{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:01:20Z","timestamp":1792807280462,"version":"4.5.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A long-standing aim in the setting of various pathologies including acute myocardial infarction, chronic kidney disease (CKD), and ischaemic stroke, has been to identify successful approaches to augment cellular and organ protection. Although the continual evolution and refinement of ideas over the past few decades has allowed the field to progress, we are yet to realise successful clinical translation of this concept. The 12th Hatter Cardiovascular Workshop identified a number of important points and key questions for future research relating to cardio- and neuro-protection and interorgan communication. Specific topics that were discussed include the \u2018cardio-metabolic-renal\u2019 axis of organ protection, the parasympathetic signalling hypothesis, the role of the coronary microvasculature in myocardial infarction, the RISK pathway of cardioprotection, extracellular vesicles and the way forward, the future for clinical studies of remote ischaemic conditioning, and new experimental models for cardio-oncology investigations.<\/jats:p>","DOI":"10.1007\/s00395-024-01094-6","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T11:04:24Z","timestamp":1734347064000},"page":"287-299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop"],"prefix":"10.1007","volume":"120","author":[{"given":"L.","family":"Pearce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gal\u00e1n-Arriola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Giesz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Golforoush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. V.","family":"Gourine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Heusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ibanez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Beikoghli","family":"Kalkhoran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lecour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lukhna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ntsekhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"Sack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Unwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vilahur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-9320","authenticated-orcid":false,"given":"D. M.","family":"Yellon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"1094_CR1","doi-asserted-by":"publisher","first-page":"S67","DOI":"10.1016\/j.yjmcc.2022.08.136","volume":"173","author":"C Abrahams","year":"2022","unstructured":"Abrahams C, Woudberg NJ, Kodogo V, Hadebe N, LeCour S (2022) Doxorubicin-induced cardiotoxicity is associated with a change in high density lipoprotein subclasses in a mouse breast cancer model. J Mol Cell Cardiol 173:S67. https:\/\/doi.org\/10.1016\/j.yjmcc.2022.08.136","journal-title":"J Mol Cell Cardiol"},{"key":"1094_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-024-01079-5","author":"MS Anker","year":"2024","unstructured":"Anker MS, Rashid AM, Butler J, Khan MS (2024) Cardiac wasting in patients with cancer. Basic Res Cardiol. https:\/\/doi.org\/10.1007\/s00395-024-01079-5","journal-title":"Basic Res Cardiol"},{"key":"1094_CR3","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1056\/NEJMoa2107038","volume":"385","author":"SD Anker","year":"2021","unstructured":"Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, B\u00f6hm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Pi\u00f1a IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M (2021) Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med 385:1451\u20131461. https:\/\/doi.org\/10.1056\/NEJMoa2107038","journal-title":"N Engl J Med"},{"key":"1094_CR4","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1113\/expphysiol.2012.064923","volume":"97","author":"M Basalay","year":"2012","unstructured":"Basalay M, Barsukevich V, Mastitskaya S, Mrochek A, Pernow J, Sj\u00f6quist PO, Ackland GL, Gourine AV, Gourine A (2012) Remote ischaemic pre- and delayed postconditioning: similar degree of cardioprotection but distinct mechanisms. Exp Physiol 97:908\u2013917. https:\/\/doi.org\/10.1113\/expphysiol.2012.064923","journal-title":"Exp Physiol"},{"key":"1094_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00395-018-0684-z","volume":"113","author":"MV Basalay","year":"2018","unstructured":"Basalay MV, Davidson SM, Gourine AV, Yellon DM (2018) Neural mechanisms in remote ischaemic conditioning in the heart and brain: mechanistic and translational aspects. Basic Res Cardiol 113:25. https:\/\/doi.org\/10.1007\/s00395-018-0684-z","journal-title":"Basic Res Cardiol"},{"key":"1094_CR6","doi-asserted-by":"crossref","unstructured":"Basalay MV, Korasak A, Gourine AV, Davidson SM, Yellon DM (2025) SGLT2 inhibition induces cardioprotection by increasing parasympathetic activity. Circulation Research (in press)","DOI":"10.1161\/CIRCRESAHA.124.324708"},{"key":"1094_CR7","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/cvr\/cvw216","volume":"112","author":"MV Basalay","year":"2016","unstructured":"Basalay MV, Mastitskaya S, Mrochek A, Ackland GL, Del Arroyo AG, Sanchez J, Sjoquist PO, Pernow J, Gourine AV, Gourine A (2016) Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning. Cardiovasc Res 112:669\u2013676. https:\/\/doi.org\/10.1093\/cvr\/cvw216","journal-title":"Cardiovasc Res"},{"key":"1094_CR8","doi-asserted-by":"publisher","first-page":"16874","DOI":"10.1038\/s41598-020-74046-4","volume":"10","author":"MV Basalay","year":"2020","unstructured":"Basalay MV, Wiart M, Chauveau F, Dumot C, Leon C, Amaz C, Bolbos R, Cash D, Kim E, Mechtouff L, Cho TH, Nighoghossian N, Davidson SM, Ovize M, Yellon DM (2020) Neuroprotection by remote ischemic conditioning in the setting of acute ischemic stroke: a preclinical two-centre study. Sci Rep 10:16874. https:\/\/doi.org\/10.1038\/s41598-020-74046-4","journal-title":"Sci Rep"},{"key":"1094_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-024-01086-6","author":"S Beikoghli Kalkhoran","year":"2024","unstructured":"Beikoghli Kalkhoran S, Basalay M, He Z, Golforoush P, Roper T, Caplin B, Salama AD, Davidson SM, Yellon DM (2024) Investigating the cause of cardiovascular dysfunction in chronic kidney disease: capillary rarefaction and inflammation may contribute to detrimental cardiovascular outcomes. Basic Res Cardiol. https:\/\/doi.org\/10.1007\/s00395-024-01086-6","journal-title":"Basic Res Cardiol"},{"key":"1094_CR10","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00395-022-00947-2","volume":"117","author":"RM Bell","year":"2022","unstructured":"Bell RM, Basalay M, Botker HE, Beikoghli Kalkhoran S, Carr RD, Cunningham J, Davidson SM, England TJ, Giesz S, Ghosh AK, Golforoush P, Gourine AV, Hausenloy DJ, Heusch G, Ibanez B, Kleinbongard P, Lecour S, Lukhna K, Ntsekhe M, Ovize M, Salama AD, Vilahur G, Walker JM, Yellon DM (2022) Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop. Basic Res Cardiol 117:39. https:\/\/doi.org\/10.1007\/s00395-022-00947-2","journal-title":"Basic Res Cardiol"},{"key":"1094_CR11","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00395-016-0558-1","volume":"111","author":"RM Bell","year":"2016","unstructured":"Bell RM, Botker HE, Carr RD, Davidson SM, Downey JM, Dutka DP, Heusch G, Ibanez B, Macallister R, Stoppe C, Ovize M, Redington A, Walker JM, Yellon DM (2016) 9th Hatter Biannual Meeting: position document on ischaemia\/reperfusion injury, conditioning and the ten commandments of cardioprotection. Basic Res Cardiol 111:41. https:\/\/doi.org\/10.1007\/s00395-016-0558-1","journal-title":"Basic Res Cardiol"},{"key":"1094_CR12","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jacc.2021.11.002","volume":"79","author":"C Berry","year":"2022","unstructured":"Berry C, Ibanez B (2022) Intramyocardial Hemorrhage: The Final Frontier for Preventing Heart Failure Post-Myocardial Infarction. J Am Coll Cardiol 79:49\u201351. https:\/\/doi.org\/10.1016\/j.jacc.2021.11.002","journal-title":"J Am Coll Cardiol"},{"key":"1094_CR13","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1177\/1074248420937871","volume":"25","author":"HE Botker","year":"2020","unstructured":"Botker HE (2020) The future of cardioprotection-pointing toward patients at elevated risk as the target populations. J Cardiovasc Pharmacol Ther 25:487\u2013493. https:\/\/doi.org\/10.1177\/1074248420937871","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"1094_CR14","doi-asserted-by":"publisher","first-page":"F125","DOI":"10.1152\/ajprenal.00145.2020","volume":"319","author":"J Cai","year":"2020","unstructured":"Cai J, Nash WT, Okusa MD (2020) Ultrasound for the treatment of acute kidney injury and other inflammatory conditions: a promising path toward noninvasive neuroimmune regulation. Am J Physiol Renal Physiol 319:F125-f138. https:\/\/doi.org\/10.1152\/ajprenal.00145.2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"1094_CR15","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1161\/circresaha.117.311170","volume":"121","author":"Z Chen","year":"2017","unstructured":"Chen Z, Venkat P, Seyfried D, Chopp M, Yan T, Chen J (2017) Brain-heart interaction: cardiac complications after stroke. Circ Res 121:451\u2013468. https:\/\/doi.org\/10.1161\/circresaha.117.311170","journal-title":"Circ Res"},{"key":"1094_CR16","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41573-022-00410-w","volume":"21","author":"L Cheng","year":"2022","unstructured":"Cheng L, Hill AF (2022) Therapeutically harnessing extracellular vesicles. Nat Rev Drug Discov 21:379\u2013399. https:\/\/doi.org\/10.1038\/s41573-022-00410-w","journal-title":"Nat Rev Drug Discov"},{"key":"1094_CR17","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.018076","author":"TSR da Costa","year":"2021","unstructured":"da Costa TSR, Urias U, Negrao MV, Jord\u00e3o CP, Passos CS, Gomes-Santos IL, Salemi VMC, Camargo AA, Brum PC, Oliveira EM, Hajjar LA, Chammas R, Filho RK, Negrao CE (2021) Breast cancer promotes cardiac dysfunction through deregulation of cardiomyocyte Ca(2+)-handling protein expression that is not reversed by exercise training. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/jaha.120.018076","journal-title":"J Am Heart Assoc"},{"key":"1094_CR18","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae147","author":"T Dalkara","year":"2024","unstructured":"Dalkara T, \u00d8stergaard L, Heusch G, Attwell D (2024) Pericytes in the brain and heart: functional roles and response to ischemia and reperfusion. Cardiovasc Res. https:\/\/doi.org\/10.1093\/cvr\/cvae147","journal-title":"Cardiovasc Res"},{"key":"1094_CR19","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1007\/s00125-020-05254-w","volume":"63","author":"G Daniele","year":"2020","unstructured":"Daniele G, Solis-Herrera C, Dardano A, Mari A, Tura A, Giusti L, Kurumthodathu JJ, Campi B, Saba A, Bianchi AM, Tregnaghi C, Egidi MF, Abdul-Ghani M, DeFronzo R, Del Prato S (2020) Increase in endogenous glucose production with SGLT2 inhibition is attenuated in individuals who underwent kidney transplantation and bilateral native nephrectomy. Diabetologia 63:2423\u20132433. https:\/\/doi.org\/10.1007\/s00125-020-05254-w","journal-title":"Diabetologia"},{"key":"1094_CR20","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1093\/cvr\/cvy314","volume":"115","author":"SM Davidson","year":"2019","unstructured":"Davidson SM, Andreadou I, Barile L, Birnbaum Y, Cabrera-Fuentes HA, Cohen MV, Downey JM, Girao H, Pagliaro P, Penna C, Pernow J, Preissner KT, Ferdinandy P (2019) Circulating blood cells and extracellular vesicles in acute cardioprotection. Cardiovasc Res 115:1156\u20131166. https:\/\/doi.org\/10.1093\/cvr\/cvy314","journal-title":"Cardiovasc Res"},{"key":"1094_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/cvr\/cvac031","volume":"119","author":"SM Davidson","year":"2023","unstructured":"Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsur M, Lacroix R, Lim SK, Mackman N, Mayr M, Menasch\u00e9 P, Nieuwland R, Sahoo S, Takov K, Thum T, Vader P, Wauben MHM, Witwer K, Sluijter JPG (2023) Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles. Cardiovasc Res 119:45\u201363. https:\/\/doi.org\/10.1093\/cvr\/cvac031","journal-title":"Cardiovasc Res"},{"key":"1094_CR22","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/jcmm.13302","volume":"22","author":"SM Davidson","year":"2018","unstructured":"Davidson SM, Riquelme JA, Takov K, Vicencio JM, Boi-Doku C, Khoo V, Doreth C, Radenkovic D, Lavandero S, Yellon DM (2018) Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro. J Cell Mol Med 22:141\u2013151. https:\/\/doi.org\/10.1111\/jcmm.13302","journal-title":"J Cell Mol Med"},{"key":"1094_CR23","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1093\/eurheartj\/ehx414","volume":"38","author":"S de Waha","year":"2017","unstructured":"de Waha S, Patel MR, Granger CB, Ohman EM, Maehara A, Eitel I, Ben-Yehuda O, Jenkins P, Thiele H, Stone GW (2017) Relationship between microvascular obstruction and adverse events following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials. Eur Heart J 38:3502\u20133510. https:\/\/doi.org\/10.1093\/eurheartj\/ehx414","journal-title":"Eur Heart J"},{"key":"1094_CR24","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41581-021-00438-y","volume":"17","author":"MD Donnan","year":"2021","unstructured":"Donnan MD, Kenig-Kozlovsky Y, Quaggin SE (2021) The lymphatics in kidney health and disease. Nat Rev Nephrol 17:655\u2013675. https:\/\/doi.org\/10.1038\/s41581-021-00438-y","journal-title":"Nat Rev Nephrol"},{"key":"1094_CR25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005841","author":"A Durante","year":"2017","unstructured":"Durante A, Laricchia A, Benedetti G, Esposito A, Margonato A, Rimoldi O, De Cobelli F, Colombo A, Camici PG (2017) Identification of high-risk patients after ST-segment-elevation myocardial infarction: comparison between angiographic and magnetic resonance parameters. Circ Cardiovasc Imaging. https:\/\/doi.org\/10.1161\/CIRCIMAGING.116.005841","journal-title":"Circ Cardiovasc Imaging"},{"key":"1094_CR26","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1161\/circresaha.117.310901","volume":"121","author":"R Fern\u00e1ndez-Jim\u00e9nez","year":"2017","unstructured":"Fern\u00e1ndez-Jim\u00e9nez R, Gal\u00e1n-Arriola C, S\u00e1nchez-Gonz\u00e1lez J, Ag\u00fcero J, L\u00f3pez-Mart\u00edn GJ, Gomez-Talavera S, Garcia-Prieto J, Benn A, Molina-Iracheta A, Barreiro-P\u00e9rez M, Martin-Garc\u00eda A, Garc\u00eda-Lunar I, Pizarro G, Sanz J, S\u00e1nchez PL, Fuster V, Ibanez B (2017) Effect of ischemia duration and protective interventions on the temporal dynamics of tissue composition after myocardial infarction. Circ Res 121:439\u2013450. https:\/\/doi.org\/10.1161\/circresaha.117.310901","journal-title":"Circ Res"},{"key":"1094_CR27","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1056\/NEJMoa2107519","volume":"385","author":"JP Fr\u00edas","year":"2021","unstructured":"Fr\u00edas JP, Davies MJ, Rosenstock J, P\u00e9rez Manghi FC, Fern\u00e1ndez Land\u00f3 L, Bergman BK, Liu B, Cui X, Brown K (2021) Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes. N Engl J Med 385:503\u2013515. https:\/\/doi.org\/10.1056\/NEJMoa2107519","journal-title":"N Engl J Med"},{"key":"1094_CR28","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.jacc.2018.11.046","volume":"73","author":"C Gal\u00e1n-Arriola","year":"2019","unstructured":"Gal\u00e1n-Arriola C, Lobo M, V\u00edlchez-Tschischke JP, L\u00f3pez GJ, de Molina-Iracheta A, P\u00e9rez-Mart\u00ednez C, Ag\u00fcero J, Fern\u00e1ndez-Jim\u00e9nez R, Mart\u00edn-Garc\u00eda A, Oliver E, Villena-Gutierrez R, Pizarro G, S\u00e1nchez PL, Fuster V, S\u00e1nchez-Gonz\u00e1lez J, Ibanez B (2019) Serial magnetic resonance imaging to identify early stages of anthracycline-induced cardiotoxicity. J Am Coll Cardiol 73:779\u2013791. https:\/\/doi.org\/10.1016\/j.jacc.2018.11.046","journal-title":"J Am Coll Cardiol"},{"key":"1094_CR29","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/cvr\/cvab053","volume":"118","author":"C Gal\u00e1n-Arriola","year":"2022","unstructured":"Gal\u00e1n-Arriola C, V\u00edlchez-Tschischke JP, Lobo M, L\u00f3pez GJ, de Molina-Iracheta A, P\u00e9rez-Mart\u00ednez C, Villena-Guti\u00e9rrez R, Mac\u00edas \u00c1, D\u00edaz-Rengifo IA, Oliver E, Fuster V, S\u00e1nchez-Gonz\u00e1lez J, Ibanez B (2022) Coronary microcirculation damage in anthracycline cardiotoxicity. Cardiovasc Res 118:531\u2013541. https:\/\/doi.org\/10.1093\/cvr\/cvab053","journal-title":"Cardiovasc Res"},{"key":"1094_CR30","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1093\/cvr\/cvaa181","volume":"117","author":"C Galan-Arriola","year":"2021","unstructured":"Galan-Arriola C, Villena-Gutierrez R, Higuero-Verdejo MI, Diaz-Rengifo IA, Pizarro G, Lopez GJ, Molina-Iracheta A, Perez-Martinez C, Garcia RD, Gonzalez-Calle D, Lobo M, Sanchez PL, Oliver E, Cordoba R, Fuster V, Sanchez-Gonzalez J, Ibanez B (2021) Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity. Cardiovasc Res 117:1132\u20131143. https:\/\/doi.org\/10.1093\/cvr\/cvaa181","journal-title":"Cardiovasc Res"},{"key":"1094_CR31","doi-asserted-by":"publisher","first-page":"14780","DOI":"10.1038\/ncomms14780","volume":"8","author":"J Garcia-Prieto","year":"2017","unstructured":"Garcia-Prieto J, Villena-Gutierrez R, Gomez M, Bernardo E, Pun-Garcia A, Garcia-Lunar I, Crainiciuc G, Fernandez-Jimenez R, Sreeramkumar V, Bourio-Martinez R, Garcia-Ruiz JM, Del Valle AS, Sanz-Rosa D, Pizarro G, Fernandez-Ortiz A, Hidalgo A, Fuster V, Ibanez B (2017) Neutrophil stunning by metoprolol reduces infarct size. Nat Commun 8:14780. https:\/\/doi.org\/10.1038\/ncomms14780","journal-title":"Nat Commun"},{"key":"1094_CR32","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/s0140-6736(19)31149-3","volume":"394","author":"HC Gerstein","year":"2019","unstructured":"Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, Probstfield J, Riesmeyer JS, Riddle MC, Ryd\u00e9n L, Xavier D, Atisso CM, Dyal L, Hall S, Rao-Melacini P, Wong G, Avezum A, Basile J, Chung N, Conget I, Cushman WC, Franek E, Hancu N, Hanefeld M, Holt S, Jansky P, Keltai M, Lanas F, Leiter LA, Lopez-Jaramillo P, Cardona Munoz EG, Pirags V, Pogosova N, Raubenheimer PJ, Shaw JE, Sheu WH, Temelkova-Kurktschiev T (2019) Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial. Lancet 394:121\u2013130. https:\/\/doi.org\/10.1016\/s0140-6736(19)31149-3","journal-title":"Lancet"},{"key":"1094_CR33","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1016\/j.jcmg.2021.02.031","volume":"14","author":"S G\u00f3mez-Talavera","year":"2021","unstructured":"G\u00f3mez-Talavera S, Fernandez-Jimenez R, Fuster V, Nothnagel ND, Kouwenhoven M, Clemence M, Garc\u00eda-Lunar I, G\u00f3mez-Rub\u00edn MC, Navarro F, P\u00e9rez-Asenjo B, Fern\u00e1ndez-Friera L, Calero MJ, Orejas M, Cabrera JA, Desco M, Pizarro G, Ib\u00e1\u00f1ez B, S\u00e1nchez-Gonz\u00e1lez J (2021) Clinical validation of a 3-dimensional ultrafast cardiac magnetic resonance protocol including single breath-hold 3-dimensional sequences. JACC Cardiovasc Imaging 14:1742\u20131754. https:\/\/doi.org\/10.1016\/j.jcmg.2021.02.031","journal-title":"JACC Cardiovasc Imaging"},{"key":"1094_CR34","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41586-023-05972-2","volume":"618","author":"GQ Gong","year":"2023","unstructured":"Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B (2023) A small-molecule PI3Kalpha activator for cardioprotection and neuroregeneration. Nature 618:159\u2013168. https:\/\/doi.org\/10.1038\/s41586-023-05972-2","journal-title":"Nature"},{"key":"1094_CR35","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1152\/physiol.00041.2018","volume":"34","author":"AV Gourine","year":"2019","unstructured":"Gourine AV, Ackland GL (2019) Cardiac vagus and exercise. Physiology (Bethesda) 34:71\u201380. https:\/\/doi.org\/10.1152\/physiol.00041.2018","journal-title":"Physiology (Bethesda)"},{"key":"1094_CR36","doi-asserted-by":"publisher","first-page":"e161","DOI":"10.1093\/cvr\/cvz242","volume":"115","author":"DJ Hausenloy","year":"2019","unstructured":"Hausenloy DJ, B\u00f8tker HE (2019) Why did remote ischaemic conditioning not improve clinical outcomes in acute myocardial infarction in the CONDI-2\/ERIC-PPCI trial? Cardiovasc Res 115:e161\u2013e163. https:\/\/doi.org\/10.1093\/cvr\/cvz242","journal-title":"Cardiovasc Res"},{"key":"1094_CR37","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1093\/cvr\/cvy286","volume":"115","author":"DJ Hausenloy","year":"2019","unstructured":"Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G (2019) The coronary circulation in acute myocardial ischaemia\/reperfusion injury: a target for cardioprotection. Cardiovasc Res 115:1143\u20131155. https:\/\/doi.org\/10.1093\/cvr\/cvy286","journal-title":"Cardiovasc Res"},{"key":"1094_CR38","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/s0140-6736(19)32039-2","volume":"394","author":"DJ Hausenloy","year":"2019","unstructured":"Hausenloy DJ, Kharbanda RK, M\u00f8ller UK, Ramlall M, Aar\u00f8e J, Butler R, Bulluck H, Clayton T, Dana A, Dodd M, Engstrom T, Evans R, Lassen JF, Christensen EF, Garcia-Ruiz JM, Gorog DA, Hjort J, Houghton RF, Ibanez B, Knight R, Lippert FK, L\u00f8nborg JT, Maeng M, Milasinovic D, More R, Nicholas JM, Jensen LO, Perkins A, Radovanovic N, Rakhit RD, Ravkilde J, Ryding AD, Schmidt MR, Riddervold IS, S\u00f8rensen HT, Stankovic G, Varma M, Webb I, Terkelsen CJ, Greenwood JP, Yellon DM, B\u00f8tker HE (2019) Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2\/ERIC-PPCI): a single-blind randomised controlled trial. Lancet 394:1415\u20131424. https:\/\/doi.org\/10.1016\/s0140-6736(19)32039-2","journal-title":"Lancet"},{"key":"1094_CR39","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00395-020-0794-2","volume":"115","author":"DJ Hausenloy","year":"2020","unstructured":"Hausenloy DJ, Ntsekhe M, Yellon DM (2020) A future for remote ischaemic conditioning in high-risk patients. Basic Res Cardiol 115:35. https:\/\/doi.org\/10.1007\/s00395-020-0794-2","journal-title":"Basic Res Cardiol"},{"key":"1094_CR40","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1056\/NEJMoa2204233","volume":"388","author":"WG Herrington","year":"2023","unstructured":"Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, Emberson JR, Preiss D, Judge P, Mayne KJ, Ng SYA, Sammons E, Zhu D, Hill M, Stevens W, Wallendszus K, Brenner S, Cheung AK, Liu ZH, Li J, Hooi LS, Liu W, Kadowaki T, Nangaku M, Levin A, Cherney D, Maggioni AP, Pontremoli R, Deo R, Goto S, Rossello X, Tuttle KR, Steubl D, Petrini M, Massey D, Eilbracht J, Brueckmann M, Landray MJ, Baigent C, Haynes R (2023) Empagliflozin in patients with chronic kidney disease. N Engl J Med 388:117\u2013127. https:\/\/doi.org\/10.1056\/NEJMoa2204233","journal-title":"N Engl J Med"},{"key":"1094_CR41","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1093\/cvr\/cvad111","volume":"119","author":"G Heusch","year":"2023","unstructured":"Heusch G (2023) Cardioprotection in cardio-oncology: a case for concern? Cardiovasc Res 119:e144\u2013e145. https:\/\/doi.org\/10.1093\/cvr\/cvad111","journal-title":"Cardiovasc Res"},{"key":"1094_CR42","doi-asserted-by":"publisher","unstructured":"Heusch G (2016) The Coronary Circulation as a Target of Cardioprotection.1643\u20131658 https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.308640","DOI":"10.1161\/CIRCRESAHA.116.308640"},{"key":"1094_CR43","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00395-019-0756-8","volume":"114","author":"G Heusch","year":"2019","unstructured":"Heusch G (2019) Coronary microvascular obstruction: the new frontier in cardioprotection. Basic Res Cardiol 114:45. https:\/\/doi.org\/10.1007\/s00395-019-0756-8","journal-title":"Basic Res Cardiol"},{"key":"1094_CR44","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.117.310820","volume":"120","author":"G Heusch","year":"2017","unstructured":"Heusch G (2017) Critical issues for the translation of cardioprotection. Circ Res 120:1477\u20131486. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.310820","journal-title":"Circ Res"},{"key":"1094_CR45","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","volume":"17","author":"G Heusch","year":"2020","unstructured":"Heusch G (2020) Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17:773\u2013789. https:\/\/doi.org\/10.1038\/s41569-020-0403-y","journal-title":"Nat Rev Cardiol"},{"key":"1094_CR46","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.medj.2023.12.007","volume":"5","author":"G Heusch","year":"2024","unstructured":"Heusch G (2024) Myocardial ischemia\/reperfusion: Translational pathophysiology of ischemic heart disease. Med 5:10\u201331. https:\/\/doi.org\/10.1016\/j.medj.2023.12.007","journal-title":"Med"},{"key":"1094_CR47","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/j.jcin.2017.05.063","volume":"10","author":"G Heusch","year":"2017","unstructured":"Heusch G (2017) Vagal cardioprotection in reperfused acute myocardial infarction. JACC Cardiovasc Interv 10:1521\u20131522. https:\/\/doi.org\/10.1016\/j.jcin.2017.05.063","journal-title":"JACC Cardiovasc Interv"},{"key":"1094_CR48","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1093\/eurheartj\/ehad160","volume":"44","author":"G Heusch","year":"2023","unstructured":"Heusch G, B\u00f8tker HE, Ferdinandy P, Schulz R (2023) Primordial non-responsiveness: a neglected obstacle to cardioprotection. Eur Heart J 44:1687\u20131689. https:\/\/doi.org\/10.1093\/eurheartj\/ehad160","journal-title":"Eur Heart J"},{"key":"1094_CR49","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jacc.2014.10.031","volume":"65","author":"G Heusch","year":"2015","unstructured":"Heusch G, Botker HE, Przyklenk K, Redington A, Yellon D (2015) Remote ischemic conditioning. J Am Coll Cardiol 65:177\u2013195. https:\/\/doi.org\/10.1016\/j.jacc.2014.10.031","journal-title":"J Am Coll Cardiol"},{"key":"1094_CR50","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1161\/CIRCULATIONAHA.119.044176","volume":"141","author":"G Heusch","year":"2020","unstructured":"Heusch G, Gersh BJ (2020) Is Cardioprotection Salvageable? Circulation 141:415\u2013417. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.044176","journal-title":"Circulation"},{"key":"1094_CR51","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1093\/eurheartj\/ehae079","volume":"45","author":"G Heusch","year":"2024","unstructured":"Heusch G, Kleinbongard P (2024) Cardioprotection research has left its comfort zone. Eur Heart J 45:1568\u20131570. https:\/\/doi.org\/10.1093\/eurheartj\/ehae079","journal-title":"Eur Heart J"},{"key":"1094_CR52","unstructured":"Heusch G, Kleinbongard P (2025) The enigmata of SGLT2 inhibition in cardioprotection. JACC Basic Transl Sci:(in press)"},{"key":"1094_CR53","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jacc.2019.05.024","volume":"74","author":"B Ibanez","year":"2019","unstructured":"Ibanez B, Aletras AH, Arai AE, Arheden H, Bax J, Berry C, Bucciarelli-Ducci C, Croisille P, Dall\u2019Armellina E, Dharmakumar R, Eitel I, Fernandez-Jimenez R, Friedrich MG, Garcia-Dorado D, Hausenloy DJ, Kim RJ, Kozerke S, Kramer CM, Salerno M, Sanchez-Gonzalez J, Sanz J, Fuster V (2019) Cardiac MRI endpoints in myocardial infarction experimental and clinical trials: JACC scientific expert panel. J Am Coll Cardiol 74:238\u2013256. https:\/\/doi.org\/10.1016\/j.jacc.2019.05.024","journal-title":"J Am Coll Cardiol"},{"key":"1094_CR54","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1161\/CIRCULATIONAHA.113.003653","volume":"128","author":"B Ibanez","year":"2013","unstructured":"Ibanez B, Macaya C, Sanchez-Brunete V, Pizarro G, Fernandez-Friera L, Mateos A, Fernandez-Ortiz A, Garcia-Ruiz JM, Garcia-Alvarez A, Iniguez A, Jimenez-Borreguero J, Lopez-Romero P, Fernandez-Jimenez R, Goicolea J, Ruiz-Mateos B, Bastante T, Arias M, Iglesias-Vazquez JA, Rodriguez MD, Escalera N, Acebal C, Cabrera JA, Valenciano J, Perez de Prado A, Fernandez-Campos MJ, Casado I, Garcia-Rubira JC, Garcia-Prieto J, Sanz-Rosa D, Cuellas C, Hernandez-Antolin R, Albarran A, Fernandez-Vazquez F, de la Torre-Hernandez JM, Pocock S, Sanz G, Fuster V (2013) Effect of early metoprolol on infarct size in ST-segment-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: the Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) trial. Circulation 128:1495\u20131503. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.003653","journal-title":"Circulation"},{"key":"1094_CR55","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00395-012-0285-1","volume":"107","author":"RV Jensen","year":"2012","unstructured":"Jensen RV, Stottrup NB, Kristiansen SB, Botker HE (2012) Release of a humoral circulating cardioprotective factor by remote ischemic preconditioning is dependent on preserved neural pathways in diabetic patients. Basic Res Cardiol 107:285. https:\/\/doi.org\/10.1007\/s00395-012-0285-1","journal-title":"Basic Res Cardiol"},{"key":"1094_CR56","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.amjcard.2016.07.056","volume":"118","author":"A Joost","year":"2016","unstructured":"Joost A, Stiermaier T, Eitel C, Fuernau G, de Waha S, Desch S, Thiele H, Eitel I (2016) Impact of initial culprit vessel flow on infarct size, microvascular obstruction, and myocardial salvage in acute reperfused ST-elevation myocardial infarction. Am J Cardiol 118:1316\u20131322. https:\/\/doi.org\/10.1016\/j.amjcard.2016.07.056","journal-title":"Am J Cardiol"},{"key":"1094_CR57","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jacbts.2022.06.008","volume":"8","author":"S Kaul","year":"2023","unstructured":"Kaul S, Methner C, Cao Z, Mishra A (2023) Mechanisms of the \u201cNo-Reflow\u201d phenomenon after acute myocardial infarction: potential role of pericytes. JACC Basic Transl Sci 8:204\u2013220. https:\/\/doi.org\/10.1016\/j.jacbts.2022.06.008","journal-title":"JACC Basic Transl Sci"},{"key":"1094_CR58","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00395-021-00876-6","volume":"116","author":"P Kleinbongard","year":"2021","unstructured":"Kleinbongard P, Andreadou I, Vilahur G (2021) The platelet paradox of injury versus protection in myocardial infarction-has it been overlooked? Basic Res Cardiol 116:37. https:\/\/doi.org\/10.1007\/s00395-021-00876-6","journal-title":"Basic Res Cardiol"},{"key":"1094_CR59","doi-asserted-by":"publisher","first-page":"5252","DOI":"10.1111\/bph.14839","volume":"177","author":"P Kleinbongard","year":"2020","unstructured":"Kleinbongard P, Botker HE, Ovize M, Hausenloy DJ, Heusch G (2020) Co-morbidities and co-medications as confounders of cardioprotection-Does it matter in the clinical setting? Br J Pharmacol 177:5252\u20135269. https:\/\/doi.org\/10.1111\/bph.14839","journal-title":"Br J Pharmacol"},{"key":"1094_CR60","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41569-021-00632-2","volume":"19","author":"P Kleinbongard","year":"2022","unstructured":"Kleinbongard P, Heusch G (2022) A fresh look at coronary microembolization. Nat Rev Cardiol 19:265\u2013280. https:\/\/doi.org\/10.1038\/s41569-021-00632-2","journal-title":"Nat Rev Cardiol"},{"key":"1094_CR61","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1172\/JCI107898","volume":"54","author":"RA Kloner","year":"1974","unstructured":"Kloner RA, Ganote CE, Jennings RB (1974) The \u201cno-reflow\u201d phenomenon after temporary coronary occlusion in the dog. J Clin Invest 54:1496\u20131508. https:\/\/doi.org\/10.1172\/JCI107898","journal-title":"J Clin Invest"},{"key":"1094_CR62","doi-asserted-by":"publisher","first-page":"H550","DOI":"10.1152\/ajpheart.00183.2018","volume":"315","author":"RA Kloner","year":"2018","unstructured":"Kloner RA, King KS, Harrington MG (2018) No-reflow phenomenon in the heart and brain. Am J Physiol Heart Circ Physiol 315:H550\u2013H562. https:\/\/doi.org\/10.1152\/ajpheart.00183.2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1094_CR63","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1093\/cvr\/cvad115","volume":"119","author":"A Korsak","year":"2023","unstructured":"Korsak A, Kellett DO, Aziz Q, Anderson C, D\u2019Souza A, Tinker A, Ackland GL, Gourine AV (2023) Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training. Cardiovasc Res 119:2329\u20132341. https:\/\/doi.org\/10.1093\/cvr\/cvad115","journal-title":"Cardiovasc Res"},{"key":"1094_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cjca.2023.09.020","volume":"40","author":"A Kumar","year":"2024","unstructured":"Kumar A, Connelly K, Vora K, Bainey KR, Howarth A, Leipsic J, Betteridge-LeBlanc S, Prato FS, Leong-Poi H, Main A, Atoui R, Saw J, Larose E, Graham MM, Ruel M, Dharmakumar R (2024) The Canadian cardiovascular society classification of acute atherothrombotic myocardial infarction based on stages of tissue injury severity: an expert consensus statement. Can J Cardiol 40:1\u201314. https:\/\/doi.org\/10.1016\/j.cjca.2023.09.020","journal-title":"Can J Cardiol"},{"key":"1094_CR65","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.yjmcc.2009.03.019","volume":"47","author":"S Lecour","year":"2009","unstructured":"Lecour S (2009) Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway? J Mol Cell Cardiol 47:32\u201340. https:\/\/doi.org\/10.1016\/j.yjmcc.2009.03.019","journal-title":"J Mol Cell Cardiol"},{"key":"1094_CR66","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1161\/CIRCRESAHA.115.303633","volume":"118","author":"CG Lenneman","year":"2016","unstructured":"Lenneman CG, Sawyer DB (2016) Cardio-oncology: an update on cardiotoxicity of cancer-related treatment. Circ Res 118:1008\u20131020. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.303633","journal-title":"Circ Res"},{"key":"1094_CR67","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1007\/s11255-024-04005-9","volume":"56","author":"K Li","year":"2024","unstructured":"Li K, Hou Q, Li X, Tian L, Wang L, Wu S, Han Q (2024) Triglyceride-glucose index predicts major adverse cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol 56:2793\u20132802. https:\/\/doi.org\/10.1007\/s11255-024-04005-9","journal-title":"Int Urol Nephrol"},{"key":"1094_CR68","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1161\/CIRCRESAHA.118.313859","volume":"123","author":"HR Lieder","year":"2018","unstructured":"Lieder HR, Kleinbongard P, Skyschally A, Hagelschuer H, Chilian WM, Heusch G (2018) Vago-splenic axis in signal transduction of remote ischemic preconditioning in pigs and rats. Circ Res 123:1152\u20131163. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313859","journal-title":"Circ Res"},{"key":"1094_CR69","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1093\/eurheartj\/ehae250","volume":"45","author":"HR Lieder","year":"2024","unstructured":"Lieder HR, Paket U, Skyschally A, Rink AD, Baars T, Neuhauser M, Kleinbongard P, Heusch G (2024) Vago-splenic signal transduction of cardioprotection in humans. Eur Heart J 45:3164\u20133177. https:\/\/doi.org\/10.1093\/eurheartj\/ehae250","journal-title":"Eur Heart J"},{"key":"1094_CR70","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00395-010-0099-y","volume":"105","author":"SY Lim","year":"2010","unstructured":"Lim SY, Yellon DM, Hausenloy DJ (2010) The neural and humoral pathways in remote limb ischemic preconditioning. Basic Res Cardiol 105:651\u2013655. https:\/\/doi.org\/10.1007\/s00395-010-0099-y","journal-title":"Basic Res Cardiol"},{"key":"1094_CR71","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10557-021-07283-y","volume":"37","author":"K Lukhna","year":"2023","unstructured":"Lukhna K, Hausenloy DJ, Ali AS, Bajaber A, Calver A, Mutyaba A, Mohamed AA, Kiggundu B, Chishala C, Variava E, Elmakki EA, Ogola E, Hamid E, Okello E, Gaafar I, Mwazo K, Makotoko M, Naidoo M, Abdelhameed ME, Badri M, van der Schyff N, Abozaid O, Xafis P, Giesz S, Gould T, Welgemoed W, Walker M, Ntsekhe M, Yellon DM (2023) Remote ischaemic conditioning in STEMI patients in sub-Saharan AFRICA: rationale and study design for the RIC-AFRICA trial. Cardiovasc Drugs Ther 37:299\u2013305. https:\/\/doi.org\/10.1007\/s10557-021-07283-y","journal-title":"Cardiovasc Drugs Ther"},{"key":"1094_CR72","doi-asserted-by":"crossref","unstructured":"Lukhna K HH, Popat B, Crombie K, Vallie W, Petersen I, Tulleken M, Edwards BL, Van Der Schyff N , Gould T, Hitzerhoth J, Ntsekhe M (2024) 1-year outcomes of patients presenting with acute coronary syndromes in Western Cape, South Africa: findings from the PERFUSION ACS registry. In: 2024 EC (ed) ESC Congress 2024 London","DOI":"10.1093\/eurheartj\/ehae666.1565"},{"key":"1094_CR73","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.jaccao.2023.03.008","volume":"5","author":"M Mallouppas","year":"2023","unstructured":"Mallouppas M, Chung R, Ghosh AK, Macklin A, Yellon DM, Walker JM (2023) Anthracyclines and biomarkers of myocardial injury: the effect of remote ischemic conditioning. JACC CardioOncol 5:343\u2013355. https:\/\/doi.org\/10.1016\/j.jaccao.2023.03.008","journal-title":"JACC CardioOncol"},{"key":"1094_CR74","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.jcmg.2020.01.017","volume":"13","author":"A Martin-Garcia","year":"2020","unstructured":"Martin-Garcia A, Diaz-Pelaez E, Lopez-Corral L, Sanchez-Pablo C, Macias de Plasencia G, Galan-Arriola C, Sanchez-Gonzalez J, Cruz JJ, Ibanez B, Sanchez PL (2020) T2 mapping identifies early anthracycline-induced cardiotoxicity in elderly patients with cancer. JACC Cardiovasc Imaging 13:1630\u20131632. https:\/\/doi.org\/10.1016\/j.jcmg.2020.01.017","journal-title":"JACC Cardiovasc Imaging"},{"key":"1094_CR75","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1161\/hc1002.105938","volume":"105","author":"A Masumoto","year":"2002","unstructured":"Masumoto A, Mohri M, Shimokawa H, Urakami L, Usui M, Takeshita A (2002) Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation 105:1545\u20131547. https:\/\/doi.org\/10.1161\/hc1002.105938","journal-title":"Circulation"},{"key":"1094_CR76","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-024-01078-6","author":"A Moreno-Arciniegas","year":"2024","unstructured":"Moreno-Arciniegas A, Cadiz L, Galan-Arriola C, Clemente-Moragon A, Ibanez B (2024) Cardioprotection strategies for anthracycline cardiotoxicity. Basic Res Cardiol. https:\/\/doi.org\/10.1007\/s00395-024-01078-6","journal-title":"Basic Res Cardiol"},{"key":"1094_CR77","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1002\/ejhf.3395","volume":"26","author":"A Moreno-Arciniegas","year":"2024","unstructured":"Moreno-Arciniegas A, Garcia A, Kelm M, D\u2019Amore F, da Silva MG, Sanchez-Gonzalez J, Sanchez PL, Lopez-Fernandez T, Cordoba R, Asteggiano R, Camus V, Smink J, Ferreira A, Kersten MJ, Bolanos N, Escalera N, Pacella E, Gomez-Talavera S, Quesada A, Rossello X, Ibanez B, Investigators RT (2024) Rationale and design of RESILIENCE: a prospective randomized clinical trial evaluating remote ischaemic conditioning for the prevention of anthracycline cardiotoxicity. Eur J Heart Fail 26:2213\u20132222. https:\/\/doi.org\/10.1002\/ejhf.3395","journal-title":"Eur J Heart Fail"},{"key":"1094_CR78","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1093\/eurheartj\/ehw136","volume":"37","author":"SA Nazir","year":"2016","unstructured":"Nazir SA, McCann GP, Greenwood JP, Kunadian V, Khan JN, Mahmoud IZ, Blackman DJ, Been M, Abrams KR, Shipley L, Wilcox R, Adgey AA, Gershlick AH (2016) Strategies to attenuate micro-vascular obstruction during P-PCI: the randomized reperfusion facilitated by local adjunctive therapy in ST-elevation myocardial infarction trial. Eur Heart J 37:1910\u20131919. https:\/\/doi.org\/10.1093\/eurheartj\/ehw136","journal-title":"Eur Heart J"},{"key":"1094_CR79","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1161\/CIR.0000000000001184","volume":"148","author":"CE Ndumele","year":"2023","unstructured":"Ndumele CE, Rangaswami J, Chow SL, Neeland IJ, Tuttle KR, Khan SS, Coresh J, Mathew RO, Baker-Smith CM, Carnethon MR, Despres JP, Ho JE, Joseph JJ, Kernan WN, Khera A, Kosiborod MN, Lekavich CL, Lewis EF, Lo KB, Ozkan B, Palaniappan LP, Patel SS, Pencina MJ, Powell-Wiley TM, Sperling LS, Virani SS, Wright JT, Rajgopal Singh R, Elkind MSV, American Heart A (2023) Cardiovascular-kidney-metabolic health: a presidential advisory from the American heart association. Circulation 148:1606\u20131635. https:\/\/doi.org\/10.1161\/CIR.0000000000001184","journal-title":"Circulation"},{"key":"1094_CR80","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1161\/CIRCRESAHA.119.315344","volume":"125","author":"G Niccoli","year":"2019","unstructured":"Niccoli G, Montone RA, Ibanez B, Thiele H, Crea F, Heusch G, Bulluck H, Hausenloy DJ, Berry C, Stiermaier T, Camici PG, Eitel I (2019) Optimized treatment of ST-elevation myocardial infarction. Circ Res 125:245\u2013258. https:\/\/doi.org\/10.1161\/CIRCRESAHA.119.315344","journal-title":"Circ Res"},{"key":"1094_CR81","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1056\/NEJMoa2022190","volume":"383","author":"M Packer","year":"2020","unstructured":"Packer M, Anker SD, Butler J, Filippatos G, Pocock SJ, Carson P, Januzzi J, Verma S, Tsutsui H, Brueckmann M, Jamal W, Kimura K, Schnee J, Zeller C, Cotton D, Bocchi E, Bohm M, Choi DJ, Chopra V, Chuquiure E, Giannetti N, Janssens S, Zhang J, Gonzalez Juanatey JR, Kaul S, Brunner-La Rocca HP, Merkely B, Nicholls SJ, Perrone S, Pina I, Ponikowski P, Sattar N, Senni M, Seronde MF, Spinar J, Squire I, Taddei S, Wanner C, Zannad F, Investigators EM-RT (2020) Cardiovascular and renal outcomes with empagliflozin in heart failure. N Engl J Med 383:1413\u20131424. https:\/\/doi.org\/10.1056\/NEJMoa2022190","journal-title":"N Engl J Med"},{"key":"1094_CR82","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10557-022-07397-x","volume":"37","author":"L Pearce","year":"2023","unstructured":"Pearce L, Carr RD, Yellon DM, Davidson SM (2023) Nicorandil: an effective multitarget drug for cardioprotection? Cardiovasc Drugs Ther 37:5\u20138. https:\/\/doi.org\/10.1007\/s10557-022-07397-x","journal-title":"Cardiovasc Drugs Ther"},{"key":"1094_CR83","doi-asserted-by":"publisher","first-page":"A11926","DOI":"10.1161\/circ.146.suppl_1.11926","volume":"146","author":"L Pearce","year":"2022","unstructured":"Pearce L, He D, Davidson SM, Yellon DM (2022) Abstract 11926: selective inhibition of rho kinase 2 limits no re-flow in rat hearts following ischemia\/reperfusion. Circulation 146:A11926\u2013A11926. https:\/\/doi.org\/10.1161\/circ.146.suppl_1.11926","journal-title":"Circulation"},{"key":"1094_CR84","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1056\/NEJMoa2403347","volume":"391","author":"V Perkovic","year":"2024","unstructured":"Perkovic V, Tuttle KR, Rossing P, Mahaffey KW, Mann JFE, Bakris G, Baeres FMM, Idorn T, Bosch-Traberg H, Lausvig NL, Pratley R, Committees FT, Investigators (2024) Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes. N Engl J Med 391:109\u2013121. https:\/\/doi.org\/10.1056\/NEJMoa2403347","journal-title":"N Engl J Med"},{"key":"1094_CR85","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00395-014-0453-6","volume":"110","author":"JM Pickard","year":"2015","unstructured":"Pickard JM, Botker HE, Crimi G, Davidson B, Davidson SM, Dutka D, Ferdinandy P, Ganske R, Garcia-Dorado D, Giricz Z, Gourine AV, Heusch G, Kharbanda R, Kleinbongard P, MacAllister R, McIntyre C, Meybohm P, Prunier F, Redington A, Robertson NJ, Suleiman MS, Vanezis A, Walsh S, Yellon DM, Hausenloy DJ (2015) Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop. Basic Res Cardiol 110:453. https:\/\/doi.org\/10.1007\/s00395-014-0453-6","journal-title":"Basic Res Cardiol"},{"key":"1094_CR86","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s00395-016-0568-z","volume":"111","author":"JM Pickard","year":"2016","unstructured":"Pickard JM, Davidson SM, Hausenloy DJ, Yellon DM (2016) Co-dependence of the neural and humoral pathways in the mechanism of remote ischemic conditioning. Basic Res Cardiol 111:50. https:\/\/doi.org\/10.1007\/s00395-016-0568-z","journal-title":"Basic Res Cardiol"},{"key":"1094_CR87","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1152\/physiol.00030.2013","volume":"29","author":"SK Powers","year":"2014","unstructured":"Powers SK, Smuder AJ, Kavazis AN, Quindry JC (2014) Mechanisms of exercise-induced cardioprotection. Physiology (Bethesda) 29:27\u201338. https:\/\/doi.org\/10.1152\/physiol.00030.2013","journal-title":"Physiology (Bethesda)"},{"key":"1094_CR88","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026232","author":"G Qian","year":"2022","unstructured":"Qian G, Zhang Y, Dong W, Jiang ZC, Li T, Cheng LQ, Zou YT, Jiang XS, Zhou HAX, Li P, Chen ML, Su X, Tian JW, Shi B, Li ZZ, Wu YQ, Li YJ, Chen YD (2022) Effects of nicorandil administration on infarct size in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention: the CHANGE trial. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.122.026232","journal-title":"J Am Heart Assoc"},{"key":"1094_CR89","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae496","author":"B Rivero-Santana","year":"2024","unstructured":"Rivero-Santana B, Saldana-Garcia J, Caro-Codon J, Zamora P, Moliner P, Martinez Monzonis A, Zatarain E, Alvarez-Ortega C, Gomez-Prieto P, Pernas S, Rodriguez I, Buno Soto A, Cadenas R, Palacios Ozores P, Perez Ramirez S, Merino Salvador M, Valbuena S, Fernandez Gasso L, Juarez V, Severo A, Terol B, de Soto AT, Rodriguez O, Brion M, Gonzalez-Costello J, Canales Albendea M, Gonzalez-Juanatey JR, Moreno R, Lopez-Sendon J, Lopez-Fernandez T (2024) Anthracycline-induced cardiovascular toxicity: validation of the Heart Failure Association and International Cardio-Oncology Society risk score. Eur Heart J. https:\/\/doi.org\/10.1093\/eurheartj\/ehae496","journal-title":"Eur Heart J"},{"key":"1094_CR90","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s00395-017-0657-7","volume":"112","author":"X Rossello","year":"2017","unstructured":"Rossello X, Riquelme JA, He Z, Taferner S, Vanhaesebroeck B, Davidson SM, Yellon DM (2017) The role of PI3Kalpha isoform in cardioprotection. Basic Res Cardiol 112:66. https:\/\/doi.org\/10.1007\/s00395-017-0657-7","journal-title":"Basic Res Cardiol"},{"key":"1094_CR91","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s00395-017-0662-x","volume":"113","author":"X Rossello","year":"2018","unstructured":"Rossello X, Yellon DM (2018) The RISK pathway and beyond. Basic Res Cardiol 113:2. https:\/\/doi.org\/10.1007\/s00395-017-0662-x","journal-title":"Basic Res Cardiol"},{"key":"1094_CR92","doi-asserted-by":"publisher","first-page":"C1174","DOI":"10.1152\/ajpcell.00450.2011","volume":"302","author":"I Sabolic","year":"2012","unstructured":"Sabolic I, Vrhovac I, Eror DB, Gerasimova M, Rose M, Breljak D, Ljubojevic M, Brzica H, Sebastiani A, Thal SC, Sauvant C, Kipp H, Vallon V, Koepsell H (2012) Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences. Am J Physiol Cell Physiol 302:C1174-1188. https:\/\/doi.org\/10.1152\/ajpcell.00450.2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"1094_CR93","doi-asserted-by":"publisher","first-page":"758","DOI":"10.2174\/1570161112666140613115813","volume":"12","author":"S Satoh","year":"2014","unstructured":"Satoh S, Ikegaki I, Kawasaki K, Asano T, Shibuya M (2014) Pleiotropic effects of the rho-kinase inhibitor fasudil after subarachnoid hemorrhage: a review of preclinical and clinical studies. Curr Vasc Pharmacol 12:758\u2013765. https:\/\/doi.org\/10.2174\/1570161112666140613115813","journal-title":"Curr Vasc Pharmacol"},{"key":"1094_CR94","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1111\/j.1582-4934.2009.00796.x","volume":"14","author":"V Sivaraman","year":"2010","unstructured":"Sivaraman V, Hausenloy DJ, Wynne AM, Yellon DM (2010) Preconditioning the diabetic human myocardium. J Cell Mol Med 14:1740\u20131746. https:\/\/doi.org\/10.1111\/j.1582-4934.2009.00796.x","journal-title":"J Cell Mol Med"},{"key":"1094_CR95","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ijcard.2019.01.038","volume":"280","author":"M Totzeck","year":"2019","unstructured":"Totzeck M, Schuler M, Stuschke M, Heusch G, Rassaf T (2019) Cardio-oncology - strategies for management of cancer-therapy related cardiovascular disease. Int J Cardiol 280:163\u2013175. https:\/\/doi.org\/10.1016\/j.ijcard.2019.01.038","journal-title":"Int J Cardiol"},{"key":"1094_CR96","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s00395-023-00992-5","volume":"118","author":"DM Yellon","year":"2023","unstructured":"Yellon DM, Beikoghli Kalkhoran S, Davidson SM (2023) The RISK pathway leading to mitochondria and cardioprotection: how everything started. Basic Res Cardiol 118:22. https:\/\/doi.org\/10.1007\/s00395-023-00992-5","journal-title":"Basic Res Cardiol"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-024-01094-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-024-01094-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-024-01094-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T07:02:09Z","timestamp":1744009329000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-024-01094-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":96,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["1094"],"URL":"https:\/\/doi.org\/10.1007\/s00395-024-01094-6","relation":{},"ISSN":["1435-1803"],"issn-type":[{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"assertion":[{"value":"4 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}