{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:36:44Z","timestamp":1793824604066,"version":"4.6.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870207"],"award-info":[{"award-number":["81870207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270470"],"award-info":[{"award-number":["82270470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"DOI":"10.1007\/s00395-023-01014-0","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T17:01:38Z","timestamp":1696870898000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia\/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion"],"prefix":"10.1007","volume":"118","author":[{"given":"Dina","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanliang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingbiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Degang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naishi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zequan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0311-4794","authenticated-orcid":false,"given":"Yikui","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"1014_CR1","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1093\/cvr\/cvz050","volume":"115","author":"I Andreadou","year":"2019","unstructured":"Andreadou I, Cabrera-Fuentes HA, Devaux Y, Frangogiannis NG, Frantz S, Guzik T, Liehn EA, Gomes CPC, Schulz R, Hausenloy DJ (2019) Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities. Cardiovasc Res 115:1117\u20131130. https:\/\/doi.org\/10.1093\/cvr\/cvz050","journal-title":"Cardiovasc Res"},{"key":"1014_CR2","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1084\/jem.20050914","volume":"202","author":"FJ Barrat","year":"2005","unstructured":"Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL (2005) Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 202:1131\u20131139. https:\/\/doi.org\/10.1084\/jem.20050914","journal-title":"J Exp Med"},{"key":"1014_CR3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s00395-016-0553-6","volume":"111","author":"M Bliksoen","year":"2016","unstructured":"Bliksoen M, Mariero LH, Torp MK, Baysa A, Ytrehus K, Haugen F, Seljeflot I, Vaage J, Valen G, Stenslokken KO (2016) Extracellular mtDNA activates NF-kappaB via toll-like receptor 9 and induces cell death in cardiomyocytes. Basic Res Cardiol 111:42. https:\/\/doi.org\/10.1007\/s00395-016-0553-6","journal-title":"Basic Res Cardiol"},{"key":"1014_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00395-018-0696-8","volume":"113","author":"HE Botker","year":"2018","unstructured":"Botker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmino S, Garcia-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhauser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schluter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https:\/\/doi.org\/10.1007\/s00395-018-0696-8","journal-title":"Basic Res Cardiol"},{"key":"1014_CR5","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1159\/000335216","volume":"4","author":"JM den Haan","year":"2012","unstructured":"den Haan JM, Kraal G (2012) Innate immune functions of macrophage subpopulations in the spleen. J Innate Immun 4:437\u2013445. https:\/\/doi.org\/10.1159\/000335216","journal-title":"J Innate Immun"},{"key":"1014_CR6","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nature11260","volume":"487","author":"P Dutta","year":"2012","unstructured":"Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M (2012) Myocardial infarction accelerates atherosclerosis. Nature 487:325\u2013329. https:\/\/doi.org\/10.1038\/nature11260","journal-title":"Nature"},{"key":"1014_CR7","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/nm.2507","volume":"17","author":"HK Eltzschig","year":"2011","unstructured":"Eltzschig HK, Eckle T (2011) Ischemia and reperfusion\u2013from mechanism to translation. Nat Med 17:1391\u20131401. https:\/\/doi.org\/10.1038\/nm.2507","journal-title":"Nat Med"},{"key":"1014_CR8","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jcmg.2014.10.009","volume":"8","author":"H Emami","year":"2015","unstructured":"Emami H, Singh P, MacNabb M, Vucic E, Lavender Z, Rudd JH, Fayad ZA, Lehrer-Graiwer J, Korsgren M, Figueroa AL, Fredrickson J, Rubin B, Hoffmann U, Truong QA, Min JK, Baruch A, Nasir K, Nahrendorf M, Tawakol A (2015) Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans. JACC Cardiovasc Imaging 8:121\u2013130. https:\/\/doi.org\/10.1016\/j.jcmg.2014.10.009","journal-title":"JACC Cardiovasc Imaging"},{"issue":"35\u201344","key":"1014_CR9","doi-asserted-by":"publisher","first-page":"e36","DOI":"10.1016\/j.immuni.2017.11.013","volume":"48","author":"CL Evavold","year":"2018","unstructured":"Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC (2018) The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity 48(35\u201344):e36. https:\/\/doi.org\/10.1016\/j.immuni.2017.11.013","journal-title":"Immunity"},{"key":"1014_CR10","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1038\/sj.cdd.4402194","volume":"14","author":"T Fernandes-Alnemri","year":"2007","unstructured":"Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, Rosenberg S, Zhang J, Alnemri ES (2007) The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 14:1590\u20131604. https:\/\/doi.org\/10.1038\/sj.cdd.4402194","journal-title":"Cell Death Differ"},{"key":"1014_CR11","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1600-065X.2008.00734.x","volume":"227","author":"L Franchi","year":"2009","unstructured":"Franchi L, Warner N, Viani K, Nunez G (2009) Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev 227:106\u2013128. https:\/\/doi.org\/10.1111\/j.1600-065X.2008.00734.x","journal-title":"Immunol Rev"},{"key":"1014_CR12","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.bbi.2015.10.009","volume":"55","author":"MG Frank","year":"2016","unstructured":"Frank MG, Weber MD, Fonken LK, Hershman SA, Watkins LR, Maier SF (2016) The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome. Brain Behav Immun 55:215\u2013224. https:\/\/doi.org\/10.1016\/j.bbi.2015.10.009","journal-title":"Brain Behav Immun"},{"key":"1014_CR13","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1093\/cvr\/21.7.537","volume":"21","author":"D Garcia-Dorado","year":"1987","unstructured":"Garcia-Dorado D, Theroux P, Elizaga J, Galinanes M, Solares J, Riesgo M, Gomez MJ, Garcia-Dorado A, Fernandez Aviles F (1987) Myocardial reperfusion in the pig heart model: infarct size and duration of coronary occlusion. Cardiovasc Res 21:537\u2013544. https:\/\/doi.org\/10.1093\/cvr\/21.7.537","journal-title":"Cardiovasc Res"},{"key":"1014_CR14","first-page":"1","volume":"36","author":"DH Glogar","year":"1986","unstructured":"Glogar DH (1986) Definition and significance of the area at risk in myocardial infarct and the ischemic border zone in acute myocardial infarct. Acta Med Austriaca Suppl 36:1\u201340","journal-title":"Acta Med Austriaca Suppl"},{"key":"1014_CR15","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nm.3893","volume":"21","author":"H Guo","year":"2015","unstructured":"Guo H, Callaway JB, Ting JP (2015) Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med 21:677\u2013687. https:\/\/doi.org\/10.1038\/nm.3893","journal-title":"Nat Med"},{"key":"1014_CR16","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/imr.12285","volume":"265","author":"M Haneklaus","year":"2015","unstructured":"Haneklaus M, O\u2019Neill LA (2015) NLRP3 at the interface of metabolism and inflammation. Immunol Rev 265:53\u201362. https:\/\/doi.org\/10.1111\/imr.12285","journal-title":"Immunol Rev"},{"key":"1014_CR17","doi-asserted-by":"publisher","first-page":"107424842311796","DOI":"10.1177\/10742484231179613","volume":"28","author":"G Heusch","year":"2023","unstructured":"Heusch G (2023) Cardioprotection and its Translation: A Need for New Paradigms? Or for New Pragmatism? An Opinionated Retro- and Perspective. J Cardiovasc Pharmacol Ther 28:10742484231179612. https:\/\/doi.org\/10.1177\/10742484231179613","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"1014_CR18","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.117.310820","volume":"120","author":"G Heusch","year":"2017","unstructured":"Heusch G (2017) Critical Issues for the Translation of Cardioprotection. Circ Res 120:1477\u20131486. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.310820","journal-title":"Circ Res"},{"key":"1014_CR19","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","volume":"17","author":"G Heusch","year":"2020","unstructured":"Heusch G (2020) Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17:773\u2013789. https:\/\/doi.org\/10.1038\/s41569-020-0403-y","journal-title":"Nat Rev Cardiol"},{"key":"1014_CR20","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1161\/CIRCRESAHA.118.314331","volume":"124","author":"G Heusch","year":"2019","unstructured":"Heusch G (2019) The Spleen in Myocardial Infarction. Circ Res 124:26\u201328. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.314331","journal-title":"Circ Res"},{"key":"1014_CR21","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1007\/s10741-022-10248-4","volume":"27","author":"H Hiraiwa","year":"2022","unstructured":"Hiraiwa H, Okumura T, Murohara T (2022) The cardiosplenic axis: the prognostic role of the spleen in heart failure. Heart Fail Rev 27:2005\u20132015. https:\/\/doi.org\/10.1007\/s10741-022-10248-4","journal-title":"Heart Fail Rev"},{"key":"1014_CR22","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1161\/CIRCRESAHA.113.301720","volume":"114","author":"MA Ismahil","year":"2014","unstructured":"Ismahil MA, Hamid T, Bansal SS, Patel B, Kingery JR, Prabhu SD (2014) Remodeling of the mononuclear phagocyte network underlies chronic inflammation and disease progression in heart failure: critical importance of the cardiosplenic axis. Circ Res 114:266\u2013282. https:\/\/doi.org\/10.1161\/CIRCRESAHA.113.301720","journal-title":"Circ Res"},{"key":"1014_CR23","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1084\/jem.20171419","volume":"214","author":"H Jiang","year":"2017","unstructured":"Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W, Deng X, Zhou R (2017) Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med 214:3219\u20133238. https:\/\/doi.org\/10.1084\/jem.20171419","journal-title":"J Exp Med"},{"key":"1014_CR24","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1161\/CIRCULATIONAHA.110.982777","volume":"123","author":"M Kawaguchi","year":"2011","unstructured":"Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U (2011) Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia\/reperfusion injury. Circulation 123:594\u2013604. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.982777","journal-title":"Circulation"},{"key":"1014_CR25","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nri2215","volume":"8","author":"H Kono","year":"2008","unstructured":"Kono H, Rock KL (2008) How dying cells alert the immune system to danger. Nat Rev Immunol 8:279\u2013289. https:\/\/doi.org\/10.1038\/nri2215","journal-title":"Nat Rev Immunol"},{"key":"1014_CR26","doi-asserted-by":"publisher","first-page":"C1304","DOI":"10.1152\/ajpcell.00230.2022","volume":"323","author":"A Kubota","year":"2022","unstructured":"Kubota A, Frangogiannis NG (2022) Macrophages in myocardial infarction. Am J Physiol Cell Physiol 323:C1304\u2013C1324. https:\/\/doi.org\/10.1152\/ajpcell.00230.2022","journal-title":"Am J Physiol Cell Physiol"},{"key":"1014_CR27","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/j.1600-065X.2011.01043.x","volume":"243","author":"JC Leemans","year":"2011","unstructured":"Leemans JC, Cassel SL, Sutterwala FS (2011) Sensing damage by the NLRP3 inflammasome. Immunol Rev 243:152\u2013162. https:\/\/doi.org\/10.1111\/j.1600-065X.2011.01043.x","journal-title":"Immunol Rev"},{"key":"1014_CR28","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.bbi.2019.04.010","volume":"80","author":"L Li","year":"2019","unstructured":"Li L, Ni L, Eugenin EA, Heary RF, Elkabes S (2019) Toll-like receptor 9 antagonism modulates astrocyte function and preserves proximal axons following spinal cord injury. Brain Behav Immun 80:328\u2013343. https:\/\/doi.org\/10.1016\/j.bbi.2019.04.010","journal-title":"Brain Behav Immun"},{"key":"1014_CR29","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1161\/CIRCRESAHA.118.313859","volume":"123","author":"HR Lieder","year":"2018","unstructured":"Lieder HR, Kleinbongard P, Skyschally A, Hagelschuer H, Chilian WM, Heusch G (2018) Vago-Splenic Axis in Signal Transduction of Remote Ischemic Preconditioning in Pigs and Rats. Circ Res 123:1152\u20131163. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313859","journal-title":"Circ Res"},{"key":"1014_CR30","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00395-017-0663-9","volume":"113","author":"D Liu","year":"2018","unstructured":"Liu D, Zeng X, Li X, Mehta JL, Wang X (2018) Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases. Basic Res Cardiol 113:5. https:\/\/doi.org\/10.1007\/s00395-017-0663-9","journal-title":"Basic Res Cardiol"},{"key":"1014_CR31","doi-asserted-by":"publisher","first-page":"661","DOI":"10.7754\/clin.lab.2014.141132","volume":"61","author":"J Liu","year":"2015","unstructured":"Liu J, Cai X, Xie L, Tang Y, Cheng J, Wang J, Wang L, Gong J (2015) Circulating Cell Free Mitochondrial DNA is a Biomarker in the Development of Coronary Heart Disease in the Patients with Type 2 Diabetes. Clin Lab 61:661\u2013667. https:\/\/doi.org\/10.7754\/clin.lab.2014.141132","journal-title":"Clin Lab"},{"key":"1014_CR32","doi-asserted-by":"publisher","first-page":"680648","DOI":"10.3389\/fimmu.2021.680648","volume":"12","author":"J Liu","year":"2021","unstructured":"Liu J, Jia Z, Gong W (2021) Circulating Mitochondrial DNA Stimulates Innate Immune Signaling Pathways to Mediate Acute Kidney Injury. Front Immunol 12:680648. https:\/\/doi.org\/10.3389\/fimmu.2021.680648","journal-title":"Front Immunol"},{"key":"1014_CR33","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/s1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417\u2013426. https:\/\/doi.org\/10.1016\/s1097-2765(02)00599-3","journal-title":"Mol Cell"},{"key":"1014_CR34","doi-asserted-by":"publisher","first-page":"5271251","DOI":"10.1155\/2016\/5271251","volume":"2016","author":"R Mastrocola","year":"2016","unstructured":"Mastrocola R, Penna C, Tullio F, Femmino S, Nigro D, Chiazza F, Serpe L, Collotta D, Alloatti G, Cocco M, Bertinaria M, Pagliaro P, Aragno M, Collino M (2016) Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia\/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways. Oxid Med Cell Longev 2016:5271251. https:\/\/doi.org\/10.1155\/2016\/5271251","journal-title":"Oxid Med Cell Longev"},{"key":"1014_CR35","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1161\/CIRCULATIONAHA.118.033942","volume":"139","author":"M Mauler","year":"2019","unstructured":"Mauler M, Herr N, Schoenichen C, Witsch T, Marchini T, Hardtner C, Koentges C, Kienle K, Ollivier V, Schell M, Dorner L, Wippel C, Stallmann D, Normann C, Bugger H, Walther P, Wolf D, Ahrens I, Lammermann T, Ho-Tin-Noe B, Ley K, Bode C, Hilgendorf I, Duerschmied D (2019) Platelet Serotonin Aggravates Myocardial Ischemia\/Reperfusion Injury via Neutrophil Degranulation. Circulation 139:918\u2013931. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.033942","journal-title":"Circulation"},{"key":"1014_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2249.2011.04440.x","volume":"166","author":"P Menu","year":"2011","unstructured":"Menu P, Vince JE (2011) The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin Exp Immunol 166:1\u201315. https:\/\/doi.org\/10.1111\/j.1365-2249.2011.04440.x","journal-title":"Clin Exp Immunol"},{"key":"1014_CR37","doi-asserted-by":"publisher","first-page":"19725","DOI":"10.1073\/pnas.1108586108","volume":"108","author":"E Mezzaroma","year":"2011","unstructured":"Mezzaroma E, Toldo S, Farkas D, Seropian IM, Van Tassell BW, Salloum FN, Kannan HR, Menna AC, Voelkel NF, Abbate A (2011) The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc Natl Acad Sci USA 108:19725\u201319730. https:\/\/doi.org\/10.1073\/pnas.1108586108","journal-title":"Proc Natl Acad Sci USA"},{"key":"1014_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/biology11010116","author":"CS Mildner","year":"2022","unstructured":"Mildner CS, Copic D, Zimmermann M, Lichtenauer M, Direder M, Klas K, Bormann D, Gugerell A, Moser B, Hoetzenecker K, Beer L, Gyongyosi M, Ankersmit HJ, Laggner M (2022) Secretome of Stressed Peripheral Blood Mononuclear Cells Alters Transcriptome Signature in Heart, Liver, and Spleen after an Experimental Acute Myocardial Infarction: An In Silico Analysis. Biology (Basel). https:\/\/doi.org\/10.3390\/biology11010116","journal-title":"Biology (Basel)"},{"key":"1014_CR39","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1093\/cvr\/cvz336","volume":"116","author":"C Peet","year":"2020","unstructured":"Peet C, Ivetic A, Bromage DI, Shah AM (2020) Cardiac monocytes and macrophages after myocardial infarction. Cardiovasc Res 116:1101\u20131112. https:\/\/doi.org\/10.1093\/cvr\/cvz336","journal-title":"Cardiovasc Res"},{"key":"1014_CR40","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/bf00584977","volume":"36","author":"H Rein","year":"1949","unstructured":"Rein H (1949) \u00dcber ein Regulationssystem \u201cMilz-Leber\u201d f\u00fcr den oxydativen Stoffwechsel der K\u00f6rpergewebe und besonders des Herzens. Naturwissenschaften 36:260\u2013268. https:\/\/doi.org\/10.1007\/bf00584977","journal-title":"Naturwissenschaften"},{"key":"1014_CR41","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1161\/01.cir.67.5.1016","volume":"67","author":"JL Romson","year":"1983","unstructured":"Romson JL, Hook BG, Kunkel SL, Abrams GD, Schork MA, Lucchesi BR (1983) Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 67:1016\u20131023. https:\/\/doi.org\/10.1161\/01.cir.67.5.1016","journal-title":"Circulation"},{"key":"1014_CR42","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/s41401-018-0197-1","volume":"40","author":"V Rusinkevich","year":"2019","unstructured":"Rusinkevich V, Huang Y, Chen ZY, Qiang W, Wang YG, Shi YF, Yang HT (2019) Temporal dynamics of immune response following prolonged myocardial ischemia\/reperfusion with and without cyclosporine A. Acta Pharmacol Sin 40:1168\u20131183. https:\/\/doi.org\/10.1038\/s41401-018-0197-1","journal-title":"Acta Pharmacol Sin"},{"key":"1014_CR43","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/s41418-018-0131-6","volume":"26","author":"Y Saito","year":"2019","unstructured":"Saito Y, Hikita H, Nozaki Y, Kai Y, Makino Y, Nakabori T, Tanaka S, Yamada R, Shigekawa M, Kodama T, Sakamori R, Tatsumi T, Takehara T (2019) DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9\/IFN-beta signaling pathway. Cell Death Differ 26:470\u2013486. https:\/\/doi.org\/10.1038\/s41418-018-0131-6","journal-title":"Cell Death Differ"},{"key":"1014_CR44","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.bbrc.2015.12.051","volume":"469","author":"O Sandanger","year":"2016","unstructured":"Sandanger O, Gao E, Ranheim T, Bliksoen M, Kaasboll OJ, Alfsnes K, Nymo SH, Rashidi A, Ohm IK, Attramadal H, Aukrust P, Vinge LE, Yndestad A (2016) NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective. Biochem Biophys Res Commun 469:1012\u20131020. https:\/\/doi.org\/10.1016\/j.bbrc.2015.12.051","journal-title":"Biochem Biophys Res Commun"},{"key":"1014_CR45","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1093\/cvr\/cvt091","volume":"99","author":"O Sandanger","year":"2013","unstructured":"Sandanger O, Ranheim T, Vinge LE, Bliksoen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A (2013) The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovasc Res 99:164\u2013174. https:\/\/doi.org\/10.1093\/cvr\/cvt091","journal-title":"Cardiovasc Res"},{"key":"1014_CR46","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.trsl.2015.07.002","volume":"167","author":"A Saxena","year":"2016","unstructured":"Saxena A, Russo I, Frangogiannis NG (2016) Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges. Transl Res 167:152\u2013166. https:\/\/doi.org\/10.1016\/j.trsl.2015.07.002","journal-title":"Transl Res"},{"key":"1014_CR47","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","volume":"36","author":"K Shimada","year":"2012","unstructured":"Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M (2012) Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36:401\u2013414. https:\/\/doi.org\/10.1016\/j.immuni.2012.01.009","journal-title":"Immunity"},{"key":"1014_CR48","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1126\/science.1175202","volume":"325","author":"FK Swirski","year":"2009","unstructured":"Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ (2009) Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 325:612\u2013616. https:\/\/doi.org\/10.1126\/science.1175202","journal-title":"Science"},{"key":"1014_CR49","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/FJC.0000000000000709","volume":"74","author":"M Takahashi","year":"2019","unstructured":"Takahashi M (2019) Cell-Specific Roles of NLRP3 Inflammasome in Myocardial Infarction. J Cardiovasc Pharmacol 74:188\u2013193. https:\/\/doi.org\/10.1097\/FJC.0000000000000709","journal-title":"J Cardiovasc Pharmacol"},{"key":"1014_CR50","doi-asserted-by":"publisher","first-page":"e2253","DOI":"10.1016\/j.jtcvs.2018.09.043","volume":"157","author":"Y Tian","year":"2019","unstructured":"Tian Y, Charles EJ, Yan Z, Wu D, French BA, Kron IL, Yang Z (2019) The myocardial infarct-exacerbating effect of cell-free DNA is mediated by the high-mobility group box 1-receptor for advanced glycation end products-Toll-like receptor 9 pathway. J Thorac Cardiovasc Surg 157:e2253. https:\/\/doi.org\/10.1016\/j.jtcvs.2018.09.043","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1014_CR51","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00395-015-0496-3","volume":"110","author":"Y Tian","year":"2015","unstructured":"Tian Y, French BA, Kron IL, Yang Z (2015) Splenic leukocytes mediate the hyperglycemic exacerbation of myocardial infarct size in mice. Basic Res Cardiol 110:39. https:\/\/doi.org\/10.1007\/s00395-015-0496-3","journal-title":"Basic Res Cardiol"},{"key":"1014_CR52","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1253\/circj.CJ-18-0061","volume":"82","author":"Y Tian","year":"2018","unstructured":"Tian Y, Miao B, Charles EJ, Wu D, Kron IL, French BA, Yang Z (2018) Stimulation of the Beta2 Adrenergic Receptor at Reperfusion Limits Myocardial Reperfusion Injury via an Interleukin-10-Dependent Anti-Inflammatory Pathway in the Spleen. Circ J 82:2829\u20132836. https:\/\/doi.org\/10.1253\/circj.CJ-18-0061","journal-title":"Circ J"},{"key":"1014_CR53","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s00395-016-0583-0","volume":"111","author":"Y Tian","year":"2016","unstructured":"Tian Y, Pan D, Chordia MD, French BA, Kron IL, Yang Z (2016) The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE. Basic Res Cardiol 111:62. https:\/\/doi.org\/10.1007\/s00395-016-0583-0","journal-title":"Basic Res Cardiol"},{"key":"1014_CR54","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/FJC.0000000000000658","volume":"73","author":"S Toldo","year":"2019","unstructured":"Toldo S, Mauro AG, Cutter Z, Van Tassell BW, Mezzaroma E, Del Buono MG, Prestamburgo A, Potere N, Abbate A (2019) The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol 73:215\u2013222. https:\/\/doi.org\/10.1097\/FJC.0000000000000658","journal-title":"J Cardiovasc Pharmacol"},{"key":"1014_CR55","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jaut.2018.02.010","volume":"91","author":"AG Vakrakou","year":"2018","unstructured":"Vakrakou AG, Boiu S, Ziakas PD, Xingi E, Boleti H, Manoussakis MN (2018) Systemic activation of NLRP3 inflammasome in patients with severe primary Sjogren\u2019s syndrome fueled by inflammagenic DNA accumulations. J Autoimmun 91:23\u201333. https:\/\/doi.org\/10.1016\/j.jaut.2018.02.010","journal-title":"J Autoimmun"},{"key":"1014_CR56","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/eurheartj\/eht331","volume":"35","author":"AM van der Laan","year":"2014","unstructured":"van der Laan AM, Ter Horst EN, Delewi R, Begieneman MP, Krijnen PA, Hirsch A, Lavaei M, Nahrendorf M, Horrevoets AJ, Niessen HW, Piek JJ (2014) Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir. Eur Heart J 35:376\u2013385. https:\/\/doi.org\/10.1093\/eurheartj\/eht331","journal-title":"Eur Heart J"},{"key":"1014_CR57","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1161\/CIRCRESAHA.113.300765","volume":"113","author":"RS Vander Heide","year":"2013","unstructured":"Vander Heide RS, Steenbergen C (2013) Cardioprotection and myocardial reperfusion: pitfalls to clinical application. Circ Res 113:464\u2013477. https:\/\/doi.org\/10.1161\/CIRCRESAHA.113.300765","journal-title":"Circ Res"},{"key":"1014_CR58","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","volume":"44","author":"TA Wynn","year":"2016","unstructured":"Wynn TA, Vannella KM (2016) Macrophages in Tissue Repair, Regeneration, and Fibrosis. Immunity 44:450\u2013462. https:\/\/doi.org\/10.1016\/j.immuni.2016.02.015","journal-title":"Immunity"},{"key":"1014_CR59","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2013.04.023","volume":"62","author":"X Yan","year":"2013","unstructured":"Yan X, Anzai A, Katsumata Y, Matsuhashi T, Ito K, Endo J, Yamamoto T, Takeshima A, Shinmura K, Shen W, Fukuda K, Sano M (2013) Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction. J Mol Cell Cardiol 62:24\u201335. https:\/\/doi.org\/10.1016\/j.yjmcc.2013.04.023","journal-title":"J Mol Cell Cardiol"},{"key":"1014_CR60","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1161\/01.CIR.0000163586.62253.A5","volume":"111","author":"Z Yang","year":"2005","unstructured":"Yang Z, Day Y-J, Toufektsian M-C, Ramos SI, Marshall M, Wang X-Q, French BA, Linden J (2005) Infarct-sparing effect of A2A-adenosine receptor activation is due primarily to its action on lymphocytes. Circulation 111:2190\u20132197","journal-title":"Circulation"},{"key":"1014_CR61","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1161\/CIRCULATIONAHA.106.649244","volume":"114","author":"Z Yang","year":"2006","unstructured":"Yang Z, Day Y-J, Toufektsian M-C, Xu Y, Ramos SI, Marshall MA, French BA, Linden J (2006) Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes. Circulation 114:2056\u20132064","journal-title":"Circulation"},{"key":"1014_CR62","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.jtcvs.2008.08.056","volume":"137","author":"Z Yang","year":"2009","unstructured":"Yang Z, Laubach VE, French BA, Kron IL (2009) Acute hyperglycemia enhances oxidative stress and exacerbates myocardial infarction by activating nicotinamide adenine dinucleotide phosphate oxidase during reperfusion. J Thorac Cardiovasc Surg 137:723\u2013729. https:\/\/doi.org\/10.1016\/j.jtcvs.2008.08.056","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1014_CR63","doi-asserted-by":"publisher","first-page":"H2328","DOI":"10.1152\/ajpheart.00091.2008","volume":"295","author":"Z Yang","year":"2008","unstructured":"Yang Z, Linden J, Berr SS, Kron IL, Beller GA, French BA (2008) Timing of adenosine 2A receptor stimulation relative to reperfusion has differential effects on infarct size and cardiac function as assessed in mice by MRI. Am J Physiol Heart Circ Physiol 295:H2328-2335. https:\/\/doi.org\/10.1152\/ajpheart.00091.2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1014_CR64","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1056\/NEJMra071667","volume":"357","author":"DM Yellon","year":"2007","unstructured":"Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357:1121\u20131135. https:\/\/doi.org\/10.1056\/NEJMra071667","journal-title":"N Engl J Med"},{"key":"1014_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112219","volume":"143","author":"X Zhang","year":"2021","unstructured":"Zhang X, Qu H, Yang T, Kong X, Zhou H (2021) Regulation and functions of NLRP3 inflammasome in cardiac fibrosis: Current knowledge and clinical significance. Biomed Pharmacother 143:112219. https:\/\/doi.org\/10.1016\/j.biopha.2021.112219","journal-title":"Biomed Pharmacother"},{"key":"1014_CR66","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","volume":"15","author":"J Zindel","year":"2020","unstructured":"Zindel J, Kubes P (2020) DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. Annu Rev Pathol 15:493\u2013518. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-012419-032847","journal-title":"Annu Rev Pathol"},{"key":"1014_CR67","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/FJC.0000000000000696","volume":"74","author":"CJ Zuurbier","year":"2019","unstructured":"Zuurbier CJ (2019) NLRP3 Inflammasome in Cardioprotective Signaling. J Cardiovasc Pharmacol 74:271\u2013275. https:\/\/doi.org\/10.1097\/FJC.0000000000000696","journal-title":"J Cardiovasc Pharmacol"},{"key":"1014_CR68","doi-asserted-by":"publisher","first-page":"e40643","DOI":"10.1371\/journal.pone.0040643","volume":"7","author":"CJ Zuurbier","year":"2012","unstructured":"Zuurbier CJ, Jong WM, Eerbeek O, Koeman A, Pulskens WP, Butter LM, Leemans JC, Hollmann MW (2012) Deletion of the innate immune NLRP3 receptor abolishes cardiac ischemic preconditioning and is associated with decreased Il-6\/STAT3 signaling. PLoS ONE 7:e40643. https:\/\/doi.org\/10.1371\/journal.pone.0040643","journal-title":"PLoS ONE"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-023-01014-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-023-01014-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-023-01014-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T14:08:14Z","timestamp":1702649294000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-023-01014-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,9]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1014"],"URL":"https:\/\/doi.org\/10.1007\/s00395-023-01014-0","relation":{},"ISSN":["1435-1803"],"issn-type":[{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,9]]},"assertion":[{"value":"15 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"44"}}