40279-024-01992-8","journal-title":"Sports Med"},{"key":"3564_CR50","unstructured":"Chapter 10: Analysing data and undertaking meta-analyses. https:\/\/training.cochrane.org\/handbook\/current\/chapter-10. Accessed 1 Feb 2024"},{"key":"3564_CR51","unstructured":"The Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital\u2014Rigshospitalet (2021) Trial Sequential Analysis (TSA) [Computer program]"},{"key":"3564_CR52","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13643-018-0770-1","volume":"7","author":"G Castellini","year":"2018","unstructured":"Castellini G, Bruschettini M, Gianola S et al (2018) Assessing imprecision in Cochrane systematic reviews: a comparison of GRADE and Trial Sequential Analysis. Syst Rev 7:110. https:\/\/doi.org\/10.1186\/s13643-018-0770-1","journal-title":"Syst Rev"},{"key":"3564_CR53","unstructured":"RevMan Calculator. https:\/\/training.cochrane.org\/resource\/revman-calculator. Accessed 31 Jan 2024"},{"key":"3564_CR54","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/jrsm.1686","volume":"15","author":"S McGrath","year":"2024","unstructured":"McGrath S, Zhao X, Ozturk O et al (2024) Metamedian: an R package for meta-analyzing studies reporting medians. Res Synth Methods 15:332\u2013346. https:\/\/doi.org\/10.1002\/jrsm.1686","journal-title":"Res Synth Methods"},{"key":"3564_CR55","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1080\/07315724.2015.1060875","volume":"35","author":"AG Quintero-Guti\u00e9rrez","year":"2016","unstructured":"Quintero-Guti\u00e9rrez AG, Gonz\u00e1lez-Rosendo G, Pozo JP, Villanueva-S\u00e1nchez J (2016) Heme iron concentrate and iron sulfate added to chocolate biscuits: effects on hematological indices of mexican schoolchildren. J Am Coll Nutr 35:544\u2013551. https:\/\/doi.org\/10.1080\/07315724.2015.1060875","journal-title":"J Am Coll Nutr"},{"key":"3564_CR56","doi-asserted-by":"publisher","first-page":"845","DOI":"10.4045\/tidsskr.11.0164","volume":"133","author":"RJ Ulvik","year":"2013","unstructured":"Ulvik RJ, M\u00f8ller R, Hervig T (2013) Dietary supplement of iron for iron deficiency. Tidsskr Den Nor Laegeforening Tidsskr Prakt Med Ny Raekke 133:845\u2013849. https:\/\/doi.org\/10.4045\/tidsskr.11.0164","journal-title":"Tidsskr Den Nor Laegeforening Tidsskr Prakt Med Ny Raekke"},{"key":"3564_CR57","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.nut.2012.04.013","volume":"29","author":"M Hoppe","year":"2013","unstructured":"Hoppe M, Br\u00fcn B, Larsson MP et al (2013) Heme iron-based dietary intervention for improvement of iron status in young women. Nutr Burbank Los Angel Cty Calif 29:89\u201395. https:\/\/doi.org\/10.1016\/j.nut.2012.04.013","journal-title":"Nutr Burbank Los Angel Cty Calif"},{"key":"3564_CR58","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/19476337.2011.596284","volume":"10","author":"AG Quintero Guti\u00e9rrez","year":"2012","unstructured":"Quintero Guti\u00e9rrez AG, Mariaca Gaspar GI, Villanueva S\u00e1nchez J et al (2012) Acceptability and use of heme-iron concentrate product added to chocolate biscuit filling as an alternative source of a highly available form of iron. CyTA J Food 10:112\u2013118","journal-title":"CyTA J Food"},{"key":"3564_CR59","doi-asserted-by":"publisher","first-page":"H73","DOI":"10.1111\/j.1750-3841.2010.01523.x","volume":"75","author":"G Gonz\u00e1lez-Rosendo","year":"2010","unstructured":"Gonz\u00e1lez-Rosendo G, Polo J, Rodr\u00edguez-Jerez JJ et al (2010) Bioavailability of a heme-iron concentrate product added to chocolate biscuit filling in adolescent girls living in a rural area of Mexico. J Food Sci 75:H73-78. https:\/\/doi.org\/10.1111\/j.1750-3841.2010.01523.x","journal-title":"J Food Sci"},{"key":"3564_CR60","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1079\/phn2004708","volume":"8","author":"K Sch\u00fcmann","year":"2005","unstructured":"Sch\u00fcmann K, Romero-Abal ME, M\u00e4urer A et al (2005) Haematological response to haem iron or ferrous sulphate mixed with refried black beans in moderately anaemic Guatemalan pre-school children. Public Health Nutr 8:572\u2013581. https:\/\/doi.org\/10.1079\/phn2004708","journal-title":"Public Health Nutr"},{"key":"3564_CR61","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1034\/j.1600-0412.2003.00139.x","volume":"82","author":"B Sandstad","year":"2003","unstructured":"Sandstad B, Borch-Iohnsen B, Andersen GM et al (2003) Selective iron supplementation based on serum ferritin values early in pregnancy: are the Norwegian recommendations satisfactory? Acta Obstet Gynecol Scand 82:537\u2013542. https:\/\/doi.org\/10.1034\/j.1600-0412.2003.00139.x","journal-title":"Acta Obstet Gynecol Scand"},{"key":"3564_CR62","doi-asserted-by":"publisher","first-page":"822","DOI":"10.3109\/00016349709024359","volume":"76","author":"B Eskeland","year":"1997","unstructured":"Eskeland B, Malterud K, Ulvik RJ, Hunskaar S (1997) Iron supplementation in pregnancy: is less enough? A randomized, placebo controlled trial of low dose iron supplementation with and without heme iron. Acta Obstet Gynecol Scand 76:822\u2013828. https:\/\/doi.org\/10.3109\/00016349709024359","journal-title":"Acta Obstet Gynecol Scand"},{"key":"3564_CR63","first-page":"561","volume":"123","author":"E Frykman","year":"1994","unstructured":"Frykman E, Bystrom M, Jansson U et al (1994) Side effects of iron supplements in blood donors: superior tolerance of heme iron. J Lab Clin Med 123:561\u2013564","journal-title":"J Lab Clin Med"},{"key":"3564_CR64","doi-asserted-by":"publisher","first-page":"789","DOI":"10.3109\/00365519309086490","volume":"53","author":"B Borch-Iohnsen","year":"1993","unstructured":"Borch-Iohnsen B, Halvorsen R, Stenberg V et al (1993) The effect of daily low-dose iron supplements in female blood donors with depleted iron stores: comparison with female non-donors. Scand J Clin Lab Invest 53:789\u2013791. https:\/\/doi.org\/10.3109\/00365519309086490","journal-title":"Scand J Clin Lab Invest"},{"key":"3564_CR65","first-page":"1990","volume":"109","author":"B Borch-Iohnsen","year":"1989","unstructured":"Borch-Iohnsen B, Meltzer HM, Trygg K et al (1989) Women and iron deficiency\u2013a problem? Iron levels in a group of fertile Norwegian women and the bioavailability of 3 low-dose iron supplements in women with low iron stores. Tidsskr Den Nor Laegeforening Tidsskr Prakt Med Ny Raekke 109:1990\u20131995","journal-title":"Tidsskr Den Nor Laegeforening Tidsskr Prakt Med Ny Raekke"},{"key":"3564_CR66","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/s13063-024-08101-0","volume":"25","author":"M Bah","year":"2024","unstructured":"Bah M, Verhoef H, Okoh E et al (2024) Haem iron versus ferrous iron salts to treat iron deficiency anaemia in Gambian children: protocol for randomised controlled trial {1}. Trials 25:270. https:\/\/doi.org\/10.1186\/s13063-024-08101-0","journal-title":"Trials"},{"key":"3564_CR67","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/jcpt.12281","volume":"40","author":"RB Dull","year":"2015","unstructured":"Dull RB, Davis E (2015) Heme iron polypeptide for the management of anaemia of chronic kidney disease. J Clin Pharm Ther 40:386\u2013390. https:\/\/doi.org\/10.1111\/jcpt.12281","journal-title":"J Clin Pharm Ther"},{"key":"3564_CR68","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3390\/metabo14040228","volume":"14","author":"M Correnti","year":"2024","unstructured":"Correnti M, Gammella E, Cairo G, Recalcati S (2024) Iron absorption: molecular and pathophysiological aspects. Metabolites 14:228. https:\/\/doi.org\/10.3390\/metabo14040228","journal-title":"Metabolites"},{"key":"3564_CR69","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1093\/ajcn\/31.1.134","volume":"31","author":"ER Monsen","year":"1978","unstructured":"Monsen ER, Hallberg L, Layrisse M et al (1978) Estimation of available dietary iron. Am J Clin Nutr 31:134\u2013141. https:\/\/doi.org\/10.1093\/ajcn\/31.1.134","journal-title":"Am J Clin Nutr"},{"key":"3564_CR70","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1093\/ajcn\/71.5.1147","volume":"71","author":"L Hallberg","year":"2000","unstructured":"Hallberg L, Hulth\u00e9n L (2000) Prediction of dietary iron absorption: an algorithm for calculating absorption and bioavailability of dietary iron. Am J Clin Nutr 71:1147\u20131160. https:\/\/doi.org\/10.1093\/ajcn\/71.5.1147","journal-title":"Am J Clin Nutr"},{"key":"3564_CR71","unstructured":"Recent advances in the formulation strategy to improve iron bioavailability: A review. ScienceDirect. https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1773224724003022. Accessed 10 Jul 2024"},{"key":"3564_CR72","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.ajcnut.2022.10.003","volume":"117","author":"HK von Siebenthal","year":"2023","unstructured":"von Siebenthal HK, Galetti V, Zimmermann MB, Stoffel NU (2023) Regulation of iron absorption in infants. Am J Clin Nutr 117:607\u2013615. https:\/\/doi.org\/10.1016\/j.ajcnut.2022.10.003","journal-title":"Am J Clin Nutr"},{"key":"3564_CR73","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev.nu.01.070181.001011","volume":"1","author":"L Hallberg","year":"1981","unstructured":"Hallberg L (1981) Bioavailability of dietary iron in man. Annu Rev Nutr 1:123\u2013147. https:\/\/doi.org\/10.1146\/annurev.nu.01.070181.001011","journal-title":"Annu Rev Nutr"},{"key":"3564_CR74","doi-asserted-by":"publisher","first-page":"4425","DOI":"10.1182\/blood-2011-01-258467","volume":"117","author":"T Ganz","year":"2011","unstructured":"Ganz T (2011) Hepcidin and iron regulation, 10 years later. Blood 117:4425\u20134433. https:\/\/doi.org\/10.1182\/blood-2011-01-258467","journal-title":"Blood"},{"key":"3564_CR75","first-page":"91","volume":"44","author":"S Hirve","year":"2007","unstructured":"Hirve S, Bhave S, Bavdekar A et al (2007) Low dose \u2019Sprinkles\u2019\u2014an innovative approach to treat iron deficiency anemia in infants and young children. Indian Pediatr 44:91\u2013100","journal-title":"Indian Pediatr"},{"key":"3564_CR76","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1093\/jn\/137.4.1023","volume":"137","author":"P Menon","year":"2007","unstructured":"Menon P, Ruel MT, Loechl CU et al (2007) Micronutrient sprinkles reduce anemia among 9- to 24-mo-old children when delivered through an integrated health and nutrition program in rural Haiti1. J Nutr 137:1023\u20131030. https:\/\/doi.org\/10.1093\/jn\/137.4.1023","journal-title":"J Nutr"},{"key":"3564_CR77","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3945\/ajcn.111.030072","volume":"95","author":"PS Suchdev","year":"2012","unstructured":"Suchdev PS, Ruth LJ, Woodruff BA et al (2012) Selling Sprinkles micronutrient powder reduces anemia, iron deficiency, and vitamin A deficiency in young children in Western Kenya: a cluster-randomized controlled trial1234. Am J Clin Nutr 95:1223\u20131230. https:\/\/doi.org\/10.3945\/ajcn.111.030072","journal-title":"Am J Clin Nutr"},{"key":"3564_CR78","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.18203\/2394-6040.ijcmph20231693","volume":"10","author":"JP Mishra","year":"2023","unstructured":"Mishra JP, Ramakrishnan J, Ramasubramani P et al (2023) Adherence and barriers of prophylactic iron and folic acid supplementation in children: a community-based mixed method study. Int J Commun Med Public Health. 10:2138\u20132143. https:\/\/doi.org\/10.18203\/2394-6040.ijcmph20231693","journal-title":"Int J Commun Med Public Health."},{"key":"3564_CR79","doi-asserted-by":"publisher","first-page":"288","DOI":"10.5546\/aap.2013.xx","volume":"111","author":"L Christensen","year":"2013","unstructured":"Christensen L, Sguassero Y, Cuesta CB (2013) Anemia y adherencia a la suplementaci\u00f3n oral con hierro en una muestra de ni\u00f1os usuarios de la red de salud p\u00fablica de Rosario, Santa Fe. Arch Argent Pediatr\u00eda 111:288\u2013294. https:\/\/doi.org\/10.5546\/aap.2013.xx","journal-title":"Arch Argent Pediatr\u00eda"},{"key":"3564_CR80","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1590\/1980-5497201600030006","volume":"19","author":"O Munares-Garc\u00eda","year":"2016","unstructured":"Munares-Garc\u00eda O, G\u00f3mez-Guizado G (2016) Adherence to multiple micronutrient powders and associated factors in children aged 6 to 35 months treated in sentinel health facilities, Ministry of Health of Peru. Rev Bras Epidemiol 19:539\u2013553. https:\/\/doi.org\/10.1590\/1980-5497201600030006","journal-title":"Rev Bras Epidemiol"},{"key":"3564_CR81","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5785","volume":"349","author":"OP Attanasio","year":"2014","unstructured":"Attanasio OP, Fern\u00e1ndez C, Fitzsimons EOA et al (2014) Using the infrastructure of a conditional cash transfer program to deliver a scalable integrated early child development program in Colombia: cluster randomized controlled trial. BMJ 349:g5785. https:\/\/doi.org\/10.1136\/bmj.g5785","journal-title":"BMJ"},{"key":"3564_CR82","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1182\/blood-2015-09-666511","volume":"126","author":"SL Schrier","year":"2015","unstructured":"Schrier SL (2015) So you know how to treat iron deficiency anemia. Blood 126:1971. https:\/\/doi.org\/10.1182\/blood-2015-09-666511","journal-title":"Blood"},{"key":"3564_CR83","doi-asserted-by":"publisher","first-page":"918","DOI":"10.3390\/nu11040918","volume":"11","author":"M Kyaw Htet","year":"2019","unstructured":"Kyaw Htet M, Fahmida U, Dillon D et al (2019) Is iron supplementation influenced by sub-clinical inflammation?: A randomized controlled trial among adolescent schoolgirls in Myanmar. Nutrients 11:918. https:\/\/doi.org\/10.3390\/nu11040918","journal-title":"Nutrients"},{"key":"3564_CR84","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1182\/blood.V56.1.138.138","volume":"56","author":"MS Wheby","year":"1980","unstructured":"Wheby MS (1980) Effect of iron therapy on serum ferritin levels in iron-deficiency anemia. Blood 56:138\u2013140. https:\/\/doi.org\/10.1182\/blood.V56.1.138.138","journal-title":"Blood"},{"key":"3564_CR85","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1093\/ajcn\/35.1.95","volume":"35","author":"T-T Thane-Toe","year":"1982","unstructured":"Thane-Toe T-T (1982) The effects of oral iron supplementation on ferritin levels in pregnant Burmese women. Am J Clin Nutr 35:95\u201399. https:\/\/doi.org\/10.1093\/ajcn\/35.1.95","journal-title":"Am J Clin Nutr"},{"key":"3564_CR86","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1182\/blood-2015-05-642223","volume":"126","author":"D Moretti","year":"2015","unstructured":"Moretti D, Goede JS, Zeder C et al (2015) Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women. Blood 126:1981\u20131989. https:\/\/doi.org\/10.1182\/blood-2015-05-642223","journal-title":"Blood"},{"key":"3564_CR87","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1093\/ajcn\/69.2.250","volume":"69","author":"EK Lund","year":"1999","unstructured":"Lund EK, Wharf SG, Fairweather-Tait SJ, Johnson IT (1999) Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteers. Am J Clin Nutr 69:250\u2013255. https:\/\/doi.org\/10.1093\/ajcn\/69.2.250","journal-title":"Am J Clin Nutr"},{"key":"3564_CR88","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1475-2891-3-2","volume":"3","author":"AE Fisher","year":"2004","unstructured":"Fisher AE, Naughton DP (2004) Iron supplements: the quick fix with long-term consequences. Nutr J 3:2. https:\/\/doi.org\/10.1186\/1475-2891-3-2","journal-title":"Nutr J"},{"key":"3564_CR89","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1136\/gutjnl-2014-307720","volume":"64","author":"T Jaeggi","year":"2015","unstructured":"Jaeggi T, Kortman GAM, Moretti D et al (2015) Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut 64:731\u2013742. https:\/\/doi.org\/10.1136\/gutjnl-2014-307720","journal-title":"Gut"},{"key":"3564_CR90","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1136\/gutjnl-2017-314418","volume":"66","author":"D Paganini","year":"2017","unstructured":"Paganini D, Uyoga MA, Kortman GAM et al (2017) Prebiotic galacto-oligosaccharides mitigate the adverse effects of iron fortification on the gut microbiome: a randomised controlled study in Kenyan infants. Gut 66:1956\u20131967. https:\/\/doi.org\/10.1136\/gutjnl-2017-314418","journal-title":"Gut"},{"key":"3564_CR91","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1136\/gutjnl-2018-316988","volume":"68","author":"K Simonyt\u00e9 Sj\u00f6din","year":"2019","unstructured":"Simonyt\u00e9 Sj\u00f6din K, Domell\u00f6f M, Lagerqvist C et al (2019) Administration of ferrous sulfate drops has significant effects on the gut microbiota of iron-sufficient infants: a randomised controlled study. Gut 68:2095\u20132097. https:\/\/doi.org\/10.1136\/gutjnl-2018-316988","journal-title":"Gut"},{"key":"3564_CR92","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.freeradbiomed.2007.03.011","volume":"43","author":"GGC Kuhnle","year":"2007","unstructured":"Kuhnle GGC, Story GW, Reda T et al (2007) Diet-induced endogenous formation of nitroso compounds in the GI tract. Free Radic Biol Med 43:1040\u20131047. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.03.011","journal-title":"Free Radic Biol Med"},{"key":"3564_CR93","first-page":"2358","volume":"63","author":"AJ Cross","year":"2003","unstructured":"Cross AJ, Pollock JRA, Bingham SA (2003) Haem, not protein or inorganic iron, is responsible for endogenous intestinal n-nitrosation arising from red meat. Cancer Res 63:2358\u20132360","journal-title":"Cancer Res"},{"key":"3564_CR94","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.fct.2018.04.048","volume":"118","author":"C Kruger","year":"2018","unstructured":"Kruger C, Zhou Y (2018) Red meat and colon cancer: a review of mechanistic evidence for heme in the context of risk assessment methodology. Food Chem Toxicol 118:131\u2013153. https:\/\/doi.org\/10.1016\/j.fct.2018.04.048","journal-title":"Food Chem Toxicol"},{"key":"3564_CR95","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1158\/1940-6207.CAPR-10-0113","volume":"4","author":"NM Bastide","year":"2011","unstructured":"Bastide NM, Pierre FHF, Corpet DE (2011) Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved. Cancer Prev Res (Phila Pa) 4:177\u2013184. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-10-0113","journal-title":"Cancer Prev Res (Phila Pa)"},{"key":"3564_CR96","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1158\/1055-9965.EPI-06-0085","volume":"15","author":"F Pierre","year":"2006","unstructured":"Pierre F, Peiro G, Tach\u00e9 S et al (2006) New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol 15:2274\u20132279. https:\/\/doi.org\/10.1158\/1055-9965.EPI-06-0085","journal-title":"Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol"},{"key":"3564_CR97","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01809","author":"M Constante","year":"2017","unstructured":"Constante M, Fragoso G, Calv\u00e9 A et al (2017) Dietary heme induces gut dysbiosis, aggravates colitis, and potentiates the development of adenomas in mice. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2017.01809","journal-title":"Front Microbiol"},{"key":"3564_CR98","doi-asserted-by":"publisher","first-page":"9698","DOI":"10.3390\/ijms21249698","volume":"21","author":"DD Haines","year":"2020","unstructured":"Haines DD, Tosaki A (2020) Heme degradation in pathophysiology of and countermeasures to inflammation-associated disease. Int J Mol Sci 21:9698. https:\/\/doi.org\/10.3390\/ijms21249698","journal-title":"Int J Mol Sci"},{"key":"3564_CR99","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.cpt.2023.04.001","volume":"2","author":"R Singhabahu","year":"2024","unstructured":"Singhabahu R, Kodagoda Gamage SM, Gopalan V (2024) Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis. Cancer Pathog Ther 2:65\u201373. https:\/\/doi.org\/10.1016\/j.cpt.2023.04.001","journal-title":"Cancer Pathog Ther"},{"key":"3564_CR100","unstructured":"(2010) Safety of heme iron (blood peptonates) as a source of iron added for nutritional purposes to foods for the general population, including food supplements | EFSA. https:\/\/www.efsa.europa.eu\/en\/efsajournal\/pub\/1585. Accessed 17 Jul 2024"},{"key":"3564_CR101","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1080\/10408398.2021.1982861","volume":"63","author":"Y Huang","year":"2023","unstructured":"Huang Y, Cao D, Chen Z et al (2023) Iron intake and multiple health outcomes: umbrella review. Crit Rev Food Sci Nutr 63:2910\u20132927. https:\/\/doi.org\/10.1080\/10408398.2021.1982861","journal-title":"Crit Rev Food Sci Nutr"},{"key":"3564_CR102","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/carcin\/bgl192","volume":"28","author":"JC Lunn","year":"2007","unstructured":"Lunn JC, Kuhnle G, Mai V et al (2007) The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract. Carcinogenesis 28:685\u2013690. https:\/\/doi.org\/10.1093\/carcin\/bgl192","journal-title":"Carcinogenesis"},{"key":"3564_CR103","unstructured":"IARC (2018) Red Meat and Processed Meat IARC Monographs on the Evaluation of Carcinogenic Risks to Humans."},{"key":"3564_CR104","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1182\/hematology.2019000034","volume":"2019","author":"S Ning","year":"2019","unstructured":"Ning S, Zeller MP (2019) Management of iron deficiency. Hematology 2019:315\u2013322. https:\/\/doi.org\/10.1182\/hematology.2019000034","journal-title":"Hematology"},{"key":"3564_CR105","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1111\/j.1745-4514.2010.00342.x","volume":"34","author":"K-H Park","year":"2010","unstructured":"Park K-H, Kim H-S, Han M-K, Kim U-H (2010) Heme iron polypeptide polymer with high iron content as an ideal iron supplement. J Food Biochem 34:896\u2013904. https:\/\/doi.org\/10.1111\/j.1745-4514.2010.00342.x","journal-title":"J Food Biochem"},{"key":"3564_CR106","doi-asserted-by":"publisher","first-page":"1382940","DOI":"10.1155\/2022\/1382940","volume":"2022","author":"SE Tadesse","year":"2022","unstructured":"Tadesse SE, Zerga AA, Mekonnen TC et al (2022) Burden and determinants of anemia among under-five children in africa: systematic review and meta-analysis. Anemia 2022:1382940. https:\/\/doi.org\/10.1155\/2022\/1382940","journal-title":"Anemia"},{"key":"3564_CR107","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3390\/nu11010183","volume":"11","author":"L Iglesias V\u00e1zquez","year":"2019","unstructured":"Iglesias V\u00e1zquez L, Valera E, Villalobos M et al (2019) Prevalence of anemia in children from latin america and the caribbean and effectiveness of nutritional interventions: systematic review and meta-analysis. Nutrients 11:183. https:\/\/doi.org\/10.3390\/nu11010183","journal-title":"Nutrients"},{"key":"3564_CR108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236449","volume":"15","author":"DR Sunuwar","year":"2020","unstructured":"Sunuwar DR, Singh DR, Chaudhary NK et al (2020) Prevalence and factors associated with anemia among women of reproductive age in seven South and Southeast Asian countries: evidence from nationally representative surveys. PLoS ONE 15:e0236449. https:\/\/doi.org\/10.1371\/journal.pone.0236449","journal-title":"PLoS ONE"},{"key":"3564_CR109","doi-asserted-by":"publisher","DOI":"10.1515\/rams-2023-0128","author":"M Jarz\u0119bski","year":"2023","unstructured":"Jarz\u0119bski M, Wieruszewski M, Ko\u015bci\u0144ski M et al (2023) Heme iron as potential iron fortifier for food application \u2013 characterization by material techniques. Rev Adv Mater Sci. https:\/\/doi.org\/10.1515\/rams-2023-0128","journal-title":"Rev Adv Mater Sci"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-024-03564-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-024-03564-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-024-03564-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T09:26:57Z","timestamp":1739611617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-024-03564-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,21]]},"references-count":109,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["3564"],"URL":"https:\/\/doi.org\/10.1007\/s00394-024-03564-y","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,21]]},"assertion":[{"value":"14 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"51"}}