{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:13:34Z","timestamp":1780694014100,"version":"3.54.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T00:00:00Z","timestamp":1359936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1007\/s00395-013-0332-6","type":"journal-article","created":{"date-parts":[[2013,2,3]],"date-time":"2013-02-03T07:47:55Z","timestamp":1359877675000},"source":"Crossref","is-referenced-by-count":27,"title":["Neuronal nitric oxide synthase is indispensable for the cardiac adaptive effects of exercise"],"prefix":"10.1007","volume":"108","author":[{"given":"Steve R.","family":"Roof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Ostler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthu","family":"Periasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandor","family":"Gy\u00f6rke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Billman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Ziolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,4]]},"reference":[{"key":"332_CR1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/416337a","volume":"416","author":"LA Barouch","year":"2002","unstructured":"Barouch LA, Harrison RW, Skaf MW, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O\u2019Rourke B, Rodriguez ER, Huang PL, Lima JA, Berkowitz DE, Hare JM (2002) Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 416:337\u2013339. doi: 10.1038\/416005a","journal-title":"Nature"},{"key":"332_CR2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00005768-200001000-00012","volume":"32","author":"DR Bassett Jr","year":"2000","unstructured":"Bassett DR Jr, Howley ET (2000) Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med Sci Sports Exerc 32:70\u201384. doi: 10.1097\/00005768-200001000-00012","journal-title":"Med Sci Sports Exerc"},{"key":"332_CR3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.mito.2003.10.001","volume":"3","author":"PS Brookes","year":"2004","unstructured":"Brookes PS (2004) Mitochondrial nitric oxide synthase. Mitochondrion 3:187\u2013204. doi: 10.1016\/j.mito.2003.10.001","journal-title":"Mitochondrion"},{"key":"332_CR4","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1161\/CIRCULATIONAHA.109.933630","volume":"122","author":"N Burkard","year":"2010","unstructured":"Burkard N, Williams T, Czolbe M, Blomer N, Panther F, Link M, Fraccarollo D, Widder JD, Hu K, Han H, Hofmann U, Frantz S, Nordbeck P, Bulla J, Schuh K, Ritter O (2010) Conditional overexpression of neuronal nitric oxide synthase is cardioprotective in ischemia\/reperfusion. Circulation 122:1588\u20131603. doi: 10.1161\/CIRCULATIONAHA.109.933630","journal-title":"Circulation"},{"key":"332_CR5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2741\/2681","volume":"13","author":"D Catalucci","year":"2008","unstructured":"Catalucci D, Latronico MV, Ellingsen O, Condorelli G (2008) Physiological myocardial hypertrophy: how and why? Front Biosci 13:312\u2013324. doi: 10.2741\/2681","journal-title":"Front Biosci"},{"key":"332_CR6","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1113\/jphysiol.2009.183723","volume":"588","author":"SW Copp","year":"2010","unstructured":"Copp SW, Hirai DM, Schwagerl PJ, Musch TI, Poole DC (2010) Effects of neuronal nitric oxide synthase inhibition on resting and exercising hindlimb muscle blood flow in the rat. J Physiol 588:1321\u20131331. doi: 10.1113\/jphysiol.2009.183723","journal-title":"J Physiol"},{"key":"332_CR7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00395-011-0240-6","volume":"107","author":"H Dabire","year":"2012","unstructured":"Dabire H, Barthelemy I, Blanchard-Gutton N, Sambin L, Sampedrano CC, Gouni V, Unterfinger Y, Aguilar P, Thibaud JL, Ghaleh B, Bize A, Pouchelon JL, Blot S, Berdeaux A, Hittinger L, Chetboul V, Su JB (2012) Vascular endothelial dysfunction in Duchenne muscular dystrophy is restored by bradykinin through upregulation of eNOS and nNOS. Basic Res Cardiol 107:240\u2013246. doi: 10.1007\/s00395-011-0240-6","journal-title":"Basic Res Cardiol"},{"key":"332_CR8","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1161\/CIRCULATIONAHA.105.539437","volume":"112","author":"D Dawson","year":"2005","unstructured":"Dawson D, Lygate CA, Zhang MH, Hulbert K, Neubauer S, Casadei B (2005) nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction. Circulation 112:3729\u20133737. doi: 10.1161\/CIRCULATIONAHA.105.539437","journal-title":"Circulation"},{"key":"332_CR9","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1152\/japplphysiol.00282.2010","volume":"109","author":"M Ericsson","year":"2010","unstructured":"Ericsson M, Sjaland C, Andersson KB, Sjaastad I, Christensen G, Sejersted OM, Ellingsen O (2010) Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice. J Appl Physiol 109:1749\u20131755. doi: 10.1152\/japplphysiol.00282.2010","journal-title":"J Appl Physiol"},{"key":"332_CR10","doi-asserted-by":"crossref","first-page":"26677","DOI":"10.1016\/S0021-9258(18)47072-X","volume":"269","author":"ES Furfine","year":"1994","unstructured":"Furfine ES, Harmon MF, Paith JE, Knowles RG, Salter M, Kiff RJ, Duffy C, Hazelwood R, Oplinger JA, Garvey EP (1994) Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-l-thiocitrulline and S-ethyl-l-thiocitrulline. J Biol Chem 269:26677\u201326683. doi: 10.1074\/jbc.273.15.888","journal-title":"J Biol Chem"},{"key":"332_CR11","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.neuropharm.2008.06.058","volume":"55","author":"S Gingerich","year":"2008","unstructured":"Gingerich S, Krukoff TL (2008) Activation of ERbeta increases levels of phosphorylated nNOS and NO production through a Src\/PI3K\/Akt-dependent pathway in hypothalamic neurons. Neuropharmacology 55:878\u2013885. doi: 0.1016\/j.neuropharm.2008.06.058","journal-title":"Neuropharmacology"},{"key":"332_CR12","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1056\/NEJMcibr0806723","volume":"359","author":"LJ Goodyear","year":"2008","unstructured":"Goodyear LJ (2008) The exercise pill\u2014too good to be true? N Engl J Med 359:1842\u20131844. doi: 10.1056\/NEJMcibr0806723","journal-title":"N Engl J Med"},{"key":"332_CR13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00395-010-0146-8","volume":"106","author":"A Guggilam","year":"2011","unstructured":"Guggilam A, Cardinale JP, Mariappan N, Sriramula S, Haque M, Francis J (2011) Central TNF inhibition results in attenuated neurohumoral excitation in heart failure: a role for superoxide and nitric oxide. Basic Res Cardiol 106:273\u2013286. doi: 10.1007\/s00395-010-0146-8","journal-title":"Basic Res Cardiol"},{"key":"332_CR14","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1161\/01.CIR.0000074229.93804.5C","volume":"107","author":"R Hambrecht","year":"2003","unstructured":"Hambrecht R, Adams V, Erbs S, Linke A, Krankel N, Shu Y, Baither Y, Gielen S, Thiele H, Gummert JF, Mohr FW, Schuler G (2003) Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 107:3152\u20133158. doi: 10.1161\/01.CIR.0000074229.93804.5C","journal-title":"Circulation"},{"key":"332_CR15","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1172\/JCI113840","volume":"82","author":"HK Hammond","year":"1988","unstructured":"Hammond HK, Ransnas LA, Insel PA (1988) Noncoordinate regulation of cardiac Gs protein and beta-adrenergic receptors by a physiological stimulus, chronic dynamic exercise. J Clin Invest 82:2168\u20132171. doi: 10.1172\/JCI113840","journal-title":"J Clin Invest"},{"key":"332_CR16","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1161\/CIRCULATIONAHA.108.805242","volume":"118","author":"G Heusch","year":"2008","unstructured":"Heusch G, Boengler K, Schulz R (2008) Cardioprotection: nitric oxide, protein kinases, and mitochondria. Circulation 118:1915\u20131919. doi: 10.1161\/CIRCULATIONAHA.108.805242","journal-title":"Circulation"},{"key":"332_CR17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/01.RES.87.2.146","volume":"87","author":"G Heusch","year":"2000","unstructured":"Heusch G, Post H, Michel MC, Kelm M, Schulz R (2000) Endogenous nitric oxide and myocardial adaptation to ischemia. Circ Res 87:146\u2013152. doi: 10.1161\/01.RES.87.2.146","journal-title":"Circ Res"},{"key":"332_CR18","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/HJR.0b013e3281eacef1","volume":"14","author":"MA Hoydal","year":"2007","unstructured":"Hoydal MA, Wisloff U, Kemi OJ, Ellingsen O (2007) Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training. Eur J Cardiovasc Prev Rehabil 14:753\u2013760. doi: 10.1097\/HJR.0b013e3281eacef1","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"332_CR19","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.bbrc.2004.06.058","volume":"320","author":"K Husain","year":"2004","unstructured":"Husain K (2004) Physical conditioning modulates rat cardiac vascular endothelial growth factor gene expression in nitric oxide-deficient hypertension. Biochem Biophys Res Commun 320:1169\u20131174. doi: 10.1016\/j.bbrc.2004.06.058","journal-title":"Biochem Biophys Res Commun"},{"key":"332_CR20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.yjmcc.2007.08.012","volume":"43","author":"PM Janssen","year":"2007","unstructured":"Janssen PM, Periasamy M (2007) Determinants of frequency-dependent contraction and relaxation of mammalian myocardium. J Mol Cell Cardiol 43:523\u2013531. doi: 10.1016\/j.yjmcc.2007.08.012","journal-title":"J Mol Cell Cardiol"},{"key":"332_CR21","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/01.RES.0000126497.38281.23","volume":"94","author":"S Janssens","year":"2004","unstructured":"Janssens S, Pokreisz P, Schoonjans L, Pellens M, Vermeersch P, Tjwa M, Jans P, Scherrer-Crosbie M, Picard MH, Szelid Z, Gillijns H, Van de Werf F, Collen D, Bloch KD (2004) Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circ Res 94:1256\u20131262. doi: 10.1161\/01.RES.0000126497.38281.23","journal-title":"Circ Res"},{"key":"332_CR22","doi-asserted-by":"crossref","first-page":"H144","DOI":"10.1152\/ajpheart.01278.2008","volume":"297","author":"AN Kavazis","year":"2009","unstructured":"Kavazis AN, Alvarez S, Talbert E, Lee Y, Powers SK (2009) Exercise training induces a cardioprotective phenotype and alterations in cardiac subsarcolemmal and intermyofibrillar mitochondrial proteins. Am J Physiol Heart Circ Physiol 297:H144\u2013H152. doi: 10.1152\/ajpheart.01278.2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"332_CR23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/HJR.0b013e3282efd4e0","volume":"15","author":"OJ Kemi","year":"2008","unstructured":"Kemi OJ, Ceci M, Condorelli G, Smith GL, Wisloff U (2008) Myocardial sarcoplasmic reticulum Ca2+ ATPase function is increased by aerobic interval training. Eur J Cardiovasc Prev Rehabil 15:145\u2013148. doi: 10.1097\/HJR.0b013e3282efd4e0","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"332_CR24","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.yjmcc.2007.06.013","volume":"43","author":"OJ Kemi","year":"2007","unstructured":"Kemi OJ, Ellingsen O, Ceci M, Grimaldi S, Smith GL, Condorelli G, Wisloff U (2007) Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. J Mol Cell Cardiol 43:354\u2013361. doi: 10.1016\/j.yjmcc.2007.06.013","journal-title":"J Mol Cell Cardiol"},{"key":"332_CR25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2741\/2685","volume":"13","author":"OJ Kemi","year":"2008","unstructured":"Kemi OJ, Ellingsen O, Smith GL, Wisloff U (2008) Exercise-induced changes in calcium handling in left ventricular cardiomyocytes. Front Biosci 13:356\u2013368. doi: 10.2741\/2685","journal-title":"Front Biosci"},{"key":"332_CR26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cardiores.2005.03.010","volume":"67","author":"OJ Kemi","year":"2005","unstructured":"Kemi OJ, Haram PM, Loennechen JP, Osnes JB, Skomedal T, Wisloff U, Ellingsen O (2005) Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovasc Res 67:161\u2013172. doi: 10.1016\/j.cardiores.2005.03.010","journal-title":"Cardiovasc Res"},{"key":"332_CR27","doi-asserted-by":"crossref","first-page":"15944","DOI":"10.1073\/pnas.0404136101","volume":"101","author":"SA Khan","year":"2004","unstructured":"Khan SA, Lee K, Minhas KM, Gonzalez DR, Raju SV, Tejani AD, Li D, Berkowitz DE, Hare JM (2004) Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. Proc Natl Acad Sci USA 101:15944\u201315948. doi: 10.1073\/pnas.0404136101","journal-title":"Proc Natl Acad Sci USA"},{"key":"332_CR28","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1161\/01.RES.0000078171.52542.9E","volume":"92","author":"SA Khan","year":"2003","unstructured":"Khan SA, Skaf MW, Harrison RW, Lee K, Minhas KM, Kumar A, Fradley M, Shoukas AA, Berkowitz DE, Hare JM (2003) Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. Circ Res 92:1322\u20131329. doi: 10.1161\/01.RES.0000078171.52542.9E","journal-title":"Circ Res"},{"key":"332_CR29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.RES.0000155331.09458.A7","volume":"96","author":"S Kinugawa","year":"2005","unstructured":"Kinugawa S, Huang H, Wang Z, Kaminski PM, Wolin MS, Hintze TH (2005) A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase. Circ Res 96:355\u2013362. doi: 10.1161\/01.RES.0000155331.09458.A7","journal-title":"Circ Res"},{"key":"332_CR30","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature07414","volume":"456","author":"YM Kobayashi","year":"2008","unstructured":"Kobayashi YM, Rader EP, Crawford RW, Iyengar NK, Thedens DR, Faulkner JA, Parikh SV, Weiss RM, Chamberlain JS, Moore SA, Campbell KP (2008) Sarcolemma-localized nNOS is required to maintain activity after mild exercise. Nature 456:511\u2013515. doi: 10.1038\/nature07414","journal-title":"Nature"},{"key":"332_CR31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.yjmcc.2010.01.007","volume":"48","author":"MJ Kohr","year":"2010","unstructured":"Kohr MJ, Traynham CJ, Roof SR, Davis JP, Ziolo MT (2010) cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes. J Mol Cell Cardiol 48:645\u2013648. doi: 10.1016\/j.yjmcc.2010.01.007","journal-title":"J Mol Cell Cardiol"},{"key":"332_CR32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/cvr\/cvm018","volume":"77","author":"MJ Kohr","year":"2008","unstructured":"Kohr MJ, Wang H, Wheeler DG, Velayutham M, Zweier JL, Ziolo MT (2008) Targeting of phospholamban by peroxynitrite decreases {beta}-adrenergic stimulation in cardiomyocytes. Cardiovasc Res 77:353\u2013361. doi: 10.1093\/cvr\/cvm018","journal-title":"Cardiovasc Res"},{"key":"332_CR33","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1161\/CIRCULATIONAHA.110.948349","volume":"122","author":"P Kokkinos","year":"2010","unstructured":"Kokkinos P, Myers J (2010) Exercise and physical activity: clinical outcomes and applications. Circulation 122:1637\u20131648. doi: 10.1161\/CIRCULATIONAHA.110.948349","journal-title":"Circulation"},{"key":"332_CR34","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1007\/s00421-011-1909-0","volume":"111","author":"JR Libonati","year":"2011","unstructured":"Libonati JR, MacDonnell SM (2011) Cardiac beta-adrenergic responsiveness with exercise. Eur J Appl Physiol 111:2735\u20132741. doi: 10.1007\/s00421-011-1909-0","journal-title":"Eur J Appl Physiol"},{"key":"332_CR35","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1161\/CIRCULATIONAHA.107.741702","volume":"117","author":"X Loyer","year":"2008","unstructured":"Loyer X, Gomez AM, Milliez P, Fernandez-Velasco M, Vangheluwe P, Vinet L, Charue D, Vaudin E, Zhang W, Sainte-Marie Y, Robidel E, Marty I, Mayer B, Jaisser F, Mercadier JJ, Richard S, Shah AM, Benitah JP, Samuel JL, Heymes C (2008) Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling. Circulation 117:3187\u20133198. doi: 10.1161\/CIRCULATIONAHA.107.741702","journal-title":"Circulation"},{"key":"332_CR36","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1161\/CIRCULATIONAHA.104.505784","volume":"111","author":"SM MacDonnell","year":"2005","unstructured":"MacDonnell SM, Kubo H, Crabbe DL, Renna BF, Reger PO, Mohara J, Smithwick LA, Koch WJ, Houser SR, Libonati JR (2005) Improved myocardial beta-adrenergic responsiveness and signaling with exercise training in hypertension. Circulation 111:3420\u20133428. doi: 10.1161\/CIRCULATIONAHA.104.505784","journal-title":"Circulation"},{"key":"332_CR37","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1056\/NEJMoa021067","volume":"347","author":"JE Manson","year":"2002","unstructured":"Manson JE, Greenland P, LaCroix AZ, Stefanick ML, Mouton CP, Oberman A, Perri MG, Sheps DS, Pettinger MB, Siscovick DS (2002) Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med 347:716\u2013725. doi: 10.1056\/NEJMoa021067","journal-title":"N Engl J Med"},{"key":"332_CR38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cardiores.2006.02.002","volume":"70","author":"SR Martin","year":"2006","unstructured":"Martin SR, Emanuel K, Sears CE, Zhang YH, Casadei B (2006) Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation. Cardiovasc Res 70:97\u2013106. doi: 10.1016\/j.cardiores.2006.02.002","journal-title":"Cardiovasc Res"},{"key":"332_CR39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1152\/japplphysiol.00493.2007","volume":"104","author":"A Medeiros","year":"2008","unstructured":"Medeiros A, Rolim NP, Oliveira RS, Rosa KT, Mattos KC, Casarini DE, Irigoyen MC, Krieger EM, Krieger JE, Negrao CE, Brum PC (2008) Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice. J Appl Physiol 104:103\u2013109. doi: 10.1152\/japplphysiol.00493.2007","journal-title":"J Appl Physiol"},{"key":"332_CR40","first-page":"RA209","volume":"15","author":"MK Misra","year":"2009","unstructured":"Misra MK, Sarwat M, Bhakuni P, Tuteja R, Tuteja N (2009) Oxidative stress and ischemic myocardial syndromes. Med Sci Monit 15:RA209\u2013RA219","journal-title":"Med Sci Monit"},{"key":"332_CR41","first-page":"H421","volume":"234","author":"PA Mole","year":"1978","unstructured":"Mole PA (1978) Increased contractile potential of papillary muscles from exercise-trained rat hearts. Am J Physiol 234:H421\u2013H425","journal-title":"Am J Physiol"},{"key":"332_CR42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0008-6363(97)00246-0","volume":"37","author":"T Neumann","year":"1998","unstructured":"Neumann T, Ravens U, Heusch G (1998) Characterization of excitation-contraction coupling in conscious dogs with pacing-induced heart failure. Cardiovasc Res 37:456\u2013466. doi: 10.1016\/S0008-6363(97)00246-0","journal-title":"Cardiovasc Res"},{"key":"332_CR43","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/j.jacc.2011.12.046","volume":"59","author":"X Niu","year":"2012","unstructured":"Niu X, Watts VL, Cingolani OH, Sivakumaran V, Leyton-Mange JS, Ellis CL, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Paolocci N, Kass DA, Barouch LA (2012) Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase. J Am Coll Cardiol 59:1979\u20131987. doi: 10.1016\/j.jacc.2011.12.046","journal-title":"J Am Coll Cardiol"},{"key":"332_CR44","doi-asserted-by":"crossref","first-page":"H2392","DOI":"10.1152\/ajpheart.2001.281.6.H2392","volume":"281","author":"H Post","year":"2001","unstructured":"Post H, Schulz R, Gres P, Heusch G (2001) No involvement of nitric oxide in the limitation of beta-adrenergic inotropic responsiveness during ischemia. Am J Physiol Heart Circ Physiol 281:H2392\u2013H2397","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"332_CR45","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1093\/eurheartj\/ehl096","volume":"27","author":"T Rassaf","year":"2006","unstructured":"Rassaf T, Poll LW, Brouzos P, Lauer T, Totzeck M, Kleinbongard P, Gharini P, Andersen K, Schulz R, Heusch G, Modder U, Kelm M (2006) Positive effects of nitric oxide on left ventricular function in humans. Eur Heart J 27:1699\u20131705. doi: 10.1093\/eurheartj\/ehl096","journal-title":"Eur Heart J"},{"key":"332_CR46","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cmet.2008.07.004","volume":"8","author":"EA Richter","year":"2008","unstructured":"Richter EA, Kiens B, Wojtaszewski JF (2008) Can exercise mimetics substitute for exercise? Cell Metab 8:96\u201398. doi: 10.1016\/j.cmet.2008.07.004","journal-title":"Cell Metab"},{"key":"332_CR47","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.niox.2012.08.077","volume":"27","author":"SR Roof","year":"2012","unstructured":"Roof SR, Biesiadecki BJ, Davis JP, Janssen PM, Ziolo MT (2012) Effects of increased systolic Ca(2+) and beta-adrenergic stimulation on Ca(2+) transient decline in NOS1 knockout cardiac myocytes. Nitric Oxide 27:242\u2013247. doi: 10.1016\/j.niox.2012.08.077","journal-title":"Nitric Oxide"},{"key":"332_CR48","doi-asserted-by":"crossref","first-page":"H1570","DOI":"10.1152\/ajpheart.00402.2011","volume":"301","author":"SR Roof","year":"2011","unstructured":"Roof SR, Shannon TR, Janssen PM, Ziolo MT (2011) Effects of increased systolic Ca2+ and phospholamban phosphorylation during beta-adrenergic stimulation on Ca2+ transient kinetics in cardiac myocytes. Am J Physiol Heart Circ Physiol 301:H1570\u2013H1578. doi: 10.1152\/ajpheart.00402.2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"332_CR49","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1161\/CIRCULATIONAHA.105.557892","volume":"112","author":"RM Saraiva","year":"2005","unstructured":"Saraiva RM, Minhas KM, Raju SV, Barouch LA, Pitz E, Schuleri KH, Vandegaer K, Li D, Hare JM (2005) Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: role of nitroso-redox equilibrium. Circulation 112:3415\u20133422. doi: 10.1161\/CIRCULATIONAHA.105.557892","journal-title":"Circulation"},{"key":"332_CR50","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cardiores.2003.09.019","volume":"61","author":"R Schulz","year":"2004","unstructured":"Schulz R, Kelm M, Heusch G (2004) Nitric oxide in myocardial ischemia\/reperfusion injury. Cardiovasc Res 61:402\u2013413. doi: 10.1016\/j.cardiores.2003.09.019","journal-title":"Cardiovasc Res"},{"key":"332_CR51","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1161\/CIRCULATIONAHA.108.822205","volume":"119","author":"M Seddon","year":"2009","unstructured":"Seddon M, Melikian N, Dworakowski R, Shabeeh H, Jiang B, Byrne J, Casadei B, Chowienczyk P, Shah AM (2009) Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo. Circulation 119:2656\u20132662. doi: 10.1161\/CIRCULATIONAHA.108.822205","journal-title":"Circulation"},{"key":"332_CR52","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1152\/japplphysiol.91280.2008","volume":"106","author":"CH Shao","year":"2009","unstructured":"Shao CH, Wehrens XH, Wyatt TA, Parbhu S, Rozanski GJ, Patel KP, Bidasee KR (2009) Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol 106:1280\u20131292. doi: 10.1152\/japplphysiol.91280.2008","journal-title":"J Appl Physiol"},{"key":"332_CR53","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1152\/jappl.1992.72.1.307","volume":"72","author":"RJ Spina","year":"1992","unstructured":"Spina RJ, Ogawa T, Coggan AR, Holloszy JO, Ehsani AA (1992) Exercise training improves left ventricular contractile response to beta-adrenergic agonist. J Appl Physiol 72:307\u2013311","journal-title":"J Appl Physiol"},{"key":"332_CR54","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1161\/CIRCRESAHA.109.199810","volume":"105","author":"TO Stolen","year":"2009","unstructured":"Stolen TO, Hoydal MA, Kemi OJ, Catalucci D, Ceci M, Aasum E, Larsen T, Rolim N, Condorelli G, Smith GL, Wisloff U (2009) Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circ Res 105:527\u2013536. doi: 10.1161\/CIRCRESAHA.109.199810","journal-title":"Circ Res"},{"key":"332_CR55","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/BF01906747","volume":"80","author":"N Takeda","year":"1985","unstructured":"Takeda N, Dominiak P, Turck D, Rupp H, Jacob R (1985) The influence of endurance training on mechanical catecholamine responsiveness, beta-adrenoceptor density and myosin isoenzyme pattern of rat ventricular myocardium. Basic Res Cardiol 80:88\u201399. doi: 10.1007\/BF01906747","journal-title":"Basic Res Cardiol"},{"key":"332_CR56","doi-asserted-by":"crossref","first-page":"L452","DOI":"10.1152\/ajplung.00270.2002","volume":"284","author":"T Vassilakopoulos","year":"2003","unstructured":"Vassilakopoulos T, Deckman G, Kebbewar M, Rallis G, Harfouche R, Hussain SN (2003) Regulation of nitric oxide production in limb and ventilatory muscles during chronic exercise training. Am J Physiol Lung Cell Mol Physiol 284:L452\u2013L457. doi: 10.1152\/ajplung.00270.2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"332_CR57","doi-asserted-by":"crossref","first-page":"645721","DOI":"10.1155\/2012\/645721","volume":"2012","author":"H Wang","year":"2012","unstructured":"Wang H, Bonilla IM, Huang X, He Q, Kohr MJ, Carnes CA, Ziolo MT (2012) Prolonged action potential and after depolarizations are not due to changes in potassium currents in NOS3 knockout ventricular myocytes. J Signal Transduct 2012:645721. doi: 10.1155\/2012\/645721","journal-title":"J Signal Transduct"},{"key":"332_CR58","doi-asserted-by":"crossref","first-page":"C1566","DOI":"10.1152\/ajpcell.00367.2007","volume":"294","author":"H Wang","year":"2008","unstructured":"Wang H, Kohr MJ, Traynham CJ, Wheeler DG, Janssen PM, Ziolo MT (2008) Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban. Am J Physiol Cell Physiol 294:C1566\u2013C1575. doi: 10.1152\/ajpcell.00367.2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"332_CR59","doi-asserted-by":"crossref","first-page":"H1473","DOI":"10.1152\/ajpheart.01249.2007","volume":"294","author":"H Wang","year":"2008","unstructured":"Wang H, Kohr MJ, Wheeler DG, Ziolo MT (2008) Endothelial nitric oxide synthase decreases beta-adrenergic responsiveness via inhibition of the L-type Ca2+ current. Am J Physiol Heart Circ Physiol 294:H1473\u2013H1480. doi: 10.1152\/ajpheart.01249.2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"332_CR60","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1113\/jphysiol.2010.192617","volume":"588","author":"H Wang","year":"2010","unstructured":"Wang H, Viatchenko-Karpinski S, Sun J, Gyorke I, Benkusky NA, Kohr MJ, Valdivia HH, Murphy E, Gyorke S, Ziolo MT (2010) Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation. J Physiol 588:2905\u20132917. doi: 10.1113\/jphysiol.2010.192617","journal-title":"J Physiol"},{"key":"332_CR61","doi-asserted-by":"crossref","first-page":"H1301","DOI":"10.1152\/ajpheart.2001.280.3.H1301","volume":"280","author":"U Wisloff","year":"2001","unstructured":"Wisloff U, Helgerud J, Kemi OJ, Ellingsen O (2001) Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol 280:H1301\u2013H1310","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"332_CR62","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0008-6363(01)00565-X","volume":"54","author":"U Wisloff","year":"2002","unstructured":"Wisloff U, Loennechen JP, Currie S, Smith GL, Ellingsen O (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovasc Res 54:162\u2013174. doi: 10.1016\/S0008-6363(01)00565-X","journal-title":"Cardiovasc Res"},{"key":"332_CR63","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1161\/CIRCULATIONAHA.106.675041","volume":"115","author":"U Wisloff","year":"2007","unstructured":"Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, Tjonna AE, Helgerud J, Slordahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen O, Skjaerpe T (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 115:3086\u20133094. doi: 10.1161\/CIRCULATIONAHA.106.675041","journal-title":"Circulation"},{"key":"332_CR64","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1113\/jphysiol.2010.197418","volume":"588","author":"KC Yang","year":"2010","unstructured":"Yang KC, Foeger NC, Marionneau C, Jay PY, McMullen JR, Nerbonne JM (2010) Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy. J Physiol 588:5015\u20135032. doi: 10.1113\/jphysiol.2010.197418","journal-title":"J Physiol"},{"key":"332_CR65","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.bbabio.2009.03.020","volume":"1787","author":"YH Zhang","year":"2009","unstructured":"Zhang YH, Dingle L, Hall R, Casadei B (2009) The role of nitric oxide and reactive oxygen species in the positive inotropic response to mechanical stretch in the mammalian myocardium. Biochim Biophys Acta 1787:811\u2013817. doi: 10.1016\/j.bbabio.2009.03.020","journal-title":"Biochim Biophys Acta"},{"key":"332_CR66","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1161\/CIRCRESAHA.107.164798","volume":"102","author":"YH Zhang","year":"2008","unstructured":"Zhang YH, Zhang MH, Sears CE, Emanuel K, Redwood C, El-Armouche A, Kranias EG, Casadei B (2008) Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice. Circ Res 102:242\u2013249. doi: 10.1161\/CIRCRESAHA.107.164798","journal-title":"Circ Res"},{"key":"332_CR67","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1161\/01.RES.0000080783.34092.AF","volume":"92","author":"MT Ziolo","year":"2003","unstructured":"Ziolo MT, Bers DM (2003) The real estate of NOS signaling: location, location, location. Circ Res 92:1279\u20131281. doi: 10.1161\/01.RES.0000080783.34092.AF","journal-title":"Circ Res"},{"key":"332_CR68","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.yjmcc.2008.07.015","volume":"45","author":"MT Ziolo","year":"2008","unstructured":"Ziolo MT, Kohr MJ, Wang H (2008) Nitric oxide signaling and the regulation of myocardial function. J Mol Cell Cardiol 45:625\u2013632. doi: 10.1016\/j.yjmcc.2008.07.015","journal-title":"J Mol Cell Cardiol"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-013-0332-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00395-013-0332-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-013-0332-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T11:27:44Z","timestamp":1644233264000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00395-013-0332-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,4]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["332"],"URL":"https:\/\/doi.org\/10.1007\/s00395-013-0332-6","relation":{},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,4]]},"article-number":"332"}}