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Participants underwent anthropometric assessment, cardiovascular risk evaluation, dietary assessment, and genotyping using a genomic microarray. Single nucleotide polymorphisms (SNPs) associated with BP changes were identified and used to construct PRSs. Multiple linear regression models were employed to examine associations between PRSs, dietary interventions, and changes in systolic (\u0394SBP) and diastolic BP (\u0394DBP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 114 SNPs were associated with \u0394SBP and 101 with \u0394DBP. The resulting PRSs showed strong correlations with both \u0394SBP (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and \u0394DBP (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.84;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). No significant effect of dietary intervention on BP changes was observed, and no interaction was identified between PRSs and dietary approach for \u0394SBP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.98) or \u0394DBP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.13).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PRSs derived from BP-associated SNPs were strong predictors of BP changes over six months, independent of dietary intervention. These findings support the potential utility of genetic profiling in predicting individual variability in BP response, although replication in independent cohorts is warranted. Main study trial registration number NCT03793881 on ClinicalTrials.gov.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00394-026-04072-x","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:13:28Z","timestamp":1785586408000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polygenic risk scores predict blood pressure changes independent of dietary intervention: a secondary analysis of the NUPRESS trial"],"prefix":"10.1007","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-8639","authenticated-orcid":false,"given":"Luciana C.","family":"Holzbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1994-4610","authenticated-orcid":false,"given":"Aline","family":"Marcadenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-781X","authenticated-orcid":false,"given":"Angela C.","family":"Bersch-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-9144","authenticated-orcid":false,"given":"Rachel H. 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