{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:26:53Z","timestamp":1788964013847,"version":"build-2803163510"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100008436","name":"Ernst und Berta Grimmke Stiftung","doi-asserted-by":"publisher","award":["3\/09"],"award-info":[{"award-number":["3\/09"]}],"id":[{"id":"10.13039\/501100008436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009400","name":"Medizinische Fakult\u00e4t, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100009400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL131517"],"award-info":[{"award-number":["R01-HL131517"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL136389"],"award-info":[{"award-number":["R01-HL136389"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL089598"],"award-info":[{"award-number":["R01-HL089598"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL-136389"],"award-info":[{"award-number":["R01-HL-136389"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Do 769\/4-1"],"award-info":[{"award-number":["Do 769\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00395-019-0771-9","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T17:03:14Z","timestamp":1578416594000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart"],"prefix":"10.1007","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3965-6165","authenticated-orcid":false,"given":"Anke C.","family":"Fender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Kleeschulte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Stolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Leineweber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Kamler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dobromir","family":"Dobrev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"key":"771_CR1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ijcard.2018.05.033","volume":"271","author":"P Altieri","year":"2018","unstructured":"Altieri P, Bertolotto M, Fabbi P, Sportelli E, Balbi M, Santini F, Brunelli C, Canepa M, Montecucco F, Ameri P (2018) Thrombin induces protease-activated receptor 1 signaling and activation of human atrial fibroblasts and dabigatran prevents these effects. Int J Cardiol 271:219\u2013227. https:\/\/doi.org\/10.1016\/j.ijcard.2018.05.033","journal-title":"Int J Cardiol"},{"key":"771_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.thromres.2011.07.033","volume":"129","author":"HJ Beijers","year":"2012","unstructured":"Beijers HJ, Ferreira I, Spronk HM, Bravenboer B, Dekker JM, Nijpels G, ten Cate H, Stehouwer CD (2012) Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability: potential role of central adiposity and low-grade inflammation\u2014the Hoorn Study. Thromb Res 129:557\u2013562. https:\/\/doi.org\/10.1016\/j.thromres.2011.07.033","journal-title":"Thromb Res"},{"key":"771_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s10557-017-6732-3","volume":"31","author":"Y Bulani","year":"2017","unstructured":"Bulani Y, Sharma SS (2017) Argatroban attenuates diabetic cardiomyopathy in rats by reducing fibrosis, inflammation, apoptosis, and protease-activated receptor expression. Cardiovasc Drugs Ther 31:255\u2013267. https:\/\/doi.org\/10.1007\/s10557-017-6732-3","journal-title":"Cardiovasc Drugs Ther"},{"key":"771_CR4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11010-018-3394-9","volume":"451","author":"Y Bulani","year":"2019","unstructured":"Bulani Y, Srinivasan K, Sharma SS (2019) Attenuation of type-1 diabetes-induced cardiovascular dysfunctions by direct thrombin inhibitor in rats: a mechanistic study. Mol Cell Biochem 451:69\u201378. https:\/\/doi.org\/10.1007\/s11010-018-3394-9","journal-title":"Mol Cell Biochem"},{"key":"771_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1160\/th14-02-0156","volume":"113","author":"E Campello","year":"2015","unstructured":"Campello E, Zabeo E, Radu CM, Spiezia L, Gavasso S, Fadin M, Woodhams B, Vettor R, Simioni P (2015) Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events. Thromb Haemost 113:85\u201396. https:\/\/doi.org\/10.1160\/th14-02-0156","journal-title":"Thromb Haemost"},{"key":"771_CR6","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1517\/14656566.9.15.2717","volume":"9","author":"DH Carney","year":"2008","unstructured":"Carney DH, Olszewska-Pazdrak B (2008) Could rusalatide acetate be the future drug of choice for diabetic foot ulcers and fracture repair? Expert Opin Pharmacother 9:2717\u20132726. https:\/\/doi.org\/10.1517\/14656566.9.15.2717","journal-title":"Expert Opin Pharmacother"},{"key":"771_CR7","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s11239-015-1327-y","volume":"41","author":"R Chaudhary","year":"2016","unstructured":"Chaudhary R, Bliden KP, Tantry US, Mohammed N, Mathew D, Gesheff MG, Franzese CJ, Gurbel PA (2016) Association of weight gain with coronary artery disease, inflammation and thrombogenicity. J Thromb Thrombolysis 41:394\u2013403. https:\/\/doi.org\/10.1007\/s11239-015-1327-y","journal-title":"J Thromb Thrombolysis"},{"key":"771_CR8","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.3389\/fphys.2018.01115","volume":"9","author":"G Chen","year":"2018","unstructured":"Chen G, Chelu MG, Dobrev D, Li N (2018) Cardiomyocyte inflammasome signaling in cardiomyopathies and atrial fibrillation: mechanisms and potential therapeutic implications. Front Physiol 9:1115. https:\/\/doi.org\/10.3389\/fphys.2018.01115","journal-title":"Front Physiol"},{"key":"771_CR9","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1161\/atvbaha.110.219105","volume":"31","author":"S Dangwal","year":"2011","unstructured":"Dangwal S, Rauch BH, Gensch T, Dai L, Bretschneider E, Vogelaar CF, Schror K, Rosenkranz AC (2011) High glucose enhances thrombin responses via protease-activated receptor-4 in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 31:624\u2013633. https:\/\/doi.org\/10.1161\/atvbaha.110.219105","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"771_CR10","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/jth.13191","volume":"14","author":"GG de Ridder","year":"2016","unstructured":"de Ridder GG, Lundblad RL, Pizzo SV (2016) Actions of thrombin in the interstitium. J Thromb Haemost 14:40\u201347. https:\/\/doi.org\/10.1111\/jth.13191","journal-title":"J Thromb Haemost"},{"key":"771_CR11","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.jdiacomp.2015.12.018","volume":"30","author":"CP Domingueti","year":"2016","unstructured":"Domingueti CP, Dusse LM, Carvalho M, de Sousa LP, Gomes KB, Fernandes AP (2016) Diabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. J Diabetes Complicat 30:738\u2013745. https:\/\/doi.org\/10.1016\/j.jdiacomp.2015.12.018","journal-title":"J Diabetes Complicat"},{"key":"771_CR12","first-page":"1087","volume":"134","author":"TA Drake","year":"1989","unstructured":"Drake TA, Morrissey JH, Edgington TS (1989) Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol 134:1087\u20131097","journal-title":"Am J Pathol"},{"key":"771_CR13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pharmthera.2016.11.013","volume":"172","author":"A Faria","year":"2017","unstructured":"Faria A, Persaud SJ (2017) Cardiac oxidative stress in diabetes: mechanisms and therapeutic potential. Pharmacol Ther 172:50\u201362. https:\/\/doi.org\/10.1016\/j.pharmthera.2016.11.013","journal-title":"Pharmacol Ther"},{"key":"771_CR14","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1160\/th17-03-0219","volume":"117","author":"AC Fender","year":"2017","unstructured":"Fender AC, Rauch BH, Geisler T, Schror K (2017) Protease-activated receptor par-4: an inducible switch between thrombosis and vascular inflammation? Thromb Haemost 117:2013\u20132025. https:\/\/doi.org\/10.1160\/th17-03-0219","journal-title":"Thromb Haemost"},{"key":"771_CR15","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1177\/1074248408321468","volume":"13","author":"TW Fossum","year":"2008","unstructured":"Fossum TW, Olszewska-Pazdrak B, Mertens MM, Makarski LA, Miller MW, Hein TW, Kuo L, Clubb F, Fuller GM, Carney DH (2008) Tp508 (chrysalin) reverses endothelial dysfunction and increases perfusion and myocardial function in hearts with chronic ischemia. J Cardiovasc Pharmacol Ther 13:214\u2013225. https:\/\/doi.org\/10.1177\/1074248408321468","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"771_CR16","doi-asserted-by":"publisher","first-page":"e0165565","DOI":"10.1371\/journal.pone.0165565","volume":"11","author":"SL French","year":"2016","unstructured":"French SL, Paramitha AC, Moon MJ, Dickins RA, Hamilton JR (2016) Humanizing the protease-activated receptor (par) expression profile in mouse platelets by knocking par1 into the par3 locus reveals par1 expression is not tolerated in mouse platelets. PLoS ONE 11:e0165565. https:\/\/doi.org\/10.1371\/journal.pone.0165565","journal-title":"PLoS ONE"},{"key":"771_CR17","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s00431-010-1356-7","volume":"170","author":"P Giordano","year":"2011","unstructured":"Giordano P, Del Vecchio GC, Cecinati V, Delvecchio M, Altomare M, De Palma F, De Mattia D, Cavallo L, Faienza MF (2011) Metabolic, inflammatory, endothelial and haemostatic markers in a group of italian obese children and adolescents. Eur J Pediatr 170:845\u2013850. https:\/\/doi.org\/10.1007\/s00431-010-1356-7","journal-title":"Eur J Pediatr"},{"key":"771_CR18","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s00011-014-0767-8","volume":"63","author":"LF Gomides","year":"2014","unstructured":"Gomides LF, Lima OC, Matos NA, Freitas KM, Francischi JN, Tavares JC, Klein A (2014) Blockade of proteinase-activated receptor 4 inhibits neutrophil recruitment in experimental inflammation in mice. Inflamm Res 63:935\u2013941. https:\/\/doi.org\/10.1007\/s00011-014-0767-8","journal-title":"Inflamm Res"},{"key":"771_CR19","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1038\/s41598-018-36140-6","volume":"9","author":"DJ Gorski","year":"2019","unstructured":"Gorski DJ, Petz A, Reichert C, Twarock S, Grandoch M, Fischer JW (2019) Cardiac fibroblast activation and hyaluronan synthesis in response to hyperglycemia and diet-induced insulin resistance. Sci Rep 9:1827. https:\/\/doi.org\/10.1038\/s41598-018-36140-6","journal-title":"Sci Rep"},{"key":"771_CR20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2147\/jir.S141220","volume":"11","author":"M Groslambert","year":"2018","unstructured":"Groslambert M, Py BF (2018) Spotlight on the nlrp3 inflammasome pathway. J Inflamm Res 11:359\u2013374. https:\/\/doi.org\/10.2147\/jir.S141220","journal-title":"J Inflamm Res"},{"key":"771_CR21","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.4049\/jimmunol.1002720","volume":"186","author":"G Guarda","year":"2011","unstructured":"Guarda G, Zenger M, Yazdi AS, Schroder K, Ferrero I, Menu P, Tardivel A, Mattmann C, Tschopp J (2011) Differential expression of nlrp3 among hematopoietic cells. J Immunol 186:2529\u20132534. https:\/\/doi.org\/10.4049\/jimmunol.1002720","journal-title":"J Immunol"},{"key":"771_CR22","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1161\/atvbaha.117.310550","volume":"38","author":"X Han","year":"2018","unstructured":"Han X, Nieman MT (2018) Par4 (protease-activated receptor 4): particularly important 4 antiplatelet therapy. Arterioscler Thromb Vasc Biol 38:287\u2013289. https:\/\/doi.org\/10.1161\/atvbaha.117.310550","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"771_CR23","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.cardiores.2004.03.026","volume":"63","author":"N Hanna","year":"2004","unstructured":"Hanna N, Cardin S, Leung TK, Nattel S (2004) Differences in atrial versus ventricular remodeling in dogs with ventricular tachypacing-induced congestive heart failure. Cardiovasc Res 63:236\u2013244. https:\/\/doi.org\/10.1016\/j.cardiores.2004.03.026","journal-title":"Cardiovasc Res"},{"key":"771_CR24","doi-asserted-by":"publisher","first-page":"e65817","DOI":"10.1371\/journal.pone.0065817","volume":"8","author":"K Ito","year":"2013","unstructured":"Ito K, Date T, Ikegami M, Hongo K, Fujisaki M, Katoh D, Yoshino T, Anzawa R, Nagoshi T, Yamashita S, Inada K, Matsuo S, Yamane T, Yoshimura M (2013) An immunohistochemical analysis of tissue thrombin expression in the human atria. PLoS ONE 8:e65817. https:\/\/doi.org\/10.1371\/journal.pone.0065817","journal-title":"PLoS ONE"},{"key":"771_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s10753-006-9017-8","volume":"30","author":"S Jesmin","year":"2007","unstructured":"Jesmin S, Gando S, Zaedi S, Sakuraya F (2007) Differential expression, time course and distribution of four pars in rats with endotoxin-induced acute lung injury. Inflammation 30:14\u201327. https:\/\/doi.org\/10.1007\/s10753-006-9017-8","journal-title":"Inflammation"},{"key":"771_CR26","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ijcard.2017.10.019","volume":"252","author":"S Kleeschulte","year":"2018","unstructured":"Kleeschulte S, Jerrentrup J, Gorski D, Schmitt J, Fender AC (2018) Evidence for functional par-4 thrombin receptor expression in cardiac fibroblasts and its regulation by high glucose: par-4 in cardiac fibroblasts. Int J Cardiol 252:163\u2013166. https:\/\/doi.org\/10.1016\/j.ijcard.2017.10.019","journal-title":"Int J Cardiol"},{"key":"771_CR27","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1172\/jci92744","volume":"127","author":"AK Kopec","year":"2017","unstructured":"Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, Weiler H, Owens AP 3rd, Mackman N, Goss A, van Ryn J, Luyendyk JP, Flick MJ (2017) Thrombin promotes diet-induced obesity through fibrin-driven inflammation. J Clin Investig 127:3152\u20133166. https:\/\/doi.org\/10.1172\/jci92744","journal-title":"J Clin Investig"},{"key":"771_CR28","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1124\/jpet.114.218545","volume":"351","author":"AK Kopec","year":"2014","unstructured":"Kopec AK, Joshi N, Towery KL, Kassel KM, Sullivan BP, Flick MJ, Luyendyk JP (2014) Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mice. J Pharmacol Exp Ther 351:288\u2013297. https:\/\/doi.org\/10.1124\/jpet.114.218545","journal-title":"J Pharmacol Exp Ther"},{"key":"771_CR29","doi-asserted-by":"publisher","first-page":"949","DOI":"10.3389\/fphys.2017.00949","volume":"8","author":"J Lagrange","year":"2017","unstructured":"Lagrange J, Didelot M, Mohamadi A, Walton LA, Bloemen S, de Laat B, Louis H, Thornton SN, Derby B, Sherratt MJ, Feve B, Challande P, Akhtar R, Cruickshank JK, Lacolley P, Regnault V (2017) Implication of free fatty acids in thrombin generation and fibrinolysis in vascular inflammation in zucker rats and evolution with aging. Front Physiol 8:949. https:\/\/doi.org\/10.3389\/fphys.2017.00949","journal-title":"Front Physiol"},{"key":"771_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2019.04.110","volume":"514","author":"X Li","year":"2019","unstructured":"Li X, Ke X, Li Z, Li B (2019) Vaspin prevents myocardial injury in rats model of diabetic cardiomyopathy by enhancing autophagy and inhibiting inflammation. Biochem Biophys Res Commun 514:1\u20138. https:\/\/doi.org\/10.1016\/j.bbrc.2019.04.110","journal-title":"Biochem Biophys Res Commun"},{"key":"771_CR31","doi-asserted-by":"publisher","first-page":"915","DOI":"10.5551\/jat.48405","volume":"26","author":"J Liu","year":"2019","unstructured":"Liu J, Nishida M, Inui H, Chang J, Zhu Y, Kanno K, Matsuda H, Sairyo M, Okada T, Nakaoka H, Ohama T, Masuda D, Koseki M, Yamashita S, Sakata Y (2019) Rivaroxaban suppresses the progression of ischemic cardiomyopathy in a murine model of diet-induced myocardial infarction. J Atheroscler Thromb 26:915\u2013930. https:\/\/doi.org\/10.5551\/jat.48405","journal-title":"J Atheroscler Thromb"},{"key":"771_CR32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s10557-013-6498-1","volume":"28","author":"B Luo","year":"2014","unstructured":"Luo B, Li B, Wang W, Liu X, Liu X, Xia Y, Zhang C, Zhang Y, Zhang M, An F (2014) Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting nlrp3 inflammasome and mapk pathways in a type 2 diabetes rat model. Cardiovasc Drugs Ther 28:33\u201343. https:\/\/doi.org\/10.1007\/s10557-013-6498-1","journal-title":"Cardiovasc Drugs Ther"},{"key":"771_CR33","doi-asserted-by":"publisher","first-page":"e104771","DOI":"10.1371\/journal.pone.0104771","volume":"9","author":"B Luo","year":"2014","unstructured":"Luo B, Li B, Wang W, Liu X, Xia Y, Zhang C, Zhang M, Zhang Y, An F (2014) Nlrp3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model. PLoS ONE 9:e104771. https:\/\/doi.org\/10.1371\/journal.pone.0104771","journal-title":"PLoS ONE"},{"key":"771_CR34","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1189\/jlb.3AB1013-567R","volume":"96","author":"S Mahajan-Thakur","year":"2014","unstructured":"Mahajan-Thakur S, Sostmann BD, Fender AC, Behrendt D, Felix SB, Schror K, Rauch BH (2014) Sphingosine-1-phosphate induces thrombin receptor par-4 expression to enhance cell migration and cox-2 formation in human monocytes. J Leukoc Biol 96:611\u2013618. https:\/\/doi.org\/10.1189\/jlb.3AB1013-567R","journal-title":"J Leukoc Biol"},{"key":"771_CR35","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1161\/01.atv.17.11.2430","volume":"17","author":"RD McBane 2nd","year":"1997","unstructured":"McBane RD 2nd, Miller RS, Hassinger NL, Chesebro JH, Nemerson Y, Owen WG (1997) Tissue prothrombin. Universal distribution in smooth muscle. Arterioscler Thromb Vasc Biol 17:2430\u20132436. https:\/\/doi.org\/10.1161\/01.atv.17.11.2430","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"771_CR36","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1124\/mol.115.102723","volume":"89","author":"K Mihara","year":"2016","unstructured":"Mihara K, Ramachandran R, Saifeddine M, Hansen KK, Renaux B, Polley D, Gibson S, Vanderboor C, Hollenberg MD (2016) Thrombin-mediated direct activation of proteinase-activated receptor-2: another target for thrombin signaling. Mol Pharmacol 89:606\u2013614. https:\/\/doi.org\/10.1124\/mol.115.102723","journal-title":"Mol Pharmacol"},{"key":"771_CR37","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1161\/circulationaha.113.007590","volume":"130","author":"G Pavic","year":"2014","unstructured":"Pavic G, Grandoch M, Dangwal S, Jobi K, Rauch BH, Doller A, Oberhuber A, Akhyari P, Schror K, Fischer JW, Fender AC (2014) Thrombin receptor protease-activated receptor 4 is a key regulator of exaggerated intimal thickening in diabetes mellitus. Circulation 130:1700\u20131711. https:\/\/doi.org\/10.1161\/circulationaha.113.007590","journal-title":"Circulation"},{"key":"771_CR38","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.phrs.2018.03.018","volume":"131","author":"LE Pavillard","year":"2018","unstructured":"Pavillard LE, Marin-Aguilar F, Bullon P, Cordero MD (2018) Cardiovascular diseases, nlrp3 inflammasome, and western dietary patterns. Pharmacol Res 131:44\u201350. https:\/\/doi.org\/10.1016\/j.phrs.2018.03.018","journal-title":"Pharmacol Res"},{"key":"771_CR39","doi-asserted-by":"publisher","first-page":"15333","DOI":"10.1073\/pnas.242501899","volume":"99","author":"R Pawlinski","year":"2002","unstructured":"Pawlinski R, Fernandes A, Kehrle B, Pedersen B, Parry G, Erlich J, Pyo R, Gutstein D, Zhang J, Castellino F, Melis E, Carmeliet P, Baretton G, Luther T, Taubman M, Rosen E, Mackman N (2002) Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction. Proc Natl Acad Sci USA 99:15333\u201315338. https:\/\/doi.org\/10.1073\/pnas.242501899","journal-title":"Proc Natl Acad Sci USA"},{"key":"771_CR40","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1161\/circulationaha.107.692764","volume":"116","author":"R Pawlinski","year":"2007","unstructured":"Pawlinski R, Tencati M, Hampton CR, Shishido T, Bullard TA, Casey LM, Andrade-Gordon P, Kotzsch M, Spring D, Luther T, Abe J, Pohlman TH, Verrier ED, Blaxall BC, Mackman N (2007) Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy. Circulation 116:2298\u20132306. https:\/\/doi.org\/10.1161\/circulationaha.107.692764","journal-title":"Circulation"},{"key":"771_CR41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.toxlet.2017.11.018","volume":"284","author":"Z Pei","year":"2018","unstructured":"Pei Z, Deng Q, Babcock SA, He EY, Ren J, Zhang Y (2018) Inhibition of advanced glycation endproduct (age) rescues against streptozotocin-induced diabetic cardiomyopathy: role of autophagy and er stress. Toxicol Lett 284:10\u201320. https:\/\/doi.org\/10.1016\/j.toxlet.2017.11.018","journal-title":"Toxicol Lett"},{"key":"771_CR42","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12933-018-0783-z","volume":"17","author":"L Pretorius","year":"2018","unstructured":"Pretorius L, Thomson GJA, Adams RCM, Nell TA, Laubscher WA, Pretorius E (2018) Platelet activity and hypercoagulation in type 2 diabetes. Cardiovasc Diabetol 17:141. https:\/\/doi.org\/10.1186\/s12933-018-0783-z","journal-title":"Cardiovasc Diabetol"},{"key":"771_CR43","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.atherosclerosis.2011.09.035","volume":"220","author":"F Pruller","year":"2012","unstructured":"Pruller F, Raggam RB, Posch V, Almer G, Truschnig-Wilders M, Horejsi R, Moller R, Weghuber D, Ille R, Schnedl W, Mangge H (2012) Trunk weighted obesity, cholesterol levels and low grade inflammation are main determinants for enhanced thrombin generation. Atherosclerosis 220:215\u2013218. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2011.09.035","journal-title":"Atherosclerosis"},{"key":"771_CR44","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.3324\/haematol.2018.191700","volume":"103","author":"J Qiao","year":"2018","unstructured":"Qiao J, Wu X, Luo Q, Wei G, Xu M, Wu Y, Liu Y, Li X, Zi J, Ju W, Fu L, Chen C, Wu Q, Zhu S, Qi K, Li D, Li Z, Andrews RK, Zeng L, Gardiner EE, Xu K (2018) Nlrp3 regulates platelet integrin alphaiibbeta3 outside-in signaling, hemostasis and arterial thrombosis. Haematologica 103:1568\u20131576. https:\/\/doi.org\/10.3324\/haematol.2018.191700","journal-title":"Haematologica"},{"key":"771_CR45","doi-asserted-by":"publisher","first-page":"5321","DOI":"10.1210\/jc.2003-030508","volume":"88","author":"M Romano","year":"2003","unstructured":"Romano M, Guagnano MT, Pacini G, Vigneri S, Falco A, Marinopiccoli M, Manigrasso MR, Basili S, Davi G (2003) Association of inflammation markers with impaired insulin sensitivity and coagulative activation in obese healthy women. J Clin Endocrinol Metab 88:5321\u20135326. https:\/\/doi.org\/10.1210\/jc.2003-030508","journal-title":"J Clin Endocrinol Metab"},{"key":"771_CR46","doi-asserted-by":"publisher","first-page":"23944","DOI":"10.1074\/jbc.M302718200","volume":"278","author":"A Sabri","year":"2003","unstructured":"Sabri A, Alcott SG, Elouardighi H, Pak E, Derian C, Andrade-Gordon P, Kinnally K, Steinberg SF (2003) Neutrophil cathepsin G promotes detachment-induced cardiomyocyte apoptosis via a protease-activated receptor-independent mechanism. J Biol Chem 278:23944\u201323954. https:\/\/doi.org\/10.1074\/jbc.M302718200","journal-title":"J Biol Chem"},{"key":"771_CR47","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1186\/1756-0500-6-485","volume":"6","author":"B Sapkota","year":"2013","unstructured":"Sapkota B, Shrestha SK, Poudel S (2013) Association of activated partial thromboplastin time and fibrinogen level in patients with type ii diabetes mellitus. BMC Res Notes 6:485. https:\/\/doi.org\/10.1186\/1756-0500-6-485","journal-title":"BMC Res Notes"},{"key":"771_CR48","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ijcard.2018.10.020","volume":"287","author":"L Scott Jr","year":"2019","unstructured":"Scott L Jr, Li N, Dobrev D (2019) Role of inflammatory signaling in atrial fibrillation. Int J Cardiol 287:195\u2013200. https:\/\/doi.org\/10.1016\/j.ijcard.2018.10.020","journal-title":"Int J Cardiol"},{"key":"771_CR49","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3389\/fphys.2018.00114","volume":"9","author":"A Sharma","year":"2018","unstructured":"Sharma A, Tate M, Mathew G, Vince JE, Ritchie RH, de Haan JB (2018) Oxidative stress and nlrp3-inflammasome activity as significant drivers of diabetic cardiovascular complications: therapeutic implications. Front Physiol 9:114. https:\/\/doi.org\/10.3389\/fphys.2018.00114","journal-title":"Front Physiol"},{"key":"771_CR50","doi-asserted-by":"publisher","first-page":"4540","DOI":"10.1096\/fj.12-213496","volume":"26","author":"AN Snead","year":"2012","unstructured":"Snead AN, Insel PA (2012) Defining the cellular repertoire of gpcrs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts. FASEB J 26:4540\u20134547. https:\/\/doi.org\/10.1096\/fj.12-213496","journal-title":"FASEB J"},{"key":"771_CR51","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00011-017-1030-x","volume":"66","author":"P Soma","year":"2017","unstructured":"Soma P, Swanepoel AC, Bester J, Pretorius E (2017) Tissue factor levels in type 2 diabetes mellitus. Inflamm Res 66:365\u2013368. https:\/\/doi.org\/10.1007\/s00011-017-1030-x","journal-title":"Inflamm Res"},{"key":"771_CR52","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1177\/1074248413485434","volume":"18","author":"DL Sonin","year":"2013","unstructured":"Sonin DL, Wakatsuki T, Routhu KV, Harmann LM, Petersen M, Meyer J, Strande JL (2013) Protease-activated receptor 1 inhibition by sch79797 attenuates left ventricular remodeling and profibrotic activities of cardiac fibroblasts. J Cardiovasc Pharmacol Ther 18:460\u2013475. https:\/\/doi.org\/10.1177\/1074248413485434","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"771_CR53","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1006\/excr.1998.4372","volume":"247","author":"LE Sower","year":"1999","unstructured":"Sower LE, Payne DA, Meyers R, Carney DH (1999) Thrombin peptide, tp508, induces differential gene expression in fibroblasts through a nonproteolytic activation pathway. Exp Cell Res 247:422\u2013431. https:\/\/doi.org\/10.1006\/excr.1998.4372","journal-title":"Exp Cell Res"},{"key":"771_CR54","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1038\/oby.2012.85","volume":"20","author":"S Stoppa-Vaucher","year":"2012","unstructured":"Stoppa-Vaucher S, Dirlewanger MA, Meier CA, de Moerloose P, Reber G, Roux-Lombard P, Combescure C, Saudan S, Schwitzgebel VM (2012) Inflammatory and prothrombotic states in obese children of European descent. Obesity (Silver Spring) 20:1662\u20131668. https:\/\/doi.org\/10.1038\/oby.2012.85","journal-title":"Obesity (Silver Spring)"},{"key":"771_CR55","doi-asserted-by":"publisher","DOI":"10.1097\/fjc.0000000000000709","author":"M Takahashi","year":"2019","unstructured":"Takahashi M (2019) Cell-specific roles of nlrp3 inflammasome in myocardial infarction. J Cardiovasc Pharmacol. https:\/\/doi.org\/10.1097\/fjc.0000000000000709","journal-title":"J Cardiovasc Pharmacol"},{"key":"771_CR56","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6448","author":"Y Wang","year":"2019","unstructured":"Wang Y, Li H, Li Y, Zhao Y, Xiong F, Liu Y, Xue H, Yang Z, Ni S, Sahil A, Che H, Wang L (2019) Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and nlrp3 inflammasome activation. Phytother Res. https:\/\/doi.org\/10.1002\/ptr.6448","journal-title":"Phytother Res"},{"key":"771_CR57","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.2337\/db06-1662","volume":"56","author":"D Westermann","year":"2007","unstructured":"Westermann D, Van Linthout S, Dhayat S, Dhayat N, Escher F, Bucker-Gartner C, Spillmann F, Noutsias M, Riad A, Schultheiss HP, Tschope C (2007) Cardioprotective and anti-inflammatory effects of interleukin converting enzyme inhibition in experimental diabetic cardiomyopathy. Diabetes 56:1834\u20131841. https:\/\/doi.org\/10.2337\/db06-1662","journal-title":"Diabetes"},{"key":"771_CR58","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1136\/heartjnl-2017-311448","volume":"104","author":"AJ Wilson","year":"2018","unstructured":"Wilson AJ, Gill EK, Abudalo RA, Edgar KS, Watson CJ, Grieve DJ (2018) Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting. Heart 104:293\u2013299. https:\/\/doi.org\/10.1136\/heartjnl-2017-311448","journal-title":"Heart"},{"key":"771_CR59","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1161\/atvbaha.117.310104","volume":"38","author":"SJ Wilson","year":"2018","unstructured":"Wilson SJ, Ismat FA, Wang Z, Cerra M, Narayan H, Raftis J, Gray TJ, Connell S, Garonzik S, Ma X, Yang J, Newby DE (2018) Par4 (protease-activated receptor 4) antagonism with bms-986120 inhibits human ex vivo thrombus formation. Arterioscler Thromb Vasc Biol 38:448\u2013456. https:\/\/doi.org\/10.1161\/atvbaha.117.310104","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"771_CR60","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf5294","author":"PC Wong","year":"2017","unstructured":"Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J (2017) Blockade of protease-activated receptor-4 (par4) provides robust antithrombotic activity with low bleeding. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.aaf5294","journal-title":"Sci Transl Med"},{"key":"771_CR61","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.bbadis.2014.05.006","volume":"1852","author":"L Yang","year":"2015","unstructured":"Yang L, Zhao D, Ren J, Yang J (2015) Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy. Biochim Biophys Acta 1852:209\u2013218. https:\/\/doi.org\/10.1016\/j.bbadis.2014.05.006","journal-title":"Biochim Biophys Acta"},{"key":"771_CR62","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1161\/circulationaha.118.035202","volume":"138","author":"C Yao","year":"2018","unstructured":"Yao C, Veleva T, Scott L Jr, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha ID, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Muller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N (2018) Enhanced cardiomyocyte nlrp3 inflammasome signaling promotes atrial fibrillation. Circulation 138:2227\u20132242. https:\/\/doi.org\/10.1161\/circulationaha.118.035202","journal-title":"Circulation"},{"key":"771_CR63","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.bbrc.2017.02.019","volume":"485","author":"X Ye","year":"2017","unstructured":"Ye X, Zuo D, Yu L, Zhang L, Tang J, Cui C, Bao L, Zan K, Zhang Z, Yang X, Chen H, Tang H, Zu J, Shi H, Cui G (2017) Ros\/txnip pathway contributes to thrombin induced nlrp3 inflammasome activation and cell apoptosis in microglia. Biochem Biophys Res Commun 485:499\u2013505. https:\/\/doi.org\/10.1016\/j.bbrc.2017.02.019","journal-title":"Biochem Biophys Res Commun"},{"key":"771_CR64","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s10557-017-6725-2","volume":"31","author":"Y Ye","year":"2017","unstructured":"Ye Y, Bajaj M, Yang HC, Perez-Polo JR, Birnbaum Y (2017) Sglt-2 inhibition with dapagliflozin reduces the activation of the nlrp3\/asc inflammasome and attenuates the development of diabetic cardiomyopathy in mice with type 2 diabetes. Further augmentation of the effects with saxagliptin, a dpp4 inhibitor. Cardiovasc Drugs Ther 31:119\u2013132. https:\/\/doi.org\/10.1007\/s10557-017-6725-2","journal-title":"Cardiovasc Drugs Ther"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-019-0771-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00395-019-0771-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-019-0771-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:39:47Z","timestamp":1609893587000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00395-019-0771-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,7]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["771"],"URL":"https:\/\/doi.org\/10.1007\/s00395-019-0771-9","relation":{},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,7]]},"assertion":[{"value":"8 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"D. Dobrev is a member of the scientific advisory board of OMEICOS Therapeutics GmbH, a company developing small molecules mimicking the effects of omega-3 fatty acids, and of Acesion Pharma, a company developing selective blockers of small-conductance calcium-dependent potassium channels.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All human and animal studies were approved by the institutional ethics committees and were performed in accordance with the ethical standards laid down by the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients gave written informed consent prior to inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"10"}}