{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:08:37Z","timestamp":1792210117490,"version":"4.4.0"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["413657723"],"award-info":[{"award-number":["413657723"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["453989101"],"award-info":[{"award-number":["453989101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["453989101"],"award-info":[{"award-number":["453989101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["453989101"],"award-info":[{"award-number":["453989101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["453989101"],"award-info":[{"award-number":["453989101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["453989101"],"award-info":[{"award-number":["453989101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["453989101"],"award-info":[{"award-number":["453989101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","award":["E-298"],"award-info":[{"award-number":["E-298"]}],"id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","award":["E-298"],"award-info":[{"award-number":["E-298"]}],"id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e4tsklinikum W\u00fcrzburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Though myocardial infarction (MI) in pigs is a well-established translational large animal model, it has not yet been widely used for immunotherapy studies, and a comprehensive description of the immune response to MI in this species is lacking. We induced MI in Landrace pigs by balloon occlusion of the left anterior descending artery over 90\u00a0min. Within 14\u00a0days, the necrotic myocardium was progressively replaced by scar tissue with involvement of myofibroblasts. We characterized the immune response in the heart ex vivo by (immuno)histology, flow cytometry, and RNA sequencing of myocardial tissue on days 3, 7, and 14 after MI. Besides a clear predominance of myeloid cells among heart-infiltrating leukocytes, we detected activated T cells and an increasing proportion of CD4\n                    <jats:sup>+<\/jats:sup>\n                    Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells (T\n                    <jats:sub>reg<\/jats:sub>\n                    ), especially in the infarct core\u2014findings that closely mirror what has been observed in mice and humans after MI. Transcriptome data indicated inflammatory activity that was persistent but markedly changing in character over time and linked to extracellular matrix biology. Analysis of lymphocytes in heart-draining lymph nodes revealed significantly higher proliferation rates of T helper cell subsets, including T\n                    <jats:sub>reg<\/jats:sub>\n                    on day 7 after MI, compared to sham controls. Elevated frequencies of myeloid progenitors in the spleen suggest that it might be a site of emergency myelopoiesis after MI in pigs, as previously shown in mice. We thus provide a first description of the immune response to MI in pigs, and our results can aid future research using the species for preclinical immunotherapy studies.\n                  <\/jats:p>","DOI":"10.1007\/s00395-024-01036-2","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T13:01:56Z","timestamp":1710507716000},"page":"453-479","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Characterizing the immune response to myocardial infarction in pigs"],"prefix":"10.1007","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7583-4224","authenticated-orcid":false,"given":"Florian","family":"Schnitter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Stangl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Noeske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Bille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Stadtm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Sicklinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1157-474X","authenticated-orcid":false,"given":"Florian","family":"Leuschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2955-6753","authenticated-orcid":false,"given":"Anna","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8827-1838","authenticated-orcid":false,"given":"Laura","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-6185","authenticated-orcid":false,"given":"Stefan","family":"Frantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9236-5415","authenticated-orcid":false,"given":"Niklas","family":"Beyersdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9582-2725","authenticated-orcid":false,"given":"Gustavo","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0919-6348","authenticated-orcid":false,"given":"Nadine","family":"Gladow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3681-2073","authenticated-orcid":false,"given":"Ulrich","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"1036_CR1","doi-asserted-by":"publisher","first-page":"166ral","DOI":"10.1126\/scitranslmed.3004853","volume":"5","author":"RH Al-Mashhadi","year":"2013","unstructured":"Al-Mashhadi RH, S\u00f8rensen CB, Kragh PM, Christoffersen C, Mortensen MB, Tolbod LP, Thim T, Du Y, Li J, Liu Y, Moldt B, Schmidt M, Vajta G, Larsen T, Purup S, Bolund L, Nielsen LB, Callesen H, Falk E, Mikkelsen JG, Bentzon JF (2013) Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant. Sci Transl Med 5:166ral. https:\/\/doi.org\/10.1126\/scitranslmed.3004853","journal-title":"Sci Transl Med"},{"key":"1036_CR2","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/s41591-018-0059-x","volume":"24","author":"G Bajpai","year":"2018","unstructured":"Bajpai G, Schneider C, Wong N, Bredemeyer A, Hulsmans M, Nahrendorf M, Epelman S, Kreisel D, Liu Y, Itoh A, Shankar TS, Selzman CH, Drakos SG, Lavine KJ (2018) The human heart contains distinct macrophage subsets with divergent origins and functions. Nat Med 24:1234\u20131245. https:\/\/doi.org\/10.1038\/s41591-018-0059-x","journal-title":"Nat Med"},{"key":"1036_CR3","doi-asserted-by":"publisher","first-page":"iv91","DOI":"10.1136\/ard.2005.042564","volume":"64","author":"N Beyersdorf","year":"2005","unstructured":"Beyersdorf N (2005) Superagonistic anti-CD28 antibodies: potent activators of regulatory T cells for the therapy of autoimmune diseases. Ann Rheum Dis 64:iv91\u2013iv95. https:\/\/doi.org\/10.1136\/ard.2005.042564","journal-title":"Ann Rheum Dis"},{"key":"1036_CR4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00395-022-00928-5","volume":"117","author":"F B\u00f6nner","year":"2022","unstructured":"B\u00f6nner F, Gastl M, Nienhaus F, Rothe M, Jahn A, Pfeiler S, Gross U, Schultheiss H-P, Ibanez B, Kozerke S, Szendroedi J, Roden M, Westenfeld R, Schrader J, Fl\u00f6gel U, Heusch G, Kelm M (2022) Regional analysis of inflammation and contractile function in reperfused acute myocardial infarction by in vivo 19F cardiovascular magnetic resonance in pigs. Basic Res Cardiol 117:21. https:\/\/doi.org\/10.1007\/s00395-022-00928-5","journal-title":"Basic Res Cardiol"},{"key":"1036_CR5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00395-018-0696-8","volume":"113","author":"HE B\u00f8tker","year":"2018","unstructured":"B\u00f8tker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmin\u00f2 S, Garc\u00eda-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuh\u00e4user M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schl\u00fcter K-D, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https:\/\/doi.org\/10.1007\/s00395-018-0696-8","journal-title":"Basic Res Cardiol"},{"key":"1036_CR6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/s0165-2427(02)00170-8","volume":"89","author":"A Carrillo","year":"2002","unstructured":"Carrillo A, Chamorro S, Rodr\u00edguez-Gago M, Alvarez B, Molina MJ, Rodr\u00edguez-Barbosa JI, S\u00e1nchez A, Ram\u00edrez P, Mu\u00f1oz A, Dom\u00ednguez J, Parrilla P, Y\u00e9lamos J (2002) Isolation and characterization of immortalized porcine aortic endothelial cell lines. Vet Immunol Immunopathol 89:91\u201398. https:\/\/doi.org\/10.1016\/s0165-2427(02)00170-8","journal-title":"Vet Immunol Immunopathol"},{"key":"1036_CR7","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.3390\/ani11041098","volume":"11","author":"T Carta","year":"2021","unstructured":"Carta T, Razzuoli E, Fruscione F, Zinellu S, Meloni D, Anfossi A, Chessa B, Dei Giudici S, Graham SP, Oggiano A, Franzoni G (2021) Comparative phenotypic and functional analyses of the effects of IL-10 or TGF-\u03b2 on porcine macrophages. Animals 11:1098. https:\/\/doi.org\/10.3390\/ani11041098","journal-title":"Animals"},{"key":"1036_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mpdhp.2012.11.001","volume":"19","author":"J Chang","year":"2013","unstructured":"Chang J, Nair V, Luk A, Butany J (2013) Pathology of myocardial infarction. Diagn Histopathol 19:7\u201312. https:\/\/doi.org\/10.1016\/j.mpdhp.2012.11.001","journal-title":"Diagn Histopathol"},{"key":"1036_CR9","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.dci.2019.03.020","volume":"98","author":"C Chen","year":"2019","unstructured":"Chen C, Perry TL, Chitko-McKown CG, Smith AD, Cheung L, Beshah E, Urban JF, Dawson HD (2019) The regulatory actions of retinoic acid on M2 polarization of porcine macrophages. Dev Comp Immunol 98:20\u201333. https:\/\/doi.org\/10.1016\/j.dci.2019.03.020","journal-title":"Dev Comp Immunol"},{"key":"1036_CR10","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1369\/0022155413493912","volume":"61","author":"P Christia","year":"2013","unstructured":"Christia P, Bujak M, Gonzalez-Quesada C, Chen W, Dobaczewski M, Reddy A, Frangogiannis NG (2013) Systematic characterization of myocardial inflammation, repair, and remodeling in a mouse model of reperfused myocardial infarction. J Histochem Cytochem 61:555\u2013570. https:\/\/doi.org\/10.1369\/0022155413493912","journal-title":"J Histochem Cytochem"},{"key":"1036_CR11","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.rvsc.2018.02.007","volume":"118","author":"HD Dawson","year":"2018","unstructured":"Dawson HD, Lunney JK (2018) Porcine cluster of differentiation (CD) markers 2018 update. Res Vet Sci 118:199\u2013246. https:\/\/doi.org\/10.1016\/j.rvsc.2018.02.007","journal-title":"Res Vet Sci"},{"key":"1036_CR12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.vetmic.2016.05.013","volume":"202","author":"HD Dawson","year":"2017","unstructured":"Dawson HD, Smith AD, Chen C, Urban JF (2017) An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome. Vet Microbiol 202:2\u201315. https:\/\/doi.org\/10.1016\/j.vetmic.2016.05.013","journal-title":"Vet Microbiol"},{"key":"1036_CR13","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/S0002-9440(10)63154-9","volume":"164","author":"O Dewald","year":"2004","unstructured":"Dewald O, Ren G, Duerr GD, Zoerlein M, Klemm C, Gersch C, Tincey S, Michael LH, Entman ML, Frangogiannis NG (2004) Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction. Am J Pathol 164:665\u2013677. https:\/\/doi.org\/10.1016\/S0002-9440(10)63154-9","journal-title":"Am J Pathol"},{"key":"1036_CR14","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.jacep.2016.11.010","volume":"3","author":"TS Dhanjal","year":"2017","unstructured":"Dhanjal TS, Lellouche N, von Ruhland CJ, Abehsira G, Edwards DH, Dubois-Rand\u00e9 J-L, Moschonas K, Teiger E, Williams AJ, George CH (2017) Massive accumulation of myofibroblasts in the critical isthmus is associated with ventricular tachycardia inducibility in post-infarct swine heart. JACC Clin Electrophysiol 3:703\u2013714. https:\/\/doi.org\/10.1016\/j.jacep.2016.11.010","journal-title":"JACC Clin Electrophysiol"},{"key":"1036_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29:15\u201321. https:\/\/doi.org\/10.1093\/bioinformatics\/bts635","journal-title":"Bioinformatics"},{"key":"1036_CR16","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nature11260","volume":"487","author":"P Dutta","year":"2012","unstructured":"Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HWM, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M (2012) Myocardial infarction accelerates atherosclerosis. Nature 487:325\u2013329. https:\/\/doi.org\/10.1038\/nature11260","journal-title":"Nature"},{"key":"1036_CR17","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.dci.2008.06.002","volume":"33","author":"A Ezquerra","year":"2009","unstructured":"Ezquerra A, Revilla C, Alvarez B, P\u00e9rez C, Alonso F, Dom\u00ednguez J (2009) Porcine myelomonocytic markers and cell populations. Dev Comp Immunol 33:284\u2013298. https:\/\/doi.org\/10.1016\/j.dci.2008.06.002","journal-title":"Dev Comp Immunol"},{"key":"1036_CR18","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1189\/jlb.1110607","volume":"89","author":"L Fairbairn","year":"2011","unstructured":"Fairbairn L, Kapetanovic R, Sester DP, Hume DA (2011) The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease. J Leukoc Biol 89:855\u2013871. https:\/\/doi.org\/10.1189\/jlb.1110607","journal-title":"J Leukoc Biol"},{"key":"1036_CR19","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1093\/cvr\/21.7.537","volume":"21","author":"D Garcia-Dorado","year":"1987","unstructured":"Garcia-Dorado D, Th\u00e9roux P, Elizaga J, Gali\u00f1anes M, Solares J, Riesgo M, Gomez MJ, Garcia-Dorado A, Fernandez Aviles F (1987) Myocardial reperfusion in the pig heart model: infarct size and duration of coronary occlusion. Cardiovasc Res 21:537\u2013544. https:\/\/doi.org\/10.1093\/cvr\/21.7.537","journal-title":"Cardiovasc Res"},{"key":"1036_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.molimm.2014.10.025","volume":"66","author":"W Gerner","year":"2015","unstructured":"Gerner W, Talker SC, Koinig HC, Sedlak C, Mair KH, Saalm\u00fcller A (2015) Phenotypic and functional differentiation of porcine \u03b1\u03b2 T cells: current knowledge and available tools. Mol Immunol 66:3\u201313. https:\/\/doi.org\/10.1016\/j.molimm.2014.10.025","journal-title":"Mol Immunol"},{"key":"1036_CR21","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/S0301-472X(03)00197-8","volume":"31","author":"AC Le Guern","year":"2003","unstructured":"Le Guern AC, Giovino MA, Abe M, Theodore PR, Qi J, Down JD, Sachs DH, Sykes M, Yang YG (2003) Stem cell activity of porcine c-kit+ hematopoietic cells. Exp Hematol 31:833\u2013840. https:\/\/doi.org\/10.1016\/S0301-472X(03)00197-8","journal-title":"Exp Hematol"},{"key":"1036_CR22","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019338","volume":"10","author":"C Hall","year":"2021","unstructured":"Hall C, Gehmlich K, Denning C, Pavlovic D (2021) Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease. J Am Heart Assoc 10:e019338. https:\/\/doi.org\/10.1161\/JAHA.120.019338","journal-title":"J Am Heart Assoc"},{"key":"1036_CR23","doi-asserted-by":"publisher","first-page":"2664","DOI":"10.1093\/cvr\/cvab181","volume":"117","author":"M Heinrichs","year":"2021","unstructured":"Heinrichs M, Ashour D, Siegel J, B\u00fcchner L, Wedekind G, Heinze KG, Arampatzi P, Saliba A-E, Cochain C, Hofmann U, Frantz S, Campos Ramos G (2021) The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism. Cardiovasc Res 117:2664\u20132676. https:\/\/doi.org\/10.1093\/cvr\/cvab181","journal-title":"Cardiovasc Res"},{"key":"1036_CR24","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1161\/CIRCRESAHA.118.314331","volume":"124","author":"G Heusch","year":"2019","unstructured":"Heusch G (2019) The spleen in myocardial infarction. Circ Res 124:26\u201328. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.314331","journal-title":"Circ Res"},{"key":"1036_CR25","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.yjmcc.2011.02.016","volume":"50","author":"G Heusch","year":"2011","unstructured":"Heusch G, Skyschally A, Schulz R (2011) The in-situ pig heart with regional ischemia\/reperfusion - ready for translation. J Mol Cell Cardiol 50:951\u2013963. https:\/\/doi.org\/10.1016\/j.yjmcc.2011.02.016","journal-title":"J Mol Cell Cardiol"},{"key":"1036_CR26","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jacc.2016.10.058","volume":"69","author":"R Hinkel","year":"2017","unstructured":"Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz K-L, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C (2017) Diabetes mellitus-induced microvascular destabilization in the myocardium. J Am Coll Cardiol 69:131\u2013143. https:\/\/doi.org\/10.1016\/j.jacc.2016.10.058","journal-title":"J Am Coll Cardiol"},{"key":"1036_CR27","doi-asserted-by":"publisher","first-page":"H684","DOI":"10.1152\/ajpheart.00304.2021","volume":"321","author":"ARH Hobby","year":"2021","unstructured":"Hobby ARH, Berretta RM, Eaton DM, Kubo H, Feldsott E, Yang Y, Headrick AL, Koch KA, Rubino M, Kurian J, Khan M, Tan Y, Mohsin S, Gallucci S, McKinsey TA, Houser SR (2021) Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype. Am J Physiol Circ Physiol 321:H684\u2013H701. https:\/\/doi.org\/10.1152\/ajpheart.00304.2021","journal-title":"Am J Physiol Circ Physiol"},{"key":"1036_CR28","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1161\/CIRCULATIONAHA.111.044164","volume":"125","author":"U Hofmann","year":"2012","unstructured":"Hofmann U, Beyersdorf N, Weirather J, Podolskaya A, Bauersachs J, Ertl G, Kerkau T, Frantz S (2012) Activation of CD4 + T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice. Circulation 125:1652\u20131663. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.044164","journal-title":"Circulation"},{"key":"1036_CR29","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1093\/eurheartj\/ehw247","volume":"38","author":"GPJ van Hout","year":"2017","unstructured":"van Hout GPJ, Bosch L, Ellenbroek GHJM, de Haan JJ, van Solinge WW, Cooper MA, Arslan F, de Jager SCA, Robertson AAB, Pasterkamp G, Hoefer IE (2017) The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction. Eur Heart J 38:828\u2013836. https:\/\/doi.org\/10.1093\/eurheartj\/ehw247","journal-title":"Eur Heart J"},{"key":"1036_CR30","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.jacbts.2022.11.006","volume":"8","author":"RD Hume","year":"2023","unstructured":"Hume RD, Deshmukh T, Doan T, Shim WJ, Kanagalingam S, Tallapragada V, Rashid F, Marcuello M, Blessing D, Selvakumar D, Raguram K, Pathan F, Graham D, Ounzain S, Kizana E, Harvey RP, Palpant NJ, Chong JJH (2023) PDGF-AB reduces myofibroblast differentiation without increasing proliferation after myocardial infarction. JACC Basic Transl Sci 8:658\u2013674. https:\/\/doi.org\/10.1016\/j.jacbts.2022.11.006","journal-title":"JACC Basic Transl Sci"},{"key":"1036_CR31","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jacbts.2019.02.006","volume":"4","author":"C Humeres","year":"2019","unstructured":"Humeres C, Frangogiannis NG (2019) Fibroblasts in the infarcted, remodeling, and failing heart. JACC Basic Transl Sci 4:449\u2013467. https:\/\/doi.org\/10.1016\/j.jacbts.2019.02.006","journal-title":"JACC Basic Transl Sci"},{"key":"1036_CR32","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.molimm.2021.04.004","volume":"135","author":"T K\u00e4ser","year":"2021","unstructured":"K\u00e4ser T (2021) Swine as biomedical animal model for T-cell research\u2014Success and potential for transmittable and non-transmittable human diseases. Mol Immunol 135:95\u2013115. https:\/\/doi.org\/10.1016\/j.molimm.2021.04.004","journal-title":"Mol Immunol"},{"key":"1036_CR33","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/BF01908144","volume":"79","author":"HH Klein","year":"1984","unstructured":"Klein HH, Schubothe M, Nebendahl K, Kreuzer H (1984) Temporal and spatial development of infarcts in porcine hearts. Basic Res Cardiol 79:440\u2013447. https:\/\/doi.org\/10.1007\/BF01908144","journal-title":"Basic Res Cardiol"},{"key":"1036_CR34","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/cvr\/cvac062","volume":"119","author":"P Kleinbongard","year":"2023","unstructured":"Kleinbongard P, Lieder H, Skyschally A, Heusch G (2023) No sex-related differences in infarct size, no-reflow, and protection by ischemic pre-conditioning in G\u00f6ttingen minipigs. Cardiovasc Res 119:561\u2013570. https:\/\/doi.org\/10.1093\/cvr\/cvac062","journal-title":"Cardiovasc Res"},{"key":"1036_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.992653","author":"V Kumar","year":"2022","unstructured":"Kumar V, Prabhu SD, Bansal SS (2022) CD4+ T lymphocytes exhibit biphasic kinetics post-myocardial infarction. Front Cardiovasc Med. https:\/\/doi.org\/10.3389\/fcvm.2022.992653","journal-title":"Front Cardiovasc Med"},{"key":"1036_CR36","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/s41586-022-05060-x","volume":"608","author":"C Kuppe","year":"2022","unstructured":"Kuppe C, Ramirez Flores RO, Li Z, Hayat S, Levinson RT, Liao X, Hannani MT, Tanevski J, W\u00fcnnemann F, Nagai JS, Halder M, Schumacher D, Menzel S, Sch\u00e4fer G, Hoeft K, Cheng M, Ziegler S, Zhang X, Peisker F, Kaesler N, Saritas T, Xu Y, Kassner A, Gummert J, Morshuis M, Amrute J, Veltrop RJA, Boor P, Klingel K, Van Laake LW, Vink A, Hoogenboezem RM, Bindels EMJ, Schurgers L, Sattler S, Schapiro D, Schneider RK, Lavine K, Milting H, Costa IG, Saez-Rodriguez J, Kramann R (2022) Spatial multi-omic map of human myocardial infarction. Nature 608:766\u2013777. https:\/\/doi.org\/10.1038\/s41586-022-05060-x","journal-title":"Nature"},{"key":"1036_CR37","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1093\/eurheartj\/eht331","volume":"35","author":"AM Van Der Laan","year":"2014","unstructured":"Van Der Laan AM, Ter Horst EN, Delewi R, Begieneman MPV, Krijnen PAJ, Hirsch A, Lavaei M, Nahrendorf M, Horrevoets AJ, Niessen HWM, Piek JJ (2014) Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir. Eur Heart J 35:376\u2013385. https:\/\/doi.org\/10.1093\/eurheartj\/eht331","journal-title":"Eur Heart J"},{"key":"1036_CR38","first-page":"432","volume":"53","author":"PP Lelovas","year":"2014","unstructured":"Lelovas PP, Kostomitsopoulos NG, Xanthos TT (2014) A comparative anatomic and physiologic overview of the porcine heart. J Am Assoc Lab Anim Sci 53:432\u2013438","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"1036_CR39","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1084\/jem.20111009","volume":"209","author":"F Leuschner","year":"2012","unstructured":"Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M (2012) Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med 209:123\u2013137. https:\/\/doi.org\/10.1084\/jem.20111009","journal-title":"J Exp Med"},{"key":"1036_CR40","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.jacc.2011.10.863","volume":"59","author":"Y-H Liao","year":"2012","unstructured":"Liao Y-H, Xia N, Zhou S-F, Tang T-T, Yan X-X, Lv B-J, Nie S-F, Wang J, Iwakura Y, Xiao H, Yuan J, Jevallee H, Wei F, Shi G-P, Cheng X (2012) Interleukin-17A contributes to myocardial ischemia\/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration. J Am Coll Cardiol 59:420\u2013429. https:\/\/doi.org\/10.1016\/j.jacc.2011.10.863","journal-title":"J Am Coll Cardiol"},{"key":"1036_CR41","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao Y, Smyth GK, Shi W (2014) featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30:923\u2013930. https:\/\/doi.org\/10.1093\/bioinformatics\/btt656","journal-title":"Bioinformatics"},{"key":"1036_CR42","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon A, Birger C, Thorvaldsd\u00f3ttir H, Ghandi M, Mesirov JP, Tamayo P (2015) The molecular signatures database hallmark gene set collection. Cell Syst 1:417\u2013425. https:\/\/doi.org\/10.1016\/j.cels.2015.12.004","journal-title":"Cell Syst"},{"key":"1036_CR43","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1161\/CIRCRESAHA.118.313859","volume":"123","author":"HR Lieder","year":"2018","unstructured":"Lieder HR, Kleinbongard P, Skyschally A, Hagelschuer H, Chilian WM, Heusch G (2018) Vago-splenic axis in signal transduction of remote ischemic preconditioning in pigs and rats. Circ Res 123:1152\u20131163. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313859","journal-title":"Circ Res"},{"key":"1036_CR44","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/cvr\/cvu062","volume":"102","author":"S Van Linthout","year":"2014","unstructured":"Van Linthout S, Miteva K, Tschope C (2014) Crosstalk between fibroblasts and inflammatory cells. Cardiovasc Res 102:258\u2013269. https:\/\/doi.org\/10.1093\/cvr\/cvu062","journal-title":"Cardiovasc Res"},{"key":"1036_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12917-019-1837-5","volume":"15","author":"E L\u00f3pez","year":"2019","unstructured":"L\u00f3pez E, S\u00e1nchez-Margallo FM, \u00c1lvarez V, Bl\u00e1zquez R, Marinaro F, Abad A, Mart\u00edn H, B\u00e1ez C, Blanco V, Cris\u00f3stomo V, Casado JG (2019) Identification of very early inflammatory markers in a porcine myocardial infarction model. BMC Vet Res 15:1\u20138. https:\/\/doi.org\/10.1186\/s12917-019-1837-5","journal-title":"BMC Vet Res"},{"key":"1036_CR46","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s00395-023-01000-6","volume":"118","author":"A Lother","year":"2023","unstructured":"Lother A, Kohl P (2023) The heterocellular heart: identities, interactions, and implications for cardiology. Basic Res Cardiol 118:30. https:\/\/doi.org\/10.1007\/s00395-023-01000-6","journal-title":"Basic Res Cardiol"},{"key":"1036_CR47","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8","journal-title":"Genome Biol"},{"key":"1036_CR48","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/s12967-015-0670-2","volume":"13","author":"TP Ludvigsen","year":"2015","unstructured":"Ludvigsen TP, Kirk RK, Christoffersen B\u00d8, Pedersen HD, Martinussen T, Kildegaard J, Heegaard PMH, Lykkesfeldt J, Olsen LH (2015) G\u00f6ttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals. J Transl Med 13:312. https:\/\/doi.org\/10.1186\/s12967-015-0670-2","journal-title":"J Transl Med"},{"key":"1036_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scitranslmed.abd5758","volume":"13","author":"JK Lunney","year":"2021","unstructured":"Lunney JK, Van Goor A, Walker KE, Hailstock T, Franklin J, Dai C (2021) Importance of the pig as a human biomedical model. Sci Transl Med 13:1\u201320. https:\/\/doi.org\/10.1126\/scitranslmed.abd5758","journal-title":"Sci Transl Med"},{"key":"1036_CR50","doi-asserted-by":"publisher","unstructured":"Martin M (2011) Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J 17:10 https:\/\/doi.org\/10.14806\/ej.17.1.200","DOI":"10.14806\/ej.17.1.200"},{"key":"1036_CR51","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00428-019-02662-1","volume":"476","author":"K Michaud","year":"2020","unstructured":"Michaud K, Basso C, D\u2019Amati G, Giordano C, Kholov\u00e1 I, Preston SD, Rizzo S, Sabatasso S, Sheppard MN, Vink A, van der Wal AC (2020) Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification. Virchows Arch 476:179\u2013194. https:\/\/doi.org\/10.1007\/s00428-019-02662-1","journal-title":"Virchows Arch"},{"key":"1036_CR52","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1084\/jem.20070885","volume":"204","author":"M Nahrendorf","year":"2007","unstructured":"Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ (2007) The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 204:3037\u20133047. https:\/\/doi.org\/10.1084\/jem.20070885","journal-title":"J Exp Med"},{"key":"1036_CR53","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s00441-020-03206-9","volume":"380","author":"R Pabst","year":"2020","unstructured":"Pabst R (2020) The pig as a model for immunology research. Cell Tissue Res 380:287\u2013304. https:\/\/doi.org\/10.1007\/s00441-020-03206-9","journal-title":"Cell Tissue Res"},{"key":"1036_CR54","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz336","author":"C Peet","year":"2019","unstructured":"Peet C, Ivetic A, Bromage DI, Shah AM (2019) Cardiac monocytes and macrophages after myocardial infarction. Cardiovasc Res. https:\/\/doi.org\/10.1093\/cvr\/cvz336","journal-title":"Cardiovasc Res"},{"key":"1036_CR55","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jim.2007.01.003","volume":"321","author":"C P\u00e9rez","year":"2007","unstructured":"P\u00e9rez C, Moreno S, Summerfield A, Domenech N, Alvarez B, Correa C, Alonso F, Ezquerra A, Dom\u00ednguez J, Revilla C (2007) Characterisation of porcine bone marrow progenitor cells identified by the anti-c-kit (CD117) monoclonal antibody 2B8\/BM. J Immunol Methods 321:70\u201379. https:\/\/doi.org\/10.1016\/j.jim.2007.01.003","journal-title":"J Immunol Methods"},{"key":"1036_CR56","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1051\/vetres:2008030","volume":"39","author":"L Piriou-Guzylack","year":"2008","unstructured":"Piriou-Guzylack L, Salmon H (2008) Membrane markers of the immune cells in swine: an update. Vet Res 39:54. https:\/\/doi.org\/10.1051\/vetres:2008030","journal-title":"Vet Res"},{"key":"1036_CR57","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13860","volume":"53","author":"M Radike","year":"2023","unstructured":"Radike M, Sutelman P, Ben-Aicha S, Guti\u00e9rrez M, Mendieta G, Alcover S, Casan\u00ed L, Arderiu G, Borrell-Pages M, Padr\u00f3 T, Badimon L, Vilahur G (2023) A comprehensive and longitudinal cardiac magnetic resonance imaging study of the impact of coronary ischemia duration on myocardial damage in a highly translatable animal model. Eur J Clin Invest 53:e13860. https:\/\/doi.org\/10.1111\/eci.13860","journal-title":"Eur J Clin Invest"},{"key":"1036_CR58","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00395-021-00897-1","volume":"116","author":"M Rao","year":"2021","unstructured":"Rao M, Wang X, Guo G, Wang L, Chen S, Yin P, Chen K, Chen L, Zhang Z, Chen X, Hu X, Hu S, Song J (2021) Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level. Basic Res Cardiol 116:55. https:\/\/doi.org\/10.1007\/s00395-021-00897-1","journal-title":"Basic Res Cardiol"},{"key":"1036_CR59","doi-asserted-by":"publisher","first-page":"4922","DOI":"10.1172\/JCI123859","volume":"129","author":"M Rieckmann","year":"2019","unstructured":"Rieckmann M, Delgobo M, Gaal C, B\u00fcchner L, Steinau P, Reshef D, Gil-Cruz C, ter Horst EN, Kircher M, Reiter T, Heinze KG, Niessen HWM, Krijnen PAJ, van der Laan AM, Piek JJ, Koch C, Wester H, Lapa C, Bauer WR, Ludewig B, Friedman N, Frantz S, Hofmann U, Ramos GC (2019) Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses. J Clin Invest 129:4922\u20134936. https:\/\/doi.org\/10.1172\/JCI123859","journal-title":"J Clin Invest"},{"key":"1036_CR60","doi-asserted-by":"publisher","unstructured":"Saalm\u00fcller A, Gerner W (2016) The immune system of swine. In: Ratcliffe MJH (ed) Encyclopedia of immunobiology. Academic Press, Cambridge, pp 538\u2013548 doi:https:\/\/doi.org\/10.1016\/B978-0-12-374279-7.12019-3","DOI":"10.1016\/B978-0-12-374279-7.12019-3"},{"key":"1036_CR61","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1038\/s41467-021-21737-9","volume":"12","author":"I Santos-Zas","year":"2021","unstructured":"Santos-Zas I, Lemari\u00e9 J, Zlatanova I, Cachanado M, Seghezzi J-C, Benamer H, Goube P, Vandestienne M, Cohen R, Ezzo M, Duval V, Zhang Y, Su J-B, Biz\u00e9 A, Sambin L, Bonnin P, Branchereau M, Heymes C, Tanchot C, Vilar J, Delacroix C, Hulot J-S, Cochain C, Bruneval P, Danchin N, Tedgui A, Mallat Z, Simon T, Ghaleh B, Silvestre J-S, Ait-Oufella H (2021) Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling. Nat Commun 12:1483. https:\/\/doi.org\/10.1038\/s41467-021-21737-9","journal-title":"Nat Commun"},{"key":"1036_CR62","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.dci.2018.01.018","volume":"84","author":"CA Sautter","year":"2018","unstructured":"Sautter CA, Auray G, Python S, Liniger M, Summerfield A (2018) Phenotypic and functional modulations of porcine macrophages by interferons and interleukin-4. Dev Comp Immunol 84:181\u2013192. https:\/\/doi.org\/10.1016\/j.dci.2018.01.018","journal-title":"Dev Comp Immunol"},{"key":"1036_CR63","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez J-Y, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676\u2013682. https:\/\/doi.org\/10.1038\/nmeth.2019","journal-title":"Nat Methods"},{"key":"1036_CR64","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s41684-021-00909-6","volume":"51","author":"D Sch\u00fcttler","year":"2022","unstructured":"Sch\u00fcttler D, Tomsits P, Bleyer C, Vlcek J, Pauly V, Hesse N, Sinner M, Merkus D, Hamers J, K\u00e4\u00e4b S, Clauss S (2022) A practical guide to setting up pig models for cardiovascular catheterization, electrophysiological assessment and heart disease research. Lab Anim (NY) 51:46\u201367. https:\/\/doi.org\/10.1038\/s41684-021-00909-6","journal-title":"Lab Anim (NY)"},{"key":"1036_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2016.00832","volume":"7","author":"H Singleton","year":"2016","unstructured":"Singleton H, Graham SP, Bodman-Smith KB, Frossard JP, Steinbach F (2016) Establishing porcine monocyte-derived macrophage and dendritic cell systems for studying the interaction with PRRSV-1. Front Microbiol 7:1\u201315. https:\/\/doi.org\/10.3389\/fmicb.2016.00832","journal-title":"Front Microbiol"},{"key":"1036_CR66","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.dci.2012.10.010","volume":"39","author":"M Sinkora","year":"2013","unstructured":"Sinkora M, Stepanova K, Sinkorova J (2013) Different anti-CD21 antibodies can be used to discriminate developmentally and functionally different subsets of B lymphocytes in circulation of pigs. Dev Comp Immunol 39:409\u2013418. https:\/\/doi.org\/10.1016\/j.dci.2012.10.010","journal-title":"Dev Comp Immunol"},{"key":"1036_CR67","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci 102:15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102","journal-title":"Proc Natl Acad Sci"},{"key":"1036_CR68","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0022-1759(03)00273-4","volume":"280","author":"A Summerfield","year":"2003","unstructured":"Summerfield A, Horn MP, Lozano G, Carrasco CP, Atze K, McCullough K (2003) C-kit positive porcine bone marrow progenitor cells identified and enriched using recombinant stem cell factor. J Immunol Methods 280:113\u2013123. https:\/\/doi.org\/10.1016\/S0022-1759(03)00273-4","journal-title":"J Immunol Methods"},{"key":"1036_CR69","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1056\/NEJMoa063842","volume":"355","author":"G Suntharalingam","year":"2006","unstructured":"Suntharalingam G, Perry MR, Ward S, Brett SJ, Castello-Cortes A, Brunner MD, Panoskaltsis N (2006) Cytokine storm in a Phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 355:1018\u20131028. https:\/\/doi.org\/10.1056\/NEJMoa063842","journal-title":"N Engl J Med"},{"key":"1036_CR70","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Gable AL, Fang T, Doncheva NT, Pyysalo S, Bork P, Jensen LJ, von Mering C (2023) The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51:D638\u2013D646. https:\/\/doi.org\/10.1093\/nar\/gkac1000","journal-title":"Nucleic Acids Res"},{"key":"1036_CR71","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1177\/0963689718817477","volume":"28","author":"S Tohyama","year":"2019","unstructured":"Tohyama S, Kobayashi E (2019) Age-appropriateness of porcine models used for cell transplantation. Cell Transplant 28:224\u2013228. https:\/\/doi.org\/10.1177\/0963689718817477","journal-title":"Cell Transplant"},{"key":"1036_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.916429","volume":"9","author":"D Tu","year":"2022","unstructured":"Tu D, Ma C, Zeng Z, Xu Q, Guo Z, Song X, Zhao X (2022) Identification of hub genes and transcription factor regulatory network for heart failure using RNA-seq data and robust rank aggregation analysis. Front Cardiovasc Med 9:916429. https:\/\/doi.org\/10.3389\/fcvm.2022.916429","journal-title":"Front Cardiovasc Med"},{"key":"1036_CR73","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.4049\/jimmunol.2100174","volume":"207","author":"S Uehlein","year":"2021","unstructured":"Uehlein S, Ding X, Fl\u00f6\u00dfer J, Schmidt S, Steitz J, Bille M, Schnitter F, Baltes S, Saalm\u00fcller A, Gerner W, Herrmann T, Frey A, Kerkau T, Hofmann U, Beyersdorf N (2021) Human-like response of pig T cells to superagonistic anti-CD28 monoclonal antibodies. J Immunol 207:2473\u20132488. https:\/\/doi.org\/10.4049\/jimmunol.2100174","journal-title":"J Immunol"},{"key":"1036_CR74","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.yjmcc.2010.12.021","volume":"50","author":"G Vilahur","year":"2011","unstructured":"Vilahur G, Juan-Babot O, Pe\u00f1a E, O\u00f1ate B, Casan\u00ed L, Badimon L (2011) Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. J Mol Cell Cardiol 50:522\u2013533. https:\/\/doi.org\/10.1016\/j.yjmcc.2010.12.021","journal-title":"J Mol Cell Cardiol"},{"key":"1036_CR75","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.mex.2015.02.007","volume":"2","author":"B Vogel","year":"2015","unstructured":"Vogel B, Siebert H, Hofmann U, Frantz S (2015) Determination of collagen content within picrosirius red stained paraffin-embedded tissue sections using fluorescence microscopy. MethodsX 2:124\u2013134. https:\/\/doi.org\/10.1016\/j.mex.2015.02.007","journal-title":"MethodsX"},{"key":"1036_CR76","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1161\/CIRCULATIONAHA.118.036053","volume":"139","author":"Y Wang","year":"2019","unstructured":"Wang Y, Dembowsky K, Chevalier E, St\u00fcve P, Korf-Klingebiel M, Lochner M, Napp LC, Frank H, Brinkmann E, Kanwischer A, Bauersachs J, Gy\u00f6ngy\u00f6si M, Sparwasser T, Wollert KC (2019) C-X-C motif chemokine receptor 4 blockade promotes tissue repair after myocardial infarction by enhancing regulatory T cell mobilization and immune-regulatory function. Circulation 139:1798\u20131812. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.118.036053","journal-title":"Circulation"},{"key":"1036_CR77","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.ijcard.2015.11.078","volume":"203","author":"Y Wang","year":"2016","unstructured":"Wang Y, Xie Y, Ma H, Su S, Wang Y, Wang J, Xiang M (2016) Regulatory T lymphocytes in myocardial infarction: a promising new therapeutic target. Int J Cardiol 203:923\u2013928. https:\/\/doi.org\/10.1016\/j.ijcard.2015.11.078","journal-title":"Int J Cardiol"},{"key":"1036_CR78","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1161\/CIRCRESAHA.115.303895","volume":"115","author":"J Weirather","year":"2014","unstructured":"Weirather J, Hofmann UDW, Beyersdorf N, Ramos GC, Vogel B, Frey A, Ertl G, Kerkau T, Frantz S (2014) Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte\/macrophage differentiation. Circ Res 115:55\u201367. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.303895","journal-title":"Circ Res"},{"key":"1036_CR79","first-page":"868","volume":"145","author":"IEMG Willems","year":"1994","unstructured":"Willems IEMG, Havenith MG, De Mey JGR, Daemen MJAP (1994) The alpha-smooth muscle actin-positive cells in healing human myocardial scars. Am J Pathol 145:868\u2013875","journal-title":"Am J Pathol"},{"key":"1036_CR80","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41569-022-00701-0","volume":"19","author":"A Wong","year":"2022","unstructured":"Wong A, Hamidzada H, Epelman S (2022) A cardioimmunologist\u2019s toolkit: genetic tools to dissect immune cells in cardiac disease. Nat Rev Cardiol 19:395\u2013413. https:\/\/doi.org\/10.1038\/s41569-022-00701-0","journal-title":"Nat Rev Cardiol"},{"key":"1036_CR81","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1161\/CIRCULATIONAHA.120.046789","volume":"142","author":"N Xia","year":"2020","unstructured":"Xia N, Lu Y, Gu M, Li N, Liu M, Jiao J, Zhu Z, Li J, Li D, Tang T, Lv B, Nie S, Zhang M, Liao M, Liao Y, Yang X, Cheng X (2020) A unique population of regulatory T cells in heart potentiates cardiac protection from myocardial infarction. Circulation 142:1956\u20131973. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.120.046789","journal-title":"Circulation"},{"key":"1036_CR82","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s00395-023-01014-0","volume":"118","author":"D Xie","year":"2023","unstructured":"Xie D, Guo H, Li M, Jia L, Zhang H, Liang D, Wu N, Yang Z, Tian Y (2023) Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia\/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion. Basic Res Cardiol 118:44. https:\/\/doi.org\/10.1007\/s00395-023-01014-0","journal-title":"Basic Res Cardiol"},{"key":"1036_CR83","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00395-023-00981-8","volume":"118","author":"J Xie","year":"2023","unstructured":"Xie J, Jiang L, Wang J, Yin Y, Wang R, Du L, Chen T, Ni Z, Qiao S, Gong H, Xu B, Xu Q (2023) Multilineage contribution of CD34+ cells in cardiac remodeling after ischemia\/reperfusion injury. Basic Res Cardiol 118:17. https:\/\/doi.org\/10.1007\/s00395-023-00981-8","journal-title":"Basic Res Cardiol"},{"key":"1036_CR84","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2013.04.023","volume":"62","author":"X Yan","year":"2013","unstructured":"Yan X, Anzai A, Katsumata Y, Matsuhashi T, Ito K, Endo J, Yamamoto T, Takeshima A, Shinmura K, Shen W, Fukuda K, Sano M (2013) Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction. J Mol Cell Cardiol 62:24\u201335. https:\/\/doi.org\/10.1016\/j.yjmcc.2013.04.023","journal-title":"J Mol Cell Cardiol"},{"key":"1036_CR85","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.004408","volume":"1","author":"X Yan","year":"2012","unstructured":"Yan X, Shichita T, Katsumata Y, Matsuhashi T, Ito H, Ito K, Anzai A, Endo J, Tamura Y, Kimura K, Fujita J, Shinmura K, Shen W, Yoshimura A, Fukuda K, Sano M (2012) Deleterious effect of the IL-23\/IL-17A axis and \u03b3\u03b4T cells on left-ventricular remodeling after myocardial infarction. J Am Heart Assoc 1:e004408. https:\/\/doi.org\/10.1161\/JAHA.112.004408","journal-title":"J Am Heart Assoc"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-024-01036-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-024-01036-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-024-01036-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T04:06:38Z","timestamp":1717128398000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-024-01036-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":85,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["1036"],"URL":"https:\/\/doi.org\/10.1007\/s00395-024-01036-2","relation":{},"ISSN":["1435-1803"],"issn-type":[{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,15]]},"assertion":[{"value":"23 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Non-financial interests: S.F. is consulting editor and F.L. member of the editorial board of Basic Research in Cardiology. Both receive no compensation for their respective positions. Beyond that, the authors have no competing interests to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experiments have been approved by the appropriate animal welfare authority (Regierung von Unterfranken, W\u00fcrzburg, Germany; file number RUF-55.2.2-2532-2-1143-17 and Regierungspr\u00e4sidium Karlsruhe, Karlsruhe, Germany; file number A-8\/18). They have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments as well as with the Federation of European Laboratory Animal Science Associations (FELASA) guidelines. Digital light microscopic images of human tissue specimens routinely collected during autopsy were provided by the Institute of Pathology, University of W\u00fcrzburg, Germany, in fully anonymized form for retrospective analysis. We consulted with the ethics committee of the University of W\u00fcrzburg which confirmed that no ethical approval is required in this case.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}