{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:41:38Z","timestamp":1791308498945,"version":"4.3.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["10\/14"],"award-info":[{"award-number":["10\/14"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Seymour Fefer Foundation"},{"name":"Scholarship from Mrs. Tuna Gursoy"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00395-022-00957-0","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T10:02:56Z","timestamp":1665741776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Osteopontin promotes infarct repair"],"prefix":"10.1007","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4541-2127","authenticated-orcid":false,"given":"Itai","family":"Rotem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Konfino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Caller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeshai","family":"Schary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Shaihov-Teper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahlia","family":"Palevski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Lendengolts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nili","family":"Naftali-Shani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2113-2128","authenticated-orcid":false,"given":"Jonathan","family":"Leor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"957_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12974-014-0197-0","volume":"11","author":"AM Albertsson","year":"2014","unstructured":"Albertsson AM, Zhang X, Leavenworth J, Bi D, Nair S, Qiao L, Hagberg H, Mallard C, Cantor H, Wang X (2014) The effect of osteopontin and osteopontin-derived peptides on preterm brain injury. J Neuroinflammation 11:197. https:\/\/doi.org\/10.1186\/s12974-014-0197-0","journal-title":"J Neuroinflammation"},{"key":"957_CR2","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1172\/JCI72181","volume":"124","author":"AB Aurora","year":"2014","unstructured":"Aurora AB, Porrello ER, Tan W, Mahmoud AI, Hill JA, Bassel-Duby R, Sadek HA, Olson EN (2014) Macrophages are required for neonatal heart regeneration. J Clin Invest 124:1382\u20131392. https:\/\/doi.org\/10.1172\/JCI72181","journal-title":"J Clin Invest"},{"key":"957_CR3","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1161\/CIRCULATIONAHA.119.045116","volume":"142","author":"A Baehr","year":"2020","unstructured":"Baehr A, Umansky KB, Bassat E, Jurisch V, Klett K, Bozoglu T, Hornaschewitz N, Solyanik O, Kain D, Ferraro B, Cohen-Rabi R, Krane M, Cyran C, Soehnlein O, Laugwitz KL, Hinkel R, Kupatt C, Tzahor E (2020) Agrin promotes coordinated therapeutic processes leading to improved cardiac repair in pigs. Circulation 142:868\u2013881. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.045116","journal-title":"Circulation"},{"key":"957_CR4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature22978","volume":"547","author":"E Bassat","year":"2017","unstructured":"Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Riabov Bassat D, Udi Y, Sarig R, Sagi I, Martin JF, Bursac N, Cohen S, Tzahor E (2017) The extracellular matrix protein agrin promotes heart regeneration in mice. Nature 547:179\u2013184. https:\/\/doi.org\/10.1038\/nature22978","journal-title":"Nature"},{"key":"957_CR5","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1161\/CIRCRESAHA.110.239574","volume":"108","author":"M Bauer","year":"2011","unstructured":"Bauer M, Cheng S, Jain M, Ngoy S, Theodoropoulos C, Trujillo A, Lin FC, Liao R (2011) Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice. Circ Res 108:908\u2013916. https:\/\/doi.org\/10.1161\/CIRCRESAHA.110.239574","journal-title":"Circ Res"},{"key":"957_CR6","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/j.jacc.2013.07.057","volume":"62","author":"T Ben-Mordechai","year":"2013","unstructured":"Ben-Mordechai T, Holbova R, Landa-Rouben N, Harel-Adar T, Feinberg MS, Abd Elrahman I, Blum G, Epstein FH, Silman Z, Cohen S, Leor J (2013) Macrophage subpopulations are essential for infarct repair with and without stem cell therapy. J Am Coll Cardiol 62:1890\u20131901. https:\/\/doi.org\/10.1016\/j.jacc.2013.07.057","journal-title":"J Am Coll Cardiol"},{"key":"957_CR7","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/j.cell.2015.05.026","volume":"161","author":"O Bergmann","year":"2015","unstructured":"Bergmann O, Zdunek S, Felker A, Salehpour M, Alkass K, Bernard S, Sjostrom SL, Szewczykowska M, Jackowska T, Dos Remedios C, Malm T, Andra M, Jashari R, Nyengaard JR, Possnert G, Jovinge S, Druid H, Frisen J (2015) Dynamics of cell generation and turnover in the human heart. Cell 161:1566\u20131575. https:\/\/doi.org\/10.1016\/j.cell.2015.05.026","journal-title":"Cell"},{"key":"957_CR8","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/S0022-5223(97)70260-5","volume":"113","author":"CJ Blewett","year":"1997","unstructured":"Blewett CJ, Cilley RE, Ehrlich HP, Blackburn JH 2nd, Dillon PW, Krummel TM (1997) Regenerative healing of incisional wounds in midgestational murine hearts in organ culture. J Thorac Cardiovasc Surg 113:880\u2013885. https:\/\/doi.org\/10.1016\/S0022-5223(97)70260-5","journal-title":"J Thorac Cardiovasc Surg"},{"key":"957_CR9","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1161\/STROKEAHA.110.599118","volume":"42","author":"W Chen","year":"2011","unstructured":"Chen W, Ma Q, Suzuki H, Hartman R, Tang J, Zhang JH (2011) Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model. Stroke 42:764\u2013769. https:\/\/doi.org\/10.1161\/STROKEAHA.110.599118","journal-title":"Stroke"},{"key":"957_CR10","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1038\/onc.2009.189","volume":"28","author":"J Dai","year":"2009","unstructured":"Dai J, Peng L, Fan K, Wang H, Wei R, Ji G, Cai J, Lu B, Li B, Zhang D, Kang Y, Tan M, Qian W, Guo Y (2009) Osteopontin induces angiogenesis through activation of PI3K\/AKT and ERK1\/2 in endothelial cells. Oncogene 28:3412\u20133422. https:\/\/doi.org\/10.1038\/onc.2009.189","journal-title":"Oncogene"},{"key":"957_CR11","doi-asserted-by":"publisher","first-page":"952","DOI":"10.2353\/ajpath.2010.090622","volume":"176","author":"L Deng","year":"2010","unstructured":"Deng L, Zhou JF, Sellers RS, Li JF, Nguyen AV, Wang Y, Orlofsky A, Liu Q, Hume DA, Pollard JW, Augenlicht L, Lin EY (2010) A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. Am J Pathol 176:952\u2013967. https:\/\/doi.org\/10.2353\/ajpath.2010.090622","journal-title":"Am J Pathol"},{"key":"957_CR12","doi-asserted-by":"publisher","DOI":"10.3791\/50154","volume":"79","author":"E Ehler","year":"2013","unstructured":"Ehler E, Moore-Morris T, Lange S (2013) Isolation and culture of neonatal mouse cardiomyocytes. J Vis Exp JoVE 79: e50154. https:\/\/doi.org\/10.3791\/50154","journal-title":"J Vis Exp JoVE"},{"key":"957_CR13","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.immuni.2013.11.019","volume":"40","author":"S Epelman","year":"2014","unstructured":"Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsberg EC, Yokoyama WM, Unanue ER, Colonna M, Randolph GJ, Mann DL (2014) Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. Immunity 40:91\u2013104. https:\/\/doi.org\/10.1016\/j.immuni.2013.11.019","journal-title":"Immunity"},{"key":"957_CR14","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1161\/CIRCULATIONAHA.117.029343","volume":"136","author":"T Eschenhagen","year":"2017","unstructured":"Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisen J, Giacca M, Hare JM, Houser S, Lee RT, Marban E, Martin JF, Molkentin JD, Murry CE, Riley PR, Ruiz-Lozano P, Sadek HA, Sussman MA, Hill JA (2017) Cardiomyocyte regeneration: a consensus statement. Circulation 136:680\u2013686. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.029343","journal-title":"Circulation"},{"key":"957_CR15","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1161\/CIRCRESAHA.119.311148","volume":"125","author":"NG Frangogiannis","year":"2019","unstructured":"Frangogiannis NG (2019) The extracellular matrix in ischemic and nonischemic heart failure. Circ Res 125:117\u2013146. https:\/\/doi.org\/10.1161\/CIRCRESAHA.119.311148","journal-title":"Circ Res"},{"key":"957_CR16","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1161\/01.cir.96.9.3063","volume":"96","author":"K Graf","year":"1997","unstructured":"Graf K, Do YS, Ashizawa N, Meehan WP, Giachelli CM, Marboe CC, Fleck E, Hsueh WA (1997) Myocardial osteopontin expression is associated with left ventricular hypertrophy. Circulation 96:3063\u20133071. https:\/\/doi.org\/10.1161\/01.cir.96.9.3063","journal-title":"Circulation"},{"key":"957_CR17","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s00395-016-0580-3","volume":"111","author":"BJ Haubner","year":"2016","unstructured":"Haubner BJ, Schuetz T, Penninger JM (2016) A reproducible protocol for neonatal ischemic injury and cardiac regeneration in neonatal mice. Basic Res Cardiol 111:64. https:\/\/doi.org\/10.1007\/s00395-016-0580-3","journal-title":"Basic Res Cardiol"},{"key":"957_CR18","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1161\/CIRCULATIONAHA.119.045566","volume":"142","author":"L He","year":"2020","unstructured":"He L, Nguyen NB, Ardehali R, Zhou B (2020) Heart regeneration by endogenous stem cells and cardiomyocyte proliferation: controversy, fallacy, and progress. Circulation 142:275\u2013291. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.045566","journal-title":"Circulation"},{"key":"957_CR19","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1245\/s10434-010-0927-1","volume":"17","author":"KH Hsu","year":"2010","unstructured":"Hsu KH, Tsai HW, Lin PW, Hsu YS, Shan YS, Lu PJ (2010) Clinical implication and mitotic effect of CD44 cleavage in relation to osteopontin\/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor. Ann Surg Oncol 17:2199\u20132212. https:\/\/doi.org\/10.1245\/s10434-010-0927-1","journal-title":"Ann Surg Oncol"},{"key":"957_CR20","doi-asserted-by":"publisher","first-page":"4133","DOI":"10.1242\/dev.079756","volume":"139","author":"J Itou","year":"2012","unstructured":"Itou J, Oishi I, Kawakami H, Glass TJ, Richter J, Johnson A, Lund TC, Kawakami Y (2012) Migration of cardiomyocytes is essential for heart regeneration in zebrafish. Development 139:4133\u20134142. https:\/\/doi.org\/10.1242\/dev.079756","journal-title":"Development"},{"key":"957_CR21","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/s41590-020-0741-2","volume":"21","author":"V Koliaraki","year":"2020","unstructured":"Koliaraki V, Prados A, Armaka M, Kollias G (2020) The mesenchymal context in inflammation, immunity and cancer. Nat Immunol 21:974\u2013982. https:\/\/doi.org\/10.1038\/s41590-020-0741-2","journal-title":"Nat Immunol"},{"key":"957_CR22","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001320","volume":"4","author":"T Konfino","year":"2015","unstructured":"Konfino T, Landa N, Ben-Mordechai T, Leor J (2015) The type of injury dictates the mode of repair in neonatal and adult heart. J Am Heart Assoc 4:e001320. https:\/\/doi.org\/10.1161\/JAHA.114.001320","journal-title":"J Am Heart Assoc"},{"key":"957_CR23","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/nm1619","volume":"13","author":"B Kuhn","year":"2007","unstructured":"Kuhn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT (2007) Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat Med 13:962\u2013969. https:\/\/doi.org\/10.1038\/nm1619","journal-title":"Nat Med"},{"key":"957_CR24","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/j.ajpath.2016.01.002","volume":"186","author":"M Kuraoka","year":"2016","unstructured":"Kuraoka M, Kimura E, Nagata T, Okada T, Aoki Y, Tachimori H, Yonemoto N, Imamura M, Si T (2016) Serum osteopontin as a novel biomarker for muscle regeneration in duchenne muscular dystrophy. Am J Pathol 186:1302\u20131312. https:\/\/doi.org\/10.1016\/j.ajpath.2016.01.002","journal-title":"Am J Pathol"},{"key":"957_CR25","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1161\/CIRCULATIONAHA.107.727420","volume":"117","author":"N Landa","year":"2008","unstructured":"Landa N, Miller L, Feinberg MS, Holbova R, Shachar M, Freeman I, Cohen S, Leor J (2008) Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat. Circulation 117:1388\u20131396. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.727420","journal-title":"Circulation"},{"key":"957_CR26","doi-asserted-by":"publisher","first-page":"16029","DOI":"10.1073\/pnas.1406508111","volume":"111","author":"KJ Lavine","year":"2014","unstructured":"Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, Ornitz DM, Randolph GJ, Mann DL (2014) Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. Proc Natl Acad Sci U S A 111:16029\u201316034. https:\/\/doi.org\/10.1073\/pnas.1406508111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"957_CR27","doi-asserted-by":"publisher","first-page":"H1237","DOI":"10.1152\/ajpheart.00559.2015","volume":"309","author":"M Leone","year":"2015","unstructured":"Leone M, Magadum A, Engel FB (2015) Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations. Am J Physiol Heart Circ Physiol 309:H1237-1250. https:\/\/doi.org\/10.1152\/ajpheart.00559.2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"957_CR28","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nprot.2007.30","volume":"2","author":"CC Liang","year":"2007","unstructured":"Liang CC, Park AY, Guan JL (2007) In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2:329\u2013333. https:\/\/doi.org\/10.1038\/nprot.2007.30","journal-title":"Nat Protoc"},{"key":"957_CR29","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1161\/ATVBAHA.118.311577","volume":"39","author":"ZSY Lok","year":"2019","unstructured":"Lok ZSY, Lyle AN (2019) Osteopontin in vascular disease. Arterioscler Thromb Vasc Biol 39:613\u2013622. https:\/\/doi.org\/10.1161\/ATVBAHA.118.311577","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"957_CR30","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/nprot.2014.021","volume":"9","author":"AI Mahmoud","year":"2014","unstructured":"Mahmoud AI, Porrello ER, Kimura W, Olson EN, Sadek HA (2014) Surgical models for cardiac regeneration in neonatal mice. Nat Protoc 9:305\u2013311. https:\/\/doi.org\/10.1038\/nprot.2014.021","journal-title":"Nat Protoc"},{"key":"957_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110058","volume":"37","author":"SM Millard","year":"2021","unstructured":"Millard SM, Heng O, Opperman KS, Sehgal A, Irvine KM, Kaur S, Sandrock CJ, Wu AC, Magor GW, Batoon L, Perkins AC, Noll JE, Zannettino ACW, Sester DP, Levesque JP, Hume DA, Raggatt LJ, Summers KM, Pettit AR (2021) Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Rep 37:110058. https:\/\/doi.org\/10.1016\/j.celrep.2021.110058","journal-title":"Cell Rep"},{"issue":"104\u2013116","key":"957_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.014","volume":"173","author":"TMA Mohamed","year":"2018","unstructured":"Mohamed TMA, Ang YS, Radzinsky E, Zhou P, Huang Y, Elfenbein A, Foley A, Magnitsky S, Srivastava D (2018) Regulation of cell cycle to stimulate adult cardiomyocyte proliferation and cardiac regeneration. Cell 173(104\u2013116):e112. https:\/\/doi.org\/10.1016\/j.cell.2018.02.014","journal-title":"Cell"},{"key":"957_CR33","first-page":"1450","volume":"145","author":"CE Murry","year":"1994","unstructured":"Murry CE, Giachelli CM, Schwartz SM, Vracko R (1994) Macrophages express osteopontin during repair of myocardial necrosis. Am J Pathol 145:1450\u20131462","journal-title":"Am J Pathol"},{"key":"957_CR34","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/dvg.20335","volume":"45","author":"MD Muzumdar","year":"2007","unstructured":"Muzumdar MD, Tasic B, Miyamichi K, Li L, Luo L (2007) A global double-fluorescent Cre reporter mouse. Genesis 45:593\u2013605. https:\/\/doi.org\/10.1002\/dvg.20335","journal-title":"Genesis"},{"key":"957_CR35","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1161\/CIRCULATIONAHA.116.023527","volume":"135","author":"N Naftali-Shani","year":"2017","unstructured":"Naftali-Shani N, Levin-Kotler LP, Palevski D, Amit U, Kain D, Landa N, Hochhauser E, Leor J (2017) Left ventricular dysfunction switches mesenchymal stromal cells toward an inflammatory phenotype and impairs their reparative properties via toll-like receptor-4. Circulation 135:2271\u20132287. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.023527","journal-title":"Circulation"},{"key":"957_CR36","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12865-019-0314-z","volume":"20","author":"K Ogawa","year":"2019","unstructured":"Ogawa K, Tsurutani M, Hashimoto A, Soeda M (2019) Simple propagation method for resident macrophages by co-culture and subculture, and their isolation from various organs. BMC Immunol 20:34. https:\/\/doi.org\/10.1186\/s12865-019-0314-z","journal-title":"BMC Immunol"},{"key":"957_CR37","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004387","author":"D Palevski","year":"2017","unstructured":"Palevski D, Levin-Kotler LP, Kain D, Naftali-Shani N, Landa N, Ben-Mordechai T, Konfino T, Holbova R, Molotski N, Rosin-Arbesfeld R, Lang RA, Leor J (2017) Loss of macrophage wnt secretion improves remodeling and function after myocardial infarction in mice. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.116.004387","journal-title":"J Am Heart Assoc"},{"key":"957_CR38","doi-asserted-by":"publisher","first-page":"553","DOI":"10.18632\/aging.100477","volume":"4","author":"P Paliwal","year":"2012","unstructured":"Paliwal P, Pishesha N, Wijaya D, Conboy IM (2012) Age dependent increase in the levels of osteopontin inhibits skeletal muscle regeneration. Aging (Albany NY) 4:553\u2013566. https:\/\/doi.org\/10.18632\/aging.100477","journal-title":"Aging (Albany NY)"},{"key":"957_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2020.112902","volume":"487","author":"G Pfister","year":"2020","unstructured":"Pfister G, Toor SM, Sasidharan Nair V, Elkord E (2020) An evaluation of sorter induced cell stress (SICS) on peripheral blood mononuclear cells (PBMCs) after different sort conditions\u2014are your sorted cells getting SICS? J Immunol Methods 487:112902. https:\/\/doi.org\/10.1016\/j.jim.2020.112902","journal-title":"J Immunol Methods"},{"key":"957_CR40","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/0031-9384(86)90058-2","volume":"38","author":"CB Phifer","year":"1986","unstructured":"Phifer CB, Terry LM (1986) Use of hypothermia for general anesthesia in preweanling rodents. Physiol Behav 38:887\u2013890","journal-title":"Physiol Behav"},{"key":"957_CR41","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/78\/1\/016601","volume":"78","author":"BD Plouffe","year":"2015","unstructured":"Plouffe BD, Murthy SK, Lewis LH (2015) Fundamentals and application of magnetic particles in cell isolation and enrichment: a review. Rep Prog Phys 78:016601. https:\/\/doi.org\/10.1088\/0034-4885\/78\/1\/016601","journal-title":"Rep Prog Phys"},{"key":"957_CR42","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1200708","volume":"331","author":"ER Porrello","year":"2011","unstructured":"Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, Olson EN, Sadek HA (2011) Transient regenerative potential of the neonatal mouse heart. Science 331:1078\u20131080. https:\/\/doi.org\/10.1126\/science.1200708","journal-title":"Science"},{"key":"957_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13256","author":"TJ Povsic","year":"2021","unstructured":"Povsic TJ, Sanz-Ruiz R, Climent AM, Bolli R, Taylor DA, Gersh BJ, Menasche P, Perin EC, Pompilio G, Atsma DE, Badimon L, DeMaria AN, Hare JM, Henry TD, Janssens S, Kastrup J, Torella D, Traverse JH, Willerson JT, Fernandez-Aviles F (2021) Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies. ESC Heart Fail. https:\/\/doi.org\/10.1002\/ehf2.13256","journal-title":"ESC Heart Fail"},{"key":"957_CR44","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.stem.2019.12.004","volume":"26","author":"H Sadek","year":"2020","unstructured":"Sadek H, Olson EN (2020) Toward the goal of human heart regeneration. Cell Stem Cell 26:7\u201316. https:\/\/doi.org\/10.1016\/j.stem.2019.12.004","journal-title":"Cell Stem Cell"},{"key":"957_CR45","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00395-020-00836-6","volume":"115","author":"M Sansonetti","year":"2020","unstructured":"Sansonetti M, Waleczek FJG, Jung M, Thum T, Perbellini F (2020) Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology. Basic Res Cardiol 115:77. https:\/\/doi.org\/10.1007\/s00395-020-00836-6","journal-title":"Basic Res Cardiol"},{"key":"957_CR46","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1161\/CIRCULATIONAHA.117.031358","volume":"138","author":"D Sawaki","year":"2018","unstructured":"Sawaki D, Czibik G, Pini M, Ternacle J, Suffee N, Mercedes R, Marcelin G, Surenaud M, Marcos E, Gual P, Clement K, Hue S, Adnot S, Hatem SN, Tsuchimochi I, Yoshimitsu T, Henegar C, Derumeaux G (2018) Visceral adipose tissue drives cardiac aging through modulation of fibroblast senescence by osteopontin production. Circulation 138:809\u2013822. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.031358","journal-title":"Circulation"},{"key":"957_CR47","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/cvr\/cvaa320","volume":"117","author":"JR Sayers","year":"2021","unstructured":"Sayers JR, Riley PR (2021) Heart regeneration: beyond new muscle and vessels. Cardiovasc Res 117:727\u2013742. https:\/\/doi.org\/10.1093\/cvr\/cvaa320","journal-title":"Cardiovasc Res"},{"key":"957_CR48","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez JY, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676\u2013682. https:\/\/doi.org\/10.1038\/nmeth.2019","journal-title":"Nat Methods"},{"key":"957_CR49","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider CA, Rasband WS, Eliceiri KW (2012) NIH image to ImageJ: 25 years of image analysis. Nat Methods 9:671\u2013675. https:\/\/doi.org\/10.1038\/nmeth.2089","journal-title":"Nat Methods"},{"key":"957_CR50","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1158\/0008-5472.Can-14-1990","volume":"75","author":"Y Sharon","year":"2015","unstructured":"Sharon Y, Raz Y, Cohen N, Ben-Shmuel A, Schwartz H, Geiger T, Erez N (2015) Tumor-derived osteopontin reprograms normal mammary fibroblasts to promote inflammation and tumor growth in breast cancer. Cancer Res 75:963\u2013973. https:\/\/doi.org\/10.1158\/0008-5472.Can-14-1990","journal-title":"Cancer Res"},{"key":"957_CR51","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017071","volume":"9","author":"K Shirakawa","year":"2020","unstructured":"Shirakawa K, Endo J, Kataoka M, Katsumata Y, Anzai A, Moriyama H, Kitakata H, Hiraide T, Ko S, Goto S, Ichihara G, Fukuda K, Minamino T, Sano M (2020) MerTK expression and ERK activation are essential for the functional maturation of osteopontin-producing reparative macrophages after myocardial infarction. J Am Heart Assoc 9:e017071. https:\/\/doi.org\/10.1161\/JAHA.120.017071","journal-title":"J Am Heart Assoc"},{"key":"957_CR52","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1161\/CIRCULATIONAHA.118.035047","volume":"138","author":"K Shirakawa","year":"2018","unstructured":"Shirakawa K, Endo J, Kataoka M, Katsumata Y, Yoshida N, Yamamoto T, Isobe S, Moriyama H, Goto S, Kitakata H, Hiraide T, Fukuda K, Sano M (2018) IL (Interleukin)-10-STAT3-galectin-3 axis is essential for osteopontin-producing reparative macrophage polarization after myocardial infarction. Circulation 138:2021\u20132035. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.035047","journal-title":"Circulation"},{"key":"957_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/biom11071047","author":"K Shirakawa","year":"2021","unstructured":"Shirakawa K, Sano M (2021) Osteopontin in cardiovascular diseases. Biomolecules. https:\/\/doi.org\/10.3390\/biom11071047","journal-title":"Biomolecules"},{"key":"957_CR54","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1161\/01.HYP.33.2.663","volume":"33","author":"K Singh","year":"1999","unstructured":"Singh K, Sirokman G, Communal C, Robinson KG, Conrad CH, Brooks WW, Bing OH, Colucci WS (1999) Myocardial osteopontin expression coincides with the development of heart failure. Hypertension 33:663\u2013670","journal-title":"Hypertension"},{"key":"957_CR55","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.yjmcc.2009.06.015","volume":"48","author":"M Singh","year":"2010","unstructured":"Singh M, Foster CR, Dalal S, Singh K (2010) Osteopontin: role in extracellular matrix deposition and myocardial remodeling post-MI. J Mol Cell Cardiol 48:538\u2013543. https:\/\/doi.org\/10.1016\/j.yjmcc.2009.06.015","journal-title":"J Mol Cell Cardiol"},{"key":"957_CR56","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1097\/CCM.0b013e3181c027ae","volume":"38","author":"H Suzuki","year":"2010","unstructured":"Suzuki H, Ayer R, Sugawara T, Chen W, Sozen T, Hasegawa Y, Kanamaru K, Zhang JH (2010) Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats. Crit Care Med 38:612\u2013618. https:\/\/doi.org\/10.1097\/CCM.0b013e3181c027ae","journal-title":"Crit Care Med"},{"key":"957_CR57","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1161\/hh1001.090842","volume":"88","author":"NA Trueblood","year":"2001","unstructured":"Trueblood NA, Xie Z, Communal C, Sam F, Ngoy S, Liaw L, Jenkins AW, Wang J, Sawyer DB, Bing OH, Apstein CS, Colucci WS, Singh K (2001) Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin. Circ Res 88:1080\u20131087. https:\/\/doi.org\/10.1161\/hh1001.090842","journal-title":"Circ Res"},{"key":"957_CR58","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1126\/science.aam5894","volume":"356","author":"E Tzahor","year":"2017","unstructured":"Tzahor E, Poss KD (2017) Cardiac regeneration strategies: staying young at heart. Science 356:1035\u20131039. https:\/\/doi.org\/10.1126\/science.aam5894","journal-title":"Science"},{"key":"957_CR59","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13395-019-0190-5","volume":"9","author":"DK Wasgewatte Wijesinghe","year":"2019","unstructured":"Wasgewatte Wijesinghe DK, Mackie EJ, Pagel CN (2019) Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells. Skelet Muscle 9:6. https:\/\/doi.org\/10.1186\/s13395-019-0190-5","journal-title":"Skelet Muscle"},{"key":"957_CR60","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1172\/jci124615","volume":"129","author":"S Watanabe","year":"2019","unstructured":"Watanabe S, Alexander M, Misharin AV, Budinger GRS (2019) The role of macrophages in the resolution of inflammation. J Clin Invest 129:2619\u20132628. https:\/\/doi.org\/10.1172\/jci124615","journal-title":"J Clin Invest"},{"key":"957_CR61","doi-asserted-by":"publisher","first-page":"513","DOI":"10.2217\/bmm-2019-0410","volume":"14","author":"A Weber","year":"2020","unstructured":"Weber A, B\u00fcttner AL, Rellecke P, Petrov G, Albert A, Sixt SU, Lichtenberg A, Akhyari P (2020) Osteopontin as novel biomarker for reversibility of pressure overload induced left ventricular hypertrophy. Biomark Med 14:513\u2013523. https:\/\/doi.org\/10.2217\/bmm-2019-0410","journal-title":"Biomark Med"},{"key":"957_CR62","doi-asserted-by":"publisher","first-page":"H24","DOI":"10.1152\/ajpheart.00521.2018","volume":"316","author":"DJ Wodsedalek","year":"2019","unstructured":"Wodsedalek DJ, Paddock SJ, Wan TC, Auchampach JA, Kenarsary A, Tsaih SW, Flister MJ, O\u2019Meara CC (2019) IL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration. Am J Physiol Heart Circ Physiol 316:H24\u2013H34. https:\/\/doi.org\/10.1152\/ajpheart.00521.2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"957_CR63","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1161\/CIRCRESAHA.119.316303","volume":"127","author":"CC Wu","year":"2020","unstructured":"Wu CC, Jeratsch S, Graumann J, Stainier DYR (2020) Modulation of mammalian cardiomyocyte cytokinesis by the extracellular matrix. Circ Res 127:896\u2013907. https:\/\/doi.org\/10.1161\/CIRCRESAHA.119.316303","journal-title":"Circ Res"},{"key":"957_CR64","doi-asserted-by":"publisher","first-page":"13839","DOI":"10.1073\/pnas.1313192110","volume":"110","author":"M Xin","year":"2013","unstructured":"Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, Porrello ER, Mahmoud AI, Tan W, Shelton JM, Richardson JA, Sadek HA, Bassel-Duby R, Olson EN (2013) Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A 110:13839\u201313844. https:\/\/doi.org\/10.1073\/pnas.1313192110","journal-title":"Proc Natl Acad Sci U S A"},{"key":"957_CR65","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1016\/j.jacc.2019.02.074","volume":"73","author":"K Yousefi","year":"2019","unstructured":"Yousefi K, Irion CI, Takeuchi LM, Ding W, Lambert G, Eisenberg T, Sukkar S, Granzier HL, Methawasin M, Lee DI, Hahn VS, Kass DA, Hatzistergos KE, Hare JM, Webster KA, Shehadeh LA (2019) Osteopontin promotes left ventricular diastolic dysfunction through a mitochondrial pathway. J Am Coll Cardiol 73:2705\u20132718. https:\/\/doi.org\/10.1016\/j.jacc.2019.02.074","journal-title":"J Am Coll Cardiol"},{"key":"957_CR66","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1016\/j.cellsig.2014.07.031","volume":"26","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Xia H, Ge X, Chen Q, Yuan D, Chen Q, Leng W, Chen L, Tang Q, Bi F (2014) CD44 acts through RhoA to regulate YAP signaling. Cell Signal 26:2504\u20132513. https:\/\/doi.org\/10.1016\/j.cellsig.2014.07.031","journal-title":"Cell Signal"},{"key":"957_CR67","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/ncb2303","volume":"13","author":"B Zhao","year":"2011","unstructured":"Zhao B, Tumaneng K, Guan KL (2011) The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol 13:877\u2013883. https:\/\/doi.org\/10.1038\/ncb2303","journal-title":"Nat Cell Biol"},{"key":"957_CR68","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1161\/CIRCRESAHA.116.303311","volume":"116","author":"Q Zhou","year":"2015","unstructured":"Zhou Q, Li L, Zhao B, Guan KL (2015) The hippo pathway in heart development, regeneration, and diseases. Circ Res 116:1431\u20131447. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.303311","journal-title":"Circ Res"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-022-00957-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-022-00957-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-022-00957-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T12:11:00Z","timestamp":1675080660000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-022-00957-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,14]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["957"],"URL":"https:\/\/doi.org\/10.1007\/s00395-022-00957-0","relation":{},"ISSN":["0300-8428","1435-1803"],"issn-type":[{"value":"0300-8428","type":"print"},{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,14]]},"assertion":[{"value":"30 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental protocols were approved by the Ethical Committees of the Sheba Medical Center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"51"}}