{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T20:27:50Z","timestamp":1754598470558},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Herzschr Elektrophys"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00399-018-0566-y","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T08:12:48Z","timestamp":1526371968000},"page":"171-177","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synkopen und Ionenkanalerkrankungen"],"prefix":"10.1007","volume":"29","author":[{"given":"Johanna","family":"M\u00fcller-Leisse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Zormpas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorben","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Duncker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Veltmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"566_CR1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.joa.2016.07.002","volume":"32","author":"C Antzelevitch","year":"2016","unstructured":"Antzelevitch C, Yan G\u2011X, Ackerman MJ et al (2016) J\u2011wave syndromes expert consensus conference report_ emerging concepts and gaps in knowledge. J\u00a0Arrhythm 32:315\u2013339","journal-title":"J Arrhythm"},{"key":"566_CR2","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1161\/CIRCULATIONAHA.115.015731","volume":"131","author":"GM Ferrari De","year":"2015","unstructured":"De Ferrari GM, Dusi V, Spazzolini C et\u00a0al (2015) Clinical management of catecholaminergic polymorphic ventricular tachycardia: the role of left cardiac sympathetic denervation. Circulation 131:2185\u20132193","journal-title":"Circulation"},{"key":"566_CR3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/eurheartj\/ehq381","volume":"32","author":"P Delise","year":"2011","unstructured":"Delise P, Allocca G, Marras E et\u00a0al (2011) Risk stratification in individuals with the Brugada type 1 ECG pattern without previous cardiac arrest: usefulness of a\u00a0combined clinical and electrophysiologic approach. Eur Heart\u00a0J 32:169\u2013176","journal-title":"Eur Heart J"},{"key":"566_CR4","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/S0735-1097(97)00020-X","volume":"29","author":"DJ Driscoll","year":"1997","unstructured":"Driscoll DJ, Jacobsen SJ, C\u2011BJ P, Wollan PC (1997) Syncope in children and adolescents. J\u00a0Am Coll Cardiol 29:1039\u20131045","journal-title":"J Am Coll Cardiol"},{"key":"566_CR5","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1161\/01.CIR.0000085071.28695.C4","volume":"108","author":"F Gaita","year":"2003","unstructured":"Gaita F (2003) Short QT syndrome: a familial cause of sudden death. Circulation 108:965\u2013970","journal-title":"Circulation"},{"key":"566_CR6","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jacc.2011.03.038","volume":"58","author":"C Giustetto","year":"2011","unstructured":"Giustetto C, Schimpf R, Mazzanti A et al (2011) Long-term follow-up of patients with short QT syndrome. J\u00a0Am Coll Cardiol 58:587\u2013595","journal-title":"J Am Coll Cardiol"},{"key":"566_CR7","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1161\/CIRCULATIONAHA.107.729368","volume":"117","author":"I Goldenberg","year":"2008","unstructured":"Goldenberg I, Moss AJ, Bradley J et al (2008) Long-QT syndrome after age 40. Circulation 117:2192\u20132201","journal-title":"Circulation"},{"key":"566_CR8","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1161\/CIRCULATIONAHA.108.829267","volume":"119","author":"M Hayashi","year":"2009","unstructured":"Hayashi M, Denjoy I, Extramiana F et\u00a0al (2009) Incidence and risk factors of arrhythmic events in catecholaminergic polymorphic ventricular tachycardia. Circulation 119:2426\u20132434","journal-title":"Circulation"},{"key":"566_CR9","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1016\/j.jacc.2017.08.029","volume":"70","author":"J Hernandez-Ojeda","year":"2017","unstructured":"Hernandez-Ojeda J, Arbelo E, Borras R et al (2017) Patients with brugada syndrome and implanted cardioverter-defibrillators. J\u00a0Am Coll Cardiol 70:1991\u20132002","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"566_CR10","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1001\/jama.296.10.1249","volume":"296","author":"JB Hobbs","year":"2006","unstructured":"Hobbs JB (2006) Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome. JAMA 296(10):1249\u20131254","journal-title":"JAMA"},{"key":"566_CR11","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1016\/j.jacc.2017.10.025","volume":"70","author":"A Mazzanti","year":"2017","unstructured":"Mazzanti A, Maragna R, Vacanti G et al (2017) Hydroquinidine prevents life-threatening arrhythmic events in patients with short\u00a0QT\u00a0syndrome. J\u00a0Am Coll Cardiol 70:3010\u20133015","journal-title":"J Am Coll Cardiol"},{"key":"566_CR12","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1161\/CIRCEP.113.000170","volume":"6","author":"CY Miyake","year":"2013","unstructured":"Miyake CY, Webster G, Czosek RJ et\u00a0al (2013) Efficacy of implantable cardioverter defibrillators in young patients with catecholaminergic polymorphic ventricular tachycardia: success depends on substrate. Circ Arrhythm Electrophysiol 6:579\u2013587","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"566_CR13","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1161\/01.CIR.101.6.616","volume":"101","author":"AJ Moss","year":"2000","unstructured":"Moss AJ, Zareba W, Hall WJ et al (2000) Effectiveness and limitations of blocker therapy in congenital long-QT syndrome. Circulation 101:616\u2013623","journal-title":"Circulation"},{"key":"566_CR14","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1253\/circj.67.511","volume":"67","author":"K Nakazawa","year":"2003","unstructured":"Nakazawa K, Sakurai T, Takagi A et\u00a0al (2003) Autonomic imbalance as a\u00a0property of symptomatic brugada syndrome. Circ\u00a0J 67:511\u2013514","journal-title":"Circ J"},{"issue":"2","key":"566_CR15","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.hrthm.2014.10.014","volume":"12","author":"LRAO Nordkamp","year":"2015","unstructured":"Nordkamp LRAO, Vink AS, Wilde AAM et\u00a0al (2015) Syncope in brugada syndrome_ prevalence, clinical significance, and clues from history taking to distinguish arrhythmic from nonarrhythmic causes. Heart Rhythm 12(2):367\u2013375. \n                    https:\/\/doi.org\/10.1016\/j.hrthm.2014.10.014","journal-title":"Heart Rhythm"},{"key":"566_CR16","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1001\/jama.292.11.1341","volume":"292","author":"SG Priori","year":"2004","unstructured":"Priori SG (2004) Association of long QT syndrome loci and cardiac events among patients treated with \u03b2\u2011blockers. JAMA 292:1341\u20131344","journal-title":"JAMA"},{"key":"566_CR17","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","volume":"36","author":"SG Priori","year":"2015","unstructured":"Priori SG, Blomstr\u00f6m-Lundqvist C, Mazzanti A et al (2015) 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart\u00a0J 36:2793\u20132867","journal-title":"Eur Heart J"},{"issue":"12","key":"566_CR18","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1016\/j.hrthm.2013.05.014","volume":"10","author":"SG Priori","year":"2013","unstructured":"Priori SG, Wilde AA, Horie M et\u00a0al (2013) HRS\/EHRA\/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromesexpert consensus statement on inherited primary arrhythmia syndromes. Heart Rhythm 10(12):1932\u20131963. \n                    https:\/\/doi.org\/10.1016\/j.hrthm.2013.05.014","journal-title":"Heart Rhythm"},{"key":"566_CR19","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1161\/CIRCULATIONAHA.109.887026","volume":"121","author":"V Probst","year":"2010","unstructured":"Probst V, Veltmann C, Eckardt L et al (2010) Long-term prognosis of patients diagnosed with brugada syndrome: results from the FINGER brugada syndrome registry. Circulation 121:635\u2013643","journal-title":"Circulation"},{"key":"566_CR20","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1161\/CIRCEP.114.002217","volume":"8","author":"TM Roston","year":"2015","unstructured":"Roston TM, Vinocur JM, Maginot KR et\u00a0al (2015) Catecholaminergic polymorphic ventricular tachycardia in children. Circ Arrhythm Electrophysiol 8:633\u2013642","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"8","key":"566_CR21","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.hrthm.2012.04.013","volume":"9","author":"F Sacher","year":"2012","unstructured":"Sacher F, Arsac F, Wilton SB et\u00a0al (2012) Syncope in brugada syndrome patients: prevalence, characteristics, and outcome. Heart Rhythm 9(8):1272\u20131279. \n                    https:\/\/doi.org\/10.1016\/j.hrthm.2012.04.013","journal-title":"Heart Rhythm"},{"key":"566_CR22","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1046\/j.1540-8167.2003.03278.x","volume":"14","author":"R Schimpf","year":"2003","unstructured":"Schimpf R, Wolpert C, Bianchi F et\u00a0al (2003) Congenital short QT syndrome and Implantable cardioverter defibrillator treatment:. Inherent risk for inappropriate shock delivery. J\u00a0Cardiovasc Electrophysiol 14:1273\u20131277","journal-title":"J Cardiovasc Electrophysiol"},{"key":"566_CR23","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1161\/CIRCULATIONAHA.111.062182","volume":"124","author":"PJ Schwartz","year":"2011","unstructured":"Schwartz PJ, Crotti L (2011) QTc behavior during exercise and genetic testing for the long-QT syndrome. Circulation 124:2181\u20132184","journal-title":"Circulation"},{"key":"566_CR24","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1093\/eurheartj\/ehx119","volume":"38","author":"J Sieira","year":"2017","unstructured":"Sieira J, Conte G, Ciconte G et\u00a0al (2017) A score model to predict risk of events in patients with brugada syndrome. Eur Heart\u00a0J 38:1756\u20131763","journal-title":"Eur Heart J"},{"key":"566_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/S1062-1458(02)01060-7","volume":"12","author":"ES Soteriades","year":"2003","unstructured":"Soteriades ES, Evans JC, Larson MG (2003) Incidence and prognosis of syncope. ACC Curr J Rev 12:74","journal-title":"ACC Curr. J. Rev."},{"issue":"5","key":"566_CR26","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.hrthm.2011.11.045","volume":"9","author":"Y Take","year":"2012","unstructured":"Take Y, Morita H, Toh N et al (2012) Identification of high-risk syncope related to ventricular fibrillation in patients with brugada syndrome. Heart Rhythm 9(5):752\u2013759. \n                    https:\/\/doi.org\/10.1016\/j.hrthm.2011.11.045","journal-title":"Heart Rhythm"},{"key":"566_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00392-009-0075-4","volume":"99","author":"C Veltmann","year":"2009","unstructured":"Veltmann C, Kuschyk J, Schimpf R et\u00a0al (2009) Prevention of inappropriate ICD shocks in patients with brugada syndrome. Clin Res Cardiol 99:37\u201344","journal-title":"Clin Res Cardiol"},{"key":"566_CR28","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.hrthm.2011.10.032","volume":"9","author":"C Veltmann","year":"2012","unstructured":"Veltmann C, Papavassiliu T, Konrad T et\u00a0al (2012) Insights into the location of type I ECG in patients with brugada syndrome: correlation of ECG and cardiovascular magnetic resonance imaging. Heart Rhythm 9:414\u2013421","journal-title":"Heart Rhythm"},{"key":"566_CR29","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1093\/europace\/eup189","volume":"11","author":"C Veltmann","year":"2009","unstructured":"Veltmann C, Wolpert C, Sacher F et\u00a0al (2009) Response to intravenous ajmaline: a\u00a0retrospective analysis of 677 ajmaline challenges. Europace 11:1345\u20131352","journal-title":"Europace"},{"key":"566_CR30","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.hrthm.2012.12.035","volume":"10","author":"H Watanabe","year":"2013","unstructured":"Watanabe H, van der Werf C, Roses-Noguer F et al (2013) Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 10:542\u2013547","journal-title":"Heart Rhythm"},{"key":"566_CR31","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1093\/europace\/eur277","volume":"14","author":"C Werf van der","year":"2012","unstructured":"van der Werf C, Zwinderman AH, Wilde AAM (2012) Therapeutic approach for patients with catecholaminergic polymorphic ventricular tachycardia: state of the art and future developments. Europace 14:175\u2013183","journal-title":"Europace"},{"key":"566_CR32","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1161\/CIRCULATIONAHA.116.021823","volume":"134","author":"AAM Wilde","year":"2016","unstructured":"Wilde AAM, Moss AJ, Kaufman ES et al (2016) Clinical aspects of type 3 long-QT syndromeclinical perspective. Circulation 134:872\u2013882","journal-title":"Circulation"},{"key":"566_CR33","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1056\/NEJM199810013391404","volume":"399","author":"W Zareba","year":"1998","unstructured":"Zareba W (1998) Influence of the genotype on the clinical course of the long-QT syndrome. N\u00a0Eng J Med 399:960\u2013965. \n                    https:\/\/doi.org\/10.1056\/NEJM199810013391404","journal-title":"N Eng J Med"}],"container-title":["Herzschrittmachertherapie + Elektrophysiologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00399-018-0566-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00399-018-0566-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00399-018-0566-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:10:03Z","timestamp":1557879003000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00399-018-0566-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["566"],"URL":"https:\/\/doi.org\/10.1007\/s00399-018-0566-y","relation":{},"ISSN":["0938-7412","1435-1544"],"issn-type":[{"value":"0938-7412","type":"print"},{"value":"1435-1544","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]},"assertion":[{"value":"6 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"J.\u00a0M\u00fcller-Leisse, C.\u00a0Zormpas, T.\u00a0K\u00f6nig, D.\u00a0Duncker und C.\u00a0Veltmann geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Dieser Beitrag beinhaltet keine von den Autoren durchgef\u00fchrten Studien an Menschen oder Tieren.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}]}}