{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:12:43Z","timestamp":1783696363654,"version":"3.55.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:00:00Z","timestamp":1780704000000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Metabolic syndrome (MetS) is a multifactorial disorder characterized by metabolic alterations that increase cardiovascular risk and may accelerate telomere attrition, potentially contributing to age-related diseases. Dietary (poly)phenols (PPs), including those derived from blueberries (BB), may counteract telomere shortening through their multitarget biological effects; however, additional mechanistic studies are required. This study investigated the effects of BB-derived PP metabolites, ferulic acid (FA), isoferulic acid (IA), vanillic acid (VA), and hippuric acid (HA), on telomere length (TL) in an in vitro MetS model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The MetS model was established using THP-1 monocytes exposed to free fatty acids and TNF-\u03b1. Metabolites were tested individually and in combination (MIX) at physiologically relevant concentrations (0.1\u201350\u00a0\u00b5M). Cytotoxicity, telomere length, and intracellular reactive oxygen species (ROS) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The MetS stimulus significantly reduced TL (mean difference\u2009\u2212\u20090.61; 95% CI\u2009\u2212\u20090.80 to\u2009\u2212\u20090.41;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Pre-treatment with FA (1\u00a0\u00b5M), VA (0.5\u20135\u00a0\u00b5M), and MIX (6.1\u00a0\u00b5M) significantly attenuated telomere attrition, restoring TL compared to the control (mean differences 0.30\u20130.37;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), whereas lower concentrations of FA, IA, and HA were ineffective. ROS modulation was context-dependent: PP metabolites did not directly affect basal ROS levels but modified the response to H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      exposure, with VA (5\u00a0\u00b5M) and the MIX (6.1\u00a0\u00b5M) exacerbating H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      -induced ROS generation under MetS conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate that selected BB-derived PP metabolites could mitigate telomere shortening under metabolic stress independently of acute ROS modulation, supporting a potential role of dietary PPs in preserving genomic integrity under MetS-like conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00394-026-04010-x","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T12:49:25Z","timestamp":1780750165000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wild blueberry-derived polyphenol metabolites attenuate telomere shortening in an in vitro model of metabolic syndrome"],"prefix":"10.1007","volume":"65","author":[{"given":"Marco","family":"Rendine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Del Bo\u2019","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Riso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"4010_CR1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","volume":"7","author":"J Guo","year":"2022","unstructured":"Guo J, Huang X, Dou L et al (2022) Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal Transduct Target Ther 7:391. https:\/\/doi.org\/10.1038\/s41392-022-01251-0","journal-title":"Signal Transduct Target Ther"},{"key":"4010_CR2","doi-asserted-by":"publisher","first-page":"168060","DOI":"10.1016\/j.bbadis.2025.168060","volume":"1872","author":"L Abo Qoura","year":"2026","unstructured":"Abo Qoura L, Churov AV, Maltseva ON et al (2026) The aging interactome: from cellular dysregulation to therapeutic frontiers in age-related diseases. Biochim Biophys Acta BBA Mol Basis Dis 1872:168060. https:\/\/doi.org\/10.1016\/j.bbadis.2025.168060","journal-title":"Biochim Biophys Acta BBA Mol Basis Dis"},{"key":"4010_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1021\/acschemneuro.3c00531","volume":"15","author":"R Tenchov","year":"2024","unstructured":"Tenchov R, Sasso JM, Wang X, Zhou QA (2024) Aging hallmarks and progression and age-related diseases: a landscape view of research advancement. ACS Chem Neurosci 15:1\u201330. https:\/\/doi.org\/10.1021\/acschemneuro.3c00531","journal-title":"ACS Chem Neurosci"},{"key":"4010_CR4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.dnarep.2014.07.001","volume":"22","author":"B Yousefi","year":"2014","unstructured":"Yousefi B, Samadi N, Ahmadi Y (2014) Akt and p53R2, partners that dictate the progression and invasiveness of cancer. DNA Repair 22:24\u201329. https:\/\/doi.org\/10.1016\/j.dnarep.2014.07.001","journal-title":"DNA Repair"},{"key":"4010_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.molcel.2005.02.035","volume":"18","author":"AJ Sfeir","year":"2005","unstructured":"Sfeir AJ, Chai W, Shay JW, Wright WE (2005) Telomere-end processing. Mol Cell 18:131\u2013138. https:\/\/doi.org\/10.1016\/j.molcel.2005.02.035","journal-title":"Mol Cell"},{"key":"4010_CR6","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/nrm2233","volume":"8","author":"J Campisi","year":"2007","unstructured":"Campisi J, d\u2019Adda Di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8:729\u2013740. https:\/\/doi.org\/10.1038\/nrm2233","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4010_CR7","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.18632\/aging.100413","volume":"3","author":"R Tacutu","year":"2011","unstructured":"Tacutu R, Budovsky A, Yanai H, Fraifeld VE (2011) Molecular links between cellular senescence, longevity and age-related diseases\u2014a systems biology perspective. Aging Albany NY 3:1178\u20131191. https:\/\/doi.org\/10.18632\/aging.100413","journal-title":"Aging Albany NY"},{"key":"4010_CR8","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.3390\/nu10121942","volume":"10","author":"E Balan","year":"2018","unstructured":"Balan E, Decottignies A, Deldicque L (2018) Physical activity and nutrition: two promising strategies for telomere maintenance? Nutrients 10:1942. https:\/\/doi.org\/10.3390\/nu10121942","journal-title":"Nutrients"},{"key":"4010_CR9","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3390\/nu2121231","volume":"2","author":"R Tsao","year":"2010","unstructured":"Tsao R (2010) Chemistry and biochemistry of dietary polyphenols. Nutrients 2:1231\u20131246. https:\/\/doi.org\/10.3390\/nu2121231","journal-title":"Nutrients"},{"key":"4010_CR10","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3390\/molecules21070901","volume":"21","author":"E Brglez Mojzer","year":"2016","unstructured":"Brglez Mojzer E, Knez Hrn\u010di\u010d M, \u0160kerget M et al (2016) Polyphenols: extraction methods, antioxidative action, bioavailability and anticarcinogenic effects. Molecules 21:901. https:\/\/doi.org\/10.3390\/molecules21070901","journal-title":"Molecules"},{"key":"4010_CR11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/genes7090058","volume":"7","author":"J-K Yeh","year":"2016","unstructured":"Yeh J-K, Wang C-Y (2016) Telomeres and telomerase in cardiovascular diseases. Genes 7:58. https:\/\/doi.org\/10.3390\/genes7090058","journal-title":"Genes"},{"key":"4010_CR12","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/1753944717711379","volume":"11","author":"Y Rochlani","year":"2017","unstructured":"Rochlani Y, Pothineni NV, Kovelamudi S, Mehta JL (2017) Metabolic syndrome: pathophysiology, management, and modulation by natural compounds. Ther Adv Cardiovasc Dis 11:215\u2013225. https:\/\/doi.org\/10.1177\/1753944717711379","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"4010_CR13","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","volume":"120","author":"KGMM Alberti","year":"2009","unstructured":"Alberti KGMM, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation 120:1640\u20131645. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.192644","journal-title":"Circulation"},{"key":"4010_CR14","doi-asserted-by":"publisher","first-page":"1390198","DOI":"10.3389\/fgene.2024.1390198","volume":"15","author":"S Ibraheem Shelash Al-Hawary","year":"2024","unstructured":"Ibraheem Shelash Al-Hawary S, Ali Alzahrani A, Ghaleb Maabreh H et al (2024) The association of metabolic syndrome with telomere length as a marker of cellular aging: a systematic review and meta-analysis. Front Genet 15:1390198. https:\/\/doi.org\/10.3389\/fgene.2024.1390198","journal-title":"Front Genet"},{"key":"4010_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41556-022-00842-x","volume":"24","author":"F Rossiello","year":"2022","unstructured":"Rossiello F, Jurk D, Passos JF, d\u2019Adda Di Fagagna F (2022) Telomere dysfunction in ageing and age-related diseases. Nat Cell Biol 24:135\u2013147. https:\/\/doi.org\/10.1038\/s41556-022-00842-x","journal-title":"Nat Cell Biol"},{"key":"4010_CR16","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.3390\/nu11061355","volume":"11","author":"C Del Bo\u2019","year":"2019","unstructured":"Del Bo\u2019 C, Bernardi S, Marino M et al (2019) Systematic review on polyphenol intake and health outcomes: Is there sufficient evidence to define a health-promoting polyphenol-rich dietary pattern? Nutrients 11:1355. https:\/\/doi.org\/10.3390\/nu11061355","journal-title":"Nutrients"},{"key":"4010_CR17","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s13679-025-00656-6","volume":"14","author":"M Rendine","year":"2025","unstructured":"Rendine M, Marino M, Martini D et al (2025) Effect of (Poly)phenols on lipid and glucose metabolisms in 3T3-L1 adipocytes: an integrated analysis of mechanistic approaches. Curr Obes Rep 14:64. https:\/\/doi.org\/10.1007\/s13679-025-00656-6","journal-title":"Curr Obes Rep"},{"key":"4010_CR18","doi-asserted-by":"publisher","first-page":"4327","DOI":"10.1002\/ptr.70062","volume":"39","author":"J Rzemieniec","year":"2025","unstructured":"Rzemieniec J, Marino M, Mercuriali B et al (2025) Modulation of miRNAs by phytochemicals in cerebral ischemia: a systematic review of in vitro and in vivo studies. Phytother Res 39:4327\u20134347. https:\/\/doi.org\/10.1002\/ptr.70062","journal-title":"Phytother Res"},{"key":"4010_CR19","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.3390\/antiox11071224","volume":"11","author":"A Varesi","year":"2022","unstructured":"Varesi A, Chirumbolo S, Campagnoli LIM et al (2022) The role of antioxidants in the interplay between oxidative stress and senescence. Antioxidants 11:1224. https:\/\/doi.org\/10.3390\/antiox11071224","journal-title":"Antioxidants"},{"key":"4010_CR20","doi-asserted-by":"publisher","first-page":"118341","DOI":"10.1016\/j.lfs.2020.118341","volume":"259","author":"M Maleki","year":"2020","unstructured":"Maleki M, Khelghati N, Alemi F et al (2020) Stabilization of telomere by the antioxidant property of polyphenols: anti-aging potential. Life Sci 259:118341. https:\/\/doi.org\/10.1016\/j.lfs.2020.118341","journal-title":"Life Sci"},{"key":"4010_CR21","doi-asserted-by":"publisher","first-page":"7387","DOI":"10.1039\/D3FO00835E","volume":"14","author":"M Marino","year":"2023","unstructured":"Marino M, Venturi S, Rendine M et al (2023) Wild blueberry (V. angustifolium) improves TNF\u03b1-induced cell barrier permeability through claudin-1 and oxidative stress modulation in Caco-2 cells. Food Funct 14:7387\u20137399. https:\/\/doi.org\/10.1039\/D3FO00835E","journal-title":"Food Funct"},{"key":"4010_CR22","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1021\/jf903472x","volume":"58","author":"C Del Bo'","year":"2010","unstructured":"Del Bo\u2019 C, Ciappellano S, Klimis-Zacas D et al (2010) Anthocyanin absorption, metabolism, and distribution from a wild blueberry-enriched diet (Vaccinium angustifolium) is affected by diet duration in the Sprague\u2212Dawley rat. J Agric Food Chem 58:2491\u20132497. https:\/\/doi.org\/10.1021\/jf903472x","journal-title":"J Agric Food Chem"},{"key":"4010_CR23","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1093\/advances\/nmab137","volume":"13","author":"L Felgus-Lavefve","year":"2022","unstructured":"Felgus-Lavefve L, Howard L, Adams SH, Baum JI (2022) The effects of blueberry phytochemicals on cell models of inflammation and oxidative stress. Adv Nutr 13:1279\u20131309. https:\/\/doi.org\/10.1093\/advances\/nmab137","journal-title":"Adv Nutr"},{"key":"4010_CR24","doi-asserted-by":"publisher","first-page":"e70101","DOI":"10.1002\/mnfr.70101","volume":"69","author":"S Venturi","year":"2025","unstructured":"Venturi S, Rendine M, Marino M et al (2025) Differential effects of wild blueberry (poly)phenol metabolites in modulating lipid metabolism and oxidative stress in 3T3-L1 adipocytes. Mol Nutr Food Res 69:e70101. https:\/\/doi.org\/10.1002\/mnfr.70101","journal-title":"Mol Nutr Food Res"},{"key":"4010_CR25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1474-9726.2006.00192.x","volume":"5","author":"MA Wilson","year":"2006","unstructured":"Wilson MA, Shukitt-Hale B, Kalt W et al (2006) Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 5:59\u201368. https:\/\/doi.org\/10.1111\/j.1474-9726.2006.00192.x","journal-title":"Aging Cell"},{"key":"4010_CR26","doi-asserted-by":"publisher","first-page":"3972","DOI":"10.1021\/jf404565s","volume":"62","author":"AN Carey","year":"2014","unstructured":"Carey AN, Gomes SM, Shukitt-Hale B (2014) Blueberry supplementation improves memory in middle-aged mice fed a high-fat diet. J Agric Food Chem 62:3972\u20133978. https:\/\/doi.org\/10.1021\/jf404565s","journal-title":"J Agric Food Chem"},{"key":"4010_CR27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/antiox5040044","volume":"5","author":"A Stull","year":"2016","unstructured":"Stull A (2016) Blueberries\u2019 impact on insulin resistance and glucose intolerance. Antioxidants Basel 5:44. https:\/\/doi.org\/10.3390\/antiox5040044","journal-title":"Antioxidants Basel"},{"key":"4010_CR28","doi-asserted-by":"publisher","first-page":"1151891","DOI":"10.1016\/j.foodres.2024.115189","volume":"197","author":"M Tucci","year":"2024","unstructured":"Tucci M, Del Bo\u2019 C, Martini D et al (2024) A serving of blueberry (Vaccinium corymbosum) improves peripheral vascular function but not metabolic and functional markers in older subjects: a randomized, controlled, crossover study. Food Res Int 197:1151891. https:\/\/doi.org\/10.1016\/j.foodres.2024.115189","journal-title":"Food Res Int"},{"key":"4010_CR29","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s00394-012-0402-9","volume":"52","author":"P Riso","year":"2013","unstructured":"Riso P, Klimis-Zacas D, Del Bo\u2019 C et al (2013) Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors. Eur J Nutr 52:949\u2013961. https:\/\/doi.org\/10.1007\/s00394-012-0402-9","journal-title":"Eur J Nutr"},{"key":"4010_CR30","doi-asserted-by":"publisher","first-page":"109154","DOI":"10.1016\/j.jnutbio.2022.109154","volume":"111","author":"D Martini","year":"2023","unstructured":"Martini D, Marino M, Venturi S et al (2023) Blueberries and their bioactives in the modulation of oxidative stress, inflammation and cardio\/vascular function markers: a systematic review of human intervention studies. J Nutr Biochem 111:109154. https:\/\/doi.org\/10.1016\/j.jnutbio.2022.109154","journal-title":"J Nutr Biochem"},{"key":"4010_CR31","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s11010-021-04313-z","volume":"477","author":"P T\u00fcrck","year":"2022","unstructured":"T\u00fcrck P, Nemec-Bakk A, Talwar T et al (2022) Blueberry extract attenuates norepinephrine-induced oxidative stress and apoptosis in H9c2 cardiac cells. Mol Cell Biochem 477:663\u2013672. https:\/\/doi.org\/10.1007\/s11010-021-04313-z","journal-title":"Mol Cell Biochem"},{"key":"4010_CR32","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1002\/mnfr.201600178","volume":"60","author":"C Del Bo\u2019","year":"2016","unstructured":"Del Bo\u2019 C, Roursgaard M, Porrini M et al (2016) Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF\u2010\u03b1 stimulated proinflammatory environment. Mol Nutr Food Res 60:2355\u20132366. https:\/\/doi.org\/10.1002\/mnfr.201600178","journal-title":"Mol Nutr Food Res"},{"key":"4010_CR33","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.intimp.2014.08.002","volume":"23","author":"W Chanput","year":"2014","unstructured":"Chanput W, Mes JJ, Wichers HJ (2014) THP-1 cell line: An in vitro cell model for immune modulation approach. Int Immunopharmacol 23:37\u201345. https:\/\/doi.org\/10.1016\/j.intimp.2014.08.002","journal-title":"Int Immunopharmacol"},{"key":"4010_CR34","doi-asserted-by":"publisher","first-page":"4112","DOI":"10.3390\/ijms20174112","volume":"20","author":"A Hasan","year":"2019","unstructured":"Hasan A, Akhter N, Al-Roub A et al (2019) TNF-\u03b1 in combination with Palmitate enhances IL-8 production via the MyD88-independent TLR4 signaling pathway: potential relevance to metabolic inflammation. Int J Mol Sci 20:4112. https:\/\/doi.org\/10.3390\/ijms20174112","journal-title":"Int J Mol Sci"},{"key":"4010_CR35","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3945\/ajcn.113.066639","volume":"98","author":"A Rodriguez-Mateos","year":"2013","unstructured":"Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T et al (2013) Intake and time dependence of blueberry flavonoid\u2013induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr 98:1179\u20131191. https:\/\/doi.org\/10.3945\/ajcn.113.066639","journal-title":"Am J Clin Nutr"},{"key":"4010_CR36","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1016\/j.ajcnut.2023.03.017","volume":"117","author":"E Wood","year":"2023","unstructured":"Wood E, Hein S, Mesnage R et al (2023) Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial. Am J Clin Nutr 117:1306\u20131319. https:\/\/doi.org\/10.1016\/j.ajcnut.2023.03.017","journal-title":"Am J Clin Nutr"},{"key":"4010_CR37","doi-asserted-by":"publisher","first-page":"1700405","DOI":"10.1002\/mnfr.201700405","volume":"61","author":"S Zhong","year":"2017","unstructured":"Zhong S, Sandhu A, Edirisinghe I, Burton\u2010Freeman B (2017) Characterization of wild blueberry polyphenols bioavailability and kinetic profile in plasma over 24\u2010h period in human subjects. Mol Nutr Food Res 61:1700405. https:\/\/doi.org\/10.1002\/mnfr.201700405","journal-title":"Mol Nutr Food Res"},{"key":"4010_CR38","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.toxlet.2020.01.002","volume":"322","author":"Y Ma","year":"2020","unstructured":"Ma Y, Bellini N, Scholten RH et al (2020) Effect of combustion-derived particles on genotoxicity and telomere length: a study on human cells and exposed populations. Toxicol Lett 322:20\u201331. https:\/\/doi.org\/10.1016\/j.toxlet.2020.01.002","journal-title":"Toxicol Lett"},{"key":"4010_CR39","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3390\/molecules30030467","volume":"30","author":"A Magiera","year":"2025","unstructured":"Magiera A, Ko\u0142odziejczyk-Czepas J, Olszewska MA (2025) Antioxidant and anti-inflammatory effects of vanillic acid in human plasma, human neutrophils, and non-cellular models in vitro. Molecules 30:467. https:\/\/doi.org\/10.3390\/molecules30030467","journal-title":"Molecules"},{"key":"4010_CR40","first-page":"4310","volume":"124","author":"X-B Wang","year":"2011","unstructured":"Wang X-B, Zhu L, Huang J et al (2011) Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells. Chin Med J (Engl) 124:4310\u20134315","journal-title":"Chin Med J (Engl)"},{"key":"4010_CR41","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ijcard.2011.07.083","volume":"162","author":"R Sheng","year":"2013","unstructured":"Sheng R, Gu Z-L, Xie M-L (2013) Epigallocatechin gallate, the major component of polyphenols in green tea, inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy. Int J Cardiol 162:199\u2013209. https:\/\/doi.org\/10.1016\/j.ijcard.2011.07.083","journal-title":"Int J Cardiol"},{"key":"4010_CR42","doi-asserted-by":"publisher","first-page":"73","DOI":"10.31989\/ffhd.v11i3.775","volume":"11","author":"A Pointner","year":"2021","unstructured":"Pointner A, M\u00f6lzer C, Magnet U et al (2021) The green tea polyphenol EGCG is differentially associated with telomeric regulation in normal human fibroblasts versus cancer cells. Funct Foods Health Dis 11:73. https:\/\/doi.org\/10.31989\/ffhd.v11i3.775","journal-title":"Funct Foods Health Dis"},{"key":"4010_CR43","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4161\/oxim.3.1.9940","volume":"3","author":"S Makpol","year":"2010","unstructured":"Makpol S, Abidin AZ, Sairin K et al (2010) \u03b3-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. Oxid Med Cell Longev 3:35\u201343. https:\/\/doi.org\/10.4161\/oxim.3.1.9940","journal-title":"Oxid Med Cell Longev"},{"key":"4010_CR44","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1093\/advances\/nmaa079","volume":"11","author":"S Canudas","year":"2020","unstructured":"Canudas S, Becerra-Tom\u00e1s N, Hern\u00e1ndez-Alonso P et al (2020) Mediterranean diet and telomere length: a systematic review and meta-analysis. Adv Nutr 11:1544\u20131554. https:\/\/doi.org\/10.1093\/advances\/nmaa079","journal-title":"Adv Nutr"},{"key":"4010_CR45","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1186\/s12967-023-04321-1","volume":"21","author":"W Xing","year":"2023","unstructured":"Xing W, Gao W, Zhao Z et al (2023) Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset. J Transl Med 21:492. https:\/\/doi.org\/10.1186\/s12967-023-04321-1","journal-title":"J Transl Med"},{"key":"4010_CR46","doi-asserted-by":"publisher","first-page":"g6674","DOI":"10.1136\/bmj.g6674","volume":"349","author":"M Crous-Bou","year":"2014","unstructured":"Crous-Bou M, Fung TT, Prescott J et al (2014) Mediterranean diet and telomere length in nurses\u2019 health study: population based cohort study. BMJ 349:g6674\u2013g6674. https:\/\/doi.org\/10.1136\/bmj.g6674","journal-title":"BMJ"},{"key":"4010_CR47","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/j.clnu.2017.05.005","volume":"37","author":"Y Gong","year":"2018","unstructured":"Gong Y, Tian G, Xue H et al (2018) Higher adherence to the \u2018vegetable-rich\u2019 dietary pattern is related to longer telomere length in women. Clin Nutr 37:1232\u20131237. https:\/\/doi.org\/10.1016\/j.clnu.2017.05.005","journal-title":"Clin Nutr"},{"key":"4010_CR48","doi-asserted-by":"publisher","first-page":"8346","DOI":"10.1021\/jf502180j","volume":"62","author":"V Taverniti","year":"2014","unstructured":"Taverniti V, Fracassetti D, Del Bo\u2019 C et al (2014) Immunomodulatory effect of a wild blueberry anthocyanin-rich extract in human Caco-2 intestinal cells. J Agric Food Chem 62:8346\u20138351. https:\/\/doi.org\/10.1021\/jf502180j","journal-title":"J Agric Food Chem"},{"key":"4010_CR49","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","volume":"27","author":"T Von Zglinicki","year":"2002","unstructured":"Von Zglinicki T (2002) Oxidative stress shortens telomeres. Trends Biochem Sci 27:339\u2013344. https:\/\/doi.org\/10.1016\/S0968-0004(02)02110-2","journal-title":"Trends Biochem Sci"},{"key":"4010_CR50","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mad.2018.03.013","volume":"177","author":"RP Barnes","year":"2019","unstructured":"Barnes RP, Fouquerel E, Opresko PL (2019) The impact of oxidative DNA damage and stress on telomere homeostasis. Mech Ageing Dev 177:37\u201345. https:\/\/doi.org\/10.1016\/j.mad.2018.03.013","journal-title":"Mech Ageing Dev"},{"key":"4010_CR51","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3390\/antiox10040507","volume":"10","author":"R Meccariello","year":"2021","unstructured":"Meccariello R, D\u2019Angelo S (2021) Impact of polyphenolic-food on longevity: an elixir of life. An overview. Antioxidants 10:507. https:\/\/doi.org\/10.3390\/antiox10040507","journal-title":"Antioxidants"},{"key":"4010_CR52","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.3390\/antiox12122086","volume":"12","author":"S D\u2019Angelo","year":"2023","unstructured":"D\u2019Angelo S (2023) Diet and aging: the role of polyphenol-rich diets in slow down the shortening of telomeres: a review. Antioxidants 12:2086. https:\/\/doi.org\/10.3390\/antiox12122086","journal-title":"Antioxidants"},{"key":"4010_CR53","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.fitote.2011.01.018","volume":"82","author":"D Proch\u00e1zkov\u00e1","year":"2011","unstructured":"Proch\u00e1zkov\u00e1 D, Bou\u0161ov\u00e1 I, Wilhelmov\u00e1 N (2011) Antioxidant and prooxidant properties of flavonoids. Fitoterapia 82:513\u2013523. https:\/\/doi.org\/10.1016\/j.fitote.2011.01.018","journal-title":"Fitoterapia"},{"key":"4010_CR54","doi-asserted-by":"publisher","first-page":"11199","DOI":"10.1039\/c1cp20722a","volume":"13","author":"A Galano","year":"2011","unstructured":"Galano A, Francisco-M\u00e1rquez M, Alvarez-Idaboy JR (2011) Mechanism and kinetics studies on the antioxidant activity of sinapinic acid. Phys Chem Chem Phys 13:11199. https:\/\/doi.org\/10.1039\/c1cp20722a","journal-title":"Phys Chem Chem Phys"},{"key":"4010_CR55","doi-asserted-by":"publisher","first-page":"40753","DOI":"10.1038\/srep40753","volume":"7","author":"FU Amin","year":"2017","unstructured":"Amin FU, Shah SA, Kim MO (2017) Vanillic acid attenuates A\u03b21-42-induced oxidative stress and cognitive impairment in mice. Sci Rep 7:40753. https:\/\/doi.org\/10.1038\/srep40753","journal-title":"Sci Rep"},{"key":"4010_CR56","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ejphar.2004.07.107","volume":"499","author":"Y-Z Hou","year":"2004","unstructured":"Hou Y-Z, Yang J, Zhao G-R, Yuan Y-J (2004) Ferulic acid inhibits vascular smooth muscle cell proliferation induced by angiotensin II. Eur J Pharmacol 499:85\u201390. https:\/\/doi.org\/10.1016\/j.ejphar.2004.07.107","journal-title":"Eur J Pharmacol"},{"key":"4010_CR57","first-page":"478","volume":"18","author":"W-C Lin","year":"2015","unstructured":"Lin W-C, Peng Y-F, Hou C-W (2015) Ferulic acid protects PC12 neurons against hypoxia by inhibiting the p-MAPKs and COX-2 pathways. Iran J Basic Med Sci 18:478\u2013484","journal-title":"Iran J Basic Med Sci"},{"key":"4010_CR58","doi-asserted-by":"publisher","first-page":"5615","DOI":"10.3390\/ijms26125615","volume":"26","author":"A Kowalska-Baron","year":"2025","unstructured":"Kowalska-Baron A (2025) Theoretical insight into antioxidant mechanisms of trans-isoferulic acid in aqueous medium at different pH. Int J Mol Sci 26:5615. https:\/\/doi.org\/10.3390\/ijms26125615","journal-title":"Int J Mol Sci"},{"key":"4010_CR59","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3390\/antiox9090783","volume":"9","author":"B Sun","year":"2020","unstructured":"Sun B, Wang X, Liu X et al (2020) Hippuric Acid promotes renal fibrosis by disrupting redox homeostasis via facilitation of NRF2\u2013KEAP1\u2013CUL3 interactions in chronic kidney disease. Antioxidants 9:783. https:\/\/doi.org\/10.3390\/antiox9090783","journal-title":"Antioxidants"},{"key":"4010_CR60","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s40168-025-02102-0","volume":"13","author":"Q Ni","year":"2025","unstructured":"Ni Q, Xia L, Huang Y et al (2025) Gut microbiota dysbiosis orchestrates vitiligo-related oxidative stress through the metabolite hippuric acid. Microbiome 13:112. https:\/\/doi.org\/10.1186\/s40168-025-02102-0","journal-title":"Microbiome"},{"key":"4010_CR61","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.3390\/nu13051458","volume":"13","author":"X Palma","year":"2021","unstructured":"Palma X, Thomas-Vald\u00e9s S, Cruz G (2021) Acute consumption of blueberries and short-term blueberry supplementation improve glucose management and insulin levels in sedentary subjects. Nutrients 13:1458. https:\/\/doi.org\/10.3390\/nu13051458","journal-title":"Nutrients"},{"key":"4010_CR62","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1550-2783-9-19","volume":"9","author":"Y McLeay","year":"2012","unstructured":"McLeay Y, Barnes MJ, Mundel T et al (2012) Effect of New Zealand blueberry consumption on recovery from eccentric exercise-induced muscle damage. J Int Soc Sports Nutr 9:19. https:\/\/doi.org\/10.1186\/1550-2783-9-19","journal-title":"J Int Soc Sports Nutr"},{"key":"4010_CR63","doi-asserted-by":"publisher","first-page":"4118","DOI":"10.1039\/C7FO00815E","volume":"8","author":"AR Nair","year":"2017","unstructured":"Nair AR, Mariappan N, Stull AJ, Francis J (2017) Blueberry supplementation attenuates oxidative stress within monocytes and modulates immune cell levels in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Food Funct 8:4118\u20134128. https:\/\/doi.org\/10.1039\/C7FO00815E","journal-title":"Food Funct"},{"key":"4010_CR64","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.nutres.2012.12.009","volume":"33","author":"C Del Bo\u2032","year":"2013","unstructured":"Del Bo\u2032 C, Riso P, Campolo J et al (2013) A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers. Nutr Res 33:220\u2013227. https:\/\/doi.org\/10.1016\/j.nutres.2012.12.009","journal-title":"Nutr Res"},{"key":"4010_CR65","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1039\/C8FO01997E","volume":"10","author":"CG Fraga","year":"2019","unstructured":"Fraga CG, Croft KD, Kennedy DO, Tom\u00e1s-Barber\u00e1n FA (2019) The effects of polyphenols and other bioactives on human health. Food Funct 10:514\u2013528. https:\/\/doi.org\/10.1039\/C8FO01997E","journal-title":"Food Funct"},{"key":"4010_CR66","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.freeradbiomed.2010.04.016","volume":"49","author":"E Niki","year":"2010","unstructured":"Niki E (2010) Assessment of antioxidant capacity in vitro and in vivo. Free Radic Biol Med 49:503\u2013515. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.04.016","journal-title":"Free Radic Biol Med"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-026-04010-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-026-04010-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-026-04010-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:16:07Z","timestamp":1783692967000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-026-04010-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["4010"],"URL":"https:\/\/doi.org\/10.1007\/s00394-026-04010-x","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"6 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"157"}}