{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:43:35Z","timestamp":1793054615847,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s00395-016-0569-y","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T14:51:01Z","timestamp":1468421461000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution"],"prefix":"10.1007","volume":"111","author":[{"given":"Sabine","family":"Ameling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gourav","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Beug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Steil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Reinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Weitmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Grube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Trimpert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Kandolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Nauck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"D\u00f6rr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Empen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan B.","family":"Felix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"V\u00f6lker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,13]]},"reference":[{"key":"569_CR1","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1093\/eurheartj\/ehs330","volume":"34","author":"S Ameling","year":"2013","unstructured":"Ameling S, Herda LR, Hammer E, Steil L, Teumer A, Trimpert C, Dorr M, Kroemer HK, Klingel K, Kandolf R, Volker U, Felix SB (2013) Myocardial gene expression profiles and cardiodepressant autoantibodies predict response of patients with dilated cardiomyopathy to immunoadsorption therapy. Eur Heart J 34:666\u2013675. doi:10.1093\/eurheartj\/ehs330","journal-title":"Eur Heart J"},{"key":"569_CR2","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0046-8177(87)80363-5","volume":"18","author":"HT Aretz","year":"1987","unstructured":"Aretz HT (1987) Myocarditis: the Dallas criteria. Hum Pathol 18:619\u2013624. doi:10.1016\/S0046-8177(87)80363-5","journal-title":"Hum Pathol"},{"key":"569_CR3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3109\/1354750X.2012.677860","volume":"17","author":"Y Bai","year":"2012","unstructured":"Bai Y, Zhang P, Zhang X, Huang J, Hu S, Wei Y (2012) LTBP-2 acts as a novel marker in human heart failure\u2014a preliminary study. Biomarkers 17:407\u2013415. doi:10.3109\/1354750X.2012.677860","journal-title":"Biomarkers"},{"key":"569_CR4","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s12265-011-9339-2","volume":"5","author":"AS Barth","year":"2012","unstructured":"Barth AS, Chakir K, Kass DA, Tomaselli GF (2012) Transcriptome, proteome, and metabolome in dyssynchronous heart failure and CRT. J Cardiovasc Transl Res 5:180\u2013187. doi:10.1007\/s12265-011-9339-2","journal-title":"J Cardiovasc Transl Res"},{"key":"569_CR5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.febslet.2004.07.055","volume":"573","author":"R Breitling","year":"2004","unstructured":"Breitling R, Armengaud P, Amtmann A, Herzyk P (2004) Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett 573:83\u201392. doi:10.1016\/j.febslet.2004.07.055","journal-title":"FEBS Lett"},{"key":"569_CR6","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/sji.12000","volume":"77","author":"D Bulut","year":"2013","unstructured":"Bulut D, Creutzenberg G, Mugge A (2013) The number of regulatory T cells correlates with hemodynamic improvement in patients with inflammatory dilated cardiomyopathy after immunoadsorption therapy. Scand J Immunol 77:54\u201361. doi:10.1111\/sji.12000","journal-title":"Scand J Immunol"},{"key":"569_CR7","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00392-011-0287-2","volume":"100","author":"D Bulut","year":"2011","unstructured":"Bulut D, Scheeler M, Niedballa LM, Miebach T, Mugge A (2011) Effects of immunoadsorption on endothelial function, circulating endothelial progenitor cells and circulating microparticles in patients with inflammatory dilated cardiomyopathy. Clin Res Cardiol 100:603\u2013610. doi:10.1007\/s00392-011-0287-2","journal-title":"Clin Res Cardiol"},{"key":"569_CR8","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1161\/CIRCULATIONAHA.106.641472","volume":"115","author":"AL Caforio","year":"2007","unstructured":"Caforio AL, Mahon NG, Baig MK, Tona F, Murphy RT, Elliott PM, McKenna WJ (2007) Prospective familial assessment in dilated cardiomyopathy: cardiac autoantibodies predict disease development in asymptomatic relatives. Circulation 115:76\u201383. doi:10.1161\/CIRCULATIONAHA.106.641472","journal-title":"Circulation"},{"key":"569_CR9","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1093\/eurheartj\/eht210","volume":"34","author":"AL Caforio","year":"2013","unstructured":"Caforio AL, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, Fu M, Helio T, Heymans S, Jahns R, Klingel K, Linhart A, Maisch B, McKenna W, Mogensen J, Pinto YM, Ristic A, Schultheiss HP, Seggewiss H, Tavazzi L, Thiene G, Yilmaz A, Charron P, Elliott PM (2013) Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 34:2636\u20132648. doi:10.1093\/eurheartj\/eht210","journal-title":"Eur Heart J"},{"key":"569_CR10","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1006\/jmcc.2000.1215","volume":"32","author":"MM Chen","year":"2000","unstructured":"Chen MM, Lam A, Abraham JA, Schreiner GF, Joly AH (2000) CTGF expression is induced by TGF-beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis. J Mol Cell Cardiol 32:1805\u20131819. doi:10.1006\/jmcc.2000.1215","journal-title":"J Mol Cell Cardiol"},{"key":"569_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0065-2776(08)00604-4","volume":"99","author":"D Cihakova","year":"2008","unstructured":"Cihakova D, Rose NR (2008) Pathogenesis of myocarditis and dilated cardiomyopathy. Adv Immunol 99:95\u2013114. doi:10.1016\/S0065-2776(08)00604-4","journal-title":"Adv Immunol"},{"key":"569_CR12","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1161\/CIRCULATIONAHA.107.186093","volume":"116","author":"LT Cooper","year":"2007","unstructured":"Cooper LT, Baughman KL, Feldman AM, Frustaci A, Jessup M, Kuhl U, Levine GN, Narula J, Starling RC, Towbin J, Virmani R (2007) The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Circulation 116:2216\u20132233. doi:10.1161\/CIRCULATIONAHA.107.186093","journal-title":"Circulation"},{"key":"569_CR13","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.ejheart.2008.08.005","volume":"10","author":"K Dickstein","year":"2008","unstructured":"Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Stromberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K (2008) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 10:933\u2013989. doi:10.1016\/j.ejheart.2008.08.005","journal-title":"Eur J Heart Fail"},{"key":"569_CR14","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.cca.2011.10.032","volume":"413","author":"N Dong","year":"2012","unstructured":"Dong N, Chen S, Wang W, Zhou Y, Wu Q (2012) Corin in clinical laboratory diagnostics. Clin Chim Acta 413:378\u2013383. doi:10.1016\/j.cca.2011.10.032","journal-title":"Clin Chim Acta"},{"key":"569_CR15","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1111\/febs.12235","volume":"280","author":"KV Engebretsen","year":"2013","unstructured":"Engebretsen KV, Lunde IG, Strand ME, Waehre A, Sjaastad I, Marstein HS, Skrbic B, Dahl CP, Askevold ET, Christensen G, Bjornstad JL, Tonnessen T (2013) Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli. FEBS J 280:2382\u20132398. doi:10.1111\/febs.12235","journal-title":"FEBS J"},{"key":"569_CR16","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1016\/S0735-1097(00)00568-4","volume":"35","author":"SB Felix","year":"2000","unstructured":"Felix SB, Staudt A, Dorffel WV, Stangl V, Merkel K, Pohl M, Docke WD, Morgera S, Neumayer HH, Wernecke KD, Wallukat G, Stangl K, Baumann G (2000) Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy: three-month results from a randomized study. J Am Coll Cardiol 35:1590\u20131598. doi:10.1016\/S0735-1097(00)00568-4","journal-title":"J Am Coll Cardiol"},{"key":"569_CR17","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/S0735-1097(01)01794-6","volume":"39","author":"SB Felix","year":"2002","unstructured":"Felix SB, Staudt A, Landsberger M, Grosse Y, Stangl V, Spielhagen T, Wallukat G, Wernecke KD, Baumann G, Stangl K (2002) Removal of cardiodepressant antibodies in dilated cardiomyopathy by immunoadsorption. J Am Coll Cardiol 39:646\u2013652. doi:10.1016\/S0735-1097(01)01794-6","journal-title":"J Am Coll Cardiol"},{"key":"569_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.healun.2008.11.910","volume":"28","author":"LE Felkin","year":"2009","unstructured":"Felkin LE, Lara-Pezzi E, George R, Yacoub MH, Birks EJ, Barton PJR (2009) Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device support. J Heart Lung Transpl 28:117\u2013122. doi:10.1016\/j.healun.2008.11.910","journal-title":"J Heart Lung Transpl"},{"key":"569_CR19","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s12265-011-9267-1","volume":"4","author":"LE Felkin","year":"2011","unstructured":"Felkin LE, Lara-Pezzi EA, Hall JL, Birks EJ, Barton PJ (2011) Reverse remodelling and recovery from heart failure are associated with complex patterns of gene expression. J Cardiovasc Transl Res 4:321\u2013331. doi:10.1007\/s12265-011-9267-1","journal-title":"J Cardiovasc Transl Res"},{"key":"569_CR20","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1161\/HYPERTENSIONAHA.112.193631","volume":"61","author":"IP Gladysheva","year":"2013","unstructured":"Gladysheva IP, Wang D, McNamee RA, Houng AK, Mohamad AA, Fan TM, Reed GL (2013) Corin overexpression improves cardiac function, heart failure, and survival in mice with dilated cardiomyopathy. Hypertension 61:327\u2013332. doi:10.1161\/HYPERTENSIONAHA.112.193631","journal-title":"Hypertension"},{"key":"569_CR21","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1161\/CIRCULATIONAHA.106.635664","volume":"114","author":"S Goser","year":"2006","unstructured":"Goser S, Andrassy M, Buss SJ, Leuschner F, Volz CH, Ottl R, Zittrich S, Blaudeck N, Hardt SE, Pfitzer G, Rose NR, Katus HA, Kaya Z (2006) Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium. Circulation 114:1693\u20131702. doi:10.1161\/CIRCULATIONAHA.106.635664","journal-title":"Circulation"},{"key":"569_CR22","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s00395-015-0517-2","volume":"110","author":"A Haghikia","year":"2015","unstructured":"Haghikia A, Kaya Z, Schwab J, Westenfeld R, Ehlermann P, Bachelier K, Oettl R, von Kaisenberg CS, Katus HA, Bauersachs J, Hilfiker-Kleiner D (2015) Evidence of autoantibodies against cardiac troponin I and sarcomeric myosin in peripartum cardiomyopathy. Basic Res Cardiol 110:60. doi:10.1007\/s00395-015-0517-2","journal-title":"Basic Res Cardiol"},{"key":"569_CR23","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.jacc.2010.11.010","volume":"57","author":"JL Hall","year":"2011","unstructured":"Hall JL, Fermin DR, Birks EJ, Barton PJ, Slaughter M, Eckman P, Baba HA, Wohlschlaeger J, Miller LW (2011) Clinical, molecular, and genomic changes in response to a left ventricular assist device. J Am Coll Cardiol 57:641\u2013652. doi:10.1016\/j.jacc.2010.11.010","journal-title":"J Am Coll Cardiol"},{"key":"569_CR24","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1021\/pr1008042","volume":"10","author":"E Hammer","year":"2011","unstructured":"Hammer E, Goritzka M, Ameling S, Darm K, Steil L, Klingel K, Trimpert C, Herda LR, Dorr M, Kroemer HK, Kandolf R, Staudt A, Felix SB, Volker U (2011) Characterization of the human myocardial proteome in inflammatory dilated cardiomyopathy by label-free quantitative shotgun proteomics of heart biopsies. J Proteome Res 10:2161\u20132171. doi:10.1021\/pr1008042","journal-title":"J Proteome Res"},{"key":"569_CR25","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurjhf\/hfn043","volume":"11","author":"S Heymans","year":"2009","unstructured":"Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, Cohen-Tervaert JW, Drexler H, Filippatos G, Felix SB, Gullestad L, Hilfiker-Kleiner D, Janssens S, Latini R, Neubauer G, Paulus WJ, Pieske B, Ponikowski P, Schroen B, Schultheiss HP, Tschope C, Van Bilsen M, Zannad F, McMurray J, Shah AM (2009) Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 11:119\u2013129. doi:10.1093\/eurjhf\/hfn043","journal-title":"Eur J Heart Fail"},{"key":"569_CR26","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.cardfail.2007.01.005","volume":"13","author":"S Iyengar","year":"2007","unstructured":"Iyengar S, Haas G, Lamba S, Orsinelli DA, Babu GJ, Ferketich AK, Yamokoski L, Periasamy M, Abraham WT (2007) Effect of cardiac resynchronization therapy on myocardial gene expression in patients with nonischemic dilated cardiomyopathy. J Card Fail 13:304\u2013311. doi:10.1016\/j.cardfail.2007.01.005","journal-title":"J Card Fail"},{"key":"569_CR27","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1172\/JCI200420149","volume":"113","author":"R Jahns","year":"2004","unstructured":"Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, Lohse MJ (2004) Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 113:1419\u20131429. doi:10.1172\/JCI200420149","journal-title":"J Clin Invest"},{"key":"569_CR28","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1080\/08916930802031603","volume":"41","author":"R Jahns","year":"2008","unstructured":"Jahns R, Vr Boivin, Schwarzbach V, Ertl G, Lohse MJ (2008) Pathological autoantibodies in cardiomyopathy. Autoimmunity 41:454\u2013461. doi:10.1080\/08916930802031603","journal-title":"Autoimmunity"},{"key":"569_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00392-007-0524-x","volume":"96","author":"A Kallwellis-Opara","year":"2007","unstructured":"Kallwellis-Opara A, Dorner A, Poller WC, Noutsias M, Kuhl U, Schultheiss HP, Pauschinger M (2007) Autoimmunological features in inflammatory cardiomyopathy. Clin Res Cardiol 96:469\u2013480. doi:10.1007\/s00392-007-0524-x","journal-title":"Clin Res Cardiol"},{"key":"569_CR30","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1161\/01.CIR.0000142607.33398.54","volume":"110","author":"N Katsuragi","year":"2004","unstructured":"Katsuragi N, Morishita R, Nakamura N, Ochiai T, Taniyama Y, Hasegawa Y, Kawashima K, Kaneda Y, Ogihara T, Sugimura K (2004) Periostin as a novel factor responsible for ventricular dilation. Circulation 110:1806\u20131813. doi:10.1161\/01.CIR.0000142607.33398.54","journal-title":"Circulation"},{"key":"569_CR31","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1161\/CIRCULATIONAHA.108.769489","volume":"118","author":"I Kindermann","year":"2008","unstructured":"Kindermann I, Kindermann M, Kandolf R, Klingel K, Bultmann B, Muller T, Lindinger A, Bohm M (2008) Predictors of outcome in patients with suspected myocarditis. Circulation 118:639\u2013648. doi:10.1161\/CIRCULATIONAHA.108.769489","journal-title":"Circulation"},{"key":"569_CR32","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.ijcard.2003.12.003","volume":"97","author":"F Knebel","year":"2004","unstructured":"Knebel F, Bohm M, Staudt A, Borges AC, Tepper M, Jochmann N, Wernicke KD, Felix S, Baumann G (2004) Reduction of morbidity by immunoadsorption therapy in patients with dilated cardiomyopathy. Int J Cardiol 97:517\u2013520. doi:10.1016\/j.ijcard.2003.12.003","journal-title":"Int J Cardiol"},{"key":"569_CR33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.cardfail.2013.01.013","volume":"19","author":"YE Koshman","year":"2013","unstructured":"Koshman YE, Patel N, Chu M, Iyengar R, Kim T, Ersahin C, Lewis W, Heroux A, Samarel AM (2013) Regulation of connective tissue growth factor gene expression and fibrosis in human heart failure. J Card Fail 19:283\u2013294. doi:10.1016\/j.cardfail.2013.01.013","journal-title":"J Card Fail"},{"key":"569_CR34","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.2165\/00003495-200969100-00001","volume":"69","author":"U K\u00fchl","year":"2009","unstructured":"K\u00fchl U, Schultheiss HP (2009) Viral myocarditis: diagnosis, aetiology and management. Drugs 69:1287\u20131302. doi:10.2165\/00003495-200969100-00001","journal-title":"Drugs"},{"key":"569_CR35","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00109-007-0249-3","volume":"86","author":"C Lang","year":"2008","unstructured":"Lang C, Sauter M, Szalay G, Racchi G, Grassi G, Rainaldi G, Mercatanti A, Lang F, Kandolf R, Klingel K (2008) Connective tissue growth factor: a crucial cytokine-mediating cardiac fibrosis in ongoing enterovirus myocarditis. J Mol Med 86:49\u201360. doi:10.1007\/s00109-007-0249-3","journal-title":"J Mol Med"},{"key":"569_CR36","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/ejcts\/ezu539","volume":"48","author":"SI Lok","year":"2015","unstructured":"Lok SI, Nous FM, van Kuik J, van der Weide P, Winkens B, Kemperman H, Huisman A, Lahpor JR, de Weger RA, de Jonge N (2015) Myocardial fibrosis and pro-fibrotic markers in end-stage heart failure patients during continuous-flow left ventricular assist device support. Eur J Cardiothorac Surg 48:407\u2013415. doi:10.1093\/ejcts\/ezu539","journal-title":"Eur J Cardiothorac Surg"},{"key":"569_CR37","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1056\/NEJMoa012630","volume":"346","author":"B Lowes","year":"2002","unstructured":"Lowes B, Gilbert E, Abraham W, Minobe W, Larrabee P, Ferguson D, Wolfel E, Lindenfeld J, Tsvetkova T, Robertson A, Quaife R, Bristow M (2002) Myocardial gene expression in dilated cardiomyopathy treated with beat-blocking agents. N Engl J Med 346:1357\u20131365. doi:10.1056\/NEJMoa012630","journal-title":"N Engl J Med"},{"key":"569_CR38","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1161\/CIRCULATIONAHA.105.606509","volume":"114","author":"H Mahrholdt","year":"2006","unstructured":"Mahrholdt H, Wagner A, Deluigi CC, Kispert E, Hager S, Meinhardt G, Vogelsberg H, Fritz P, Dippon J, Bock CT, Klingel K, Kandolf R, Sechtem U (2006) Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation 114:1581\u20131590. doi:10.1161\/CIRCULATIONAHA.105.606509","journal-title":"Circulation"},{"key":"569_CR39","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1161\/01.RES.0000159390.03503.c3","volume":"96","author":"KB Margulies","year":"2005","unstructured":"Margulies KB, Matiwala S, Cornejo C, Olsen H, Craven WA, Bednarik D (2005) Mixed messages\u2014transcription patterns in failing and recovering human myocardium. Circ Res 96:592\u2013599. doi:10.1161\/01.RES.0000159390.03503.e3","journal-title":"Circ Res"},{"key":"569_CR40","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","volume":"113","author":"BJ Maron","year":"2006","unstructured":"Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, Moss AJ, Seidman CE, Young JB (2006) Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 113:1807\u20131816. doi:10.1161\/CIRCULATIONAHA.106.174287","journal-title":"Circulation"},{"key":"569_CR41","doi-asserted-by":"publisher","first-page":"e0126707","DOI":"10.1371\/journal.pone.0126707","volume":"10","author":"KA Mueller","year":"2015","unstructured":"Mueller KA, Mueller II, Eppler D, Zuern CS, Seizer P, Kramer U, Koetter I, Roecken M, Kandolf R, Gawaz M, Geisler T, Henes JC, Klingel K (2015) Clinical and histopathological features of patients with systemic sclerosis undergoing endomyocardial biopsy. PLoS One 10:e0126707. doi:10.1371\/journal.pone.0126707","journal-title":"PLoS One"},{"key":"569_CR42","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.hrthm.2007.09.009","volume":"5","author":"W Mullens","year":"2008","unstructured":"Mullens W, Bartunek J, Wilson Tang WH, Delrue L, Herbots L, Willems R, De Bruyne B, Goethals M, Verstreken S, Vanderheyden M (2008) Early and late effects of cardiac resynchronization therapy on force-frequency relation and contractility regulating gene expression in heart failure patients. Heart Rhythm 5:52\u201359. doi:10.1016\/j.hrthm.2007.09.009","journal-title":"Heart Rhythm"},{"key":"569_CR43","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.cardiores.2005.10.001","volume":"69","author":"T Nishikimi","year":"2006","unstructured":"Nishikimi T, Maeda N, Matsuoka H (2006) The role of natriuretic peptides in cardioprotection. Cardiovasc Res 69:318\u2013328. doi:10.1016\/j.cardiores.2005.10.001","journal-title":"Cardiovasc Res"},{"key":"569_CR44","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1139\/y01-052","volume":"79","author":"Y Ogawa","year":"2001","unstructured":"Ogawa Y, Tamura N, Chusho H, Nakao K (2001) Brain natriuretic peptide appears to act locally as an antifibrotic factor in the heart. Can J Physiol Pharmacol 79:723\u2013729. doi:10.1139\/y01-052","journal-title":"Can J Physiol Pharmacol"},{"key":"569_CR45","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1038\/nm955","volume":"9","author":"T Okazaki","year":"2003","unstructured":"Okazaki T, Tanaka Y, Nishio R, Mitsuiye T, Mizoguchi A, Wang J, Ishida M, Hiai H, Matsumori A, Minato N, Honjo T (2003) Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat Med 9:1477\u20131483. doi:10.1038\/nm955","journal-title":"Nat Med"},{"key":"569_CR46","doi-asserted-by":"publisher","first-page":"82","DOI":"10.2174\/1568026611313020002","volume":"13","author":"V Panagopoulou","year":"2013","unstructured":"Panagopoulou V, Deftereos S, Kossyvakis C, Raisakis K, Giannopoulos G, Bouras G, Pyrgakis V, Cleman MW (2013) NTproBNP: an important biomarker in cardiac diseases. Curr Top Med Chem 13:82\u201394. doi:10.2174\/1568026611313020002","journal-title":"Curr Top Med Chem"},{"key":"569_CR47","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1053\/euhj.2001.2783","volume":"22","author":"WJ Remme","year":"2001","unstructured":"Remme WJ, Swedberg K (2001) Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J 22:1527\u20131560. doi:10.1053\/euhj.2001.2783","journal-title":"Eur Heart J"},{"key":"569_CR48","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/clpt.2009.246","volume":"87","author":"A Staudt","year":"2010","unstructured":"Staudt A, Herda LR, Trimpert C, Lubenow L, Landsberger M, Dorr M, Hummel A, Eckerle LG, Beug D, Muller C, Hoffmann W, Weitmann K, Klingel K, Kandolf R, Kroemer HK, Greinacher A, Felix SB (2010) Fcgamma-receptor IIa polymorphism and the role of immunoadsorption in cardiac dysfunction in patients with dilated cardiomyopathy. Clin Pharmacol Ther 87:452\u2013458. doi:10.1038\/clpt.2009.246","journal-title":"Clin Pharmacol Ther"},{"key":"569_CR49","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.ahj.2006.06.027","volume":"152","author":"A Staudt","year":"2006","unstructured":"Staudt A, Hummel A, Ruppert J, Dorr M, Trimpert C, Birkenmeier K, Krieg T, Staudt Y, Felix SB (2006) Immunoadsorption in dilated cardiomyopathy: 6-month results from a randomized study. Am Heart J 152:712\u2013716. doi:10.1016\/j.ahj.2006.06.027","journal-title":"Am Heart J"},{"key":"569_CR50","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.1161\/01.CIR.103.22.2681","volume":"103","author":"A Staudt","year":"2001","unstructured":"Staudt A, Schaper F, Stangl V, Plagemann A, Bohm M, Merkel K, Wallukat G, Wernecke KD, Stangl K, Baumann G, Felix SB (2001) Immunohistological changes in dilated cardiomyopathy induced by immunoadsorption therapy and subsequent immunoglobulin substitution. Circulation 103:2681\u20132686. doi:10.1161\/01.CIR.103.22.2681","journal-title":"Circulation"},{"key":"569_CR51","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/1467-9868.00346","volume":"64","author":"J Storey","year":"2002","unstructured":"Storey J (2002) A direct approach to false discovery rates. J R Stat Soc B 64:479\u2013498. doi:10.1111\/1467-9868.00346","journal-title":"J R Stat Soc B"},{"key":"569_CR52","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1093\/eurheartj\/ehi166","volume":"26","author":"K Swedberg","year":"2005","unstructured":"Swedberg K, Cleland J, Dargie H, Drexler H, Follath F, Komajda M, Tavazzi L, Smiseth OA, Gavazzi A, Haverich A, Hoes A, Jaarsma T, Korewicki J, Levy S, Linde C, Lopez-Sendon JL, Nieminen MS, Pierard L, Remme WJ (2005) Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): the Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J 26:1115\u20131140. doi:10.1093\/eurheartj\/ehi204","journal-title":"Eur Heart J"},{"key":"569_CR53","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jacc.2007.07.087","volume":"51","author":"M Vanderheyden","year":"2008","unstructured":"Vanderheyden M, Mullens W, Delrue L, Goethals M, de Bruyne B, Wijns W, Geelen P, Verstreken S, Wellens F, Bartunek J (2008) Myocardial gene expression in heart failure patients treated with cardiac resynchronization therapy responders versus nonresponders. J Am Coll Cardiol 51:129\u2013136. doi:10.1016\/j.jacc.2007.07.087","journal-title":"J Am Coll Cardiol"},{"key":"569_CR54","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.cardfail.2007.10.016","volume":"14","author":"M Vanderheyden","year":"2008","unstructured":"Vanderheyden M, Mullens W, Delrue L, Goethals M, Verstreken S, Wijns W, de Bruyne B, Bartunek J (2008) Endomyocardial upregulation of beta1 adrenoreceptor gene expression and myocardial contractile reserve following cardiac resynchronization therapy. J Card Fail 14:172\u2013178. doi:10.1016\/j.cardfail.2007.10.016","journal-title":"J Card Fail"},{"key":"569_CR55","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.peptides.2004.08.034","volume":"26","author":"AM Vollmar","year":"2005","unstructured":"Vollmar AM (2005) The role of atrial natriuretic peptide in the immune system. Peptides 26:1086\u20131094. doi:10.1016\/j.peptides.2004.08.034","journal-title":"Peptides"},{"key":"569_CR56","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1136\/hrt.2008.164145","volume":"96","author":"YO Xu-Cai","year":"2010","unstructured":"Xu-Cai YO, Wu Q (2010) Molecular forms of natriuretic peptides in heart failure and their implications. Heart 96:419\u2013424. doi:10.1136\/hrt.2008.164145","journal-title":"Heart"},{"key":"569_CR57","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.jjcc.2013.09.013","volume":"63","author":"S Zhao","year":"2014","unstructured":"Zhao S, Wu H, Xia W, Chen X, Zhu S, Zhang S, Shao Y, Ma W, Yang D, Zhang J (2014) Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts. J Cardiol 63:373\u2013378. doi:10.1016\/j.jjcc.2013.09.013","journal-title":"J Cardiol"},{"key":"569_CR58","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0871-y","author":"CS Zuern","year":"2015","unstructured":"Zuern CS, Walker B, Sauter M, Schaub M, Chatterjee M, Mueller K, Rath D, Vogel S, Tegtmeyer R, Seizer P, Geisler T, Kandolf R, Lang F, Klingel K, Gawaz M, Borst O (2015) Endomyocardial expression of SDF-1 predicts mortality in patients with suspected myocarditis. Clin Res Cardiol. doi:10.1007\/s00392-015-0871-y","journal-title":"Clin Res Cardiol"}],"updated-by":[{"DOI":"10.1007\/s00395-017-0627-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000}}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-016-0569-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-016-0569-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-016-0569-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T01:49:38Z","timestamp":1744163378000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-016-0569-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,13]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["569"],"URL":"https:\/\/doi.org\/10.1007\/s00395-016-0569-y","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00395-017-0627-0","asserted-by":"object"}]},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,13]]},"assertion":[{"value":"10 December 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Written informed consent was obtained by each patient and the protocol was approved by the Ethics Committee of the University of Greifswald, Germany (Reg.-Nr.: III UV 34\/04). The investigation conforms to the principles of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"S.B.F. received research support and speaker fees from Fresenius Medical Care. All other authors declare they have no competing interests, or other interests that might be perceived to influence the results and discussion reported in this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"53"}}