{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:12:19Z","timestamp":1791763939835,"version":"4.3.4"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The UK has a high and increasing prevalence of folate deficiency. The decision to start mandatory folic acid fortification has not yet been implemented. Concern has been raised about the effect of high folate on vitamin B12 status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The prevalence of folate deficiency was assessed based on the serum folate concentrations from 47,240 samples collected between August 2023 and January 2025 (provided to us as anonymised data, measured in a UK-based contract laboratory using an immunochemical analyser). In 39,374 individuals, both serum folate and holotranscobalamin (holoTC) (\u2018active\u2019 vitamin B12) concentrations were available, and were used to determine if high folate status had a negative impact on active vitamin B12 concentrations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>For women of reproductive age (16\u201350 y), 72.7% had serum folate concentration lower than 24.3\u00a0nM\/L for protection against neural tube defects. For young adult women (21\u201325 y) this percentage was 85.5%. The top decile, across all samples (mean serum folate\u2009=\u200943.9\u00a0nM\/L, range 38.4\u2013\u2009&gt;\u200945\u00a0nM\/L, n\u2009=\u20093935), had on average also a high holoTC concentration (119.2\u00a0pM\/L) and no increased risk of vitamin B12 deficiency.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Young women are especially a risk of low folate status. We found no evidence that high folate affects vitamin B12 status.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00394-025-03796-6","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T06:37:45Z","timestamp":1757140665000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Folate status shows no relationship with vitamin B12 but reiterates the urgency for folate fortification in the UK"],"prefix":"10.1007","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-051X","authenticated-orcid":false,"given":"Albert","family":"Koulman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Woolley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry S.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"issue":"6","key":"3796_CR1","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/j.ajcnut.2023.10.006","volume":"118","author":"KS Jones","year":"2023","unstructured":"Jones KS, Collins D, Meadows SR, Koulman A, Page P (2023) National diet and nutrition survey data reveal a decline in folate status in the United Kingdom population between 2008 and 2019. Am J Clin Nutr 118(6):1182\u20131191. https:\/\/doi.org\/10.1016\/j.ajcnut.2023.10.006","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"3796_CR2","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.ajcnut.2023.01.016","volume":"117","author":"A Fothergill","year":"2023","unstructured":"Fothergill A, Crider KS, Rose CE, Bose B, Guetterman HM, Johnson CB, Jabbar S, Zhang M, Pfeiffer CM, Qi YP, Williams JL, Kuriyan R, Bonam W, Finkelstein JL (2023) Estimating the serum folate concentration that corresponds to the red blood cell folate concentration threshold associated with optimal neural tube defects prevention: a population-based biomarker survey in Southern India. 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Eur J Clin Nutr 57(2):349\u2013357. https:\/\/doi.org\/10.1038\/sj.ejcn.1601540","journal-title":"Eur J Clin Nutr"},{"issue":"12","key":"3796_CR11","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1017\/S1368980013003352","volume":"17","author":"GK Pot","year":"2014","unstructured":"Pot GK, Richards M, Prynne CJ, Stephen AM (2014) Development of the eating choices index (ECI): a four-item index to measure healthiness of diet. Public Health Nutr 17(12):2660\u20132666. https:\/\/doi.org\/10.1017\/S1368980013003352","journal-title":"Public Health Nutr"},{"issue":"7","key":"3796_CR12","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/bdra.20468","volume":"82","author":"SL Boulet","year":"2008","unstructured":"Boulet SL, Yang Q, Mai C, Kirby RS, Collins JS, Robbins JM, Meyer R, Canfield MA, Mulinare J, National Birth Defects Prevention Network (2008) Trends in the postfortification prevalence of spina bifida and anencephaly in the United States. 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MMWR Morb Mortal Wkly Rep 64(1):1\u20135"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-025-03796-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-025-03796-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-025-03796-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:13:34Z","timestamp":1760501614000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-025-03796-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["3796"],"URL":"https:\/\/doi.org\/10.1007\/s00394-025-03796-6","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"17 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"T Woolley (TW) was employed by Inuvi Diagnostics. TW did not at any time receive payment or services from a third party (government, commercial, private foundation, etc.) for any aspect of the submitted work (including but not limited to grants, data monitoring board, study design, manuscript preparation, statistical analysis etc.). No other conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"272"}}