{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:14:56Z","timestamp":1788189296310,"version":"build-2803163510"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"European Union COST Actions EU-CARDIOPROTECTION","award":["CA16225"],"award-info":[{"award-number":["CA16225"]}]},{"name":"European Union COST Actions EU-CARDIOPROTECTION","award":["IG16225"],"award-info":[{"award-number":["IG16225"]}]},{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Basic Res Cardiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cardioprotection induced by repetitive ischemia\/reperfusion (I\/R) is not confined to the ischemic region but may extend to distant myocardial territories, a phenomenon termed intracardiac remote ischemic preconditioning (icRIPC). The present study aimed to evaluate the delayed effects of icRIPC on infarct size (IS), left ventricular (LV) function (LVF), and myocardial gene and protein expression. icRIPC was induced in 13 pigs by 3 cycles of 10\u00a0min ischemia\/10\u00a0min reperfusion of the left anterior descending coronary artery (LAD) (conditioning) territory, followed 24\u00a0h later by reperfused acute myocardial infarction (AMI) of the left circumflex artery (LCx) (infarcted) territory, induced by 90-min percutaneous balloon occlusion of the mid LCx followed by reperfusion (group icRIPC-AMI). Thirteen additional pigs underwent a sham icRIPC procedure followed by reperfused LCx AMI 24\u00a0h later and served as controls (group AMI). Five pigs from each group were euthanized at 3\u00a0days, and myocardial expression of nine selected genes was quantified by RT-qPCR in the distal LAD and LCx territories. Protein expression of the two significantly upregulated genes was assessed by Western blot. The remaining eight pigs in each group were followed for 1\u00a0month. At 3\u00a0days after reperfused AMI, superoxide dismutase-2 (SOD2) protein expression was increased in the infarcted LCx territory of the icRIPC-AMI group, whereas inducible nitric oxide synthase (iNOS\/NOS2) protein expression was increased in the distal LAD territory. At 1\u00a0month, IS was lower in the icRIPC-AMI than in the AMI group (8.4\u00b13.7% vs. 14.1\u00b11.8% of LV mass,\n                    <jats:italic>p<\/jats:italic>\n                    =0.003), whereas global LVF was marginally improved. However, segmental mean contraction velocity of the infarcted lateral wall was higher in the icRIPC-AMI than in the AMI group (14.8\u00b11.6 vs. 13.3\u00b10.9\u00a0mm\/s,\n                    <jats:italic>p<\/jats:italic>\n                    =0.026). These findings provide potentially mechanistic evidence for delayed icRIPC, characterized by reduced IS, improved regional myocardial function, and territory-specific changes in cardioprotective protein expression, and may represent an experimental correlate of the clinical phenomenon of pre-infarction angina.\n                  <\/jats:p>","DOI":"10.1007\/s00395-026-01208-2","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:25:12Z","timestamp":1788186312000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed intracardiac remote ischemic preconditioning reduces infarct size in remote myocardium of pigs"],"prefix":"10.1007","author":[{"given":"Denise","family":"Traxler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Lukovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Spannbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ena","family":"Hasimbegovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Kastner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Riesenhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Zlabinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Auer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Pavo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Heusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-2107","authenticated-orcid":false,"given":"Mariann","family":"Gy\u00f6ngy\u00f6si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"issue":"3","key":"1208_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0732-3","volume":"114","author":"G Amanakis","year":"2019","unstructured":"Amanakis G, Kleinbongard P, Heusch G, Skyschally A (2019) Attenuation of ST-segment elevation after ischemic conditioning maneuvers reflects cardioprotection online. Basic Res Cardiol 114(3):22. https:\/\/doi.org\/10.1007\/s00395-019-0732-3","journal-title":"Basic Res Cardiol"},{"issue":"6","key":"1208_CR2","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1136\/hrt.2006.114504","volume":"93","author":"G Andreka","year":"2007","unstructured":"Andreka G, Vertesaljai M, Szantho G, Font G, Piroth Z, Fontos G, Juhasz ED, Szekely L, Szelid Z, Turner MS, Ashrafian H, Frenneaux MP, Andreka P (2007) Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs. Heart 93(6):749\u2013752. https:\/\/doi.org\/10.1136\/hrt.2006.114504","journal-title":"Heart"},{"issue":"1","key":"1208_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1166-z","volume":"15","author":"T Baranyai","year":"2017","unstructured":"Baranyai T, Giricz Z, Varga ZV, Koncsos G, Lukovic D, Makkos A, S\u00e1rk\u00f6zy M, P\u00e1v\u00f3 N, Jakab A, Czimbalmos C, V\u00e1g\u00f3 H, Ruzsa Z, T\u00f3th L, Garamv\u00f6lgyi R, Merkely B, Schulz R, Gy\u00f6ngy\u00f6si M, Ferdinandy P (2017) In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvasculature. J Transl Med 15(1):67. https:\/\/doi.org\/10.1186\/s12967-017-1166-z","journal-title":"J Transl Med"},{"issue":"1","key":"1208_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-022-00947-2","volume":"117","author":"RM Bell","year":"2022","unstructured":"Bell RM, Basalay M, B\u00f8tker HE, Beikoghli Kalkhoran S, Carr RD, Cunningham J, Davidson SM, England TJ, Giesz S, Ghosh AK, Golforoush P, Gourine AV, Hausenloy DJ, Heusch G, Ibanez B, Kleinbongard P, Lecour S, Lukhna K, Ntsekhe M, Ovize M, Salama AD, Vilahur G, Walker JM, Yellon DM (2022) Remote ischaemic conditioning: defining critical criteria for success-report from the 11th hatter cardiovascular workshop. Basic Res Cardiol 117(1):39. https:\/\/doi.org\/10.1007\/s00395-022-00947-2","journal-title":"Basic Res Cardiol"},{"issue":"11","key":"1208_CR5","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1161\/01.res.87.11.972","volume":"87","author":"R Bolli","year":"2000","unstructured":"Bolli R (2000) The late phase of preconditioning. Circ Res 87(11):972\u2013983. https:\/\/doi.org\/10.1161\/01.res.87.11.972","journal-title":"Circ Res"},{"issue":"5","key":"1208_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00395-018-0696-8","volume":"113","author":"HE Botker","year":"2018","unstructured":"Botker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmino S, Garca-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuh\u00e4user M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schl\u00fcter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113(5):39. https:\/\/doi.org\/10.1007\/s00395-018-0696-8","journal-title":"Basic Res Cardiol"},{"issue":"9716","key":"1208_CR7","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S0140-6736(09)620","volume":"375","author":"HE B\u00f8tker","year":"2010","unstructured":"B\u00f8tker HE, Kharbanda R, Schmidt MR, B\u00f8ttcher M, Kaltoft AK, Terkelsen CJ, Munk K, Andersen NH, Hansen TM, Trautner S, Lassen JF, Christiansen EH, Krusell LR, Kristensen SD, Thuesen L, Nielsen SS, Rehling M, S\u00f8rensen HT, Redington AN, Nielsen TT (2010) Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet 375(9716):727\u2013734. https:\/\/doi.org\/10.1016\/S0140-6736(09)620","journal-title":"Lancet"},{"issue":"5","key":"1208_CR8","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1136\/heartjnl-2015-307855","volume":"102","author":"H Bulluck","year":"2016","unstructured":"Bulluck H, Yellon DM, Hausenloy DJ (2016) Reducing myocardial IS: challenges and future opportunities. Heart 102(5):341\u2013348. https:\/\/doi.org\/10.1136\/heartjnl-2015-307855","journal-title":"Heart"},{"issue":"4","key":"1208_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-012-0277-1","volume":"107","author":"ZP Cai","year":"2012","unstructured":"Cai ZP, Parajuli N, Zheng X, Becker L (2012) Remote ischemic preconditioning confers late protection against myocardial ischemia-reperfusion injury in mice by upregulating interleukin-10. Basic Res Cardiol 107(4):277. https:\/\/doi.org\/10.1007\/s00395-012-0277-1","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"1208_CR10","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1161\/hc0402.102975","volume":"105","author":"MD Cerqueira","year":"2002","unstructured":"Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS, American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the American heart association. Circulation 105(4):539\u2013542. https:\/\/doi.org\/10.1161\/hc0402.102975","journal-title":"Circulation"},{"issue":"5","key":"1208_CR11","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1093\/cvr\/cvy014","volume":"114","author":"H Chen","year":"2018","unstructured":"Chen H, Jing XY, Shen YJ, Wang TL, Ou C, Lu SF, Cai Y, Li Q, Chen X, Ding YJ, Yu XC, Zhu BM (2018) Stat5-dependent cardioprotection in late remote ischaemia preconditioning. Cardiovasc Res 114(5):679\u2013689. https:\/\/doi.org\/10.1093\/cvr\/cvy014","journal-title":"Cardiovasc Res"},{"issue":"12","key":"1208_CR12","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2312413","volume":"23","author":"L Chen","year":"2022","unstructured":"Chen L, Weng Y, Qing A, Li J, Yang P, Ye L, Zhu T (2022) Protective effect of remote ischemic preconditioning against myocardial ischemia-reperfusion injury in rats and mice: a systematic review and meta-analysis. Rev Cardiovasc Med 23(12):413. https:\/\/doi.org\/10.31083\/j.rcm2312413","journal-title":"Rev Cardiovasc Med"},{"issue":"8","key":"1208_CR13","doi-asserted-by":"publisher","first-page":"4151","DOI":"10.3390\/ijms22084151","volume":"22","author":"M Consegal","year":"2021","unstructured":"Consegal M, N\u00fa\u00f1ez N, Barba I, Benito B, Ruiz-Meana M, Inserte J, Ferreira-Gonz\u00e1lez I, Rodr\u00edguez-Sinovas A (2021) Citric acid cycle metabolites predict is in pigs submitted to transient coronary artery occlusion and treated with succinate dehydrogenase inhibitors or remote ischemic perconditioning. Int J Mol Sci 22(8):4151. https:\/\/doi.org\/10.3390\/ijms22084151","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1208_CR14","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.atherosclerosis.2012.09.008","volume":"226","author":"G De Luca","year":"2013","unstructured":"De Luca G, Parodi G, Sciagr\u00e0 R, Bellandi B, Comito V, Vergara R, Migliorini A, Valenti R, Antoniucci D (2013) Preinfarction angina does not affect IS in STEMI patients undergoing primary angioplasty. Atherosclerosis 226(1):153\u2013156. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2012.09.008","journal-title":"Atherosclerosis"},{"issue":"1","key":"1208_CR15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s00395-021-00896-2","volume":"116","author":"R Francis","year":"2021","unstructured":"Francis R, Chong J, Ramlall M, Bucciarelli-Ducci C, Clayton T, Dodd M, Engstr\u00f8m T, Evans R, Ferreira VM, Fontana M, Greenwood JP, Kharbanda RK, Kim WY, Kotecha T, L\u00f8nborg JT, Mathur A, M\u00f8ller UK, Moon J, Perkins A, Rakhit RD, Yellon DM, B\u00f8tker HE, Bulluck H, Hausenloy DJ (2021) Effect of remote ischaemic conditioning on IS and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2\/ERIC-PPCI CMR substudy. Basic Res Cardiol 116(1):59. https:\/\/doi.org\/10.1007\/s00395-021-00896-2","journal-title":"Basic Res Cardiol"},{"issue":"3","key":"1208_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0672-3","volume":"113","author":"A Gaspar","year":"2018","unstructured":"Gaspar A, Louren\u00e7o AP, Pereira M\u00c1, Azevedo P, Roncon-Albuquerque R Jr, Marques J, Leite-Moreira AF (2018) Randomized controlled trial of remote ischaemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI). Basic Res Cardiol 113(3):14. https:\/\/doi.org\/10.1007\/s00395-018-0672-3","journal-title":"Basic Res Cardiol"},{"key":"1208_CR17","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz192","author":"M Gy\u00f6ngy\u00f6si","year":"2020","unstructured":"Gy\u00f6ngy\u00f6si M, Lukovic D, Zlabinger K, Spannbauer A, Gugerell A, Pavo N, Traxler D, Pils D, Maurer G, Jakab A, Riesenhuber M, Pircher A, Winkler J, Bergler-Klein J (2020) Liposomal doxorubicin attenuates cardiotoxicity via induction of interferon-related DNA damage resistance. Cardiovasc Res. https:\/\/doi.org\/10.1093\/cvr\/cvz192","journal-title":"Cardiovasc Res"},{"issue":"10207","key":"1208_CR18","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/S0140-6736(19)32039-2","volume":"394","author":"DJ Hausenloy","year":"2019","unstructured":"Hausenloy DJ, Kharbanda RK, M\u00f8ller UK, Ramlall M, Aar\u00f8e J, Butler R, Bulluck H, Clayton T, Dana A, Dodd M, Engstrom T, Evans R, Lassen JF, Christensen EF, Garcia-Ruiz JM, Gorog DA, Hjort J, Houghton RF, Ibanez B, Knight R, Lippert FK, L\u00f8nborg JT, Maeng M, Milasinovic D, More R, Nicholas JM, Jensen LO, Perkins A, Radovanovic N, Rakhit RD, Ravkilde J, Ryding AD, Schmidt MR, Riddervold IS, S\u00f8rensen HT, Stankovic G, Varma M, Webb I, Terkelsen CJ, Greenwood JP, Yellon DM, B\u00f8tker HE, CONDI-2\/ERIC-PPCI Investigators (2019) Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction CONDI-2\/ERIC-PPCI: a single-blind andomized controlled trial. Lancet 394(10207):1415\u20131424. https:\/\/doi.org\/10.1016\/S0140-6736(19)32039-2","journal-title":"Lancet"},{"issue":"35","key":"1208_CR19","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1093\/eurheartj\/ehu286","volume":"35","author":"E Herrett","year":"2014","unstructured":"Herrett E, Bhaskaran K, Timmis A, Denaxas S, Hemingway H, Smeeth L (2014) Association between clinical presentations before myocardial infarction and coronary mortality: a prospective population-based study using linked electronic records. Eur Heart J 35(35):2363\u20132371. https:\/\/doi.org\/10.1093\/eurheartj\/ehu286","journal-title":"Eur Heart J"},{"issue":"24","key":"1208_CR22","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.1161\/01.cir.103.24.2876","volume":"103","author":"G Heusch","year":"2001","unstructured":"Heusch G (2001) Nitroglycerin and delayed preconditioning in humans: yet another new mechanism for an old drug? Circulation 103(24):2876\u20132878. https:\/\/doi.org\/10.1161\/01.cir.103.24.2876","journal-title":"Circulation"},{"issue":"6","key":"1208_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00395-019-0756-8","volume":"114","author":"G Heusch","year":"2019","unstructured":"Heusch G (2019) Coronary microvascular obstruction: the new frontier in cardioprotection. Basic Res Cardiol 114(6):45. https:\/\/doi.org\/10.1007\/s00395-019-0756-8","journal-title":"Basic Res Cardiol"},{"issue":"12","key":"1208_CR23","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","volume":"17","author":"G Heusch","year":"2020","unstructured":"Heusch G (2020) Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol 17(12):773\u2013789. https:\/\/doi.org\/10.1038\/s41569-020-0403-y","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"1208_CR21","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/s41569-021-00506-7","volume":"18","author":"G Heusch","year":"2021","unstructured":"Heusch G (2021) Myocardial stunning and hibernation revisited. Nat Rev Cardiol 18(7):522\u2013536. https:\/\/doi.org\/10.1038\/s41569-021-00506-7","journal-title":"Nat Rev Cardiol"},{"issue":"22","key":"1208_CR27","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1093\/eurheartj\/ehaf205","volume":"46","author":"G Heusch","year":"2025","unstructured":"Heusch G, Kleinbongard P (2025) Ischaemic conditioning: a renaissance with wider perspectives? Eur Heart J 46(22):2076\u20132078. https:\/\/doi.org\/10.1093\/eurheartj\/ehaf205","journal-title":"Eur Heart J"},{"issue":"6","key":"1208_CR29","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.yjmcc.2011.02.016","volume":"50","author":"G Heusch","year":"2011","unstructured":"Heusch G, Skyschally A, Schulz R (2011) The in-situ pig heart with regional ischemia\/reperfusion - ready for translation. J Mol Cell Cardiol 50(6):951\u2013963. https:\/\/doi.org\/10.1016\/j.yjmcc.2011.02.016","journal-title":"J Mol Cell Cardiol"},{"issue":"9932","key":"1208_CR28","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","volume":"383","author":"G Heusch","year":"2014","unstructured":"Heusch G, Libby P, Gersh B, Yellon D, B\u00f6hm M, Lopaschuk G, Opie L (2014) Cardiovascular remodelling in coronary artery disease and heart failure. Lancet 383(9932):1933\u20131943. https:\/\/doi.org\/10.1016\/S0140-6736(14)60107-0","journal-title":"Lancet"},{"issue":"2","key":"1208_CR26","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jacc.2014.10.031","volume":"65","author":"G Heusch","year":"2015","unstructured":"Heusch G, B\u00f8tker HE, Przyklenk K, Redington A, Yellon D (2015) Remote ischemic conditioning. J Am Coll Cardiol 65(2):177\u2013195. https:\/\/doi.org\/10.1016\/j.jacc.2014.10.031","journal-title":"J Am Coll Cardiol"},{"key":"1208_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102894","volume":"67","author":"G Heusch","year":"2023","unstructured":"Heusch G, Andreadou I, Bell R, Bertero E, Botker HE, Davidson SM, Downey J, Eaton P, Ferdinandy P, Gersh BJ, Giacca M, Hausenloy DJ, Ibanez B, Krieg T, Maack C, Schulz R, Sellke F, Shah AM, Thiele H, Yellon DM, Di Lisa F (2023) Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection. Redox Biol 67:102894. https:\/\/doi.org\/10.1016\/j.redox.2023.102894","journal-title":"Redox Biol"},{"issue":"19","key":"1208_CR25","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1093\/eurheartj\/ehad160","volume":"44","author":"G Heusch","year":"2023","unstructured":"Heusch G, B\u00f8tker HE, Ferdinandy P, Schulz R (2023) Primordial non-responsiveness: a neglected obstacle to cardioprotection. Eur Heart J 44(19):1687\u20131689. https:\/\/doi.org\/10.1093\/eurheartj\/ehad160","journal-title":"Eur Heart J"},{"issue":"3","key":"1208_CR30","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.jtcvs.2016.10.089","volume":"153","author":"LL Hocum Stone","year":"2017","unstructured":"Hocum Stone LL, Swingen C, Holley C, Wright C, Chappuis E, Ward HB, McFalls EO, Kelly RF (2017) Magnetic resonance imaging assessment of cardiac function in a swine model of hibernating myocardium 3 months following bypass surgery. J Thorac Cardiovasc Surg 153(3):582\u2013590. https:\/\/doi.org\/10.1016\/j.jtcvs.2016.10.089","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"1208_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00851-1","volume":"116","author":"I Ikonomidis","year":"2021","unstructured":"Ikonomidis I, Vlastos D, Andreadou I, Gazouli M, Efentakis P, Varoudi M, Makavos G, Kapelouzou A, Lekakis J, Parissis J, Katsanos S, Tsilivarakis D, Hausenloy DJ, Alexopoulos D, Cokkinos DV, B\u00f8tker HE, Iliodromitis EK (2021) Vascular conditioning prevents adverse left ventricular remodelling after acute myocardial infarction: a randomised remote conditioning study. Basic Res Cardiol 116(1):9. https:\/\/doi.org\/10.1007\/s00395-021-00851-1","journal-title":"Basic Res Cardiol"},{"issue":"5","key":"1208_CR32","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","volume":"98","author":"K Jomova","year":"2024","unstructured":"Jomova K, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M (2024) Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants. Arch Toxicol 98(5):1323\u20131367. https:\/\/doi.org\/10.1007\/s00204-024-03696-4","journal-title":"Arch Toxicol"},{"issue":"1","key":"1208_CR33","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12968-020-00683-3","volume":"22","author":"N Kawel-Boehm","year":"2020","unstructured":"Kawel-Boehm N, Hetzel SJ, Ambale-Venkatesh B, Captur G, Francois CJ, Jerosch-Herold M, Salerno M, Teague SD, Valsangiacomo-Buechel E, van der Geest RJ, Bluemke DA (2020) Reference ranges (\u201cnormal values\u201d) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update. J Cardiovasc Magn Reson 22(1):87. https:\/\/doi.org\/10.1186\/s12968-020-00683-3","journal-title":"J Cardiovasc Magn Reson"},{"issue":"6","key":"1208_CR34","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s00395-024-01083-9","volume":"119","author":"P Kleinbongard","year":"2024","unstructured":"Kleinbongard P, Arriola CG, Badimon L, Crisostomo V, Giricz Z, Gy\u00f6ngy\u00f6si M, Heusch G, Ibanez B, Kiss A, de Kleijn DPV, Podesser BK, Carracedo RR, Rodr\u00edguez-Sinovas A, Ruiz-Meana M, Sanchez Margallo FM, Vilahur G, Zamorano JL, Zaragoza C, Ferdinandy P, Hausenloy DJ (2024) The improving preclinical assessment of cardioprotective therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning. Basic Res Cardiol 119(6):893\u2013909. https:\/\/doi.org\/10.1007\/s00395-024-01083-9","journal-title":"Basic Res Cardiol"},{"issue":"6","key":"1208_CR35","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1161\/01.res.72.6.1293","volume":"72","author":"T Kuzuya","year":"1993","unstructured":"Kuzuya T, Hoshida S, Yamashita N, Fuji H, Oe H, Hori M, Kamada T, Tada M (1993) Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia. Circ Res 72(6):1293\u20131299. https:\/\/doi.org\/10.1161\/01.res.72.6.1293","journal-title":"Circ Res"},{"issue":"1","key":"1208_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00893-5","volume":"116","author":"S Lecour","year":"2021","unstructured":"Lecour S, Andreadou I, B\u00f8tker HE, Davidson SM, Heusch G, Ruiz-Meana M, Schulz R, Zuurbier CJ, Ferdinandy P, Hausenloy DJ (2021) IMproving preclinical assessment of cardioprotective therapies (IMPACT) criteria: guidelines of the EU-cardioprotection cost Action. Basic Res Cardiol 116(1):52. https:\/\/doi.org\/10.1007\/s00395-021-00893-5","journal-title":"Basic Res Cardiol"},{"issue":"6","key":"1208_CR37","doi-asserted-by":"publisher","first-page":"H1365","DOI":"10.1152\/ajpheart.00580.2022","volume":"323","author":"HR Lieder","year":"2022","unstructured":"Lieder HR, Skyschally A, Sturek M, Heusch G, Kleinbongard P (2022) Remote ischemic conditioning in Ossabaw minipigs induces the release of humoral cardioprotective triggers, but the myocardium does not respond with reduced IS. Am J Physiol Heart Circ Physiol 323(6):H1365\u2013H1375. https:\/\/doi.org\/10.1152\/ajpheart.00580.2022","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"1208_CR38","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s12013-014-9936-1","volume":"70","author":"Z Liu","year":"2014","unstructured":"Liu Z, Wang YL, Hua Q, Chu YY, Ji XM (2014) Late remote ischemic preconditioning provides benefit to patients undergoing elective percutaneous coronary intervention. Cell Biochem Biophys 70(1):437\u2013442. https:\/\/doi.org\/10.1007\/s12013-014-9936-1","journal-title":"Cell Biochem Biophys"},{"issue":"5","key":"1208_CR39","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/ejechocard\/jer296","volume":"13","author":"J L\u00f8nborg","year":"2012","unstructured":"L\u00f8nborg J, Kelb\u00e6k H, Vejlstrup N, B\u00f8tker HE, Kim WY, Holmvang L, J\u00f8rgensen E, Helqvist S, Saunam\u00e4ki K, Thuesen L, Krusell LR, Clemmensen P, Engstr\u00f8m T (2012) Influence of pre-infarction angina, collateral flow, and pre-procedural TIMI flow on myocardial salvage index by cardiac magnetic resonance in patients with ST-segment elevation myocardial infarction. Eur Heart J Cardiovasc Imaging 13(5):433\u2013443. https:\/\/doi.org\/10.1093\/ejechocard\/jer296","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"2","key":"1208_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020344","volume":"20","author":"D Lukovic","year":"2019","unstructured":"Lukovic D, Gugerell A, Zlabinger K, Winkler J, Pavo N, Baranyai T, Giricz Z, Varga ZV, Riesenhuber M, Spannbauer A, Traxler D, Jakab A, Garamv\u00f6lgyi R, Petnehazy \u00d6, Pils D, T\u00f3th L, Schulz R, Ferdinandy P, Gy\u00f6ngy\u00f6si M (2019) Transcriptional alterations by ischaemic postconditioning in a pig infarction model: impact on microvascular protection. Int J Mol Sci 20(2):344. https:\/\/doi.org\/10.3390\/ijms20020344","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1208_CR41","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1161\/01.cir.88.3.1264","volume":"88","author":"MS Marber","year":"1993","unstructured":"Marber MS, Latchman DS, Walker JM, Yellon DM (1993) Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 88(3):1264\u20131272. https:\/\/doi.org\/10.1161\/01.cir.88.3.1264","journal-title":"Circulation"},{"issue":"5","key":"1208_CR42","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1161\/01.cir.74.5.1124","volume":"74","author":"CE Murry","year":"1986","unstructured":"Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circ 74(5):1124\u20131136. https:\/\/doi.org\/10.1161\/01.cir.74.5.1124","journal-title":"Circ"},{"key":"1208_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-8-67","volume":"8","author":"AB Nygard","year":"2007","unstructured":"Nygard AB, J\u00f8rgensen CB, Cirera S, Fredholm M (2007) Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR. BMC Mol Biol 8:67. https:\/\/doi.org\/10.1186\/1471-2199-8-67","journal-title":"BMC Mol Biol"},{"issue":"40","key":"1208_CR44","doi-asserted-by":"publisher","first-page":"67227","DOI":"10.18632\/oncotarget.18438","volume":"8","author":"N Pavo","year":"2017","unstructured":"Pavo N, Lukovic D, Zlabinger K, Lorant D, Goliasch G, Winkler J, Pils D, Auer K, Ankersmit HJ, Giricz Z, S\u00e1rk\u00f6zy M, Jakab A, Garamv\u00f6lgyi R, Emmert MY, Hoerstrup SP, Hausenloy DJ, Ferdinandy P, Maurer G, Gy\u00f6ngy\u00f6si M (2017) Intrinsic remote conditioning of the myocardium as a comprehensive cardiac response to ischemia and reperfusion. Oncotarget 8(40):67227\u201367240. https:\/\/doi.org\/10.18632\/oncotarget.18438","journal-title":"Oncotarget"},{"key":"1208_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/srep43958","volume":"7","author":"N Pavo","year":"2017","unstructured":"Pavo N, Lukovic D, Zlabinger K, Zimba A, Lorant D, Goliasch G, Winkler J, Pils D, Auer K, Ankersmit HJ, Giricz Z, Baranyai T, S\u00e1rk\u00f6zy M, Jakab A, Garamv\u00f6lgyi R, Emmert MY, Hoerstrup SP, Hausenloy DJ, Ferdinandy P, Maurer G, Gy\u00f6ngy\u00f6si M (2017) Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling. Sci Rep 7:43958. https:\/\/doi.org\/10.1038\/srep43958","journal-title":"Sci Rep"},{"issue":"7","key":"1208_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410","volume":"18","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, W\u00fcrbel H (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol 18(7):e3000410. https:\/\/doi.org\/10.1371\/journal.pbio.3000410","journal-title":"PLoS Biol"},{"issue":"11","key":"1208_CR47","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013314","volume":"6","author":"K Pryds","year":"2016","unstructured":"Pryds K, B\u00f8ttcher M, Sloth AD, Munk K, Rahbek Schmidt M, B\u00f8tker HE (2016) Influence of preinfarction angina and coronary collateral blood flow on the efficacy of remote ischaemic conditioning in patients with ST segment elevation myocardial infarction: post hoc subgroup analysis of a randomised controlled trial. BMJ Open 6(11):e013314. https:\/\/doi.org\/10.1136\/bmjopen-2016-013314","journal-title":"BMJ Open"},{"issue":"3","key":"1208_CR48","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1161\/01.cir.87.3.893","volume":"87","author":"K Przyklenk","year":"1993","unstructured":"Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P (1993) Regional ischemic \u201cpreconditioning\u201d protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation 87(3):893\u2013899. https:\/\/doi.org\/10.1161\/01.cir.87.3.893","journal-title":"Circulation"},{"issue":"1","key":"1208_CR49","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1161\/CIRCINTERVENTIONS.112.973164","volume":"6","author":"R Reiter","year":"2013","unstructured":"Reiter R, Henry TD, Traverse JH (2013) Preinfarction angina reduces IS in ST-elevation myocardial infarction treated with percutaneous coronary intervention. Circ Cardiovasc Interv 6(1):52\u201358. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.112.973164","journal-title":"Circ Cardiovasc Interv"},{"issue":"3","key":"1208_CR50","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1093\/eurheartj\/ehv320","volume":"37","author":"M Roffi","year":"2016","unstructured":"Roffi M, Patrono C, Collet J-P, Mueller C, Valgimigli M, Andreotti F et al (2016) 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 37(3):267\u2013315","journal-title":"Eur Heart J"},{"key":"1208_CR51","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.ijcard.2015.03.328","volume":"187","author":"M Schmidt","year":"2015","unstructured":"Schmidt M, Horv\u00e1th-Puh\u00f3 E, Pedersen L, S\u00f8rensen HT, B\u00f8tker HE (2015) Time-dependent effect of preinfarction angina pectoris and intermittent claudication on mortality following myocardial infarction: a Danish nationwide cohort study. Int J Cardiol 187:462\u2013469. https:\/\/doi.org\/10.1016\/j.ijcard.2015.03.328","journal-title":"Int J Cardiol"},{"issue":"6","key":"1208_CR52","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.jcmg.2017.09.010","volume":"11","author":"BSN Selvadurai","year":"2018","unstructured":"Selvadurai BSN, Puntmann VO, Bluemke DA, Ferrari VA, Friedrich MG, Kramer CM, Kwong RY, Lombardi M, Prasad SK, Rademakers FE, Young AA, Kim RJ, Nagel E (2018) Definition of left ventricular segments for cardiac magnetic resonance imaging. JACC Cardiovasc Imaging 11(6):926\u2013928. https:\/\/doi.org\/10.1016\/j.jcmg.2017.09.010","journal-title":"JACC Cardiovasc Imaging"},{"issue":"1","key":"1208_CR53","doi-asserted-by":"publisher","first-page":"H159","DOI":"10.1152\/ajpheart.00152.2018","volume":"315","author":"A Skyschally","year":"2018","unstructured":"Skyschally A, Kleinbongard P, Lieder H, Gedik N, Stoian L, Amanakis G, Elbers E, Heusch G (2018) Humoral transfer and intramyocardial signal transduction of protection by remote ischemic perconditioning in pigs, rats, and mice. Am J Physiol Heart Circ Physiol 315(1):H159\u2013H172. https:\/\/doi.org\/10.1152\/ajpheart.00152.2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"9","key":"1208_CR54","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/j.jacc.2003.09.069","volume":"43","author":"SD Solomon","year":"2004","unstructured":"Solomon SD, Anavekar NS, Greaves S, Rouleau JL, Hennekens C, Pfeffer MA (2004) Angina pectoris prior to myocardial infarction protects against subsequent left ventricular remodeling. J Am Coll Cardiol 43(9):1511\u20131514. https:\/\/doi.org\/10.1016\/j.jacc.2003.09.069","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"1208_CR55","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1093\/eurheartj\/ehs215","volume":"33","author":"PG Steg","year":"2012","unstructured":"Steg PG, James SK, Atar D, Badano LP, Bl\u00f6mstrom-Lundqvist C, Borger MA, Di Mario C, Dickstein K, Ducrocq G, Fernandez-Aviles F, Gershlick AH, Giannuzzi P, Halvorsen S, Huber K, Juni P, Kastrati A, Knuuti J, Lenzen MJ, Mahaffey KW, Valgimigli M, Van\u2019t Hof A, Widimsky P, Zahger D (2012) Task Force on the management of ST-segment elevation acute myocardial infarction of the European society of cardiology (ESC); ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 33(20):2569\u20132619. https:\/\/doi.org\/10.1093\/eurheartj\/ehs215","journal-title":"Eur Heart J"},{"issue":"9892","key":"1208_CR56","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0140-6736(13)61450-6","volume":"382","author":"M Thielmann","year":"2013","unstructured":"Thielmann M, Kottenberg E, Kleinbongard P, Wendt D, Gedik N, Pasa S, Price V, Tsagakis K, Neuh\u00e4user M, Peters J, Jakob H, Heusch G (2013) Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial. Lancet 382(9892):597\u2013604. https:\/\/doi.org\/10.1016\/S0140-6736(13)61450-6","journal-title":"Lancet"},{"issue":"6","key":"1208_CR57","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1510\/icvts.2010.243600","volume":"11","author":"R Wagner","year":"2010","unstructured":"Wagner R, Piler P, Bedanova H, Adamek P, Grodecka L, Freiberger T (2010) Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial. Interact Cardiovasc Thorac Surg 11(6):758\u2013762. https:\/\/doi.org\/10.1510\/icvts.2010.243600","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"10","key":"1208_CR58","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1161\/CIRCRESAHA.110.236190","volume":"108","author":"M Wei","year":"2011","unstructured":"Wei M, Xin P, Li S, Tao J, Li Y, Li J, Liu M, Li J, Zhu W, Redington AN (2011) Repeated remote ischemic postconditioning protects against adverse left ventricular remodeling and improves survival in a rat model of myocardial infarction. Circ Res 108(10):1220\u20131225. https:\/\/doi.org\/10.1161\/CIRCRESAHA.110.236190","journal-title":"Circ Res"},{"issue":"18","key":"1208_CR59","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.omtm.2020.06.008","volume":"15","author":"J Winkler","year":"2020","unstructured":"Winkler J, Lukovic D, Mester-Tonczar J, Zlabinger K, Gugerell A, Pavo N, Jakab A, Szankai Z, Traxler D, M\u00fcller C, Spannbauer A, Riesenhuber M, Ha\u0161imbegovi\u0107 E, Dawkins J, Zimmermann M, Ankersmit HJ, Marb\u00e1n E, Gy\u00f6ngy\u00f6si M (2020) Quantitative hybrid cardiac [18F]FDG-PET-MRI images for assessment of cardiac repair by preconditioned cardiosphere-derived cells. Mol Ther Methods Clin Dev 15(18):354\u2013366. https:\/\/doi.org\/10.1016\/j.omtm.2020.06.008","journal-title":"Mol Ther Methods Clin Dev"},{"key":"1208_CR60","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1054142","volume":"9","author":"G Wood","year":"2023","unstructured":"Wood G, Johnsen PH, Pedersen ALD, Frederiksen CA, Poulsen SH, B\u00f8tker HE, Kim WY (2023) Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: the CONDI-2 echocardiographic sub-study. Front Cardiovasc Med 9:1054142. https:\/\/doi.org\/10.3389\/fcvm.2022.1054142","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"1208_CR61","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/0022-2828(95)90071-3","volume":"27","author":"DM Yellon","year":"1995","unstructured":"Yellon DM, Baxter GF (1995) A \u201csecond window of protection\u201d or delayed preconditioning phenomenon: future horizons for myocardial protection? J Mol Cell Cardiol 27(4):1023\u20131034. https:\/\/doi.org\/10.1016\/0022-2828(95)90071-3","journal-title":"J Mol Cell Cardiol"},{"issue":"38","key":"1208_CR62","doi-asserted-by":"publisher","DOI":"10.1590\/acb380423","volume":"15","author":"H Zhang","year":"2023","unstructured":"Zhang H, Li S, Jin Y (2023) Remote ischemic preconditioning-induced late cardioprotection: possible role of melatonin-mitoKATP-H2S signaling pathway. Acta Cir Bras 15(38):e380423. https:\/\/doi.org\/10.1590\/acb380423","journal-title":"Acta Cir Bras"}],"container-title":["Basic Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-026-01208-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00395-026-01208-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00395-026-01208-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:25:14Z","timestamp":1788186314000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00395-026-01208-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":62,"alternative-id":["1208"],"URL":"https:\/\/doi.org\/10.1007\/s00395-026-01208-2","relation":{},"ISSN":["1435-1803"],"issn-type":[{"value":"1435-1803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"24 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}