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This pilot study comprehensively explores the effects of a 3-week ur gut\n                      <jats:sup>\u00ae<\/jats:sup>\n                      supplementation on gut microbiota, gut health, dietary intake, sleep, mental health and quality of life (QOL) in individuals with IBS following a low FODMAP diet.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adult participants (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u200926, 3 males) completed a randomised, double-blind controlled study. Participants were provided with either ur gut\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u200913) or placebo (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u200913) for 3 weeks after a 1-week baseline. At baseline and end of intervention, blood, 24-h faecal samples and 3-day weighed-food diaries were collected. Validated questionnaires were used to evaluate mental health, sleep, QOL and gut symptoms. Participants reported daily IBS symptoms and wore a wrist-based actigraphy to capture daily sleep.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the intervention, both groups maintained baseline stable gut symptoms and sleep patterns. After the intervention, the ur gut\n                      <jats:sup>\u00ae<\/jats:sup>\n                      group had lower energy (\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.05) and protein (\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.01) intake compared to the placebo group, and increased resistant starch intake (\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.001) compared to baseline. Changes in overall genus-level gut microbiota composition (\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.01), including\n                      <jats:italic>Ruminococcus E<\/jats:italic>\n                      (5.5-fold increase,\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.01), were observed. ur gut\n                      <jats:sup>\u00ae<\/jats:sup>\n                      improved GI-specific anxiety (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.01) and sexual subscale of QOL (\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Compared with placebo, ur gut\n                      <jats:sup>\u00ae<\/jats:sup>\n                      increased dietary fibre intake, improved gut microbiota and gastrointestinal-specific anxiety without negatively impacting sleep, despite no changes observed in faecal and blood biomarkers. This provides a dietary strategy to support gut health without compromising symptom control in IBS.\n                    <\/jats:p>\n                    <jats:p>\n                      Australia and New Zealand Clinical Trial Registry\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.anzctr.org.au\/\" ext-link-type=\"uri\">http:\/\/www.anzctr.org.au\/<\/jats:ext-link>\n                      , ACTRN12620000032954.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00394-026-04113-5","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:48:36Z","timestamp":1790254116000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary fibre blend improves gut health in patients with irritable bowel syndrome following a low FODMAP diet: a randomised, double-blind control trial"],"prefix":"10.1007","volume":"65","author":[{"given":"Ran","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Devine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evania","family":"Marlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian C.","family":"Dunican","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanita","family":"Kunaratnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Andrew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus T.","family":"Christophersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"issue":"10","key":"4113_CR1","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/s2468-1253(20)30217-x","volume":"5","author":"P Oka","year":"2020","unstructured":"Oka P, Parr H, Barberio B, Black CJ, Savarino EV, Ford AC (2020) Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis. 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