{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:18:41Z","timestamp":1779121121379,"version":"3.51.4"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1007\/s00395-017-0640-3","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T02:48:40Z","timestamp":1499395720000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Animal models of arrhythmogenic right ventricular cardiomyopathy: what have we learned and where do we go? Insight for therapeutics"],"prefix":"10.1007","volume":"112","author":[{"given":"Laura","family":"Padr\u00f3n-Barthe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Garcia-Pavia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Lara-Pezzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"640_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/ng1294","volume":"36","author":"Y Asano","year":"2004","unstructured":"Asano Y, Takashima S, Asakura M, Shintani Y, Liao Y, Minamino T, Asanuma H, Sanada S, Kim J, Ogai A, Fukushima T, Oikawa Y, Okazaki Y, Kaneda Y, Sato M, Miyazaki J, Kitamura S, Tomoike H, Kitakaze M, Hori M (2004) Lamr1 functional retroposon causes right ventricular dysplasia in mice. Nat Genet 36:123\u2013130. doi: 10.1038\/ng1294","journal-title":"Nat Genet"},{"key":"640_CR2","doi-asserted-by":"publisher","first-page":"240ra74","DOI":"10.1126\/scitranslmed.3008008","volume":"6","author":"A Asimaki","year":"2014","unstructured":"Asimaki A, Kapoor S, Plovie E, Karin Arndt A, Adams E, Liu Z, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae CA, Kleber AG, Saffitz JE (2014) Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy. Sci Transl Med 6:240ra74. doi: 10.1126\/scitranslmed.3008008","journal-title":"Sci Transl Med"},{"key":"640_CR3","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/S0140-6736(09)60256-7","volume":"373","author":"C Basso","year":"2009","unstructured":"Basso C, Corrado D, Marcus FI, Nava A, Thiene G (2009) Arrhythmogenic right ventricular cardiomyopathy. Lancet 373:1289\u20131300. doi: 10.1016\/S0140-6736(09)60256-7","journal-title":"Lancet"},{"key":"640_CR4","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1161\/01.CIR.0000118494.07530.65","volume":"109","author":"C Basso","year":"2004","unstructured":"Basso C, Fox PR, Meurs KM, Towbin JA, Spier AW, Calabrese F, Maron BJ, Thiene G (2004) Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs: a new animal model of human disease. Circulation 109:1180\u20131185. doi: 10.1161\/01.CIR.0000118494.07530.65","journal-title":"Circulation"},{"key":"640_CR5","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1161\/01.CIR.94.5.983","volume":"94","author":"C Basso","year":"1996","unstructured":"Basso C, Thiene G, Corrado D, Angelini A, Nava A, Valente M (1996) Arrhythmogenic right ventricular cardiomyopathy: dysplasia, dystrophy, or myocarditis? Circulation 94:983\u2013991. doi: 10.1161\/01.CIR.94.5.983","journal-title":"Circulation"},{"key":"640_CR6","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1006\/dbio.1996.0346","volume":"180","author":"C Bierkamp","year":"1996","unstructured":"Bierkamp C, Mclaughlin KJ, Schwarz H, Huber O, Kemler R (1996) Embryonic heart and skin defects in mice lacking plakoglobin. Dev Biol 180:780\u2013785. doi: 10.1006\/dbio.1996.0346","journal-title":"Dev Biol"},{"key":"640_CR7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1242\/dev.126.2.371","volume":"126","author":"C Bierkamp","year":"1999","unstructured":"Bierkamp C, Schwarz H, Huber O, Kemler R (1999) Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice. Development 126:371\u2013381","journal-title":"Development"},{"key":"640_CR8","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1111\/j.1600-0625.2009.00908.x","volume":"18","author":"MC Bolling","year":"2009","unstructured":"Bolling MC, Jonkman MF (2009) Skin and heart: une liaison dangereuse. Exp Dermatol 18:658\u2013668. doi: 10.1111\/j.1600-0625.2009.00908.x","journal-title":"Exp Dermatol"},{"key":"640_CR9","doi-asserted-by":"publisher","first-page":"e0174019","DOI":"10.1371\/journal.pone.0174019","volume":"12","author":"A Brodehl","year":"2017","unstructured":"Brodehl A, Belke DD, Garnett L, Martens K, Abdelfatah N, Rodriguez M, Diao C, Chen Y-X, Gordon PMK, Nygren A, Gerull B (2017) Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling. PLoS One 12:e0174019. doi: 10.1371\/journal.pone.0174019","journal-title":"PLoS One"},{"key":"640_CR10","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1136\/vr.102821","volume":"176","author":"BM Cattanach","year":"2015","unstructured":"Cattanach BM, Dukes-McEwan J, Wotton PR, Stephenson HM, Hamilton RM (2015) A pedigree-based genetic appraisal of Boxer ARVC and the role of the Striatin mutation. Vet Rec 176:492. doi: 10.1136\/vr.102821","journal-title":"Vet Rec"},{"key":"640_CR11","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1093\/cvr\/cvs218","volume":"95","author":"M Cerrone","year":"2012","unstructured":"Cerrone M, Noorman M, Lin X, Chkourko H, Liang F-X, van der Nagel R, Hund T, Birchmeier W, Mohler P, van Veen TA, van Rijen HV, Delmar M (2012) Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency. Cardiovasc Res 95:460\u2013468. doi: 10.1093\/cvr\/cvs218","journal-title":"Cardiovasc Res"},{"key":"640_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/jci.insight.85923","volume":"1","author":"SP Chelko","year":"2016","unstructured":"Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R, MacRae CA, Leber R, Kleber AG, Saffitz JE, Judge DP (2016) Central role for GSK3\u03b2 in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight 1:1\u201320. doi: 10.1172\/jci.insight.85923","journal-title":"JCI Insight"},{"key":"640_CR13","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1161\/CIRCRESAHA.114.302810","volume":"114","author":"SN Chen","year":"2014","unstructured":"Chen SN, Gurha P, Lombardi R, Ruggiero A, Willerson JT, Marian AJ (2014) The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy. Circ Res 114:454\u2013468. doi: 10.1161\/CIRCRESAHA.114.302810","journal-title":"Circ Res"},{"key":"640_CR14","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1161\/CIRCULATIONAHA.109.913871","volume":"122","author":"D Corrado","year":"2010","unstructured":"Corrado D, Calkins H, Link MS, Leoni L, Favale S, Bevilacqua M, Basso C, Ward D, Boriani G, Ricci R, Piccini JP, Dalal D, Santini M, Buja G, Iliceto S, Estes NAM, Wichter T, McKenna WJ, Thiene G, Marcus FI (2010) Prophylactic implantable defibrillator in patients with arrhythmogenic right ventricular cardiomyopathy\/dysplasia and no prior ventricular fibrillation or sustained ventricular tachycardia. Circulation 122:1144\u20131152. doi: 10.1161\/CIRCULATIONAHA.109.913871","journal-title":"Circulation"},{"key":"640_CR15","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1540-8167.2000.tb00059.x","volume":"11","author":"D Corrado","year":"2000","unstructured":"Corrado D, Fontaine G, Marcus FI, McKenna WJ, Nava A, Thiene G, Wichter T (2000) Arrhythmogenic right ventricular dysplasia\/cardiomyopathy: need for an international registry. European Society of Cardiology and the Scientific Council on Cardiomyopathies of the World Heart Federation. J Cardiovasc Electrophysiol 11:827\u2013832","journal-title":"J Cardiovasc Electrophysiol"},{"key":"640_CR16","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1161\/01.CIR.0000103130.33451.D2","volume":"108","author":"D Corrado","year":"2003","unstructured":"Corrado D, Leoni L, Link MS, Della Bella P, Gaita F, Curnis A, Salerno JU, Igidbashian D, Raviele A, Disertori M, Zanotto G, Verlato R, Vergara G, Delise P, Turrini P, Basso C, Naccarella F, Maddalena F, Estes NAM, Buja G, Thiene G (2003) Implantable cardioverter-defibrillator therapy for prevention of sudden death in patients with arrhythmogenic right ventricular cardiomyopathy\/dysplasia. Circulation 108:3084\u20133091. doi: 10.1161\/01.CIR.0000103130.33451.D2","journal-title":"Circulation"},{"key":"640_CR17","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1056\/NEJMra1509267","volume":"376","author":"D Corrado","year":"2017","unstructured":"Corrado D, Link MS, Calkins H (2017) Arrhythmogenic right ventricular cardiomyopathy. N Engl J Med 376:61\u201372. doi: 10.1056\/NEJMra1509267","journal-title":"N Engl J Med"},{"key":"640_CR18","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1016\/j.jacc.2015.01.045","volume":"65","author":"FM Cruz","year":"2015","unstructured":"Cruz FM, Sanz-Rosa D, Roche-Molina M, Garc\u00eda-Prieto J, Garc\u00eda-Ruiz JM, Pizarro G, Jim\u00e9nez-Borreguero LJ, Torres M, Bernad A, Ru\u00edz-Cabello J, Fuster V, Ib\u00e1\u00f1ez B, Bernal JA (2015) Exercise triggers ARVC phenotype in mice expressing a disease-causing mutated version of human plakophilin-2. J Am Coll Cardiol 65:1438\u20131450. doi: 10.1016\/j.jacc.2015.01.045","journal-title":"J Am Coll Cardiol"},{"key":"640_CR19","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/CIRCRESAHA.111.263939","volume":"110","author":"M Denegri","year":"2012","unstructured":"Denegri M, Avelino-Cruz JE, Boncompagni S, De Simone SA, Auricchio A, Villani L, Volpe P, Protasi F, Napolitano C, Priori SG (2012) Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias. Circ Res 110:663\u2013668. doi: 10.1161\/CIRCRESAHA.111.263939","journal-title":"Circ Res"},{"key":"640_CR20","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1161\/CIRCULATIONAHA.113.006901","volume":"129","author":"M Denegri","year":"2014","unstructured":"Denegri M, Bongianino R, Lodola F, Boncompagni S, De Giusti VC, Avelino-Cruz J, Liu N, Persampieri S, Curcio A, Esposito F, Pietrangelo L, Marty I, Villani L, Moyaho A, Baiardi P, Auricchio A, Protasi F, Napolitano C, Priori SG (2014) Single delivery of an adeno-associated viral construct to transfer the CASQ2 gene to knock-in mice affected by catecholaminergic polymorphic ventricular tachycardia is able to cure the disease from birth to advanced age. Circulation 129:2673\u20132681. doi: 10.1161\/CIRCULATIONAHA.113.006901","journal-title":"Circulation"},{"key":"640_CR21","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1078\/0171-9335-00278","volume":"81","author":"L Eshkind","year":"2002","unstructured":"Eshkind L, Tian Q, Schmidt A, Franke WW, Windoffer R, Leube RE (2002) Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells. Eur J Cell Biol 81:592\u2013598. doi: 10.1078\/0171-9335-00278","journal-title":"Eur J Cell Biol"},{"key":"640_CR22","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.jacc.2010.09.046","volume":"57","author":"L Fabritz","year":"2011","unstructured":"Fabritz L, Hoogendijk MG, Scicluna BP, Van Amersfoorth SCM, Fortmueller L, Wolf S, Laakmann S, Kreienkamp N, Piccini I, Breithardt G, Ruiz Noppinger P, Witt H, Ebnet K, Wichter T, Levkau B, Franke WW, Pieperhoff S, De Bakker JMT, Coronel R, Kirchhof P (2011) Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice. J Am Coll Cardiol 57:740\u2013750. doi: 10.1016\/j.jacc.2010.09.046","journal-title":"J Am Coll Cardiol"},{"key":"640_CR23","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1083\/jcb.143.7.2009","volume":"143","author":"GI Gallicano","year":"1998","unstructured":"Gallicano GI, Kouklis P, Bauer C, Yin M, Vasioukhin V, Degenstein L, Fuchs E (1998) Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol 143:2009\u20132022. doi: 10.1083\/jcb.143.7.2009","journal-title":"J Cell Biol"},{"key":"640_CR24","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1172\/JCI27751DS1","volume":"116","author":"E Garcia-gras","year":"2006","unstructured":"Garcia-gras E, Lombardi R, Giocondo MJ, Willerson JT, Schneider MD, Khoury DS, Marian AJ (2006) Suppression of canonical Wnt\/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Investig 116:2012\u20132021. doi: 10.1172\/JCI27751DS1","journal-title":"J Clin Investig"},{"key":"640_CR25","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1136\/hrt.2011.227967","volume":"97","author":"P Garcia-Pavia","year":"2011","unstructured":"Garcia-Pavia P, Syrris P, Salas C, Evans A, Mirelis JG, Cobo-Marcos M, Vilches C, Bornstein B, Segovia J, Alonso-Pulpon L, Elliott PM (2011) Desmosomal protein gene mutations in patients with idiopathic dilated cardiomyopathy undergoing cardiac transplantation: a clinicopathological study. Heart 97:1744\u20131752. doi: 10.1136\/hrt.2011.227967","journal-title":"Heart"},{"key":"640_CR26","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.bbamem.2007.07.014","volume":"1778","author":"D Garrod","year":"2008","unstructured":"Garrod D, Chidgey M (2008) Desmosome structure, composition and function. Biochim Biophys Acta 1778:572\u2013587. doi: 10.1016\/j.bbamem.2007.07.014","journal-title":"Biochim Biophys Acta"},{"key":"640_CR27","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1038\/ng1461","volume":"36","author":"B Gerull","year":"2004","unstructured":"Gerull B, Heuser A, Wichter T, Paul M, Basson CT, McDermott DA, Lerman BB, Markowitz SM, Ellinor PT, MacRae CA, Peters S, Grossmann KS, Michely B, Sasse-Klaassen S, Birchmeier W, Dietz R, Breithardt G, Schulze-Bahr E, Thierfelder L (2004) Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet 36:1162\u20131164. doi: 10.1038\/ng1461","journal-title":"Nat Genet"},{"key":"640_CR28","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1093\/eurheartj\/ehr472","volume":"33","author":"J Gomes","year":"2012","unstructured":"Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ, Tinker A, Lambiase PD (2012) Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Eur Heart J 33:1942\u20131953. doi: 10.1093\/eurheartj\/ehr472","journal-title":"Eur Heart J"},{"key":"640_CR29","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1126\/science.aad3456","volume":"351","author":"EM Green","year":"2016","unstructured":"Green EM, Wakimoto H, Anderson RL, Evanchik MJ, Gorham JM, Harrison BC, Henze M, Kawas R, Oslob JD, Rodriguez HM, Song Y, Wan W, Leinwand LA, Spudich JA, McDowell RS, Seidman JG, Seidman CE (2016) A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science 351:617\u2013621. doi: 10.1126\/science.aad3456","journal-title":"Science"},{"key":"640_CR30","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1083\/jcb.200402096","volume":"167","author":"KS Grossmann","year":"2004","unstructured":"Grossmann KS, Grund C, Huelsken J, Behrend M, Erdmann B, Franke WW, Birchmeier W (2004) Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol 167:149\u2013160. doi: 10.1083\/jcb.200402096","journal-title":"J Cell Biol"},{"key":"640_CR31","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0195-5616(91)50107-8","volume":"21","author":"NK Harpster","year":"1991","unstructured":"Harpster NK (1991) Boxer cardiomyopathy. A review of the long-term benefits of antiarrhythmic therapy. Vet Clin N Am Small Anim Pract 21:989\u20131004","journal-title":"Vet Clin N Am Small Anim Pract"},{"key":"640_CR32","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1093\/hmg\/ddi063","volume":"14","author":"BJ Herron","year":"2005","unstructured":"Herron BJ (2005) A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Hum Mol Genet 14:667\u2013677. doi: 10.1093\/hmg\/ddi063","journal-title":"Hum Mol Genet"},{"key":"640_CR33","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1086\/509044","volume":"79","author":"A Heuser","year":"2006","unstructured":"Heuser A, Plovie ER, Ellinor PT, Grossmann KS, Shin JT, Wichter T, Basson CT, Lerman BB, Sasse-Klaassen S, Thierfelder L, MacRae CA, Gerull B (2006) Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet 79:1081\u20131088. doi: 10.1086\/509044","journal-title":"Am J Hum Genet"},{"key":"640_CR34","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1016\/j.jacc.2013.06.033","volume":"62","author":"CA James","year":"2013","unstructured":"James CA, Bhonsale A, Tichnell C, Murray B, Russell SD, Tandri H, Tedford RJ, Judge DP, Calkins H (2013) Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia\/cardiomyopathy-associated desmosomal mutation carriers. J Am Coll Cardiol 62:1290\u20131297. doi: 10.1016\/j.jacc.2013.06.033","journal-title":"J Am Coll Cardiol"},{"key":"640_CR35","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1161\/CIRCGENETICS.114.000974","volume":"8","author":"S Kant","year":"2015","unstructured":"Kant S, Holth\u00f6fer B, Magin TM, Krusche CA, Leube RE (2015) Desmoglein 2-dependent arrhythmogenic cardiomyopathy is caused by a loss of adhesive function. Circ Cardiovasc Genet 8:553\u2013563. doi: 10.1161\/CIRCGENETICS.114.000974","journal-title":"Circ Cardiovasc Genet"},{"key":"640_CR36","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1161\/CIRCULATIONAHA.106.624502","volume":"114","author":"P Kirchhof","year":"2006","unstructured":"Kirchhof P, Fabritz L, Zwiener M, Witt H, Schafers M, Zellerhoff S, Paul M, Athai T, Hiller K-H, Baba HA, Breithardt G, Ruiz P, Wichter T, Levkau B (2006) Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice. Circulation 114:1799\u20131806. doi: 10.1161\/CIRCULATIONAHA.106.624502","journal-title":"Circulation"},{"key":"640_CR37","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1161\/01.CIR.103.4.485","volume":"103","author":"PJ Laitinen","year":"2001","unstructured":"Laitinen PJ, Brown KM, Piippo K, Swan H, Devaney JM, Brahmbhatt B, Donarum EA, Marino M, Tiso N, Viitasalo M, Toivonen L, Stephan D, Kontula K (2001) Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia. Circulation 103:485\u2013490. doi: 10.1161\/01.CIR.103.4.485","journal-title":"Circulation"},{"key":"640_CR38","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/humu.22765","volume":"36","author":"E Lazzarini","year":"2015","unstructured":"Lazzarini E, Jongbloed JDH, Pilichou K, Thiene G, Basso C, Bikker H, Charbon B, Swertz M, van Tintelen JP, van der Zwaag PA (2015) The ARVD\/C genetic variants database: 2014 update. Hum Mutat 36:403\u2013410. doi: 10.1002\/humu.22765","journal-title":"Hum Mutat"},{"key":"640_CR39","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1128\/MCB.01025-10","volume":"31","author":"J Li","year":"2011","unstructured":"Li J, Swope D, Raess N, Cheng L, Muller EJ, Radice GL (2011) Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of catenin signaling. Mol Cell Biol 31:1134\u20131144. doi: 10.1128\/MCB.01025-10","journal-title":"Mol Cell Biol"},{"key":"640_CR40","doi-asserted-by":"publisher","first-page":"e2393","DOI":"10.1038\/cddis.2016.304","volume":"7","author":"F Lodola","year":"2016","unstructured":"Lodola F, Morone D, Denegri M, Bongianino R, Nakahama H, Rutigliano L, Gosetti R, Rizzo G, Vollero A, Buonocore M, Napolitano C, Condorelli G, Priori SG, Di Pasquale E (2016) Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia. Cell Death Dis 7:e2393. doi: 10.1038\/cddis.2016.304","journal-title":"Cell Death Dis"},{"key":"640_CR41","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1093\/hmg\/ddt508","volume":"23","author":"RC Lyon","year":"2014","unstructured":"Lyon RC, Mezzano V, Wright AT, Pfeiffer E, Chuang J, Banares K, Castaneda A, Ouyang K, Cui L, Contu R, Gu Y, Evans SM, Omens JH, Peterson KL, McCulloch AD, Sheikh F (2014) Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Hum Mol Genet 23:1134\u20131150. doi: 10.1093\/hmg\/ddt508","journal-title":"Hum Mol Genet"},{"key":"640_CR42","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/carcin\/bgr309","volume":"33","author":"B Marchand","year":"2012","unstructured":"Marchand B, Tremblay I, Cagnol S, Boucher MJ (2012) Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms. Carcinogenesis 33:529\u2013537. doi: 10.1093\/carcin\/bgr309","journal-title":"Carcinogenesis"},{"key":"640_CR43","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/j.1542-474X.1999.tb00372.x","volume":"65","author":"FI Marcus","year":"1982","unstructured":"Marcus FI, Fontaine GH, Guiraudon G, Frank R, Laurenceau JL, Malergue C, Grosgogeat Y (1982) Right ventricular dysplasia: a report of 24 adult cases. Circulation 65:384\u2013398. doi: 10.1111\/j.1542-474X.1999.tb00372.x","journal-title":"Circulation"},{"key":"640_CR44","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1161\/CIRCULATIONAHA.108.840827","volume":"121","author":"FI Marcus","year":"2010","unstructured":"Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MGPJ, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DMY, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W (2010) Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the task force criteria. Circulation 121:1533\u20131541. doi: 10.1161\/CIRCULATIONAHA.108.840827","journal-title":"Circulation"},{"key":"640_CR45","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1016\/j.jacc.2015.09.035","volume":"66","author":"BJ Maron","year":"2015","unstructured":"Maron BJ, Udelson JE, Bonow RO, Nishimura RA, Ackerman MJ, Estes NAM, Cooper LT, Link MS, Maron MS (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 3: hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and other cardiomyopathies, and myocarditis. J Am Coll Cardiol 66:2362\u20132371. doi: 10.1016\/j.jacc.2015.09.035","journal-title":"J Am Coll Cardiol"},{"key":"640_CR46","doi-asserted-by":"publisher","first-page":"H174","DOI":"10.1152\/ajpheart.00295.2015","volume":"310","author":"R Martherus","year":"2016","unstructured":"Martherus R, Jain R, Takagi K, Mendsaikhan U, Turdi S, Osinska H, James JF, Kramer K, Purevjav E, Towbin JA (2016) Accelerated cardiac remodeling in desmoplakin transgenic mice in response to endurance exercise is associated with perturbed Wnt\/\u03b2-catenin signaling. Am J Physiol Heart Circ Physiol 310:H174\u2013H187. doi: 10.1152\/ajpheart.00295.2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"640_CR47","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ydbio.2008.11.036","volume":"327","author":"ED Martin","year":"2009","unstructured":"Martin ED, Moriarty MA, Byrnes L, Grealy M (2009) Plakoglobin has both structural and signalling roles in zebrafish development. Dev Biol 327:83\u201396. doi: 10.1016\/j.ydbio.2008.11.036","journal-title":"Dev Biol"},{"key":"640_CR48","doi-asserted-by":"publisher","first-page":"20900","DOI":"10.1073\/pnas.0808315106","volume":"105","author":"T Matsuda","year":"2008","unstructured":"Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto K, Takagi H, Tamamori-Adachi M, Kitajima S, Sadoshima J (2008) Distinct roles of GSK-3 and GSK-3 phosphorylation in the heart under pressure overload. Proc Natl Acad Sci 105:20900\u201320905. doi: 10.1073\/pnas.0808315106","journal-title":"Proc Natl Acad Sci"},{"key":"640_CR49","doi-asserted-by":"crossref","unstructured":"Mazurek SR, Calway T, Harmon C, Farrell P, Kim GH (2016) MicroRNA-130a regulation of desmocollin 2 in a novel model of arrhythmogenic cardiomyopathy. MicroRNA (Shariqah, United Arab Emirates)","DOI":"10.2174\/2211536605666161109111031"},{"key":"640_CR50","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1016\/S0140-6736(00)02379-5","volume":"355","author":"G McKoy","year":"2000","unstructured":"McKoy G, Protonotarios N, Crosby A, Tsatsopoulou A, Anastasakis A, Coonar A, Norman M, Baboonian C, Jeffery S, McKenna WJ (2000) Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease). Lancet 355:2119\u20132124. doi: 10.1016\/S0140-6736(00)02379-5","journal-title":"Lancet"},{"key":"640_CR51","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00439-006-0193-2","volume":"120","author":"KM Meurs","year":"2006","unstructured":"Meurs KM, Lacombe VA, Dryburgh K, Fox PR, Reiser PRPR, Kittleson MD (2006) Differential expression of the cardiac ryanodine receptor in normal and arrhythmogenic right ventricular cardiomyopathy canine hearts. Hum Genet 120:111\u2013118. doi: 10.1007\/s00439-006-0193-2","journal-title":"Hum Genet"},{"key":"640_CR52","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00439-010-0855-y","volume":"128","author":"KM Meurs","year":"2010","unstructured":"Meurs KM, Mauceli E, Lahmers S, Acland GM, White SN, Lindblad-Toh K (2010) Genome-wide association identifies a deletion in the 3\u2032 untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy. Hum Genet 128:315\u2013324. doi: 10.1007\/s00439-010-0855-y","journal-title":"Hum Genet"},{"key":"640_CR53","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s10557-010-6234-z","volume":"24","author":"T Miura","year":"2010","unstructured":"Miura T, Tanno M (2010) Mitochondria and GSK-3\u03b2 in cardioprotection against ischemia\/reperfusion injury. Cardiovasc Drugs Ther 24:255\u2013263. doi: 10.1007\/s10557-010-6234-z","journal-title":"Cardiovasc Drugs Ther"},{"key":"640_CR54","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1387\/ijdb.113390mm","volume":"56","author":"MA Moriarty","year":"2012","unstructured":"Moriarty MA, Ryan R, Lalor P, Dockery P, Byrnes L, Grealy M (2012) Loss of plakophilin 2 disrupts heart development in zebrafish. Int J Dev Biol 56:711\u2013718. doi: 10.1387\/ijdb.113390mm","journal-title":"Int J Dev Biol"},{"key":"640_CR55","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0022-2836(83)90116-X","volume":"163","author":"H Mueller","year":"1983","unstructured":"Mueller H, Franke WW (1983) Biochemical and immunological characterization of desmoplakins I and II, the major polypeptides of the desmosomal plaque. J Mol Biol 163:647\u2013671","journal-title":"J Mol Biol"},{"key":"640_CR56","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1016\/S0735-1097(00)00997-9","volume":"36","author":"A Nava","year":"2000","unstructured":"Nava A, Bauce B, Basso C, Muriago M, Rampazzo A, Villanova C, Daliento L, Buja G, Corrado D, Danieli GA, Thiene G (2000) Clinical profile and long-term follow-up of 37 families with arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol 36:2226\u20132233. doi: 10.1016\/S0735-1097(00)00997-9","journal-title":"J Am Coll Cardiol"},{"key":"640_CR57","doi-asserted-by":"publisher","first-page":"E973","DOI":"10.1073\/pnas.1408111112","volume":"112","author":"M Notari","year":"2015","unstructured":"Notari M, Hu Y, Sutendra G, Dedei\u0107 Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJP, Kelsell DP, de Noronha S, Sheppard MN, Hollinshead M, Mohun TJ, Lu X (2015) iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proc Natl Acad Sci 112:E973\u2013E981. doi: 10.1073\/pnas.1408111112","journal-title":"Proc Natl Acad Sci"},{"key":"640_CR58","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.joa.2016.01.006","volume":"32","author":"S Ohno","year":"2016","unstructured":"Ohno S (2016) The genetic background of arrhythmogenic right ventricular cardiomyopathy. J Arrhythmia 32:398\u2013403. doi: 10.1016\/j.joa.2016.01.006","journal-title":"J Arrhythmia"},{"key":"640_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jvc.2008.04.003","volume":"10","author":"MA Oyama","year":"2008","unstructured":"Oyama MA, Reiken S, Lehnart SE, Chittur SV, Meurs KM, Stern J, Marks AR (2008) Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency. J Vet Cardiol 10:1\u201310. doi: 10.1016\/j.jvc.2008.04.003","journal-title":"J Vet Cardiol"},{"key":"640_CR60","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1084\/jem.20090641","volume":"206","author":"K Pilichou","year":"2009","unstructured":"Pilichou K, Remme CA, Basso C, Campian ME, Rizzo S, Barnett P, Scicluna BP, Bauce B, van den Hoff MJB, de Bakker JMT, Tan HL, Valente M, Nava A, Wilde AAM, Moorman AFM, Thiene G, Bezzina CR (2009) Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy. J Exp Med 206:1787\u20131802. doi: 10.1084\/jem.20090641","journal-title":"J Exp Med"},{"key":"640_CR61","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13023-016-0407-1","volume":"11","author":"K Pilichou","year":"2016","unstructured":"Pilichou K, Thiene G, Bauce B, Rigato I, Lazzarini E, Migliore F, Perazzolo Marra M, Rizzo S, Zorzi A, Daliento L, Corrado D, Basso C (2016) Arrhythmogenic cardiomyopathy. Orphanet J Rare Dis 11:33. doi: 10.1186\/s13023-016-0407-1","journal-title":"Orphanet J Rare Dis"},{"key":"640_CR62","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1093\/eurheartj\/ehv727","volume":"37","author":"YM Pinto","year":"2016","unstructured":"Pinto YM, Elliott PM, Arbustini E, Adler Y, Anastasakis A, B\u00f6hm M, Duboc D, Gimeno J, de Groote P, Imazio M, Heymans S, Klingel K, Komajda M, Limongelli G, Linhart A, Mogensen J, Moon J, Pieper PG, Seferovic PM, Schueler S, Zamorano JL, Caforio ALP, Charron P (2016) Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases. Eur Heart J 37:1850\u20131858. doi: 10.1093\/eurheartj\/ehv727","journal-title":"Eur Heart J"},{"key":"640_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ejhg.2013.124","volume":"22","author":"WP Rijdt te","year":"2014","unstructured":"te Rijdt WP, Jongbloed JD, de Boer RA, Thiene G, Basso C, van den Berg MP, van Tintelen JP (2014) Clinical utility gene card for: arrhythmogenic right ventricular cardiomyopathy (ARVC). Eur J Hum Genet 22:1\u20134. doi: 10.1038\/ejhg.2013.124","journal-title":"Eur J Hum Genet"},{"key":"640_CR64","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/cvr\/cvs219","volume":"95","author":"S Rizzo","year":"2012","unstructured":"Rizzo S, Lodder EM, Verkerk AO, Wolswinkel R, Beekman L, Pilichou K, Basso C, Remme CA, Thiene G, Bezzina CR (2012) Intercalated disc abnormalities, reduced Na+ current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes. Cardiovasc Res 95:409\u2013418. doi: 10.1093\/cvr\/cvs219","journal-title":"Cardiovasc Res"},{"key":"640_CR65","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1016\/j.hrthm.2014.07.020","volume":"11","author":"N Roux-Buisson","year":"2014","unstructured":"Roux-Buisson N, Gandjbakhch E, Donal E, Probst V, Deharo J-C, Chevalier P, Klug D, Mansencal N, Delacretaz E, Cosnay P, Scanu P, Extramiana F, Keller D, Hidden-Lucet F, Trapani J, Fouret P, Frank R, Fressart V, Faur\u00e9 J, Lunardi J, Charron P (2014) Prevalence and significance of rare RYR2 variants in arrhythmogenic right ventricular cardiomyopathy\/dysplasia: results of a systematic screening. Hear Rhythm 11:1999\u20132009. doi: 10.1016\/j.hrthm.2014.07.020","journal-title":"Hear Rhythm"},{"key":"640_CR66","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1083\/jcb.135.1.215","volume":"135","author":"P Ruiz","year":"1996","unstructured":"Ruiz P, Brinkmann V, Ledermann B, Behrend M, Grund C, Thalhammer C, Vogel F, Birchmeier C, G\u00fcnthert U, Franke WW, Birchmeier W (1996) Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol 135:215\u2013225. doi: 10.1083\/jcb.135.1.215","journal-title":"J Cell Biol"},{"key":"640_CR67","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1093\/eurheartj\/ehv110","volume":"36","author":"A-C Ruwald","year":"2015","unstructured":"Ruwald A-C, Marcus F, Estes NAM, Link M, McNitt S, Polonsky B, Calkins H, Towbin JA, Moss AJ, Zareba W (2015) Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J 36:1735\u20131743. doi: 10.1093\/eurheartj\/ehv110","journal-title":"Eur Heart J"},{"key":"640_CR68","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1161\/CIRCEP.113.000392","volume":"6","author":"AFL Schinkel","year":"2013","unstructured":"Schinkel AFL (2013) Implantable cardioverter defibrillators in arrhythmogenic right ventricular dysplasia\/cardiomyopathy: patient outcomes, incidence of appropriate and inappropriate interventions, and complications. Circ Arrhythmia Electrophysiol 6:562\u2013568. doi: 10.1161\/CIRCEP.113.000392","journal-title":"Circ Arrhythmia Electrophysiol"},{"key":"640_CR69","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1016\/j.jacc.2008.09.019","volume":"52","author":"S Sen-Chowdhry","year":"2008","unstructured":"Sen-Chowdhry S, Syrris P, Prasad SK, Hughes SE, Merrifield R, Ward D, Pennell DJ, McKenna WJ (2008) Left-dominant arrhythmogenic cardiomyopathy. J Am Coll Cardiol 52:2175\u20132187. doi: 10.1016\/j.jacc.2008.09.019","journal-title":"J Am Coll Cardiol"},{"key":"640_CR70","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1365-2052.2008.01796.x","volume":"40","author":"MA Simpson","year":"2009","unstructured":"Simpson MA, Cook RW, Solanki P, Patton MA, Dennis JA, Crosby AH (2009) A mutation in NF\u03baB interacting protein 1 causes cardiomyopathy and woolly haircoat syndrome of Poll Hereford cattle. Anim Genet 40:42\u201346. doi: 10.1111\/j.1365-2052.2008.01796.x","journal-title":"Anim Genet"},{"key":"640_CR71","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1056\/NEJM198801213180301","volume":"318","author":"G Thiene","year":"1988","unstructured":"Thiene G, Nava A, Corrado D, Rossi L, Pennelli N (1988) Right ventricular cardiomyopathy and sudden death in young people. N Engl J Med 318:129\u2013133. doi: 10.1056\/NEJM198801213180301","journal-title":"N Engl J Med"},{"key":"640_CR72","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1161\/CIRCULATIONAHA.105.609719","volume":"113","author":"JP Tintelen van","year":"2006","unstructured":"van Tintelen JP (2006) Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia\/cardiomyopathy. Circulation 113:1650\u20131658. doi: 10.1161\/CIRCULATIONAHA.105.609719","journal-title":"Circulation"},{"key":"640_CR73","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/hmg\/10.3.189","volume":"10","author":"N Tiso","year":"2001","unstructured":"Tiso N, Stephan DA, Nava A, Bagattin A, Devaney JM, Stanchi F, Larderet G, Brahmbhatt B, Brown K, Bauce B, Muriago M, Basso C, Thiene G, Danieli G, Rampazzo A (2001) Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Hum Mol Genet 10:189\u2013194. doi: 10.1093\/hmg\/10.3.189","journal-title":"Hum Mol Genet"},{"key":"640_CR74","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1161\/CIRCRESAHA.109.211482","volume":"106","author":"KC Woulfe","year":"2010","unstructured":"Woulfe KC, Gao E, Lal H, Harris D, Fan Q, Vagnozzi R, DeCaul M, Shang X, Patel S, Woodgett JR, Force T, Zhou J (2010) Glycogen synthase kinase-3 regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo. Circ Res 106:1635\u20131645. doi: 10.1161\/CIRCRESAHA.109.211482","journal-title":"Circ Res"},{"key":"640_CR75","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1161\/01.RES.0000241482.19382.c6","volume":"99","author":"Z Yang","year":"2006","unstructured":"Yang Z (2006) Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia\/cardiomyopathy. Circ Res 99:646\u2013655. doi: 10.1161\/01.RES.0000241482.19382.c6","journal-title":"Circ Res"},{"key":"640_CR76","doi-asserted-by":"publisher","first-page":"28101","DOI":"10.1038\/srep28101","volume":"6","author":"H Zhang","year":"2016","unstructured":"Zhang H, Liu S, Dong T, Yang J, Xie Y, Wu Y, Kang K, Hu S, Gou D, Wei Y (2016) Profiling of differentially expressed microRNAs in arrhythmogenic right ventricular cardiomyopathy. Sci Rep 6:28101. doi: 10.1038\/srep28101","journal-title":"Sci Rep"},{"key":"640_CR77","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1172\/JCI80335","volume":"125","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Stroud MJ, Zhang J, Fang X, Ouyang K, Kimura K, Mu Y, Dalton ND, Gu Y, Bradford WH, Peterson KL, Cheng H, Zhou X, Chen J (2015) Normalization of Naxos plakoglobin levels restores cardiac function in mice. J Clin Investig 125:1708\u20131712. doi: 10.1172\/JCI80335","journal-title":"J Clin Investig"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00395-017-0640-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-017-0640-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-017-0640-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:08:16Z","timestamp":1692871696000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00395-017-0640-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,7]]},"references-count":77,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["640"],"URL":"https:\/\/doi.org\/10.1007\/s00395-017-0640-3","relation":{},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,7]]},"article-number":"50"}}