{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:18:32Z","timestamp":1792783112421,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860230"],"award-info":[{"award-number":["81860230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62027812"],"award-info":[{"award-number":["62027812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013078","name":"Natural Science Research Project of Guizhou Province","doi-asserted-by":"publisher","award":["ZK [2024]-257"],"award-info":[{"award-number":["ZK [2024]-257"]}],"id":[{"id":"10.13039\/501100013078","id-type":"DOI","asserted-by":"publisher"}]},{"name":"STI2030-Major Projects","award":["2021ZD0202900"],"award-info":[{"award-number":["2021ZD0202900"]}]},{"name":"Innovation Team Project of Zhuhai Campus of Zunyi Medical University","award":["ZHTD2024-1"],"award-info":[{"award-number":["ZHTD2024-1"]}],"id":[{"id":"https:\/\/ror.org\/00g5b0g93","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Doctoral Start-up Foundation of zunyi medical university","award":["F-878"],"award-info":[{"award-number":["F-878"]}],"id":[{"id":"https:\/\/ror.org\/00g5b0g93","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"DOI":"10.1007\/s00395-025-01096-y","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T08:45:27Z","timestamp":1742719527000},"page":"423-441","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exendin-4 improves cerebral ischemia by relaxing microvessels, rapidly increasing cerebral blood flow after reperfusion"],"prefix":"10.1007","volume":"120","author":[{"given":"Yujie","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huisen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-3119","authenticated-orcid":false,"given":"Chen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"key":"1096_CR1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ejphar.2018.05.045","volume":"833","author":"RG Abdel-Latif","year":"2018","unstructured":"Abdel-Latif RG, Heeba GH, Taye A, Khalifa MMA (2018) Lixisenatide ameliorates cerebral ischemia-reperfusion injury via GLP-1 receptor dependent\/independent pathways. Eur J Pharmacol 833:145\u2013154. https:\/\/doi.org\/10.1016\/j.ejphar.2018.05.045","journal-title":"Eur J Pharmacol"},{"key":"1096_CR2","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00210-018-1497-1","volume":"391","author":"RG Abdel-Latif","year":"2018","unstructured":"Abdel-Latif RG, Heeba GH, Taye A, Khalifa MMA (2018) Lixisenatide, a novel GLP-1 analog, protects against cerebral ischemia\/reperfusion injury in diabetic rats. N-S Arch Pharmacol 391:705\u2013717. https:\/\/doi.org\/10.1007\/s00210-018-1497-1","journal-title":"N-S Arch Pharmacol"},{"key":"1096_CR3","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/bph.15524","volume":"179","author":"IL Augestad","year":"2022","unstructured":"Augestad IL, Dekens D, Karampatsi D, Elabi O, Zabala A, Pintana H, Larsson M, Nystrom T, Paul G, Darsalia V, Patrone C (2022) Normalisation of glucose metabolism by exendin-4 in the chronic phase after stroke promotes functional recovery in male diabetic mice. Br J Pharmacol 179:677\u2013694. https:\/\/doi.org\/10.1111\/bph.15524","journal-title":"Br J Pharmacol"},{"key":"1096_CR4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/s41582-018-0002-2","volume":"14","author":"JC Baron","year":"2018","unstructured":"Baron JC (2018) Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke. Nat Rev Neurol 14:325\u2013337. https:\/\/doi.org\/10.1038\/s41582-018-0002-2","journal-title":"Nat Rev Neurol"},{"key":"1096_CR5","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/cvr\/cvw216","volume":"112","author":"MV Basalay","year":"2016","unstructured":"Basalay MV, Mastitskaya S, Mrochek A, Ackland GL, Del Arroyo AG, Sanchez J, Sjoquist PO, Pernow J, Gourine AV, Gourine A (2016) Glucagon-like peptide-1 (GLP-1) mediates cardioprotection by remote ischaemic conditioning. Cardiovasc Res 112:669\u2013676. https:\/\/doi.org\/10.1093\/cvr\/cvw216","journal-title":"Cardiovasc Res"},{"key":"1096_CR6","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1161\/STROKEAHA.119.027557","volume":"51","author":"G Bellastella","year":"2020","unstructured":"Bellastella G, Maiorino MI, Longo M, Scappaticcio L, Chiodini P, Esposito K, Giugliano D (2020) Glucagon-like peptide-1 receptor agonists and prevention of stroke systematic review of cardiovascular outcome trials with meta-analysis. Stroke 51:666\u2013669. https:\/\/doi.org\/10.1161\/STROKEAHA.119.027557","journal-title":"Stroke"},{"key":"1096_CR7","doi-asserted-by":"publisher","DOI":"10.3791\/53208","author":"AC Boulay","year":"2015","unstructured":"Boulay AC, Saubamea B, Decleves X, Cohen-Salmon M (2015) Purification of mouse brain vessels. J Vis Exp. https:\/\/doi.org\/10.3791\/53208","journal-title":"J Vis Exp"},{"key":"1096_CR8","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1056\/NEJMc1615712","volume":"376","author":"F Cosmi","year":"2017","unstructured":"Cosmi F, Laini R, Nicolucci A (2017) Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 376:890. https:\/\/doi.org\/10.1056\/NEJMc1615712","journal-title":"N Engl J Med"},{"key":"1096_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae147","author":"T Dalkara","year":"2024","unstructured":"Dalkara T, Ostergaard L, Heusch G, Attwell D (2024) Pericytes in the brain and heart: functional roles and response to ischemia and reperfusion. Cardiovasc Res. https:\/\/doi.org\/10.1093\/cvr\/cvae147","journal-title":"Cardiovasc Res"},{"key":"1096_CR10","doi-asserted-by":"publisher","first-page":"zqac007","DOI":"10.1093\/function\/zqac007","volume":"3","author":"MJ Davis","year":"2022","unstructured":"Davis MJ (2022) TRPM4 Inhibition: An Unexpected Mechanism of NO-Induced Vasodilatation. Function 3:zqac007. https:\/\/doi.org\/10.1093\/function\/zqac007","journal-title":"Function"},{"key":"1096_CR11","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1007\/s00125-023-05906-7","volume":"66","author":"DJ Drucker","year":"2023","unstructured":"Drucker DJ, Holst JJ (2023) The expanding incretin universe: from basic biology to clinical translation. Diabetologia 66:1765\u20131779. https:\/\/doi.org\/10.1007\/s00125-023-05906-7","journal-title":"Diabetologia"},{"key":"1096_CR12","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1016\/S0140-6736(06)69705-5","volume":"368","author":"DJ Drucker","year":"2006","unstructured":"Drucker DJ, Nauck MA (2006) The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368:1696\u20131705. https:\/\/doi.org\/10.1016\/S0140-6736(06)69705-5","journal-title":"Lancet"},{"key":"1096_CR13","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jacbts.2016.03.011","volume":"1","author":"JP Giblett","year":"2016","unstructured":"Giblett JP, Clarke SJ, Dutka DP, Hoole SP (2016) Glucagon-like peptide-1: a promising agent for cardioprotection during myocardial ischemia. JACC Basic Transl Sci 1:267\u2013276. https:\/\/doi.org\/10.1016\/j.jacbts.2016.03.011","journal-title":"JACC Basic Transl Sci"},{"key":"1096_CR14","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s12933-021-01366-8","volume":"20","author":"D Giugliano","year":"2021","unstructured":"Giugliano D, Scappaticcio L, Longo M, Caruso P, Maiorino MI, Bellastella G, Ceriello A, Chiodini P, Esposito K (2021) GLP-1 receptor agonists and cardiorenal outcomes in type 2 diabetes: an updated meta-analysis of eight CVOTs. Cardiovasc Diabetol 20:189. https:\/\/doi.org\/10.1186\/s12933-021-01366-8","journal-title":"Cardiovasc Diabetol"},{"key":"1096_CR15","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature13165","volume":"508","author":"CN Hall","year":"2014","unstructured":"Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O\u2019Farrell FM, Buchan AM, Lauritzen M, Attwell D (2014) Capillary pericytes regulate cerebral blood flow in health and disease. Nature 508:55\u201360. https:\/\/doi.org\/10.1038\/nature13165","journal-title":"Nature"},{"key":"1096_CR16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/00004647-200404000-00003","volume":"24","author":"EF Hauck","year":"2004","unstructured":"Hauck EF, Apostel S, Hoffmann JF, Heimann A, Kempski O (2004) Capillary flow and diameter changes during reperfusion after global cerebral ischemia studied by intravital video microscopy. J Cereb Blood Flow Metab 24:383\u2013391. https:\/\/doi.org\/10.1097\/00004647-200404000-00003","journal-title":"J Cereb Blood Flow Metab"},{"key":"1096_CR17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1471-2202-13-33","volume":"13","author":"K Hunter","year":"2012","unstructured":"Hunter K, Holscher C (2012) Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci 13:33. https:\/\/doi.org\/10.1186\/1471-2202-13-33","journal-title":"BMC Neurosci"},{"key":"1096_CR18","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1212\/WNL.0b013e3181b9c847","volume":"73","author":"P Khatri","year":"2009","unstructured":"Khatri P, Abruzzo T, Yeatts SD, Nichols C, Broderick JP, Tomsick TA, Ims I, Investigators II (2009) Good clinical outcome after ischemic stroke with successful revascularization is time-dependent. Neurology 73:1066\u20131072. https:\/\/doi.org\/10.1212\/WNL.0b013e3181b9c847","journal-title":"Neurology"},{"key":"1096_CR19","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1161\/STROKEAHA.116.012934","volume":"47","author":"T Kuroki","year":"2016","unstructured":"Kuroki T, Tanaka R, Shimada Y, Yamashiro K, Ueno Y, Shimura H, Urabe T, Hattori N (2016) Exendin-4 inhibits matrix metalloproteinase-9 activation and reduces infarct growth after focal cerebral ischemia in hyperglycemic mice. Stroke 47:1328\u20131335. https:\/\/doi.org\/10.1161\/STROKEAHA.116.012934","journal-title":"Stroke"},{"key":"1096_CR20","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12974-020-01761-0","volume":"17","author":"X Long","year":"2020","unstructured":"Long X, Yao X, Jiang Q, Yang Y, He X, Tian W, Zhao K, Zhang H (2020) Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury. J Neuroinflammation 17:89. https:\/\/doi.org\/10.1186\/s12974-020-01761-0","journal-title":"J Neuroinflammation"},{"key":"1096_CR21","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nprot.2014.019","volume":"9","author":"A Mishra","year":"2014","unstructured":"Mishra A, O\u2019Farrell FM, Reynell C, Hamilton NB, Hall CN, Attwell D (2014) Imaging pericytes and capillary diameter in brain slices and isolated retinae. Nat Protoc 9:323\u2013336. https:\/\/doi.org\/10.1038\/nprot.2014.019","journal-title":"Nat Protoc"},{"key":"1096_CR22","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","volume":"30","author":"TD Muller","year":"2019","unstructured":"Muller TD, Finan B, Bloom SR, D\u2019Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschop MH (2019) Glucagon-like peptide 1 (GLP-1). Mol Metab 30:72\u2013130. https:\/\/doi.org\/10.1016\/j.molmet.2019.09.010","journal-title":"Mol Metab"},{"key":"1096_CR23","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1161\/CIRCULATIONAHA.117.028136","volume":"136","author":"MA Nauck","year":"2017","unstructured":"Nauck MA, Meier JJ, Cavender MA, Abd El Aziz M, Drucker DJ (2017) Cardiovascular actions and clinical outcomes with glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Circulation 136:849\u2013870. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.028136","journal-title":"Circulation"},{"key":"1096_CR24","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00395-021-00873-9","volume":"116","author":"S Nizari","year":"2021","unstructured":"Nizari S, Basalay M, Chapman P, Korte N, Korsak A, Christie IN, Theparambil SM, Davidson SM, Reimann F, Trapp S, Yellon DM, Gourine AV (2021) Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke. Basic Res Cardiol 116:32. https:\/\/doi.org\/10.1007\/s00395-021-00873-9","journal-title":"Basic Res Cardiol"},{"key":"1096_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-024-01094-6","author":"L Pearce","year":"2024","unstructured":"Pearce L, Galan-Arriola C, Bell RM, Carr RD, Cunningham J, Davidson SM, Ghosh AK, Giesz S, Golforoush P, Gourine AV, Hermann DM, Heusch G, Ibanez B, Kalkhoran SB, Lecour S, Lukhna K, Ntsekhe M, Sack MN, Unwin RJ, Vilahur G, Walker JM, Yellon DM (2024) Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop. Basic Res Cardiol. https:\/\/doi.org\/10.1007\/s00395-024-01094-6","journal-title":"Basic Res Cardiol"},{"key":"1096_CR26","doi-asserted-by":"publisher","DOI":"10.3791\/4038","author":"E Rousselet","year":"2012","unstructured":"Rousselet E, Kriz J, Seidah NG (2012) Mouse model of intraluminal MCAO: cerebral infarct evaluation by cresyl violet staining. J Vis Exp. https:\/\/doi.org\/10.3791\/4038","journal-title":"J Vis Exp"},{"key":"1096_CR27","doi-asserted-by":"publisher","first-page":"4473","DOI":"10.1172\/JCI75276","volume":"124","author":"A Secher","year":"2014","unstructured":"Secher A, Jelsing J, Baquero AF, Hecksher-Sorensen J, Cowley MA, Dalboge LS, Hansen G, Grove KL, Pyke C, Raun K, Schaffer L, Tang-Christensen M, Verma S, Witgen BM, Vrang N, Bjerre Knudsen L (2014) The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest 124:4473\u20134488. https:\/\/doi.org\/10.1172\/JCI75276","journal-title":"J Clin Invest"},{"key":"1096_CR28","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s12974-019-1638-6","volume":"16","author":"Y Shan","year":"2019","unstructured":"Shan Y, Tan S, Lin Y, Liao S, Zhang B, Chen X, Wang J, Deng Z, Zeng Q, Zhang L, Wang Y, Hu X, Qiu W, Peng L, Lu Z (2019) The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke. J Neuroinflammation 16:242. https:\/\/doi.org\/10.1186\/s12974-019-1638-6","journal-title":"J Neuroinflammation"},{"key":"1096_CR29","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1038\/jcbfm.2011.196","volume":"32","author":"AY Shih","year":"2012","unstructured":"Shih AY, Driscoll JD, Drew PJ, Nishimura N, Schaffer CB, Kleinfeld D (2012) Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain. J Cereb Blood Flow Metab 32:1277\u20131309. https:\/\/doi.org\/10.1038\/jcbfm.2011.196","journal-title":"J Cereb Blood Flow Metab"},{"key":"1096_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109558","volume":"36","author":"CJ Tsai","year":"2021","unstructured":"Tsai CJ, Nagata T, Liu CY, Suganuma T, Kanda T, Miyazaki T, Liu K, Saitoh T, Nagase H, Lazarus M, Vogt KE, Yanagisawa M, Hayashi Y (2021) Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors. Cell Rep 36:109558. https:\/\/doi.org\/10.1016\/j.celrep.2021.109558","journal-title":"Cell Rep"},{"key":"1096_CR31","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S1474-4422(22)00519-1","volume":"22","author":"G Tsivgoulis","year":"2023","unstructured":"Tsivgoulis G, Katsanos AH, Sandset EC, Turc G, Nguyen TN, Bivard A, Fischer U, Khatri P (2023) Thrombolysis for acute ischaemic stroke: current status and future perspectives. Lancet Neurol 22:418\u2013429. https:\/\/doi.org\/10.1016\/S1474-4422(22)00519-1","journal-title":"Lancet Neurol"},{"key":"1096_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175390","volume":"940","author":"L Wang","year":"2023","unstructured":"Wang L, Wang Y, Chen Y, Liu B, Chou D, Bian X, Li R, Wang M, Zheng C (2023) Rhynchophylline ameliorates cerebral ischemia by improving the synaptic plasticity in a middle cerebral artery occlusion induced stroke model. Eur J Pharmacol 940:175390. https:\/\/doi.org\/10.1016\/j.ejphar.2022.175390","journal-title":"Eur J Pharmacol"},{"key":"1096_CR33","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1161\/STROKEAHA.122.042109","volume":"54","author":"DM Williams","year":"2023","unstructured":"Williams DM, Atkinson M, Evans M (2023) Stroke Prevention and treatment in people with type 2 diabetes: is there a role for GLP-1 (glucagon-like peptide-1) analogues? Stroke 54:1441\u20131451. https:\/\/doi.org\/10.1161\/STROKEAHA.122.042109","journal-title":"Stroke"},{"key":"1096_CR34","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1111\/bph.15059","volume":"177","author":"R Zhai","year":"2020","unstructured":"Zhai R, Xu H, Hu F, Wu J, Kong X, Sun X (2020) Exendin-4, a GLP-1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia-reperfusion injury. Br J Pharmacol 177:3389\u20133402. https:\/\/doi.org\/10.1111\/bph.15059","journal-title":"Br J Pharmacol"},{"key":"1096_CR35","doi-asserted-by":"publisher","first-page":"943","DOI":"10.14336\/AD.2021.1029","volume":"13","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Liu C, Shi R, Zhou S, Shan H, Deng L, Chen T, Guo Y, Zhang Z, Yang GY, Wang Y, Tang Y (2022) Blocking C3d(+)\/GFAP(+) A1 astrocyte conversion with semaglutide attenuates blood-brain barrier disruption in mice after ischemic stroke. Aging Dis 13:943\u2013959. https:\/\/doi.org\/10.14336\/AD.2021.1029","journal-title":"Aging Dis"},{"key":"1096_CR36","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1177\/0271678X16674736","volume":"37","author":"L Zhu","year":"2017","unstructured":"Zhu L, Wang L, Ju F, Ran Y, Wang C, Zhang S (2017) Transient global cerebral ischemia induces rapid and sustained reorganization of synaptic structures. J Cereb Blood Flow Metab 37:2756\u20132767. https:\/\/doi.org\/10.1177\/0271678X16674736","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-025-01096-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-025-01096-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-025-01096-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T07:00:23Z","timestamp":1744009223000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-025-01096-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,23]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["1096"],"URL":"https:\/\/doi.org\/10.1007\/s00395-025-01096-y","relation":{},"ISSN":["1435-1803"],"issn-type":[{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,23]]},"assertion":[{"value":"19 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}