{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:08:13Z","timestamp":1779203293933,"version":"3.51.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010888","name":"Wuhan Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022020801010537"],"award-info":[{"award-number":["2022020801010537"]}],"id":[{"id":"10.13039\/501100010888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500417"],"award-info":[{"award-number":["82500417"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0526400"],"award-info":[{"award-number":["2024ZD0526400"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2025AFD342"],"award-info":[{"award-number":["2025AFD342"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"DOI":"10.1007\/s00395-026-01180-x","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:17:55Z","timestamp":1776745075000},"page":"459-479","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deubiquitinase USP43 exacerbates myocardial ischemia\u2013reperfusion injury by stabilizing ASK1 and activating the JNK\/P38 MAPK pathway"],"prefix":"10.1007","volume":"121","author":[{"given":"Wei","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guowei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingju","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-8644","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"1180_CR1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.tcm.2022.02.005","volume":"33","author":"M Algoet","year":"2023","unstructured":"Algoet M, Janssens S, Himmelreich U, Gsell W, Pusovnik M, Van den Eynde J, Oosterlinck W (2023) Myocardial ischemia-reperfusion injury and the influence of inflammation. Trends Cardiovasc Med 33:357\u2013366. https:\/\/doi.org\/10.1016\/j.tcm.2022.02.005","journal-title":"Trends Cardiovasc Med"},{"key":"1180_CR2","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1056\/NEJMra1606915","volume":"376","author":"JL Anderson","year":"2017","unstructured":"Anderson JL, Morrow DA (2017) Acute myocardial infarction. N Engl J Med 376:2053\u20132064. https:\/\/doi.org\/10.1056\/NEJMra1606915","journal-title":"N Engl J Med"},{"key":"1180_CR3","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.cardiores.2003.09.031","volume":"61","author":"SC Armstrong","year":"2004","unstructured":"Armstrong SC (2004) Protein kinase activation and myocardial ischemia\/reperfusion injury. Cardiovasc Res 61:427\u2013436. https:\/\/doi.org\/10.1016\/j.cardiores.2003.09.031","journal-title":"Cardiovasc Res"},{"key":"1180_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154603","volume":"109","author":"HY Chen","year":"2023","unstructured":"Chen HY, Zhou HF, Yang JH, Wan HT, He Y (2023) Guhong injection mitigates myocardial ischemia\/reperfusion injury by activating GST P to inhibit ASK1-JNK\/p38 pathway. Phytomedicine 109:154603. https:\/\/doi.org\/10.1016\/j.phymed.2022.154603","journal-title":"Phytomedicine"},{"key":"1180_CR5","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1042\/BJ20100323","volume":"429","author":"A Cuadrado","year":"2010","unstructured":"Cuadrado A, Nebreda AR (2010) Mechanisms and functions of p38 MAPK signalling. Biochem J 429:403\u2013417. https:\/\/doi.org\/10.1042\/BJ20100323","journal-title":"Biochem J"},{"key":"1180_CR6","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1126\/science.7569900","volume":"269","author":"M David","year":"1995","unstructured":"David M, Petricoin E 3rd, Benjamin C, Pine R, Weber MJ, Larner AC (1995) Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science 269:1721\u20131723. https:\/\/doi.org\/10.1126\/science.7569900","journal-title":"Science"},{"key":"1180_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-025-01475-x","volume":"15","author":"YH Dong","year":"2025","unstructured":"Dong YH, Hu S, Zhang R, Zhang TB, Feng Y, Sun WY, Zhang P, Chen JC, Zhao WY (2025) USP43 promotes cerebral ischemia-reperfusion injury via activation of TAK1. Cell Biosci 15:138. https:\/\/doi.org\/10.1186\/s13578-025-01475-x","journal-title":"Cell Biosci"},{"key":"1180_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0075-4","volume":"4","author":"MK Ghosh","year":"2019","unstructured":"Ghosh MK, Chakraborty D, Sarkar S, Bhowmik A, Basu M (2019) The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports. Signal Transduct Target Ther 4:42. https:\/\/doi.org\/10.1038\/s41392-019-0075-4","journal-title":"Signal Transduct Target Ther"},{"key":"1180_CR9","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.ijbiomac.2018.02.009","volume":"112","author":"WW Guo","year":"2018","unstructured":"Guo WW, Liu XJ, Li JJ, Shen YM, Zhou ZJ, Wang MM, Xie YY, Feng XM, Wang LY, Wu X (2018) Prdx1 alleviates cardiomyocyte apoptosis through ROS-activated MAPK pathway during myocardial ischemia\/reperfusion injury. Int J Biol Macromol 112:608\u2013615. https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.02.009","journal-title":"Int J Biol Macromol"},{"key":"1180_CR10","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1038\/s41422-018-0079-6","volume":"28","author":"L He","year":"2018","unstructured":"He L, Liu XH, Yang JG, Li WJ, Liu SM, Liu XJ, Yang ZR, Ren J, Wang Y, Shan L, Guan CJ, Pei F, Lei LD, Zhang Y, Yi X, Yang XH, Liang J, Liu R, Sun LY, Shang YF (2018) Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR\/PI3K\/AKT drives breast carcinogenesis. Cell Res 28:934\u2013951. https:\/\/doi.org\/10.1038\/s41422-018-0079-6","journal-title":"Cell Res"},{"key":"1180_CR11","doi-asserted-by":"publisher","first-page":"5742","DOI":"10.7150\/thno.56853","volume":"11","author":"SL Hu","year":"2021","unstructured":"Hu SL, Zhu L, Song YM, Zhao XR, Chen QP, Pan Y, Zhang JH, Bai Y, Zhang HW, Shao CL (2021) Radiation-induced abscopal reproductive effect is driven by TNF-\u03b1\/p38 MAPK\/Rac1 axis in Sertoli cells. Theranostics 11:5742\u20135758. https:\/\/doi.org\/10.7150\/thno.56853","journal-title":"Theranostics"},{"key":"1180_CR12","doi-asserted-by":"publisher","first-page":"4744","DOI":"10.7150\/ijbs.86767","volume":"19","author":"WT Jia","year":"2023","unstructured":"Jia WT, Liang SF, Lin WF, Li S, Yuan JY, Jin MM, Nie SC, Zhang YN, Zhai XF, Zhou LP, Ling CQ, Cheng BB, Ling C (2023) Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-\u03baB pathway. Int J Biol Sci 19:4744\u20134762. https:\/\/doi.org\/10.7150\/ijbs.86767","journal-title":"Int J Biol Sci"},{"key":"1180_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2019.108777","volume":"311","author":"A Khames","year":"2019","unstructured":"Khames A, Khalaf MM, Gad AM, Abd El-Raouf OM, Kandeil MA (2019) Nicorandil combats doxorubicin-induced nephrotoxicity via amendment of TLR4\/P38 MAPK\/NF\u03ba-B signaling pathway. Chem Biol Interact 311:108777. https:\/\/doi.org\/10.1016\/j.cbi.2019.108777","journal-title":"Chem Biol Interact"},{"key":"1180_CR14","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.3109\/13880209.2015.1014569","volume":"53","author":"S Kumphune","year":"2015","unstructured":"Kumphune S, Surinkaew S, Chattipakorn SC, Chattipakorn N (2015) Inhibition of p38 MAPK activation protects cardiac mitochondria from ischemia\/reperfusion injury. Pharm Biol 53:1831\u20131841. https:\/\/doi.org\/10.3109\/13880209.2015.1014569","journal-title":"Pharm Biol"},{"key":"1180_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06446-7","volume":"15","author":"MX Li","year":"2024","unstructured":"Li MX, Yu JT, Ju LG, Wang YJP, Jin W, Zhang RJ, Xiang W, Ji M, Du WZ, Wang G, Qian KY, Zhang Y, Xiao Y, Wang XH (2024) USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer. Cell Death Dis 15:44. https:\/\/doi.org\/10.1038\/s41419-024-06446-7","journal-title":"Cell Death Dis"},{"key":"1180_CR16","doi-asserted-by":"publisher","first-page":"2361862","DOI":"10.1080\/01443615.2024.2361862","volume":"44","author":"Q Li","year":"2024","unstructured":"Li Q, Li WH, Wang JH, Shi WJ, Wang TR (2024) Effect of ubiquitin-specific proteinase 43 on ovarian serous adenocarcinoma and its clinical significance. J Obstet Gynaecol 44:2361862. https:\/\/doi.org\/10.1080\/01443615.2024.2361862","journal-title":"J Obstet Gynaecol"},{"key":"1180_CR17","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1038\/cdd.2011.80","volume":"18","author":"CL Lin","year":"2011","unstructured":"Lin CL, Tseng HC, Chen RF, Chen WP, Su MJ, Fang KM, Wu ML (2011) Intracellular zinc release-activated ERK-dependent GSK-3\u03b2-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury. Cell Death Differ 18:1651\u20131663. https:\/\/doi.org\/10.1038\/cdd.2011.80","journal-title":"Cell Death Differ"},{"key":"1180_CR18","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1161\/CIRCRESAHA.121.318866","volume":"130","author":"JY Liu","year":"2022","unstructured":"Liu JY, Li W, Deng KQ, Tian S, Liu H, Shi HJ, Fang Q, Liu Z, Chen Z, Tian T, Gan SY, Hu FJ, Hu ML, Cheng X, Ji YX, Zhang P, She ZG, Zhang XJ, Chen SZ, Cai JJ, Li HL (2022) The E3 ligase TRIM16 is a key suppressor of pathological cardiac hypertrophy. Circ Res 130:1586\u20131600. https:\/\/doi.org\/10.1161\/CIRCRESAHA.121.318866","journal-title":"Circ Res"},{"key":"1180_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2023.104565","volume":"149","author":"Y Liu","year":"2023","unstructured":"Liu Y, Li L, Wang Z, Zhang J, Zhou Z (2023) Myocardial ischemia-reperfusion injury; molecular mechanisms and prevention. Microvasc Res 149:104565. https:\/\/doi.org\/10.1016\/j.mvr.2023.104565","journal-title":"Microvasc Res"},{"key":"1180_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1533352","volume":"15","author":"YT Ma","year":"2025","unstructured":"Ma YT, Li C, Shen Y, You WH, Han MX, Mu YF, Han FJ (2025) Mechanisms of the JNK\/p38 MAPK signaling pathway in drug resistance in ovarian cancer. Front Oncol 15:1533352. https:\/\/doi.org\/10.3389\/fonc.2025.1533352","journal-title":"Front Oncol"},{"key":"1180_CR21","doi-asserted-by":"publisher","first-page":"184134","DOI":"10.1172\/JCI184134","volume":"135","author":"Y Mastoor","year":"2025","unstructured":"Mastoor Y, Murphy E, Roman, (2025) Mechanisms of postischemic cardiac death and protection following myocardial injury. J Clin Invest 135:184134. https:\/\/doi.org\/10.1172\/JCI184134","journal-title":"J Clin Invest"},{"key":"1180_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/eurheartj\/ehad486","volume":"45","author":"MA Matter","year":"2024","unstructured":"Matter MA, Paneni F, Libby P, Frantz S, St\u00e4hli BE, Templin C, Mengozzi A, Wang YJ, K\u00fcndig TM, R\u00e4ber L, Ruschitzka F, Matter CM (2024) Inflammation in acute myocardial infarction: the good, the bad and the ugly. Eur Heart J 45:89\u2013103. https:\/\/doi.org\/10.1093\/eurheartj\/ehad486","journal-title":"Eur Heart J"},{"key":"1180_CR23","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s002100000363","volume":"363","author":"MC Michel","year":"2001","unstructured":"Michel MC, Li Y, Heusch G (2001) Mitogen-activated protein kinases in the heart. Naunyn Schmiedebergs Arch Pharmacol 363:245\u2013266. https:\/\/doi.org\/10.1007\/s002100000363","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1180_CR24","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1038\/s41423-020-0362-6","volume":"18","author":"F Mulas","year":"2021","unstructured":"Mulas F, Wang X, Song SS, Nishanth G, Yi WJ, Brunn A, Larsen PK, Isermann B, Kalinke U, Barragan A, Naumann M, Deckert M, Schl\u00fcter D (2021) The deubiquitinase OTUB1 augments NF-\u03baB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13. Cell Mol Immunol 18:1512\u20131527. https:\/\/doi.org\/10.1038\/s41423-020-0362-6","journal-title":"Cell Mol Immunol"},{"key":"1180_CR25","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1038\/s44318-024-00166-6","volume":"43","author":"T Pauzaite","year":"2024","unstructured":"Pauzaite T, Wit N, Seear RV, Nathan JA (2024) Deubiquitinating enzyme mutagenesis screens identify a USP43-dependent HIF-1 transcriptional response. EMBO J 43:3677\u20133709. https:\/\/doi.org\/10.1038\/s44318-024-00166-6","journal-title":"EMBO J"},{"key":"1180_CR26","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s10495-023-01873-x","volume":"29","author":"LP Pei","year":"2024","unstructured":"Pei LP, Zhao F, Zhang Y (2024) USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt\/\u03b2-catenin signaling pathway. Apoptosis 29:210\u2013228. https:\/\/doi.org\/10.1007\/s10495-023-01873-x","journal-title":"Apoptosis"},{"key":"1180_CR27","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.jhep.2018.06.014","volume":"69","author":"JJ Qin","year":"2018","unstructured":"Qin JJ, Mao WZ, Wang XZ, Sun P, Cheng DQ, Tian S, Zhu XY, Yang L, Huang Z, Li HL (2018) Caspase recruitment domain 6 protects against hepatic ischemia\/reperfusion injury by suppressing ASK1. J Hepatol 69:1110\u20131122. https:\/\/doi.org\/10.1016\/j.jhep.2018.06.014","journal-title":"J Hepatol"},{"key":"1180_CR28","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1152\/physrev.00054.2009","volume":"90","author":"BA Rose","year":"2010","unstructured":"Rose BA, Force T, Wang YB (2010) Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev 90:1507\u20131546. https:\/\/doi.org\/10.1152\/physrev.00054.2009","journal-title":"Physiol Rev"},{"key":"1180_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06805-4","volume":"15","author":"HJ Shi","year":"2024","unstructured":"Shi HJ, Yu YJ, Li DJ, Zhu K, Cheng X, Ma TF, Tao ZQ, Hong Y, Liu Z, Zhou SY, Zhang JQ, Chen Y, Zhang XJ, Zhang P, Li HL (2024) TNIP3 protects against pathological cardiac hypertrophy by stabilizing STAT1. Cell Death Dis 15:450. https:\/\/doi.org\/10.1038\/s41419-024-06805-4","journal-title":"Cell Death Dis"},{"key":"1180_CR30","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3109\/10799893.2015.1030412","volume":"35","author":"Y Sun","year":"2015","unstructured":"Sun Y, Liu WZ, Liu T, Feng X, Yang N, Zhou HF (2015) Signaling pathway of MAPK\/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J Recept Signal Transduct Res 35:600\u2013604. https:\/\/doi.org\/10.3109\/10799893.2015.1030412","journal-title":"J Recept Signal Transduct Res"},{"key":"1180_CR31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1247\/csf.28.23","volume":"28","author":"K Takeda","year":"2003","unstructured":"Takeda K, Matsuzawa A, Nishitoh H, Ichijo H (2003) Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct Funct 28:23\u201329. https:\/\/doi.org\/10.1247\/csf.28.23","journal-title":"Cell Struct Funct"},{"key":"1180_CR32","doi-asserted-by":"publisher","first-page":"F373","DOI":"10.1152\/ajprenal.00208.2016","volume":"311","author":"GH Tesch","year":"2016","unstructured":"Tesch GH, Ma FY, Nikolic-Paterson DJ (2016) ASK1: a new therapeutic target for kidney disease. Am J Physiol Renal Physiol 311:F373\u2013F381. https:\/\/doi.org\/10.1152\/ajprenal.00208.2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"1180_CR33","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.002360","volume":"1","author":"S Toldo","year":"2012","unstructured":"Toldo S, Breckenridge DG, Mezzaroma E, Van Tassell BW, Shryock J, Kannan H, Phan D, Budas G, Farkas D, Lesnefsky E, Voelkel N, Abbate A (2012) Inhibition of apoptosis signal-regulating kinase 1 reduces myocardial ischemia-reperfusion injury in the mouse. J Am Heart Assoc 1:e002360. https:\/\/doi.org\/10.1161\/JAHA.112.002360","journal-title":"J Am Heart Assoc"},{"key":"1180_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123670","volume":"326","author":"D Wang","year":"2025","unstructured":"Wang D, Xu AX, Su HT, Zhang YP, Jiang LL, Wang YG, Liang GL, Zhang Y (2025) Sustained release of dual p38 inhibitors via supramolecular hydrogels to enhance cardiac repair after MI\/R injury. Biomaterials 326:123670. https:\/\/doi.org\/10.1016\/j.biomaterials.2025.123670","journal-title":"Biomaterials"},{"key":"1180_CR35","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1161\/CIRCULATIONAHA.125.073937","volume":"152","author":"J Wang","year":"2025","unstructured":"Wang J, Yang Bennett DS, Echard EJ, Chen B, Ciampa G, Zhao W, Shi Q, Yoon JY, Weiss RM, Grueter CE, Hall DD, London B, Song LS (2025) Junctophilin-2 regulates store-operated calcium entry to drive cardiac fibroblast activation, fibrotic repair, and angiogenesis after myocardial infarction. Circulation 152:699\u2013716. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.125.073937","journal-title":"Circulation"},{"key":"1180_CR36","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2022.5200","volume":"50","author":"Y Wang","year":"2022","unstructured":"Wang Y, Gao H, Cao XH, Li Z, Kuang Y, Ji Y, Li Y (2022) Role of GADD45A in myocardial ischemia\/reperfusion through mediation of the JNK\/p38 MAPK and STAT3\/VEGF pathways. Int J Mol Med 50:144. https:\/\/doi.org\/10.3892\/ijmm.2022.5200","journal-title":"Int J Mol Med"},{"key":"1180_CR37","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1161\/CIRCULATIONAHA.106.679589","volume":"116","author":"YB Wang","year":"2007","unstructured":"Wang YB (2007) Mitogen-activated protein kinases in heart development and diseases. Circulation 116:1413\u20131423. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.679589","journal-title":"Circulation"},{"key":"1180_CR38","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1016\/j.jacc.2024.02.056","volume":"83","author":"FGP Welt","year":"2024","unstructured":"Welt FGP, Batchelor W, Spears JR, Penna C, Pagliaro P, Ibanez B, Drakos SG, Dangas G, Kapur NK (2024) Reperfusion injury in patients with acute myocardial infarction: JACC scientific statement. J Am Coll Cardiol 83:2196\u20132213. https:\/\/doi.org\/10.1016\/j.jacc.2024.02.056","journal-title":"J Am Coll Cardiol"},{"key":"1180_CR39","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.tem.2023.10.010","volume":"35","author":"Q Xiang","year":"2024","unstructured":"Xiang Q, Yi X, Zhu XH, Wei X, Jiang DS (2024) Regulated cell death in myocardial ischemia-reperfusion injury. Trends Endocrinol Metab 35:219\u2013234. https:\/\/doi.org\/10.1016\/j.tem.2023.10.010","journal-title":"Trends Endocrinol Metab"},{"key":"1180_CR40","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012575","volume":"8","author":"WP Xu","year":"2019","unstructured":"Xu WP, Zhang L, Zhang Y, Zhang K, Wu YB, Jin DQ (2019) TRAF1 exacerbates myocardial ischemia reperfusion injury via ASK1-JNK\/p38 signaling. J Am Heart Assoc 8:e012575. https:\/\/doi.org\/10.1161\/JAHA.119.012575","journal-title":"J Am Heart Assoc"},{"key":"1180_CR41","doi-asserted-by":"publisher","first-page":"404","DOI":"10.7150\/jca.48056","volume":"12","author":"DX Ye","year":"2021","unstructured":"Ye DX, Wang SS, Huang Y, Wang XJ, Chi P (2021) USP43 directly regulates ZEB1 protein, mediating proliferation and metastasis of colorectal cancer. J Cancer 12:404\u2013416. https:\/\/doi.org\/10.7150\/jca.48056","journal-title":"J Cancer"},{"key":"1180_CR42","doi-asserted-by":"publisher","first-page":"6846","DOI":"10.1111\/jcmm.15340","volume":"24","author":"JJ Zeng","year":"2020","unstructured":"Zeng JJ, Jin QK, Ruan YX, Sun CZ, Xu GY, Chu MP, Ji KT, Wu LP, Li L (2020) Inhibition of TGF\u03b2-activated protein kinase 1 ameliorates myocardial ischaemia\/reperfusion injury via endoplasmic reticulum stress suppression. J Cell Mol Med 24:6846\u20136859. https:\/\/doi.org\/10.1111\/jcmm.15340","journal-title":"J Cell Mol Med"},{"key":"1180_CR43","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/s41401-023-01057-y","volume":"44","author":"JJ Zeng","year":"2023","unstructured":"Zeng JJ, Shi HQ, Ren FF, Zhao XS, Chen QY, Wang DJ, Wu LP, Chu MP, Lai TF, Li L (2023) Notoginsenoside R1 protects against myocardial ischemia\/reperfusion injury in mice via suppressing TAK1-JNK\/p38 signaling. Acta Pharmacol Sin 44:1366\u20131379. https:\/\/doi.org\/10.1038\/s41401-023-01057-y","journal-title":"Acta Pharmacol Sin"},{"key":"1180_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155649","volume":"129","author":"S Zhang","year":"2024","unstructured":"Zhang S, Yan F, Luan F, Chai Y, Li N, Wang YW, Chen ZL, Xu DQ, Tang YP (2024) The pathological mechanisms and potential therapeutic drugs for myocardial ischemia reperfusion injury. Phytomedicine 129:155649. https:\/\/doi.org\/10.1016\/j.phymed.2024.155649","journal-title":"Phytomedicine"},{"key":"1180_CR45","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1016\/j.cmet.2021.08.014","volume":"33","author":"XJ Zhang","year":"2021","unstructured":"Zhang XJ, Liu XL, Hu ML, Zhao GJ, Sun DT, Cheng X, Xiang H, Huang YP, Tian RF, Shen LJ, Ma JP, Wang HP, Tian S, Gan SY, Xu HB, Liao RF, Zou TJ, Ji YX, Zhang P, Cai JJ, Wang ZV, Meng GN, Xu QB, Wang YB, Ma XL, Liu PP, Huang Z, Zhu LH, She ZG, Zhang X, Bai L, Yang HL, Lu ZB, Li HL (2021) Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species. Cell Metab 33:2059\u20132075. https:\/\/doi.org\/10.1016\/j.cmet.2021.08.014","journal-title":"Cell Metab"},{"key":"1180_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114217","volume":"149","author":"YH Zhang","year":"2025","unstructured":"Zhang YH, Liu YJ, Deng QC, Liu LF, Zhu WP (2025) USP43 drives cervical carcinoma progression through regulation of the Hippo\/TAZ pathway. Int Immunopharmacol 149:114217. https:\/\/doi.org\/10.1016\/j.intimp.2025.114217","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"1180_CR47","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1038\/s41418-025-01491-x","volume":"32","author":"XB Zhao","year":"2025","unstructured":"Zhao XB, Di QQ, Chen J, Ling J, Quan J, Zhao ZZZ, Li HR, Chen SY, Li XW, Guo XW, Wu H, Xiao Y, Chen WL (2025) The USP43\/RNF2 axis negatively regulates antiviral innate immunity by promoting TBK1 ubiquitination and degradation. Cell Death Differ 32(10):1806\u20131819. https:\/\/doi.org\/10.1038\/s41418-025-01491-x","journal-title":"Cell Death Differ"},{"key":"1180_CR48","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/4311388","volume":"2023","author":"ZQ Zhao","year":"2023","unstructured":"Zhao ZQ, Lin ZK, Guo X, Al-Danakh A, He H, Qin HN, Ma C, Zhang NN, Tan G (2023) Ubiquitin-specific protease 43 impacts pancreatic ductal adenocarcinoma prognosis by altering its proliferation and infiltration of surrounding immune cells. J Immunol Res 2023:4311388. https:\/\/doi.org\/10.1155\/2023\/4311388","journal-title":"J Immunol Res"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-026-01180-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-026-01180-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-026-01180-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:23:52Z","timestamp":1779200632000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-026-01180-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["1180"],"URL":"https:\/\/doi.org\/10.1007\/s00395-026-01180-x","relation":{},"ISSN":["1435-1803"],"issn-type":[{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"12 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"These authors declare no relevant financial or non-financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}