{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:56:46Z","timestamp":1776963406993,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Sun Yat-sen University Clinical Research 5010 Program","award":["2014008"],"award-info":[{"award-number":["2014008"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170542"],"award-info":[{"award-number":["82170542"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92251307"],"award-info":[{"award-number":["92251307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270544"],"award-info":[{"award-number":["82270544"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Province \u201cPearl River Talent Plan\u201d Innovation and Entrepreneurship Team Project","award":["2019ZT08Y464"],"award-info":[{"award-number":["2019ZT08Y464"]}]},{"name":"National Key Research and Development Program of China","award":["2021YFF0703702"],"award-info":[{"award-number":["2021YFF0703702"]}]},{"name":"National Key Research and Development Program of China","award":["2023YFF1104404"],"award-info":[{"award-number":["2023YFF1104404"]}]},{"name":"Hubei Provincial Natural Science Foundation of China","award":["2023AFD124"],"award-info":[{"award-number":["2023AFD124"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00394-025-03598-w","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T15:46:25Z","timestamp":1741794385000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dietary risk factors in Crohn\u2019s disease and ulcerative colitis: a cohort study with paired healthy relatives as controls"],"prefix":"10.1007","volume":"64","author":[{"given":"Jun","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingjie","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7904-1769","authenticated-orcid":false,"given":"Lixin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"issue":"3","key":"3598_CR1","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.clnu.2022.12.004","volume":"42","author":"SC Bischoff","year":"2023","unstructured":"Bischoff SC, Bager P, Escher J, Forbes A, H\u00e9buterne X, Hvas CL, Joly F, Klek S, Krznaric Z, Ockenga J, Schneider S, Shamir R, Stardelova K, Bender DV, Wierdsma N, Weimann A (2023) ESPEN guideline on Clinical Nutrition in inflammatory bowel disease. Clin Nutr 42(3):352\u2013379. https:\/\/doi.org\/10.1016\/j.clnu.2022.12.004","journal-title":"Clin Nutr"},{"issue":"5","key":"3598_CR2","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1053\/j.gastro.2018.12.002","volume":"156","author":"V Svolos","year":"2019","unstructured":"Svolos V, Hansen R, Nichols B, Quince C, Ijaz UZ, Papadopoulou RT, Edwards CA, Watson D, Alghamdi A, Brejnrod A, Ansalone C, Duncan H, Gervais L, Tayler R, Salmond J, Bolognini D, Klopfleisch R, Gaya DR, Milling S, Russell RK, Gerasimidis K (2019) Treatment of active Crohn\u2019s Disease with an ordinary food-based Diet that replicates exclusive Enteral Nutrition. Gastroenterology 156(5):1354\u20131367e1356. https:\/\/doi.org\/10.1053\/j.gastro.2018.12.002","journal-title":"Gastroenterology"},{"issue":"2","key":"3598_CR3","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/00054725-200502000-00009","volume":"11","author":"N Sakamoto","year":"2005","unstructured":"Sakamoto N, Kono S, Wakai K, Fukuda Y, Satomi M, Shimoyama T, Inaba Y, Miyake Y, Sasaki S, Okamoto K, Kobashi G, Washio M, Yokoyama T, Date C, Tanaka H (2005) Dietary risk factors for inflammatory bowel disease: a multicenter case-control study in Japan. Inflamm Bowel Dis 11(2):154\u2013163. https:\/\/doi.org\/10.1097\/00054725-200502000-00009","journal-title":"Inflamm Bowel Dis"},{"issue":"9","key":"3598_CR4","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1111\/j.1572-0241.2007.01411.x","volume":"102","author":"DK Amre","year":"2007","unstructured":"Amre DK, D\u2019Souza S, Morgan K, Seidman G, Lambrette P, Grimard G, Israel D, Mack D, Ghadirian P, Deslandres C, Chotard V, Budai B, Law L, Levy E, Seidman EG (2007) Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for Crohn\u2019s disease in children. Am J Gastroenterol 102(9):2016\u20132025. https:\/\/doi.org\/10.1111\/j.1572-0241.2007.01411.x","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"3598_CR5","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1038\/ajg.2010.192","volume":"105","author":"P Jantchou","year":"2010","unstructured":"Jantchou P, Morois S, Clavel-Chapelon F, Boutron-Ruault MC, Carbonnel F (2010) Animal protein intake and risk of inflammatory bowel disease: the E3N prospective study. Am J Gastroenterol 105(10):2195\u20132201. https:\/\/doi.org\/10.1038\/ajg.2010.192","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"3598_CR6","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1136\/gutjnl-2013-305304","volume":"63","author":"AN Ananthakrishnan","year":"2014","unstructured":"Ananthakrishnan AN, Khalili H, Konijeti GG, Higuchi LM, de Silva P, Fuchs CS, Willett WC, Richter JM, Chan AT (2014) Long-term intake of dietary fat and risk of ulcerative colitis and Crohn\u2019s disease. Gut 63(5):776\u2013784. https:\/\/doi.org\/10.1136\/gutjnl-2013-305304","journal-title":"Gut"},{"issue":"1","key":"3598_CR7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000121412","volume":"77","author":"AR Hart","year":"2008","unstructured":"Hart AR, Luben R, Olsen A, Tjonneland A, Linseisen J, Nagel G, Berglund G, Lindgren S, Grip O, Key T, Appleby P, Bergmann MM, Boeing H, Hallmans G, Danielsson A, Palmqvist R, Sjodin H, Hagglund G, Overvad K, Palli D, Masala G, Riboli E, Kennedy H, Welch A, Khaw KT, Day N, Bingham S (2008) Diet in the aetiology of ulcerative colitis: a European prospective cohort study. Digestion 77(1):57\u201364. https:\/\/doi.org\/10.1159\/000121412","journal-title":"Digestion"},{"issue":"6","key":"3598_CR8","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1136\/gut.40.6.754","volume":"40","author":"S Reif","year":"1997","unstructured":"Reif S, Klein I, Lubin F, Farbstein M, Hallak A, Gilat T (1997) Pre-illness dietary factors in inflammatory bowel disease. Gut 40(6):754\u2013760. https:\/\/doi.org\/10.1136\/gut.40.6.754","journal-title":"Gut"},{"issue":"5","key":"3598_CR9","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1053\/j.gastro.2013.07.050","volume":"145","author":"AN Ananthakrishnan","year":"2013","unstructured":"Ananthakrishnan AN, Khalili H, Konijeti GG, Higuchi LM, de Silva P, Korzenik JR, Fuchs CS, Willett WC, Richter JM, Chan AT (2013) A prospective study of long-term intake of dietary fiber and risk of Crohn\u2019s disease and ulcerative colitis. Gastroenterology 145(5):970\u2013977. https:\/\/doi.org\/10.1053\/j.gastro.2013.07.050","journal-title":"Gastroenterology"},{"issue":"6","key":"3598_CR10","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/meg.0000000000000330","volume":"27","author":"F Li","year":"2015","unstructured":"Li F, Liu X, Wang W, Zhang D (2015) Consumption of vegetables and fruit and the risk of inflammatory bowel disease: a meta-analysis. Eur J Gastroenterol Hepatol 27(6):623\u2013630. https:\/\/doi.org\/10.1097\/meg.0000000000000330","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"6","key":"3598_CR11","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.jada.2007.03.007","volume":"107","author":"AF Subar","year":"2007","unstructured":"Subar AF, Thompson FE, Potischman N, Forsyth BH, Buday R, Richards D, McNutt S, Hull SG, Guenther PM, Schatzkin A, Baranowski T (2007) Formative research of a quick list for an automated self-administered 24-hour dietary recall. J Am Diet Assoc 107(6):1002\u20131007. https:\/\/doi.org\/10.1016\/j.jada.2007.03.007","journal-title":"J Am Diet Assoc"},{"issue":"4","key":"3598_CR12","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1128\/jb.188.4.1260-1265.2006","volume":"188","author":"S Parche","year":"2006","unstructured":"Parche S, Beleut M, Rezzonico E, Jacobs D, Arigoni F, Titgemeyer F, Jankovic I (2006) Lactose-over-glucose preference in Bifidobacterium longum NCC2705: glcP, encoding a glucose transporter, is subject to lactose repression. J Bacteriol 188(4):1260\u20131265. https:\/\/doi.org\/10.1128\/jb.188.4.1260-1265.2006","journal-title":"J Bacteriol"},{"issue":"6","key":"3598_CR13","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1097\/MPG.0b013e318285e9d8","volume":"56","author":"LJ Virta","year":"2013","unstructured":"Virta LJ, Ashorn M, Kolho KL (2013) Cow\u2019s milk allergy, asthma, and pediatric IBD. J Pediatr Gastroenterol Nutr 56(6):649\u2013651. https:\/\/doi.org\/10.1097\/MPG.0b013e318285e9d8","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"3598_CR14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/00004836-200201000-00009","volume":"34","author":"C von Tirpitz","year":"2002","unstructured":"von Tirpitz C, Kohn C, Steinkamp M, Geerling I, Maier V, M\u00f6ller P, Adler G, Reinshagen M (2002) Lactose intolerance in active Crohn\u2019s disease: clinical value of duodenal lactase analysis. J Clin Gastroenterol 34(1):49\u201353. https:\/\/doi.org\/10.1097\/00004836-200201000-00009","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"3598_CR15","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S1474-4422(17)30408-8","volume":"17","author":"K Augustin","year":"2018","unstructured":"Augustin K, Khabbush A, Williams S, Eaton S, Orford M, Cross JH, Heales SJR, Walker MC, Williams RSB (2018) Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders. Lancet Neurol 17(1):84\u201393. https:\/\/doi.org\/10.1016\/S1474-4422(17)30408-8","journal-title":"Lancet Neurol"},{"issue":"3","key":"3598_CR16","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1136\/gut.47.3.397","volume":"47","author":"JP Segain","year":"2000","unstructured":"Segain JP, de la Raingeard D, Bourreille A, Leray V, Gervois N, Rosales C, Ferrier L, Bonnet C, Blottiere HM, Galmiche JP (2000) Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn\u2019s disease. Gut 47(3):397\u2013403. https:\/\/doi.org\/10.1136\/gut.47.3.397","journal-title":"Gut"},{"key":"3598_CR17","doi-asserted-by":"publisher","unstructured":"Vich Vila A, Imhann F, Collij V, Jankipersadsing SA, Gurry T, Mujagic Z, Kurilshikov A, Bonder MJ, Jiang X, Tigchelaar EF, Dekens J, Peters V, Voskuil MD, Visschedijk MC, van Dullemen HM, Keszthelyi D, Swertz MA, Franke L, Alberts R, Festen EAM, Dijkstra G, Masclee AAM, Hofker MH, Xavier RJ, Alm EJ, Fu J, Wijmenga C, Jonkers D, Zhernakova A, Weersma RK (2018) Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome. Sci Transl Med 10(472). https:\/\/doi.org\/10.1126\/scitranslmed.aap8914","DOI":"10.1126\/scitranslmed.aap8914"},{"key":"3598_CR18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1196\/annals.1323.028","volume":"1055","author":"WE Lands","year":"2005","unstructured":"Lands WE (2005) Dietary fat and health: the evidence and the politics of prevention: careful use of dietary fats can improve life and prevent disease. Ann N Y Acad Sci 1055:179\u2013192. https:\/\/doi.org\/10.1196\/annals.1323.028","journal-title":"Ann N Y Acad Sci"},{"key":"3598_CR19","doi-asserted-by":"publisher","unstructured":"Calder PC (2020) n-3 PUFA and inflammation: from membrane to nucleus and from bench to bedside. The Proceedings of the Nutrition Society 1\u201313. https:\/\/doi.org\/10.1017\/s0029665120007077","DOI":"10.1017\/s0029665120007077"},{"issue":"12","key":"3598_CR20","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1136\/gut.2008.169078","volume":"58","author":"A Tjonneland","year":"2009","unstructured":"Tjonneland A, Overvad K, Bergmann MM, Nagel G, Linseisen J, Hallmans G, Palmqvist R, Sjodin H, Hagglund G, Berglund G, Lindgren S, Grip O, Palli D, Day NE, Khaw KT, Bingham S, Riboli E, Kennedy H, Hart A (2009) Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort study. Gut 58(12):1606\u20131611. https:\/\/doi.org\/10.1136\/gut.2008.169078","journal-title":"Gut"},{"issue":"5","key":"3598_CR21","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1097\/MEG.0b013e3283352d05","volume":"22","author":"S John","year":"2010","unstructured":"John S, Luben R, Shrestha SS, Welch A, Khaw KT, Hart AR (2010) Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study. Eur J Gastroenterol Hepatol 22(5):602\u2013606. https:\/\/doi.org\/10.1097\/MEG.0b013e3283352d05","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"1","key":"3598_CR22","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.clnu.2020.05.010","volume":"40","author":"MJ MacMaster","year":"2021","unstructured":"MacMaster MJ, Damianopoulou S, Thomson C, Talwar D, Stefanowicz F, Catchpole A, Gerasimidis K, Gaya DR (2021) A prospective analysis of micronutrient status in quiescent inflammatory bowel disease. Clin Nutr 40(1):327\u2013331. https:\/\/doi.org\/10.1016\/j.clnu.2020.05.010","journal-title":"Clin Nutr"},{"issue":"5","key":"3598_CR23","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.smim.2016.10.009","volume":"28","author":"L Almeida","year":"2016","unstructured":"Almeida L, Lochner M, Berod L, Sparwasser T (2016) Metabolic pathways in T cell activation and lineage differentiation. Semin Immunol 28(5):514\u2013524. https:\/\/doi.org\/10.1016\/j.smim.2016.10.009","journal-title":"Semin Immunol"},{"issue":"3","key":"3598_CR24","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/eji.201343940","volume":"44","author":"M Schramm","year":"2014","unstructured":"Schramm M, Wiegmann K, Schramm S, Gluschko A, Herb M, Uterm\u00f6hlen O, Kr\u00f6nke M (2014) Riboflavin (vitamin B2) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes. Eur J Immunol 44(3):728\u2013741. https:\/\/doi.org\/10.1002\/eji.201343940","journal-title":"Eur J Immunol"},{"issue":"1","key":"3598_CR25","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1046\/j.1365-2249.1999.00870.x","volume":"116","author":"J Tamura","year":"1999","unstructured":"Tamura J, Kubota K, Murakami H, Sawamura M, Matsushima T, Tamura T, Saitoh T, Kurabayshi H, Naruse T (1999) Immunomodulation by vitamin B12: augmentation of CD8\u2009+\u2009T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol 116(1):28\u201332. https:\/\/doi.org\/10.1046\/j.1365-2249.1999.00870.x","journal-title":"Clin Exp Immunol"},{"key":"3598_CR26","doi-asserted-by":"publisher","unstructured":"Institute of Medicine Panel on Micronutrients (2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. In. National Academies Press (US) Copyright 2001 by the National Academy of Sciences. All rights reserved., Washington (DC). https:\/\/doi.org\/10.17226\/10026","DOI":"10.17226\/10026"},{"issue":"7","key":"3598_CR27","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.4049\/jimmunol.1303245","volume":"192","author":"M Raverdeau","year":"2014","unstructured":"Raverdeau M, Mills KH (2014) Modulation of T cell and innate immune responses by retinoic acid. J Immunol 192(7):2953\u20132958. https:\/\/doi.org\/10.4049\/jimmunol.1303245","journal-title":"J Immunol"},{"issue":"9","key":"3598_CR28","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1002\/ibd.21916","volume":"18","author":"K Gerasimidis","year":"2012","unstructured":"Gerasimidis K, Talwar D, Duncan A, Moyes P, Buchanan E, Hassan K, O\u2019Reilly D, McGrogan P, Edwards CA (2012) Impact of exclusive enteral nutrition on body composition and circulating micronutrients in plasma and erythrocytes of children with active Crohn\u2019s disease. Inflamm Bowel Dis 18(9):1672\u20131681. https:\/\/doi.org\/10.1002\/ibd.21916","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"3598_CR29","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1177\/0148607107031004311","volume":"31","author":"K Vagianos","year":"2007","unstructured":"Vagianos K, Bector S, McConnell J, Bernstein CN (2007) Nutrition assessment of patients with inflammatory bowel disease. JPEN J Parenter Enter Nutr 31(4):311\u2013319. https:\/\/doi.org\/10.1177\/0148607107031004311","journal-title":"JPEN J Parenter Enter Nutr"}],"updated-by":[{"DOI":"10.1007\/s00394-025-03669-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000}}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-025-03598-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-025-03598-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-025-03598-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T15:01:19Z","timestamp":1745247679000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-025-03598-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["3598"],"URL":"https:\/\/doi.org\/10.1007\/s00394-025-03598-w","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00394-025-03669-y","asserted-by":"object"}]},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,12]]},"assertion":[{"value":"19 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00394-025-03669-y","URL":"https:\/\/doi.org\/10.1007\/s00394-025-03669-y","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board of the Six Affiliated Hospital of Sun Yat-sen University (No. 2014ZSLYEC-003-01). The informed consent form was obtained from all participants before the collection of samples.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors disclose no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"123"}}