{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T20:32:37Z","timestamp":1778099557143,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Herz- Thorax- Gef\u00e4\u00dfchir"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Inzidenz und Letalit\u00e4t des akuten Herz-Kreislauf-Stillstands sind seit Jahrzehnten gleichbleibend hoch.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Fragestellung<\/jats:title>\n                <jats:p>Wie lassen sich die derzeit unbefriedigenden Ergebnisse nach einer Reanimation mit Blick auf das \u00dcberleben und die neurologischen, v.\u202fa. mit Blick auf die zerebralen Folgesch\u00e4den verbessern?<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Entwicklung eines therapeutischen Verfahrens zur Eind\u00e4mmung des Isch\u00e4mie\u2011\/Reperfusionsschadens im Tiermodell. Entwicklung eines f\u00fcr die Reanimation optimierten Ger\u00e4tesystems, mit dem sich eine kontrollierte Ganzk\u00f6rperreperfusion auch au\u00dferklinisch umsetzen l\u00e4sst.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Etablierung der CARL-Therapie in der Klinik und in der Behandlung von OHCA-Patienten. \u00dcbernahme der Therapie und des CARL-Systems in eine klinische Beobachtungsstudie. Erste Fallberichte, in denen Patienten einen OHCA auch nach Isch\u00e4miezeiten bis zu 2\u202fh ohne Sch\u00e4digung des Gehirns \u00fcberlebten.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerungen<\/jats:title>\n                <jats:p>Die CARL-Therapie eignet sich potenziell zur Behandlung reanimationspflichtiger Patienten mit einem auch \u00fcber l\u00e4ngere Zeit therapierefrakt\u00e4ren Herz-Kreislauf-Stillstand.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00398-022-00491-0","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T21:01:20Z","timestamp":1645218080000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["CARL\u00a0\u2013 kontrollierte Reperfusion des ganzen K\u00f6rpers","CARL\u2014Controlled reperfusion of the whole body"],"prefix":"10.1007","volume":"36","author":[{"given":"C","family":"Benk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Trummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-S.","family":"Pooth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Beyersdorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"491_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.resuscitation.2021.02.007","volume":"161","author":"J-T Gr\u00e4sner","year":"2021","unstructured":"Gr\u00e4sner\u00a0J\u2011T, Herlitz\u00a0J, Tjelmeland\u00a0IBM, Wnent\u00a0J, Masterson\u00a0S, Lilja\u00a0G et al (2021) European Resuscitation Council guidelines 2021: Epidemiology of cardiac arrest in Europe. 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C. Benk, G. Trummer, J.-S. Pooth und C.\u00a0Scherer sind in Teilzeit bei der Resuscitec GmbH besch\u00e4ftigt.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle nationalen Richtlinien zur Haltung und zum Umgang mit Labortieren wurden eingehalten, und die notwendigen Zustimmungen der zust\u00e4ndigen Beh\u00f6rden liegen vor. Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethikkommission, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patient\/-innen liegt eine Einverst\u00e4ndniserkl\u00e4rung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}