{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:57:53Z","timestamp":1792155473825,"version":"4.4.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["81Z2700204"],"award-info":[{"award-number":["81Z2700204"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["81Z2700201"],"award-info":[{"award-number":["81Z2700201"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["81Z0700206"],"award-info":[{"award-number":["81Z0700206"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DAAD"},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"crossref","award":["20CVD01"],"award-info":[{"award-number":["20CVD01"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"crossref","award":["20CVD01"],"award-info":[{"award-number":["20CVD01"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Universit\u00e4tsklinikum Schleswig-Holstein - Campus Kiel"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The transition from cardiac hypertrophy to heart failure is characterized by metabolic changes like downregulation of fatty acid metabolism in favor of increased glucose utilization. Carnitine palmitoyltransferase 1B (CPT1B) catalyzes the rate-limiting step of the carnitine shuttle and is an essential enzyme for fatty acid oxidation. Down-regulation of CPT1B activity has been associated with heart failure in patients and various experimental models, indicating an important role in metabolic remodeling. Therefore, we aimed to investigate whether CPT1B overexpression could play a therapeutic role in heart failure. Gene transfer of CPT1B using adeno-associated virus (AAV) vectors into neonatal rat cardiomyocytes significantly attenuated phenylephrine-induced hypertrophy and resulted in decreased generation of mitochondrial reactive oxygen species. In mice subjected to transverse aortic constriction, AAV-mediated cardiac overexpression of CPT1B attenuated cardiomyocyte hypertrophy, cardiac fibrosis, and systolic dysfunction in vivo. Upregulation of CPT1B expression might therefore represent a promising approach to treat or prevent heart failure.<\/jats:p>","DOI":"10.1007\/s00395-025-01123-y","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T18:31:26Z","timestamp":1752258686000},"page":"975-989","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["AAV-mediated overexpression of CPT1B protects from cardiac hypertrophy and heart failure in a murine pressure overload model"],"prefix":"10.1007","volume":"120","author":[{"given":"Anca","family":"Kliesow Remes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Ruf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinatin","family":"Zurashvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Meyer-Jens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic M.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Matzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Michalewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Kilian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithviraj Manohar Vijaya","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christin","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Eden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann-Josef","family":"Gr\u00f6ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleopatra","family":"Rapti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jungmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Milting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Carrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derk","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-2638","authenticated-orcid":false,"given":"Oliver J.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"1123_CR1","doi-asserted-by":"publisher","first-page":"8716","DOI":"10.1074\/jbc.M509890200","volume":"281","author":"AS Augustus","year":"2006","unstructured":"Augustus AS, Buchanan J, Park TS, Hirata K, Noh HL, Sun J, Homma S, D\u2019Armiento J, Abel ED, Goldberg IJ (2006) Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J Biol Chem 281:8716\u20138723. https:\/\/doi.org\/10.1074\/jbc.M509890200","journal-title":"J Biol Chem"},{"issue":"3","key":"1123_CR2","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1113\/expphysiol.2007.040659","volume":"93","author":"T Banyasz","year":"2008","unstructured":"Banyasz T, Lozinskiy I, Payne CE, Edelmann S, Norton B, Chen B, Chen-Izu Y, Izu LT, Balke CW (2008) Transformation of adult rat cardiac myocytes in primary culture. Exp Physiol 93(3):370\u2013382. https:\/\/doi.org\/10.1113\/expphysiol.2007.040659","journal-title":"Exp Physiol"},{"issue":"5","key":"1123_CR3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1136\/hrt.65.5.245","volume":"65","author":"JJF Belch","year":"1991","unstructured":"Belch JJF, Bridges AB, Scott N, Chopra M (1991) Oxygen free radicals and congestive heart failure. Heart 65(5):245\u2013248. https:\/\/doi.org\/10.1136\/hrt.65.5.245","journal-title":"Heart"},{"key":"1123_CR4","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.jacbts.2020.05.014","volume":"5","author":"CA Blair","year":"2020","unstructured":"Blair CA, Brundage EA, Thompson KL, Stromberg A, Guglin M, Biesiadecki BJ, Campbell KS (2020) Heart failure in humans reduces contractile force in myocardium from both ventricles. JACC Basic Transl Sci 5:786\u2013798. https:\/\/doi.org\/10.1016\/j.jacbts.2020.05.014","journal-title":"JACC Basic Transl Sci"},{"key":"1123_CR5","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1194\/jlr.M200294-JLR200","volume":"44","author":"A Cabrero","year":"2003","unstructured":"Cabrero A, Merlos M, Laguna JC, Carrera MV (2003) Down-regulation of acyl-CoA oxidase gene expression and increased NF-\u03baB activity in etomoxir-induced cardiac hypertrophy. J Lipid Res 44:388\u2013398. https:\/\/doi.org\/10.1194\/jlr.M200294-JLR200","journal-title":"J Lipid Res"},{"key":"1123_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101849","volume":"3","author":"J Chen","year":"2022","unstructured":"Chen J, Yue F, Kuang S (2022) Labeling and analyzing lipid droplets in mouse muscle stem cells. STAR Protoc 3:101849. https:\/\/doi.org\/10.1016\/j.xpro.2022.101849","journal-title":"STAR Protoc"},{"key":"1123_CR7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s00395-023-01018-w","volume":"118","author":"S Chen","year":"2023","unstructured":"Chen S, Zou Y, Song C, Cao K, Cai K, Wu Y, Zhang Z, Geng D, Sun W, Ouyang N, Zhang N, Li Z, Sun G, Zhang Y, Sun Y, Zhang Y (2023) The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches. Basic Res Cardiol 118:48. https:\/\/doi.org\/10.1007\/s00395-023-01018-w","journal-title":"Basic Res Cardiol"},{"key":"1123_CR8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/s0735-1097(02)01967-8","volume":"40","author":"VG Davila-Roman","year":"2002","unstructured":"Davila-Roman VG, Vedala G, Herrero P, de las Fuentes L, Rogers JG, Kelly DP, Gropler RJ (2002) Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J Am Coll Cardiol 40:271\u2013277. https:\/\/doi.org\/10.1016\/s0735-1097(02)01967-8","journal-title":"J Am Coll Cardiol"},{"key":"1123_CR9","doi-asserted-by":"publisher","first-page":"5440","DOI":"10.1080\/21655979.2021.1967032","volume":"12","author":"Y Ding","year":"2021","unstructured":"Ding Y, Zhang H, Liu Z, Li Q, Guo Y, Chen Y, Chang Y, Cui H (2021) Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Abeta(25\u201335). Bioengineered 12:5440\u20135449. https:\/\/doi.org\/10.1080\/21655979.2021.1967032","journal-title":"Bioengineered"},{"key":"1123_CR10","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1161\/circresaha.113.300376","volume":"113","author":"T Doenst","year":"2013","unstructured":"Doenst T, Nguyen TD, Abel ED (2013) Cardiac metabolism in heart failure: Implications beyond atp production. Circ Res 113:709\u2013724. https:\/\/doi.org\/10.1161\/circresaha.113.300376","journal-title":"Circ Res"},{"key":"1123_CR11","doi-asserted-by":"crossref","unstructured":"Fillmore N, Mori J, Lopaschuk GD (2014) Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy. In:Br J Pharmacol, p 2080\u20132090","DOI":"10.1111\/bph.12475"},{"key":"1123_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/cells13110931","author":"AE Giovou","year":"2024","unstructured":"Giovou AE, Gladka MM, Christoffels VM (2024) The impact of natriuretic peptides on heart development, homeostasis, and disease. Cells. https:\/\/doi.org\/10.3390\/cells13110931","journal-title":"Cells"},{"key":"1123_CR13","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1111\/dom.12248","volume":"16","author":"KR Haynie","year":"2014","unstructured":"Haynie KR, Vandanmagsar B, Wicks SE, Zhang J, Mynatt RL (2014) Inhibition of carnitine palymitoyltransferase1b induces cardiac hypertrophy and mortality in mice. Diabetes Obes Metab 16:757\u2013760. https:\/\/doi.org\/10.1111\/dom.12248","journal-title":"Diabetes Obes Metab"},{"key":"1123_CR14","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1161\/circulationaha.111.075978","volume":"126","author":"L He","year":"2012","unstructured":"He L, Kim T, Long Q, Liu J, Wang P, Zhou Y, Ding Y, Prasain J, Wood PA, Yang Q (2012) Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity. Circulation 126:1705\u20131716. https:\/\/doi.org\/10.1161\/circulationaha.111.075978","journal-title":"Circulation"},{"key":"1123_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00395-023-01019-9","volume":"118","author":"S Hernandez-Resendiz","year":"2023","unstructured":"Hernandez-Resendiz S, Prakash A, Loo SJ, Semenzato M, Chinda K, Crespo-Avilan GE, Dam LC, Lu S, Scorrano L, Hausenloy DJ (2023) Targeting mitochondrial shape: at the heart of cardioprotection. Basic Res Cardiol 118:49. https:\/\/doi.org\/10.1007\/s00395-023-01019-9","journal-title":"Basic Res Cardiol"},{"key":"1123_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-022-00909-8","volume":"117","author":"G Heusch","year":"2022","unstructured":"Heusch G (2022) Coronary blood flow in heart failure: cause, consequence and bystander. Basic Res Cardiol 117:1. https:\/\/doi.org\/10.1007\/s00395-022-00909-8","journal-title":"Basic Res Cardiol"},{"key":"1123_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102894","volume":"67","author":"G Heusch","year":"2023","unstructured":"Heusch G, Andreadou I, Bell R, Bertero E, Botker HE, Davidson SM, Downey J, Eaton P, Ferdinandy P, Gersh BJ, Giacca M, Hausenloy DJ, Ibanez B, Krieg T, Maack C, Schulz R, Sellke F, Shah AM, Thiele H, Yellon DM, Di Lisa F (2023) Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection. Redox Biol 67:102894. https:\/\/doi.org\/10.1016\/j.redox.2023.102894","journal-title":"Redox Biol"},{"issue":"3","key":"1123_CR18","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ymgme.2007.10.006","volume":"93","author":"S Ji","year":"2008","unstructured":"Ji S, You Y, Kerner J, Hoppel CL, Schoeb TR, Chick WSH, Hamm DA, Sharer JD, Wood PA (2008) Homozygous carnitine palmitoyltransferase 1b (muscle isoform) deficiency is lethal in the mouse. Mol Genet Metab 93(3):314\u2013322. https:\/\/doi.org\/10.1016\/j.ymgme.2007.10.006","journal-title":"Mol Genet Metab"},{"key":"1123_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00068","author":"QG Karwi","year":"2018","unstructured":"Karwi QG, Uddin GM, Ho KL, Lopaschuk GD (2018) Loss of metabolic flexibility in the failing heart. Front Cardiovasc Med. https:\/\/doi.org\/10.3389\/fcvm.2018.00068","journal-title":"Front Cardiovasc Med"},{"key":"1123_CR20","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1161\/circulationaha.105.551457","volume":"112","author":"L Lee","year":"2005","unstructured":"Lee L, Campbell R, Scheuermann-Freestone M, Taylor R, Gunaruwan P, Williams L, Ashrafian H, Horowitz J, Fraser AG, Clarke K, Frenneaux M (2005) Metabolic modulation with perhexiline in chronic heart failure: A randomized, controlled trial of short-term use of a novel treatment. Circulation 112:3280\u20133288. https:\/\/doi.org\/10.1161\/circulationaha.105.551457","journal-title":"Circulation"},{"key":"1123_CR21","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.yjmcc.2004.02.004","volume":"36","author":"B Lei","year":"2004","unstructured":"Lei B, Lionetti V, Young ME, Chandler MP, D\u2019Agostino C, Kang E, Altarejos M, Matsuo K, Hintze TH, Stanley WC, Recchia FA (2004) Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure. J Mol Cell Cardiol 36:567\u2013576. https:\/\/doi.org\/10.1016\/j.yjmcc.2004.02.004","journal-title":"J Mol Cell Cardiol"},{"key":"1123_CR22","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1006\/jmcc.2001.1378","volume":"33","author":"EJ Lesnefsky","year":"2001","unstructured":"Lesnefsky EJ, Moghaddas S, Tandler B, Kerner J, Hoppel CL (2001) Mitochondrial dysfunction in cardiac disease: Ischemia - reperfusion, aging, and heart failure. J Mol Cell Cardiol 33:1065\u20131089. https:\/\/doi.org\/10.1006\/jmcc.2001.1378","journal-title":"J Mol Cell Cardiol"},{"key":"1123_CR23","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.cardiores.2005.02.004","volume":"66","author":"V Lionetti","year":"2005","unstructured":"Lionetti V, Linke A, Chandler MP, Young ME, Penn MS, Gupte S, D\u2019Agostino C, Hintze TH, Stanley WC, Recchia FA (2005) Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure. Cardiovasc Res 66:454\u2013461. https:\/\/doi.org\/10.1016\/j.cardiores.2005.02.004","journal-title":"Cardiovasc Res"},{"key":"1123_CR24","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1161\/circresaha.107.150417","volume":"101","author":"GD Lopaschuk","year":"2007","unstructured":"Lopaschuk GD, Folmes CDL, Stanley WC (2007) Cardiac energy metabolism in obesity. Circ Res 101:335\u2013347. https:\/\/doi.org\/10.1161\/circresaha.107.150417","journal-title":"Circ Res"},{"key":"1123_CR25","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1161\/circresaha.121.318241","volume":"128","author":"GD Lopaschuk","year":"2021","unstructured":"Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED (2021) Cardiac energy metabolism in heart failure. Circ Res 128:1487\u20131513. https:\/\/doi.org\/10.1161\/circresaha.121.318241","journal-title":"Circ Res"},{"key":"1123_CR26","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2009","author":"GD Lopaschuk","year":"2010","unstructured":"Lopaschuk GD, Ussher JR, Folmes CDL, Jaswal JS, Stanley WC (2010) Myocardial fatty acid metabolism in health and disease. Physiol Rev. https:\/\/doi.org\/10.1152\/physrev.00015.2009","journal-title":"Physiol Rev"},{"key":"1123_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2016.157","volume":"49","author":"LD Ly","year":"2017","unstructured":"Ly LD, Xu S, Choi SK, Ha CM, Thoudam T, Cha SK, Wiederkehr A, Wollheim CB, Lee IK, Park KS (2017) Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes. Exp Mol Med 49:e291. https:\/\/doi.org\/10.1038\/emm.2016.157","journal-title":"Exp Mol Med"},{"key":"1123_CR28","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1093\/cvr\/cvaa159","volume":"117","author":"G Maroli","year":"2021","unstructured":"Maroli G, Braun T (2021) The long and winding road of cardiomyocyte maturation. Cardiovasc Res 117:712\u2013726. https:\/\/doi.org\/10.1093\/cvr\/cvaa159","journal-title":"Cardiovasc Res"},{"key":"1123_CR29","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1093\/eurheartj\/ehy249","volume":"39","author":"D Mosqueira","year":"2018","unstructured":"Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A, Denning C (2018) CRISPR\/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. Eur Heart J 39:3879\u20133892. https:\/\/doi.org\/10.1093\/eurheartj\/ehy249","journal-title":"Eur Heart J"},{"key":"1123_CR30","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1093\/cvr\/cvy274","volume":"115","author":"OJ Muller","year":"2019","unstructured":"Muller OJ, Heckmann MB, Ding L, Rapti K, Rangrez AY, Gerken T, Christiansen N, Rennefahrt UEE, Witt H, Gonzalez Maldonado S, Ternes P, Schwab DM, Ruf T, Hille S, Remes A, Jungmann A, Weis TM, Kreusser JS, Grone HJ, Backs J, Schatz P, Katus HA, Frey N (2019) Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure. Cardiovasc Res 115:1296\u20131305. https:\/\/doi.org\/10.1093\/cvr\/cvy274","journal-title":"Cardiovasc Res"},{"key":"1123_CR31","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.cardiores.2005.12.017","volume":"70","author":"OJ Muller","year":"2006","unstructured":"Muller OJ, Leuchs B, Pleger ST, Grimm D, Franz WM, Katus HA, Kleinschmidt JA (2006) Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors. Cardiovasc Res 70:70\u201378. https:\/\/doi.org\/10.1016\/j.cardiores.2005.12.017","journal-title":"Cardiovasc Res"},{"key":"1123_CR32","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jacc.2017.05.035","volume":"70","author":"T Munzel","year":"2017","unstructured":"Munzel T, Camici GG, Maack C, Bonetti NR, Fuster V, Kovacic JC (2017) Impact of oxidative stress on the heart and vasculature: part 2 of a 3-part series. J Am Coll Cardiol 70:212\u2013229. https:\/\/doi.org\/10.1016\/j.jacc.2017.05.035","journal-title":"J Am Coll Cardiol"},{"key":"1123_CR33","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1152\/ajpheart.00887.2007","volume":"293","author":"D Neglia","year":"2007","unstructured":"Neglia D, Caterina AD, Marraccini P, Natali A, Ciardetti M, Vecoli C, Gastaldelli A, Ciociaro D, Pellegrini P, Testa R, Menichetti L, L\u2019Abbate A, Stanley WC, Recchia FA (2007) Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy. American Journal of Physiology - Heart and Circulatory Physiology 293:3270\u20133278. https:\/\/doi.org\/10.1152\/ajpheart.00887.2007","journal-title":"American Journal of Physiology - Heart and Circulatory Physiology"},{"key":"1123_CR34","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1056\/nejmra063052","volume":"356","author":"S Neubauer","year":"2007","unstructured":"Neubauer S (2007) The Failing Heart \u2014 An Engine Out of Fuel. N Engl J Med 356:1140\u20131151. https:\/\/doi.org\/10.1056\/nejmra063052","journal-title":"N Engl J Med"},{"key":"1123_CR35","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1161\/01.Cir.0000023531.22727.C1","volume":"106","author":"JC Osorio","year":"2002","unstructured":"Osorio JC, Stanley WC, Linke A, Castellari M, Diep QN, Panchal AR, Hintze TH, Lopaschuk GD, Recchia FA (2002) Circulation 106:606\u2013612. https:\/\/doi.org\/10.1161\/01.Cir.0000023531.22727.C1","journal-title":"Circulation"},{"key":"1123_CR36","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1093\/cvr\/cvp004","volume":"82","author":"C Pellieux","year":"2009","unstructured":"Pellieux C, Montessuit C, Papageorgiou I, Lerch R (2009) Angiotensin II downregulates the fatty acid oxidation pathway in adult rat cardiomyocytes via release of tumour necrosis factor-\u03b1. Cardiovasc Res 82:341\u2013350. https:\/\/doi.org\/10.1093\/cvr\/cvp004","journal-title":"Cardiovasc Res"},{"key":"1123_CR37","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1161\/hc4901.100526","volume":"104","author":"P Razeghi","year":"2001","unstructured":"Razeghi P, Young ME, Alcorn JL, Moravec CS, Frazier OH, Taegtmeyer H (2001) Metabolic gene expression in fetal and failing human heart. Circulation 104:2923\u20132931. https:\/\/doi.org\/10.1161\/hc4901.100526","journal-title":"Circulation"},{"key":"1123_CR38","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1093\/cvr\/cvz161","volume":"115","author":"C Riehle","year":"2019","unstructured":"Riehle C, Bauersachs J (2019) Small animal models of heart failure. Cardiovasc Res 115:1838\u20131849. https:\/\/doi.org\/10.1093\/cvr\/cvz161","journal-title":"Cardiovasc Res"},{"key":"1123_CR39","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx017","author":"J Ritterhoff","year":"2017","unstructured":"Ritterhoff J, Tian R (2017) Metabolism in cardiomyopathy: every substrate matters. Cardiovasc Res. https:\/\/doi.org\/10.1093\/cvr\/cvx017","journal-title":"Cardiovasc Res"},{"key":"1123_CR40","doi-asserted-by":"publisher","first-page":"8277","DOI":"10.1073\/pnas.88.18.8277","volume":"88","author":"HA Rockman","year":"1991","unstructured":"Rockman HA, Ross RS, Harris AN, Knowlton KU, Steinhelper ME, Field LJ, Ross J, Chien KR (1991) Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc Natl Acad Sci USA 88:8277\u20138281. https:\/\/doi.org\/10.1073\/pnas.88.18.8277","journal-title":"Proc Natl Acad Sci USA"},{"key":"1123_CR41","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1096\/fasebj.6.6.1531968","volume":"6","author":"H Rupp","year":"1992","unstructured":"Rupp H, Elimban V, Dhalla NS (1992) Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J 6:2349\u20132353. https:\/\/doi.org\/10.1096\/fasebj.6.6.1531968","journal-title":"FASEB J"},{"key":"1123_CR42","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1042\/cs0990027","volume":"99","author":"S Schmidt-Schweda","year":"2000","unstructured":"Schmidt-Schweda S, Holubarsch C (2000) First clinical trial with etomoxir in patients with chronic congestive heart failure. Clin Sci (Lond) 99:27\u201335","journal-title":"Clin Sci (Lond)"},{"key":"1123_CR43","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1007\/s00395-009-0015-5","volume":"104","author":"M Schwarzer","year":"2009","unstructured":"Schwarzer M, Faerber G, Rueckauer T, Blum D, Pytel G, Mohr FW, Doenst T (2009) The metabolic modulators, Etomoxir and NVP-LAB121, fail to reverse pressure overload induced heart failure in vivo. Basic Res Cardiol 104:547\u2013557. https:\/\/doi.org\/10.1007\/s00395-009-0015-5","journal-title":"Basic Res Cardiol"},{"key":"1123_CR44","doi-asserted-by":"publisher","first-page":"E618","DOI":"10.1152\/ajpendo.00106.2011","volume":"301","author":"LK Steinbusch","year":"2011","unstructured":"Steinbusch LK, Luiken JJ, Vlasblom R, Chabowski A, Hoebers NT, Coumans WA, Vroegrijk IO, Voshol PJ, Ouwens DM, Glatz JF, Diamant M (2011) Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice. Am J Physiol Endocrinol Metab 301:E618-627. https:\/\/doi.org\/10.1152\/ajpendo.00106.2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1123_CR45","doi-asserted-by":"publisher","first-page":"3681","DOI":"10.1161\/01.Cir.96.10.3681","volume":"96","author":"M Turcani","year":"1997","unstructured":"Turcani M, Rupp H (1997) Etomoxir improves left ventricular performance of pressure-overloaded rat heart. Circulation 96:3681\u20133686. https:\/\/doi.org\/10.1161\/01.Cir.96.10.3681","journal-title":"Circulation"},{"key":"1123_CR46","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/sj.bjp.0702312","volume":"126","author":"M Turcani","year":"1999","unstructured":"Turcani M, Rupp H (1999) Modification of left ventricular hypertrophy by chronic etomoxir treatment. Br J Pharmacol 126:501\u2013507. https:\/\/doi.org\/10.1038\/sj.bjp.0702312","journal-title":"Br J Pharmacol"},{"key":"1123_CR47","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1161\/circulationaha.106.645184","volume":"114","author":"H Tuunanen","year":"2006","unstructured":"Tuunanen H, Engblom E, Naum A, N\u00e5gren K, Hesse B, Airaksinen KEJ, Nuutila P, Iozzo P, Ukkonen H, Opie LH, Knuuti J (2006) Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure. Circulation 114:2130\u20132137. https:\/\/doi.org\/10.1161\/circulationaha.106.645184","journal-title":"Circulation"},{"key":"1123_CR48","doi-asserted-by":"publisher","first-page":"26443","DOI":"10.1016\/s0021-9258(18)47214-6","volume":"269","author":"BC Weis","year":"1994","unstructured":"Weis BC, Cowan AT, Brown N, Foster DW, McGarry JD (1994) Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzyme. J Biol Chem 269:26443\u201326448. https:\/\/doi.org\/10.1016\/s0021-9258(18)47214-6","journal-title":"J Biol Chem"},{"key":"1123_CR49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/cvr\/cvu174","volume":"104","author":"S Werfel","year":"2014","unstructured":"Werfel S, Jungmann A, Lehmann L, Ksienzyk J, Bekeredjian R, Kaya Z, Leuchs B, Nordheim A, Backs J, Engelhardt S, Katus HA, M\u00fcller OJ (2014) Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase. Cardiovasc Res 104:15\u201323. https:\/\/doi.org\/10.1093\/cvr\/cvu174","journal-title":"Cardiovasc Res"},{"key":"1123_CR50","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1006\/jmcc.1999.0977","volume":"31","author":"PE Wolkowicz","year":"1999","unstructured":"Wolkowicz PE, Urthaler F, Forrest C, Shen H, Durand J, Wei CC, Oparil S, Dell\u2019Italia LJ (1999) 2-Tetradecylglycidic acid, an inhibitor of carnitine palmitoyltransferase-1, induces myocardial hypertrophy via the AT1 receptor. J Mol Cell Cardiol 31:1405\u20131412. https:\/\/doi.org\/10.1006\/jmcc.1999.0977","journal-title":"J Mol Cell Cardiol"},{"key":"1123_CR51","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1006\/jmcc.1999.0977","volume":"31","author":"PE Wolkowicz","year":"1999","unstructured":"Wolkowicz PE, Urthaler F, Forrest C, Shen H, Durand J, Wei CC, Oparil S, Dell\u2019Italia LJ (1999) 2-Tetradecylglycidic acid, an inhibitor of carnitine palmitoyltransferase-1, induces myocardial hypertrophy via the AT1 receptor. J Mol Cell Cardiol 31:1405\u20131412. https:\/\/doi.org\/10.1006\/jmcc.1999.0977","journal-title":"J Mol Cell Cardiol"},{"key":"1123_CR52","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41419-020-2374-7","volume":"11","author":"D Wu","year":"2020","unstructured":"Wu D, Jian C, Peng Q, Hou T, Wu K, Shang B, Zhao M, Wang Y, Zheng W, Ma Q, Li CY, Cheng H, Wang X, Zhao L (2020) Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure. Cell Death Dis 11:181\u2013181. https:\/\/doi.org\/10.1038\/s41419-020-2374-7","journal-title":"Cell Death Dis"},{"key":"1123_CR53","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.stemcr.2019.08.013","volume":"13","author":"X Yang","year":"2019","unstructured":"Yang X, Rodriguez ML, Leonard A, Sun L, Fischer KA, Wang Y, Ritterhoff J, Zhao L, Kolwicz SC Jr, Pabon L, Reinecke H, Sniadecki NJ, Tian R, Ruohola-Baker H, Xu H, Murry CE (2019) Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells. Stem Cell Reports 13:657\u2013668. https:\/\/doi.org\/10.1016\/j.stemcr.2019.08.013","journal-title":"Stem Cell Reports"},{"key":"1123_CR54","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/s0014-2999(00)00288-0","volume":"398","author":"T Yotsumoto","year":"2000","unstructured":"Yotsumoto T, Naitoh T, Kitahara M, Tsuruzoe N (2000) Effects of carnitine palmitoyltransferase I inhibitors on hepatic hypertrophy. Eur J Pharmacol 398:297\u2013302. https:\/\/doi.org\/10.1016\/s0014-2999(00)00288-0","journal-title":"Eur J Pharmacol"},{"key":"1123_CR55","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120849","author":"B Zhou","year":"2018","unstructured":"Zhou B, Tian R (2018) Mitochondrial dysfunction in pathophysiology of heart failure. J Clin Invest. https:\/\/doi.org\/10.1172\/JCI120849","journal-title":"J Clin Invest"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-025-01123-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-025-01123-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-025-01123-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:07:08Z","timestamp":1760368028000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-025-01123-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":55,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["1123"],"URL":"https:\/\/doi.org\/10.1007\/s00395-025-01123-y","relation":{},"ISSN":["1435-1803"],"issn-type":[{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,11]]},"assertion":[{"value":"20 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Animal experiments were executed with approval of the local authorities in Karlsruhe (approval of the Karlsruhe Regional Council 35-9185.81\/G-122\/12). Human sample collection was approved by the responsible ethics committee (permission numbers D462\/15 and D506\/22).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All the authors approved the final manuscript and agreed to publication in Basic Research in Cardiology.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}