{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:15:59Z","timestamp":1768745759916,"version":"3.49.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NR013396"],"award-info":[{"award-number":["R01 NR013396"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 HL077113"],"award-info":[{"award-number":["P50 HL077113"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-HL07081-38"],"award-info":[{"award-number":["T32-HL07081-38"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000448"],"award-info":[{"award-number":["UL1TR000448"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DA025888"],"award-info":[{"award-number":["R01 DA025888"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DA036583"],"award-info":[{"award-number":["R01 DA036583"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s00395-018-0697-7","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T12:18:56Z","timestamp":1533903536000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction"],"prefix":"10.1007","volume":"113","author":[{"given":"Edward D.","family":"Coverstone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard G.","family":"Bach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LiShiun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura J.","family":"Bierut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allie Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra A.","family":"Lenzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi C.","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen C.","family":"Sucharov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry A.","family":"Stitzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel D.","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5417-1054","authenticated-orcid":false,"given":"Sharon","family":"Cresci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,10]]},"reference":[{"key":"697_CR1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.atherosclerosis.2012.05.029","volume":"223","author":"MG Andreassi","year":"2012","unstructured":"Andreassi MG, Adlerstein D, Carpeggiani C, Shehi E, Fantinato S, Ghezzi E, Botto N, Coceani M, L\u2019Abbate A (2012) Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease. Atherosclerosis 223:409\u2013415. \n                    https:\/\/doi.org\/10.1016\/j.atherosclerosis.2012.05.029","journal-title":"Atherosclerosis"},{"key":"697_CR2","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1161\/CIRCOUTCOMES.110.960468","volume":"4","author":"SV Arnold","year":"2011","unstructured":"Arnold SV, Chan PS, Jones PG, Decker C, Buchanan DM, Krumholz HM, Ho PM, Spertus JA, Consortium COR (2011) Translational research investigating underlying disparities in acute myocardial infarction patients\u2019 health status (TRIUMPH) design and rationale of a prospective multicenter registry. Circ-Cardiovasc Qual 4:467\u2013476. \n                    https:\/\/doi.org\/10.1161\/Circoutcomes.110.960468","journal-title":"Circ-Cardiovasc Qual"},{"key":"697_CR3","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.bcp.2015.04.013","volume":"97","author":"D Bagdas","year":"2015","unstructured":"Bagdas D, AlSharari SD, Freitas K, Tracy M, Damaj MI (2015) The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain. Biochem Pharmacol 97:590\u2013600. \n                    https:\/\/doi.org\/10.1016\/j.bcp.2015.04.013","journal-title":"Biochem Pharmacol"},{"key":"697_CR4","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1176\/appi.ajp.2008.07111711","volume":"165","author":"LJ Bierut","year":"2008","unstructured":"Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, Xuei XL, Saccone NL, Saccone SF, Bertelsen S, Fox L, Horton WJ, Breslau N, Budde J, Cloninger CR, Dick DM, Foroud T, Hatsukami D, Hesselbrock V, Johnson EO, Kramer J, Kuperman S, Madden PAF, Mayo K, Nurnberger J, Pomerleau O, Porjesz B, Reyes O, Schuckit M, Swan G, Tischfield JA, Edenberg HJ, Rice JP, Goate AM (2008) Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry 165:1163\u20131171. \n                    https:\/\/doi.org\/10.1176\/appi.ajp.2008.07111711","journal-title":"Am J Psychiatry"},{"key":"697_CR5","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature05911","volume":"447","author":"PR Burton","year":"2007","unstructured":"Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, Evans D, Leung HT, Marchini JL, Morris AP, Spencer CCA, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, Nutland S, Prowse CV, Stevens HE, Taylor NC, Walters GR, Walker NM, Watkins NA, Winzer T, Jones RW, McArdle WL, Ring SM, Strachan DP, Pembrey M, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskvina V, Nikolov I, O\u2019Donovan MC, Owen MJ, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN, Ball SG, Balmforth AJ, Barrett JH, Bishop DT, Iles MM, Maqbool A, Yuldasheva N, Hall AS, Braund PS, Dixon RJ, Mangino M, Stevens S, Thompson JR, Bredin F, Tremelling M, Parkes M, Drummond H, Lees CW, Nimmo ER, Satsangi J, Fisher SA, Forbes A, Lewis CM, Onnie CM, Prescott NJ, Sanderson J, Mathew CG, Barbour J, Mohiuddin MK, Todhunter CE, Mansfield JC, Ahmad T, Cummings FR, Jewell DP et al (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661\u2013678. \n                    https:\/\/doi.org\/10.1038\/nature05911","journal-title":"Nature"},{"key":"697_CR6","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1097\/FJC.0b013e31822b7204","volume":"58","author":"L Calvillo","year":"2011","unstructured":"Calvillo L, Vanoli E, Andreoli E, Besana A, Omodeo E, Gnecchi M, Zerbi P, Vago G, Busca G, Schwartz PJ (2011) Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion. J Cardiovasc Pharmacol 58:500\u2013507. \n                    https:\/\/doi.org\/10.1097\/FJC.0b013e31822b7204","journal-title":"J Cardiovasc Pharmacol"},{"key":"697_CR7","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1093\/ntr\/ntu059","volume":"16","author":"LS Chen","year":"2014","unstructured":"Chen LS, Bach RG, Lenzini PA, Spertus JA, Bierut LJ, Cresci S (2014) CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction. Nicotine Tob Res 16:1224\u20131231. \n                    https:\/\/doi.org\/10.1093\/ntr\/ntu059","journal-title":"Nicotine Tob Res"},{"key":"697_CR8","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1176\/appi.ajp.2012.11101545","volume":"169","author":"LS Chen","year":"2012","unstructured":"Chen LS, Baker TB, Piper ME, Breslau N, Cannon DS, Doheny KF, Gogarten SM, Johnson E, Saccone NL, Wang JC, Weiss RB, Goate AM, Bierut LJ (2012) Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and Cessation treatments in smoking cessation success. Am J Psychiatry 169:735\u2013742. \n                    https:\/\/doi.org\/10.1176\/appi.ajp.2012.11101545","journal-title":"Am J Psychiatry"},{"key":"697_CR9","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.jacc.2012.02.051","volume":"60","author":"S Cresci","year":"2012","unstructured":"Cresci S, Dorn GW, Jones PG, Beitelshees AL, Li AY, Lenzini PA, Province MA, Spertus JA, Lanfear DE (2012) Adrenergic-pathway gene variants influence beta-blocker-related outcomes after acute coronary syndrome in a race-specific manner. J Am Coll Cardiol 60:898\u2013907. \n                    https:\/\/doi.org\/10.1016\/j.jacc.2012.02.051","journal-title":"J Am Coll Cardiol"},{"key":"697_CR10","doi-asserted-by":"publisher","first-page":"1426-U1173","DOI":"10.1161\/CIRCULATIONAHA.111.029173","volume":"124","author":"S Cresci","year":"2011","unstructured":"Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye RL, Bach RG, Grp BDS (2011) Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial. Circulation 124:1426-U1173. \n                    https:\/\/doi.org\/10.1161\/Circulationaha.111.029173","journal-title":"Circulation"},{"key":"697_CR11","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.it.2011.05.004","volume":"32","author":"D Nardo De","year":"2011","unstructured":"De Nardo D, Latz E (2011) NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol 32:373\u2013379. \n                    https:\/\/doi.org\/10.1016\/j.it.2011.05.004","journal-title":"Trends Immunol"},{"key":"697_CR12","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/tpj.2014.28","volume":"15","author":"JP Depta","year":"2015","unstructured":"Depta JP, Lenzini PA, Lanfear DE, Wang TY, Spertus JA, Bach RG, Cresci S (2015) Clinical outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups following acute myocardial infarction. Pharmacogenom J 15:20\u201325. \n                    https:\/\/doi.org\/10.1038\/tpj.2014.28","journal-title":"Pharmacogenom J"},{"key":"697_CR13","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1161\/CIRCGENETICS.109.917443","volume":"3","author":"KL Ellis","year":"2010","unstructured":"Ellis KL, Pilbrow AP, Frampton CM, Doughty RN, Whalley GA, Ellis CJ, Palmer BR, Skelton L, Yandle TG, Palmer SC, Troughton RW, Richards AM, Cameron VA (2010) A common variant at chromosome 9P21.3 is associated with age of onset of coronary disease but not subsequent mortality. CircCardiovascGenet 3:286\u2013293. \n                    https:\/\/doi.org\/10.1161\/CIRCGENETICS.109.917443","journal-title":"CircCardiovascGenet"},{"key":"697_CR14","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1161\/CIRCULATIONAHA.108.792986","volume":"118","author":"DS Frankel","year":"2008","unstructured":"Frankel DS, Meigs JB, Massaro JM, Wilson PWF, O\u2019Donnell CJ, D\u2019Agostino RB, Tofler GH (2008) Von Willebrand factor, type 2 diabetes mellitus, and risk of cardiovascular disease the framingham offspring study. Circulation 118:2533\u20132539. \n                    https:\/\/doi.org\/10.1161\/Circulationaha.108.792986","journal-title":"Circulation"},{"key":"697_CR15","first-page":"1","volume":"62","author":"M Heron","year":"2013","unstructured":"Heron M (2013) Deaths: leading causes for 2010. NatlVital StatRep 62:1\u201397","journal-title":"NatlVital StatRep"},{"key":"697_CR16","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1093\/eurheartj\/ehw224","volume":"38","author":"G Heusch","year":"2017","unstructured":"Heusch G, Gersh BJ (2017) The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. Eur Heart J 38:774\u2013784. \n                    https:\/\/doi.org\/10.1093\/eurheartj\/ehw224","journal-title":"Eur Heart J"},{"key":"697_CR17","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.jcin.2009.08.021","volume":"2","author":"P Hoppmann","year":"2009","unstructured":"Hoppmann P, Erl A, Turk S, Tiroch K, Mehilli J, Schomig A, Kastrati A, Koch W (2009) No association of chromosome 9p21.3 variation with clinical and angiographic outcomes after placement of drug-eluting stents. Jacc-Cardiovasc Interv 2:1149\u20131155. \n                    https:\/\/doi.org\/10.1016\/j.jcin.2009.08.021","journal-title":"Jacc-Cardiovasc Interv"},{"key":"697_CR18","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1161\/CIRCULATIONAHA.110.982777","volume":"123","author":"M Kawaguchi","year":"2011","unstructured":"Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U (2011) Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia\/reperfusion injury. Circulation 123:594\u2013604. \n                    https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.982777","journal-title":"Circulation"},{"key":"697_CR19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/gm255","volume":"3","author":"DE Lanfear","year":"2011","unstructured":"Lanfear DE, Jones PG, Cresci S, Tang FM, Rathore SS, Spertus JA (2011) Factors influencing patient willingness to participate in genetic research after a myocardial infarction. Genome Med 3:39. \n                    https:\/\/doi.org\/10.1186\/gm255","journal-title":"Genome Med"},{"key":"697_CR20","doi-asserted-by":"publisher","first-page":"950","DOI":"10.5114\/aoms.2016.61356","volume":"12","author":"WL Li","year":"2016","unstructured":"Li WL, Hua LG, Qu P, Yan WH, Ming C, Jun YD, Yuan LD, Nan N (2016) NLRP3 inflammasome: a novel link between lipoproteins and atherosclerosis. Arch Med Sci 12:950\u2013958. \n                    https:\/\/doi.org\/10.5114\/aoms.2016.61356","journal-title":"Arch Med Sci"},{"key":"697_CR21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408. \n                    https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"697_CR22","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1097\/FJC.0000000000000053","volume":"63","author":"C Marchetti","year":"2014","unstructured":"Marchetti C, Chojnacki J, Toldo S, Mezzaroma E, Tranchida N, Rose SW, Federici M, Van Tassell BW, Zhang S, Abbate A (2014) A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J Cardiovasc Pharmacol 63:316\u2013322. \n                    https:\/\/doi.org\/10.1097\/FJC.0000000000000053","journal-title":"J Cardiovasc Pharmacol"},{"key":"697_CR23","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.jacc.2016.05.049","volume":"68","author":"RL McNamara","year":"2016","unstructured":"McNamara RL, Kennedy KF, Cohen DJ, Diercks DB, Moscucci M, Ramee S, Wang TY, Connolly T, Spertus JA (2016) Predicting in-hospital mortality in patients with acute myocardial infarction. J Am Coll Cardiol 68:626\u2013635. \n                    https:\/\/doi.org\/10.1016\/j.jacc.2016.05.049","journal-title":"J Am Coll Cardiol"},{"key":"697_CR24","doi-asserted-by":"publisher","first-page":"19725","DOI":"10.1073\/pnas.1108586108","volume":"108","author":"E Mezzaroma","year":"2011","unstructured":"Mezzaroma E, Toldo S, Farkas D, Seropian IM, Van Tassell BW, Salloum FN, Kannan HR, Menna AC, Voelkel NF, Abbate A (2011) The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc Natl Acad Sci USA 108:19725\u201319730. \n                    https:\/\/doi.org\/10.1073\/pnas.1108586108","journal-title":"Proc Natl Acad Sci USA"},{"key":"697_CR25","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/1471-2350-12-127","volume":"12","author":"TM Morgan","year":"2011","unstructured":"Morgan TM, House JA, Cresci S, Jones P, Allayee H, Hazen SL, Patel Y, Patel RS, Eapen DJ, Waddy SP, Quyyumi AA, Kleber ME, Marz W, Winkelmann BR, Boehm BO, Krumholz HM, Spertus JA (2011) Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome. BMC Med Genet 12:127. \n                    https:\/\/doi.org\/10.1186\/1471-2350-12-127","journal-title":"BMC Med Genet"},{"key":"697_CR26","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.amjcard.2005.03.039","volume":"96","author":"AJ Moss","year":"2005","unstructured":"Moss AJ, Ryan D, Oakes D, Goldstein RE, Greenberg H, Bodenheimer MM, Brown MW, Case RB, Dwyer EM, Eberly SW, Francis CW, Gillespie JA, Krone RJ, Lichstein E, MacCluer JW, Marcus FI, McCarthy J, Sparks CW, Zareba W (2005) Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction. Am J Cardiol 96:177\u2013182. \n                    https:\/\/doi.org\/10.1016\/j.amjcard.2005.03.039","journal-title":"Am J Cardiol"},{"key":"697_CR27","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1084\/jem.20070885","volume":"204","author":"M Nahrendorf","year":"2007","unstructured":"Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ (2007) The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 204:3037\u20133047. \n                    https:\/\/doi.org\/10.1084\/jem.20070885","journal-title":"J Exp Med"},{"key":"697_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00395-017-0601-x","volume":"112","author":"JM Pickard","year":"2017","unstructured":"Pickard JM, Burke N, Davidson SM, Yellon DM (2017) Intrinsic cardiac ganglia and acetylcholine are important in the mechanism of ischaemic preconditioning. Basic Res Cardiol 112:11. \n                    https:\/\/doi.org\/10.1007\/s00395-017-0601-x","journal-title":"Basic Res Cardiol"},{"key":"697_CR29","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s00395-016-0568-z","volume":"111","author":"JM Pickard","year":"2016","unstructured":"Pickard JM, Davidson SM, Hausenloy DJ, Yellon DM (2016) Co-dependence of the neural and humoral pathways in the mechanism of remote ischemic conditioning. Basic Res Cardiol 111:50. \n                    https:\/\/doi.org\/10.1007\/s00395-016-0568-z","journal-title":"Basic Res Cardiol"},{"key":"697_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001053","author":"NL Saccone","year":"2010","unstructured":"Saccone NL, Culverhouse RC, Schwantes-An TH, Cannon DS, Chen XN, Cichon S, Giegling I, Han SZ, Han YH, Keskitalo-Vuokko K, Kong XY, Landi MT, Ma JZ, Short SE, Stephens SH, Stevens VL, Sun LW, Wang YF, Wenzlaff AS, Aggen SH, Breslau N, Broderick P, Chatterjee N, Chen JC, Heath AC, Heliovaara M, Hoft NR, Hunter DJ, Jensen MK, Martin NG, Montgomery GW, Niu TH, Payne TJ, Peltonen L, Pergadia ML, Rice JP, Sherva R, Spitz MR, Sun JZ, Wang JC, Weiss RB, Wheeler W, Witt SH, Yang BZ, Caporaso NE, Ehringer MA, Eisen T, Gapstur SM, Gelernter J, Houlston R, Kaprio J, Kendler KS, Kraft P, Leppert MF, Li MD, Madden PAF, Nothen MM, Pillai S, Rietschel M, Rujescu D, Schwartz A, Amos CI, Bierut LJ (2010) Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet. \n                    https:\/\/doi.org\/10.1371\/journal.pgen.1001053","journal-title":"PLoS Genet"},{"key":"697_CR31","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1086\/502802","volume":"78","author":"P Scheet","year":"2006","unstructured":"Scheet P, Stephens M (2006) A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase. Am J Hum Genet 78:629\u2013644. \n                    https:\/\/doi.org\/10.1086\/502802","journal-title":"Am J Hum Genet"},{"key":"697_CR32","volume-title":"Statistical analysis of epidemiologic data","author":"S Selvin","year":"1991","unstructured":"Selvin S (1991) Statistical analysis of epidemiologic data. Oxford University Press, New York"},{"key":"697_CR33","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1359\/jbmr.2000.15.8.1477","volume":"15","author":"S Takeshita","year":"2000","unstructured":"Takeshita S, Kaji K, Kudo A (2000) Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J Bone Miner Res 15:1477\u20131488. \n                    https:\/\/doi.org\/10.1359\/jbmr.2000.15.8.1477","journal-title":"J Bone Miner Res"},{"key":"697_CR34","doi-asserted-by":"publisher","first-page":"638-U639","DOI":"10.1038\/nature06846","volume":"452","author":"TE Thorgeirsson","year":"2008","unstructured":"Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson KP, Manolescu A, Thorleifsson G, Stefansson H, Ingason A, Stacey SN, Bergthorsson JT, Thorlacius S, Gudmundsson J, Jonsson T, Jakobsdottir M, Saemundsdottir J, Olafsdottir O, Gudmundsson LJ, Bjornsdottir G, Kristjansson K, Skuladottir H, Isaksson HJ, Gudbjartsson T, Jones GT, Mueller T, Gottsater A, Flex A, Aben KKH, de Vegt F, Mulders PFA, Isla D, Vidal MJ, Asin L, Saez B, Murillo L, Blondal T, Kolbeinsson H, Stefansson JG, Hansdottir I, Runarsdottir V, Pola R, Lindblad B, van Rij AM, Dieplinger B, Haltmayer M, Mayordomo JI, Kiemeney LA, Matthiasson SE, Oskarsson H, Tyrfingsson T, Gudbjartsson DF, Gulcher JR, Jonsson S, Thorsteinsdottir U, Kong A, Stefansson K (2008) A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452:638-U639. \n                    https:\/\/doi.org\/10.1038\/nature06846","journal-title":"Nature"},{"key":"697_CR35","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1089\/ars.2014.5989","volume":"22","author":"S Toldo","year":"2015","unstructured":"Toldo S, Mezzaroma E, Mauro AG, Salloum F, Van Tassell BW, Abbate A (2015) The inflammasome in myocardial injury and cardiac remodeling. Antioxid Redox Signal 22:1146\u20131161. \n                    https:\/\/doi.org\/10.1089\/ars.2014.5989","journal-title":"Antioxid Redox Signal"},{"key":"697_CR36","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1016\/j.jacc.2005.06.064","volume":"46","author":"EJ Topol","year":"2005","unstructured":"Topol EJ (2005) Simon Dack Lecture. The genomic basis of myocardial infarction. J Am Coll Cardiol 46:1456\u20131465. \n                    https:\/\/doi.org\/10.1016\/j.jacc.2005.06.064","journal-title":"J Am Coll Cardiol"},{"key":"697_CR37","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/sj.ejhg.5201238","volume":"12","author":"DA Tregouet","year":"2004","unstructured":"Tregouet DA, Tiret L (2004) Cox proportional hazards survival regression in haplotype-based association analysis using the stochastic-EM algorithm. Eur J Hum Genet 12:971\u2013974. \n                    https:\/\/doi.org\/10.1038\/sj.ejhg.5201238","journal-title":"Eur J Hum Genet"},{"key":"697_CR38","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1074\/mcp.M500279-MCP200","volume":"4","author":"M Uhlen","year":"2005","unstructured":"Uhlen M, Bjorling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergstrom K, Brumer H, Cerjan D, Ekstrom M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Bjorklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Skollermo A, Steen J, Stenvall M, Sterky F, Stromberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Walden A, Wan J, Wernerus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Ponten F (2005) A human protein atlas for normal and cancer tissues based on antibody proteomics. Mol Cell Proteom 4:1920\u20131932. \n                    https:\/\/doi.org\/10.1074\/mcp.M500279-MCP200","journal-title":"Mol Cell Proteom"},{"key":"697_CR39","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1007\/s00395-015-0508-3","volume":"110","author":"A Uitterdijk","year":"2015","unstructured":"Uitterdijk A, Yetgin T, te Lintel Hekkert M, Sneep S, Krabbendam-Peters I, van Beusekom HM, Fischer TM, Cornelussen RN, Manintveld OC, Merkus D, Duncker DJ (2015) Vagal nerve stimulation started just prior to reperfusion limits infarct size and no-reflow. Basic Res Cardiol 110:508. \n                    https:\/\/doi.org\/10.1007\/s00395-015-0508-3","journal-title":"Basic Res Cardiol"},{"key":"697_CR40","doi-asserted-by":"publisher","first-page":"4340","DOI":"10.4049\/jimmunol.1003722","volume":"186","author":"G Vida","year":"2011","unstructured":"Vida G, Pena G, Deitch EA, Ulloa L (2011) Alpha7-cholinergic receptor mediates vagal induction of splenic norepinephrine. J Immunol 186:4340\u20134346. \n                    https:\/\/doi.org\/10.4049\/jimmunol.1003722","journal-title":"J Immunol"},{"key":"697_CR41","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1253\/circj.CJ-11-1166","volume":"76","author":"SS Virani","year":"2012","unstructured":"Virani SS, Brautbar A, Lee VV, MacArthur E, Morrison AC, Grove ML, Nambi V, Frazier L, Wilson JM, Willerson JT, Boerwinkle E, Ballantyne CM (2012) Chromosome 9p21 single nucleotide polymorphisms are not associated with recurrent myocardial infarction in patients with established coronary artery disease. Circ J 76:950\u2013956. \n                    https:\/\/doi.org\/10.1253\/circj.CJ-11-1166","journal-title":"Circ J"},{"key":"697_CR42","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature01339","volume":"421","author":"H Wang","year":"2003","unstructured":"Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Wang H, Yang H, Ulloa L, Al-Abed Y, Czura CJ, Tracey KJ (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421:384\u2013388. \n                    https:\/\/doi.org\/10.1038\/nature01339","journal-title":"Nature"},{"key":"697_CR43","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1093\/hmg\/ddp231","volume":"18","author":"JC Wang","year":"2009","unstructured":"Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu PY, Budde JP, Duan WM, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, Steinbach JH, Stitzel JA, Anderson MW, You M, Stevens VL, Bierut LJ, Goate AM, Collaborators C, Collaborators G (2009) Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Hum Mol Genet 18:3125\u20133135. \n                    https:\/\/doi.org\/10.1093\/hmg\/ddp231","journal-title":"Hum Mol Genet"},{"key":"697_CR44","doi-asserted-by":"publisher","first-page":"688-U247","DOI":"10.1161\/Circresaha.108.188425","volume":"104","author":"L Wang","year":"2009","unstructured":"Wang L, Zheng J, Bai X, Liu B, Liu CJ, Xu QB, Zhu Y, Wang NP, Kong W, Wang X (2009) ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries. Circ Res 104:688-U247. \n                    https:\/\/doi.org\/10.1161\/Circresaha.108.188425","journal-title":"Circ Res"},{"key":"697_CR45","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/eurheartj\/ehs389","volume":"34","author":"E Wauters","year":"2013","unstructured":"Wauters E, Carruthers KF, Buysschaert I, Dunbar DR, Peuteman G, Belmans A, Budaj A, Van de Werf F, Lambrechts D, Fox KAA (2013) Influence of 23 coronary artery disease variants on recurrent myocardial infarction or cardiac death: the GRACE Genetics Study. Eur Heart J 34:993\u20131001. \n                    https:\/\/doi.org\/10.1093\/eurheartj\/ehs389","journal-title":"Eur Heart J"},{"key":"697_CR46","doi-asserted-by":"publisher","first-page":"154936","DOI":"10.1155\/2014\/154936","volume":"2014","author":"K Weber","year":"2014","unstructured":"Weber K, Schilling JD (2014) Distinct lysosome phenotypes influence inflammatory function in peritoneal and bone marrow-derived macrophages. Int J Inflam 2014:154936. \n                    https:\/\/doi.org\/10.1155\/2014\/154936","journal-title":"Int J Inflam"},{"key":"697_CR47","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.amjcard.2005.05.046","volume":"96","author":"AT Yan","year":"2005","unstructured":"Yan AT, Yan RT, Tan M, Eagle KA, Granger CB, Dabbous OH, Fitchett D, Grima E, Langer A, Goodman SG, Acs, (2005) In-hospital revascularization and one-year outcome of acute coronary syndrome patients stratified by the GRACE risk score. Am J Cardiol 96:913\u2013916. \n                    https:\/\/doi.org\/10.1016\/j.amjcard.2005.05.046","journal-title":"Am J Cardiol"},{"key":"697_CR48","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.2337\/db11-1393","volume":"61","author":"J Yang","year":"2012","unstructured":"Yang J, Zhu Y, Cole SA, Haack K, Zhang Y, Beebe LA, Howard BV, Best LG, Devereux RB, Henderson JA, Henderson P, Lee ET, Zhao J (2012) A gene-family analysis of 61 genetic variants in the nicotinic acetylcholine receptor genes for insulin resistance and type 2 diabetes in American Indians. Diabetes 61:1888\u20131894. \n                    https:\/\/doi.org\/10.2337\/db11-1393","journal-title":"Diabetes"},{"key":"697_CR49","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1161\/CIRCGENETICS.112.963967","volume":"6","author":"JY Yang","year":"2013","unstructured":"Yang JY, Zhu Y, Lee ET, Zhang Y, Cole SA, Haack K, Best LG, Devereux RB, Roman MJ, Howard BV, Zhao JY (2013) Joint associations of 61 genetic variants in the nicotinic acetylcholine receptor genes with subclinical atherosclerosis in American Indians a gene-family analysis. Circ-Cardiovasc Gene 6:89\u201396. \n                    https:\/\/doi.org\/10.1161\/Circgenetics.112.963967","journal-title":"Circ-Cardiovasc Gene"},{"key":"697_CR50","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/1465-9921-12-158","volume":"12","author":"J Zhang","year":"2011","unstructured":"Zhang J, Summah H, Zhu YG, Qu JM (2011) Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis. Respir Res 12:158. \n                    https:\/\/doi.org\/10.1186\/1465-9921-12-158","journal-title":"Respir Res"},{"key":"697_CR51","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00395-013-0345-1","volume":"108","author":"M Zhao","year":"2013","unstructured":"Zhao M, He X, Bi XY, Yu XJ, Gil Wier W, Zang WJ (2013) Vagal stimulation triggers peripheral vascular protection through the cholinergic anti-inflammatory pathway in a rat model of myocardial ischemia\/reperfusion. Basic Res Cardiol 108:345. \n                    https:\/\/doi.org\/10.1007\/s00395-013-0345-1","journal-title":"Basic Res Cardiol"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00395-018-0697-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-018-0697-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-018-0697-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T15:38:55Z","timestamp":1569253135000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00395-018-0697-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,10]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["697"],"URL":"https:\/\/doi.org\/10.1007\/s00395-018-0697-7","relation":{},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,10]]},"assertion":[{"value":"6 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Edward Coverstone: None. Richard G. Bach: Research Grants: Novartis, MyoKardia. Consultant (Clinical Event Committee activity only): Novo Nordisk, Pharmacosmos NA. LiShiun Chen: None.\u00a0Laura J. Bierut: Copyrights\/Patents: Listed as an inventor on Issued U.S. Patent 8080,371,\u201cMarkers for Addiction\u201d covering the use of certain SNPs in determining the diagnosis, prognosis, and treatment of addiction. Allie Y.\u00a0Li: None. Petra A. Lenzini: None. Heidi C. O'Neill: None. John A. Spertus: Research Grants: Eli Lilly, EveHeart, Genentech, Gilead. Consultant: St. Jude Medical, United Healthcare, Amgen, Genentech, Janssen. Copyrights\/Patents: Seattle Angina Questionnaire, Kansas City Cardiomyopathy Questionnaire, Peripheral Artery Questionnaire, US Patents: 7643,969; 7,853,456; 12\/965,656; 13\/615,401. Carmen Sucharov: Scientific founder and shareholder, CoramiR Inc. and miRagen Inc. Jerry Stitzel: Research grants: Pfizer. Joel Schilling: None. Sharon Cresci: None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"38"}}