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The beverages phenolic profile was analyzed. Anthropometry, body composition, food intake, biochemicals, total plasma antioxidant capacity, oxidative stress, blood metabolite, fecal pH, short-chain fatty acids concentration, and Bristol stool scale were assessed at baseline and endpoint.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sorghum beverage exhibited high diversity of phenolic compounds, including phenolic acids, flavonoids, and tannins, which reflected in higher plasma concentrations of\n                      <jats:italic>trans<\/jats:italic>\n                      -caffeic acid and naringenin in SG at the endpoint compared to the CG, along with an increase in total plasma antioxidant capacity. In the SG, superoxide dismutase and malondialdehyde decreased in intra-group, while catalase decreased at delta. In contrast, CG decreased nitric oxide levels and increased body fat percentage in intra-group. SG decreased insulin, triglycerides, HOMA-IR, and TyG index intra-group, maintaining body fat percentage; increased HDL-c and decreased Castelli I index at the endpoint; and decreased Castelli II index at delta. SG also decreased fecal pH and increased acetic acid content at endpoint and delta.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings support the functional potential of extruded BRS305 sorghum-based beverage in improving fecal and blood metabolites, oxidative balance and cardiometabolic markers in adults with excess body weight.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00394-026-04019-2","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:49:27Z","timestamp":1781866167000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenolic-rich extruded BRS 305 sorghum-based beverage improves fecal and blood metabolites, oxidative balance and cardiometabolic markers in adults with excess body weight: a single-blind, randomized, placebo-controlled study"],"prefix":"10.1007","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-4988","authenticated-orcid":false,"given":"Lucimar Aguiar","family":"da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Parzanini Brilhante","family":"de S\u00e3o Jos\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro Luiz Miranda","family":"Piermatei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Arruda","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietra Vidal Cardoso","family":"do Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Celi Lopes","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Wanderlei Piler","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Aparecida Vieira","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Pereira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Francis","family":"Pierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9rcia Stampini Duarte","family":"Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"4019_CR1","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1002\/ejhf.3539","volume":"27","author":"Z Wu","year":"2024","unstructured":"Wu Z, Xia F, Wang W, Zhang K, Fan M, Lin H (2024) The global burden of disease attributable to high body mass index in 204 countries and territories: Findings from 1990 to 2021 and predictions to 2050. 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