{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:21:06Z","timestamp":1792819266388,"version":"4.5.0"},"reference-count":196,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/21\/10798"],"award-info":[{"award-number":["PG\/21\/10798"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Malaysian Government"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Although reperfusion therapy such as percutaneous coronary intervention and thrombolysis have been implemented in clinical practise as treatments for acute myocardial infarction (AMI) since the 1970s, patients continue to experience high rates of morbidity and mortality. Coronary reperfusion is effective as it limits infarction. However, it induces significant myocardial injury, known as ischaemia-reperfusion (IR) injury. Sustained depletion of cellular adenosine triphosphate (ATP) leading to intracellular calcium (Ca<jats:sup>2+<\/jats:sup>) overload ultimately lead to cardiomyocyte death during ischaemia. Reperfusion enables resynthesis of ATP, but if this occurs whilst Ca<jats:sup>2+<\/jats:sup> remains elevated, it induces excessive cardiomyocyte contracture, known as hypercontracture. Irreversible myocardial injury caused by hypercontracture is often accompanied by histological findings such as wavy myocardial fibres, and more profoundly, contraction band necrosis, identified by the presence of dense eosinophilic bands within the cardiomyocytes. The presence of hypercontracture imposes deleterious effects on both cardiac function and clinical outcomes in individuals experiencing AMI. The potential cardioprotective benefits of inhibiting hypercontracture following IR injury have been demonstrated in animal models, however therapies suitable for clinical application are yet to be developed. This article reviews the pathogenesis and clinical manifestation of hypercontracture in cardiomyocytes during AMI. In addition, the discussion highlights the challenges of translating robust pre-clinical data into successful clinical therapeutic approaches.<\/jats:p>","DOI":"10.1007\/s00395-025-01120-1","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T08:33:36Z","timestamp":1749285216000},"page":"619-639","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The contribution of cardiomyocyte hypercontracture to the burden of acute myocardial infarction: an update"],"prefix":"10.1007","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5826-328X","authenticated-orcid":false,"given":"Nur Liyana Mohammed","family":"Yusof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-9320","authenticated-orcid":false,"given":"Derek M.","family":"Yellon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5182-4980","authenticated-orcid":false,"given":"Sean M.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"1120_CR1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.cardiores.2006.02.020","volume":"70","author":"Y Abdallah","year":"2006","unstructured":"Abdallah Y, Gkatzoflia A, Gligorievski D, Kasseckert S, Euler G, Schl\u00fcter K-D, Sch\u00e4fer M, Piper H-M, Sch\u00e4fer C (2006) Insulin protects cardiomyocytes against reoxygenation-induced hypercontracture by a survival pathway targeting SR Ca2+ storage. Cardiovasc Res 70:346\u2013353. https:\/\/doi.org\/10.1016\/j.cardiores.2006.02.020","journal-title":"Cardiovasc Res"},{"key":"1120_CR2","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1042\/bj2440381","volume":"244","author":"A Allshire","year":"1987","unstructured":"Allshire A, Piper HM, Cuthbertson K, Cobbold PH (1987) Cytosolic free Ca2+ in single rat heart cells during anoxia and reoxygenation. Biochem J 244:381\u2013385. https:\/\/doi.org\/10.1042\/bj2440381","journal-title":"Biochem J"},{"key":"1120_CR3","doi-asserted-by":"publisher","first-page":"14325","DOI":"10.1016\/S0021-9258(17)38721-5","volume":"260","author":"RA Altschuld","year":"1985","unstructured":"Altschuld RA, Wenger W, Lamka K, Kindig O, Capen C, Mizuhira V, Vander Heide R, Brierley G (1985) Structural and functional properties of adult rat heart myocytes lysed with digitonin. J Biol Chem 260:14325\u201314334. https:\/\/doi.org\/10.1016\/S0021-9258(17)38721-5","journal-title":"J Biol Chem"},{"key":"1120_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-018-0692-z","volume":"113","author":"JP Audia","year":"2018","unstructured":"Audia JP, Yang X-M, Crockett ES, Housley N, Haq EU, O\u2019Donnell K, Cohen MV, Downey JM, Alvarez DF (2018) Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y 12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function. Basic Res Cardiol 113:1\u201315. https:\/\/doi.org\/10.1007\/s00395-018-0692-z","journal-title":"Basic Res Cardiol"},{"key":"1120_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.109558","volume":"137","author":"A Barzyc","year":"2020","unstructured":"Barzyc A, \u0141ysik W, S\u0142yk J, Kuszewski M, Zar\u0119bi\u0144ski M, Wojciechowska M, Cudnoch-J\u0119drzejewska A (2020) Reperfusion injury as a target for diminishing infarct size. Med Hypotheses 137:109558. https:\/\/doi.org\/10.1016\/j.mehy.2020.109558","journal-title":"Med Hypotheses"},{"key":"1120_CR6","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1136\/hrt.2005.086959","volume":"92","author":"C Basso","year":"2006","unstructured":"Basso C, Thiene G (2006) The pathophysiology of myocardial reperfusion: a pathologist\u2019s perspective. Heart 92:1559\u20131562. https:\/\/doi.org\/10.1136\/hrt.2005.086959","journal-title":"Heart"},{"key":"1120_CR7","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.yjmcc.2014.09.023","volume":"78","author":"P Bernardi","year":"2015","unstructured":"Bernardi P, Di Lisa F (2015) The mitochondrial permeability transition pore: molecular nature and role as a target in cardioprotection. J Mol Cell Cardiol 78:100\u2013106. https:\/\/doi.org\/10.1016\/j.yjmcc.2014.09.023","journal-title":"J Mol Cell Cardiol"},{"key":"1120_CR8","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","volume":"18","author":"D Bertheloot","year":"2021","unstructured":"Bertheloot D, Latz E, Franklin BS (2021) Necroptosis, pyroptosis and apoptosis: an intricate game of cell death. Cell Mol Immunol 18:1106\u20131121. https:\/\/doi.org\/10.1038\/s41423-020-00630-3","journal-title":"Cell Mol Immunol"},{"key":"1120_CR9","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nrcardio.2014.188","volume":"12","author":"RP Betgem","year":"2015","unstructured":"Betgem RP, De Waard GA, Nijveldt R, Beek AM, Escaned J, Van Royen N (2015) Intramyocardial haemorrhage after acute myocardial infarction. Nat Rev Cardiol 12:156\u2013167. https:\/\/doi.org\/10.1038\/nrcardio.2014.188","journal-title":"Nat Rev Cardiol"},{"key":"1120_CR10","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s00395-010-0124-1","volume":"105","author":"K Boengler","year":"2010","unstructured":"Boengler K, Hilfiker-Kleiner D, Heusch G, Schulz R (2010) Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia\/reperfusion. Basic Res Cardiol 105:771\u201385. https:\/\/doi.org\/10.1007\/s00395-010-0124-1","journal-title":"Basic Res Cardiol"},{"key":"1120_CR11","doi-asserted-by":"publisher","first-page":"6890","DOI":"10.2174\/138161281939131127115940","volume":"19","author":"K Boengler","year":"2013","unstructured":"Boengler K, Ungefug E, Heusch G, Schulz R (2013) The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation. Curr Pharm Des 19:6890\u20136895. https:\/\/doi.org\/10.2174\/138161281939131127115940","journal-title":"Curr Pharm Des"},{"key":"1120_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-018-0696-8","volume":"113","author":"HE B\u00f8tker","year":"2018","unstructured":"B\u00f8tker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:1\u201373. https:\/\/doi.org\/10.1007\/s00395-018-0696-8","journal-title":"Basic Res Cardiol"},{"key":"1120_CR13","first-page":"301","volume":"74","author":"B Bouchardy","year":"1974","unstructured":"Bouchardy B, Majno G (1974) Histopathology of early myocardial infarcts: a new approach. Am J Pathol 74:301","journal-title":"Am J Pathol"},{"key":"1120_CR14","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1161\/CIRCRESAHA.117.311082","volume":"120","author":"JM Bravo-San Pedro","year":"2017","unstructured":"Bravo-San Pedro JM, Kroemer G, Galluzzi L (2017) Autophagy and mitophagy in cardiovascular disease. Circ Res 120:1812\u20131824. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.311082","journal-title":"Circ Res"},{"key":"1120_CR15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0003-9861(64)90239-5","volume":"105","author":"G Brierley","year":"1964","unstructured":"Brierley G, Murer E, Bachmann E (1964) Studies on ion transport: III. The accumulation of calcium and inorganic phosphate by heart mitochondria. Arch Biochem Biophys 105:89\u2013102. https:\/\/doi.org\/10.1016\/0003-9861(64)90239-5","journal-title":"Arch Biochem Biophys"},{"key":"1120_CR16","first-page":"1345","volume":"78","author":"LM Buja","year":"1998","unstructured":"Buja LM (1998) Modulation of the myocardial response to ischemia. Lab Inves 78:1345\u20131373","journal-title":"Lab Inves"},{"key":"1120_CR17","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.carpath.2005.03.006","volume":"14","author":"LM Buja","year":"2005","unstructured":"Buja LM (2005) Myocardial ischemia and reperfusion injury. Cardiovasc Pathol 14:170\u2013175. https:\/\/doi.org\/10.1016\/j.carpath.2005.03.006","journal-title":"Cardiovasc Pathol"},{"key":"1120_CR18","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1161\/01.cir.56.6.906","volume":"56","author":"B Bulkely","year":"1977","unstructured":"Bulkely B, Hutchins GM (1977) Myocardial consequences of coronary artery bypass graft surgery. The paradox of necrosis in areas of revascularization. Circulation 56:906\u2013913. https:\/\/doi.org\/10.1161\/01.cir.56.6.906","journal-title":"Circulation"},{"key":"1120_CR19","doi-asserted-by":"publisher","first-page":"H1069","DOI":"10.1152\/ajpheart.00694.2010","volume":"300","author":"M Cai","year":"2011","unstructured":"Cai M, Li Y, Xu Y, Swartz HM, Chen C-L, Chen Y-R, He G (2011) Endothelial NOS activity and myocardial oxygen metabolism define the salvageable ischemic time window for ischemic postconditioning. Am J Physiol Heart Circ Physiol 300:H1069\u2013H1077. https:\/\/doi.org\/10.1152\/ajpheart.00694.2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1120_CR20","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002834","volume":"5","author":"D Carrick","year":"2016","unstructured":"Carrick D, Haig C, Ahmed N, Rauhalammi S, Clerfond G, Carberry J, Mordi I, McEntegart M, Petrie MC, Eteiba H (2016) Temporal evolution of myocardial hemorrhage and edema in patients after acute ST-segment elevation myocardial infarction: pathophysiological insights and clinical implications. J Am Heart Assoc 5:e002834. https:\/\/doi.org\/10.1161\/JAHA.115.002834","journal-title":"J Am Heart Assoc"},{"key":"1120_CR21","first-page":"489","volume":"35","author":"J Caulfield","year":"1959","unstructured":"Caulfield J, Klionsky B (1959) Myocardial ischemia and early infarction; an electron microscopic study. Am J Pathol 35:489\u2013523","journal-title":"Am J Pathol"},{"key":"1120_CR22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mpdhp.2012.11.001","volume":"19","author":"J Chang","year":"2013","unstructured":"Chang J, Nair V, Luk A, Butany J (2013) Pathology of myocardial infarction. Diagn Histopathol 19:7\u201312. https:\/\/doi.org\/10.1016\/j.mpdhp.2012.11.001","journal-title":"Diagn Histopathol"},{"key":"1120_CR23","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.ijcard.2012.10.050","volume":"168","author":"S Chatterjee","year":"2013","unstructured":"Chatterjee S, Chaudhuri D, Vedanthan R, Fuster V, Ibanez B, Bangalore S, Mukherjee D (2013) Early intravenous beta-blockers in patients with acute coronary syndrome\u2014a meta-analysis of randomized trials. Int J Cardiol 168:915\u2013921. https:\/\/doi.org\/10.1016\/j.ijcard.2012.10.050","journal-title":"Int J Cardiol"},{"key":"1120_CR24","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s10495-017-1358-2","volume":"22","author":"S Chen","year":"2017","unstructured":"Chen S, Lv X, Hu B, Shao Z, Wang B, Ma K, Lin H, Cui M (2017) RIPK1\/RIPK3\/MLKL-mediated necroptosis contributes to compression-induced rat nucleus pulposus cells death. Apoptosis 22:626\u2013638. https:\/\/doi.org\/10.1007\/s10495-017-1358-2","journal-title":"Apoptosis"},{"key":"1120_CR25","first-page":"203","volume":"11","author":"D Cooley","year":"1975","unstructured":"Cooley D, Reul G Jr, Wukasch D (1975) Ischemic myocardial contracture (\u201c stone heart\u201d). A complication of cardiac surgery. Isr J Med Sci 11:203\u2013210","journal-title":"Isr J Med Sci"},{"key":"1120_CR26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s10863-009-9213-y","volume":"41","author":"AD Costa","year":"2009","unstructured":"Costa AD, Garlid KD (2009) MitoK ATP activity in healthy and ischemic hearts. J Bioenerg Biomembr 41:123\u2013126. https:\/\/doi.org\/10.1007\/s10863-009-9213-y","journal-title":"J Bioenerg Biomembr"},{"key":"1120_CR27","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1042\/bss0660167","volume":"66","author":"M Crompton","year":"1999","unstructured":"Crompton M, Virji S, Doyle V, Johnson N, Ward JM (1999) The mitochondrial permeability transition pore. Biochem Soc Symp 66:167\u2013179. https:\/\/doi.org\/10.1042\/bss0660167","journal-title":"Biochem Soc Symp"},{"key":"1120_CR28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2021.01.036","volume":"165","author":"M Dambrova","year":"2021","unstructured":"Dambrova M, Zuurbier CJ, Borutaite V, Liepinsh E, Makrecka-Kuka M (2021) Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia\/reperfusion injury. Free Radic Biol Med 165:24\u201337. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.01.036","journal-title":"Free Radic Biol Med"},{"key":"1120_CR29","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/0002-9149(90)90351-z","volume":"66","author":"Danish Study Group on Verapamil in Myocardial Infarction","year":"1990","unstructured":"Danish Study Group on Verapamil in Myocardial Infarction (1990) Effect of verapamil on mortality and major events after acute myocardial infarction (The Danish Verapamil Infarction Trial II\u2014DAVIT II). Am J Cardiol 66:779\u2013785. https:\/\/doi.org\/10.1016\/0002-9149(90)90351-z","journal-title":"Am J Cardiol"},{"key":"1120_CR30","doi-asserted-by":"publisher","first-page":"3795","DOI":"10.1111\/jcmm.15127","volume":"24","author":"SM Davidson","year":"2020","unstructured":"Davidson SM, Adameov\u00e1 A, Barile L, Cabrera-Fuentes HA, Lazou A, Pagliaro P, Stensl\u00f8kken KO, Garcia-Dorado D (2020) Mitochondrial and mitochondrial-independent pathways of myocardial cell death during ischaemia and reperfusion injury. J Cell Mol Med 24:3795\u20133806. https:\/\/doi.org\/10.1111\/jcmm.15127","journal-title":"J Cell Mol Med"},{"key":"1120_CR31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","volume":"73","author":"SM Davidson","year":"2019","unstructured":"Davidson SM, Ferdinandy P, Andreadou I, B\u00f8tker HE, Heusch G, Ib\u00e1\u00f1ez B, Ovize M, Schulz R, Yellon DM, Hausenloy DJ (2019) Multitarget strategies to reduce myocardial ischemia\/reperfusion injury: JACC review topic of the week. J Am Col Cardiol 73:89\u201399. https:\/\/doi.org\/10.1016\/j.jacc.2018.09.086","journal-title":"J Am Col Cardiol"},{"key":"1120_CR32","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.biocel.2005.09.017","volume":"38","author":"SM Davidson","year":"2006","unstructured":"Davidson SM, Hausenloy D, Duchen MR, Yellon DM (2006) Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection. Int J Biochem Cell Biol 38:414\u2013419. https:\/\/doi.org\/10.1016\/j.biocel.2005.09.017","journal-title":"Int J Biochem Cell Biol"},{"key":"1120_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2024.101528","volume":"4","author":"R Dharmakumar","year":"2025","unstructured":"Dharmakumar R, Kloner RA, Fishbein M, Heusch G, Vora KP, Gropler R, Henry T, Chan SF, Singh D, Jambunathan N, Subramanian R (2025) Reperfused Myocardial Infarction: the Road to CCS Classification of Acute MI and Beyond. JACC Adv 4:101528. https:\/\/doi.org\/10.1016\/j.jacadv.2024.101528","journal-title":"JACC Adv"},{"key":"1120_CR34","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","volume":"20","author":"X Fang","year":"2023","unstructured":"Fang X, Ardehali H, Min J, Wang F (2023) The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease. Nat Rev Cardiol 20:7\u201323. https:\/\/doi.org\/10.1038\/s41569-022-00735-4","journal-title":"Nat Rev Cardiol"},{"key":"1120_CR35","first-page":"271","volume":"102","author":"J Farber","year":"1981","unstructured":"Farber J, Chien K, Mittnacht S Jr (1981) Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia. Am J Pathol 102:271","journal-title":"Am J Pathol"},{"key":"1120_CR36","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/clc.4960130312","volume":"13","author":"M Fishbein","year":"1990","unstructured":"Fishbein M (1990) Reperfusion injury. Clin Cardiol 13:213\u2013217. https:\/\/doi.org\/10.1002\/clc.4960130312","journal-title":"Clin Cardiol"},{"key":"1120_CR37","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2013.02.003","volume":"228","author":"MA Frias","year":"2013","unstructured":"Frias MA, Pedretti S, Hacking D, Somers S, Lacerda L, Opie LH, James RW, Lecour S (2013) HDL protects against ischemia reperfusion injury by preserving mitochondrial integrity. Atherosclerosis 228:110\u2013116. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.02.003","journal-title":"Atherosclerosis"},{"key":"1120_CR38","doi-asserted-by":"publisher","unstructured":"Ganote C, CE G (1983) Contraction band necrosis and irreversible myocardial injury. J Mol Cell Cardiol 15:67\u201373 https:\/\/doi.org\/10.1016\/0022-2828(83)90283-3","DOI":"10.1016\/0022-2828(83)90283-3"},{"key":"1120_CR39","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.yjmcc.2012.01.010","volume":"52","author":"D Garcia-Dorado","year":"2012","unstructured":"Garcia-Dorado D, Andres-Villarreal M, Ruiz-Meana M, Inserte J, Barba I (2012) Myocardial edema: a translational view. J Mol Cell Cardiol 52:931\u2013939. https:\/\/doi.org\/10.1016\/j.yjmcc.2012.01.010","journal-title":"J Mol Cell Cardiol"},{"key":"1120_CR40","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1161\/01.cir.96.10.3579","volume":"96","author":"D Garcia-Dorado","year":"1997","unstructured":"Garcia-Dorado D, Inserte J, Ruiz-Meana M, Gonz\u00e1lez MA, Solares J, Juli\u00e1 M, Barrab\u00e9s JA, Soler-Soler J (1997) Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion. Circulation 96:3579\u20133586. https:\/\/doi.org\/10.1161\/01.cir.96.10.3579","journal-title":"Circulation"},{"key":"1120_CR41","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1093\/cvr\/cvs116","volume":"94","author":"D Garcia-Dorado","year":"2012","unstructured":"Garcia-Dorado D, Ruiz-Meana M, Inserte J, Rodriguez-Sinovas A, Piper HM (2012) Calcium-mediated cell death during myocardial reperfusion. Cardiovasc Res 94:168\u2013180. https:\/\/doi.org\/10.1093\/cvr\/cvs116","journal-title":"Cardiovasc Res"},{"key":"1120_CR42","doi-asserted-by":"publisher","first-page":"H1266","DOI":"10.1152\/ajpheart.1989.256.5.H1266","volume":"256","author":"D Garcia-Dorado","year":"1989","unstructured":"Garcia-Dorado D, Theroux P, Desco M, Solares J, Elizaga J, Fernandez-Aviles F, Alonso J, Soriano J (1989) Cell-to-cell interaction: a mechanism to explain wave-front progression of myocardial necrosis. Am J Physiol 256:H1266\u2013H1273. https:\/\/doi.org\/10.1152\/ajpheart.1989.256.5.H1266","journal-title":"Am J Physiol"},{"key":"1120_CR43","doi-asserted-by":"publisher","first-page":"14780","DOI":"10.1038\/ncomms14780","volume":"8","author":"J Garc\u00eda-Prieto","year":"2017","unstructured":"Garc\u00eda-Prieto J, Villena-Guti\u00e9rrez R, G\u00f3mez M, Bernardo E, Pun-Garc\u00eda A, Garc\u00eda-Lunar I, Crainiciuc G, Fern\u00e1ndez-Jim\u00e9nez R, Sreeramkumar V, Bourio-Mart\u00ednez R, Garc\u00eda-Ruiz JM (2017) Neutrophil stunning by metoprolol reduces infarct size. Nat Commun 8:14780. https:\/\/doi.org\/10.1038\/ncomms14780","journal-title":"Nat Commun"},{"key":"1120_CR44","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1016\/j.jacc.2016.02.050","volume":"67","author":"JM Garc\u00eda-Ruiz","year":"2016","unstructured":"Garc\u00eda-Ruiz JM, Fern\u00e1ndez-Jim\u00e9nez R, Garc\u00eda-Alvarez A, Pizarro G, Gal\u00e1n-Arriola C, Fern\u00e1ndez-Friera L, Mateos A, Nuno-Ayala M, Aguero J, S\u00e1nchez-Gonz\u00e1lez J (2016) Impact of the timing of metoprolol administration during STEMI on infarct size and ventricular function. J Am Col Cardiol 67:2093\u20132104. https:\/\/doi.org\/10.1016\/j.jacc.2016.02.050","journal-title":"J Am Col Cardiol"},{"key":"1120_CR45","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1161\/01.cir.83.1.52","volume":"83","author":"RE Goldstein","year":"1991","unstructured":"Goldstein RE, Boccuzzi SJ, Cruess D, Nattel S (1991) Diltiazem increases late-onset congestive heart failure in postinfarction patients with early reduction in ejection fraction. The Adverse Experience Committee; and the Multicenter Diltiazem Postinfarction Research Group. Circulation 83:52\u201360. https:\/\/doi.org\/10.1161\/01.cir.83.1.52","journal-title":"Circulation"},{"key":"1120_CR46","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41586-023-05972-2","volume":"618","author":"GQ Gong","year":"2023","unstructured":"Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D (2023) A small-molecule PI3K\u03b1 activator for cardioprotection and neuroregeneration. Nature 618:159\u2013168. https:\/\/doi.org\/10.1038\/s41586-023-05972-2","journal-title":"Nature"},{"key":"1120_CR47","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012429","volume":"8","author":"S Greulich","year":"2019","unstructured":"Greulich S, Mayr A, Gloekler S, Seitz A, Birkmeier S, Sch\u00e4ufele T, Bekeredjian R, Zuern CS, Seizer P, Geisler T (2019) Time-dependent myocardial necrosis in patients with ST-segment\u2013elevation myocardial infarction without angiographic collateral flow visualized by cardiac magnetic resonance imaging: results from the multicenter STEMI-SCAR project. J Am Heart Assoc 8:e012429. https:\/\/doi.org\/10.1161\/JAHA.119.012429","journal-title":"J Am Heart Assoc"},{"key":"1120_CR48","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/s44161-022-00094-w","volume":"1","author":"J Grune","year":"2022","unstructured":"Grune J, Lewis AJ, Yamazoe M, Hulsmans M, Rohde D, Xiao L, Zhang S, Ott C, Calcagno DM, Zhou Y, Timm K (2022) Neutrophils incite and macrophages avert electrical storm after myocardial infarction. Nat Cardiovasc Res 1:649\u2013664. https:\/\/doi.org\/10.1038\/s44161-022-00094-w","journal-title":"Nat Cardiovasc Res"},{"key":"1120_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009528","volume":"5","author":"YS Han","year":"2010","unstructured":"Han YS, Ogut O (2010) Regulation of fibre contraction in a rat model of myocardial ischemia. PLoS One 5:e9528. https:\/\/doi.org\/10.1371\/journal.pone.0009528","journal-title":"PLoS One"},{"key":"1120_CR50","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1006\/jmcc.1999.1029","volume":"31","author":"M Hartmann","year":"1999","unstructured":"Hartmann M, Decking U (1999) Blocking Na+\u2013H+ exchange by cariporide reduces Na+-overload in ischemia and is cardioprotective. JJ Mol Cell Cardiol 31:1985\u20131995. https:\/\/doi.org\/10.1006\/jmcc.1999.1029","journal-title":"JJ Mol Cell Cardiol"},{"key":"1120_CR51","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1161\/01.CIR.0000126294.81407.7D","volume":"109","author":"D Hausenloy","year":"2004","unstructured":"Hausenloy D, Wynne A, Duchen M, Yellon D (2004) Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection. Circulation 109:1714\u20131717. https:\/\/doi.org\/10.1161\/01.CIR.0000126294.81407.7D","journal-title":"Circulation"},{"key":"1120_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-016-0588-8","volume":"111","author":"DJ Hausenloy","year":"2016","unstructured":"Hausenloy DJ, Barrabes JA, B\u00f8tker HE, Davidson SM, Di Lisa F, Downey J, Engstrom T, Ferdinandy P, Carbrera-Fuentes HA, Heusch G, Ibanez B (2016) Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery. Basic Res Cardiol 111:1\u201324. https:\/\/doi.org\/10.1007\/s00395-016-0588-8","journal-title":"Basic Res Cardiol"},{"key":"1120_CR53","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.cardiores.2003.09.025","volume":"60","author":"DJ Hausenloy","year":"2003","unstructured":"Hausenloy DJ, Duchen MR, Yellon DM (2003) Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia\u2013reperfusion injury. Cardiovasc Res 60:617\u2013625. https:\/\/doi.org\/10.1016\/j.cardiores.2003.09.025","journal-title":"Cardiovasc Res"},{"key":"1120_CR54","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/cvr\/cvx049","volume":"113","author":"DJ Hausenloy","year":"2017","unstructured":"Hausenloy DJ, Garcia-Dorado D, B\u00f8tker HE, Davidson SM, Downey J, Engel FB, Jennings R, Lecour S, Leor J, Madonna R (2017) Novel targets and future strategies for acute cardioprotection: position paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovasc Res 113:564\u2013585. https:\/\/doi.org\/10.1093\/cvr\/cvx049","journal-title":"Cardiovasc Res"},{"key":"1120_CR55","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00395-009-0010-x","volume":"104","author":"DJ Hausenloy","year":"2009","unstructured":"Hausenloy DJ, Ong S-B, Yellon DM (2009) The mitochondrial permeability transition pore as a target for preconditioning and postconditioning. Basic Res Cardiol 104:189\u2013202. https:\/\/doi.org\/10.1007\/s00395-009-0010-x","journal-title":"Basic Res Cardiol"},{"key":"1120_CR56","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.pharmthera.2007.06.005","volume":"116","author":"DJ Hausenloy","year":"2007","unstructured":"Hausenloy DJ, Yellon DM (2007) Preconditioning and postconditioning: united at reperfusion. Pharmacol Ther 116:173\u2013191. https:\/\/doi.org\/10.1016\/j.pharmthera.2007.06.005","journal-title":"Pharmacol Ther"},{"key":"1120_CR57","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s10557-010-6237-9","volume":"24","author":"DJ Hausenloy","year":"2010","unstructured":"Hausenloy DJ, Yellon DM (2010) The second window of preconditioning (SWOP) where are we now? Cardiovasc Drugs Ther 24:235\u2013254. https:\/\/doi.org\/10.1007\/s10557-010-6237-9","journal-title":"Cardiovasc Drugs Ther"},{"key":"1120_CR58","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nrcardio.2011.85","volume":"8","author":"DJ Hausenloy","year":"2011","unstructured":"Hausenloy DJ, Yellon DM (2011) The therapeutic potential of ischemic conditioning: an update. Nat Rev Cardiol 8:619\u2013629. https:\/\/doi.org\/10.1038\/nrcardio.2011.85","journal-title":"Nat Rev Cardiol"},{"key":"1120_CR59","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/JCI62874","volume":"123","author":"DJ Hausenloy","year":"2013","unstructured":"Hausenloy DJ, Yellon DM (2013) Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest 123:92\u2013100. https:\/\/doi.org\/10.1172\/JCI62874","journal-title":"J Clin Invest"},{"key":"1120_CR60","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1161\/01.res.49.5.1119","volume":"49","author":"RA Haworth","year":"1981","unstructured":"Haworth RA, Hunter DR, Berkoff HA (1981) Contracture in isolated adult rat heart cells. Role of Ca2+, ATP, and compartmentation. Circ Res 49:1119\u20131128. https:\/\/doi.org\/10.1161\/01.res.49.5.1119","journal-title":"Circ Res"},{"key":"1120_CR61","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/0022-2828(73)90030-8","volume":"5","author":"D Hearse","year":"1973","unstructured":"Hearse D, Humphrey S, Chain E (1973) Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: a study of myocardial enzyme release. J Mol Cell Cardiol 5:395\u2013407. https:\/\/doi.org\/10.1016\/0022-2828(73)90030-8","journal-title":"J Mol Cell Cardiol"},{"key":"1120_CR62","first-page":"367","volume":"46","author":"PB Herdson","year":"1965","unstructured":"Herdson PB, Sommers HM, Jennings RB (1965) A comparative study of the fine structure of normal and ischemic dog myocardium with special reference to early changes following temporary occlusion of a coronary artery. Am J Pathol 46:367","journal-title":"Am J Pathol"},{"key":"1120_CR63","doi-asserted-by":"publisher","first-page":"6571","DOI":"10.1111\/jcmm.15384","volume":"24","author":"S Hernandez-Resendiz","year":"2020","unstructured":"Hernandez-Resendiz S, Prunier F, Girao H, Dorn G, Hausenloy DJ (2020) Targeting mitochondrial fusion and fission proteins for cardioprotection. J Cell Mol Med 24:6571\u20136585. https:\/\/doi.org\/10.1111\/jcmm.15384","journal-title":"J Cell Mol Med"},{"key":"1120_CR64","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/220079a0","volume":"220","author":"ML Hess","year":"1968","unstructured":"Hess ML, Briggs FN, Shinebourne E, Hamer J (1968) Effect of adrenergic blocking agents on the calcium pump of the fragmented cardiac sarcoplasmic reticulum. Nature 220:79\u201380. https:\/\/doi.org\/10.1038\/220079a0","journal-title":"Nature"},{"key":"1120_CR65","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/CIRCRESAHA.116.305348","volume":"116","author":"G Heusch","year":"2015","unstructured":"Heusch G (2015) Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res 116:674\u2013699. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.305348","journal-title":"Circ Res"},{"issue":"10","key":"1120_CR66","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1161\/CIRCRESAHA.116.308640","volume":"118","author":"G Heusch","year":"2016","unstructured":"Heusch G (2016) The coronary circulation as a target of cardioprotection. Circ Res 118(10):1643\u20131658. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.308640","journal-title":"Circ Res"},{"key":"1120_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-019-0756-8","volume":"114","author":"G Heusch","year":"2019","unstructured":"Heusch G (2019) Coronary microvascular obstruction: the new frontier in cardioprotection. Basic Res Cardiol 114:1\u201313. https:\/\/doi.org\/10.1007\/s00395-019-0756-8","journal-title":"Basic Res Cardiol"},{"key":"1120_CR68","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","volume":"17","author":"G Heusch","year":"2020","unstructured":"Heusch G (2020) Myocardial ischaemia\u2013reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17:773\u2013789. https:\/\/doi.org\/10.1038\/s41569-020-0403-y","journal-title":"Nat Rev Cardiol"},{"key":"1120_CR69","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.medj.2023.12.007","volume":"5","author":"G Heusch","year":"2024","unstructured":"Heusch G (2024) Myocardial ischemia\/reperfusion: Translational pathophysiology of ischemic heart disease. Med 5:10\u201331. https:\/\/doi.org\/10.1016\/j.medj.2023.12.007","journal-title":"Med"},{"key":"1120_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102894","volume":"67","author":"G Heusch","year":"2023","unstructured":"Heusch G, Andreadou I, Bell R, Bertero E, Botker HE, Davidson SM, Downey J, Eaton P, Ferdinandy P, Gersh BJ, Giacca M (2023) Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection. Redox Biol 67:102894. https:\/\/doi.org\/10.1016\/j.redox.2023.102894","journal-title":"Redox Biol"},{"key":"1120_CR71","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00395-009-0080-9","volume":"105","author":"G Heusch","year":"2010","unstructured":"Heusch G, Boengler K, Schulz R (2010) Inhibition of mitochondrial permeability transition pore opening: the Holy Grail of cardioprotection. Basic Res Cardiol 105:151\u2013154. https:\/\/doi.org\/10.1007\/s00395-009-0080-9","journal-title":"Basic Res Cardiol"},{"key":"1120_CR72","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1093\/eurheartj\/ehw224","volume":"38","author":"G Heusch","year":"2017","unstructured":"Heusch G, Gersh BJ (2017) The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge. Eur Heart J 38:774\u2013784. https:\/\/doi.org\/10.1093\/eurheartj\/ehw224","journal-title":"Eur Heart J"},{"key":"1120_CR73","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","volume":"383","author":"G Heusch","year":"2014","unstructured":"Heusch G, Libby P, Gersh B, Yellon D, B\u00f6hm M, Lopaschuk G, Opie L (2014) Cardiovascular remodelling in coronary artery disease and heart failure. Lancet 383:1933\u20131943. https:\/\/doi.org\/10.1016\/S0140-6736(14)60107-0","journal-title":"Lancet"},{"key":"1120_CR74","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1161\/CIRCRESAHA.111.255604","volume":"109","author":"G Heusch","year":"2011","unstructured":"Heusch G, Musiolik J, Gedik N, Skyschally A (2011) Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia\/reperfusion. Circ Res 109:1302\u20131308. https:\/\/doi.org\/10.1161\/CIRCRESAHA.111.255604","journal-title":"Circ Res"},{"key":"1120_CR75","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1161\/01.cir.65.1.62","volume":"65","author":"L Higginson","year":"1982","unstructured":"Higginson L, White F, Heggtveit H, Sanders T, Bloor C, Covell J (1982) Determinants of myocardial hemorrhage after coronary reperfusion in the anesthetized dog. Circulation 65:62\u201369. https:\/\/doi.org\/10.1161\/01.cir.65.1.62","journal-title":"Circulation"},{"key":"1120_CR76","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1136\/jcp.49.5.403","volume":"49","author":"D Hopster","year":"1996","unstructured":"Hopster D, Milroy C, Burns J, Roberts N (1996) Necropsy study of the association between sudden cardiac death, cardiac isoenzymes and contraction band necrosis. J Clin Pathol 49:403\u2013406. https:\/\/doi.org\/10.1136\/jcp.49.5.403","journal-title":"J Clin Pathol"},{"key":"1120_CR77","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/0003-9861(79)90371-0","volume":"195","author":"DR Hunter","year":"1979","unstructured":"Hunter DR, Haworth RA (1979) The Ca2+-induced membrane transition in mitochondria: I. The protective mechanisms. Arc Biochem Biophys 195:453\u2013459. https:\/\/doi.org\/10.1016\/0003-9861(79)90371-0","journal-title":"Arc Biochem Biophys"},{"key":"1120_CR78","first-page":"745","volume":"95","author":"G Hutchins","year":"1979","unstructured":"Hutchins G, Silverman K (1979) Pathology of the stone heart syndrome. Massive myocardial contraction band necrosis and widely patent coronary arteries. Am J Pathol 95:745","journal-title":"Am J Pathol"},{"issue":"7","key":"1120_CR79","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/0002-9149(78)90869-x","volume":"41","author":"GM Hutchins","year":"1978","unstructured":"Hutchins GM (1978) Bulkley BH (1978) Infarct expansion versus extension: two different complications of acute myocardial infarction. Am J Cardiol 41(7):1127\u20131132. https:\/\/doi.org\/10.1016\/0002-9149(78)90869-x","journal-title":"Am J Cardiol"},{"key":"1120_CR80","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.jacc.2015.02.032","volume":"65","author":"B Ib\u00e1\u00f1ez","year":"2015","unstructured":"Ib\u00e1\u00f1ez B, Heusch G, Ovize M, Van de Werf F (2015) Evolving therapies for myocardial ischemia\/reperfusion injury. J Am Coll Cardiol 65:1454\u20131471. https:\/\/doi.org\/10.1016\/j.jacc.2015.02.032","journal-title":"J Am Coll Cardiol"},{"key":"1120_CR81","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1161\/CIRCULATIONAHA.113.003653","volume":"128","author":"B Ibanez","year":"2013","unstructured":"Ibanez B, Macaya C, S\u00e1nchez-Brunete V, Pizarro G, Fern\u00e1ndez-Friera L, Mateos A, Fern\u00e1ndez-Ortiz A, Garc\u00eda-Ruiz JM, Garc\u00eda-\u00c1lvarez A, I\u00f1iguez A (2013) Effect of early metoprolol on infarct size in ST-segment\u2013elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: the effect of metoprolol in cardioprotection during an acute myocardial infarction (METOCARD-CNIC) trial. Circulation 128:1495\u20131503. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.003653","journal-title":"Circulation"},{"key":"1120_CR82","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/s0008-6363(02)00461-3","volume":"55","author":"J Inserte","year":"2002","unstructured":"Inserte J, Garcia-Dorado D, Ruiz-Meana M, Padilla F, Barrab\u00e9s JA, Pina P, Agull\u00f3 L, Piper HM, Soler-Soler J (2002) Effect of inhibition of Na+\/Ca2+ exchanger at the time of myocardial reperfusion on hypercontracture and cell death. Cardiovasc Res 55:739\u2013748. https:\/\/doi.org\/10.1016\/s0008-6363(02)00461-3","journal-title":"Cardiovasc Res"},{"key":"1120_CR83","first-page":"68","volume":"70","author":"RB Jennings","year":"1960","unstructured":"Jennings RB (1960) Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog. Arch Pathol 70:68\u201378","journal-title":"Arch Pathol"},{"key":"1120_CR84","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/0002-9149(69)90464-0","volume":"24","author":"RB Jennings","year":"1969","unstructured":"Jennings RB (1969) Early phase of myocardial ischemic injury and infarction. Am J Cardiol 24:753\u2013765. https:\/\/doi.org\/10.1016\/0002-9149(69)90464-0","journal-title":"Am J Cardiol"},{"key":"1120_CR85","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1161\/CIRCRESAHA.113.300987","volume":"113","author":"RB Jennings","year":"2013","unstructured":"Jennings RB (2013) Historical perspective on the pathology of myocardial ischemia\/reperfusion injury. Circ Res 113:428\u2013438. https:\/\/doi.org\/10.1161\/CIRCRESAHA.113.300987","journal-title":"Circ Res"},{"key":"1120_CR86","first-page":"241","volume":"102","author":"RB Jennings","year":"1981","unstructured":"Jennings RB, Reimer KA (1981) Lethal myocardial ischemic injury. Am J Pathol 102:241","journal-title":"Am J Pathol"},{"key":"1120_CR87","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1161\/circ.58.6.309363","volume":"58","author":"K Kayser","year":"1978","unstructured":"Kayser K (1978) Contraction band necrosis. Circulation 58:1212\u20133","journal-title":"Circulation"},{"key":"1120_CR88","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.jacasi.2023.02.006","volume":"3","author":"MH Kim","year":"2023","unstructured":"Kim MH, Yuan SL, Lee KM, Jin X, Song ZY, Cho Y-R, Lee MS, Kim JH, Jeong MH (2023) Clinical outcomes of calcium-channel blocker vs beta-blocker: from the Korean Acute Myocardial Infarction Registry. JACC Asia 3:446\u2013454. https:\/\/doi.org\/10.1016\/j.jacasi.2023.02.006","journal-title":"JACC Asia"},{"key":"1120_CR89","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s10974-019-09539-5","volume":"40","author":"A Kitmitto","year":"2019","unstructured":"Kitmitto A, Baudoin F, Cartwright EJ (2019) Cardiomyocyte damage control in heart failure and the role of the sarcolemma. J Muscle Res Cell Motil 40:319\u2013333. https:\/\/doi.org\/10.1007\/s10974-019-09539-5","journal-title":"J Muscle Res Cell Motil"},{"key":"1120_CR90","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s00395-020-0814-2","volume":"115","author":"P Kleinbongard","year":"2020","unstructured":"Kleinbongard P (2020) Cardioprotection by early metoprolol-attenuation of ischemic vs. reperfusion injury? Basic Res Cardiol 115:54. https:\/\/doi.org\/10.1007\/s00395-020-0814-2","journal-title":"Basic Res Cardiol"},{"key":"1120_CR91","doi-asserted-by":"publisher","first-page":"3511","DOI":"10.1093\/eurheartj\/ehx288","volume":"38","author":"RA Kloner","year":"2017","unstructured":"Kloner RA (2017) The importance of no-reflow\/microvascular obstruction in the STEMI patient. Eur Heart J 38:3511\u20133513. https:\/\/doi.org\/10.1093\/eurheartj\/ehx288","journal-title":"Eur Heart J"},{"key":"1120_CR92","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nrcardio.2017.102","volume":"14","author":"RA Kloner","year":"2017","unstructured":"Kloner RA, Brown DA, Csete M, Dai W, Downey JM, Gottlieb RA, Hale SL, Shi J (2017) New and revisited approaches to preserving the reperfused myocardium. Nat Rev Cardiol 14:679\u2013693. https:\/\/doi.org\/10.1038\/nrcardio.2017.102","journal-title":"Nat Rev Cardiol"},{"key":"1120_CR93","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1172\/JCI107898","volume":"54","author":"RA Kloner","year":"1974","unstructured":"Kloner RA, Ganote CE, Jennings RB (1974) The \u201cno-reflow\u201d phenomenon after temporary coronary occlusion in the dog. J Clin Invest 54:1496\u20131508. https:\/\/doi.org\/10.1172\/JCI107898","journal-title":"J Clin Invest"},{"key":"1120_CR94","first-page":"399","volume":"74","author":"RA Kloner","year":"1974","unstructured":"Kloner RA, Ganote CE, Whalen DA Jr, Jennings RB (1974) Effect of a transient period of ischemia on myocardial cells: II. Fine structure during the first few minutes of reflow. Am J Pathol 74:399","journal-title":"Am J Pathol"},{"issue":"3","key":"1120_CR95","doi-asserted-by":"publisher","first-page":"H550","DOI":"10.1152\/ajpheart.00183.2018","volume":"315","author":"RA Kloner","year":"2018","unstructured":"Kloner RA, King KS, Harrington MG (2018) No-reflow phenomenon in the heart and brain. Am J Physiol Heart Circ Physiol 315(3):H550\u2013H562. https:\/\/doi.org\/10.1152\/ajpheart.00183.2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1120_CR96","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.jacep.2022.12.008","volume":"9","author":"H K\u00f6nemann","year":"2023","unstructured":"K\u00f6nemann H, Ellermann C, Zeppenfeld K, Eckardt L (2023) Management of ventricular arrhythmias worldwide: comparison of the latest ESC, AHA\/ACC\/HRS, and CCS\/CHRS guidelines. JACC Clin Electrophysiol 9:715\u2013728. https:\/\/doi.org\/10.1016\/j.jacep.2022.12.008","journal-title":"JACC Clin Electrophysiol"},{"key":"1120_CR97","doi-asserted-by":"publisher","first-page":"H9","DOI":"10.1152\/ajpheart.1990.258.1.H9","volume":"258","author":"Y Koretsune","year":"1990","unstructured":"Koretsune Y, Marban E (1990) Mechanism of ischemic contracture in ferret hearts: relative roles of [Ca2+] i elevation and ATP depletion. Am J Physiol 258:H9\u2013H16. https:\/\/doi.org\/10.1152\/ajpheart.1990.258.1.H9","journal-title":"Am J Physiol"},{"key":"1120_CR98","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1146\/annurev.physiol.60.1.619","volume":"60","author":"G Kroemer","year":"1998","unstructured":"Kroemer G, Dallaporta B, Resche-Rigon M (1998) The mitochondrial death\/life regulator in apoptosis and necrosis. Annu Rev Physiol 60:619\u2013642. https:\/\/doi.org\/10.1146\/annurev.physiol.60.1.619","journal-title":"Annu Rev Physiol"},{"key":"1120_CR99","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1161\/01.res.19.1.57","volume":"19","author":"A Krug","year":"1966","unstructured":"Krug A, De Rochemont WDM, Korb G (1966) Blood supply of the myocardium after temporary coronary occlusion. Circ Res 19:57\u201362. https:\/\/doi.org\/10.1161\/01.res.19.1.57","journal-title":"Circ Res"},{"key":"1120_CR100","unstructured":"Lacerda L, Jacobs M, Opie L, Lecour S (2011) Ischaemic postconditioning confers protection via TNF-alpha: identifying the cellular origin of TNF-alpha. In AM J Res Crit Care Med, Amer Thoracic Soc. New York, pp 662\u2013662"},{"key":"1120_CR101","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.yjmcc.2003.09.016","volume":"35","author":"Y Ladilov","year":"2003","unstructured":"Ladilov Y, Efe \u00d6, Sch\u00e4fer C, Rother B, Kasseckert S, Abdallah Y, Meuter K, Schl\u00fcter KD, Piper HM (2003) Reoxygenation-induced rigor-type contracture. J Mol Cell Cardiol 35:1481\u20131490. https:\/\/doi.org\/10.1016\/j.yjmcc.2003.09.016","journal-title":"J Mol Cell Cardiol"},{"key":"1120_CR102","doi-asserted-by":"publisher","first-page":"H1531","DOI":"10.1152\/ajpheart.1995.268.4.H1531","volume":"268","author":"Y Ladilov","year":"1995","unstructured":"Ladilov Y, Siegmund B, Piper H (1995) Protection of reoxygenated cardiomyocytes against hypercontracture by inhibition of Na+\/H+ exchange. Am J Physiol 268:H1531\u2013H1539. https:\/\/doi.org\/10.1152\/ajpheart.1995.268.4.H1531","journal-title":"Am J Physiol"},{"key":"1120_CR103","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.yjmcc.2009.03.019","volume":"47","author":"S Lecour","year":"2009","unstructured":"Lecour S (2009) Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: does it go beyond the RISK pathway? J Mol Cell Cardiol 47:32\u201340. https:\/\/doi.org\/10.1016\/j.yjmcc.2009.03.019","journal-title":"J Mol Cell Cardiol"},{"key":"1120_CR104","first-page":"768","volume-title":"Circ","author":"S Lecour","year":"1999","unstructured":"Lecour S, Minners J, Rochette L, Opie L, Sack M (1999) Tumor necrosis factor alpha confers cardiac preconditioning: Possible role of mitochondrial K-ATP channel mediated event. Circ. Lippincott Williams & Wilkins, Philadelphia, pp 768\u2013768"},{"key":"1120_CR105","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1006\/jmcc.2002.1533","volume":"34","author":"S Lecour","year":"2002","unstructured":"Lecour S, Smith RM, Woodward B, Opie LH, Rochette L, Sack MN (2002) Identification of a novel role for sphingolipid signaling in TNF \u03b1 and ischemic preconditioning mediated cardioprotection. J Mol Cell Cardiol 34:509\u2013518. https:\/\/doi.org\/10.1006\/jmcc.2002.1533","journal-title":"J Mol Cell Cardiol"},{"key":"1120_CR106","first-page":"785","volume":"5","author":"J Lie","year":"1976","unstructured":"Lie J, Sun S (1976) Ultrastructure of ischemic contracture of the left ventricle (\u201cstone heart\u201d). Mayo Clin Proc 5:785\u2013793","journal-title":"Mayo Clin Proc"},{"key":"1120_CR107","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/BF02005340","volume":"77","author":"J Lipasti","year":"1982","unstructured":"Lipasti J, Nevalainen T, Alanen K (1982) The relationship between ischemic contracture and no-reflow phenomenon in isolated rat heart. Basic Res Cardiol 77:404\u2013410. https:\/\/doi.org\/10.1007\/BF02005340","journal-title":"Basic Res Cardiol"},{"key":"1120_CR108","doi-asserted-by":"publisher","first-page":"8237071","DOI":"10.1155\/2019\/8237071","volume":"2019","author":"J Liu","year":"2019","unstructured":"Liu J, Zhao X, Gong Y, Zhang J, Zang Y, Xia L (2019) Exploring impaired SERCA pump-caused alternation occurrence in Ischemia. Camput Math Methods Md 2019:8237071. https:\/\/doi.org\/10.1155\/2019\/8237071","journal-title":"Camput Math Methods Md"},{"key":"1120_CR109","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jacc.2021.10.034","volume":"79","author":"T Liu","year":"2022","unstructured":"Liu T, Howarth AG, Chen Y, Nair AR, Yang H-J, Ren D, Tang R, Sykes J, Kovacs MS, Dey D (2022) Intramyocardial hemorrhage and the \u201cWave Front\u201d of reperfusion injury compromising myocardial salvage. J Am Coll Cardiol 79:35\u201348. https:\/\/doi.org\/10.1016\/j.jacc.2021.10.034","journal-title":"J Am Coll Cardiol"},{"key":"1120_CR110","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bja.2022.08.040","volume":"130","author":"Z Luo","year":"2023","unstructured":"Luo Z, Hu X, Wu C, Chan J, Liu Z, Guo C, Zhu R, Zhang L, Zhang Y, Jin S (2023) Plasma exosomes generated by ischaemic preconditioning are cardioprotective in a rat heart failure model. Br J Anaesth 130:29\u201338. https:\/\/doi.org\/10.1016\/j.bja.2022.08.040","journal-title":"Br J Anaesth"},{"key":"1120_CR111","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/s0022-2828(84)80638-0","volume":"16","author":"AS Manning","year":"1984","unstructured":"Manning AS, Hearse DJ (1984) Reperfusion-induced arrhythmias: mechanisms and prevention. J Mol Cell Cardiol 16:497\u2013518. https:\/\/doi.org\/10.1016\/s0022-2828(84)80638-0","journal-title":"J Mol Cell Cardiol"},{"key":"1120_CR112","doi-asserted-by":"publisher","first-page":"2710","DOI":"10.1172\/JCI107090","volume":"51","author":"PR Maroko","year":"1972","unstructured":"Maroko PR, Libby P, Ginks WR, Bloor CM, Shell WE, Sobel BE, Ross J Jr (1972) Coronary artery reperfusion: I. Early effects on local myocardial function and the extent of myocardial necrosis. J Clin Invest 51:2710\u20132716. https:\/\/doi.org\/10.1172\/JCI107090","journal-title":"J Clin Invest"},{"key":"1120_CR113","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jacc.2022.10.020","volume":"81","author":"MS Maron","year":"2023","unstructured":"Maron MS, Masri A, Choudhury L, Olivotto I, Saberi S, Wang A, Garcia-Pavia P, Lakdawala NK, Nagueh SF, Rader F (2023) Phase 2 study of aficamten in patients with obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol 81:34\u201345. https:\/\/doi.org\/10.1016\/j.jacc.2022.10.020","journal-title":"J Am Coll Cardiol"},{"key":"1120_CR114","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.yjmcc.2013.12.008","volume":"67","author":"JJ Martindale","year":"2014","unstructured":"Martindale JJ, Metzger JM (2014) Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization. J Mol Cell Cardiol 67:26\u201337. https:\/\/doi.org\/10.1016\/j.yjmcc.2013.12.008","journal-title":"J Mol Cell Cardiol"},{"key":"1120_CR115","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1161\/01.cir.76.5.981","volume":"76","author":"M Matsuda","year":"1987","unstructured":"Matsuda M, Fujiwara H, Onodera T, Tanaka M, Wu D, Fujiwara T, Hamashima Y, Kawai C (1987) Quantitative analysis of infarct size, contraction band necrosis, and coagulation necrosis in human autopsied hearts with acute myocardial infarction after treatment with selective intracoronary thrombolysis. Circulation 76:981\u2013989. https:\/\/doi.org\/10.1161\/01.cir.76.5.981","journal-title":"Circulation"},{"key":"1120_CR116","doi-asserted-by":"publisher","first-page":"12355","DOI":"10.1073\/pnas.1934654100","volume":"100","author":"JR McMullen","year":"2003","unstructured":"McMullen JR, Shioi T, Zhang L, Tarnavski O, Sherwood MC, Kang PM, Izumo S (2003) Phosphoinositide 3-kinase (p110\u03b1) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci USA 100:12355\u201312360. https:\/\/doi.org\/10.1073\/pnas.1934654100","journal-title":"Proc Natl Acad Sci USA"},{"key":"1120_CR117","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aag2588","volume":"10","author":"JA Meier","year":"2017","unstructured":"Meier JA, Hyun M, Cantwell M, Raza A, Mertens C, Raje V, Sisler J, Tracy E, Torres-Odio S, Gispert S, Shaw PE (2017) Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production. Sci Signal 10:eaag2588. https:\/\/doi.org\/10.1126\/scisignal.aag2588","journal-title":"Sci Signal"},{"key":"1120_CR118","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1253\/circj.cj-09-0342","volume":"73","author":"T Minamino","year":"2009","unstructured":"Minamino T (2009) Gap junctions mediate the spread of ischemia-reperfusion injury. Circ J 73:1591\u20131592. https:\/\/doi.org\/10.1253\/circj.cj-09-0342","journal-title":"Circ J"},{"key":"1120_CR119","doi-asserted-by":"publisher","first-page":"H891","DOI":"10.1152\/ajpheart.00259.2019","volume":"317","author":"PK Mishra","year":"2019","unstructured":"Mishra PK, Adameova A, Hill JA, Baines CP, Kang PM, Downey JM, Narula J, Takahashi M, Abbate A, Piristine HC, Kar S (2019) Guidelines for evaluating myocardial cell death. Am J Physiol Heart Circ Physiol 317:H891\u2013H922. https:\/\/doi.org\/10.1152\/ajpheart.00259.2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1120_CR120","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1161\/01.res.71.3.605","volume":"71","author":"H Miyata","year":"1992","unstructured":"Miyata H, Lakatta EG, Stern MD, Silverman HS (1992) Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia. Circ Res 71:605\u2013613. https:\/\/doi.org\/10.1161\/01.res.71.3.605","journal-title":"Circ Res"},{"key":"1120_CR121","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","volume":"396","author":"CJ Murray","year":"2020","unstructured":"Murray CJ, Aravkin AY, Zheng P, Abbafati C, Abbas KM, Abbasi-Kangevari M (2020) Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396:1223\u20131249. https:\/\/doi.org\/10.1016\/S0140-6736(20)30752-2","journal-title":"Lancet"},{"key":"1120_CR122","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1139\/y90-029","volume":"68","author":"C Nichols","year":"1990","unstructured":"Nichols C, Lederer W (1990) The role of ATP in energy-deprivation contractures in unloaded rat ventricular myocytes. Can J Physiol Pharmacol 68:183\u2013194. https:\/\/doi.org\/10.1139\/y90-029","journal-title":"Can J Physiol Pharmacol"},{"key":"1120_CR123","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1161\/01.RES.0000117583.66950.43","volume":"94","author":"B O\u2019Rourke","year":"2004","unstructured":"O\u2019Rourke B (2004) Evidence for mitochondrial K+ channels and their role in cardioprotection. Circ Res 94:420\u2013432. https:\/\/doi.org\/10.1161\/01.RES.0000117583.66950.43","journal-title":"Circ Res"},{"key":"1120_CR124","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-012-0270-8","volume":"107","author":"MI Oerlemans","year":"2012","unstructured":"Oerlemans MI, Liu J, Arslan F, den Ouden K, van Middelaar BJ, Doevendans PA, Sluijter JP (2012) Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia\u2013reperfusion in vivo. Basic Res Cardiol 107:1\u201313. https:\/\/doi.org\/10.1007\/s00395-012-0270-8","journal-title":"Basic Res Cardiol"},{"key":"1120_CR125","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1161\/01.cir.80.4.1049","volume":"80","author":"L Opie","year":"1989","unstructured":"Opie L (1989) Reperfusion injury and its pharmacologic modification. Circulation 80:1049\u20131062. https:\/\/doi.org\/10.1161\/01.cir.80.4.1049","journal-title":"Circulation"},{"key":"1120_CR126","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1161\/01.res.87.6.460","volume":"87","author":"T Pain","year":"2000","unstructured":"Pain T, Yang XM, Critz SD, Yue Y, Nakano A, Liu GS, Heusch G, Cohen MV, Downey JM (2000) Opening of mitochondrial KATP channels triggers the preconditioned state by generating free radicals. Circ Res 87:460\u2013466. https:\/\/doi.org\/10.1161\/01.res.87.6.460","journal-title":"Circ Res"},{"key":"1120_CR127","doi-asserted-by":"publisher","first-page":"9062","DOI":"10.1038\/s41598-018-27429-7","volume":"8","author":"A Paolini","year":"2018","unstructured":"Paolini A, Omairi S, Mitchell R, Vaughan D, Matsakas A, Vaiyapuri S, Ricketts T, Rubinsztein DC, Patel K (2018) Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury. Sci Rep 8:9062. https:\/\/doi.org\/10.1038\/s41598-018-27429-7","journal-title":"Sci Rep"},{"key":"1120_CR128","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.ijcard.2009.07.013","volume":"146","author":"H Park","year":"2011","unstructured":"Park H, Otani H, Oishi C, Fujikawa M, Yamashita K, Okazaki T, Sato D, Ueyama T, Iwasaka J, Yamamoto Y (2011) Efficacy of intracoronary administration of a short-acting \u03b2-blocker landiolol during reperfusion in pigs. Int J Cardiol 146:347\u2013353. https:\/\/doi.org\/10.1016\/j.ijcard.2009.07.013","journal-title":"Int J Cardiol"},{"key":"1120_CR129","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1152\/japplphysiol.01235.2001","volume":"97","author":"KK Parker","year":"2004","unstructured":"Parker KK, Lavelle JA, Taylor LK, Wang Z, Hansen DE (2004) Stretch-induced ventricular arrhythmias during acute ischemia and reperfusion. J Appl Physiol 97:377\u2013383. https:\/\/doi.org\/10.1152\/japplphysiol.01235.2001","journal-title":"J Appl Physiol"},{"key":"1120_CR130","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1136\/hrt.2005.086934","volume":"92","author":"M Pasotti","year":"2006","unstructured":"Pasotti M, Prati F, Arbustini E (2006) The pathology of myocardial infarction in the pre-and post-interventional era. Heart 92:1552\u20131556. https:\/\/doi.org\/10.1136\/hrt.2005.086934","journal-title":"Heart"},{"key":"1120_CR131","doi-asserted-by":"publisher","DOI":"10.1161\/circ.120.suppl_18.S321","author":"AR Payne","year":"2009","unstructured":"Payne AR, Berry C, Kellman P, Anderson R, Chen MY, Watkins S, McPhaden AR, Schenke W, Wright V, Lederman RJ, Aletras AH (2009) T2-weighted MRI has high diagnostic accuracy for myocardial hemorrhage in myocardial infarction: a preclinical validation study in swine. Circ. https:\/\/doi.org\/10.1161\/circ.120.suppl_18.S321","journal-title":"Circ"},{"key":"1120_CR132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-021-00852-0","volume":"116","author":"L Pearce","year":"2021","unstructured":"Pearce L, Davidson SM, Yellon DM (2021) Does remote ischaemic conditioning reduce inflammation? A focus on innate immunity and cytokine response. Basic Res Cardiol 116:1\u201320. https:\/\/doi.org\/10.1007\/s00395-021-00852-0","journal-title":"Basic Res Cardiol"},{"key":"1120_CR133","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-024-01094-6","author":"L Pearce","year":"2024","unstructured":"Pearce L, Gal\u00e1n-Arriola C, Bell R, Carr R, Cunningham J, Davidson S, Ghosh A, Giesz S, Golforoush P, Gourine A (2024) Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop. Basic Res Cardiol. https:\/\/doi.org\/10.1007\/s00395-024-01094-6","journal-title":"Basic Res Cardiol"},{"key":"1120_CR134","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.freeradbiomed.2010.11.030","volume":"50","author":"G Petrosillo","year":"2011","unstructured":"Petrosillo G, Di Venosa N, Moro N, Colantuono G, Paradies V, Tiravanti E, Federici A, Ruggiero F, Paradies G (2011) In vivo hyperoxic preconditioning protects against rat-heart ischemia\/reperfusion injury by inhibiting mitochondrial permeability transition pore opening and cytochrome c release. Free Radic Biol Med 50:477\u2013483. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.11.030","journal-title":"Free Radic Biol Med"},{"key":"1120_CR135","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.cardiores.2003.12.012","volume":"61","author":"H Piper","year":"2004","unstructured":"Piper H, Abdallah Y, Sch\u00e4fer C (2004) The first minutes of reperfusion: a window of opportunity for cardioprotection. Cardiovasc Res 61:365\u2013371. https:\/\/doi.org\/10.1016\/j.cardiores.2003.12.012","journal-title":"Cardiovasc Res"},{"key":"1120_CR136","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/s0008-6363(98)00033-9","volume":"38","author":"H Piper","year":"1998","unstructured":"Piper H, Garc\u00f1a-Dorado D, Ovize M (1998) A fresh look at reperfusion injury. Cardiovasc Res 38:291\u2013300. https:\/\/doi.org\/10.1016\/s0008-6363(98)00033-9","journal-title":"Cardiovasc Res"},{"key":"1120_CR137","first-page":"115","volume":"4","author":"H Piper","year":"1992","unstructured":"Piper H, Siegmund B, Schl\u00fcter K (1992) Prevention of the oxygen paradox in the isolated cardiomyocyte and the whole heart. Am J Cardiovasc Pathol 4:115\u2013122","journal-title":"Am J Cardiovasc Pathol"},{"key":"1120_CR138","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.cardiores.2006.03.010","volume":"70","author":"HM Piper","year":"2006","unstructured":"Piper HM, Kasseckert S, Abdallah Y (2006) The sarcoplasmic reticulum as the primary target of reperfusion protection. Cardiovasc Res 70:170\u2013173. https:\/\/doi.org\/10.1016\/j.cardiores.2006.03.010","journal-title":"Cardiovasc Res"},{"key":"1120_CR139","doi-asserted-by":"publisher","first-page":"S644","DOI":"10.1016\/s0003-4975(02)04686-6","volume":"75","author":"HM Piper","year":"2003","unstructured":"Piper HM, Meuter K, Sch\u00e4fer C (2003) Cellular mechanisms of ischemia-reperfusion injury. Ann Thorac Surg 75:S644\u2013S648. https:\/\/doi.org\/10.1016\/s0003-4975(02)04686-6","journal-title":"Ann Thorac Surg"},{"key":"1120_CR140","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1161\/01.cir.96.2.659","volume":"96","author":"SV Pislaru","year":"1997","unstructured":"Pislaru SV, Barrios L, Stassen T, Jun L, Pislaru C, Van de Werf F (1997) Infarct size, myocardial hemorrhage, and recovery of function after mechanical versus pharmacological reperfusion: effects of lytic state and occlusion time. Circulation 96:659\u2013666. https:\/\/doi.org\/10.1161\/01.cir.96.2.659","journal-title":"Circulation"},{"key":"1120_CR141","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s00395-023-01002-4","volume":"118","author":"HA Prag","year":"2023","unstructured":"Prag HA, Murphy MP, Krieg T (2023) Preventing mitochondrial reverse electron transport as a strategy for cardioprotection. Basic Res Cardiol 118:34. https:\/\/doi.org\/10.1007\/s00395-023-01002-4","journal-title":"Basic Res Cardiol"},{"issue":"770","key":"1120_CR142","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abo4457","volume":"16","author":"JM Quiles","year":"2023","unstructured":"Quiles JM, Najor RH, Gonzalez E, Jeung M, Liang W, Burbach SM, Zumaya EA, Diao RY, Lampert MA, Gustafsson \u00c5B (2023) Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy. Sci Signal 16(770):eabo4457. https:\/\/doi.org\/10.1126\/scisignal.abo4457","journal-title":"Sci Signal"},{"key":"1120_CR143","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102884","volume":"57","author":"CJ Ramachandra","year":"2020","unstructured":"Ramachandra CJ, Hernandez-Resendiz S, Crespo-Avilan GE, Lin Y-H, Hausenloy DJ (2020) Mitochondria in acute myocardial infarction and cardioprotection. EBioMedicine 57:102884. https:\/\/doi.org\/10.1016\/j.ebiom.2020.102884","journal-title":"EBioMedicine"},{"key":"1120_CR144","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1161\/01.cir.56.5.794","volume":"56","author":"M Rasmussen","year":"1977","unstructured":"Rasmussen M, Reimer K, Kloner R, Jennings R (1977) Infarct size reduction by propranolol before and after coronary ligation in dogs. Circulation 56:794\u2013798. https:\/\/doi.org\/10.1161\/01.cir.56.5.794","journal-title":"Circulation"},{"key":"1120_CR145","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/s0046-8177(87)80031-x","volume":"18","author":"KA Reimer","year":"1987","unstructured":"Reimer KA, Ideker RE (1987) Myocardial ischemia and infarction: anatomic and biochemical substrates for ischemic cell death and ventricular arrhythmias. Hum Pathol 18:462\u2013475. https:\/\/doi.org\/10.1016\/s0046-8177(87)80031-x","journal-title":"Hum Pathol"},{"key":"1120_CR146","first-page":"633","volume":"40","author":"KA Reimer","year":"1979","unstructured":"Reimer KA, Jennings RB (1979) The\" wavefront phenomenon\" of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 40:633\u2013644","journal-title":"Lab Invest"},{"key":"1120_CR147","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1161\/01.cir.56.5.786","volume":"56","author":"KA Reimer","year":"1977","unstructured":"Reimer KA, Lowe JE, Rasmussen MM, Jennings RB (1977) The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation 56:786\u2013794. https:\/\/doi.org\/10.1161\/01.cir.56.5.786","journal-title":"Circulation"},{"key":"1120_CR148","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s10741-007-9039-9","volume":"12","author":"A Rodr\u00edguez-Sinovas","year":"2007","unstructured":"Rodr\u00edguez-Sinovas A, Abdallah Y, Piper HM, Garcia-Dorado D (2007) Reperfusion injury as a therapeutic challenge in patients with acute myocardial infarction. Heart Fail Rev 12:207\u2013216. https:\/\/doi.org\/10.1007\/s10741-007-9039-9","journal-title":"Heart Fail Rev"},{"key":"1120_CR149","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1016\/j.jacc.2016.03.522","volume":"67","author":"V Roolvink","year":"2016","unstructured":"Roolvink V, Ib\u00e1\u00f1ez B, Ottervanger JP, Pizarro G, Van Royen N, Mateos A, Dambrink J-HE, Escalera N, Lipsic E, Albarran A (2016) Early intravenous beta-blockers in patients with ST-segment elevation myocardial infarction before primary percutaneous coronary intervention. J Am Coll Cardiol 67:2705\u20132715. https:\/\/doi.org\/10.1016\/j.jacc.2016.03.522","journal-title":"J Am Coll Cardiol"},{"key":"1120_CR150","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/jcmm.13394","volume":"22","author":"X Rossello","year":"2018","unstructured":"Rossello X, Riquelme JA, Davidson SM, Yellon DM (2018) Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion. J Cell Mol Med 22:926\u2013935. https:\/\/doi.org\/10.1111\/jcmm.13394","journal-title":"J Cell Mol Med"},{"key":"1120_CR151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-017-0657-7","volume":"112","author":"X Rossello","year":"2017","unstructured":"Rossello X, Riquelme JA, He Z, Taferner S, Vanhaesebroeck B, Davidson SM, Yellon DM (2017) The role of PI3K\u03b1 isoform in cardioprotection. Basic Res Cardiol 112:1\u201317. https:\/\/doi.org\/10.1007\/s00395-017-0657-7","journal-title":"Basic Res Cardiol"},{"key":"1120_CR152","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","volume":"76","author":"GA Roth","year":"2020","unstructured":"Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP, Bonny A (2020) Global burden of cardiovascular diseases and risk factors, 1990\u20132019: update from the GBD 2019 study. J Am Coll Cardiol 76:2982\u20133021. https:\/\/doi.org\/10.1016\/j.jacc.2020.11.010","journal-title":"J Am Coll Cardiol"},{"key":"1120_CR153","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1007\/s00395-007-0675-y","volume":"102","author":"M Ruiz-Meana","year":"2007","unstructured":"Ruiz-Meana M, Abell\u00e1n A, Mir\u00f3-Casas E, Garcia-Dorado D (2007) Opening of mitochondrial permeability transition pore induces hypercontracture in Ca2+ overloaded cardiac myocytes. Basic Res Cardiol 102:542\u2013552. https:\/\/doi.org\/10.1007\/s00395-007-0675-y","journal-title":"Basic Res Cardiol"},{"key":"1120_CR154","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1161\/01.res.85.3.280","volume":"85","author":"M Ruiz-Meana","year":"1999","unstructured":"Ruiz-Meana M, Garcia-Dorado D, Hofstaetter B, Piper HM, Soler-Soler J (1999) Propagation of cardiomyocyte hypercontracture by passage of Na+ through gap junctions. Circ Res 85:280\u2013287. https:\/\/doi.org\/10.1161\/01.res.85.3.280","journal-title":"Circ Res"},{"key":"1120_CR155","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/s0008-6363(01)00282-6","volume":"51","author":"C Sch\u00e4fer","year":"2001","unstructured":"Sch\u00e4fer C, Ladilov Y, Inserte J, Sch\u00e4fer M, Haffner S, Garcia-Dorado D, Piper H (2001) Role of the reverse mode of the Na+\/Ca2+ exchanger in reoxygenation-induced cardiomyocyte injury. Cardiovasc Res 51:241\u2013250. https:\/\/doi.org\/10.1016\/s0008-6363(01)00282-6","journal-title":"Cardiovasc Res"},{"key":"1120_CR156","doi-asserted-by":"publisher","first-page":"H428","DOI":"10.1152\/ajpheart.1996.271.2.H428","volume":"271","author":"K Schluter","year":"1996","unstructured":"Schluter K, Jakob G, Ruiz-Meana M, Garcia-Dorado D, Piper H (1996) Protection of reoxygenated cardiomyocytes against osmotic fragility by nitric oxide donors. Am J Physiol Heart Circ Physiol 271:H428\u2013H434. https:\/\/doi.org\/10.1152\/ajpheart.1996.271.2.H428","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1120_CR157","doi-asserted-by":"publisher","first-page":"H416","DOI":"10.1152\/ajpheart.1991.261.2.H416","volume":"261","author":"K Schluter","year":"1991","unstructured":"Schluter K, Schwartz P, Siegmund B, Piper H (1991) Prevention of the oxygen paradox in hypoxic-reoxygenated hearts. Am J Physiol 261:H416\u2013H423. https:\/\/doi.org\/10.1152\/ajpheart.1991.261.2.H416","journal-title":"Am J Physiol"},{"key":"1120_CR158","first-page":"417","volume":"67","author":"AC Shen","year":"1972","unstructured":"Shen AC, Jennings RB (1972) Myocardial calcium and magnesium in acute ischemic injury. Am J Pathol 67:417","journal-title":"Am J Pathol"},{"key":"1120_CR159","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/BF01906955","volume":"83","author":"AJ Sheppard","year":"1988","unstructured":"Sheppard AJ, Gavin J (1988) The transmural progression of the no-reflow phenomenon in globally ischemic hearts. Basic Res Cardiol 83:611\u2013617. https:\/\/doi.org\/10.1007\/BF01906955","journal-title":"Basic Res Cardiol"},{"key":"1120_CR160","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1253\/circj.cj-09-0079","volume":"73","author":"K Shintani-Ishida","year":"2009","unstructured":"Shintani-Ishida K, Unuma K, Yoshida K-i (2009) Ischemia enhances translocation of connexin43 and gap junction intercellular communication, thereby propagating contraction band necrosis after reperfusion. Circ J 73:1661\u20131668. https:\/\/doi.org\/10.1253\/circj.cj-09-0079","journal-title":"Circ J"},{"key":"1120_CR161","doi-asserted-by":"publisher","first-page":"4372","DOI":"10.1161\/01.cir.96.12.4372","volume":"96","author":"B Siegmund","year":"1997","unstructured":"Siegmund B, Schlack W, Ladilov YV, Balser C, Piper HM (1997) Halothane protects cardiomyocytes against reoxygenation-induced hypercontracture. Circulation 96:4372\u20134379. https:\/\/doi.org\/10.1161\/01.cir.96.12.4372","journal-title":"Circulation"},{"key":"1120_CR162","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2021.102004","volume":"54","author":"G Simon","year":"2022","unstructured":"Simon G, T\u00f3th D, Heckmann V, Kuzma M, Mayer M (2022) Lethal case of myocardial ischemia following overdose of the synthetic cannabinoid ADB-FUBINACA. Leg Med 54:102004. https:\/\/doi.org\/10.1016\/j.legalmed.2021.102004","journal-title":"Leg Med"},{"key":"1120_CR163","doi-asserted-by":"publisher","first-page":"H159","DOI":"10.1152\/ajpheart.00152.2018","volume":"315","author":"A Skyschally","year":"2018","unstructured":"Skyschally A, Kleinbongard P, Lieder H, Gedik N, Stoian L, Amanakis G, Elbers E, Heusch G (2018) Humoral transfer and intramyocardial signal transduction of protection by remote ischemic perconditioning in pigs, rats, and mice. Am J Physiol Heart Circ Physiol 315:H159\u2013H172. https:\/\/doi.org\/10.1152\/ajpheart.00152.2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1120_CR164","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1161\/CIRCRESAHA.108.186429","volume":"104","author":"A Skyschally","year":"2009","unstructured":"Skyschally A, van Caster P, Boengler K, Gres P, Musiolik J, Schilawa D, Schulz R, Heusch G (2009) Ischemic postconditioning in pigs: no causal role for RISK activation. Circ Res 104:15\u201318. https:\/\/doi.org\/10.1161\/CIRCRESAHA.108.186429","journal-title":"Circ Res"},{"key":"1120_CR165","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/BF00191349","volume":"426","author":"J Solares","year":"1995","unstructured":"Solares J, Garcia-Dorado D, Oliveras J, Gonz\u00e1les M, Ruiz-Meana M, Barrabes J, Gonzalez-Bravo C, Soler-Soler J (1995) Contraction band necrosis at the lateral borders of the area at risk in reperfused infarcts: Observations in a pig model of in situ coronary occlusion. Virchows Arch 426:393\u2013399. https:\/\/doi.org\/10.1007\/BF00191349","journal-title":"Virchows Arch"},{"key":"1120_CR166","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00763-7","author":"JA Spertus","year":"2021","unstructured":"Spertus JA, Fine JT, Elliott P, Ho CY, Olivotto I, Saberi S, Li W, Dolan C, Reaney M, Sehnert AJ (2021) Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. https:\/\/doi.org\/10.1016\/S0140-6736(21)00763-7","journal-title":"Lancet"},{"key":"1120_CR167","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0379-0738(90)90232-n","volume":"45","author":"E St\u00e5hl","year":"1990","unstructured":"St\u00e5hl E (1990) Screening of myocardial contraction bands: a comparison between two histological staining methods. Forensic Sci Int 45:151\u2013157. https:\/\/doi.org\/10.1016\/0379-0738(90)90232-n","journal-title":"Forensic Sci Int"},{"key":"1120_CR168","doi-asserted-by":"publisher","first-page":"H156","DOI":"10.1152\/ajpheart.00076.2019","volume":"317","author":"A Stamenkovic","year":"2019","unstructured":"Stamenkovic A, Pierce GN, Ravandi A (2019) Phospholipid oxidation products in ferroptotic myocardial cell death. Am J Physiol 317:H156\u2013H163. https:\/\/doi.org\/10.1152\/ajpheart.00076.2019","journal-title":"Am J Physiol"},{"key":"1120_CR169","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1001\/jama.293.9.1063","volume":"293","author":"GW Stone","year":"2005","unstructured":"Stone GW, Webb J, Cox DA, Brodie BR, Qureshi M, Kalynych A, Turco M, Schultheiss HP, Dulas D, Rutherford BD (2005) Distal microcirculatory protection during percutaneous coronary intervention in acute ST-segment elevation myocardial infarction: a randomized controlled trial. Jama 293:1063\u20131072. https:\/\/doi.org\/10.1001\/jama.293.9.1063","journal-title":"Jama"},{"key":"1120_CR170","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8726564","volume":"2022","author":"X Su","year":"2022","unstructured":"Su X, Zhou M, Li Y, An N, Yang F, Zhang G, Xu L, Chen H, Wu H, Xing Y (2022) Mitochondrial damage in myocardial ischemia\/reperfusion injury and application of natural plant products. Oxid Med Cell Longev 2022:8726564. https:\/\/doi.org\/10.1155\/2022\/8726564","journal-title":"Oxid Med Cell Longev"},{"key":"1120_CR171","doi-asserted-by":"publisher","first-page":"29610","DOI":"10.1074\/jbc.M111.226209","volume":"286","author":"K Szczepanek","year":"2011","unstructured":"Szczepanek K, Chen Q, Derecka M, Salloum FN, Zhang Q, Szelag M, Cichy J, Kukreja RC, Dulak J, Lesnefsky EJ, Larner AC (2011) Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species. J Biol Chem 286:29610\u201329620. https:\/\/doi.org\/10.1074\/jbc.M111.226209","journal-title":"J Biol Chem"},{"key":"1120_CR172","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-015-0509-2","volume":"110","author":"K Szczepanek","year":"2015","unstructured":"Szczepanek K, Xu A, Hu Y, Thompson J, He J, Larner AC, Salloum FN, Chen Q, Lesnefsky EJ (2015) Cardioprotective function of mitochondrial-targeted and transcriptionally inactive STAT3 against ischemia and reperfusion injury. Basic Res Cardiol 110:1\u201310. https:\/\/doi.org\/10.1007\/s00395-015-0509-2","journal-title":"Basic Res Cardiol"},{"key":"1120_CR173","doi-asserted-by":"publisher","first-page":"H876","DOI":"10.1152\/ajpheart.1996.271.3.H876","volume":"271","author":"M Tani","year":"1996","unstructured":"Tani M, Asakura Y, Hasegawa H, Shinmura K, Ebihara Y, Nakamura Y (1996) Effect of preconditioning on ryanodine-sensitive Ca2+ release from sarcoplasmic reticulum of rat heart. Am J Physiol 271:H876\u2013H881. https:\/\/doi.org\/10.1152\/ajpheart.1996.271.3.H876","journal-title":"Am J Physiol"},{"key":"1120_CR174","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1161\/01.res.65.4.1045","volume":"65","author":"M Tani","year":"1989","unstructured":"Tani M, Neely JR (1989) Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange. Circ Res 65:1045\u20131056. https:\/\/doi.org\/10.1161\/01.res.65.4.1045","journal-title":"Circ Res"},{"key":"1120_CR175","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.jacc.2023.06.025","volume":"82","author":"PG Thrane","year":"2023","unstructured":"Thrane PG, Olesen KKW, Thim T, Gyldenkerne C, Mortensen MB, Kristensen SD, Maeng M (2023) Mortality trends after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. J Am Coll Cardiol 82:999\u20131010. https:\/\/doi.org\/10.1016\/j.jacc.2023.06.025","journal-title":"J Am Coll Cardiol"},{"key":"1120_CR176","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1093\/eurheartj\/ehz859","volume":"41","author":"A Timmis","year":"2020","unstructured":"Timmis A, Townsend N, Gale CP, Torbica A, Lettino M, Petersen SE, Mossialos EA, Maggioni AP, Kazakiewicz D, May HT (2020) European Society of Cardiology: cardiovascular disease statistics 2019. Eur Heart J 41:12\u201385. https:\/\/doi.org\/10.1093\/eurheartj\/ehz859","journal-title":"Eur Heart J"},{"key":"1120_CR177","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41569-023-00946-3","volume":"21","author":"S Toldo","year":"2024","unstructured":"Toldo S, Abbate A (2024) The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases. Nat Rev Cardiol 21:219\u2013237. https:\/\/doi.org\/10.1038\/s41569-023-00946-3","journal-title":"Nat Rev Cardiol"},{"key":"1120_CR178","doi-asserted-by":"publisher","unstructured":"Tribulova N, Knezl V, Bacova BS, Benova T, Viczenczova C, Gon\u00e7alvesova E, Slezak J (2016) Disordered myocardial Ca2+ homeostasis results in substructural alterations that may promote occurrence of malignant arrhythmias. Physiol Res 65:S139\u2013148 https:\/\/doi.org\/10.33549\/physiolres.933388","DOI":"10.33549\/physiolres.933388"},{"key":"1120_CR179","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12231","volume":"2","author":"HE Turrell","year":"2014","unstructured":"Turrell HE, Thaitirarot C, Crumbie H, Rodrigo G (2014) Remote ischemic preconditioning of cardiomyocytes inhibits the mitochondrial permeability transition pore independently of reduced calcium-loading or sarcKATP channel activation. Physiol Rep 2:e12231. https:\/\/doi.org\/10.14814\/phy2.12231","journal-title":"Physiol Rep"},{"issue":"5","key":"1120_CR180","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1161\/01.res.74.5.920","volume":"74","author":"R Ventura-Clapier","year":"1994","unstructured":"Ventura-Clapier R, Veksler V (1994) Myocardial ischemic contracture. Metabolites affect rigor tension development and stiffness. Circ Res 74(5):920\u2013929. https:\/\/doi.org\/10.1161\/01.res.74.5.920","journal-title":"Circ Res"},{"key":"1120_CR181","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.ejcts.2009.02.014","volume":"35","author":"V Venugopal","year":"2009","unstructured":"Venugopal V, Ludman A, Yellon DM, Hausenloy DJ (2009) \u2018Conditioning\u2019the heart during surgery. Eur Cardio-thorac Surg 35:977\u2013987. https:\/\/doi.org\/10.1016\/j.ejcts.2009.02.014","journal-title":"Eur Cardio-thorac Surg"},{"key":"1120_CR182","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1016\/s0140-6736(96)90803-x","volume":"347","author":"R Virmani","year":"1996","unstructured":"Virmani R, Farb A (1996) Contraction-band necrosis: new use for an old friend. The Lancet 347:1710\u20131711. https:\/\/doi.org\/10.1016\/s0140-6736(96)90803-x","journal-title":"The Lancet"},{"key":"1120_CR183","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/s0735-1097(87)80234-6","volume":"9","author":"BF Waller","year":"1987","unstructured":"Waller BF, Rothbaum DA, Pinkerton CA, Cowley MJ, Linnemeier TJ, Orr C, Irons M, Helmuth RA, Wills ER, Aust C (1987) Status of the myocardium and infarct-related coronary artery in 19 necropsy patients with acute recanalization using pharmacologic (streptokinase, r-tissue plasminogen activator), mechanical (percutaneous transluminal coronary angioplasty) or combined types of reperfusion therapy. J Am Coll Cardiol 9:785\u2013801. https:\/\/doi.org\/10.1016\/s0735-1097(87)80234-6","journal-title":"J Am Coll Cardiol"},{"key":"1120_CR184","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/s0014-2999(96)00901-6","volume":"320","author":"J Wang","year":"1997","unstructured":"Wang J, Drake L, Sajjadi F, Firestein GS, Mullane KM, Bullough DA (1997) Dual activation of adenosine A1 and A3 receptors mediates preconditioning of isolated cardiac myocytes. Eur J Pharmacol 320:241\u2013248. https:\/\/doi.org\/10.1016\/s0014-2999(96)00901-6","journal-title":"Eur J Pharmacol"},{"key":"1120_CR185","doi-asserted-by":"publisher","first-page":"H2321","DOI":"10.1152\/ajpheart.2001.280.5.H2321","volume":"280","author":"L Wang","year":"2001","unstructured":"Wang L, Cherednichenko G, Hernandez L, Halow J, Camacho SA, Figueredo V, Schaefer S (2001) Preconditioning limits mitochondrial Ca2+ during ischemia in rat hearts: role of KATP channels. Am J Physiol 280:H2321\u2013H2328. https:\/\/doi.org\/10.1152\/ajpheart.2001.280.5.H2321","journal-title":"Am J Physiol"},{"key":"1120_CR186","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008024","volume":"7","author":"X Wang","year":"2018","unstructured":"Wang X, Guo Z, Ding Z, Mehta JL (2018) Inflammation, autophagy, and apoptosis after myocardial infarction. J Am Heart Assoc 7:e008024. https:\/\/doi.org\/10.1161\/JAHA.117.008024","journal-title":"J Am Heart Assoc"},{"key":"1120_CR187","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1161\/01.res.0000094746.24774.dc","volume":"93","author":"Y Wang","year":"2003","unstructured":"Wang Y, Meyer JW, Ashraf M, Shull GE (2003) Mice with a null mutation in the NHE1 Na+-H+ exchanger are resistant to cardiac ischemia-reperfusion injury. Circ Res 93:776\u2013782. https:\/\/doi.org\/10.1161\/01.res.0000094746.24774.dc","journal-title":"Circ Res"},{"key":"1120_CR188","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1126\/science.1164551","volume":"323","author":"J Wegrzyn","year":"2009","unstructured":"Wegrzyn J, Potla R, Chwae Y-J, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A (2009) Function of mitochondrial Stat3 in cellular respiration. Science 323:793\u2013797. https:\/\/doi.org\/10.1126\/science.1164551","journal-title":"Science"},{"key":"1120_CR189","unstructured":"Whalen Jr DA, Hamilton DG, Ganote CE, Jennings RB (1974) Effect of a transient period of ischemia on myocardial cells: I. Effects on cell volume regulation. Am J Pathol 74:381"},{"key":"1120_CR190","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/BF02301880","volume":"6","author":"D-J Wu","year":"1990","unstructured":"Wu D-J, Fujiwara H, Matsuda M, Ishida M, Kawamura A, Takemura G, Kida M, Uegaito T, Fujiwara T, Kawai C (1990) Clinicopathological study of myocardial infarction with normal or nearly normal extracardiac coronary arteries. Quantitative analysis of contraction band necrosis, coagulation necrosis, hemorrhage, and infarct size. Heart Vessels 6:55\u201362. https:\/\/doi.org\/10.1007\/BF02301880","journal-title":"Heart Vessels"},{"key":"1120_CR191","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s00395-023-00992-5","volume":"118","author":"DM Yellon","year":"2023","unstructured":"Yellon DM, Beikoghli Kalkhoran S, Davidson SM (2023) The RISK pathway leading to mitochondria and cardioprotection: how everything started. Bas Res Cardiol 118:22. https:\/\/doi.org\/10.1007\/s00395-023-00992-5","journal-title":"Bas Res Cardiol"},{"key":"1120_CR192","doi-asserted-by":"publisher","first-page":"H2383","DOI":"10.1152\/ajpheart.1994.267.6.H2383","volume":"267","author":"K Ytrehus","year":"1994","unstructured":"Ytrehus K, Liu Y, Tsuchida A, Miura T, Liu GS, Yang X, Herbert D, Cohen MV, Downey JM (1994) Rat and rabbit heart infarction: effects of anesthesia, perfusate, risk zone, and method of infarct sizing. Am J Physiol 267:H2383\u2013H2390. https:\/\/doi.org\/10.1152\/ajpheart.1994.267.6.H2383","journal-title":"Am J Physiol"},{"key":"1120_CR193","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41420-021-00579-w","volume":"7","author":"Y Yu","year":"2021","unstructured":"Yu Y, Yan Y, Niu F, Wang Y, Chen X, Su G, Liu Y, Zhao X, Qian L, Liu P, Xiong Y (2021) Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discov 7:193. https:\/\/doi.org\/10.1038\/s41420-021-00579-w","journal-title":"Cell Death Discov"},{"key":"1120_CR194","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-024-07663-0","author":"NLM Yusof","year":"2025","unstructured":"Yusof NLM, Yellon DM, Davidson SM (2025) Novel selective cardiac myosin-targeted inhibitors alleviate myocardial ischaemia-reperfusion injury. Cardiovasc Drugs Ther. https:\/\/doi.org\/10.1007\/s10557-024-07663-0","journal-title":"Cardiovasc Drugs Ther"},{"key":"1120_CR195","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.yjmcc.2018.01.018","volume":"116","author":"H Zhu","year":"2018","unstructured":"Zhu H, Sun A (2018) Programmed necrosis in heart disease: molecular mechanisms and clinical implications. J Mol Cell Cardiol 116:125\u2013134. https:\/\/doi.org\/10.1016\/j.yjmcc.2018.01.018","journal-title":"J Mol Cell Cardiol"},{"key":"1120_CR196","unstructured":"Zipes D (1975) Electrophysiological mechanisms involved in ventricular fibrillation. Circ 52:III120\u2013III130"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-025-01120-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-025-01120-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-025-01120-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T18:58:54Z","timestamp":1757185134000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-025-01120-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":196,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["1120"],"URL":"https:\/\/doi.org\/10.1007\/s00395-025-01120-1","relation":{},"ISSN":["1435-1803"],"issn-type":[{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"17 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}