{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:48:58Z","timestamp":1789678138435,"version":"4.0.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["(DIETARY DEAL, ref. AC21\/00038)"],"award-info":[{"award-number":["(DIETARY DEAL, ref. AC21\/00038)"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Nutr"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00394-026-04047-y","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:07:22Z","timestamp":1783076842000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Urinary carnosine links diet quality with one-carbon and lipid metabolism: insights from an interpretive framework for imidazole metabolites"],"prefix":"10.1007","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3597-9234","authenticated-orcid":false,"given":"J.","family":"Tom\u00e9-Carneiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Cepeda-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vald\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieves R.","family":"Col\u00e1s-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fern\u00e1ndez-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bernal \u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mat\u00eda-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alfredo","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"issue":"1","key":"4047_CR1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1373\/clinchem.2017.272344","volume":"64","author":"M Guasch-Ferr\u00e9","year":"2018","unstructured":"Guasch-Ferr\u00e9 M, Bhupathiraju SN, Hu FB (2018) Use of metabolomics in improving assessment of dietary intake. Clin Chem 64(1):82\u201398. https:\/\/doi.org\/10.1373\/clinchem.2017.272344","journal-title":"Clin Chem"},{"issue":"D1","key":"4047_CR2","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa M, Furumichi M, Sato Y, Matsuura Y, Ishiguro-Watanabe M (2025) KEGG: biological systems database as a model of the real world. Nucleic Acids Res 53(D1):D672\u2013D677. https:\/\/doi.org\/10.1093\/nar\/gkae909","journal-title":"Nucleic Acids Res"},{"issue":"Suppl 1","key":"4047_CR3","doi-asserted-by":"publisher","first-page":"2570S","DOI":"10.1093\/jn\/nxaa079","volume":"150","author":"ME Brosnan","year":"2020","unstructured":"Brosnan ME, Brosnan JT (2020) Histidine metabolism and function. J Nutr 150(Suppl 1):2570S-2575S. https:\/\/doi.org\/10.1093\/jn\/nxaa079","journal-title":"J Nutr"},{"key":"4047_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12263-018-0603-9","volume":"13","author":"LO Dragsted","year":"2018","unstructured":"Dragsted LO, Gao Q, Scalbert A et al (2018) Validation of biomarkers of food intake-critical assessment of candidate biomarkers. Genes Nutr 13:14. https:\/\/doi.org\/10.1186\/s12263-018-0603-9","journal-title":"Genes Nutr"},{"key":"4047_CR5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12263-017-0587-x","volume":"12","author":"Q Gao","year":"2017","unstructured":"Gao Q, Pratic\u00f2 G, Scalbert A, Verg\u00e8res G, Kolehmainen M, Manach C et al (2017) A scheme for a flexible classification of dietary and health biomarkers. Genes Nutr 12:34. https:\/\/doi.org\/10.1186\/s12263-017-0587-x","journal-title":"Genes Nutr"},{"issue":"4","key":"4047_CR6","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1152\/physrev.00039.2012","volume":"93","author":"AA Boldyrev","year":"2013","unstructured":"Boldyrev AA, Aldini G, Derave W (2013) Physiology and pathophysiology of carnosine. Physiol Rev 93(4):1803\u20131845. https:\/\/doi.org\/10.1152\/physrev.00039.2012","journal-title":"Physiol Rev"},{"issue":"1","key":"4047_CR7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00726-018-2667-7","volume":"51","author":"A Boldyrev","year":"2019","unstructured":"Boldyrev A, Fedorova T, Stepanova M et al (2019) Carnosine as an effective neuroprotector in brain pathology and potential neuromodulator in normal conditions. Amino Acids 51(1):139\u2013150. https:\/\/doi.org\/10.1007\/s00726-018-2667-7","journal-title":"Amino Acids"},{"issue":"730","key":"4047_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2022.109397","volume":"15","author":"R Fadaei","year":"2022","unstructured":"Fadaei R, Davies SS (2022) Oxidative modification of HDL by lipid peroxidation products impacts HDL function. Arch Biochem Biophys 15(730):109397. https:\/\/doi.org\/10.1016\/j.abb.2022.109397","journal-title":"Arch Biochem Biophys"},{"issue":"10170","key":"4047_CR9","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0140-6736(18)31788-4","volume":"393","author":"W Willett","year":"2019","unstructured":"Willett W, Rockstr\u00f6m J, Loken B et al (2019) Food in the anthropocene: the EAT-Lancet Commission on healthy diets from sustainable food systems. Lancet 393(10170):447\u2013492. https:\/\/doi.org\/10.1016\/S0140-6736(18)31788-4","journal-title":"Lancet"},{"issue":"3","key":"4047_CR10","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa004","volume":"41","author":"M Bl\u00fcher","year":"2020","unstructured":"Bl\u00fcher M (2020) Metabolically healthy obesity. Endocr Rev 41(3):bnaa004. https:\/\/doi.org\/10.1210\/endrev\/bnaa004","journal-title":"Endocr Rev"},{"issue":"2","key":"4047_CR11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s13679-020-00375-0","volume":"9","author":"A Tsatsoulis","year":"2020","unstructured":"Tsatsoulis A, Paschou SA (2020) Metabolically healthy obesity: criteria, epidemiology, controversies, and consequences. Curr Obes Rep 9(2):109\u2013120. https:\/\/doi.org\/10.1007\/s13679-020-00375-0","journal-title":"Curr Obes Rep"},{"issue":"16","key":"4047_CR12","doi-asserted-by":"publisher","first-page":"6466","DOI":"10.1021\/jf070078h","volume":"55","author":"J Ey","year":"2007","unstructured":"Ey J, Sch\u00f6mig E, Taubert D (2007) Dietary sources and antioxidant effects of ergothioneine. J Agric Food Chem 55(16):6466\u20136474. https:\/\/doi.org\/10.1021\/jf070078h","journal-title":"J Agric Food Chem"},{"issue":"20","key":"4047_CR13","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.1002\/1873-3468.13123","volume":"592","author":"B Halliwell","year":"2018","unstructured":"Halliwell B, Cheah IK, Tang RMY (2018) Ergothioneine\u2014a diet-derived antioxidant with therapeutic potential. FEBS Lett 592(20):3357\u20133366. https:\/\/doi.org\/10.1002\/1873-3468.13123","journal-title":"FEBS Lett"},{"issue":"233","key":"4047_CR14","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.foodchem.2017.04.109","volume":"1","author":"MD Kalaras","year":"2017","unstructured":"Kalaras MD, Richie JP, Calcagnotto A, Beelman RB (2017) Mushrooms: a rich source of the antioxidants ergothioneine and glutathione. Food Chem 1(233):429\u2013433. https:\/\/doi.org\/10.1016\/j.foodchem.2017.04.109","journal-title":"Food Chem"},{"key":"4047_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101868","volume":"42","author":"IK Cheah","year":"2021","unstructured":"Cheah IK, Halliwell B (2021) Ergothioneine, recent developments. Redox Biol 42:101868. https:\/\/doi.org\/10.1016\/j.redox.2021.101868","journal-title":"Redox Biol"},{"issue":"1","key":"4047_CR16","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0021-9258(18)71313-6","volume":"206","author":"DB Melville","year":"1954","unstructured":"Melville DB, Horner WH, Lubschez R (1954) Tissue ergothioneine. J Biol Chem 206(1):221\u2013228","journal-title":"J Biol Chem"},{"issue":"8079","key":"4047_CR17","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41586-025-09263-w","volume":"645","author":"A Mastrangelo","year":"2025","unstructured":"Mastrangelo A, Robles-Vera I, Ma\u00f1anes D et al (2025) Imidazole propionate is a driver and therapeutic target in atherosclerosis. Nature 645(8079):254\u2013261. https:\/\/doi.org\/10.1038\/s41586-025-09263-w","journal-title":"Nature"},{"issue":"5","key":"4047_CR18","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1161\/ATVBAHA.124.322346","volume":"45","author":"V Nageswaran","year":"2025","unstructured":"Nageswaran V, Carreras A, Reinshagen L et al (2025) Gut microbial metabolite imidazole propionate impairs endothelial cell function and promotes the development of atherosclerosis. Arterioscler Thromb Vasc Biol 45(5):823\u2013839. https:\/\/doi.org\/10.1161\/ATVBAHA.124.322346","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4047_CR19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf661","author":"FA Wenzl","year":"2025","unstructured":"Wenzl FA, Wang P, Kahles F et al (2025) Gut microbiota-derived imidazole propionate predicts cardiometabolic risk in patients with coronary artery disease. Eur Heart J. https:\/\/doi.org\/10.1093\/eurheartj\/ehaf661","journal-title":"Eur Heart J"},{"issue":"6","key":"4047_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15060348","volume":"15","author":"E Fern\u00e1ndez-Cruz","year":"2025","unstructured":"Fern\u00e1ndez-Cruz E, de la O V, Fern\u00e1ndez-Diaz CM, Mat\u00eda-Mart\u00edn P, Rubio-Herrera M\u00c1, Amig\u00f3 N, Calle-Pascual AL, Mart\u00ednez JA (2025) Urinary hippuric acid as a sex-dependent biomarker for fruit and nut intake raised from the EAT-Lancet index and nuclear magnetic resonance analysis. Metabolites 15(6):348. https:\/\/doi.org\/10.3390\/metabo15060348","journal-title":"Metabolites"},{"issue":"3","key":"4047_CR21","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1093\/ajcn\/nqab369","volume":"115","author":"A Stubbendorff","year":"2022","unstructured":"Stubbendorff A, Sonestedt E, Ramne S, Drake I, Hallstr\u00f6m E, Ericson U (2022) Development of an EAT-Lancet index and its relation to mortality in a Swedish population. Am J Clin Nutr 115(3):705\u2013716. https:\/\/doi.org\/10.1093\/ajcn\/nqab369","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"4047_CR22","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150(9):604\u2013612. https:\/\/doi.org\/10.7326\/0003-4819-150-9-200905050-00006","journal-title":"Ann Intern Med"},{"issue":"6","key":"4047_CR23","doi-asserted-by":"publisher","first-page":"371","DOI":"10.2165\/00126839-200506060-00005","volume":"6","author":"R Corc\u00f3stegui","year":"2005","unstructured":"Corc\u00f3stegui R, Labeaga L, Inner\u00e1rity A, Berisa A, Orjales A (2005) Preclinical pharmacology of bilastine, a new selective histamine H1 receptor antagonist: receptor selectivity and in vitro functional studies. Drugs R D 6(6):371\u2013384. https:\/\/doi.org\/10.2165\/00126839-200506060-00005","journal-title":"Drugs R D"},{"issue":"D1","key":"4047_CR24","doi-asserted-by":"publisher","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","volume":"46","author":"DS Wishart","year":"2018","unstructured":"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale V, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M (2018) DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res 46(D1):D1074\u2013D1082. https:\/\/doi.org\/10.1093\/nar\/gkx1037","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"4047_CR25","doi-asserted-by":"publisher","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","volume":"51","author":"S Kim","year":"2023","unstructured":"Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, Zaslavsky L, Zhang J, Bolton EE (2023) PubChem 2023 update. Nucleic Acids Res 51(D1):D1373\u2013D1380. https:\/\/doi.org\/10.1093\/nar\/gkac956","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"4047_CR26","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1080\/10408398.2022.2114006","volume":"64","author":"EM Brouwer-Brolsma","year":"2024","unstructured":"Brouwer-Brolsma EM, Brennan L, Drevon CA et al (2024) Towards nutrition with precision: unlocking biomarkers as dietary assessment tools. Crit Rev Food Sci Nutr 64(5):1139\u20131176. https:\/\/doi.org\/10.1080\/10408398.2022.2114006","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"9","key":"4047_CR27","doi-asserted-by":"publisher","first-page":"6107","DOI":"10.1016\/S0021-9258(18)88943-8","volume":"260","author":"RL Sabina","year":"1985","unstructured":"Sabina RL, Patterson D, Holmes EW (1985) 5-Amino-4-imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells. J Biol Chem 260(9):6107\u20136114","journal-title":"J Biol Chem"},{"issue":"1","key":"4047_CR28","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1146\/annurev.nutr.012809.104810","volume":"30","author":"AS Tibbetts","year":"2010","unstructured":"Tibbetts AS, Appling DR (2010) Compartmentalization of mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr 30(1):57\u201381. https:\/\/doi.org\/10.1146\/annurev.nutr.012809.104810","journal-title":"Annu Rev Nutr"},{"issue":"1","key":"4047_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3926","volume":"42","author":"S Dang","year":"2024","unstructured":"Dang S, Jain A, Dhanda G et al (2024) One carbon metabolism and its implication in health and immune functions. Cell Biochem Funct 42(1):e3926. https:\/\/doi.org\/10.1002\/cbf.3926","journal-title":"Cell Biochem Funct"},{"issue":"1","key":"4047_CR30","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B Stat Methodol 57(1):289\u2013300","journal-title":"J R Stat Soc Ser B Stat Methodol"},{"key":"4047_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s12263-019-0656-4","volume":"14","author":"C Cuparencu","year":"2019","unstructured":"Cuparencu C, Pratic\u00f2 G, Hemeryck LY et al (2019) Biomarkers of meat and seafood intake: an extensive literature review. Genes Nutr 14:35. https:\/\/doi.org\/10.1186\/s12263-019-0656-4","journal-title":"Genes Nutr"},{"key":"4047_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1461331","volume":"12","author":"G La Barbera","year":"2024","unstructured":"La Barbera G, Pratic\u00f2 G, Dragsted LO, Cuparencu C (2024) Metabolomics-based biomarkers of fermented dairy and red meat intake: a randomized controlled trial in healthy adults. Front Chem 12:1461331. https:\/\/doi.org\/10.3389\/fchem.2024.1461331","journal-title":"Front Chem"},{"key":"4047_CR33","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/s41430-018-0248-1","volume":"73","author":"P Mitry","year":"2019","unstructured":"Mitry P, Wawro N, Rohrmann S et al (2019) Plasma concentrations of anserine, carnosine and pi-methylhistidine as biomarkers of habitual meat consumption. Eur J Clin Nutr 73:692\u2013702. https:\/\/doi.org\/10.1038\/s41430-018-0248-1","journal-title":"Eur J Clin Nutr"},{"issue":"9","key":"4047_CR34","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","volume":"18","author":"S Salminen","year":"2021","unstructured":"Salminen S, Collado MC, Endo A et al (2021) The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol 18(9):649\u2013667. https:\/\/doi.org\/10.1038\/s41575-021-00440-6","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"22","key":"4047_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25225465","volume":"25","author":"M Garbowska","year":"2020","unstructured":"Garbowska M, Pluta A, Berthold-Pluta A (2020) Contents of functionally bioactive peptides, free amino acids, and biogenic amines in Dutch-type cheese models produced with different lactobacilli. Molecules 25(22):5465. https:\/\/doi.org\/10.3390\/molecules25225465","journal-title":"Molecules"},{"key":"4047_CR36","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00394-020-02216-0","volume":"60","author":"C Cuparencu","year":"2021","unstructured":"Cuparencu C, Rinnan \u00c5, Hendriks MMWB et al (2021) Combining untargeted and untargeted metabolomics with imidazole-focused analysis to assess the plasma metabolome in relation to short-term and habitual dietary patterns: a randomized controlled cross-over trial. Eur J Clin Nutr 60:179\u2013192. https:\/\/doi.org\/10.1007\/s00394-020-02216-0","journal-title":"Eur J Clin Nutr"},{"issue":"12","key":"4047_CR37","doi-asserted-by":"publisher","first-page":"9346","DOI":"10.1074\/jbc.M109.095505","volume":"285","author":"J Drozak","year":"2010","unstructured":"Drozak J, Veiga-da-Cunha M, Vertommen D, Stroobant V, Van Schaftingen E (2010) Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1). J Biol Chem 285(12):9346\u20139356. https:\/\/doi.org\/10.1074\/jbc.M109.095505","journal-title":"J Biol Chem"},{"issue":"9","key":"4047_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092867","volume":"12","author":"P Lyon","year":"2020","unstructured":"Lyon P, Strippoli V, Fang B, Cimmino L (2020) B vitamins and one-carbon metabolism: implications in human health and disease. Nutrients 12(9):2867. https:\/\/doi.org\/10.3390\/nu12092867","journal-title":"Nutrients"},{"key":"4047_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000518489","volume":"15","author":"TL LeVatte","year":"2022","unstructured":"LeVatte TL, Keshteli AH, Zarei M, Wishart DS (2022) Applications of metabolomics to precision nutrition. Lifestyle Genom 15:1\u20139. https:\/\/doi.org\/10.1159\/000518489","journal-title":"Lifestyle Genom"},{"key":"4047_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102808","volume":"65","author":"L Brennan","year":"2023","unstructured":"Brennan L, de Roos B (2023) Role of metabolomics in the delivery of precision nutrition. Redox Biol 65:102808. https:\/\/doi.org\/10.1016\/j.redox.2023.102808","journal-title":"Redox Biol"},{"issue":"5","key":"4047_CR41","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1586\/17512433.2013.827403","volume":"6","author":"AG Phimister","year":"2013","unstructured":"Phimister AG, Thorn CF, Klein TE, Altman RB (2013) Davunetide: a review of safety and efficacy data with a focus on neurodegenerative diseases. Expert Rev Clin Pharmacol 6(5):485\u2013493. https:\/\/doi.org\/10.1586\/17512433.2013.827403","journal-title":"Expert Rev Clin Pharmacol"},{"key":"4047_CR42","doi-asserted-by":"publisher","DOI":"10.1007\/s42452-019-1485-1","volume":"1","author":"A Sharma","year":"2019","unstructured":"Sharma A, Kumar V, Shahzad B et al (2019) Worldwide pesticide usage and its impacts on ecosystem. SN Appl Sci 1:1446. https:\/\/doi.org\/10.1007\/s42452-019-1485-1","journal-title":"SN Appl Sci"},{"key":"4047_CR43","volume-title":"Pesticide residues in food\u20141998 evaluations","author":"FAO\/WHO Joint Meeting on Pesticide Residues","year":"1998","unstructured":"FAO\/WHO Joint Meeting on Pesticide Residues (1998) Carbendazim. Pesticide residues in food\u20141998 evaluations. Food and Agriculture Organization of the United Nations, Rome"},{"issue":"2","key":"4047_CR44","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1021\/acs.est.4c08615","volume":"59","author":"S Xu","year":"2025","unstructured":"Xu S, Li Y, Zhang Q et al (2025) Carbendazim exposure aggravates gut inflammation through microbiome dysbiosis and metabolic reprogramming. Environ Sci Technol 59(2):2473\u20132483. https:\/\/doi.org\/10.1021\/acs.est.4c08615","journal-title":"Environ Sci Technol"}],"container-title":["European Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-026-04047-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00394-026-04047-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00394-026-04047-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:15:00Z","timestamp":1787058900000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00394-026-04047-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["4047"],"URL":"https:\/\/doi.org\/10.1007\/s00394-026-04047-y","relation":{},"ISSN":["1436-6207","1436-6215"],"issn-type":[{"value":"1436-6207","type":"print"},{"value":"1436-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"assertion":[{"value":"16 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this work the authors used Claude.ai (Sonnet 4.5) in order to assist in the decisions regarding the classification framework for urinary imidazole metabolites. After using this tool, the authors reviewed and edited the content as needed and takes full responsibility for the content of the publication.","order":2,"name":"Ethics","label":"Declaration of generative AI and AI-assisted technologies in the writing process","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"191"}}