{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:37:16Z","timestamp":1791308236117,"version":"4.3.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T00:00:00Z","timestamp":1497657600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006020","name":"Center for Translational Molecular Medicine","doi-asserted-by":"publisher","award":["01C-203"],"award-info":[{"award-number":["01C-203"]}],"id":[{"id":"10.13039\/501100006020","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s00395-017-0636-z","type":"journal-article","created":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T05:49:38Z","timestamp":1497678578000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Deleterious acute and chronic effects of bradycardic right ventricular apex pacing: consequences for arrhythmic outcome"],"prefix":"10.1007","volume":"112","author":[{"given":"T. R. G.","family":"Stams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dunnink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. M.","family":"van Everdingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. D. M.","family":"Beekman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"van der Nagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F. A.","family":"Bierhuizen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Meine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,17]]},"reference":[{"key":"636_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s12265-012-9348-9","volume":"5","author":"T Aiba","year":"2012","unstructured":"Aiba T, Tomaselli G (2012) Electrical remodeling in dyssynchrony and resynchronization. J Cardiovasc Transl Res 5:170\u2013179. doi:\n                        10.1007\/s12265-012-9348-9","journal-title":"J Cardiovasc Transl Res"},{"key":"636_CR2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ijcard.2014.03.079","volume":"173","author":"F Akerstrom","year":"2014","unstructured":"Akerstrom F, Pachon M, Puchol A, Jimenez-Lopez J, Segovia D, Rodriguez-Padial L, Arias MA (2014) Chronic right ventricular apical pacing: adverse effects and current therapeutic strategies to minimize them. Int J Cardiol 173:351\u2013360. doi:\n                        10.1016\/j.ijcard.2014.03.079","journal-title":"Int J Cardiol"},{"issue":"Suppl","key":"636_CR3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jelectrocard.2004.08.004","volume":"37","author":"C Antzelevitch","year":"2004","unstructured":"Antzelevitch C (2004) Arrhythmogenic mechanisms of QT prolonging drugs: is QT prolongation really the problem? J Electrocardiol 37(Suppl):15\u201324","journal-title":"J Electrocardiol"},{"key":"636_CR4","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1136\/hrt.2010.212381","volume":"97","author":"EY Birati","year":"2011","unstructured":"Birati EY, Belhassen B, Bardai A, Wilde AA, Viskin S (2011) The site of origin of torsade de pointes. Heart 97:1650\u20131654. doi:\n                        10.1136\/hrt.2010.212381","journal-title":"Heart"},{"key":"636_CR5","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.hrthm.2006.05.027","volume":"3","author":"R Coronel","year":"2006","unstructured":"Coronel R, de Bakker JM, Wilms-Schopman FJ, Opthof T, Linnenbank AC, Belterman CN, Janse MJ (2006) Monophasic action potentials and activation recovery intervals as measures of ventricular action potential duration: experimental evidence to resolve some controversies. Heart Rhythm 3:1043\u20131050. doi:\n                        10.1016\/j.hrthm.2006.05.027","journal-title":"Heart Rhythm"},{"key":"636_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1161\/CIRCEP.108.814608","volume":"2","author":"V Delgado","year":"2009","unstructured":"Delgado V, Tops LF, Trines SA, Zeppenfeld K, Marsan NA, Bertini M, Holman ER, Schalij MJ, Bax JJ (2009) Acute effects of right ventricular apical pacing on left ventricular synchrony and mechanics. Circ Arrhythm Electrophysiol 2:135\u2013145. doi:\n                        10.1161\/CIRCEP.108.814608","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"Pt 3","key":"636_CR7","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1113\/jphysiol.1994.sp020209","volume":"477","author":"T Delhaas","year":"1994","unstructured":"Delhaas T, Arts T, Prinzen FW, Reneman RS (1994) Regional fibre stress-fibre strain area as an estimate of regional blood flow and oxygen demand in the canine heart. J Physiol 477(Pt 3):481\u2013496. doi:\n                        10.1113\/jphysiol.1994.sp020209","journal-title":"J Physiol"},{"key":"636_CR8","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1093\/europace\/euw087","volume":"19","author":"A Dunnink","year":"2017","unstructured":"Dunnink A, Stams TRG, Bossu A, Meijborg VMF, Beekman JDM, Wijers SC, De Bakker JMT, Vos MA (2017) Torsade de pointes arrhythmias arise at the site of maximal heterogeneity of repolarization in the chronic complete atrioventricular block dog. Europace 19:858\u2013865. doi:\n                        10.1093\/europace\/euw087","journal-title":"Europace"},{"key":"636_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/j.1540-8167.2007.01079.x","volume":"19","author":"BK Fornwalt","year":"2008","unstructured":"Fornwalt BK, Cummings RM, Arita T, Delfino JG, Fyfe DA, Campbell RM, Strieper MJ, Oshinski JN, Frias PA (2008) Acute pacing-induced dyssynchronous activation of the left ventricle creates systolic dyssynchrony with preserved diastolic synchrony. J Cardiovasc Electrophysiol 19:483\u2013488. doi:\n                        10.1111\/j.1540-8167.2007.01079.x","journal-title":"J Cardiovasc Electrophysiol"},{"key":"636_CR10","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1038\/sj.bjp.0707673","volume":"153","author":"G Heusch","year":"2008","unstructured":"Heusch G (2008) Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents. Br J Pharmacol 153:1589\u20131601. doi:\n                        10.1038\/sj.bjp.0707673","journal-title":"Br J Pharmacol"},{"key":"636_CR11","doi-asserted-by":"publisher","first-page":"H410","DOI":"10.1152\/ajpheart.00213.2013","volume":"305","author":"D Jeyaraj","year":"2013","unstructured":"Jeyaraj D, Wan X, Ficker E, Stelzer JE, Deschenes I, Liu H, Wilson LD, Decker KF, Said TH, Jain MK, Rudy Y, Rosenbaum DS (2013) Ionic bases for electrical remodeling of the canine cardiac ventricle. Am J Physiol Heart Circ Physiol 305:H410\u2013H419. doi:\n                        10.1152\/ajpheart.00213.2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"636_CR12","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1161\/CIRCULATIONAHA.107.688317","volume":"115","author":"D Jeyaraj","year":"2007","unstructured":"Jeyaraj D, Wilson LD, Zhong J, Flask C, Saffitz JE, Deschenes I, Yu X, Rosenbaum DS (2007) Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Circulation 115:3145\u20133155. doi:\n                        10.1161\/CIRCULATIONAHA.107.688317","journal-title":"Circulation"},{"key":"636_CR13","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1016\/j.hrthm.2016.09.027","volume":"13","author":"EL Kiehl","year":"2016","unstructured":"Kiehl EL, Makki T, Kumar R, Gumber D, Kwon DH, Rickard JW, Kanj M, Wazni OM, Saliba WI, Varma N, Wilkoff BL, Cantillon DJ (2016) Incidence and predictors of right ventricular pacing-induced cardiomyopathy in patients with complete atrioventricular block and preserved left ventricular systolic function. Heart Rhythm 13:2272\u20132278. doi:\n                        10.1016\/j.hrthm.2016.09.027","journal-title":"Heart Rhythm"},{"key":"636_CR14","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.echo.2007.08.045","volume":"21","author":"WH Liu","year":"2008","unstructured":"Liu WH, Chen MC, Chen YL, Guo BF, Pan KL, Yang CH, Chang HW (2008) Right ventricular apical pacing acutely impairs left ventricular function and induces mechanical dyssynchrony in patients with sick sinus syndrome: a real-time three-dimensional echocardiographic study. J Am Soc Echocardiogr 21:224\u2013229. doi:\n                        10.1016\/j.echo.2007.08.045","journal-title":"J Am Soc Echocardiogr"},{"key":"636_CR15","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408. doi:\n                        10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"636_CR16","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1161\/CIRCEP.109.882910","volume":"2","author":"RW Mills","year":"2009","unstructured":"Mills RW, Cornelussen RN, Mulligan LJ, Strik M, Rademakers LM, Skadsberg ND, van Hunnik A, Kuiper M, Lampert A, Delhaas T, Prinzen FW (2009) Left ventricular septal and left ventricular apical pacing chronically maintain cardiac contractile coordination, pump function and efficiency. Circ Arrhythm Electrophysiol 2:571\u2013579. doi:\n                        10.1161\/CIRCEP.109.882910","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"636_CR17","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1111\/j.1540-8159.2011.03150.x","volume":"34","author":"HG Mond","year":"2011","unstructured":"Mond HG, Proclemer A (2011) The 11th world survey of cardiac pacing and implantable cardioverter-defibrillators: calendar year 2009\u2014a World Society of Arrhythmia\u2019s project. Pacing Clin Electrophysiol 34:1013\u20131027. doi:\n                        10.1111\/j.1540-8159.2011.03150.x","journal-title":"Pacing Clin Electrophysiol"},{"key":"636_CR18","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1161\/01.CIR.85.3.1125","volume":"85","author":"S Ono","year":"1992","unstructured":"Ono S, Nohara R, Kambara H, Okuda K, Kawai C (1992) Regional myocardial perfusion and glucose metabolism in experimental left bundle branch block. Circulation 85:1125\u20131131. doi:\n                        10.1161\/01.CIR.85.3.1125","journal-title":"Circulation"},{"key":"636_CR19","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.pharmthera.2008.03.006","volume":"119","author":"A Oros","year":"2008","unstructured":"Oros A, Beekman JD, Vos MA (2008) The canine model with chronic, complete atrio-ventricular block. Pharmacol Ther 119:168\u2013178. doi:\n                        10.1016\/j.pharmthera.2008.03.006","journal-title":"Pharmacol Ther"},{"key":"636_CR20","first-page":"H300","volume":"259","author":"FW Prinzen","year":"1990","unstructured":"Prinzen FW, Augustijn CH, Arts T, Allessie MA, Reneman RS (1990) Redistribution of myocardial fiber strain and blood flow by asynchronous activation. Am J Physiol 259:H300\u2013H308","journal-title":"Am J Physiol"},{"key":"636_CR21","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1016\/S0735-1097(99)00068-6","volume":"33","author":"FW Prinzen","year":"1999","unstructured":"Prinzen FW, Hunter WC, Wyman BT, McVeigh ER (1999) Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging. J Am Coll Cardiol 33:1735\u20131742. doi:\n                        10.1016\/S0735-1097(99)00068-6","journal-title":"J Am Coll Cardiol"},{"key":"636_CR22","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0008-6363(02)00717-4","volume":"57","author":"C Ramakers","year":"2003","unstructured":"Ramakers C, Vos MA, Doevendans PA, Schoenmakers M, Wu YS, Scicchitano S, Iodice A, Thomas GP, Antzelevitch C, Dumaine R (2003) Coordinated down-regulation of KCNQ1 and KCNE1 expression contributes to reduction of I(Ks) in canine hypertrophied hearts. Cardiovasc Res 57:486\u2013496","journal-title":"Cardiovasc Res"},{"key":"636_CR23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bdq.2015.07.001","volume":"5","author":"JM Ruijter","year":"2015","unstructured":"Ruijter JM, Ruiz Villalba A, Hellemans J, Untergasser A, van den Hoff MJ (2015) Removal of between-run variation in a multi-plate qPCR experiment. Biomol Detect Quantif 5:10\u201314. doi:\n                        10.1016\/j.bdq.2015.07.001","journal-title":"Biomol Detect Quantif"},{"key":"636_CR24","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cardiores.2005.03.008","volume":"67","author":"DD Spragg","year":"2005","unstructured":"Spragg DD, Akar FG, Helm RH, Tunin RS, Tomaselli GF, Kass DA (2005) Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts. Cardiovasc Res 67:77\u201386. doi:\n                        10.1016\/j.cardiores.2005.03.008","journal-title":"Cardiovasc Res"},{"key":"636_CR25","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1161\/01.CIR.0000072769.17295.B1","volume":"107","author":"MO Sweeney","year":"2003","unstructured":"Sweeney MO, Hellkamp AS, Ellenbogen KA, Greenspon AJ, Freedman RA, Lee KL, Lamas GA, Investigators MOST (2003) Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation 107:2932\u20132937. doi:\n                        10.1161\/01.CIR.0000072769.17295.B1","journal-title":"Circulation"},{"key":"636_CR26","doi-asserted-by":"publisher","first-page":"3766","DOI":"10.1161\/01.CIR.0000150336.86033.8D","volume":"110","author":"JB Thambo","year":"2004","unstructured":"Thambo JB, Bordachar P, Garrigue S, Lafitte S, Sanders P, Reuter S, Girardot R, Crepin D, Reant P, Roudaut R, Jais P, Haissaguerre M, Clementy J, Jimenez M (2004) Detrimental ventricular remodeling in patients with congenital complete heart block and chronic right ventricular apical pacing. Circulation 110:3766\u20133772. doi:\n                        10.1161\/01.CIR.0000150336.86033.8D","journal-title":"Circulation"},{"key":"636_CR27","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.cardiores.2006.11.025","volume":"73","author":"MB Thomsen","year":"2007","unstructured":"Thomsen MB, Oros A, Schoenmakers M, van Opstal JM, Maas JN, Beekman JD, Vos MA (2007) Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation. Cardiovasc Res 73:521\u2013530. doi:\n                        10.1016\/j.cardiores.2006.11.025","journal-title":"Cardiovasc Res"},{"key":"636_CR28","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.jacc.2009.06.006","volume":"54","author":"LF Tops","year":"2009","unstructured":"Tops LF, Schalij MJ, Bax JJ (2009) The effects of right ventricular apical pacing on ventricular function and dyssynchrony implications for therapy. J Am Coll Cardiol 54:764\u2013776. doi:\n                        10.1016\/j.jacc.2009.06.006","journal-title":"J Am Coll Cardiol"},{"key":"636_CR29","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1161\/01.CIR.98.6.588","volume":"98","author":"MF Oosterhout van","year":"1998","unstructured":"van Oosterhout MF, Prinzen FW, Arts T, Schreuder JJ, Vanagt WY, Cleutjens JP, Reneman RS (1998) Asynchronous electrical activation induces asymmetrical hypertrophy of the left ventricular wall. Circulation 98:588\u2013595. doi:\n                        10.1161\/01.CIR.98.6.588","journal-title":"Circulation"},{"key":"636_CR30","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1161\/hc4701.099579","volume":"104","author":"JM Opstal van","year":"2001","unstructured":"van Opstal JM, Schoenmakers M, Verduyn SC, de Groot SH, Leunissen JD, van Der Hulst FF, Molenschot MM, Wellens HJ, Vos MA (2001) Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long-QT syndrome. Circulation 104:2722\u20132727","journal-title":"Circulation"},{"key":"636_CR31","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.amjcard.2005.11.044","volume":"97","author":"K Vernooy","year":"2006","unstructured":"Vernooy K, Dijkman B, Cheriex EC, Prinzen FW, Crijns HJ (2006) Ventricular remodeling during long-term right ventricular pacing following His bundle ablation. Am J Cardiol 97:1223\u20131227. doi:\n                        10.1016\/j.amjcard.2005.11.044","journal-title":"Am J Cardiol"},{"key":"636_CR32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/eurheartj\/ehi008","volume":"26","author":"K Vernooy","year":"2005","unstructured":"Vernooy K, Verbeek XA, Peschar M, Crijns HJ, Arts T, Cornelussen RN, Prinzen FW (2005) Left bundle branch block induces ventricular remodelling and functional septal hypoperfusion. Eur Heart J 26:91\u201398. doi:\n                        10.1093\/eurheartj\/ehi008","journal-title":"Eur Heart J"},{"key":"636_CR33","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1161\/01.CIR.100.24.2455","volume":"100","author":"PG Volders","year":"1999","unstructured":"Volders PG, Sipido KR, Vos MA, Spatjens RL, Leunissen JD, Carmeliet E, Wellens HJ (1999) Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes. Circulation 100:2455\u20132461. doi:\n                        10.1161\/01.CIR.100.24.2455","journal-title":"Circulation"},{"key":"636_CR34","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1161\/01.CIR.98.11.1125","volume":"98","author":"MA Vos","year":"1998","unstructured":"Vos MA, de Groot SH, Verduyn SC, van der Zande J, Leunissen HD, Cleutjens JP, van Bilsen M, Daemen MJ, Schreuder JJ, Allessie MA, Wellens HJ (1998) Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling. Circulation 98:1125\u20131135. doi:\n                        10.1161\/01.CIR.98.11.1125","journal-title":"Circulation"},{"key":"636_CR35","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1001\/jama.288.24.3115","volume":"288","author":"BL Wilkoff","year":"2002","unstructured":"Wilkoff BL, Cook JR, Epstein AE, Greene HL, Hallstrom AP, Hsia H, Kutalek SP, Sharma A, Dual C, Investigators VVIIDT (2002) Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the dual chamber and VVI implantable defibrillator (DAVID) trial. JAMA 288:3115\u20133123. doi:\n                        10.1001\/jama.288.24.3115","journal-title":"JAMA"},{"key":"636_CR36","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.jacc.2007.05.019","volume":"50","author":"SK Winckels","year":"2007","unstructured":"Winckels SK, Thomsen MB, Oosterhoff P, Oros A, Beekman JD, Attevelt NJ, Kretzers L, Vos MA (2007) High-septal pacing reduces ventricular electrical remodeling and proarrhythmia in chronic atrioventricular block dogs. J Am Coll Cardiol 50:906\u2013913. doi:\n                        10.1016\/j.jacc.2007.05.019","journal-title":"J Am Coll Cardiol"},{"key":"636_CR37","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.mbs.2010.08.007","volume":"228","author":"M Zaniboni","year":"2010","unstructured":"Zaniboni M, Riva I, Cacciani F, Groppi M (2010) How different two almost identical action potentials can be: a model study on cardiac repolarization. Math Biosci 228:56\u201370. doi:\n                        10.1016\/j.mbs.2010.08.007","journal-title":"Math Biosci"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00395-017-0636-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-017-0636-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-017-0636-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T03:25:19Z","timestamp":1500866719000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00395-017-0636-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,17]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["636"],"URL":"https:\/\/doi.org\/10.1007\/s00395-017-0636-z","relation":{},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,17]]},"article-number":"46"}}