{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:51:15Z","timestamp":1780419075436,"version":"3.54.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL136386"],"award-info":[{"award-number":["HL136386"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL116769"],"award-info":[{"award-number":["HL116769"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL095590"],"award-info":[{"award-number":["HL095590"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["EB026518"],"award-info":[{"award-number":["EB026518"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["OD023438"],"award-info":[{"award-number":["OD023438"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["OD011140"],"award-info":[{"award-number":["OD011140"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00395-021-00879-3","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T22:02:15Z","timestamp":1621548135000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mineralocorticoid receptor blockade normalizes coronary resistance in obese swine independent of functional alterations in Kv channels"],"prefix":"10.1007","volume":"116","author":[{"given":"Adam G.","family":"Goodwill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana E.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia E.","family":"McCallinhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chastidy A.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darla L.","family":"Tharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah E.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca S.","family":"Blaettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris Z.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas K.","family":"Bowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron J.","family":"Trask","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathan D.","family":"Tune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4709-1387","authenticated-orcid":false,"given":"Shawn B.","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"879_CR1","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1161\/hypertensionaha.115.06172","volume":"66","author":"K Barrett Mueller","year":"2015","unstructured":"Barrett Mueller K, Bender SB, Hong K, Yang Y, Aronovitz M, Jaisser F, Hill MA, Jaffe IZ (2015) Endothelial mineralocorticoid receptors differentially contribute to coronary and mesenteric vascular function without modulating blood pressure. Hypertension 66:988\u2013997. https:\/\/doi.org\/10.1161\/hypertensionaha.115.06172","journal-title":"Hypertension"},{"key":"879_CR2","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1152\/japplphysiol.00946.2011","volume":"111","author":"SB Bender","year":"2011","unstructured":"Bender SB, Berwick ZC, Laughlin MH, Tune JD (2011) Functional contribution of P2Y1 receptors to the control of coronary blood flow. J Appl Physiol 111:1744\u20131750. https:\/\/doi.org\/10.1152\/japplphysiol.00946.2011","journal-title":"J Appl Physiol"},{"key":"879_CR3","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1161\/hypertensionaha.114.04912","volume":"65","author":"SB Bender","year":"2015","unstructured":"Bender SB, DeMarco VG, Padilla J, Jenkins NT, Habibi J, Garro M, Pulakat L, Aroor AR, Jaffe IZ, Sowers JR (2015) Mineralocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction. Hypertension 65:1082\u20131088. https:\/\/doi.org\/10.1161\/hypertensionaha.114.04912","journal-title":"Hypertension"},{"key":"879_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2337\/db14-1425","volume":"64","author":"SB Bender","year":"2015","unstructured":"Bender SB, Jia G, Sowers JR (2015) Mineralocorticoid receptors: an appealing target to treat coronary microvascular dysfunction in diabetes. Diabetes 64:3\u20135. https:\/\/doi.org\/10.2337\/db14-1425","journal-title":"Diabetes"},{"key":"879_CR5","doi-asserted-by":"publisher","first-page":"683","DOI":"10.3181\/0812-RM-350","volume":"234","author":"SB Bender","year":"2009","unstructured":"Bender SB, Tune JD, Borbouse L, Long X, Sturek M, Laughlin MH (2009) Altered mechanism of adenosine-induced coronary arteriolar dilation in early-stage metabolic syndrome. Exp Biol Med (Maywood) 234:683\u2013692. https:\/\/doi.org\/10.3181\/0812-RM-350","journal-title":"Exp Biol Med (Maywood)"},{"key":"879_CR6","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.yjmcc.2011.07.004","volume":"52","author":"ZC Berwick","year":"2012","unstructured":"Berwick ZC, Dick GM, Moberly SP, Kohr MC, Sturek M, Tune JD (2012) Contribution of voltage-dependent K+ channels to metabolic control of coronary blood flow. J Mol Cell Cardiol 52:912\u2013919. https:\/\/doi.org\/10.1016\/j.yjmcc.2011.07.004","journal-title":"J Mol Cell Cardiol"},{"key":"879_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/ajh\/hpy158","volume":"32","author":"LA Biwer","year":"2019","unstructured":"Biwer LA, Wallingford MC, Jaffe IZ (2019) Vascular mineralocorticoid receptor: evolutionary mediator of wound healing turned harmful by our modern lifestyle. Am J Hypertens 32:123\u2013134. https:\/\/doi.org\/10.1093\/ajh\/hpy158","journal-title":"Am J Hypertens"},{"key":"879_CR8","doi-asserted-by":"publisher","first-page":"H1629","DOI":"10.1152\/ajpheart.00466.2009","volume":"297","author":"L Borbouse","year":"2009","unstructured":"Borbouse L, Dick GM, Asano S, Bender SB, Dincer UD, Payne GA, Neeb ZP, Bratz IN, Sturek M, Tune JD (2009) Impaired function of coronary BK(Ca) channels in metabolic syndrome. Am J Physiol Heart Circ Physiol 297:H1629-1637. https:\/\/doi.org\/10.1152\/ajpheart.00466.2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"879_CR9","doi-asserted-by":"publisher","first-page":"H1126","DOI":"10.1152\/ajpheart.00898.2014","volume":"308","author":"B Bostick","year":"2015","unstructured":"Bostick B, Habibi J, DeMarco VG, Jia G, Domeier TL, Lambert MD, Aroor AR, Nistala R, Bender SB, Garro M, Hayden MR, Ma L, Manrique C, Sowers JR (2015) Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice. Am J Physiol Heart Circ Physiol 308:H1126-1135. https:\/\/doi.org\/10.1152\/ajpheart.00898.2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"879_CR10","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1152\/jappl.1998.84.4.1225","volume":"84","author":"DK Bowles","year":"1998","unstructured":"Bowles DK, Laughlin MH, Sturek M (1998) Exercise training increases K+ channel contribution to regulation of coronary arterial tone. J Appl Physiol 84:1225\u20131233. https:\/\/doi.org\/10.1152\/jappl.1998.84.4.1225","journal-title":"J Appl Physiol"},{"key":"879_CR11","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.phrs.2018.06.002","volume":"134","author":"SM Brown","year":"2018","unstructured":"Brown SM, Meuth AI, Davis JW, Rector RS, Bender SB (2018) Mineralocorticoid receptor antagonism reverses diabetes-related coronary vasodilator dysfunction: a unique vascular transcriptomic signature. Pharmacol Res 134:100\u2013108. https:\/\/doi.org\/10.1016\/j.phrs.2018.06.002","journal-title":"Pharmacol Res"},{"key":"879_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jchf.2019.09.009","volume":"8","author":"JB Cohen","year":"2020","unstructured":"Cohen JB, Schrauben SJ, Zhao L, Basso MD, Cvijic ME, Li Z, Yarde M, Wang Z, Bhattacharya PT, Chirinos DA, Prenner S, Zamani P, Seiffert DA, Car BD, Gordon DA, Margulies K, Cappola T, Chirinos JA (2020) Clinical phenogroups in heart failure with preserved ejection fraction: detailed phenotypes, prognosis, and response to spironolactone. JACC Heart Fail 8:172\u2013184. https:\/\/doi.org\/10.1016\/j.jchf.2019.09.009","journal-title":"JACC Heart Fail"},{"key":"879_CR13","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.117.007675","author":"AP Davel","year":"2018","unstructured":"Davel AP, Lu Q, Moss ME, Rao S, Anwar IJ, DuPont JJ, Jaffe IZ (2018) Sex-specific mechanisms of resistance vessel endothelial dysfunction induced by cardiometabolic risk factors. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/jaha.117.007675","journal-title":"J Am Heart Assoc"},{"key":"879_CR14","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1161\/hypertensionaha.115.05674","volume":"66","author":"VG DeMarco","year":"2015","unstructured":"DeMarco VG, Habibi J, Jia G, Aroor AR, Ramirez-Perez FI, Martinez-Lemus LA, Bender SB, Garro M, Hayden MR, Sun Z, Meininger GA, Manrique C, Whaley-Connell A, Sowers JR (2015) Low-dose mineralocorticoid receptor blockade prevents western diet-induced arterial stiffening in female mice. Hypertension 66:99\u2013107. https:\/\/doi.org\/10.1161\/hypertensionaha.115.05674","journal-title":"Hypertension"},{"key":"879_CR15","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1152\/physrev.00045.2006","volume":"88","author":"DJ Duncker","year":"2008","unstructured":"Duncker DJ, Bache RJ (2008) Regulation of coronary blood flow during exercise. Physiol Rev 88:1009\u20131086. https:\/\/doi.org\/10.1152\/physrev.00045.2006","journal-title":"Physiol Rev"},{"key":"879_CR16","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1161\/hypertensionaha.113.01273","volume":"63","author":"JJ DuPont","year":"2014","unstructured":"DuPont JJ, Hill MA, Bender SB, Jaisser F, Jaffe IZ (2014) Aldosterone and vascular mineralocorticoid receptors: regulators of ion channels beyond the kidney. Hypertension 63:632\u2013637. https:\/\/doi.org\/10.1161\/hypertensionaha.113.01273","journal-title":"Hypertension"},{"key":"879_CR17","doi-asserted-by":"publisher","first-page":"T67","DOI":"10.1530\/joe-17-0009","volume":"234","author":"JJ DuPont","year":"2017","unstructured":"DuPont JJ, Jaffe IZ (2017) 30 Years of the mineralocorticoid receptor: the role of the mineralocorticoid receptor in the vasculature. J Endocrinol 234:T67\u2013T82. https:\/\/doi.org\/10.1530\/joe-17-0009","journal-title":"J Endocrinol"},{"key":"879_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.01.018","author":"K Elkholey","year":"2021","unstructured":"Elkholey K, Papadimitriou L, Butler J, Thadani U, Stavrakis S (2021) Effect of obesity on response to spironolactone in patients with heart failure with preserved ejection fraction. Am J Cardiol. https:\/\/doi.org\/10.1016\/j.amjcard.2021.01.018","journal-title":"Am J Cardiol"},{"key":"879_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.11.010","author":"JP Ferreira","year":"2021","unstructured":"Ferreira JP, Verdonschot J, Wang P, Pizard A, Collier T, Ahmed FZ, Brunner-La-Rocca H-P, Clark AL, Cosmi F, Cuthbert J, D\u00edez J, Edelmann F, Girerd N, Gonz\u00e1lez A, Grojean S, Hazebroek M, Khan J, Latini R, Mamas MA, Mariottoni B, Mujaj B, Pellicori P, Petutschnigg J, Pieske B, Rossignol P, Rouet P, Staessen JA, Cleland JGF, Heymans S, Zannad F (2021) Proteomic and mechanistic analysis of spironolactone in patients at risk for HF. JACC Heart Fail. https:\/\/doi.org\/10.1016\/j.jchf.2020.11.010","journal-title":"JACC Heart Fail"},{"key":"879_CR20","doi-asserted-by":"publisher","first-page":"236","DOI":"10.2337\/db14-0670","volume":"64","author":"R Garg","year":"2015","unstructured":"Garg R, Rao AD, Baimas-George M, Hurwitz S, Foster C, Shah RV, Jerosch-Herold M, Kwong RY, Di Carli MF, Adler GK (2015) Mineralocorticoid receptor blockade improves coronary microvascular function in individuals with type 2 diabetes. Diabetes 64:236\u2013242. https:\/\/doi.org\/10.2337\/db14-0670","journal-title":"Diabetes"},{"key":"879_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-016-0575-0","volume":"111","author":"AG Goodwill","year":"2016","unstructured":"Goodwill AG, Noblet JN, Sassoon D, Fu L, Kassab GS, Schepers L, Herring BP, Rottgen TS, Tune JD, Dick GM (2016) Critical contribution of KV1 channels to the regulation of coronary blood flow. Basic Res Cardiol 111:1\u201313. https:\/\/doi.org\/10.1007\/s00395-016-0575-0","journal-title":"Basic Res Cardiol"},{"key":"879_CR22","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1152\/japplphysiol.00566.2001","volume":"92","author":"CL Heaps","year":"2002","unstructured":"Heaps CL, Bowles DK (2002) Gender-specific K(+)-channel contribution to adenosine-induced relaxation in coronary arterioles. J Appl Physiol 92:550\u2013558. https:\/\/doi.org\/10.1152\/japplphysiol.00566.2001","journal-title":"J Appl Physiol"},{"key":"879_CR23","doi-asserted-by":"publisher","first-page":"H568","DOI":"10.1152\/ajpheart.00157.2004","volume":"288","author":"CL Heaps","year":"2005","unstructured":"Heaps CL, Tharp DL, Bowles DK (2005) Hypercholesterolemia abolishes voltage-dependent K+ channel contribution to adenosine-mediated relaxation in porcine coronary arterioles. Am J Physiol Heart Circ Physiol 288:H568\u2013H576. https:\/\/doi.org\/10.1152\/ajpheart.00157.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"879_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/bph.12424","volume":"171","author":"ER Hedegaard","year":"2014","unstructured":"Hedegaard ER, Nielsen BD, Kun A, Hughes AD, Kr\u00f8igaard C, Mogensen S, Matchkov VV, Fr\u00f6bert O, Simonsen U (2014) KV7 channels are involved in hypoxia-induced vasodilatation of porcine coronary arteries. Br J Pharmacol 171:69\u201382. https:\/\/doi.org\/10.1111\/bph.12424","journal-title":"Br J Pharmacol"},{"key":"879_CR25","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1161\/01.RES.0000159937.05502.d1","volume":"96","author":"IZ Jaffe","year":"2005","unstructured":"Jaffe IZ, Mendelsohn ME (2005) Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circ Res 96:643\u2013650. https:\/\/doi.org\/10.1161\/01.RES.0000159937.05502.d1","journal-title":"Circ Res"},{"key":"879_CR26","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12933-020-01028-1","volume":"19","author":"L Jiang","year":"2020","unstructured":"Jiang L, Shi K, Guo Y-k, Ren Y, Li Z-l, Xia C-c, Li L, Liu X, Xie L-j, Gao Y, Shen M-t, Deng M-y, Yang Z-g (2020) The additive effects of obesity on myocardial microcirculation in diabetic individuals: a cardiac magnetic resonance first-pass perfusion study. Cardiovasc Diabetol 19:52. https:\/\/doi.org\/10.1186\/s12933-020-01028-1","journal-title":"Cardiovasc Diabetol"},{"key":"879_CR27","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1210\/jc.2007-0393","volume":"92","author":"HV Joffe","year":"2007","unstructured":"Joffe HV, Kwong RY, Gerhard-Herman MD, Rice C, Feldman K, Adler GK (2007) Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus. J Clin Endocrinol Metab 92:2552\u20132558. https:\/\/doi.org\/10.1210\/jc.2007-0393","journal-title":"J Clin Endocrinol Metab"},{"key":"879_CR28","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s00395-011-0201-0","volume":"106","author":"PS Katz","year":"2011","unstructured":"Katz PS, Trask AJ, Souza-Smith FM, Hutchinson KR, Galantowicz ML, Lord KC, Stewart JA Jr, Cismowski MJ, Varner KJ, Lucchesi PA (2011) Coronary arterioles in type 2 diabetic (db\/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness. Basic Res Cardiol 106:1123\u20131134. https:\/\/doi.org\/10.1007\/s00395-011-0201-0","journal-title":"Basic Res Cardiol"},{"key":"879_CR29","doi-asserted-by":"publisher","first-page":"H357","DOI":"10.1152\/ajpheart.00081.2019","volume":"317","author":"M Khan","year":"2019","unstructured":"Khan M, Meuth AI, Brown SM, Chandrasekar B, Bowles DK, Bender SB (2019) Aldosterone impairs coronary adenosine-mediated vasodilation via reduced functional expression of Ca2+-activated K+ channels. Am J Physiol Heart Circ Physiol 317:H357\u2013H363. https:\/\/doi.org\/10.1152\/ajpheart.00081.2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"879_CR30","doi-asserted-by":"publisher","first-page":"e007279","DOI":"10.1161\/circheartfailure.120.007279","volume":"14","author":"SK Kim","year":"2021","unstructured":"Kim SK, Biwer LA, Moss ME, Man JJ, Aronovitz MJ, Martin GL, Carrillo-Salinas FJ, Salvador AM, Alcaide P, Jaffe IZ (2021) Mineralocorticoid receptor in smooth muscle contributes to pressure overload-induced heart failure. Circ Heart Fail 14:e007279. https:\/\/doi.org\/10.1161\/circheartfailure.120.007279","journal-title":"Circ Heart Fail"},{"key":"879_CR31","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1161\/hypertensionaha.117.10437","volume":"71","author":"SK Kim","year":"2018","unstructured":"Kim SK, McCurley AT, DuPont JJ, Aronovitz M, Moss ME, Stillman IE, Karumanchi SA, Christou DD, Jaffe IZ (2018) Smooth muscle cell-mineralocorticoid receptor as a mediator of cardiovascular stiffness with aging. Hypertension 71:609\u2013621. https:\/\/doi.org\/10.1161\/hypertensionaha.117.10437","journal-title":"Hypertension"},{"key":"879_CR32","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/sj.bjp.0700939","volume":"120","author":"Q Liu","year":"1997","unstructured":"Liu Q, Flavahan NA (1997) Hypoxic dilatation of porcine small coronary arteries: role of endothelium and KATP-channels. Br J Pharmacol 120:728\u2013734. https:\/\/doi.org\/10.1038\/sj.bjp.0700939","journal-title":"Br J Pharmacol"},{"key":"879_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01463","author":"PE McCallinhart","year":"2018","unstructured":"McCallinhart PE, Sunyecz IL, Trask AJ (2018) Coronary microvascular remodeling in type 2 diabetes: synonymous with early aging? Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2018.01463","journal-title":"Front Physiol"},{"key":"879_CR34","doi-asserted-by":"publisher","first-page":"H2184","DOI":"10.1152\/ajpheart.1993.265.6.H2184","volume":"265","author":"AL Miller","year":"1993","unstructured":"Miller AL, Morales E, Leblanc NR, Cole WC (1993) Metabolic inhibition enhances Ca2+-activated K+ current in smooth muscle cells of rabbit portal vein. Am J Physiol 265:H2184\u2013H2195. https:\/\/doi.org\/10.1152\/ajpheart.1993.265.6.H2184","journal-title":"Am J Physiol"},{"key":"879_CR35","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1161\/01.res.0000052671.53256.49","volume":"92","author":"H Miura","year":"2003","unstructured":"Miura H, Wachtel RE, Loberiza FR Jr, Saito T, Miura M, Nicolosi AC, Gutterman DD (2003) Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channels. Circ Res 92:151\u2013158. https:\/\/doi.org\/10.1161\/01.res.0000052671.53256.49","journal-title":"Circ Res"},{"key":"879_CR36","doi-asserted-by":"publisher","first-page":"107387","DOI":"10.1016\/j.pharmthera.2019.06.009","volume":"203","author":"ME Moss","year":"2019","unstructured":"Moss ME, Carvajal B, Jaffe IZ (2019) The endothelial mineralocorticoid receptor: contributions to sex differences in cardiovascular disease. Pharmacol Ther 203:107387. https:\/\/doi.org\/10.1016\/j.pharmthera.2019.06.009","journal-title":"Pharmacol Ther"},{"key":"879_CR37","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1161\/CIRCULATIONAHA.112.120402","volume":"126","author":"VL Murthy","year":"2012","unstructured":"Murthy VL, Naya M, Foster CR, Gaber M, Hainer J, Klein J, Dorbala S, Blankstein R, Di Carli MF (2012) Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus. Circulation 126:1858\u20131868. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.120402","journal-title":"Circulation"},{"key":"879_CR38","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1161\/HYPERTENSIONAHA.111.185520","volume":"59","author":"M Nagase","year":"2012","unstructured":"Nagase M, Ayuzawa N, Kawarazaki W, Ishizawa K, Ueda K, Yoshida S, Fujita T (2012) Oxidative stress causes mineralocorticoid receptor activation in rat cardiomyocytes. Hypertension 59:500\u2013506. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.111.185520","journal-title":"Hypertension"},{"key":"879_CR39","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1161\/circresaha.115.306642","volume":"117","author":"V Ohanyan","year":"2015","unstructured":"Ohanyan V, Yin L, Bardakjian R, Kolz C, Enrick M, Hakobyan T, Kmetz J, Bratz I, Luli J, Nagane M, Khan N, Hou H, Kuppusamy P, Graham J, Fu FK, Janota D, Oyewumi MO, Logan S, Lindner JR, Chilian WM (2015) Requisite role of Kv1.5 channels in coronary metabolic dilation. Circ Res 117:612\u2013621. https:\/\/doi.org\/10.1161\/circresaha.115.306642","journal-title":"Circ Res"},{"key":"879_CR40","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","volume":"62","author":"WJ Paulus","year":"2013","unstructured":"Paulus WJ, Tsch\u00f6pe C (2013) A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol 62:263\u2013271. https:\/\/doi.org\/10.1016\/j.jacc.2013.02.092","journal-title":"J Am Coll Cardiol"},{"key":"879_CR41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1161\/circulationaha.114.013255","volume":"131","author":"MA Pfeffer","year":"2015","unstructured":"Pfeffer MA, Claggett B, Assmann SF, Boineau R, Anand IS, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Heitner JF, Lewis EF, O\u2019Meara E, Rouleau J-L, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, McKinlay SM, Pitt B (2015) Regional variation in patients and outcomes in the treatment of preserved cardiac function heart failure with an aldosterone antagonist (TOPCAT) trial. Circulation 131:34\u201342. https:\/\/doi.org\/10.1161\/circulationaha.114.013255","journal-title":"Circulation"},{"key":"879_CR42","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1161\/01.cir.89.3.1254","volume":"89","author":"V Richard","year":"1994","unstructured":"Richard V, Kaeffer N, Tron C, Thuillez C (1994) Ischemic preconditioning protects against coronary endothelial dysfunction induced by ischemia and reperfusion. Circulation 89:1254\u20131261. https:\/\/doi.org\/10.1161\/01.cir.89.3.1254","journal-title":"Circulation"},{"key":"879_CR43","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1093\/eurheartj\/eht095","volume":"34","author":"N Schafer","year":"2013","unstructured":"Schafer N, Lohmann C, Winnik S, van Tits LJ, Miranda MX, Vergopoulos A, Ruschitzka F, Nussberger J, Berger S, Luscher TF, Verrey F, Matter CM (2013) Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity. Eur Heart J 34:3515\u20133524. https:\/\/doi.org\/10.1093\/eurheartj\/eht095","journal-title":"Eur Heart J"},{"key":"879_CR44","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1161\/HYPERTENSIONAHA.106.076083","volume":"50","author":"HD Schultz","year":"2007","unstructured":"Schultz HD, Li YL, Ding Y (2007) Arterial chemoreceptors and sympathetic nerve activity. Hypertension 50:6\u201313. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.106.076083","journal-title":"Hypertension"},{"key":"879_CR45","doi-asserted-by":"publisher","first-page":"e003995","DOI":"10.1161\/JAHA.116.003995","volume":"5","author":"M Sezer","year":"2016","unstructured":"Sezer M, Kocaaga M, Aslanger E, Atici A, Demirkiran A, Bugra Z, Umman S, Umman B (2016) Bimodal pattern of coronary microvascular involvement in diabetes mellitus. J Am Heart Assoc 5:e003995. https:\/\/doi.org\/10.1161\/JAHA.116.003995","journal-title":"J Am Heart Assoc"},{"key":"879_CR46","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1161\/CIRCULATIONAHA.114.010637","volume":"131","author":"SJ Shah","year":"2015","unstructured":"Shah SJ, Katz DH, Selvaraj S, Burke MA, Yancy CW, Gheorghiade M, Bonow RO, Huang C-C, Deo RC (2015) Phenomapping for novel classification of heart failure with preserved ejection fraction. Circulation 131:269\u2013279. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.010637","journal-title":"Circulation"},{"key":"879_CR47","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1161\/circulationaha.114.009716","volume":"131","author":"VR Taqueti","year":"2015","unstructured":"Taqueti VR, Everett BM, Murthy VL, Gaber M, Foster CR, Hainer J, Blankstein R, Dorbala S, Di Carli MF (2015) Interaction of impaired coronary flow reserve and cardiomyocyte injury on adverse cardiovascular outcomes in patients without overt coronary artery disease. Circulation 131:528\u2013535. https:\/\/doi.org\/10.1161\/circulationaha.114.009716","journal-title":"Circulation"},{"key":"879_CR48","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1093\/eurheartj\/ehx721","volume":"39","author":"VR Taqueti","year":"2018","unstructured":"Taqueti VR, Solomon SD, Shah AM, Desai AS, Groarke JD, Osborne MT, Hainer J, Bibbo CF, Dorbala S, Blankstein R, Di Carli MF (2018) Coronary microvascular dysfunction and future risk of heart failure with preserved ejection fraction. Eur Heart J 39:840\u2013849. https:\/\/doi.org\/10.1093\/eurheartj\/ehx721","journal-title":"Eur Heart J"},{"key":"879_CR49","doi-asserted-by":"publisher","first-page":"H247","DOI":"10.1152\/ajpheart.00569.2001","volume":"283","author":"GD Thorne","year":"2002","unstructured":"Thorne GD, Conforti L, Paul RJ (2002) Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca2+ channels. Am J Physiol Heart Circ Physiol 283:H247\u2013H253. https:\/\/doi.org\/10.1152\/ajpheart.00569.2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"879_CR50","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1152\/japplphysiol.00604.2012","volume":"113","author":"AJ Trask","year":"2012","unstructured":"Trask AJ, Katz PS, Kelly AP, Galantowicz ML, Cismowski MJ, West TA, Neeb ZP, Berwick ZC, Goodwill AG, Alloosh M, Tune JD, Sturek M, Lucchesi PA (2012) Dynamic micro- and macrovascular remodeling in coronary circulation of obese Ossabaw pigs with metabolic syndrome. J Appl Physiol 113:1128\u20131140. https:\/\/doi.org\/10.1152\/japplphysiol.00604.2012","journal-title":"J Appl Physiol"},{"key":"879_CR51","doi-asserted-by":"publisher","first-page":"H11","DOI":"10.1152\/ajpheart.00325.2019","volume":"318","author":"JD Tune","year":"2020","unstructured":"Tune JD, Goodwill AG, Kiel AM, Baker HE, Bender SB, Merkus D, Duncker DJ (2020) Disentangling the Gordian knot of local metabolic control of coronary blood flow. Am J Physiol Heart Circ Physiol 318:H11\u2013H24. https:\/\/doi.org\/10.1152\/ajpheart.00325.2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"879_CR52","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1113\/jphysiol.1991.sp018691","volume":"439","author":"KA Volk","year":"1991","unstructured":"Volk KA, Matsuda JJ, Shibata EF (1991) A voltage-dependent potassium current in rabbit coronary artery smooth muscle cells. J Physiol (Lond) 439:751\u2013768. https:\/\/doi.org\/10.1113\/jphysiol.1991.sp018691","journal-title":"J Physiol (Lond)"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-021-00879-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-021-00879-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-021-00879-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T18:08:02Z","timestamp":1642615682000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-021-00879-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,20]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["879"],"URL":"https:\/\/doi.org\/10.1007\/s00395-021-00879-3","relation":{},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,20]]},"assertion":[{"value":"8 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This manuscript does not contain clinical studies or patient data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"35"}}