{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:25:44Z","timestamp":1790717144339,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170386"],"award-info":[{"award-number":["82170386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100370"],"award-info":[{"award-number":["82100370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"DOI":"10.1007\/s00395-025-01145-6","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:56:52Z","timestamp":1762865812000},"page":"1155-1171","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mixed lineage kinase 3 contributes to myocardial ischemia\/reperfusion injury by regulating neutrophil activation"],"prefix":"10.1007","volume":"120","author":[{"given":"Zilong","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"1145_CR1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1093\/eurheartj\/ehu369","volume":"36","author":"A Abbate","year":"2015","unstructured":"Abbate A, Dinarello CA (2015) Anti-inflammatory therapies in acute coronary syndromes: is IL-1 blockade a solution? Eur Heart J 36:337\u2013339. https:\/\/doi.org\/10.1093\/eurheartj\/ehu369","journal-title":"Eur Heart J"},{"key":"1145_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.003","author":"I Ballesteros","year":"2020","unstructured":"Ballesteros I, Rubio-Ponce A, Genua M, Lusito E, Kwok I, Fern\u00e1ndez-Calvo G, Khoyratty TE, van Grinsven E, Gonz\u00e1lez-Hern\u00e1ndez S, Nicol\u00e1s-\u00c1vila J\u00c1, Vicanolo T, Maccataio A, Bengur\u00eda A, Li JL, Adrover JM, Aroca-Crevillen A, Quintana JA, Mart\u00edn-Salamanca S, Mayo F, Ascher S, Barbiera G, Soehnlein O, Gunzer M, Ginhoux F, S\u00e1nchez-Cabo F, Nistal-Vill\u00e1n E, Schulz C, Dopazo A, Reinhardt C, Udalova IA, Ng LG, Ostuni R, Hidalgo A (2020) Co-option of neutrophil fates by tissue environments. Cell. https:\/\/doi.org\/10.1016\/j.cell.2020.10.003","journal-title":"Cell"},{"key":"1145_CR3","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1182\/blood-2013-12-543850","volume":"125","author":"M Bartels","year":"2015","unstructured":"Bartels M, Govers AM, Fleskens V, Louren\u00e7o AR, Pals CE, Vervoort SJ, van Gent R, Brenkman AB, Bierings MB, Ackerman SJ, van Loosdregt J, Coffer PJ (2015) Acetylation of C\/EBP\u03b5 is a prerequisite for terminal neutrophil differentiation. Blood 125:1782\u20131792. https:\/\/doi.org\/10.1182\/blood-2013-12-543850","journal-title":"Blood"},{"key":"1145_CR4","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.immuni.2021.06.006","volume":"54","author":"GL Burn","year":"2021","unstructured":"Burn GL, Foti A, Marsman G, Patel DF, Zychlinsky A (2021) The neutrophil. Immunity 54:1377\u20131391. https:\/\/doi.org\/10.1016\/j.immuni.2021.06.006","journal-title":"Immunity"},{"key":"1145_CR5","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.149075","author":"TD Calamaras","year":"2021","unstructured":"Calamaras TD, Pande S, Baumgartner RA, Kim SK, McCarthy JC, Martin GL, Tam K, McLaughlin AL, Wang G-R, Aronovitz MJ, Lin W, Aguirre JI, Baca P, Liu P, Richards DA, Davis RJ, Karas RH, Jaffe IZ, Blanton RM (2021) MLK3 mediates impact of PKG1\u03b1 on cardiac function and controls blood pressure through separate mechanisms. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.149075","journal-title":"JCI Insight"},{"key":"1145_CR6","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1182\/blood-2012-01-401364","volume":"120","author":"G Chamilos","year":"2012","unstructured":"Chamilos G, Gregorio J, Meller S, Lande R, Kontoyiannis DP, Modlin RL, Gilliet M (2012) Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37. Blood 120:3699\u20133707. https:\/\/doi.org\/10.1182\/blood-2012-01-401364","journal-title":"Blood"},{"key":"1145_CR7","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1161\/circresaha.112.265868","volume":"110","author":"Y D\u00f6ring","year":"2012","unstructured":"D\u00f6ring Y, Drechsler M, Wantha S, Kemmerich K, Lievens D, Vijayan S, Gallo RL, Weber C, Soehnlein O (2012) Lack of neutrophil-derived CRAMP reduces atherosclerosis in mice. Circ Res 110:1052\u20131056. https:\/\/doi.org\/10.1161\/circresaha.112.265868","journal-title":"Circ Res"},{"key":"1145_CR8","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.immuni.2018.02.002","volume":"48","author":"M Evrard","year":"2018","unstructured":"Evrard M, Kwok IWH, Chong SZ, Teng KWW, Becht E, Chen J, Sieow JL, Penny HL, Ching GC, Devi S, Adrover JM, Li JLY, Liong KH, Tan L, Poon Z, Foo S, Chua JW, Su IH, Balabanian K, Bachelerie F, Biswas SK, Larbi A, Hwang WYK, Madan V, Koeffler HP, Wong SC, Newell EW, Hidalgo A, Ginhoux F, Ng LG (2018) Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions. Immunity 48:364-379.e368. https:\/\/doi.org\/10.1016\/j.immuni.2018.02.002","journal-title":"Immunity"},{"key":"1145_CR9","doi-asserted-by":"publisher","first-page":"792","DOI":"10.4049\/jimmunol.0900173","volume":"183","author":"L Franchi","year":"2009","unstructured":"Franchi L, Eigenbrod T, N\u00fa\u00f1ez G (2009) Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol 183:792\u2013796. https:\/\/doi.org\/10.4049\/jimmunol.0900173","journal-title":"J Immunol"},{"key":"1145_CR10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","volume":"11","author":"NG Frangogiannis","year":"2014","unstructured":"Frangogiannis NG (2014) The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol 11:255\u2013265. https:\/\/doi.org\/10.1038\/nrcardio.2014.28","journal-title":"Nat Rev Cardiol"},{"key":"1145_CR11","doi-asserted-by":"publisher","first-page":"E549","DOI":"10.1152\/ajpendo.00197.2013","volume":"305","author":"V Gadang","year":"2013","unstructured":"Gadang V, Kohli R, Myronovych A, Hui DY, Perez-Tilve D, Jaeschke A (2013) MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet. Am J Physiol Endocrinol Metab 305:E549\u2013E556. https:\/\/doi.org\/10.1152\/ajpendo.00197.2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1145_CR12","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1161\/ATVBAHA.114.303439","volume":"34","author":"V Gadang","year":"2014","unstructured":"Gadang V, Konaniah E, Hui DY, Jaeschke A (2014) Mixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 34:1429\u20131436. https:\/\/doi.org\/10.1161\/ATVBAHA.114.303439","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1145_CR13","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/nrm906","volume":"3","author":"KA Gallo","year":"2002","unstructured":"Gallo KA, Johnson GL (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol 3:663\u2013672","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1145_CR14","doi-asserted-by":"publisher","first-page":"8032","DOI":"10.1021\/jm401094t","volume":"56","author":"VS Goodfellow","year":"2013","unstructured":"Goodfellow VS, Loweth CJ, Ravula SB, Wiemann T, Nguyen T, Xu Y, Todd DE, Sheppard D, Pollack S, Polesskaya O, Marker DF, Dewhurst S, Gelbard HA (2013) Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem 56:8032\u20138048. https:\/\/doi.org\/10.1021\/jm401094t","journal-title":"J Med Chem"},{"key":"1145_CR15","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s13105-017-0561-5","volume":"73","author":"S He","year":"2016","unstructured":"He S, Liu S, Wu X, Xin M, Ding S, Xin D, Ouyang H, Zhang J (2016) Protective role of downregulated MLK3 in myocardial adaptation to chronic hypoxia. J Physiol Biochem 73:371\u2013380. https:\/\/doi.org\/10.1007\/s13105-017-0561-5","journal-title":"J Physiol Biochem"},{"key":"1145_CR16","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/S0140-6736(12)60916-7","volume":"381","author":"G Heusch","year":"2013","unstructured":"Heusch G (2013) Cardioprotection: chances and challenges of its translation to the clinic. Lancet 381:166\u2013175. https:\/\/doi.org\/10.1016\/S0140-6736(12)60916-7","journal-title":"Lancet"},{"key":"1145_CR17","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","volume":"17","author":"G Heusch","year":"2020","unstructured":"Heusch G (2020) Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17:773\u2013789. https:\/\/doi.org\/10.1038\/s41569-020-0403-y","journal-title":"Nat Rev Cardiol"},{"key":"1145_CR18","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.medj.2023.12.007","volume":"5","author":"G Heusch","year":"2024","unstructured":"Heusch G (2024) Myocardial ischemia\/reperfusion: translational pathophysiology of ischemic heart disease. Med 5:10\u201331. https:\/\/doi.org\/10.1016\/j.medj.2023.12.007","journal-title":"Med"},{"key":"1145_CR19","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/eurheartj\/ehw002","volume":"38","author":"M Horckmans","year":"2017","unstructured":"Horckmans M, Ring L, Duchene J, Santovito D, Schloss MJ, Drechsler M, Weber C, Soehnlein O, Steffens S (2017) Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype. Eur Heart J 38:187\u2013197. https:\/\/doi.org\/10.1093\/eurheartj\/ehw002","journal-title":"Eur Heart J"},{"key":"1145_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415205","volume":"12","author":"S Hu","year":"2025","unstructured":"Hu S, Zhang F, Wang J, Zhang J, Li C, Lyu Y, Wang Y, Huang R, Gao Y, Yang H, Qian J, Tang W, Cao J, Ge J (2025) MMP9(High) neutrophils are critical mediators of neutrophil extracellular traps formation and myocardial ischemia\/reperfusion injury. Adv Sci 12:e2415205. https:\/\/doi.org\/10.1002\/advs.202415205","journal-title":"Adv Sci"},{"key":"1145_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415205","author":"S Hu","year":"2025","unstructured":"Hu S, Zhang F, Wang J, Zhang J, Li C, Lyu Y, Wang Y, Huang R, Gao Y, Yang H, Qian J, Tang W, Cao J, Ge J (2025) MMP9High neutrophils are critical mediators of neutrophil extracellular traps formation and myocardial ischemia\/reperfusion injury. Adv Sci. https:\/\/doi.org\/10.1002\/advs.202415205","journal-title":"Adv Sci"},{"key":"1145_CR22","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1111\/bph.14155","volume":"175","author":"S Huang","year":"2018","unstructured":"Huang S, Frangogiannis NG (2018) Anti-inflammatory therapies in myocardial infarction: failures, hopes and challenges. Br J Pharmacol 175:1377\u20131400. https:\/\/doi.org\/10.1111\/bph.14155","journal-title":"Br J Pharmacol"},{"key":"1145_CR23","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1212\/01.wnl.0000277648.63931.c0","volume":"69","author":"P Investigators","year":"2007","unstructured":"Investigators P (2007) Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology 69:1480\u20131490. https:\/\/doi.org\/10.1212\/01.wnl.0000277648.63931.c0","journal-title":"Neurology"},{"key":"1145_CR24","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s00395-024-01057-x","volume":"119","author":"D K\u00f6hler","year":"2024","unstructured":"K\u00f6hler D, Leiss V, Beichert L, Killinger S, Grothe D, Kushwaha R, Schr\u00f6ter A, Roslan A, Eggstein C, Focken J, Granja T, Devanathan V, Schittek B, Lukowski R, Weigelin B, Rosenberger P, N\u00fcrnberg B, Beer-Hammer S (2024) Targeting G\u03b1i2 in neutrophils protects from myocardial ischemia reperfusion injury. Basic Res Cardiol 119:717\u2013732. https:\/\/doi.org\/10.1007\/s00395-024-01057-x","journal-title":"Basic Res Cardiol"},{"key":"1145_CR25","doi-asserted-by":"publisher","first-page":"4978","DOI":"10.1038\/ncomms5978","volume":"5","author":"D Kurotaki","year":"2014","unstructured":"Kurotaki D, Yamamoto M, Nishiyama A, Uno K, Ban T, Ichino M, Sasaki H, Matsunaga S, Yoshinari M, Ryo A, Nakazawa M, Ozato K, Tamura T (2014) IRF8 inhibits C\/EBP\u03b1 activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils. Nat Commun 5:4978. https:\/\/doi.org\/10.1038\/ncomms5978","journal-title":"Nat Commun"},{"key":"1145_CR26","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm0142","volume":"8","author":"A Lau","year":"2022","unstructured":"Lau A, Rahn JJ, Chappellaz M, Chung H, Benediktsson H, Bihan D, von M\u00e4ssenhausen A, Linkermann A, Jenne CN, Robbins SM, Senger DL, Lewis IA, Chun J, Muruve DA (2022) Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury. Sci Adv 8:eabm0142. https:\/\/doi.org\/10.1126\/sciadv.abm0142","journal-title":"Sci Adv"},{"key":"1145_CR27","doi-asserted-by":"publisher","first-page":"32408","DOI":"10.1074\/jbc.273.49.32408","volume":"273","author":"IW Leung","year":"1998","unstructured":"Leung IW, Lassam N (1998) Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3. J Biol Chem 273:32408\u201332415","journal-title":"J Biol Chem"},{"key":"1145_CR28","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1161\/01.CIR.80.6.1816","volume":"80","author":"MR Litt","year":"1989","unstructured":"Litt MR, Jeremy RW, Weisman HF, Winkelstein JA, Becker LC (1989) Neutrophil depletion limited to reperfusion reduces myocardial infarct size after 90 minutes of ischemia. Evidence for neutrophil-mediated reperfusion injury. Circulation 80:1816\u20131827","journal-title":"Circulation"},{"key":"1145_CR29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/cvr\/cvw024","volume":"110","author":"Y Ma","year":"2016","unstructured":"Ma Y, Yabluchanskiy A, Iyer RP, Cannon PL, Flynn ER, Jung M, Henry J, Cates CA, Deleon-Pennell KY, Lindsey ML (2016) Temporal neutrophil polarization following myocardial infarction. Cardiovasc Res 110:51\u201361. https:\/\/doi.org\/10.1093\/cvr\/cvw024","journal-title":"Cardiovasc Res"},{"key":"1145_CR30","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s002100000363","volume":"363","author":"MC Michel","year":"2001","unstructured":"Michel MC, Li Y, Heusch G (2001) Mitogen-activated protein kinases in the heart. Naunyn Schmiedebergs Arch Pharmacol 363:245\u2013266. https:\/\/doi.org\/10.1007\/s002100000363","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1145_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301348","volume":"10","author":"Q Mu","year":"2023","unstructured":"Mu Q, Yao K, Syeda MZ, Zhang M, Cheng Q, Zhang Y, Sun R, Lu Y, Zhang H, Luo Z, Huang H, Liu X, Luo C, Zhu X, Wu S, Cui L, Huang C, Chen X, Tang L (2023) Ligustrazine nanoparticle hitchhiking on neutrophils for enhanced therapy of cerebral ischemia-reperfusion injury. Adv Sci (Weinh) 10:e2301348. https:\/\/doi.org\/10.1002\/advs.202301348","journal-title":"Adv Sci (Weinh)"},{"key":"1145_CR32","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-018-03925-2","volume":"9","author":"J Pircher","year":"2018","unstructured":"Pircher J, Czermak T, Ehrlich A, Eberle C, Gaitzsch E, Margraf A, Grommes J, Saha P, Titova A, Ishikawa-Ankerhold H, Stark K, Petzold T, Stocker T, Weckbach LT, Novotny J, Sperandio M, Nieswandt B, Smith A, Mannell H, Walzog B, Horst D, Soehnlein O, Massberg S, Schulz C (2018) Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation. Nat Commun 9:1523. https:\/\/doi.org\/10.1038\/s41467-018-03925-2","journal-title":"Nat Commun"},{"key":"1145_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115938","volume":"169","author":"Q Ren","year":"2023","unstructured":"Ren Q, Liu Z, Wu L, Yin G, Xie X, Kong W, Zhou J, Liu S (2023) C\/EBP\u03b2: the structure, regulation, and its roles in inflammation-related diseases. Biomed Pharmacother = Biomedecine & pharmacotherapie 169:115938. https:\/\/doi.org\/10.1016\/j.biopha.2023.115938","journal-title":"Biomed Pharmacother = Biomedecine & pharmacotherapie"},{"key":"1145_CR34","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1161\/CIRCRESAHA.111.257535","volume":"110","author":"O Soehnlein","year":"2012","unstructured":"Soehnlein O (2012) Multiple roles for neutrophils in atherosclerosis. Circ Res 110:875\u2013888. https:\/\/doi.org\/10.1161\/CIRCRESAHA.111.257535","journal-title":"Circ Res"},{"key":"1145_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117476","volume":"180","author":"Y Tang","year":"2024","unstructured":"Tang Y, Jiao Y, An X, Tu Q, Jiang Q (2024) Neutrophil extracellular traps and cardiovascular disease: associations and potential therapeutic approaches. Biomed Pharmacother = Biomedecine & pharmacotherapie 180:117476. https:\/\/doi.org\/10.1016\/j.biopha.2024.117476","journal-title":"Biomed Pharmacother = Biomedecine & pharmacotherapie"},{"key":"1145_CR36","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.cardiores.2003.10.011","volume":"61","author":"J Vinten-Johansen","year":"2004","unstructured":"Vinten-Johansen J (2004) Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res 61:481\u2013497","journal-title":"Cardiovasc Res"},{"key":"1145_CR37","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/s41419-020-02777-3","volume":"11","author":"J Wang","year":"2020","unstructured":"Wang J, Deng B, Liu Q, Huang Y, Chen W, Li J, Zhou Z, Zhang L, Liang B, He J, Chen Z, Yan C, Yang Z, Xian S, Wang L (2020) Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload. Cell Death Dis 11:574. https:\/\/doi.org\/10.1038\/s41419-020-02777-3","journal-title":"Cell Death Dis"},{"key":"1145_CR38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.yjmcc.2019.12.011","volume":"139","author":"Y Wu","year":"2020","unstructured":"Wu Y, Zhang Y, Zhang J, Zhai T, Hu J, Luo H, Zhou H, Zhang Q, Zhou Z, Liu F (2020) Cathelicidin aggravates myocardial ischemia\/reperfusion injury via activating TLR4 signaling and P2X7R\/NLRP3 inflammasome. J Mol Cell Cardiol 139:75\u201386. https:\/\/doi.org\/10.1016\/j.yjmcc.2019.12.011","journal-title":"J Mol Cell Cardiol"},{"key":"1145_CR39","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.yjmcc.2023.08.006","volume":"183","author":"Z Xiao","year":"2023","unstructured":"Xiao Z, Wei X, Li M, Yang K, Chen R, Su Y, Yu Z, Liang Y, Ge J (2023) Myeloid-specific deletion of Capns1 attenuates myocardial infarction injury via restoring mitochondrial function and inhibiting inflammasome activation. J Mol Cell Cardiol 183:54\u201366. https:\/\/doi.org\/10.1016\/j.yjmcc.2023.08.006","journal-title":"J Mol Cell Cardiol"},{"key":"1145_CR40","doi-asserted-by":"publisher","first-page":"1558484","DOI":"10.3389\/fimmu.2025.1558484","volume":"16","author":"X Xuan","year":"2025","unstructured":"Xuan X, Fan J, Zhang J, Ren M, Feng L (2025) Immune in myocardial ischemia\/reperfusion injury: potential mechanisms and therapeutic strategies. Front Immunol 16:1558484. https:\/\/doi.org\/10.3389\/fimmu.2025.1558484","journal-title":"Front Immunol"},{"key":"1145_CR41","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1093\/eurheartj\/ehae205","volume":"45","author":"K Yang","year":"2024","unstructured":"Yang K, Gao R, Chen H, Hu J, Zhang P, Wei X, Shi J, Chen Y, Zhang L, Chen J, Lyu Y, Dong Z, Wei W, Hu K, Guo Y, Ge J, Sun A (2024) Myocardial reperfusion injury exacerbation due to ALDH2 deficiency is mediated by neutrophil extracellular traps and prevented by leukotriene C4 inhibition. Eur Heart J 45:1662\u20131680. https:\/\/doi.org\/10.1093\/eurheartj\/ehae205","journal-title":"Eur Heart J"},{"key":"1145_CR42","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1056\/NEJMra071667","volume":"357","author":"DM Yellon","year":"2007","unstructured":"Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357:1121\u20131135","journal-title":"N Engl J Med"},{"key":"1145_CR43","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1093\/jleuko\/qiae112","volume":"116","author":"G Yoon","year":"2024","unstructured":"Yoon G, Puentes R, Tran J, Multani A, Cobo ER (2024) The role of cathelicidins in neutrophil biology. J Leukoc Biol 116:689\u2013705. https:\/\/doi.org\/10.1093\/jleuko\/qiae112","journal-title":"J Leukoc Biol"},{"key":"1145_CR44","doi-asserted-by":"publisher","first-page":"1151926","DOI":"10.3389\/fimmu.2023.1151926","volume":"14","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Ul Ain Q, Schulz C, Pircher J (2023) Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation. Front Immunol 14:1151926. https:\/\/doi.org\/10.3389\/fimmu.2023.1151926","journal-title":"Front Immunol"},{"key":"1145_CR45","doi-asserted-by":"publisher","DOI":"10.3892\/br.2025.1991","volume":"23","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Wang Y, Li T, Wang H (2025) NETosis in myocardial ischemia-reperfusion injury: from mechanisms to therapies (Review). Biomed Rep 23:113. https:\/\/doi.org\/10.3892\/br.2025.1991","journal-title":"Biomed Rep"},{"key":"1145_CR46","doi-asserted-by":"publisher","first-page":"6672","DOI":"10.1038\/s41467-022-33631-z","volume":"13","author":"X Zhou","year":"2022","unstructured":"Zhou X, Zhang C, Wu X, Hu X, Zhang Y, Wang X, Zheng L, Gao P, Du J, Zheng W, Shang H, Hu K, Jiang Z, Nie Y, Hu S, Xiao RP, Zhu X, Xiong JW (2022) Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction. Nat Commun 13:6672. https:\/\/doi.org\/10.1038\/s41467-022-33631-z","journal-title":"Nat Commun"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-025-01145-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-025-01145-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-025-01145-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T09:45:01Z","timestamp":1764927901000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-025-01145-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,11]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1145"],"URL":"https:\/\/doi.org\/10.1007\/s00395-025-01145-6","relation":{},"ISSN":["1435-1803"],"issn-type":[{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,11]]},"assertion":[{"value":"29 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}