{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T13:32:09Z","timestamp":1748957529310,"version":"3.37.3"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["PF 10\/014"],"award-info":[{"award-number":["PF 10\/014"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Life Science Research Partners VZW"},{"name":"CoBioRes NV"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"DOI":"10.1007\/s00395-024-01069-7","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T17:02:33Z","timestamp":1722531753000},"page":"795-806","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study"],"prefix":"10.1007","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-662X","authenticated-orcid":false,"given":"Ming","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Pokreisz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet","family":"Claus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Casazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde","family":"Gillijns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Caluw\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"De Petrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Belmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert","family":"Reyns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desire","family":"Collen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan P.","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"1069_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2020.104058","volume":"132","author":"UK Allahwala","year":"2020","unstructured":"Allahwala UK, Khachigian LM, Nour D, Ridiandres A, Billah M, Ward M, Weaver J, Bhindi R (2020) Recruitment and maturation of the coronary collateral circulation: current understanding and perspectives in arteriogenesis. Microvasc Res 132:104058. https:\/\/doi.org\/10.1016\/j.mvr.2020.104058","journal-title":"Microvasc Res"},{"key":"1069_CR2","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1046\/j.1538-7836.2003.00263.x","volume":"1","author":"M Autiero","year":"2003","unstructured":"Autiero M, Luttun A, Tjwa M, Carmeliet P (2003) Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders. J Thromb Haemost 1:1356\u20131370. https:\/\/doi.org\/10.1046\/j.1538-7836.2003.00263.x","journal-title":"J Thromb Haemost"},{"key":"1069_CR3","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1038\/sj.bjp.0706347","volume":"146","author":"L Bellik","year":"2005","unstructured":"Bellik L, Vinci MC, Filippi S, Ledda F, Parenti A (2005) Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia. Br J Pharmacol 146:568\u2013575. https:\/\/doi.org\/10.1038\/sj.bjp.0706347","journal-title":"Br J Pharmacol"},{"key":"1069_CR4","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1093\/eurheartj\/ehl446","volume":"28","author":"C Berry","year":"2007","unstructured":"Berry C, Balachandran KP, L\u2019Allier PL, Lesperance J, Bonan R, Oldroyd KG (2007) Importance of collateral circulation in coronary heart disease. Eur Heart J 28:278\u2013291. https:\/\/doi.org\/10.1093\/eurheartj\/ehl446","journal-title":"Eur Heart J"},{"key":"1069_CR5","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.2147\/IJN.S25175","volume":"6","author":"ZM Binsalamah","year":"2011","unstructured":"Binsalamah ZM, Paul A, Khan AA, Prakash S, Shum-Tim D (2011) Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model. Int J Nanomedicine 6:2667\u20132678. https:\/\/doi.org\/10.2147\/IJN.S25175","journal-title":"Int J Nanomedicine"},{"key":"1069_CR6","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/74651","volume":"6","author":"P Carmeliet","year":"2000","unstructured":"Carmeliet P (2000) Mechanisms of angiogenesis and arteriogenesis. Nat Med 6:389\u2013395. https:\/\/doi.org\/10.1038\/74651","journal-title":"Nat Med"},{"key":"1069_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.vph.2016.05.011","volume":"86","author":"L Claesson-Welsh","year":"2016","unstructured":"Claesson-Welsh L (2016) VEGF receptor signal transduction\u2014a brief update. Vascul Pharmacol 86:14\u201317. https:\/\/doi.org\/10.1016\/j.vph.2016.05.011","journal-title":"Vascul Pharmacol"},{"key":"1069_CR8","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1038\/ncomms1977","volume":"3","author":"MJ Cudmore","year":"2012","unstructured":"Cudmore MJ, Hewett PW, Ahmad S, Wang KQ, Cai M, Al-Ani B, Fujisawa T, Ma B, Sissaoui S, Ramma W, Miller MR, Newby DE, Gu Y, Barleon B, Weich H, Ahmed A (2012) The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis. Nat Commun 3:972. https:\/\/doi.org\/10.1038\/ncomms1977","journal-title":"Nat Commun"},{"key":"1069_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3858\/emm.2012.44.1.025","volume":"44","author":"S De Falco","year":"2012","unstructured":"De Falco S (2012) The discovery of placenta growth factor and its biological activity. Exp Mol Med 44:1\u20139. https:\/\/doi.org\/10.3858\/emm.2012.44.1.025","journal-title":"Exp Mol Med"},{"key":"1069_CR10","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011056","author":"M Dewerchin","year":"2012","unstructured":"Dewerchin M, Carmeliet P (2012) PlGF: a multitasking cytokine with disease-restricted activity. Cold Spring Harb Perspect Med. https:\/\/doi.org\/10.1101\/cshperspect.a011056","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1069_CR11","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.ehj.2004.03.005","volume":"25","author":"P Elsman","year":"2004","unstructured":"Elsman P, van Hof AW, de Boer MJ, Hoorntje JC, Suryapranata H, Dambrink JH, Zijlstra F, Zwolle Myocardial Infarction Study G (2004) Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary intervention. Eur Heart J 25:854\u2013858. https:\/\/doi.org\/10.1016\/j.ehj.2004.03.005","journal-title":"Eur Heart J"},{"key":"1069_CR12","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.cell.2007.08.038","volume":"131","author":"C Fischer","year":"2007","unstructured":"Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, Chorianopoulos E, Liesenborghs L, Koch M, De Mol M, Autiero M, Wyns S, Plaisance S, Moons L, van Rooijen N, Giacca M, Stassen JM, Dewerchin M, Collen D, Carmeliet P (2007) Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 131:463\u2013475. https:\/\/doi.org\/10.1016\/j.cell.2007.08.038","journal-title":"Cell"},{"key":"1069_CR13","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/gt.2012.17","volume":"19","author":"M Giacca","year":"2012","unstructured":"Giacca M, Zacchigna S (2012) VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond. Gene Ther 19:622\u2013629. https:\/\/doi.org\/10.1038\/gt.2012.17","journal-title":"Gene Ther"},{"key":"1069_CR14","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/nm0596-534","volume":"2","author":"FJ Giordano","year":"1996","unstructured":"Giordano FJ, Ping P, McKirnan MD, Nozaki S, DeMaria AN, Dillmann WH, Mathieu-Costello O, Hammond HK (1996) Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med 2:534\u2013539. https:\/\/doi.org\/10.1038\/nm0596-534","journal-title":"Nat Med"},{"key":"1069_CR15","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.amjcard.2010.11.003","volume":"107","author":"R Glaser","year":"2011","unstructured":"Glaser R, Peacock WF, Wu AH, Muller R, Mockel M, Apple FS (2011) Placental growth factor and B-type natriuretic peptide as independent predictors of risk from a multibiomarker panel in suspected acute coronary syndrome (Acute Risk and Related Outcomes Assessed With Cardiac Biomarkers [ARROW]) study. Am J Cardiol 107:821\u2013826. https:\/\/doi.org\/10.1016\/j.amjcard.2010.11.003","journal-title":"Am J Cardiol"},{"key":"1069_CR16","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/s41569-021-00506-7","volume":"18","author":"G Heusch","year":"2021","unstructured":"Heusch G (2021) Myocardial stunning and hibernation revisited. Nat Rev Cardiol 18:522\u2013536. https:\/\/doi.org\/10.1038\/s41569-021-00506-7","journal-title":"Nat Rev Cardiol"},{"key":"1069_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-022-00909-8","volume":"117","author":"G Heusch","year":"2022","unstructured":"Heusch G (2022) Coronary blood flow in heart failure: cause, consequence and bystander. Basic Res Cardiol 117:1. https:\/\/doi.org\/10.1007\/s00395-022-00909-8","journal-title":"Basic Res Cardiol"},{"key":"1069_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024872","volume":"6","author":"H Iwasaki","year":"2011","unstructured":"Iwasaki H, Kawamoto A, Tjwa M, Horii M, Hayashi S, Oyamada A, Matsumoto T, Suehiro S, Carmeliet P, Asahara T (2011) PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors. PLoS ONE 6:e24872. https:\/\/doi.org\/10.1371\/journal.pone.0024872","journal-title":"PLoS ONE"},{"key":"1069_CR19","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/j.1540-8191.2006.00296.x","volume":"21","author":"S Kolakowski Jr","year":"2006","unstructured":"Kolakowski S Jr, Berry MF, Atluri P, Grand T, Fisher O, Moise MA, Cohen J, Hsu V, Woo YJ (2006) Placental growth factor provides a novel local angiogenic therapy for ischemic cardiomyopathy. J Card Surg 21:559\u2013564. https:\/\/doi.org\/10.1111\/j.1540-8191.2006.00296.x","journal-title":"J Card Surg"},{"key":"1069_CR20","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2307\/2529876","volume":"38","author":"NM Laird","year":"1982","unstructured":"Laird NM, Ware JH (1982) Random-effects models for longitudinal data. Biometrics 38:963\u2013974","journal-title":"Biometrics"},{"key":"1069_CR21","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s00395-011-0200-1","volume":"106","author":"AD Lassaletta","year":"2011","unstructured":"Lassaletta AD, Chu LM, Sellke FW (2011) Therapeutic neovascularization for coronary disease: current state and future prospects. Basic Res Cardiol 106:897\u2013909. https:\/\/doi.org\/10.1007\/s00395-011-0200-1","journal-title":"Basic Res Cardiol"},{"key":"1069_CR22","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jacc.2005.08.063","volume":"47","author":"T Lenderink","year":"2006","unstructured":"Lenderink T, Heeschen C, Fichtlscherer S, Dimmeler S, Hamm CW, Zeiher AM, Simoons ML, Boersma E, Investigators C (2006) Elevated placental growth factor levels are associated with adverse outcomes at four-year follow-up in patients with acute coronary syndromes. J Am Coll Cardiol 47:307\u2013311. https:\/\/doi.org\/10.1016\/j.jacc.2005.08.063","journal-title":"J Am Coll Cardiol"},{"key":"1069_CR23","doi-asserted-by":"publisher","first-page":"H812","DOI":"10.1152\/ajpheart.00335.2017","volume":"314","author":"ML Lindsey","year":"2018","unstructured":"Lindsey ML, Bolli R, Canty JM Jr, Du XJ, Frangogiannis NG, Frantz S, Gourdie RG, Holmes JW, Jones SP, Kloner RA, Lefer DJ, Liao R, Murphy E, Ping P, Przyklenk K, Recchia FA, Schwartz Longacre L, Ripplinger CM, Van Eyk JE, Heusch G (2018) Guidelines for experimental models of myocardial ischemia and infarction. Am J Physiol Heart Circ Physiol 314:H812\u2013H838. https:\/\/doi.org\/10.1152\/ajpheart.00335.2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1069_CR24","doi-asserted-by":"publisher","first-page":"H885","DOI":"10.1152\/ajpheart.00587.2012","volume":"304","author":"X Liu","year":"2013","unstructured":"Liu X, Claus P, Wu M, Reyns G, Verhamme P, Pokreisz P, Vandenwijngaert S, Dubois C, Vanhaecke J, Verbeken E, Bogaert J, Janssens S (2013) Placental growth factor increases regional myocardial blood flow and contractile function in chronic myocardial ischemia. Am J Physiol Heart Circ Physiol 304:H885-894. https:\/\/doi.org\/10.1152\/ajpheart.00587.2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1069_CR25","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"1069_CR26","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/s0008-6363(98)00136-9","volume":"40","author":"JJ Lopez","year":"1998","unstructured":"Lopez JJ, Laham RJ, Stamler A, Pearlman JD, Bunting S, Kaplan A, Carrozza JP, Sellke FW, Simons M (1998) VEGF administration in chronic myocardial ischemia in pigs. Cardiovasc Res 40:272\u2013281. https:\/\/doi.org\/10.1016\/s0008-6363(98)00136-9","journal-title":"Cardiovasc Res"},{"key":"1069_CR27","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/nm731","volume":"8","author":"A Luttun","year":"2002","unstructured":"Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy JA, Hooper A, Priller J, De Klerck B, Compernolle V, Daci E, Bohlen P, Dewerchin M, Herbert JM, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak HF, Hicklin DJ, Carmeliet P (2002) Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 8:831\u2013840. https:\/\/doi.org\/10.1038\/nm731","journal-title":"Nat Med"},{"key":"1069_CR28","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jcmg.2009.06.016","volume":"3","author":"PG Masci","year":"2010","unstructured":"Masci PG, Ganame J, Strata E, Desmet W, Aquaro GD, Dymarkowski S, Valenti V, Janssens S, Lombardi M, Van de Werf F, L\u2019Abbate A, Bogaert J (2010) Myocardial salvage by CMR correlates with LV remodeling and early ST-segment resolution in acute myocardial infarction. JACC Cardiovasc Imaging 3:45\u201351. https:\/\/doi.org\/10.1016\/j.jcmg.2009.06.016","journal-title":"JACC Cardiovasc Imaging"},{"key":"1069_CR29","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1161\/CIR.0000000000000152","volume":"131","author":"D Mozaffarian","year":"2015","unstructured":"Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Willey JZ, Woo D, Yeh RW, Turner MB, American Heart Association Statistics C, Stroke Statistics S (2015) Heart disease and stroke statistics\u20132015 update: a report from the American Heart Association. Circulation 131:e29-322. https:\/\/doi.org\/10.1161\/CIR.0000000000000152","journal-title":"Circulation"},{"key":"1069_CR30","doi-asserted-by":"publisher","first-page":"25646","DOI":"10.1016\/S0021-9258(18)47298-5","volume":"269","author":"JE Park","year":"1994","unstructured":"Park JE, Chen HH, Winer J, Houck KA, Ferrara N (1994) Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1\/KDR. J Biol Chem 269:25646\u201325654","journal-title":"J Biol Chem"},{"key":"1069_CR31","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.cardfail.2011.03.004","volume":"17","author":"EC Perin","year":"2011","unstructured":"Perin EC, Silva GV, Vela DC, Zheng Y, Baimbridge F, Gahremanpour A, Quan X, Hahn W, Kim J, Wood K, Kitamura M (2011) Human hepatocyte growth factor (VM202) gene therapy via transendocardial injection in a pig model of chronic myocardial ischemia. J Card Fail 17:601\u2013611. https:\/\/doi.org\/10.1016\/j.cardfail.2011.03.004","journal-title":"J Card Fail"},{"key":"1069_CR32","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.atherosclerosis.2006.10.038","volume":"196","author":"K Pilarczyk","year":"2008","unstructured":"Pilarczyk K, Sattler KJE, Galili O, Versari D, Olson ML, Meyer FB, Zhu XY, Lerman LO, Lerman A (2008) Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization. Atherosclerosis 196:333\u2013340. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2006.10.038","journal-title":"Atherosclerosis"},{"key":"1069_CR33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/cvr\/cvp380","volume":"86","author":"C Roncal","year":"2010","unstructured":"Roncal C, Buysschaert I, Gerdes N, Georgiadou M, Ovchinnikova O, Fischer C, Stassen JM, Moons L, Collen D, De Bock K, Hansson GK, Carmeliet P (2010) Short-term delivery of anti-PlGF antibody delays progression of atherosclerotic plaques to vulnerable lesions. Cardiovasc Res 86:29\u201336. https:\/\/doi.org\/10.1093\/cvr\/cvp380","journal-title":"Cardiovasc Res"},{"key":"1069_CR34","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/s0735-1097(00)01144-x","volume":"37","author":"K Sato","year":"2001","unstructured":"Sato K, Wu T, Laham RJ, Johnson RB, Douglas P, Li J, Sellke FW, Bunting S, Simons M, Post MJ (2001) Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. J Am Coll Cardiol 37:616\u2013623. https:\/\/doi.org\/10.1016\/s0735-1097(00)01144-x","journal-title":"J Am Coll Cardiol"},{"key":"1069_CR35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00395-008-0760-x","volume":"104","author":"W Schaper","year":"2009","unstructured":"Schaper W (2009) Collateral circulation: past and present. Basic Res Cardiol 104:5\u201321. https:\/\/doi.org\/10.1007\/s00395-008-0760-x","journal-title":"Basic Res Cardiol"},{"key":"1069_CR36","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139167826","volume-title":"Scaling, why is animal size so important?","author":"K Schmidt-Nielsen","year":"1984","unstructured":"Schmidt-Nielsen K, Knut S-N (1984) Scaling, why is animal size so important? Cambridge University Press, Cambridge"},{"key":"1069_CR37","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/nrm.2016.87","volume":"17","author":"M Simons","year":"2016","unstructured":"Simons M, Gordon E, Claesson-Welsh L (2016) Mechanisms and regulation of endothelial VEGF receptor signalling. Nat Rev Mol Cell Biol 17:611\u2013625. https:\/\/doi.org\/10.1038\/nrm.2016.87","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1069_CR38","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1517\/14656560903439737","volume":"11","author":"NR Sodha","year":"2010","unstructured":"Sodha NR, Chu LM, Boodhwani M, Sellke FW (2010) Pharmacotherapy for end-stage coronary artery disease. Expert Opin Pharmacother 11:207\u2013213. https:\/\/doi.org\/10.1517\/14656560903439737","journal-title":"Expert Opin Pharmacother"},{"key":"1069_CR39","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1253\/circj.cj-08-1067","volume":"73","author":"Y Takeda","year":"2009","unstructured":"Takeda Y, Uemura S, Iwama H, Imagawa K, Nishida T, Onoue K, Takemoto Y, Soeda T, Okayama S, Somekawa S, Ishigami K, Takaoka M, Kawata H, Kubo A, Horii M, Nakajima T, Saito Y (2009) Treatment with recombinant placental growth factor (PlGF) enhances both angiogenesis and arteriogenesis and improves survival after myocardial infarction. Circ J 73:1674\u20131682. https:\/\/doi.org\/10.1253\/circj.cj-08-1067","journal-title":"Circ J"},{"key":"1069_CR40","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s10741-017-9630-7","volume":"22","author":"H Thiagarajan","year":"2017","unstructured":"Thiagarajan H, Thiyagamoorthy U, Shanmugham I, Dharmalingam Nandagopal G, Kaliyaperumal A (2017) Angiogenic growth factors in myocardial infarction: a critical appraisal. Heart Fail Rev 22:665\u2013683. https:\/\/doi.org\/10.1007\/s10741-017-9630-7","journal-title":"Heart Fail Rev"},{"key":"1069_CR41","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1093\/ehjqcco\/qcac014","volume":"8","author":"A Timmis","year":"2022","unstructured":"Timmis A, Vardas P, Townsend N, Torbica A, Katus H, De Smedt D, Gale CP, Maggioni AP, Petersen SE, Huculeci R, Kazakiewicz D, Rubio VB, Ignatiuk B, Raisi-Estabragh Z, Pawlak A, Karagiannidis E, Treskes R, Gaita D, Beltrame JF, McConnachie A, Bardinet I, Graham I, Flather M, Elliott P, Mossialos EA, Weidinger F, Achenbach S (2022) European society of cardiology: cardiovascular disease statistics 2021: executive summary. Eur Heart J Qual Care Clin Outcomes 8:377\u2013382. https:\/\/doi.org\/10.1093\/ehjqcco\/qcac014","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"1069_CR42","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","volume":"141","author":"SS Virani","year":"2020","unstructured":"Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Shay CM, Spartano NL, Stokes A, Tirschwell DL, VanWagner LB, Tsao CW, American Heart Association Council on E, Prevention Statistics C, Stroke Statistics S (2020) Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation 141:e139\u2013e596. https:\/\/doi.org\/10.1161\/CIR.0000000000000757","journal-title":"Circulation"},{"key":"1069_CR43","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.ijcard.2015.10.177","volume":"203","author":"M Wu","year":"2016","unstructured":"Wu M, Claus P, Vanden Driessche N, Reyns G, Pokreisz P, Gillijns H, Caluwe E, Bogaert J, Collen D, Janssens S (2016) Placental growth factor 2\u2013A potential therapeutic strategy for chronic myocardial ischemia. Int J Cardiol 203:534\u2013542. https:\/\/doi.org\/10.1016\/j.ijcard.2015.10.177","journal-title":"Int J Cardiol"},{"key":"1069_CR44","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/cvr\/cvq257","volume":"89","author":"M Wu","year":"2011","unstructured":"Wu M, D\u2019Hooge J, Ganame J, Ferferieva V, Sipido KR, Maes F, Dymarkowski S, Bogaert J, Rademakers FE, Claus P (2011) Non-invasive characterization of the area-at-risk using magnetic resonance imaging in chronic ischaemia. Cardiovasc Res 89:166\u2013174. https:\/\/doi.org\/10.1093\/cvr\/cvq257","journal-title":"Cardiovasc Res"},{"key":"1069_CR45","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s12265-017-9742-4","volume":"10","author":"M Wu","year":"2017","unstructured":"Wu M, Pokreisz P, Swinnen M, Caluwe E, Gillijns H, Vanden Driessche N, Casazza A, Verbeken E, Collen D, Janssens S (2017) Sustained placental growth factor-2 treatment does not aggravate advanced atherosclerosis in ischemic cardiomyopathy. J Cardiovasc Transl Res 10:348\u2013358. https:\/\/doi.org\/10.1007\/s12265-017-9742-4","journal-title":"J Cardiovasc Transl Res"},{"key":"1069_CR46","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s11030-006-9027-3","volume":"10","author":"Y Yamazaki","year":"2006","unstructured":"Yamazaki Y, Morita T (2006) Molecular and functional diversity of vascular endothelial growth factors. Mol Divers 10:515\u2013527. https:\/\/doi.org\/10.1007\/s11030-006-9027-3","journal-title":"Mol Divers"},{"key":"1069_CR47","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1096\/fj.09-143180","volume":"24","author":"L Zentilin","year":"2010","unstructured":"Zentilin L, Puligadda U, Lionetti V, Zacchigna S, Collesi C, Pattarini L, Ruozi G, Camporesi S, Sinagra G, Pepe M, Recchia FA, Giacca M (2010) Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction. FASEB J 24:1467\u20131478. https:\/\/doi.org\/10.1096\/fj.09-143180","journal-title":"FASEB J"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-024-01069-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-024-01069-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-024-01069-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T14:03:43Z","timestamp":1728396223000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-024-01069-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":47,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["1069"],"URL":"https:\/\/doi.org\/10.1007\/s00395-024-01069-7","relation":{},"ISSN":["1435-1803"],"issn-type":[{"type":"electronic","value":"1435-1803"}],"subject":[],"published":{"date-parts":[[2024,8,1]]},"assertion":[{"value":"13 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors associated with a spin-off company CoBioRes NV had no influence on the blinded evaluation of the presented study. The other authors have declared that no conflict of interest exists.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}