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In doing so, diet quality should be prioritised. However, factors influencing diet quality in CF have yet to be examined. This study aims to explore relationships between health-related quality of life (HRQoL), demographic and clinical characteristics, and diet quality in adults living with CF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional study of Irish adults with CF. Dietary intake was assessed using three-day food diaries and analysed using the Healthy Eating Index-2020 (HEI-2020) and Diet Quality Index-International (DQI-I), both scored 0\u2013100, with higher scores indicating better diet quality. Patient-reported outcome measure questionnaires collected HRQoL data and symptom status. Data was statistically analysed in SPSS\u00ae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200973 participants (female: 56.2%, age: 35.1\u2009\u00b1\u200910.3 years), 79.4% were taking CFTR modulators. Mean predicted percentage forced expiratory volume (FEV\n                      <jats:sub>1<\/jats:sub>\n                      %) was 78.7\u2009\u00b1\u200924.9%, and median body mass index was 23.9 (4.2) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Mean HEI-2020 and DQI-I scores were 59.3\u2009\u00b1\u200912.4 and 51.2\u2009\u00b1\u20099.8, respectively. Anxiety\/depression symptoms were reported by 43.1% of participants, and 30.6% reported the presence of pain\/discomfort. Bloating in stomach was reported in 68.1% of participants, with 43.1% reporting moderate to severe symptoms. FEV\n                      <jats:sub>1<\/jats:sub>\n                      % and digestive symptoms were independently positive significant predictors of HEI-2020 scores (R\n                      <jats:sup>2<\/jats:sup>\n                      adj\u2009=\u20090.166,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200967,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the modulator era, suboptimal vitality, anxiety \/ depression, and gut symptoms remain prevalent among adults living with CF. Future dietary interventions should aim to improve diet quality and consider incorporating dietary patterns that positively influence the gut microbiome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00394-025-03766-y","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T14:06:15Z","timestamp":1753365975000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interrelationships between diet quality and health-related quality of life in Irish adults living with cystic fibrosis"],"prefix":"10.1007","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4103-1674","authenticated-orcid":false,"given":"Cian","family":"Greaney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Tecklenborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciara","family":"Howlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Cronin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clodagh","family":"Landers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derbhla","family":"O\u2019Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoife","family":"Whiston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Tierney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"issue":"2","key":"3766_CR1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.clnu.2023.12.017","volume":"43","author":"M Wilschanski","year":"2024","unstructured":"Wilschanski M, Munck A, Carrion E, Cipolli M, Collins S, Colombo C et al (2024) ESPEN-ESPGHAN-ECFS guideline on nutrition care for cystic fibrosis. 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