{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:21:23Z","timestamp":1786980083483,"version":"build-2736575974"},"reference-count":124,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T00:00:00Z","timestamp":1397779200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1007\/s00395-014-0409-x","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T13:57:58Z","timestamp":1397743078000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["The role of capillary transit time heterogeneity in myocardial oxygenation and ischemic heart disease"],"prefix":"10.1007","volume":"109","author":[{"given":"Leif","family":"\u00d8stergaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Buus","family":"Kristiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Angleys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Fr\u00f8ki\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Michael Hasenkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sune N\u00f8rh\u00f8j","family":"Jespersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Erik","family":"B\u00f8tker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,18]]},"reference":[{"key":"409_CR1","doi-asserted-by":"crossref","unstructured":"Agostini D, Iida H, Takahashi A, Tamura Y, Henry Amar M, Ono Y (2001) Regional myocardial metabolic rate of oxygen measured by O2-15 inhalation and positron emission tomography in patients with cardiomyopathy. Clin Nucl Med 26:41\u201349. doi: 10.1097\/00003072-200101000-00010 . http:\/\/journals.lww.com\/nuclearmed\/Fulltext\/2001\/01000\/Regional_Myocardial_Metabolic_Rate_of_Oxygen.10","DOI":"10.1097\/00003072-200101000-00010"},{"key":"409_CR2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s10016-004-0030-9","volume":"18","author":"G Albaugh","year":"2004","unstructured":"Albaugh G, Bellavance E, Strande L, Heinburger S, Hewitt CW, Alexander JB (2004) Nicotine induces mononuclear leukocyte adhesion and expression of adhesion molecules, VCAM and ICAM, in endothelial cells in vitro. Ann Vasc Surg 18:302\u2013307. doi: 10.1007\/s10016-004-0030-9","journal-title":"Ann Vasc Surg"},{"key":"409_CR3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/01.RES.67.2.319","volume":"67","author":"RE Austin Jr","year":"1990","unstructured":"Austin RE Jr, Aldea GS, Coggins DL, Flynn AE, Hoffman JI (1990) Profound spatial heterogeneity of coronary reserve. Discordance between patterns of resting and maximal myocardial blood flow. Circ Res 67:319\u2013331. doi: 10.1161\/01.RES.67.2.319","journal-title":"Circ Res"},{"key":"409_CR4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/japplphysiol.00879.2002","volume":"94","author":"JC Baldi","year":"2003","unstructured":"Baldi JC, Aoina JL, Oxenham HC, Bagg W, Doughty RN (2003) Reduced exercise arteriovenous O2 difference in type 2 diabetes. J Appl Physiol 94:1033\u20131038. doi: 10.1152\/japplphysiol.00879.2002","journal-title":"J Appl Physiol"},{"key":"409_CR5","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s003950170010","volume":"96","author":"JB Bassingthwaighte","year":"2001","unstructured":"Bassingthwaighte JB, Beard DA, Li Z (2001) The mechanical and metabolic basis of myocardial blood flow heterogeneity. Basic Res Cardiol 96:582\u2013594. doi: 10.1007\/s003950170010","journal-title":"Basic Res Cardiol"},{"key":"409_CR6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1161\/01.RES.65.3.578","volume":"65","author":"JB Bassingthwaighte","year":"1989","unstructured":"Bassingthwaighte JB, King RB, Roger SA (1989) Fractal nature of regional myocardial blood flow heterogeneity. Circ Res 65:578\u2013590. doi: 10.1161\/01.RES.65.3.578","journal-title":"Circ Res"},{"key":"409_CR7","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1161\/01.RES.66.5.1328","volume":"66","author":"JB Bassingthwaighte","year":"1990","unstructured":"Bassingthwaighte JB, Malone MA, Moffett TC, King RB, Chan IS, Link JM, Krohn KA (1990) Molecular and particulate depositions for regional myocardial flows in sheep. Circ Res 66:1328\u20131344. doi: 10.1161\/01.RES.66.5.1328","journal-title":"Circ Res"},{"key":"409_CR8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0026-2862(74)90008-9","volume":"7","author":"JB Bassingthwaighte","year":"1974","unstructured":"Bassingthwaighte JB, Yipintsoi T, Harvey RB (1974) Microvasculature of the dog left ventricular myocardium. Microvasc Res 7:229\u2013249. doi: 10.1016\/0026-2862(74)90008-9","journal-title":"Microvasc Res"},{"key":"409_CR9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","volume":"87","author":"K Bedard","year":"2007","unstructured":"Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87:245\u2013313. doi: 10.1152\/physrev.00044.2005","journal-title":"Physiol Rev"},{"key":"409_CR10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0002-8703(03)00124-8","volume":"146","author":"JF Beltrame","year":"2003","unstructured":"Beltrame JF, Limaye SB, Wuttke RD, Horowitz JD (2003) Coronary hemodynamic and metabolic studies of the coronary slow flow phenomenon. Am Heart J 146:84\u201390. doi: 10.1016\/S0002-8703(03)00124-8","journal-title":"Am Heart J"},{"key":"409_CR11","first-page":"1","volume":"48","author":"HE Botker","year":"2001","unstructured":"Botker HE (2001) Vascular and metabolic abnormalities in patients with angina pectoris and normal coronary angiograms. Dan Med Bull 48:1\u201318","journal-title":"Dan Med Bull"},{"key":"409_CR12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0140-6736(93)91344-L","volume":"342","author":"HE Botker","year":"1993","unstructured":"Botker HE, Moller N, Ovesen P, Mengel A, Schmitz O, Orskov H, Bagger JP (1993) Insulin resistance in microvascular angina (syndrome X). Lancet 342:136\u2013140. doi: 10.1016\/0140-6736(93)91344-L","journal-title":"Lancet"},{"key":"409_CR13","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/S0002-9149(97)00209-9","volume":"79","author":"HE Botker","year":"1997","unstructured":"Botker HE, Sonne HS, Bagger JP, Nielsen TT (1997) Impact of impaired coronary flow reserve and insulin resistance on myocardial energy metabolism in patients with syndrome X. Am J Cardiol 79:1615\u20131622. doi: 10.1016\/S0002-9149(97)00209-9","journal-title":"Am J Cardiol"},{"key":"409_CR14","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1161\/01.CIR.99.14.1795","volume":"99","author":"M Bottcher","year":"1999","unstructured":"Bottcher M, Botker HE, Sonne H, Nielsen TT, Czernin J (1999) Endothelium-dependent and -independent perfusion reserve and the effect of l-arginine on myocardial perfusion in patients with syndrome X. Circulation 99:1795\u20131801. doi: 10.1161\/01.CIR.99.14.1795","journal-title":"Circulation"},{"key":"409_CR15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1083\/jcb.37.2.244","volume":"37","author":"RR Bruns","year":"1968","unstructured":"Bruns RR, Palade GE (1968) Studies on blood capillaries: I. General organization of blood capillaries in muscle. J Cell Biol 37:244\u2013276. doi: 10.1083\/jcb.37.2.244","journal-title":"J Cell Biol"},{"key":"409_CR16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ahj.2004.06.028","volume":"149","author":"D Burkhoff","year":"2005","unstructured":"Burkhoff D, Lefer DJ (2005) Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers. Am Heart J 149:573\u2013579. doi: 10.1016\/j.ahj.2004.06.028","journal-title":"Am Heart J"},{"key":"409_CR17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/cvr\/cvp079","volume":"83","author":"JW Calvert","year":"2009","unstructured":"Calvert JW, Lefer DJ (2009) Myocardial protection by nitrite. Cardiovasc Res 83:195\u2013203. doi: 10.1093\/cvr\/cvp079","journal-title":"Cardiovasc Res"},{"key":"409_CR18","doi-asserted-by":"crossref","unstructured":"Constantinescu AA, Vink H, Spaan JA (2001) Elevated capillary tube hematocrit reflects degradation of endothelial cell glycocalyx by oxidized LDL. Am J Physiol Heart Circ Physiol 280:H1051\u20137. http:\/\/ajpheart.physiology.org\/content\/280\/3\/H1051.full-text.pdf","DOI":"10.1152\/ajpheart.2001.280.3.H1051"},{"key":"409_CR19","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1161\/01.RES.53.6.719","volume":"53","author":"D Cousineau","year":"1983","unstructured":"Cousineau D, Rose CP, Lamoureux D, Goresky CA (1983) Changes in cardiac transcapillary exchange with metabolic coronary vasodilation in the intact dog. Circ Res 53:719\u2013730. doi: 10.1161\/01.RES.53.6.719","journal-title":"Circ Res"},{"key":"409_CR20","author":"F Crea","year":"2013","unstructured":"Crea F, Camici PG, Bairey Merz CN (2013) Coronary microvascular dysfunction: an update. Eur Heart J. doi: 10.1093\/eurheartj\/eht513","journal-title":"Eur Heart J"},{"key":"409_CR21","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF00788496","volume":"90","author":"E Czarnowska","year":"1995","unstructured":"Czarnowska E, Karwatowska-Prokopczuk E (1995) Ultrastructural demonstration of endothelial glycocalyx disruption in the reperfused rat heart. Involvement of oxygen free radicals. Basic Res Cardiol 90:357\u2013364. doi: 10.1007\/BF00788496","journal-title":"Basic Res Cardiol"},{"key":"409_CR22","first-page":"309","volume":"6","author":"DH Damon","year":"1987","unstructured":"Damon DH, Duling BR (1987) Are physiological changes in capillary tube hematocrit related to alterations in capillary perfusion heterogeneity? Int J Microcirc Clin Exp 6:309\u2013319","journal-title":"Int J Microcirc Clin Exp"},{"key":"409_CR23","doi-asserted-by":"crossref","unstructured":"Desjardins C, Duling BR (1990) Heparinase treatment suggests a role for the endothelial cell glycocalyx in regulation of capillary hematocrit. Am J Physiol 258:H647\u201354. http:\/\/ajpheart.physiology.org\/content\/258\/3\/H647.full-text.pdf","DOI":"10.1152\/ajpheart.1990.258.3.H647"},{"key":"409_CR24","doi-asserted-by":"crossref","unstructured":"Deussen A, Bassingthwaighte JB (1996) Modeling [15O]oxygen tracer data for estimating oxygen consumption. Am J Physiol 270:H1115\u201330. http:\/\/ajpheart.physiology.org\/content\/270\/3\/H1115.full-text.pdf","DOI":"10.1152\/ajpheart.1996.270.3.H1115"},{"key":"409_CR25","unstructured":"Diaz-Flores L, Gutierrez R, Madrid JF, Varela H, Valladares F, Acosta E, Martin-Vasallo P, Diaz-Flores L,Jr (2009) Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histol Histopathol 24:909\u2013969. http:\/\/hh.um.es\/pdf\/Vol_24\/24_7\/Diaz-Flores-24-909-969-2009.pdf"},{"key":"409_CR26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/01.RES.59.2.202","volume":"59","author":"WP Dole","year":"1986","unstructured":"Dole WP, Nuno DW (1986) Myocardial oxygen tension determines the degree and pressure range of coronary autoregulation. Circ Res 59:202\u2013215. doi: 10.1161\/01.RES.59.2.202","journal-title":"Circ Res"},{"key":"409_CR27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/01.RES.26.2.163","volume":"26","author":"BR Duling","year":"1970","unstructured":"Duling BR, Berne RM (1970) Propagated vasodilation in the microcirculation of the hamster cheek pouch. Circ Res 26:163\u2013170. doi: 10.1161\/01.RES.26.2.163","journal-title":"Circ Res"},{"key":"409_CR28","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1152\/physrev.00045.2006","volume":"88","author":"DJ Duncker","year":"2008","unstructured":"Duncker DJ, Bache RJ (2008) Regulation of coronary blood flow during exercise. Physiol Rev 88:1009\u20131086. doi: 10.1152\/physrev.00045.2006","journal-title":"Physiol Rev"},{"key":"409_CR29","doi-asserted-by":"crossref","unstructured":"Duran WN, Marsicano TH, Anderson RW (1977) Capillary reserve in isometrically contracting dog hearts. Am J Physiol 233:H276\u201381. http:\/\/ajpheart.physiology.org\/content\/233\/2\/H276.full-text.pdf","DOI":"10.1152\/ajpheart.1977.233.2.H276"},{"key":"409_CR30","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","volume":"364","author":"HK Eltzschig","year":"2011","unstructured":"Eltzschig HK, Carmeliet P (2011) Hypoxia and inflammation. N Engl J Med 364:656\u2013665. doi: 10.1056\/NEJMra0910283","journal-title":"N Engl J Med"},{"key":"409_CR31","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1086\/318809","volume":"68","author":"CM Eng","year":"2001","unstructured":"Eng CM, Banikazemi M, Gordon RE, Goldman M, Phelps R, Kim L, Gass A, Winston J, Dikman S, Fallon JT, Brodie S, Stacy CB, Mehta D, Parsons R, Norton K, O\u2019Callaghan M, Desnick RJ (2001) A phase 1\/2 clinical trial of enzyme replacement in fabry disease: pharmacokinetic, substrate clearance, and safety studies. Am J Hum Genet 68:711\u2013722. doi: 10.1086\/318809","journal-title":"Am J Hum Genet"},{"key":"409_CR32","doi-asserted-by":"crossref","unstructured":"Engler RL, Dahlgren MD, Peterson MA, Dobbs A, Schmid-Schonbein GW (1986) Accumulation of polymorphonuclear leukocytes during 3-h experimental myocardial ischemia. Am J Physiol 251:H93\u2013100. http:\/\/ajpheart.physiology.org\/content\/251\/1\/H93.full-text.pdf","DOI":"10.1152\/ajpheart.1986.251.1.H93"},{"key":"409_CR33","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/0002-9149(88)90148-8","volume":"61","author":"VJ Ferrans","year":"1988","unstructured":"Ferrans VJ, Milei J, Tomita Y, Storino RA (1988) Basement membrane thickening in cardiac myocytes and capillaries in chronic Chagas\u2019 disease. Am J Cardiol 61:1137\u20131140. doi: 10.1016\/0002-9149(88)90148-8","journal-title":"Am J Cardiol"},{"key":"409_CR34","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2337\/diab.28.8.713","volume":"28","author":"VW Fischer","year":"1979","unstructured":"Fischer VW, Barner HB, Leskiw ML (1979) Capillary basal laminar thickness in diabetic human myocardium. Diabetes 28:713\u2013719. doi: 10.2337\/diab.28.8.713","journal-title":"Diabetes"},{"key":"409_CR35","doi-asserted-by":"crossref","first-page":"H2450","DOI":"10.1152\/ajpheart.00790.2004","volume":"288","author":"DS Fokkema","year":"2005","unstructured":"Fokkema DS, VanTeeffelen JW, Dekker S, Vergroesen I, Reitsma JB, Spaan JA (2005) Diastolic time fraction as a determinant of subendocardial perfusion. Am J Physiol Heart Circ Physiol 288:H2450\u2013H2456. doi: 10.1152\/ajpheart.00790.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"409_CR36","doi-asserted-by":"crossref","unstructured":"Grattan MT, Hanley FL, Stevens MB, Hoffman JI (1986) Transmural coronary flow reserve patterns in dogs. Am J Physiol 250:H276\u201383. http:\/\/ajpheart.physiology.org\/content\/250\/2\/H276.full-text.pdf","DOI":"10.1152\/ajpheart.1986.250.2.H276"},{"key":"409_CR37","unstructured":"Haefliger IO, Anderson DR (1997) Oxygen modulation of guanylate cyclase-mediated retinal pericyte relaxations with 3-morpholino-sydnonimine and atrial natriuretic peptide. Invest Ophthalmol Vis Sci 38:1563\u20131568. http:\/\/iovs.org\/content\/38\/8\/1563.full.pdf"},{"key":"409_CR38","unstructured":"Haefliger IO, Zschauer A, Anderson DR (1994) Relaxation of retinal pericyte contractile tone through the nitric oxide-cyclic guanosine monophosphate pathway. Invest Ophthalmol Vis Sci 35:991\u2013997. http:\/\/iovs.org\/content\/35\/3\/991.full.pdf"},{"key":"409_CR39","author":"CN Hall","year":"2014","unstructured":"Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O\u2019Farrell FM, Buchan AM, Lauritzen M, Attwell D (2014) Capillary pericytes regulate cerebral blood flow in health and disease. Nature. doi: 10.1038\/nature13165","journal-title":"Nature"},{"key":"409_CR40","doi-asserted-by":"crossref","unstructured":"Hart BJ, Bian X, Gwirtz PA, Setty S, Downey HF (2001) Right ventricular oxygen supply\/demand balance in exercising dogs. Am J Physiol Heart Circ Physiol 281:H823\u201330. http:\/\/ajpheart.physiology.org\/content\/281\/2\/H823.full-text.pdf","DOI":"10.1152\/ajpheart.2001.281.2.H823"},{"key":"409_CR41","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1093\/cvr\/28.12.1737","volume":"28","author":"DJ Hearse","year":"1994","unstructured":"Hearse DJ (1994) Myocardial ischaemia: can we agree on a definition for the 21st century? Cardiovasc Res 28:1737\u20131744. doi: 10.1093\/cvr\/28.12.1737","journal-title":"Cardiovasc Res"},{"key":"409_CR42","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/BF01906411","volume":"71","author":"HW Heiss","year":"1976","unstructured":"Heiss HW, Barmeyer J, Wink K, Hell G, Cerny FJ, Keul J, Reindell H (1976) Studies on the regulation of myocardial blood flow in man. I.: training effects on blood flow and metabolism of the healthy heart at rest and during standardized heavy exercise. Basic Res Cardiol 71:658\u2013675. doi: 10.1007\/BF01906411","journal-title":"Basic Res Cardiol"},{"key":"409_CR43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00395-009-0074-7","volume":"105","author":"G Heusch","year":"2010","unstructured":"Heusch G (2010) Adenosine and maximum coronary vasodilation in humans: myth and misconceptions in the assessment of coronary reserve. Basic Res Cardiol 105:1\u20135. doi: 10.1007\/s00395-009-0074-7","journal-title":"Basic Res Cardiol"},{"key":"409_CR44","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1161\/CIRCULATIONAHA.109.888784","volume":"120","author":"G Heusch","year":"2009","unstructured":"Heusch G, Kleinbongard P, Bose D, Levkau B, Haude M, Schulz R, Erbel R (2009) Coronary microembolization: from bedside to bench and back to bedside. Circulation 120:1822\u20131836. doi: 10.1161\/CIRCULATIONAHA.109.888784","journal-title":"Circulation"},{"key":"409_CR45","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s00395-013-0380-y","volume":"108","author":"G Heusch","year":"2013","unstructured":"Heusch G, Kleinbongard P, Skyschally A (2013) Myocardial infarction and coronary microvascular obstruction: an intimate, but complicated relationship. Basic Res Cardiol 108:380. doi: 10.1007\/s00395-013-0380-y","journal-title":"Basic Res Cardiol"},{"key":"409_CR46","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.0954-6820.1971.tb07462.x","volume":"190","author":"S Holmberg","year":"1971","unstructured":"Holmberg S, Serzysko W, Varnauskas E (1971) Coronary circulation during heavy exercise in control subjects and patients with coronary heart disease. Acta Med Scand 190:465\u2013480. doi: 10.1111\/j.0954-6820.1971.tb07462.x","journal-title":"Acta Med Scand"},{"key":"409_CR47","doi-asserted-by":"crossref","unstructured":"Honig CR, Odoroff CL (1981) Calculated dispersion of capillary transit times: significance for oxygen exchange. Am J Physiol 240:H199\u2013208. http:\/\/ajpheart.physiology.org\/content\/240\/2\/H199.full-text.pdf","DOI":"10.1152\/ajpheart.1981.240.2.H199"},{"key":"409_CR48","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1016\/j.bpj.2009.02.047","volume":"96","author":"Y Huo","year":"2009","unstructured":"Huo Y, Kaimovitz B, Lanir Y, Wischgoll T, Hoffman JI, Kassab GS (2009) Biophysical model of the spatial heterogeneity of myocardial flow. Biophys J 96:4035\u20134043. doi: 10.1016\/j.bpj.2009.02.047","journal-title":"Biophys J"},{"key":"409_CR49","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1161\/CIRCULATIONAHA.107.738716","volume":"118","author":"R Iqbal","year":"2008","unstructured":"Iqbal R, Anand S, Ounpuu S, Islam S, Zhang X, Rangarajan S, Chifamba J, Al-Hinai A, Keltai M, Yusuf S, INTERHEART Study Investigators (2008) Dietary patterns and the risk of acute myocardial infarction in 52 countries: results of the INTERHEART study. Circulation 118:1929\u20131937. doi: 10.1161\/CIRCULATIONAHA.107.738716","journal-title":"Circulation"},{"key":"409_CR50","doi-asserted-by":"crossref","first-page":"H1199","DOI":"10.1152\/ajpheart.00945.2005","volume":"290","author":"BE Isakson","year":"2006","unstructured":"Isakson BE, Damon DN, Day KH, Liao Y, Duling BR (2006) Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulation. Am J Physiol Heart Circ Physiol 290:H1199\u2013H1205. doi: 10.1152\/ajpheart.00945.2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"409_CR51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4800(86)90027-4","volume":"44","author":"S Ishiharajima","year":"1986","unstructured":"Ishiharajima S, Aida T, Nakagawa R, Kameyama K, Sugano K, Oguro T, Asano G (1986) Early membrane damage during ischemia in rat heart. Exp Mol Pathol 44:1\u20136. doi: 10.1016\/0014-4800(86)90027-4","journal-title":"Exp Mol Pathol"},{"key":"409_CR52","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/jcbfm.2011.153","volume":"32","author":"SN Jespersen","year":"2012","unstructured":"Jespersen SN, \u00d8stergaard L (2012) The roles of cerebral blood flow, capillary transit time heterogeneity and oxygen tension in brain oxygenation and metabolism. J Cereb Blood Flow Metab 32:264\u2013277. doi: 10.1038\/jcbfm.2011.153","journal-title":"J Cereb Blood Flow Metab"},{"key":"409_CR53","first-page":"755","volume":"19","author":"H Kanatsuka","year":"1992","unstructured":"Kanatsuka H, Eastham CL, Marcus ML, Lamping KG (1992) Effects of nitroglycerin on the coronary microcirculation in normal and ischemic myocardium. J Cardiovasc Pharmacol 19:755\u2013763","journal-title":"J Cardiovasc Pharmacol"},{"key":"409_CR54","doi-asserted-by":"crossref","unstructured":"Kassab GS, Fung YC (1994) Topology and dimensions of pig coronary capillary network. Am J Physiol 267:H319\u201325. http:\/\/ajpheart.physiology.org\/content\/267\/1\/H319.full-text.pdf","DOI":"10.1152\/ajpheart.1994.267.1.H319"},{"key":"409_CR55","doi-asserted-by":"crossref","unstructured":"Kawamura H, Kobayashi M, Li Q, Yamanishi S, Katsumura K, Minami M, Wu DM, Puro DG (2004) Effects of angiotensin II on the pericyte-containing microvasculature of the rat retina. J Physiol 561:671\u2013683. http:\/\/ncbi.nlm.nih.gov\/pmc\/articles\/PMC1665385\/pdf\/tjp0561-0671.pdf","DOI":"10.1113\/jphysiol.2004.073098"},{"key":"409_CR56","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1113\/jphysiol.2003.047977","volume":"551","author":"H Kawamura","year":"2003","unstructured":"Kawamura H, Sugiyama T, Wu DM, Kobayashi M, Yamanishi S, Katsumura K, Puro DG (2003) ATP: a vasoactive signal in the pericyte-containing microvasculature of the rat retina. J Physiol 551:787\u2013799. doi: 10.1113\/jphysiol.2003.047977","journal-title":"J Physiol"},{"key":"409_CR57","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/01.RES.57.2.285","volume":"57","author":"RB King","year":"1985","unstructured":"King RB, Bassingthwaighte JB, Hales JR, Rowell LB (1985) Stability of heterogeneity of myocardial blood flow in normal awake baboons. Circ Res 57:285\u2013295. doi: 10.1161\/01.RES.57.2.285","journal-title":"Circ Res"},{"key":"409_CR58","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/BF02660885","volume":"24","author":"RB King","year":"1996","unstructured":"King RB, Raymond GM, Bassingthwaighte JB (1996) Modeling blood flow heterogeneity. Ann Biomed Eng 24:352\u2013372. doi: 10.1007\/BF02660885","journal-title":"Ann Biomed Eng"},{"key":"409_CR59","doi-asserted-by":"crossref","first-page":"H1437","DOI":"10.1152\/ajpheart.00088.2004","volume":"288","author":"T Kiyooka","year":"2005","unstructured":"Kiyooka T, Hiramatsu O, Shigeto F, Nakamoto H, Tachibana H, Yada T, Ogasawara Y, Kajiya M, Morimoto T, Morizane Y, Mohri S, Shimizu J, Ohe T, Kajiya F (2005) Direct observation of epicardial coronary capillary hemodynamics during reactive hyperemia and during adenosine administration by intravital video microscopy. Am J Physiol Heart Circ Physiol 288:H1437\u2013H1443. doi: 10.1152\/ajpheart.00088.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"409_CR60","doi-asserted-by":"crossref","unstructured":"Klitzman B, Duling BR (1979) Microvascular hematocrit and red cell flow in resting and contracting striated muscle. Am J Physiol 237:H481\u201390. http:\/\/ajpheart.physiology.org\/content\/237\/4\/H481.full-text.pdf","DOI":"10.1152\/ajpheart.1979.237.4.H481"},{"key":"409_CR61","volume-title":"Nobel Lecture: a contribution to the physiology of the capillaries","author":"A Krogh","year":"1967","unstructured":"Krogh A (1967) Nobel Lecture: a contribution to the physiology of the capillaries. Elsevier Publishing Company, Amsterdam"},{"key":"409_CR62","doi-asserted-by":"crossref","unstructured":"Krogh A (1919) The supply of oxygen to the tissues and the regulation of the capillary circulation. J Physiol (London) 52:457\u2013474. http:\/\/ncbi.nlm.nih.gov\/pmc\/articles\/PMC1402718\/pdf\/jphysiol01760-0067.pdf","DOI":"10.1113\/jphysiol.1919.sp001844"},{"key":"409_CR63","doi-asserted-by":"crossref","unstructured":"Kroll K, Wilke N, Jerosch-Herold M, Wang Y, Zhang Y, Bache RJ, Bassingthwaighte JB (1996) Modeling regional myocardial flows from residue functions of an intravascular indicator. Am J Physiol 271:H1643\u201355. http:\/\/ajpheart.physiology.org\/content\/271\/4\/H1643.full-text.pdf","DOI":"10.1152\/ajpheart.1996.271.4.H1643"},{"key":"409_CR64","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1161\/CIRCULATIONAHA.109.900191","volume":"121","author":"GA Lanza","year":"2010","unstructured":"Lanza GA, Crea F (2010) Primary coronary microvascular dysfunction: clinical presentation, pathophysiology, and management. Circulation 121:2317\u20132325. doi: 10.1161\/CIRCULATIONAHA.109.900191","journal-title":"Circulation"},{"key":"409_CR65","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/BF02684839","volume":"25","author":"Z Li","year":"1997","unstructured":"Li Z, Yipintsoi T, Bassingthwaighte JB (1997) Nonlinear model for capillary-tissue oxygen transport and metabolism. Ann Biomed Eng 25:604\u2013619. doi: 10.1007\/BF02684839","journal-title":"Ann Biomed Eng"},{"key":"409_CR66","author":"S Lidder","year":"2012","unstructured":"Lidder S, Webb AJ (2012) Vascular effects of dietary nitrate (as found in green leafy vegetables & beetroot) via the nitrate-nitrite-nitric oxide pathway. Br J Clin Pharmacol. doi: 10.1111\/j.1365-2125.2012.04420.x","journal-title":"Br J Clin Pharmacol"},{"key":"409_CR67","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1523-5378.2007.00511.x","volume":"12","author":"A Manolakis","year":"2007","unstructured":"Manolakis A, Kapsoritakis AN, Potamianos SP (2007) A review of the postulated mechanisms concerning the association of Helicobacter pylori with ischemic heart disease. Helicobacter 12:287\u2013297. doi: 10.1111\/j.1523-5378.2007.00511.x","journal-title":"Helicobacter"},{"key":"409_CR68","unstructured":"Matsugi T, Chen Q, Anderson DR (1997) Adenosine-induced relaxation of cultured bovine retinal pericytes. Invest Ophthalmol Vis Sci 38:2695\u20132701. http:\/\/iovs.org\/content\/38\/13\/2695.full.pdf"},{"key":"409_CR69","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0008-6363(96)00146-0","volume":"32","author":"MC Mazzoni","year":"1996","unstructured":"Mazzoni MC, Schmid-Schonbein GW (1996) Mechanisms and consequences of cell activation in the microcirculation. Cardiovasc Res 32:709\u2013719. doi: 10.1016\/0008-6363(96)00146-0","journal-title":"Cardiovasc Res"},{"key":"409_CR70","first-page":"530","volume":"24","author":"JG Meeder","year":"1997","unstructured":"Meeder JG, Blanksma PK, van der Wall EE, Willemsen AT, Pruim J, Anthonio RL, de Jong RM, Vaalburg W, Lie KI (1997) Coronary vasomotion in patients with syndrome X: evaluation with positron emission tomography and parametric myocardial perfusion imaging. Eur J Nucl Med 24:530\u2013537. doi: 10.1007\/BF01267685","journal-title":"Eur J Nucl Med"},{"key":"409_CR71","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1172\/JCI104531","volume":"41","author":"JV Messer","year":"1962","unstructured":"Messer JV, Wagman RJ, Levine HJ, Neill WA, Krasnow N, Gorlin R (1962) Patterns of human myocardial oxygen extraction during rest and exercise. J Clin Invest 41:725\u2013742. doi: 10.1172\/JCI104531","journal-title":"J Clin Invest"},{"key":"409_CR72","doi-asserted-by":"crossref","first-page":"94A","DOI":"10.1016\/S0002-9149(97)00463-3","volume":"80","author":"C Meyer","year":"1997","unstructured":"Meyer C, Schwaiger M (1997) Myocardial blood flow and glucose metabolism in diabetes mellitus. Am J Cardiol 80:94A\u2013101A. doi: 10.1016\/S0002-9149(97)00463-3","journal-title":"Am J Cardiol"},{"key":"409_CR73","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.jacc.2012.05.052","volume":"60","author":"G Morton","year":"2012","unstructured":"Morton G, Chiribiri A, Ishida M, Hussain ST, Schuster A, Indermuehle A, Perera D, Knuuti J, Baker S, Hedstrom E, Schleyer P, O\u2019Doherty M, Barrington S, Nagel E (2012) Quantification of absolute myocardial perfusion in patients with coronary artery disease: comparison between cardiovascular magnetic resonance and positron emission tomography. J Am Coll Cardiol 60:1546\u20131555. doi: 10.1016\/j.jacc.2012.05.052","journal-title":"J Am Coll Cardiol"},{"key":"409_CR74","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.CIR.84.1.203","volume":"84","author":"M Mosseri","year":"1991","unstructured":"Mosseri M, Schaper J, Admon D, Hasin Y, Gotsman MS, Sapoznikov D, Pickering JG, Yarom R (1991) Coronary capillaries in patients with congestive cardiomyopathy or angina pectoris with patent main coronary arteries. Ultrastructural morphometry of endomyocardial biopsy samples. Circulation 84:203\u2013210. doi: 10.1161\/01.CIR.84.1.203","journal-title":"Circulation"},{"key":"409_CR75","unstructured":"Mouridsen K, \u00d8stergaard L, Christensen S, Jespersen SN (2011) Reliable Estimation of Capillary Transit Time Distributions at Voxel-Level using DSC-MRI. In: Proceedings of the International Society for Magnetic Resonance in Medicines 19th Annual Meeting and Exhibition: 3915. http:\/\/cds.ismrm.org\/protected\/11MProceedings\/files\/3915.pdf"},{"key":"409_CR76","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/cvr\/cvp271","volume":"85","author":"J Musiolik","year":"2010","unstructured":"Musiolik J, van Caster P, Skyschally A, Boengler K, Gres P, Schulz R, Heusch G (2010) Reduction of infarct size by gentle reperfusion without activation of reperfusion injury salvage kinases in pigs. Cardiovasc Res 85:110\u2013117. doi: 10.1093\/cvr\/cvp271","journal-title":"Cardiovasc Res"},{"key":"409_CR77","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2337\/diabetes.55.04.06.db05-1619","volume":"55","author":"M Nieuwdorp","year":"2006","unstructured":"Nieuwdorp M, Mooij HL, Kroon J, Atasever B, Spaan JA, Ince C, Holleman F, Diamant M, Heine RJ, Hoekstra JB, Kastelein JJ, Stroes ES, Vink H (2006) Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes. Diabetes 55:1127\u20131132. doi: 10.2337\/diabetes.55.04.06.db05-1619","journal-title":"Diabetes"},{"key":"409_CR78","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/00004647-199906000-00013","volume":"19","author":"L \u00d8stergaard","year":"1999","unstructured":"\u00d8stergaard L, Chesler DA, Weisskoff RM, Sorensen AG, Rosen BR (1999) Modeling cerebral blood flow and flow heterogeneity from magnetic resonance residue data. J Cereb Blood Flow Metab 19:690\u2013699. doi: 10.1097\/00004647-199906000-00013","journal-title":"J Cereb Blood Flow Metab"},{"key":"409_CR79","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/jcbfm.2013.18","volume":"33","author":"L \u00d8stergaard","year":"2013","unstructured":"\u00d8stergaard L, Jespersen SN, Mouridsen K, Mikkelsen IK, Jonsdottir KY, Tietze A, Blicher JU, Aamand R, Hjort N, Iversen NK, Cai C, Dupont K, Simonsen CZ, Weitzel-Mudersbach PV, Modrau B, Nagenthiraja K, Ribe LR, Hansen MB, Bekke SL, Dahlman MG, Puig J, Pedraza S, Serena J, Cho TH, Siemonsen S, Thomalla G, Fiehler J, Nighoghossian N, Andersen G (2013) The Role of the Cerebral Capillaries in Acute Ischemic Stroke: The extended Penumbra Model. J Cereb Blood Flow Metab 33:635\u2013648. doi: 10.1038\/jcbfm.2013.18","journal-title":"J Cereb Blood Flow Metab"},{"key":"409_CR80","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1158\/0008-5472.CAN-13-0964","volume":"73","author":"L \u00d8stergaard","year":"2013","unstructured":"\u00d8stergaard L, Tietze A, Nielsen T, Drasbek KR, Mouridsen K, Jespersen SN, Horsman MR (2013) The Relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis. Cancer Res 73:5618\u20135624. doi: 10.1158\/0008-5472.CAN-13-0964","journal-title":"Cancer Res"},{"key":"409_CR81","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0002-8703(89)90723-0","volume":"117","author":"CF Peng","year":"1989","unstructured":"Peng CF, Murphy ML, Colwell K, Straub KD (1989) Controlled versus hyperemic flow during reperfusion of jeopardized ischemic myocardium. Am Heart J 117:515\u2013522. doi: 10.1016\/0002-8703(89)90723-0","journal-title":"Am Heart J"},{"key":"409_CR82","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.RES.47.6.911","volume":"47","author":"S Penpargkul","year":"1980","unstructured":"Penpargkul S, Schaible T, Yipintsoi T, Scheuer J (1980) The effect of diabetes on performance and metabolism of rat hearts. Circ Res 47:911\u2013921. doi: 10.1161\/01.RES.47.6.911","journal-title":"Circ Res"},{"key":"409_CR83","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/cvr\/cvn136","volume":"80","author":"AR Pries","year":"2008","unstructured":"Pries AR, Habazettl H, Ambrosio G, Hansen PR, Kaski JC, Schachinger V, Tillmanns H, Vassalli G, Tritto I, Weis M, de Wit C, Bugiardini R (2008) A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings. Cardiovasc Res 80:165\u2013174. doi: 10.1093\/cvr\/cvn136","journal-title":"Cardiovasc Res"},{"key":"409_CR84","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/cvr\/cvn318","volume":"81","author":"AR Pries","year":"2009","unstructured":"Pries AR, Secomb TW (2009) Origins of heterogeneity in tissue perfusion and metabolism. Cardiovasc Res 81:328\u2013335. doi: 10.1093\/cvr\/cvn318","journal-title":"Cardiovasc Res"},{"key":"409_CR85","doi-asserted-by":"crossref","unstructured":"Pries AR, Secomb TW, Gaehtgens P (1996) Relationship between structural and hemodynamic heterogeneity in microvascular networks. Am J Physiol 270:H545\u201353. http:\/\/ajpheart.physiology.org\/content\/270\/2\/H545.full-text.pdf","DOI":"10.1152\/ajpheart.1996.270.2.H545"},{"key":"409_CR86","doi-asserted-by":"crossref","unstructured":"Pries AR, Secomb TW, Gaehtgens P (1995) Structure and hemodynamics of microvascular networks: heterogeneity and correlations. Am J Physiol 269:H1713\u201322. http:\/\/ajpheart.physiology.org\/content\/269\/5\/H1713.full-text.pdf","DOI":"10.1152\/ajpheart.1995.269.5.H1713"},{"key":"409_CR87","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1161\/ATVBAHA.112.252783","volume":"32","author":"G Rath","year":"2012","unstructured":"Rath G, Saliez J, Behets G, Romero-Perez M, Leon-Gomez E, Bouzin C, Vriens J, Nilius B, Feron O, Dessy C (2012) Vascular hypoxic preconditioning relies on TRPV4-dependent calcium influx and proper intercellular gap junctions communication. Arterioscler Thromb Vasc Biol 32:2241\u20132249. doi: 10.1161\/ATVBAHA.112.252783","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"409_CR88","doi-asserted-by":"crossref","unstructured":"Renkin EM (1985) B. W. Zweifach Award lecture. Regulation of the microcirculation. Microvasc Res 30:251\u2013263","DOI":"10.1016\/0026-2862(85)90057-3"},{"key":"409_CR89","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/01.RES.39.4.541","volume":"39","author":"CP Rose","year":"1976","unstructured":"Rose CP, Goresky CA (1976) Vasomotor control of capillary transit time heterogeneity in the canine coronary circulation. Circ Res 39:541\u2013554. doi: 10.1161\/01.RES.39.4.541","journal-title":"Circ Res"},{"key":"409_CR90","first-page":"916","volume":"88","author":"CMB Rouget","year":"1879","unstructured":"Rouget CMB (1879) Sur la contractilit\u00e9 capillaires sanguins. Compt Rend Acad Sci Paris 88:916\u2013918","journal-title":"Compt Rend Acad Sci Paris"},{"key":"409_CR91","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1006\/mvre.1998.2086","volume":"56","author":"U Schonfelder","year":"1998","unstructured":"Schonfelder U, Hofer A, Paul M, Funk RH (1998) In situ observation of living pericytes in rat retinal capillaries. Microvasc Res 56:22\u201329. doi: 10.1006\/mvre.1998.2086","journal-title":"Microvasc Res"},{"key":"409_CR92","doi-asserted-by":"crossref","unstructured":"Schwanke U, Deussen A, Heusch G, Schipke JD (2000) Heterogeneity of local myocardial flow and oxidative metabolism. Am J Physiol Heart Circ Physiol 279:H1029\u201335. http:\/\/ajpheart.physiology.org\/content\/279\/3\/H1029.full-text.pdf","DOI":"10.1152\/ajpheart.2000.279.3.H1029"},{"key":"409_CR93","first-page":"H1016","volume":"274","author":"TW Secomb","year":"1998","unstructured":"Secomb TW, Hsu R, Pries AR (1998) A model for red blood cell motion in glycocalyx-lined capillaries. Am J Physiol 274:H1016\u2013H1022","journal-title":"Am J Physiol"},{"key":"409_CR94","doi-asserted-by":"crossref","unstructured":"Segal SS, Duling BR (1989) Conduction of vasomotor responses in arterioles: a role for cell-to-cell coupling?. Am J Physiol 256:H838\u201345. http:\/\/ajpheart.physiology.org\/content\/256\/3\/H838.full-text.pdf","DOI":"10.1152\/ajpheart.1989.256.3.H838"},{"key":"409_CR95","doi-asserted-by":"crossref","unstructured":"Segal SS, Duling BR (1986) Flow control among microvessels coordinated by intercellular conduction. Science 234:868\u2013870. http:\/\/jstor.org\/stable\/1698093","DOI":"10.1126\/science.3775368"},{"key":"409_CR96","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0735-1097(99)00137-0","volume":"33","author":"T Sheth","year":"1999","unstructured":"Sheth T, Nair C, Muller J, Yusuf S (1999) Increased winter mortality from acute myocardial infarction and stroke: the effect of age. J Am Coll Cardiol 33:1916\u20131919. doi: 10.1016\/S0735-1097(99)00137-0","journal-title":"J Am Coll Cardiol"},{"key":"409_CR97","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/CIRCULATIONAHA.105.558122","volume":"112","author":"P Staat","year":"2005","unstructured":"Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L\u2019Huillier I, Aupetit JF, Bonnefoy E, Finet G, Andre-Fouet X, Ovize M (2005) Postconditioning the human heart. Circulation 112:2143\u20132148. doi: 10.1161\/CIRCULATIONAHA.105.558122","journal-title":"Circulation"},{"key":"409_CR98","doi-asserted-by":"crossref","unstructured":"Stewart GN (1893) Researches on the circulation time in organs and on the influences which affect it. Parts I\u2013III. J Physiol 15:1\u201389. http:\/\/jp.physoc.org\/content\/15\/1-2\/1.full.pdf","DOI":"10.1113\/jphysiol.1893.sp000462"},{"key":"409_CR99","doi-asserted-by":"crossref","first-page":"34G","DOI":"10.1016\/0002-9149(90)90957-3","volume":"65","author":"BE Strauer","year":"1990","unstructured":"Strauer BE (1990) Significance of coronary circulation in hypertensive heart disease for development and prevention of heart failure. Am J Cardiol 65:34G\u201341G. doi: 10.1016\/0002-9149(90)90957-3","journal-title":"Am J Cardiol"},{"key":"409_CR100","doi-asserted-by":"crossref","unstructured":"Takemura G, Takatsu Y, Fujiwara H (1998) Luminal narrowing of coronary capillaries in human hypertrophic hearts: an ultrastructural morphometrical study using endomyocardial biopsy specimens. Heart 79:78\u201385. http:\/\/heart.bmj.com\/content\/79\/1\/78.full.pdf","DOI":"10.1136\/hrt.79.1.78"},{"key":"409_CR101","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s003950050114","volume":"93","author":"CP Tiefenbacher","year":"1998","unstructured":"Tiefenbacher CP, Chilian WM (1998) Heterogeneity of coronary vasomotion. Basic Res Cardiol 93:446\u2013454. doi: 10.1007\/s003950050114","journal-title":"Basic Res Cardiol"},{"key":"409_CR102","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0026-2862(79)90041-4","volume":"18","author":"RG Tilton","year":"1979","unstructured":"Tilton RG, Kilo C, Williamson JR (1979) Pericyte-endothelial relationships in cardiac and skeletal muscle capillaries. Microvasc Res 18:325\u2013335. doi: 10.1016\/0026-2862(79)90041-4","journal-title":"Microvasc Res"},{"key":"409_CR103","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0026-2862(79)90042-6","volume":"18","author":"RG Tilton","year":"1979","unstructured":"Tilton RG, Kilo C, Williamson JR, Murch DW (1979) Differences in pericyte contractile function in rat cardiac and skeletal muscle microvasculatures. Microvasc Res 18:336\u2013352. doi: 10.1016\/0026-2862(79)90042-6","journal-title":"Microvasc Res"},{"key":"409_CR104","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00418-004-0696-7","volume":"122","author":"RM Touyz","year":"2004","unstructured":"Touyz RM, Schiffrin EL (2004) Reactive oxygen species in vascular biology: implications in hypertension. Histochem Cell Biol 122:339\u2013352. doi: 10.1007\/s00418-004-0696-7","journal-title":"Histochem Cell Biol"},{"key":"409_CR105","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1161\/01.RES.0000065917.53950.75","volume":"92","author":"BM Berg van den","year":"2003","unstructured":"van den Berg BM, Vink H, Spaan JA (2003) The endothelial glycocalyx protects against myocardial edema. Circ Res 92:592\u2013594. doi: 10.1161\/01.RES.0000065917.53950.75","journal-title":"Circ Res"},{"key":"409_CR106","doi-asserted-by":"crossref","first-page":"H2848","DOI":"10.1152\/ajpheart.00117.2003","volume":"285","author":"PM Haaren van","year":"2003","unstructured":"van Haaren PM, VanBavel E, Vink H, Spaan JA (2003) Localization of the permeability barrier to solutes in isolated arteries by confocal microscopy. Am J Physiol Heart Circ Physiol 285:H2848\u2013H2856. doi: 10.1152\/ajpheart.00117.2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"409_CR107","doi-asserted-by":"crossref","first-page":"H496","DOI":"10.1152\/ajpheart.00584.2013","volume":"306","author":"P Horssen van","year":"2014","unstructured":"van Horssen P, van den Wijngaard JP, Brandt MJ, Hoefer IE, Spaan JA, Siebes M (2014) Perfusion territories subtended by penetrating coronary arteries increase in size and decrease in number toward the subendocardium. Am J Physiol Heart Circ Physiol 306:H496\u2013H504. doi: 10.1152\/ajpheart.00584.2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"409_CR108","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/HYPERTENSIONAHA.107.089250","volume":"50","author":"JW VanTeeffelen","year":"2007","unstructured":"VanTeeffelen JW, Brands J, Jansen C, Spaan JA, Vink H (2007) Heparin impairs glycocalyx barrier properties and attenuates shear dependent vasodilation in mice. Hypertension 50:261\u2013267. doi: 10.1161\/HYPERTENSIONAHA.107.089250","journal-title":"Hypertension"},{"key":"409_CR109","doi-asserted-by":"crossref","first-page":"H2508","DOI":"10.1152\/ajpheart.00446.2005","volume":"289","author":"JW VanTeeffelen","year":"2005","unstructured":"VanTeeffelen JW, Dekker S, Fokkema DS, Siebes M, Vink H, Spaan JA (2005) Hyaluronidase treatment of coronary glycocalyx increases reactive hyperemia but not adenosine hyperemia in dog hearts. Am J Physiol Heart Circ Physiol 289:H2508\u2013H2513. doi: 10.1152\/ajpheart.00446.2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"409_CR110","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1161\/01.CIR.101.13.1500","volume":"101","author":"H Vink","year":"2000","unstructured":"Vink H, Constantinescu AA, Spaan JA (2000) Oxidized lipoproteins degrade the endothelial surface layer: implications for platelet-endothelial cell adhesion. Circulation 101:1500\u20131502. doi: 10.1161\/01.CIR.101.13.1500","journal-title":"Circulation"},{"key":"409_CR111","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/01.RES.79.3.581","volume":"79","author":"H Vink","year":"1996","unstructured":"Vink H, Duling BR (1996) Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillaries. Circ Res 79:581\u2013589. doi: 10.1161\/01.RES.79.3.581","journal-title":"Circ Res"},{"key":"409_CR112","doi-asserted-by":"crossref","unstructured":"Vink H, Wieringa PA, Spaan JA (1995) Evidence that cell surface charge reduction modifies capillary red cell velocity-flux relationships in hamster cremaster muscle. J Physiol 489 (Pt 1):193\u2013201. http:\/\/ncbi.nlm.nih.gov\/pmc\/articles\/PMC1156803\/pdf\/jphysiol00304-0191.pdf","DOI":"10.1113\/jphysiol.1995.sp021041"},{"key":"409_CR113","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jacc.2004.11.044","volume":"45","author":"R Vogel","year":"2005","unstructured":"Vogel R, Indermuhle A, Reinhardt J, Meier P, Siegrist PT, Namdar M, Kaufmann PA, Seiler C (2005) The quantification of absolute myocardial perfusion in humans by contrast echocardiography: algorithm and validation. J Am Coll Cardiol 45:754\u2013762. doi: 10.1016\/j.jacc.2004.11.044","journal-title":"J Am Coll Cardiol"},{"key":"409_CR114","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.RES.42.1.119","volume":"42","author":"HR Weiss","year":"1978","unstructured":"Weiss HR, Sinha AK (1978) Regional oxygen saturation of small arteries and veins in the canine myocardium. Circ Res 42:119\u2013126","journal-title":"Circ Res"},{"key":"409_CR115","first-page":"137","volume":"13","author":"PA Wieringa","year":"1993","unstructured":"Wieringa PA, Stassen HG, Van Kan JJ, Spaan JA (1993) Oxygen diffusion in a network model of the myocardial microcirculation. Int J Microcirc Clin Exp 13:137\u2013169","journal-title":"Int J Microcirc Clin Exp"},{"key":"409_CR116","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0140-6736(94)92689-1","volume":"343","author":"PR Woodhouse","year":"1994","unstructured":"Woodhouse PR, Khaw KT, Plummer M, Foley A, Meade TW (1994) Seasonal variations of plasma fibrinogen and factor VII activity in the elderly: winter infections and death from cardiovascular disease. Lancet 343:435\u2013439. doi: 10.1016\/S0140-6736(94)92689-1","journal-title":"Lancet"},{"key":"409_CR117","doi-asserted-by":"crossref","first-page":"H2083","DOI":"10.1152\/ajpheart.01007.2002","volume":"284","author":"DM Wu","year":"2003","unstructured":"Wu DM, Kawamura H, Sakagami K, Kobayashi M, Puro DG (2003) Cholinergic regulation of pericyte-containing retinal microvessels. Am J Physiol Heart Circ Physiol 284:H2083\u2013H2090. doi: 10.1152\/ajpheart.01007.2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"409_CR118","doi-asserted-by":"crossref","first-page":"H925","DOI":"10.1152\/ajpheart.01012.2005","volume":"290","author":"S Yamanishi","year":"2006","unstructured":"Yamanishi S, Katsumura K, Kobayashi T, Puro DG (2006) Extracellular lactate as a dynamic vasoactive signal in the rat retinal microvasculature. Am J Physiol Heart Circ Physiol 290:H925\u2013H934. doi: 10.1152\/ajpheart.01012.2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"409_CR119","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","volume":"357","author":"DM Yellon","year":"2007","unstructured":"Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357:1121\u20131135. doi: 10.1056\/NEJMra071667","journal-title":"N Engl J Med"},{"key":"409_CR120","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/nm.2022","volume":"15","author":"M Yemisci","year":"2009","unstructured":"Yemisci M, Gursoy-Ozdemir Y, Vural A, Can A, Topalkara K, Dalkara T (2009) Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med 15:1031\u20131037. doi: 10.1038\/nm.2022","journal-title":"Nat Med"},{"key":"409_CR121","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1161\/01.RES.33.5.573","volume":"33","author":"T Yipintsoi","year":"1973","unstructured":"Yipintsoi T, Dobbs WA Jr, Scanlon PD, Knopp TJ, Bassingthwaighte JB (1973) Regional distribution of diffusible tracers and carbonized microspheres in the left ventricle of isolated dog hearts. Circ Res 33:573\u2013587. doi: 10.1161\/01.RES.33.5.573","journal-title":"Circ Res"},{"key":"409_CR122","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0165-5728(97)00151-3","volume":"80","author":"T Yong","year":"1997","unstructured":"Yong T, Zheng MQ, Linthicum DS (1997) Nicotine induces leukocyte rolling and adhesion in the cerebral microcirculation of the mouse. J Neuroimmunol 80:158\u2013164. doi: 10.1016\/S0165-5728(97)00151-3","journal-title":"J Neuroimmunol"},{"key":"409_CR123","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1002\/jcp.22640","volume":"226","author":"G Yuan","year":"2011","unstructured":"Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR (2011) Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J Cell Physiol 226:2925\u20132933. doi: 10.1002\/jcp.22640","journal-title":"J Cell Physiol"},{"key":"409_CR124","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0008-6363(99)00231-X","volume":"44","author":"CJ Zuurbier","year":"1999","unstructured":"Zuurbier CJ, van Iterson M, Ince C (1999) Functional heterogeneity of oxygen supply-consumption ratio in the heart. Cardiovasc Res 44:488\u2013497. doi: 10.1016\/S0008-6363(99)00231-X","journal-title":"Cardiovasc Res"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00395-014-0409-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-014-0409-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-014-0409-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T12:58:42Z","timestamp":1565355522000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00395-014-0409-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,18]]},"references-count":124,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["409"],"URL":"https:\/\/doi.org\/10.1007\/s00395-014-0409-x","relation":{},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,18]]},"article-number":"409"}}