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While severe vitamin B12 deficiency has well known clinical consequences, the relation of holo-TC within the physiological range to various metabolic and lifestyle parameters in the general population is largely unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>We aimed to identify cross-sectional metabolic, lifestyle, and dietary correlates of serum holo-TC in a population-based sample.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Serum holo-TC was measured by electro-chemiluminescence in n\u2009=\u2009788 individuals (44.0% females, age 61.3 [52.8; 70.2] years). Significant metabolic and lifestyle correlates of serum holo-TC were identified in a backward selection process and included in a final linear regression model. We used a validated Food Frequency Questionnaire to determine daily dietary intake of dairy products, eggs, fish and seafood, and meat and meat products. Associations of food group intake with holo-TC were tested in multivariable-adjusted analyses, both continuously by linear regression models and across holo-TC tertiles by ANCOVA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Median serum holo-TC was measured at 83.6 [66.9; 115.2] pmol\/L. We identified a 10% increase in alanine aminotransferase, total cholesterol, diastolic blood pressure, or alcohol consumption to confer a 2.03% [1.46; 2.60], 4.58% [1.79; 7.45], \u22122.66% [\u22124.78; \u22120.48], or \u22120.25% [\u22120.45; \u22120.05] change in serum holo-TC, respectively. Compared to no supplementation, vitamin B complex supplementation conferred 19.59% [9.72; 30.34] and females compared to males showed 11.55% [5.38; 18.08] higher serum holo-TC levels. Furthermore, a higher consumption of dairy products (in males and females) and fish and seafood (in males) was associated with significantly higher levels of serum holo-TC.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Vitamin B complex supplementation, dairy products and fish and seafood were identified as major sources of vitamin B12 uptake being reflected in serum holo-TC. Furthermore, sex, total cholesterol, a biomarker of liver function, diastolic blood pressure, and alcohol consumption were associated with serum holo-TC in the northern German population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00394-025-03789-5","type":"journal-article","created":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T07:35:11Z","timestamp":1756625711000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlates of serum holo-Transcobalamin in the elderly general population"],"prefix":"10.1007","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3305-5629","authenticated-orcid":false,"given":"Paula","family":"St\u00fcrmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike Andreas","family":"Strathmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana Patricia","family":"Liedtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"\u00d6verm\u00f6hle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Rimbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina Susanne","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Lieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"3789_CR1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3390\/nu2030299","volume":"2","author":"F O\u2019Leary","year":"2010","unstructured":"O\u2019Leary F, Samman S (2010) Vitamin B12 in health and disease. 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