{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:47:58Z","timestamp":1775807278879,"version":"3.50.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL135024"],"award-info":[{"award-number":["HL135024"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL135110"],"award-info":[{"award-number":["HL135110"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL135110"],"award-info":[{"award-number":["HL135110"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL137008"],"award-info":[{"award-number":["HL137008"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL142710"],"award-info":[{"award-number":["HL142710"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fibus Family Foundation"},{"name":"Schermer Family Trust"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00395-021-00908-1","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T19:02:36Z","timestamp":1642446156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mitochondrial DNA integrity and function are critical for endothelium-dependent vasodilation in rats with metabolic syndrome"],"prefix":"10.1007","volume":"117","author":[{"given":"Takahiko","family":"Kiyooka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahagn","family":"Ohanyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liya","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh Fen","family":"Pung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong-Renn","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chwen-Lih","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick T.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"Hardwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Janota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Kolz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacinta","family":"Guarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Shokolenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donte A.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-7914","authenticated-orcid":false,"given":"William M.","family":"Chilian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"908_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1161\/01.hyp.25.2.155","volume":"25","author":"RW Alexander","year":"1995","unstructured":"Alexander RW (1995) Theodore cooper memorial lecture. Hypertension and the pathogenesis of atherosclerosis. Oxidative stress and the mediation of arterial inflammatory response: a new perspective. Hypertension 25:155\u2013161. https:\/\/doi.org\/10.1161\/01.hyp.25.2.155","journal-title":"Hypertension"},{"key":"908_CR2","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1016\/j.freeradbiomed.2005.02.014","volume":"38","author":"SW Ballinger","year":"2005","unstructured":"Ballinger SW (2005) Mitochondrial dysfunction in cardiovascular disease. Free Radic Biol Med 38:1278\u20131295. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2005.02.014","journal-title":"Free Radic Biol Med"},{"key":"908_CR3","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/0022-2828(92)93381-s","volume":"24","author":"E Barth","year":"1992","unstructured":"Barth E, Stammler G, Speiser B, Schaper J (1992) Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man. J Mol Cell Cardiol 24:669\u2013681. https:\/\/doi.org\/10.1016\/0022-2828(92)93381-s","journal-title":"J Mol Cell Cardiol"},{"key":"908_CR4","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1161\/01.CIR.94.12.3341","volume":"94","author":"J Bauersachs","year":"1996","unstructured":"Bauersachs J, Popp R, Hecker M, Sauer E, Fleming I, Busse R (1996) Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation 94:3341\u20133347","journal-title":"Circulation"},{"key":"908_CR5","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1161\/CIRCRESAHA.115.307918","volume":"118","author":"AM Beyer","year":"2016","unstructured":"Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ, Peleg R, Gasparri M, Rokkas CK, Santos JH, Priel E, Gutterman DD (2016) Critical role for telomerase in the mechanism of flow-mediated dilation in the human microcirculation. Circ Res 118:856\u2013866. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.307918","journal-title":"Circ Res"},{"key":"908_CR6","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1161\/01.atv.0000051384.43104.fc","volume":"23","author":"PO Bonetti","year":"2003","unstructured":"Bonetti PO, Lerman LO, Lerman A (2003) Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 23:168\u2013175. https:\/\/doi.org\/10.1161\/01.atv.0000051384.43104.fc","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"908_CR7","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1042\/BST0330897","volume":"33","author":"MD Brand","year":"2005","unstructured":"Brand MD (2005) The efficiency and plasticity of mitochondrial energy transduction. Biochem Soc Trans 33:897\u2013904. https:\/\/doi.org\/10.1042\/BST0330897","journal-title":"Biochem Soc Trans"},{"key":"908_CR8","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.freeradbiomed.2004.05.034","volume":"37","author":"MD Brand","year":"2004","unstructured":"Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N (2004) Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med 37:755\u2013767. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2004.05.034","journal-title":"Free Radic Biol Med"},{"key":"908_CR9","doi-asserted-by":"publisher","first-page":"H1085","DOI":"10.1152\/ajpheart.00648.2017","volume":"314","author":"SD Brooks","year":"2018","unstructured":"Brooks SD, Hileman SM, Chantler PD, Milde SA, Lemaster KA, Frisbee SJ, Shoemaker JK, Jackson DN, Frisbee JC (2018) Protection from chronic stress- and depressive symptom-induced vascular endothelial dysfunction in female rats is abolished by preexisting metabolic disease. Am J Physiol Heart Circ Physiol 314:H1085\u2013H1097. https:\/\/doi.org\/10.1152\/ajpheart.00648.2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"908_CR10","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1161\/01.res.87.10.840","volume":"87","author":"H Cai","year":"2000","unstructured":"Cai H, Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87:840\u2013844. https:\/\/doi.org\/10.1161\/01.res.87.10.840","journal-title":"Circ Res"},{"key":"908_CR11","first-page":"186","volume":"19","author":"MS Cannon","year":"1982","unstructured":"Cannon MS, Jones CE, Peterson TV (1982) A histochemical evaluation of metabolism in the coronary vasculature of the primate. Blood Vessels 19:186\u2013196","journal-title":"Blood Vessels"},{"key":"908_CR12","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1161\/01.ATV.0000122852.22604.78","volume":"24","author":"A Ceriello","year":"2004","unstructured":"Ceriello A, Motz E (2004) Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 24:816\u2013823. https:\/\/doi.org\/10.1161\/01.ATV.0000122852.22604.78","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"908_CR13","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1161\/01.res.0000185804.79157.c0","volume":"97","author":"SHH Chan","year":"2005","unstructured":"Chan SHH, Hsu K-S, Huang C-C, Wang L-L, Ou C-C, Chan JYH (2005) NADPH oxidase-derived superoxide anion mediates angiotensin II-induced pressor effect via activation of p38 mitogen-activated protein kinase in the rostral ventrolateral medulla. Circ Res 97:772\u2013780. https:\/\/doi.org\/10.1161\/01.res.0000185804.79157.c0","journal-title":"Circ Res"},{"key":"908_CR14","doi-asserted-by":"publisher","first-page":"5754","DOI":"10.1021\/bi602580c","volume":"46","author":"CL Chen","year":"2007","unstructured":"Chen CL, Zhang L, Yeh A, Chen CA, Green-Church KB, Zweier JL, Chen YR (2007) Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase. Biochemistry 46:5754\u20135765. https:\/\/doi.org\/10.1021\/bi602580c","journal-title":"Biochemistry"},{"key":"908_CR15","doi-asserted-by":"publisher","first-page":"32640","DOI":"10.1074\/jbc.M702294200","volume":"282","author":"YR Chen","year":"2007","unstructured":"Chen YR, Chen CL, Pfeiffer DR, Zweier JL (2007) Mitochondrial complex II in the post-ischemic Heart: Oxidative Injury And The Role Of Protein S-Glutathionylation. J Biol Chem 282:32640\u201332654","journal-title":"J Biol Chem"},{"key":"908_CR16","doi-asserted-by":"publisher","first-page":"4415","DOI":"10.1021\/bi992652+","volume":"39","author":"YR Chen","year":"2000","unstructured":"Chen YR, Deterding LJ, Tomer KB, Mason RP (2000) Nature of the inhibition of horseradish peroxidase and mitochondrial cytochrome c oxidase by cyanyl radical. Biochemistry 39:4415\u20134422. https:\/\/doi.org\/10.1021\/bi992652+","journal-title":"Biochemistry"},{"issue":"Suppl G","key":"908_CR17","first-page":"G3","volume":"19","author":"F Cosentino","year":"1998","unstructured":"Cosentino F, Luscher TF (1998) Tetrahydrobiopterin and endothelial function. Eur Heart J 19(Suppl G):G3-8","journal-title":"Eur Heart J"},{"key":"908_CR18","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1161\/01.res.0000020401.61826.ea","volume":"90","author":"A Csiszar","year":"2002","unstructured":"Csiszar A, Ungvari Z, Edwards JG, Kaminski P, Wolin MS, Koller A, Kaley G (2002) Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res 90:1159\u20131166. https:\/\/doi.org\/10.1161\/01.res.0000020401.61826.ea","journal-title":"Circ Res"},{"key":"908_CR19","doi-asserted-by":"publisher","first-page":"496","DOI":"10.2337\/diabetes.55.02.06.db05-1064","volume":"55","author":"BJ Davis","year":"2006","unstructured":"Davis BJ, Xie Z, Viollet B, Zou MH (2006) Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 55:496\u2013505. https:\/\/doi.org\/10.2337\/diabetes.55.02.06.db05-1064","journal-title":"Diabetes"},{"key":"908_CR20","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/sj.bjp.0703393","volume":"130","author":"AS De Vriese","year":"2000","unstructured":"De Vriese AS, Verbeuren TJ, Van de Voorde J, Lameire NH, Vanhoutte PM (2000) Endothelial dysfunction in diabetes. Br J Pharmacol 130:963\u2013974. https:\/\/doi.org\/10.1038\/sj.bjp.0703393","journal-title":"Br J Pharmacol"},{"key":"908_CR21","doi-asserted-by":"publisher","first-page":"21673","DOI":"10.1074\/jbc.M411531200","volume":"280","author":"NM Druzhyna","year":"2005","unstructured":"Druzhyna NM, Musiyenko SI, Wilson GL, LeDoux SP (2005) Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes. Protective role of targeting 8-oxoguanine glycosylase to mitochondria. J Biol Chem 280:21673\u201321679. https:\/\/doi.org\/10.1074\/jbc.M411531200","journal-title":"J Biol Chem"},{"key":"908_CR22","doi-asserted-by":"publisher","first-page":"H2093","DOI":"10.1152\/ajpheart.01202.2006","volume":"292","author":"M Focardi","year":"2007","unstructured":"Focardi M, Dick GM, Picchi A, Zhang C, Chilian WM (2007) Restoration of coronary endothelial function in obese Zucker rats by a low-carbohydrate diet. Am J Physiol Heart Circ Physiol 292:H2093-2099. https:\/\/doi.org\/10.1152\/ajpheart.01202.2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"908_CR23","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1161\/CIRCRESAHA.115.303881","volume":"115","author":"JK Freed","year":"2014","unstructured":"Freed JK, Beyer AM, LoGiudice JA, Hockenberry JC, Gutterman DD (2014) Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation. Circ Res 115:525\u2013532. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.303881","journal-title":"Circ Res"},{"key":"908_CR24","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1161\/CIRCULATIONAHA.106.650671","volume":"115","author":"X Gao","year":"2007","unstructured":"Gao X, Belmadani S, Picchi A, Xu X, Potter BJ, Tewari-Singh N, Capobianco S, Chilian WM, Zhang C (2007) Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation 115:245\u2013254. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.650671","journal-title":"Circulation"},{"key":"908_CR25","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/183469","volume":"2015","author":"KL Go","year":"2015","unstructured":"Go KL, Lee S, Zendejas I, Behrns KE, Kim JS (2015) Mitochondrial dysfunction and autophagy in hepatic ischemia\/reperfusion injury. Biomed Res Int 2015:183469. https:\/\/doi.org\/10.1155\/2015\/183469","journal-title":"Biomed Res Int"},{"key":"908_CR26","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00395-016-0547-4","volume":"111","author":"G Guarini","year":"2016","unstructured":"Guarini G, Kiyooka T, Ohanyan V, Pung YF, Marzilli M, Chen YR, Chen CL, Kang PT, Hardwick JP, Kolz CL, Yin L, Wilson GL, Shokolenko I, Dobson JG Jr, Fenton R, Chilian WM (2016) Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage. Basic Res Cardiol 111:29. https:\/\/doi.org\/10.1007\/s00395-016-0547-4","journal-title":"Basic Res Cardiol"},{"key":"908_CR27","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/978-1-59745-521-3_23","volume-title":"Mitochondrial DNA: Methods and Protocols","author":"K Hashiguchi","year":"2009","unstructured":"Hashiguchi K, Zhang-Akiyama Q-M (2009) Establishment of Human Cell Lines Lacking Mitochondrial DNA. In: Stuart JA (ed) Mitochondrial DNA: Methods and Protocols. Humana Press, Totowa, NJ, pp 383\u2013391"},{"key":"908_CR28","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1161\/01.str.21.7.1039","volume":"21","author":"K Hatake","year":"1990","unstructured":"Hatake K, Kakishita E, Wakabayashi I, Sakiyama N, Hishida S (1990) Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin. Stroke 21:1039\u20131043. https:\/\/doi.org\/10.1161\/01.str.21.7.1039","journal-title":"Stroke"},{"key":"908_CR29","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1161\/hc4601.099485","volume":"104","author":"T Heitzer","year":"2001","unstructured":"Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104:2673\u20132678. https:\/\/doi.org\/10.1161\/hc4601.099485","journal-title":"Circulation"},{"key":"908_CR30","doi-asserted-by":"publisher","first-page":"860","DOI":"10.7326\/0003-4819-123-11-199512010-00009","volume":"123","author":"P Jha","year":"1995","unstructured":"Jha P, Flather M, Lonn E, Farkouh M, Yusuf S (1995) The antioxidant vitamins and cardiovascular disease. A critical review of epidemiologic and clinical trial data. Ann Intern Med 123:860\u2013872. https:\/\/doi.org\/10.7326\/0003-4819-123-11-199512010-00009","journal-title":"Ann Intern Med"},{"key":"908_CR31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s00395-016-0546-5","volume":"111","author":"AO Kadlec","year":"2016","unstructured":"Kadlec AO, Beyer AM, Ait-Aissa K, Gutterman DD (2016) Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species. Basic Res Cardiol 111:26. https:\/\/doi.org\/10.1007\/s00395-016-0546-5","journal-title":"Basic Res Cardiol"},{"key":"908_CR32","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/s0033-0620(05)80003-9","volume":"38","author":"JF Keaney Jr","year":"1995","unstructured":"Keaney JF Jr, Vita JA (1995) Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action. Prog Cardiovasc Dis 38:129\u2013154. https:\/\/doi.org\/10.1016\/s0033-0620(05)80003-9","journal-title":"Prog Cardiovasc Dis"},{"key":"908_CR33","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/s0008-6363(97)00050-3","volume":"34","author":"MZ Koltai","year":"1997","unstructured":"Koltai MZ, Hadhazy P, Posa I, Kocsis E, Winkler G, Rosen P, Pogatsa G (1997) Characteristics of coronary endothelial dysfunction in experimental diabetes. Cardiovasc Res 34:157\u2013163. https:\/\/doi.org\/10.1016\/s0008-6363(97)00050-3","journal-title":"Cardiovasc Res"},{"key":"908_CR34","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1161\/01.ATV.0000188511.84138.9b","volume":"25","author":"R Koshida","year":"2005","unstructured":"Koshida R, Rocic P, Saito S, Kiyooka T, Zhang C, Chilian WM (2005) Role of focal adhesion kinase in flow-induced dilation of coronary arterioles. Arterioscler Thromb Vasc Biol 25:2548\u20132553. https:\/\/doi.org\/10.1161\/01.ATV.0000188511.84138.9b","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"908_CR35","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1161\/01.res.70.3.465","volume":"70","author":"L Kuo","year":"1992","unstructured":"Kuo L, Davis MJ, Cannon MS, Chilian WM (1992) Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginine. Circ Res 70:465\u2013476. https:\/\/doi.org\/10.1161\/01.res.70.3.465","journal-title":"Circ Res"},{"key":"908_CR36","doi-asserted-by":"publisher","first-page":"H1410","DOI":"10.1152\/ajpheart.00731.2011","volume":"302","author":"HL Lee","year":"2012","unstructured":"Lee HL, Chen CL, Yeh ST, Zweier JL, Chen YR (2012) Biphasic modulation of the mitochondrial electron transport chain in myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol 302:H1410-1422. https:\/\/doi.org\/10.1152\/ajpheart.00731.2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"908_CR37","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/s0014-5793(01)02901-5","volume":"506","author":"JF Leikert","year":"2001","unstructured":"Leikert JF, Rathel TR, Muller C, Vollmar AM, Dirsch VM (2001) Reliable in vitro measurement of nitric oxide released from endothelial cells using low concentrations of the fluorescent probe 4,5-diaminofluorescein. FEBS Lett 506:131\u2013134. https:\/\/doi.org\/10.1016\/s0014-5793(01)02901-5","journal-title":"FEBS Lett"},{"key":"908_CR38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063449","volume":"8","author":"NS Lobato","year":"2013","unstructured":"Lobato NS, Filgueira FP, Prakash R, Giachini FR, Ergul A, Carvalho MH, Webb RC, Tostes RC, Fortes ZB (2013) Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese Zucker rats. PLoS ONE 8:e63449. https:\/\/doi.org\/10.1371\/journal.pone.0063449","journal-title":"PLoS ONE"},{"key":"908_CR39","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1021\/pr400539j","volume":"13","author":"C Lotz","year":"2014","unstructured":"Lotz C, Lin AJ, Black CM, Zhang J, Lau E, Deng N, Wang Y, Zong NC, Choi JH, Xu T, Liem DA, Korge P, Weiss JN, Hermjakob H, Yates JR 3rd, Apweiler R, Ping P (2014) Characterization, design, and function of the mitochondrial proteome: from organs to organisms. J Proteome Res 13:433\u2013446. https:\/\/doi.org\/10.1021\/pr400539j","journal-title":"J Proteome Res"},{"key":"908_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000454812","volume":"54","author":"I Merdzo","year":"2017","unstructured":"Merdzo I, Rutkai I, Sure VN, McNulty CA, Katakam PV, Busija DW (2017) Impaired mitochondrial respiration in large cerebral arteries of rats with type 2 diabetes. J Vasc Res 54:1\u201312. https:\/\/doi.org\/10.1159\/000454812","journal-title":"J Vasc Res"},{"key":"908_CR41","doi-asserted-by":"publisher","first-page":"H830","DOI":"10.1152\/ajpheart.00964.2015","volume":"310","author":"I Merdzo","year":"2016","unstructured":"Merdzo I, Rutkai I, Tokes T, Sure VN, Katakam PV, Busija DW (2016) The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats. Am J Physiol Heart Circ Physiol 310:H830-838. https:\/\/doi.org\/10.1152\/ajpheart.00964.2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"908_CR42","doi-asserted-by":"publisher","first-page":"H2088","DOI":"10.1152\/ajpheart.00522.2003","volume":"288","author":"D Merkus","year":"2005","unstructured":"Merkus D, Brzezinska AK, Zhang C, Saito S, Chilian WM (2005) Cardiac myocytes control release of endothelin-1 in coronary vasculature. Am J Physiol Heart Circ Physiol 288:H2088-2092. https:\/\/doi.org\/10.1152\/ajpheart.00522.2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"908_CR43","doi-asserted-by":"publisher","first-page":"H1915","DOI":"10.1152\/ajpheart.00223.2002","volume":"283","author":"D Merkus","year":"2002","unstructured":"Merkus D, Duncker DJ, Chilian WM (2002) Metabolic regulation of coronary vascular tone: role of endothelin-1. Am J Physiol Heart Circ Physiol 283:H1915-1921. https:\/\/doi.org\/10.1152\/ajpheart.00223.2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"908_CR44","doi-asserted-by":"publisher","first-page":"31629","DOI":"10.1074\/jbc.M212831200","volume":"278","author":"VA Morrow","year":"2003","unstructured":"Morrow VA, Foufelle F, Connell JM, Petrie JR, Gould GW, Salt IP (2003) Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. J Biol Chem 278:31629\u201331639. https:\/\/doi.org\/10.1074\/jbc.M212831200","journal-title":"J Biol Chem"},{"key":"908_CR45","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.bbrc.2006.01.052","volume":"341","author":"H Murakami","year":"2006","unstructured":"Murakami H, Murakami R, Kambe F, Cao X, Takahashi R, Asai T, Hirai T, Numaguchi Y, Okumura K, Seo H, Murohara T (2006) Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC. Biochem Biophys Res Commun 341:973\u2013978. https:\/\/doi.org\/10.1016\/j.bbrc.2006.01.052","journal-title":"Biochem Biophys Res Commun"},{"key":"908_CR46","doi-asserted-by":"publisher","first-page":"H459","DOI":"10.1152\/ajpheart.2000.279.2.H459","volume":"279","author":"Y Nishikawa","year":"2000","unstructured":"Nishikawa Y, Stepp DW, Chilian WM (2000) Nitric oxide exerts feedback inhibition on EDHF-induced coronary arteriolar dilation in vivo. Am J Physiol Heart Circ Physiol 279:H459-465. https:\/\/doi.org\/10.1152\/ajpheart.2000.279.2.H459","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"908_CR47","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1161\/01.ATV.0000231511.26860.50","volume":"26","author":"M Oelze","year":"2006","unstructured":"Oelze M, Warnholtz A, Faulhaber J, Wenzel P, Kleschyov AL, Coldewey M, Hink U, Pongs O, Fleming I, Wassmann S, Meinertz T, Ehmke H, Daiber A, Munzel T (2006) NADPH oxidase accounts for enhanced superoxide production and impaired endothelium-dependent smooth muscle relaxation in BKbeta1-\/- mice. Arterioscler Thromb Vasc Biol 26:1753\u20131759. https:\/\/doi.org\/10.1161\/01.ATV.0000231511.26860.50","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"908_CR48","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/ana.410010502","volume":"1","author":"WH Oldendorf","year":"1977","unstructured":"Oldendorf WH, Cornford ME, Brown WJ (1977) The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann Neurol 1:409\u2013417. https:\/\/doi.org\/10.1002\/ana.410010502","journal-title":"Ann Neurol"},{"key":"908_CR49","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1161\/01.CIR.63.4.817","volume":"63","author":"D Opherk","year":"1981","unstructured":"Opherk D, Zebe H, Weihe E, Mall G, Durr C, Gravert B, Mehmel HC, Schwarz F, Kubler W (1981) Reduced coronary dilatory capacity and ultrastructural changes of the myocardium in patients with angina pectoris but normal coronary arteriograms. Circulation 63:817\u2013825","journal-title":"Circulation"},{"key":"908_CR50","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1161\/01.RES.0000109416.56608.64","volume":"94","author":"G Paradies","year":"2004","unstructured":"Paradies G, Petrosillo G, Pistolese M, Di Venosa N, Federici A, Ruggiero FM (2004) Decrease in mitochondrial complex I activity in ischemic\/reperfused rat heart: involvement of reactive oxygen species and cardiolipin. Circ Res 94:53\u201359. https:\/\/doi.org\/10.1161\/01.RES.0000109416.56608.64","journal-title":"Circ Res"},{"key":"908_CR51","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/0891-5849(92)90176-h","volume":"13","author":"T Paraidathathu","year":"1992","unstructured":"Paraidathathu T, de Groot H, Kehrer JP (1992) Production of reactive oxygen by mitochondria from normoxic and hypoxic rat heart tissue. Free Radic Biol Med 13:289\u2013297. https:\/\/doi.org\/10.1016\/0891-5849(92)90176-h","journal-title":"Free Radic Biol Med"},{"key":"908_CR52","doi-asserted-by":"publisher","first-page":"805","DOI":"10.2353\/ajpath.2007.061243","volume":"170","author":"P Patwari","year":"2007","unstructured":"Patwari P, Lee RT (2007) Thioredoxins, mitochondria, and hypertension. Am J Pathol 170:805\u2013808. https:\/\/doi.org\/10.2353\/ajpath.2007.061243","journal-title":"Am J Pathol"},{"key":"908_CR53","doi-asserted-by":"publisher","first-page":"C369","DOI":"10.1152\/ajpcell.1990.258.2.C369","volume":"258","author":"RJ Paul","year":"1990","unstructured":"Paul RJ (1990) Smooth muscle energetics and theories of cross-bridge regulation. Am J Physiol 258:C369-375. https:\/\/doi.org\/10.1152\/ajpcell.1990.258.2.C369","journal-title":"Am J Physiol"},{"key":"908_CR54","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1161\/01.RES.0000229685.37402.80","volume":"99","author":"A Picchi","year":"2006","unstructured":"Picchi A, Gao X, Belmadani S, Potter BJ, Focardi M, Chilian WM, Zhang C (2006) Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 99:69\u201377. https:\/\/doi.org\/10.1161\/01.RES.0000229685.37402.80","journal-title":"Circ Res"},{"key":"908_CR55","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1161\/01.CIR.83.3.1118","volume":"83","author":"GM Rubanyi","year":"1991","unstructured":"Rubanyi GM (1991) Reversal of hypercholesterolemia-induced endothelial dysfunction by L-arginine. Circulaiton 83:1118\u20131120","journal-title":"Circulaiton"},{"key":"908_CR56","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1089\/ars.2007.1989","volume":"10","author":"E Schulz","year":"2008","unstructured":"Schulz E, Jansen T, Wenzel P, Daiber A, Munzel T (2008) Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. Antioxid Redox Signal 10:1115\u20131126. https:\/\/doi.org\/10.1089\/ars.2007.1989","journal-title":"Antioxid Redox Signal"},{"key":"908_CR57","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.dnarep.2004.11.009","volume":"4","author":"IN Shokolenko","year":"2005","unstructured":"Shokolenko IN, Alexeyev MF, LeDoux SP, Wilson GL (2005) TAT-mediated protein transduction and targeted delivery of fusion proteins into mitochondria of breast cancer cells. DNA Repair (Amst) 4:511\u2013518. https:\/\/doi.org\/10.1016\/j.dnarep.2004.11.009","journal-title":"DNA Repair (Amst)"},{"key":"908_CR58","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1527-5299.2002.00717.x","volume":"8","author":"D Sorescu","year":"2002","unstructured":"Sorescu D, Griendling KK (2002) Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure. Congest Heart Fail 8:132\u2013140. https:\/\/doi.org\/10.1111\/j.1527-5299.2002.00717.x","journal-title":"Congest Heart Fail"},{"key":"908_CR59","doi-asserted-by":"publisher","first-page":"L639","DOI":"10.1152\/ajplung.00396.2018","volume":"317","author":"K Suresh","year":"2019","unstructured":"Suresh K, Servinsky L, Jiang H, Bigham Z, Zaldumbide J, Huetsch JC, Kliment C, Acoba MG, Kirsch BJ, Claypool SM, Le A, Damarla M, Shimoda LA (2019) Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416\/hypoxia model of pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 317:L639\u2013L652. https:\/\/doi.org\/10.1152\/ajplung.00396.2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"908_CR60","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1161\/01.cir.98.1.9","volume":"98","author":"CP Tiefenbacher","year":"1998","unstructured":"Tiefenbacher CP, DeFily DV, Chilian WM (1998) Requisite role of cardiac myocytes in coronary alpha1-adrenergic constriction. Circulation 98:9\u201312. https:\/\/doi.org\/10.1161\/01.cir.98.1.9","journal-title":"Circulation"},{"key":"908_CR61","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1084\/jem.192.12.1731","volume":"192","author":"B van der Loo","year":"2000","unstructured":"van der Loo B, Labugger R, Skepper JN, Bachschmid M, Kilo J, Powell JM, Palacios-Callender M, Erusalimsky JD, Quaschning T, Malinski T, Gygi D, Ullrich V, Luscher TF (2000) Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med 192:1731\u20131744. https:\/\/doi.org\/10.1084\/jem.192.12.1731","journal-title":"J Exp Med"},{"key":"908_CR62","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1016\/S0140-6736(03)13637-9","volume":"361","author":"DP Vivekananthan","year":"2003","unstructured":"Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ (2003) Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 361:2017\u20132023. https:\/\/doi.org\/10.1016\/S0140-6736(03)13637-9","journal-title":"Lancet"},{"key":"908_CR63","doi-asserted-by":"publisher","first-page":"13898","DOI":"10.1038\/s41598-019-48383-y","volume":"9","author":"TW Weinrich","year":"2019","unstructured":"Weinrich TW, Kam JH, Ferrara BT, Thompson EP, Mitrofanis J, Jeffery G (2019) A day in the life of mitochondria reveals shifting workloads. Sci Rep 9:13898. https:\/\/doi.org\/10.1038\/s41598-019-48383-y","journal-title":"Sci Rep"},{"key":"908_CR64","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1161\/CIRCRESAHA.108.178467","volume":"104","author":"JY Youn","year":"2009","unstructured":"Youn JY, Wang T, Cai H (2009) An ezrin\/calpain\/PI3K\/AMPK\/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production. Circ Res 104:50\u201359. https:\/\/doi.org\/10.1161\/CIRCRESAHA.108.178467","journal-title":"Circ Res"},{"key":"908_CR65","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1161\/hy1201.099611","volume":"38","author":"G Zalba","year":"2001","unstructured":"Zalba G, San Jose G, Moreno MU, Fortuno MA, Fortuno A, Beaumont FJ, Diez J (2001) Oxidative stress in arterial hypertension: role of NAD(P)H oxidase. Hypertension 38:1395\u20131399. https:\/\/doi.org\/10.1161\/hy1201.099611","journal-title":"Hypertension"},{"key":"908_CR66","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1161\/01.ATV.0000201932.32678.7e","volume":"26","author":"C Zhang","year":"2006","unstructured":"Zhang C, Xu X, Potter BJ, Wang W, Kuo L, Michael L, Bagby GJ, Chilian WM (2006) TNF-alpha contributes to endothelial dysfunction in ischemia\/reperfusion injury. Arterioscler Thromb Vasc Biol 26:475\u2013480. https:\/\/doi.org\/10.1161\/01.ATV.0000201932.32678.7e","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"908_CR67","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1161\/01.ATV.0000221230.08596.98","volume":"26","author":"Y Zhang","year":"2006","unstructured":"Zhang Y, Lee TS, Kolb EM, Sun K, Lu X, Sladek FM, Kassab GS, Garland T Jr, Shyy JY (2006) AMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stress. Arterioscler Thromb Vasc Biol 26:1281\u20131287. https:\/\/doi.org\/10.1161\/01.ATV.0000221230.08596.98","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"908_CR68","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00395-018-0682-1","volume":"113","author":"H Zhou","year":"2018","unstructured":"Zhou H, Wang J, Zhu P, Zhu H, Toan S, Hu S, Ren J, Chen Y (2018) NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2alpha. Basic Res Cardiol 113:23. https:\/\/doi.org\/10.1007\/s00395-018-0682-1","journal-title":"Basic Res Cardiol"},{"key":"908_CR69","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092753","author":"N Zippel","year":"2018","unstructured":"Zippel N, Loot AE, Stingl H, Randriamboavonjy V, Fleming I, Fisslthaler B (2018) Endothelial AMP-Activated Kinase alpha1 Phosphorylates eNOS on Thr495 and Decreases Endothelial NO Formation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms19092753","journal-title":"Int J Mol Sci"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-021-00908-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-021-00908-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-021-00908-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T12:06:06Z","timestamp":1675080366000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-021-00908-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["908"],"URL":"https:\/\/doi.org\/10.1007\/s00395-021-00908-1","relation":{},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]},"assertion":[{"value":"7 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr. Wilson has an interest in Exscien, which supplied the recombinant proteins, mt-tat-EndoIII and mt-tat-ExoIII. There are no other disclosures or conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experiments were approved by the Institutional Animal Care and Use Committee. The manuscript does not contain clinical studies or patient data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All the authors consent to publication and approve of this version of the paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"3"}}